locus-tag	class	description
I6J35_RS00005	COG3961	Belongs to the TPP enzyme family
I6J35_RS00015	COG1510	regulation of RNA biosynthetic process
I6J35_RS00020	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS00025	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6J35_RS00030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6J35_RS00030	COG4932	domain protein
I6J35_RS00030	COG3266	domain, Protein
I6J35_RS00030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6J35_RS00030	COG4932	domain protein
I6J35_RS00030	COG3266	domain, Protein
I6J35_RS00040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J35_RS00045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J35_RS00045	COG1263	PTS System
I6J35_RS00050	COG1737	Transcriptional regulator
I6J35_RS00090	COG0582	viral genome integration into host DNA
I6J35_RS00095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J35_RS00095	COG2111	Na H antiporter
I6J35_RS00100	COG2111	Na H antiporter
I6J35_RS00105	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J35_RS00115	COG1863	multisubunit Na H antiporter MnhE subunit
I6J35_RS00120	COG2212	antiporter activity
I6J35_RS00125	COG1320	monovalent cation:proton antiporter activity
I6J35_RS00140	COG1113	amino acid transport
I6J35_RS00150	COG1131	(ABC) transporter
I6J35_RS00160	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J35_RS00170	COG2376	Dihydroxyacetone kinase
I6J35_RS00175	COG1461	Dihydroxyacetone kinase
I6J35_RS00185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J35_RS00190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS00195	COG0438	transferase activity, transferring glycosyl groups
I6J35_RS00210	COG0438	transferase activity, transferring glycosyl groups
I6J35_RS00215	COG0463	Glycosyl transferase, family 2
I6J35_RS00215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS00220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J35_RS00225	COG0531	amino acid
I6J35_RS00250	COG0463	Glycosyl transferase, family 2
I6J35_RS00255	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J35_RS00265	COG1959	2 iron, 2 sulfur cluster binding
I6J35_RS00270	COG1131	(ABC) transporter
I6J35_RS00285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS00305	COG0318	PFAM AMP-dependent synthetase and ligase
I6J35_RS00320	COG2235	arginine
I6J35_RS00325	COG2235	arginine
I6J35_RS00335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J35_RS00340	COG1438	arginine binding
I6J35_RS00350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J35_RS00355	COG2022	thiamine diphosphate biosynthetic process
I6J35_RS00365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J35_RS00370	COG0352	thiamine-phosphate diphosphorylase activity
I6J35_RS00380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J35_RS00385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J35_RS00390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J35_RS00410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J35_RS00425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J35_RS00435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J35_RS00440	COG2807	transmembrane transport
I6J35_RS00445	COG5646	InterPro IPR014922
I6J35_RS00460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J35_RS00465	COG1984	allophanate hydrolase subunit 2
I6J35_RS00475	COG0439	Biotin carboxylase
I6J35_RS00480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J35_RS00485	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J35_RS00490	COG1070	Carbohydrate kinase
I6J35_RS00505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J35_RS00515	COG1695	Transcriptional regulator
I6J35_RS00560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J35_RS00575	COG3189	MarR family transcriptional regulator
I6J35_RS00585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J35_RS00600	COG0604	alcohol dehydrogenase
I6J35_RS00605	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6J35_RS00610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J35_RS00620	COG3001	Fructosamine kinase
I6J35_RS00635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J35_RS00650	COG3764	Sortase (surface protein transpeptidase)
I6J35_RS00655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J35_RS00690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J35_RS00710	COG1136	(ABC) transporter
I6J35_RS00715	COG0577	efflux transmembrane transporter activity
I6J35_RS00720	COG0583	DNA-binding transcription factor activity
I6J35_RS00735	COG0028	Belongs to the TPP enzyme family
I6J35_RS00745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J35_RS00755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J35_RS00760	COG1687	branched-chain amino acid
I6J35_RS00765	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6J35_RS00790	COG1760	l-serine dehydratase
I6J35_RS00795	COG1760	l-serine dehydratase
I6J35_RS00820	COG0778	Nitroreductase
I6J35_RS00830	COG1132	(ABC) transporter
I6J35_RS00835	COG1132	(ABC) transporter
I6J35_RS00845	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J35_RS00850	COG1846	Transcriptional regulator
I6J35_RS00855	COG0346	lactoylglutathione lyase activity
I6J35_RS00860	COG2211	Major facilitator Superfamily
I6J35_RS00865	COG2207	Transcriptional regulator
I6J35_RS00870	COG3250	beta-galactosidase activity
I6J35_RS00875	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J35_RS00880	COG1131	(ABC) transporter
I6J35_RS00890	COG0586	Pfam SNARE associated Golgi protein
I6J35_RS00895	COG2271	Major facilitator Superfamily
I6J35_RS00900	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J35_RS00905	COG3527	Alpha-acetolactate decarboxylase
I6J35_RS00915	COG4876	unkown
I6J35_RS00920	COG0523	cobalamin synthesis protein
I6J35_RS00925	COG2357	RelA SpoT domain protein
I6J35_RS00940	COG2808	Putative FMN-binding domain
I6J35_RS00945	COG1802	Transcriptional regulator
I6J35_RS00950	COG1070	Carbohydrate kinase
I6J35_RS00955	COG2610	gluconate transmembrane transporter activity
I6J35_RS00965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J35_RS00970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J35_RS00995	COG4619	ABC transporter
I6J35_RS01000	COG0390	transport system, permease component
I6J35_RS01005	COG2814	Major facilitator Superfamily
I6J35_RS01010	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J35_RS01015	COG0531	amino acid
I6J35_RS01020	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6J35_RS01030	COG1174	glycine betaine transport
I6J35_RS01040	COG1174	glycine betaine transport
I6J35_RS01050	COG1309	transcriptional regulator
I6J35_RS01065	COG1346	cytolysis
I6J35_RS01075	COG3279	Response regulator of the LytR AlgR family
I6J35_RS01080	COG3275	phosphorelay sensor kinase activity
I6J35_RS01100	COG0531	amino acid
I6J35_RS01105	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6J35_RS01110	COG1113	amino acid transport
I6J35_RS01120	COG2814	Major facilitator Superfamily
I6J35_RS01130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J35_RS01135	COG0741	lytic transglycosylase activity
I6J35_RS01140	COG0588	phosphoglycerate mutase activity
I6J35_RS01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J35_RS01155	COG0765	amino acid transport
I6J35_RS01160	COG1126	abc transporter atp-binding protein
I6J35_RS01200	COG2116	formate transmembrane transporter activity
I6J35_RS01215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J35_RS01220	COG2146	nitrite reductase [NAD(P)H] activity
I6J35_RS01225	COG1648	precorrin-2 dehydrogenase activity
I6J35_RS01225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J35_RS01230	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J35_RS01235	COG1140	nitrate reductase beta subunit
I6J35_RS01245	COG2181	nitrate reductase activity
I6J35_RS01255	COG4585	Histidine kinase
I6J35_RS01260	COG2197	response regulator
I6J35_RS01265	COG2223	nitrite transmembrane transporter activity
I6J35_RS01270	COG3425	synthase
I6J35_RS01290	COG1846	Transcriptional regulator
I6J35_RS01315	COG1611	Belongs to the LOG family
I6J35_RS01335	COG0492	ferredoxin-NADP+ reductase activity
I6J35_RS01340	COG2814	Major facilitator Superfamily
I6J35_RS01345	COG0604	alcohol dehydrogenase
I6J35_RS01355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS01360	COG1620	l-lactate permease
I6J35_RS01365	COG0438	transferase activity, transferring glycosyl groups
I6J35_RS01375	COG3850	Histidine kinase
I6J35_RS01375	COG5002	protein histidine kinase activity
I6J35_RS01380	COG0745	RESPONSE REGULATOR receiver
I6J35_RS01385	COG0577	efflux transmembrane transporter activity
I6J35_RS01390	COG1136	(ABC) transporter
I6J35_RS01410	COG2814	Major facilitator Superfamily
I6J35_RS01415	COG2409	Drug exporters of the RND superfamily
I6J35_RS01415	COG1033	growth of symbiont in host cell
I6J35_RS01425	COG1566	PFAM secretion protein HlyD family protein
I6J35_RS01430	COG2814	Major facilitator Superfamily
I6J35_RS01450	COG0598	Magnesium transport protein CorA
I6J35_RS01455	COG1304	FMN binding
I6J35_RS01465	COG1328	CTP reductase activity
I6J35_RS01470	COG0602	queuosine metabolic process
I6J35_RS01475	COG2094	Belongs to the DNA glycosylase MPG family
I6J35_RS01480	COG3152	Membrane
I6J35_RS01505	COG4152	abc transporter atp-binding protein
I6J35_RS01510	COG1668	transmembrane transport
I6J35_RS01515	COG1742	UPF0060 membrane protein
I6J35_RS01520	COG2017	converts alpha-aldose to the beta-anomer
I6J35_RS01525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J35_RS01530	COG1266	CAAX protease self-immunity
I6J35_RS01535	COG0010	Belongs to the arginase family
I6J35_RS01540	COG0583	DNA-binding transcription factor activity
I6J35_RS01545	COG3314	Sporulation integral membrane protein YlbJ
I6J35_RS01555	COG1228	amidohydrolase
I6J35_RS01560	COG0659	secondary active sulfate transmembrane transporter activity
I6J35_RS01565	COG1473	amidohydrolase
I6J35_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS01575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J35_RS01590	COG2271	Major facilitator Superfamily
I6J35_RS01610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J35_RS01635	COG1113	amino acid transport
I6J35_RS01640	COG1737	Transcriptional regulator
I6J35_RS01665	COG1316	TRANSCRIPTIONal
I6J35_RS01675	COG3383	formate dehydrogenase (NAD+) activity
I6J35_RS01705	COG2076	Multidrug Resistance protein
I6J35_RS01710	COG2076	Multidrug Resistance protein
I6J35_RS01725	COG1757	Na H antiporter
I6J35_RS01735	COG3942	CHAP domain
I6J35_RS01755	COG0829	nickel cation binding
I6J35_RS01765	COG0830	nickel cation binding
I6J35_RS01770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6J35_RS01775	COG0804	urea catabolic process
I6J35_RS01780	COG0832	Belongs to the urease beta subunit family
I6J35_RS01785	COG0831	urea catabolic process
I6J35_RS01795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J35_RS01800	COG1960	acyl-CoA dehydrogenase activity
I6J35_RS01805	COG1957	nucleoside hydrolase
I6J35_RS01810	COG1268	BioY protein
I6J35_RS01820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J35_RS01825	COG1609	Transcriptional regulator
I6J35_RS01830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J35_RS01835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J35_RS01840	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6J35_RS01845	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J35_RS01850	COG4149	molybdate abc transporter
I6J35_RS01855	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J35_RS01860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J35_RS01865	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J35_RS01870	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J35_RS01875	COG0303	'Molybdopterin
I6J35_RS01885	COG0314	molybdopterin synthase activity
I6J35_RS01895	COG0746	molybdenum cofactor guanylyltransferase activity
I6J35_RS01900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J35_RS01915	COG2197	response regulator
I6J35_RS01920	COG2814	Major facilitator Superfamily
I6J35_RS01940	COG2348	transferase activity, transferring amino-acyl groups
I6J35_RS01945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J35_RS01980	COG4975	Glucose uptake
I6J35_RS01990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J35_RS01990	COG0551	DNA topoisomerase type I activity
I6J35_RS01995	COG2252	PERMEase
I6J35_RS02010	COG0051	transcription antitermination factor activity, RNA binding
I6J35_RS02015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J35_RS02020	COG0088	Forms part of the polypeptide exit tunnel
I6J35_RS02025	COG0089	rRNA binding
I6J35_RS02030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J35_RS02035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J35_RS02040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J35_RS02045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J35_RS02050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J35_RS02060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J35_RS02065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J35_RS02070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J35_RS02075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J35_RS02080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J35_RS02085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J35_RS02090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J35_RS02095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J35_RS02100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J35_RS02105	COG1841	ribosomal large subunit assembly
I6J35_RS02110	COG0200	Binds to the 23S rRNA
I6J35_RS02115	COG0201	protein transport
I6J35_RS02120	COG0563	adenylate kinase activity
I6J35_RS02130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J35_RS02135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J35_RS02140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J35_RS02145	COG0202	RNA polymerase activity
I6J35_RS02150	COG0203	ribosomal protein L17
I6J35_RS02170	COG0101	tRNA pseudouridine synthase activity
I6J35_RS02175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J35_RS02180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J35_RS02195	COG1335	isochorismatase
I6J35_RS02220	COG2318	DinB family
I6J35_RS02225	COG0574	Belongs to the PEP-utilizing enzyme family
I6J35_RS02225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J35_RS02230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J35_RS02235	COG2130	NADP-dependent
I6J35_RS02245	COG2130	NADP-dependent
I6J35_RS02250	COG0604	alcohol dehydrogenase
I6J35_RS02255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J35_RS02270	COG1302	Protein conserved in bacteria
I6J35_RS02280	COG2814	Major facilitator Superfamily
I6J35_RS02285	COG4264	IucA IucC family
I6J35_RS02290	COG3457	Alanine racemase
I6J35_RS02295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J35_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS02305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS02310	COG3314	Sporulation integral membrane protein YlbJ
I6J35_RS02315	COG2329	Antibiotic biosynthesis monooxygenase
I6J35_RS02330	COG1988	membrane-bound metal-dependent
I6J35_RS02335	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6J35_RS02340	COG1272	protein, Hemolysin III
I6J35_RS02355	COG2814	Major facilitator Superfamily
I6J35_RS02360	COG0489	protein tyrosine kinase activity
I6J35_RS02410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J35_RS02415	COG4856	YbbR-like protein
I6J35_RS02420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J35_RS02425	COG1285	pathogenesis
I6J35_RS02430	COG0246	Mannitol dehydrogenase
I6J35_RS02435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J35_RS02440	COG3711	transcriptional antiterminator
I6J35_RS02475	COG0640	Transcriptional regulator
I6J35_RS02480	COG0702	epimerase
I6J35_RS02485	COG0702	epimerase
I6J35_RS02490	COG2186	Transcriptional regulator
I6J35_RS02495	COG1482	cell wall glycoprotein biosynthetic process
I6J35_RS02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J35_RS02520	COG0783	Belongs to the Dps family
I6J35_RS02525	COG1876	peptidase activity
I6J35_RS02530	COG0813	purine-nucleoside phosphorylase activity
I6J35_RS02535	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J35_RS02540	COG2348	transferase activity, transferring amino-acyl groups
I6J35_RS02550	COG1854	S-ribosylhomocysteine lyase activity
I6J35_RS02565	COG5146	pantothenate kinase activity
I6J35_RS02575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J35_RS02580	COG3343	RNA polymerase activity
I6J35_RS02585	COG0504	CTP synthase activity
I6J35_RS02595	COG0191	fructose-bisphosphate aldolase activity
I6J35_RS02600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J35_RS02610	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS02615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J35_RS02620	COG0254	rRNA binding
I6J35_RS02625	COG1435	thymidine kinase activity
I6J35_RS02630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J35_RS02635	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J35_RS02640	COG0009	L-threonylcarbamoyladenylate synthase
I6J35_RS02645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J35_RS02650	COG4475	Protein of unknown function (DUF436)
I6J35_RS02655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J35_RS02660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J35_RS02665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J35_RS02675	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J35_RS02680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J35_RS02685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J35_RS02690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J35_RS02700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J35_RS02705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J35_RS02710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J35_RS02715	COG4836	Membrane
I6J35_RS02730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J35_RS02740	COG0629	single-stranded DNA binding
I6J35_RS02745	COG1388	LysM domain
I6J35_RS02750	COG1388	LysM domain
I6J35_RS02755	COG1388	LysM domain
I6J35_RS02760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J35_RS02770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6J35_RS02775	COG0352	thiamine-phosphate diphosphorylase activity
I6J35_RS02780	COG0706	membrane insertase activity
I6J35_RS02790	COG1418	mRNA catabolic process
I6J35_RS02800	COG1937	Protein conserved in bacteria
I6J35_RS02815	COG2217	Heavy metal translocating P-type atpase
I6J35_RS02825	COG0772	Belongs to the SEDS family
I6J35_RS02830	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J35_RS02835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J35_RS02855	COG3402	PFAM membrane-flanked domain
I6J35_RS02860	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J35_RS02865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J35_RS02895	COG1191	sigma factor activity
I6J35_RS02900	COG2183	response to ionizing radiation
I6J35_RS02905	COG3091	SprT-like family
I6J35_RS02940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J35_RS02945	COG0473	3-isopropylmalate dehydrogenase activity
I6J35_RS02950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J35_RS02955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J35_RS02960	COG0440	acetolactate synthase activity
I6J35_RS02965	COG0028	Belongs to the TPP enzyme family
I6J35_RS02970	COG0129	dihydroxy-acid dehydratase activity
I6J35_RS02975	COG0802	atpase or kinase
I6J35_RS02980	COG1214	PFAM Peptidase M22, glycoprotease
I6J35_RS02985	COG0456	acetyltransferase
I6J35_RS02990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J35_RS02995	COG0488	(ABC) transporter
I6J35_RS03000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J35_RS03005	COG0425	Belongs to the sulfur carrier protein TusA family
I6J35_RS03010	COG2391	methyltransferase activity
I6J35_RS03015	COG1621	beta-fructofuranosidase activity
I6J35_RS03020	COG3279	Response regulator of the LytR AlgR family
I6J35_RS03035	COG4512	PFAM Accessory gene regulator B
I6J35_RS03060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J35_RS03065	COG0459	protein refolding
I6J35_RS03095	COG1725	Transcriptional regulator
I6J35_RS03110	COG1131	(ABC) transporter
I6J35_RS03155	COG2706	6-phosphogluconolactonase activity
I6J35_RS03160	COG0471	metal ion transport
I6J35_RS03170	COG1335	isochorismatase
I6J35_RS03175	COG1227	inorganic diphosphatase activity
I6J35_RS03180	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS03185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J35_RS03190	COG0077	Prephenate dehydratase
I6J35_RS03200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J35_RS03205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J35_RS03210	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6J35_RS03220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J35_RS03225	COG4496	protein, YerC YecD
I6J35_RS03230	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6J35_RS03240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J35_RS03245	COG4851	CamS sex pheromone cAM373 precursor
I6J35_RS03255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J35_RS03260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J35_RS03265	COG0154	amidase activity
I6J35_RS03270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J35_RS03275	COG1597	lipid kinase activity
I6J35_RS03290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J35_RS03310	COG4129	membrane
I6J35_RS03335	COG2197	response regulator
I6J35_RS03340	COG0288	reversible hydration of carbon dioxide
I6J35_RS03345	COG1295	ribonuclease BN
I6J35_RS03360	COG4840	Belongs to the UPF0435 family
I6J35_RS03365	COG2309	aminopeptidase activity
I6J35_RS03370	COG1607	acyl-coa hydrolase
I6J35_RS03380	COG0535	radical SAM domain protein
I6J35_RS03395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J35_RS03400	COG2137	regulation of response to DNA damage stimulus
I6J35_RS03410	COG1134	teichoic acid transport
I6J35_RS03410	COG1388	LysM domain
I6J35_RS03420	COG1988	membrane-bound metal-dependent
I6J35_RS03425	COG1194	a g-specific adenine glycosylase
I6J35_RS03430	COG3557	Belongs to the UPF0374 family
I6J35_RS03445	COG4129	membrane
I6J35_RS03450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J35_RS03455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J35_RS03460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J35_RS03465	COG0735	belongs to the Fur family
I6J35_RS03630	COG1126	abc transporter atp-binding protein
I6J35_RS03635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J35_RS03645	COG0363	glucosamine-6-phosphate deaminase activity
I6J35_RS03655	COG0114	fumarate hydratase activity
I6J35_RS03660	COG0564	pseudouridine synthase activity
I6J35_RS03665	COG2203	Gaf domain
I6J35_RS03665	COG4585	Histidine kinase
I6J35_RS03670	COG2197	response regulator
I6J35_RS03675	COG1301	dicarboxylic acid transport
I6J35_RS03685	COG4399	Belongs to the UPF0754 family
I6J35_RS03690	COG3679	Belongs to the UPF0342 family
I6J35_RS03695	COG0420	3'-5' exonuclease activity
I6J35_RS03705	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6J35_RS03710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J35_RS03725	COG0537	adenosine 5'-monophosphoramidase activity
I6J35_RS03730	COG1131	(ABC) transporter
I6J35_RS03735	COG4473	ABC transporter
I6J35_RS03745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J35_RS03750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J35_RS03755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J35_RS03765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J35_RS03770	COG0157	Belongs to the NadC ModD family
I6J35_RS03775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J35_RS03780	COG1104	cysteine desulfurase activity
I6J35_RS03785	COG1827	regulation of RNA biosynthetic process
I6J35_RS03790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J35_RS03860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J35_RS03870	COG1506	peptidase
I6J35_RS03875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J35_RS03880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J35_RS03890	COG0656	L-ascorbic acid biosynthetic process
I6J35_RS03900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J35_RS03915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J35_RS03930	COG1595	DNA-templated transcription, initiation
I6J35_RS03940	COG3266	domain, Protein
I6J35_RS03940	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6J35_RS03940	COG4193	domain, Protein
I6J35_RS03950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J35_RS03950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J35_RS03955	COG0307	riboflavin synthase, alpha
I6J35_RS03960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J35_RS03960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J35_RS03965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J35_RS03970	COG0506	proline dehydrogenase activity
I6J35_RS03975	COG2267	carboxylic ester hydrolase activity
I6J35_RS03980	COG0039	L-malate dehydrogenase activity
I6J35_RS03985	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J35_RS03990	COG1242	4 iron, 4 sulfur cluster binding
I6J35_RS03995	COG2814	Major facilitator Superfamily
I6J35_RS04010	COG2081	HI0933 family
I6J35_RS04015	COG2244	polysaccharide biosynthetic process
I6J35_RS04020	COG1187	pseudouridine synthase activity
I6J35_RS04030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J35_RS04040	COG0510	thiamine kinase activity
I6J35_RS04045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J35_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J35_RS04055	COG5584	Small secreted protein
I6J35_RS04060	COG1363	Peptidase, m42
I6J35_RS04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J35_RS04070	COG4848	Belongs to the UPF0354 family
I6J35_RS04075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J35_RS04080	COG1674	ftsk spoiiie
I6J35_RS04085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J35_RS04090	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6J35_RS04100	COG1605	Chorismate mutase
I6J35_RS04100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J35_RS04105	COG1609	Transcriptional regulator
I6J35_RS04115	COG0454	-acetyltransferase
I6J35_RS04120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J35_RS04125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J35_RS04135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J35_RS04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J35_RS04145	COG0204	Acyl-transferase
I6J35_RS04150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J35_RS04150	COG1263	PTS System
I6J35_RS04160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J35_RS04170	COG1764	response to oxidative stress
I6J35_RS04175	COG0584	glycerophosphoryl diester phosphodiesterase
I6J35_RS04180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J35_RS04185	COG1956	GAF domain-containing protein
I6J35_RS04190	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6J35_RS04195	COG1104	cysteine desulfurase activity
I6J35_RS04200	COG0301	tRNA thio-modification
I6J35_RS04210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J35_RS04215	COG0827	DNA restriction-modification system
I6J35_RS04220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J35_RS04225	COG0589	response to stress
I6J35_RS04230	COG0686	Belongs to the AlaDH PNT family
I6J35_RS04235	COG0006	proline dipeptidase activity
I6J35_RS04240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J35_RS04250	COG4109	DRTGG domain
I6J35_RS04255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J35_RS04265	COG0281	malic enzyme
I6J35_RS04270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J35_RS04275	COG0825	malonyl-CoA metabolic process
I6J35_RS04280	COG0205	6-phosphofructokinase activity
I6J35_RS04285	COG0469	pyruvate kinase activity
I6J35_RS04290	COG1113	amino acid transport
I6J35_RS04295	COG0372	Belongs to the citrate synthase family
I6J35_RS04300	COG0538	isocitrate dehydrogenase activity
I6J35_RS04305	COG0745	RESPONSE REGULATOR receiver
I6J35_RS04310	COG5002	protein histidine kinase activity
I6J35_RS04315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J35_RS04315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J35_RS04320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J35_RS04325	COG0237	dephospho-CoA kinase activity
I6J35_RS04335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J35_RS04340	COG3611	Membrane attachment protein
I6J35_RS04345	COG1484	DNA-dependent DNA replication
I6J35_RS04350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J35_RS04355	COG0833	amino acid
I6J35_RS04360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J35_RS04365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J35_RS04370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J35_RS04375	COG4112	unkown
I6J35_RS04385	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J35_RS04390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J35_RS04395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J35_RS04400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J35_RS04405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J35_RS04410	COG0181	hydroxymethylbilane synthase activity
I6J35_RS04425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J35_RS04430	COG3180	Ammonia monooxygenase
I6J35_RS04435	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J35_RS04440	COG2818	Glycosylase
I6J35_RS04445	COG0525	valine-tRNA ligase activity
I6J35_RS04450	COG0285	dihydrofolate synthase activity
I6J35_RS04460	COG2003	Belongs to the UPF0758 family
I6J35_RS04480	COG1792	Involved in formation and maintenance of cell shape
I6J35_RS04490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J35_RS04495	COG2868	ribosomal protein
I6J35_RS04500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J35_RS04505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J35_RS04510	COG4492	Belongs to the UPF0735 family
I6J35_RS04515	COG0632	four-way junction helicase activity
I6J35_RS04520	COG2255	four-way junction helicase activity
I6J35_RS04525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J35_RS04530	COG0343	queuine tRNA-ribosyltransferase activity
I6J35_RS04535	COG1862	Preprotein translocase
I6J35_RS04540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J35_RS04540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J35_RS04545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J35_RS04545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J35_RS04550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J35_RS04560	COG1490	D-aminoacyl-tRNA deacylase activity
I6J35_RS04565	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J35_RS04570	COG0124	histidyl-tRNA synthetase
I6J35_RS04575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J35_RS04585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J35_RS04590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J35_RS04595	COG1959	2 iron, 2 sulfur cluster binding
I6J35_RS04605	COG3237	CsbD-like
I6J35_RS04610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J35_RS04615	COG1104	cysteine desulfurase activity
I6J35_RS04620	COG0482	sulfurtransferase activity
I6J35_RS04630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J35_RS04635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J35_RS04640	COG4472	Bacterial protein of unknown function (DUF965)
I6J35_RS04645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J35_RS04650	COG3906	Belongs to the UPF0473 family
I6J35_RS04655	COG4122	O-methyltransferase activity
I6J35_RS04660	COG0826	peptidase U32
I6J35_RS04665	COG0826	peptidase U32
I6J35_RS04670	COG0572	uridine kinase
I6J35_RS04675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J35_RS04680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J35_RS04685	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J35_RS04690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J35_RS04695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J35_RS04700	COG1534	Rna-binding protein
I6J35_RS04705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J35_RS04710	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J35_RS04715	COG0799	negative regulation of ribosome biogenesis
I6J35_RS04720	COG2226	methyltransferase
I6J35_RS04725	COG1555	photosystem II stabilization
I6J35_RS04725	COG1596	polysaccharide export
I6J35_RS04730	COG2131	deaminase
I6J35_RS04735	COG0658	competence protein
I6J35_RS04735	COG2333	competence protein COMEC
I6J35_RS04740	COG1466	dna polymerase III delta subunit
I6J35_RS04745	COG0268	Binds directly to 16S ribosomal RNA
I6J35_RS04750	COG0481	GTPase activity
I6J35_RS04755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J35_RS04760	COG1420	regulation of RNA biosynthetic process
I6J35_RS04765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J35_RS04770	COG0443	Heat shock 70 kDa protein
I6J35_RS04775	COG0484	heat shock protein binding
I6J35_RS04780	COG2264	protein methyltransferase activity
I6J35_RS04785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J35_RS04790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J35_RS04805	COG4864	UPF0365 protein
I6J35_RS04815	COG1702	phosphate starvation-inducible protein PhoH
I6J35_RS04820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J35_RS04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J35_RS04840	COG1381	Involved in DNA repair and RecF pathway recombination
I6J35_RS04845	COG0423	glycine-tRNA ligase activity
I6J35_RS04850	COG0517	IMP dehydrogenase activity
I6J35_RS04855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J35_RS04865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J35_RS04870	COG2384	SAM-dependent methyltransferase
I6J35_RS04875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J35_RS04880	COG0513	Belongs to the DEAD box helicase family
I6J35_RS04885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J35_RS04890	COG1121	(ABC) transporter
I6J35_RS04895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J35_RS04910	COG0768	penicillin binding
I6J35_RS04920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J35_RS04930	COG4483	Protein conserved in bacteria
I6J35_RS04935	COG1940	carbohydrate kinase activity
I6J35_RS04940	COG0011	TIGRFAM Protein of
I6J35_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J35_RS04950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J35_RS04955	COG1459	type II secretion system
I6J35_RS04980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J35_RS04985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J35_RS04990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J35_RS04995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J35_RS05000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J35_RS05005	COG0095	Lipoate-protein ligase
I6J35_RS05020	COG0006	proline dipeptidase activity
I6J35_RS05025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J35_RS05030	COG0511	ligase activity, forming carbon-carbon bonds
I6J35_RS05035	COG0439	Biotin carboxylase
I6J35_RS05045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J35_RS05050	COG1570	exodeoxyribonuclease VII activity
I6J35_RS05055	COG1722	exodeoxyribonuclease VII activity
I6J35_RS05065	COG1438	arginine binding
I6J35_RS05070	COG0497	DNA recombination
I6J35_RS05075	COG0280	phosphate acetyltransferase
I6J35_RS05080	COG3426	butyrate kinase activity
I6J35_RS05085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J35_RS05090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J35_RS05095	COG0022	dehydrogenase e1 component
I6J35_RS05100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J35_RS05110	COG4129	membrane
I6J35_RS05115	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J35_RS05120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J35_RS05130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J35_RS05135	COG1234	tRNA 3'-trailer cleavage
I6J35_RS05140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J35_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS05150	COG0667	Aldo Keto reductase
I6J35_RS05155	COG0494	nUDIX hydrolase
I6J35_RS05160	COG0735	belongs to the Fur family
I6J35_RS05165	COG4974	Belongs to the 'phage' integrase family
I6J35_RS05185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J35_RS05190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J35_RS05195	COG1187	pseudouridine synthase activity
I6J35_RS05200	COG0745	RESPONSE REGULATOR receiver
I6J35_RS05215	COG1141	Ferredoxin
I6J35_RS05225	COG0514	ATP-dependent DNA helicase (RecQ)
I6J35_RS05230	COG1388	LysM domain
I6J35_RS05230	COG1388	LysM domain
I6J35_RS05235	COG0492	ferredoxin-NADP+ reductase activity
I6J35_RS05245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J35_RS05250	COG0539	negative regulation of cytoplasmic translation
I6J35_RS05255	COG1160	GTP binding
I6J35_RS05260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J35_RS05275	COG2226	methyltransferase
I6J35_RS05280	COG0142	geranyltranstransferase activity
I6J35_RS05285	COG0105	UTP biosynthetic process
I6J35_RS05290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J35_RS05295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J35_RS05300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J35_RS05305	COG0457	Tetratricopeptide repeat
I6J35_RS05310	COG5582	Belongs to the UPF0302 family
I6J35_RS05315	COG4347	Protein of unknown function (DUF1405)
I6J35_RS05320	COG2738	Putative neutral zinc metallopeptidase
I6J35_RS05325	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J35_RS05330	COG0438	transferase activity, transferring glycosyl groups
I6J35_RS05335	COG0617	tRNA 3'-terminal CCA addition
I6J35_RS05340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J35_RS05340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J35_RS05345	COG1199	ATP-dependent helicase activity
I6J35_RS05345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J35_RS05350	COG0017	Asparaginyl-tRNA synthetase
I6J35_RS05355	COG3935	DnaD domain protein
I6J35_RS05360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J35_RS05370	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J35_RS05370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J35_RS05375	COG3331	DNA recombination
I6J35_RS05385	COG4474	Belongs to the UPF0398 family
I6J35_RS05390	COG3599	regulation of cell shape
I6J35_RS05400	COG0116	Belongs to the methyltransferase superfamily
I6J35_RS05405	COG2962	Rard protein
I6J35_RS05410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J35_RS05415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J35_RS05420	COG0328	RNA-DNA hybrid ribonuclease activity
I6J35_RS05425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J35_RS05435	COG1413	lyase activity
I6J35_RS05465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J35_RS05470	COG2190	(PTS) system
I6J35_RS05475	COG4479	Belongs to the UPF0346 family
I6J35_RS05480	COG0793	Belongs to the peptidase S41A family
I6J35_RS05490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J35_RS05495	COG0671	phosphoesterase, PA-phosphatase related
I6J35_RS05500	COG0745	RESPONSE REGULATOR receiver
I6J35_RS05505	COG5002	protein histidine kinase activity
I6J35_RS05510	COG0567	Dehydrogenase, E1 component
I6J35_RS05530	COG0714	Associated with various cellular activities
I6J35_RS05535	COG4548	von Willebrand factor, type A
I6J35_RS05540	COG1114	Component of the transport system for branched-chain amino acids
I6J35_RS05545	COG1597	lipid kinase activity
I6J35_RS05550	COG3853	Toxic anion resistance protein (TelA)
I6J35_RS05585	COG1473	amidohydrolase
I6J35_RS05590	COG2171	N-acyltransferase activity
I6J35_RS05595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J35_RS05600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J35_RS05605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J35_RS05610	COG0527	aspartate kinase activity
I6J35_RS05615	COG0488	(ABC) transporter
I6J35_RS05620	COG2996	Protein conserved in bacteria
I6J35_RS05625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J35_RS05630	COG0573	inorganic phosphate transmembrane transporter activity
I6J35_RS05635	COG0581	inorganic phosphate transmembrane transporter activity
I6J35_RS05640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J35_RS05645	COG0704	Plays a role in the regulation of phosphate uptake
I6J35_RS05650	COG1164	Oligoendopeptidase f
I6J35_RS05660	COG0747	negative chemotaxis
I6J35_RS05695	COG2348	transferase activity, transferring amino-acyl groups
I6J35_RS05700	COG0159	tryptophan synthase activity
I6J35_RS05710	COG0135	phosphoribosylanthranilate isomerase activity
I6J35_RS05715	COG0134	indole-3-glycerol-phosphate synthase activity
I6J35_RS05720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J35_RS05730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J35_RS05735	COG1363	Peptidase, m42
I6J35_RS05740	COG0287	Prephenate dehydrogenase
I6J35_RS05745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J35_RS05765	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6J35_RS05780	COG0628	permease
I6J35_RS05785	COG1263	PTS System
I6J35_RS05785	COG2190	(PTS) system
I6J35_RS05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J35_RS05790	COG2190	(PTS) system
I6J35_RS05790	COG1263	PTS System
I6J35_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J35_RS05795	COG3711	transcriptional antiterminator
I6J35_RS05800	COG1115	amino acid carrier protein
I6J35_RS05805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J35_RS05815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J35_RS05820	COG4841	protein insertion into membrane
I6J35_RS05825	COG0824	Thioesterase
I6J35_RS05830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J35_RS05835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J35_RS05840	COG1970	mechanosensitive ion channel activity
I6J35_RS05845	COG0419	ATPase involved in DNA repair
I6J35_RS05850	COG0420	3'-5' exonuclease activity
I6J35_RS05855	COG4846	Membrane protein involved in cytochrome C biogenesis
I6J35_RS05860	COG3763	UPF0154 protein
I6J35_RS05865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J35_RS05870	COG4224	UPF0291 protein
I6J35_RS05880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J35_RS05885	COG2340	Cysteine-rich secretory protein family
I6J35_RS05890	COG0516	GMP reductase activity
I6J35_RS05895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J35_RS05905	COG0833	amino acid
I6J35_RS05915	COG0561	phosphatase activity
I6J35_RS05920	COG0083	homoserine kinase activity
I6J35_RS05925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J35_RS05930	COG0460	homoserine dehydrogenase
I6J35_RS05935	COG0527	aspartate kinase activity
I6J35_RS05960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J35_RS05965	COG1525	nuclease
I6J35_RS05975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J35_RS05985	COG0789	Transcriptional regulator
I6J35_RS05995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6J35_RS06000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J35_RS06010	COG1923	regulation of RNA biosynthetic process
I6J35_RS06015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J35_RS06020	COG2267	carboxylic ester hydrolase activity
I6J35_RS06025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J35_RS06030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J35_RS06035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J35_RS06045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J35_RS06055	COG0584	glycerophosphoryl diester phosphodiesterase
I6J35_RS06065	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6J35_RS06070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J35_RS06085	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J35_RS06090	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J35_RS06090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J35_RS06095	COG1692	metallophosphoesterase
I6J35_RS06105	COG0583	DNA-binding transcription factor activity
I6J35_RS06115	COG1418	mRNA catabolic process
I6J35_RS06120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J35_RS06125	COG1058	Belongs to the CinA family
I6J35_RS06125	COG1546	Belongs to the CinA family
I6J35_RS06145	COG0300	oxidoreductase activity
I6J35_RS06150	COG0612	Peptidase, M16
I6J35_RS06155	COG0612	Peptidase, M16
I6J35_RS06160	COG2188	Transcriptional regulator
I6J35_RS06170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J35_RS06175	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J35_RS06180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J35_RS06185	COG0196	riboflavin kinase activity
I6J35_RS06190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J35_RS06195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J35_RS06215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J35_RS06220	COG1358	cellular component organization or biogenesis
I6J35_RS06225	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J35_RS06230	COG0195	Participates in both transcription termination and antitermination
I6J35_RS06235	COG0779	Required for maturation of 30S ribosomal subunits
I6J35_RS06240	COG2176	DNA-directed DNA polymerase activity
I6J35_RS06245	COG0442	prolyl-tRNA aminoacylation
I6J35_RS06255	COG4589	Belongs to the CDS family
I6J35_RS06265	COG0233	cytoplasmic translational termination
I6J35_RS06270	COG0528	UMP kinase activity
I6J35_RS06275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J35_RS06280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J35_RS06285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J35_RS06290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6J35_RS06295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6J35_RS06300	COG4974	Belongs to the 'phage' integrase family
I6J35_RS06305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6J35_RS06310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J35_RS06320	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J35_RS06325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J35_RS06345	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J35_RS06350	COG4485	Bacterial membrane protein, YfhO
I6J35_RS06360	COG4932	domain protein
I6J35_RS06360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J35_RS06360	COG3583	domain protein
I6J35_RS06365	COG0335	large ribosomal subunit rRNA binding
I6J35_RS06370	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J35_RS06375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J35_RS06380	COG0228	four-way junction DNA binding
I6J35_RS06390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J35_RS06395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6J35_RS06400	COG0552	protein localization to endoplasmic reticulum
I6J35_RS06405	COG1196	nuclear chromosome segregation
I6J35_RS06410	COG0571	ribonuclease III activity
I6J35_RS06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J35_RS06430	COG0416	fatty acid biosynthetic process
I6J35_RS06435	COG1349	DNA-binding transcription factor activity
I6J35_RS06440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J35_RS06445	COG1760	l-serine dehydratase
I6J35_RS06450	COG1760	l-serine dehydratase
I6J35_RS06455	COG1461	Dihydroxyacetone kinase
I6J35_RS06460	COG1302	Protein conserved in bacteria
I6J35_RS06465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J35_RS06480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J35_RS06485	COG1162	GTPase activity
I6J35_RS06495	COG0631	protein serine/threonine phosphatase activity
I6J35_RS06500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J35_RS06505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J35_RS06505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J35_RS06510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J35_RS06535	COG2910	NAD(P)H-binding
I6J35_RS06540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J35_RS06545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J35_RS06555	COG1758	RNA polymerase activity
I6J35_RS06560	COG0194	GDP metabolic process
I6J35_RS06590	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J35_RS06595	COG0167	dihydroorotate dehydrogenase activity
I6J35_RS06600	COG0543	2 iron, 2 sulfur cluster binding
I6J35_RS06605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J35_RS06610	COG0505	Belongs to the CarA family
I6J35_RS06620	COG0540	Belongs to the ATCase OTCase family
I6J35_RS06625	COG2233	PERMEase
I6J35_RS06630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J35_RS06635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J35_RS06650	COG0564	pseudouridine synthase activity
I6J35_RS06655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J35_RS06660	COG3942	CHAP domain
I6J35_RS06665	COG2514	catechol 2,3-dioxygenase activity
I6J35_RS06670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J35_RS06675	COG3599	regulation of cell shape
I6J35_RS06685	COG0762	integral membrane protein
I6J35_RS06690	COG1799	cell septum assembly
I6J35_RS06695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J35_RS06700	COG1496	oxidoreductase activity
I6J35_RS06710	COG0849	cell division
I6J35_RS06715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J35_RS06720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J35_RS06725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J35_RS06730	COG0768	penicillin binding
I6J35_RS06735	COG4839	cell division protein FtsL
I6J35_RS06740	COG0275	rRNA processing
I6J35_RS06745	COG2001	Belongs to the MraZ family
I6J35_RS06750	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6J35_RS06755	COG0454	-acetyltransferase
I6J35_RS06760	COG1011	Hydrolase
I6J35_RS06795	COG1388	LysM domain
I6J35_RS06795	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6J35_RS07035	COG0305	Participates in initiation and elongation during chromosome replication
I6J35_RS07145	COG1045	serine acetyltransferase
I6J35_RS07170	COG2153	protein acetylation
I6J35_RS07195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J35_RS07200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J35_RS07215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J35_RS07220	COG1053	succinate dehydrogenase
I6J35_RS07225	COG2009	succinate dehydrogenase
I6J35_RS07230	COG0322	excinuclease ABC activity
I6J35_RS07235	COG3118	belongs to the thioredoxin family
I6J35_RS07240	COG1193	negative regulation of DNA recombination
I6J35_RS07245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J35_RS07245	COG1796	DNA polymerase
I6J35_RS07260	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J35_RS07265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J35_RS07265	COG0072	phenylalanine-tRNA ligase activity
I6J35_RS07270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J35_RS07275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J35_RS07280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J35_RS07290	COG1323	Belongs to the UPF0348 family
I6J35_RS07300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J35_RS07305	COG0742	ribosomal rna small subunit methyltransferase
I6J35_RS07315	COG4471	UPF0298 protein
I6J35_RS07320	COG0584	glycerophosphoryl diester phosphodiesterase
I6J35_RS07325	COG3679	Belongs to the UPF0342 family
I6J35_RS07340	COG0109	protoheme IX farnesyltransferase activity
I6J35_RS07345	COG1612	heme a metabolic process
I6J35_RS07355	COG0772	Belongs to the SEDS family
I6J35_RS07360	COG4838	Belongs to the UPF0358 family
I6J35_RS07365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J35_RS07375	COG1217	gtp-binding protein TYPA
I6J35_RS07385	COG0483	inositol monophosphate 1-phosphatase activity
I6J35_RS07390	COG4493	Belongs to the UPF0637 family
I6J35_RS07395	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J35_RS07415	COG1177	transmembrane transport
I6J35_RS07420	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J35_RS07425	COG3842	ATPase activity
I6J35_RS07435	COG4476	Belongs to the UPF0223 family
I6J35_RS07450	COG0022	dehydrogenase e1 component
I6J35_RS07465	COG0242	peptide deformylase activity
I6J35_RS07475	COG5503	Protein of unknown function (DUF1447)
I6J35_RS07485	COG0569	domain protein
I6J35_RS07490	COG1294	oxidase, subunit
I6J35_RS07495	COG1271	oxidase subunit
I6J35_RS07505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J35_RS07520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J35_RS07535	COG1122	ATPase activity
I6J35_RS07540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6J35_RS07550	COG0151	Belongs to the GarS family
I6J35_RS07555	COG0138	bifunctional purine biosynthesis protein purh
I6J35_RS07560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J35_RS07565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J35_RS07570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J35_RS07575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J35_RS07580	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J35_RS07590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J35_RS07595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J35_RS07600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J35_RS07605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J35_RS07610	COG1363	Peptidase, m42
I6J35_RS07620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J35_RS07620	COG1017	nitric oxide dioxygenase activity
I6J35_RS07630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J35_RS07640	COG1845	cytochrome c oxidase, subunit III
I6J35_RS07645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J35_RS07655	COG1349	DNA-binding transcription factor activity
I6J35_RS07665	COG0698	ribose 5-phosphate isomerase
I6J35_RS07670	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J35_RS07680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J35_RS07685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J35_RS07690	COG2723	6-phospho-beta-galactosidase activity
I6J35_RS07700	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6J35_RS07700	COG1388	LysM domain
I6J35_RS07830	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J35_RS07840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J35_RS07845	COG2369	cell adhesion
I6J35_RS07975	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J35_RS07990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J35_RS07995	COG1316	TRANSCRIPTIONal
I6J35_RS08020	COG3594	Acyltransferase
I6J35_RS08025	COG0436	Aminotransferase
I6J35_RS08030	COG1846	Transcriptional regulator
I6J35_RS08035	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J35_RS08045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J35_RS08050	COG1169	isochorismate synthase
I6J35_RS08055	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J35_RS08065	COG2314	TM2 domain
I6J35_RS08080	COG4873	Protein conserved in bacteria
I6J35_RS08110	COG3177	Filamentation induced by cAMP protein fic
I6J35_RS08120	COG2267	carboxylic ester hydrolase activity
I6J35_RS08130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J35_RS08140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J35_RS08145	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J35_RS08160	COG0107	imidazoleglycerol-phosphate synthase activity
I6J35_RS08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J35_RS08180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J35_RS08185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J35_RS08190	COG0861	Integral membrane protein TerC family
I6J35_RS08195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J35_RS08205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J35_RS08210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J35_RS08215	COG2814	Major facilitator Superfamily
I6J35_RS08225	COG2382	esterase
I6J35_RS08230	COG1115	amino acid carrier protein
I6J35_RS08235	COG0628	permease
I6J35_RS08240	COG2814	Major facilitator Superfamily
I6J35_RS08250	COG0475	glutathione-regulated potassium exporter activity
I6J35_RS08250	COG0569	domain protein
I6J35_RS08255	COG2239	Acts as a magnesium transporter
I6J35_RS08260	COG0564	pseudouridine synthase activity
I6J35_RS08265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J35_RS08270	COG2357	RelA SpoT domain protein
I6J35_RS08280	COG4116	CYTH
I6J35_RS08285	COG2346	COG2346, Truncated hemoglobins
I6J35_RS08290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J35_RS08305	COG1164	Oligoendopeptidase f
I6J35_RS08310	COG4862	establishment of competence for transformation
I6J35_RS08315	COG1393	Belongs to the ArsC family
I6J35_RS08325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J35_RS08330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J35_RS08335	COG4166	transmembrane transport
I6J35_RS08340	COG4608	Belongs to the ABC transporter superfamily
I6J35_RS08345	COG0444	Belongs to the ABC transporter superfamily
I6J35_RS08350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J35_RS08355	COG0601	transmembrane transport
I6J35_RS08375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J35_RS08385	COG0542	response to heat
I6J35_RS08395	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J35_RS08400	COG0561	phosphatase activity
I6J35_RS08405	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J35_RS08415	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J35_RS08420	COG1074	ATP-dependent DNA helicase activity
I6J35_RS08425	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J35_RS08440	COG0398	Pfam SNARE associated Golgi protein
I6J35_RS08450	COG0137	argininosuccinate synthase activity
I6J35_RS08455	COG0165	Argininosuccinate lyase
I6J35_RS08470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J35_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS08480	COG1902	pentaerythritol trinitrate reductase activity
I6J35_RS08495	COG1098	S1 RNA binding domain
I6J35_RS08500	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J35_RS08510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J35_RS08520	COG2111	Na H antiporter
I6J35_RS08520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J35_RS08525	COG2111	Na H antiporter
I6J35_RS08530	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J35_RS08535	COG0651	ATP synthesis coupled electron transport
I6J35_RS08540	COG1863	multisubunit Na H antiporter MnhE subunit
I6J35_RS08545	COG2212	antiporter activity
I6J35_RS08560	COG2050	protein possibly involved in aromatic compounds catabolism
I6J35_RS08565	COG2056	Na+-H+ antiporter family
I6J35_RS08570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J35_RS08575	COG1252	NADH dehydrogenase
I6J35_RS08580	COG0316	Belongs to the HesB IscA family
I6J35_RS08585	COG4844	belongs to the
I6J35_RS08590	COG1252	NADH dehydrogenase
I6J35_RS08600	COG4837	Protein of unknown function (DUF1462)
I6J35_RS08605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6J35_RS08610	COG0789	Transcriptional regulator
I6J35_RS08620	COG2217	Heavy metal translocating P-type atpase
I6J35_RS08625	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6J35_RS08630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J35_RS08635	COG1696	Membrane protein involved in D-alanine export
I6J35_RS08640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J35_RS08650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J35_RS08655	COG0647	UMP catabolic process
I6J35_RS08660	COG2445	Protein of unknown function DUF86
I6J35_RS08670	COG4470	Protein conserved in bacteria
I6J35_RS08675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J35_RS08680	COG0737	Belongs to the 5'-nucleotidase family
I6J35_RS08685	COG0730	response to heat
I6J35_RS08690	COG1801	Protein of unknown function DUF72
I6J35_RS08700	COG4536	flavin adenine dinucleotide binding
I6J35_RS08710	COG0464	growth
I6J35_RS08720	COG0719	Fe-S assembly protein
I6J35_RS08725	COG0822	iron-sulfur transferase activity
I6J35_RS08730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J35_RS08735	COG0719	Fe-S assembly protein
I6J35_RS08740	COG0396	ATPase activity
I6J35_RS08745	COG1464	Belongs to the NlpA lipoprotein family
I6J35_RS08750	COG2011	ABC-type metal ion transport system permease component
I6J35_RS08755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J35_RS08760	COG3118	belongs to the thioredoxin family
I6J35_RS08765	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6J35_RS08770	COG0509	glycine decarboxylation via glycine cleavage system
I6J35_RS08775	COG1393	Belongs to the ArsC family
I6J35_RS08780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J35_RS08790	COG0710	3-dehydroquinate dehydratase activity
I6J35_RS08820	COG1704	LemA family
I6J35_RS08825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J35_RS08845	COG1278	Cold shock
I6J35_RS08860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J35_RS08870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J35_RS08875	COG0557	exoribonuclease II activity
I6J35_RS08880	COG1647	Serine aminopeptidase, S33
I6J35_RS08885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J35_RS08895	COG0148	phosphopyruvate hydratase activity
I6J35_RS08910	COG0126	phosphoglycerate kinase activity
I6J35_RS08915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J35_RS08940	COG0740	serine-type endopeptidase activity
I6J35_RS08950	COG1114	Component of the transport system for branched-chain amino acids
I6J35_RS08955	COG2814	Major facilitator Superfamily
I6J35_RS08960	COG1481	regulation of sporulation
I6J35_RS08965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J35_RS08970	COG1660	Displays ATPase and GTPase activities
I6J35_RS08985	COG0110	maltose O-acetyltransferase activity
I6J35_RS08990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J35_RS08995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6J35_RS09020	COG3942	CHAP domain
I6J35_RS09030	COG0653	protein targeting
I6J35_RS09035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J35_RS09045	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J35_RS09055	COG1739	Uncharacterized protein family UPF0029
I6J35_RS09060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J35_RS09065	COG2199	diguanylate cyclase activity
I6J35_RS09080	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J35_RS09085	COG1929	Belongs to the glycerate kinase type-1 family
I6J35_RS09105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J35_RS09115	COG4607	ABC-type enterochelin transport system periplasmic component
I6J35_RS09120	COG4604	ABC transporter, ATP-binding protein
I6J35_RS09125	COG4605	iron ion homeostasis
I6J35_RS09130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS09135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J35_RS09140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J35_RS09145	COG1780	Probably involved in ribonucleotide reductase function
I6J35_RS09150	COG0697	spore germination
I6J35_RS09155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J35_RS09160	COG3104	oligopeptide transport
I6J35_RS09165	COG3104	oligopeptide transport
I6J35_RS09170	COG2226	methyltransferase
I6J35_RS09180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J35_RS09185	COG1174	glycine betaine transport
I6J35_RS09195	COG0514	ATP-dependent DNA helicase (RecQ)
I6J35_RS09200	COG0488	(ABC) transporter
I6J35_RS09205	COG1368	sulfuric ester hydrolase activity
I6J35_RS09215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J35_RS09220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J35_RS09225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J35_RS09230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J35_RS09230	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J35_RS09235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J35_RS09240	COG0720	synthase
I6J35_RS09245	COG0602	queuosine metabolic process
I6J35_RS09260	COG0656	L-ascorbic acid biosynthetic process
I6J35_RS09265	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6J35_RS09290	COG1253	flavin adenine dinucleotide binding
I6J35_RS09295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J35_RS09295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J35_RS09295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J35_RS09300	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J35_RS09305	COG1349	DNA-binding transcription factor activity
I6J35_RS09310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J35_RS09345	COG0471	metal ion transport
I6J35_RS09350	COG0039	L-malate dehydrogenase activity
I6J35_RS09355	COG0586	Pfam SNARE associated Golgi protein
I6J35_RS09370	COG0523	cobalamin synthesis protein
I6J35_RS09380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J35_RS09385	COG4988	ABC transporter
I6J35_RS09390	COG1968	undecaprenyl-diphosphatase activity
I6J35_RS09400	COG1671	Belongs to the UPF0178 family
I6J35_RS09430	COG2839	Protein conserved in bacteria
I6J35_RS09435	COG2814	Major facilitator Superfamily
I6J35_RS09440	COG0583	DNA-binding transcription factor activity
I6J35_RS09455	COG0217	transcriptional regulatory protein
I6J35_RS09475	COG3942	CHAP domain
I6J35_RS09475	COG1388	LysM domain
I6J35_RS09480	COG1733	regulation of RNA biosynthetic process
I6J35_RS09485	COG2814	Major facilitator Superfamily
I6J35_RS09490	COG0656	L-ascorbic acid biosynthetic process
I6J35_RS09495	COG0306	phosphate transporter
I6J35_RS09500	COG1392	Phosphate transport regulator
I6J35_RS09505	COG0577	efflux transmembrane transporter activity
I6J35_RS09510	COG1136	(ABC) transporter
I6J35_RS09515	COG2205	protein histidine kinase activity
I6J35_RS09530	COG0657	acetylesterase activity
I6J35_RS09535	COG3949	Membrane
I6J35_RS09545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS09550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS09555	COG1120	ATPase activity
I6J35_RS09560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J35_RS09565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J35_RS09570	COG1132	(ABC) transporter
I6J35_RS09575	COG1686	Belongs to the peptidase S11 family
I6J35_RS09580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J35_RS09590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS09595	COG1682	transport, permease protein
I6J35_RS09605	COG5609	conserved protein (DUF2294)
I6J35_RS09610	COG3949	Membrane
I6J35_RS09625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J35_RS09635	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6J35_RS09640	COG0110	maltose O-acetyltransferase activity
I6J35_RS09650	COG1247	-acetyltransferase
I6J35_RS09660	COG1121	(ABC) transporter
I6J35_RS09665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J35_RS09670	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J35_RS09675	COG0025	NhaP-type Na H and K H
I6J35_RS09725	COG0546	phosphoglycolate phosphatase activity
I6J35_RS09730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J35_RS09735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J35_RS09740	COG0018	arginyl-trna synthetase
I6J35_RS09750	COG1473	amidohydrolase
I6J35_RS09775	COG1078	dGTPase activity
I6J35_RS09780	COG0519	Catalyzes the synthesis of GMP from XMP
I6J35_RS09795	COG4844	belongs to the
I6J35_RS09815	COG0095	Lipoate-protein ligase
I6J35_RS09820	COG0280	phosphate acetyltransferase
I6J35_RS09825	COG3253	May function as heme-dependent peroxidase
I6J35_RS09845	COG0586	Pfam SNARE associated Golgi protein
I6J35_RS09850	COG0531	amino acid
I6J35_RS09855	COG2363	Small membrane protein
I6J35_RS09865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J35_RS09875	COG0477	Major facilitator Superfamily
I6J35_RS09880	COG1469	GTP cyclohydrolase I activity
I6J35_RS09885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J35_RS09890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J35_RS09895	COG0363	glucosamine-6-phosphate deaminase activity
I6J35_RS09900	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J35_RS09910	COG0431	NADPH-dependent FMN reductase
I6J35_RS09915	COG0561	phosphatase activity
I6J35_RS09925	COG1428	Deoxynucleoside kinase
I6J35_RS09930	COG1428	Deoxynucleoside kinase
I6J35_RS09935	COG0561	phosphatase activity
I6J35_RS09945	COG0546	phosphoglycolate phosphatase activity
I6J35_RS09950	COG2832	Protein of unknown function (DUF454)
I6J35_RS09955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J35_RS09975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6J35_RS09985	COG1473	amidohydrolase
I6J35_RS09990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J35_RS09995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J35_RS10000	COG0049	tRNA binding
I6J35_RS10005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J35_RS10020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J35_RS10025	COG0085	RNA polymerase activity
I6J35_RS10030	COG2813	Specifically methylates the guanine in position
I6J35_RS10040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J35_RS10045	COG0081	regulation of translation
I6J35_RS10050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J35_RS10055	COG0250	Participates in transcription elongation, termination and antitermination
I6J35_RS10060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J35_RS10065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J35_RS10080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J35_RS10085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6J35_RS10090	COG0215	cysteine-tRNA ligase activity
I6J35_RS10095	COG1045	serine acetyltransferase
I6J35_RS10100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J35_RS10105	COG4956	integral membrane protein (PIN domain superfamily)
I6J35_RS10110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J35_RS10115	COG0542	response to heat
I6J35_RS10120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6J35_RS10125	COG3880	PFAM UvrB UvrC protein
I6J35_RS10135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J35_RS10150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J35_RS10155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J35_RS10160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J35_RS10170	COG2814	Major facilitator Superfamily
I6J35_RS10255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J35_RS10260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J35_RS10265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J35_RS10270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J35_RS10285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J35_RS10290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J35_RS10305	COG1098	S1 RNA binding domain
I6J35_RS10315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J35_RS10320	COG3956	TIGRFAM MazG family protein
I6J35_RS10325	COG2244	polysaccharide biosynthetic process
I6J35_RS10330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J35_RS10335	COG0193	aminoacyl-tRNA hydrolase activity
I6J35_RS10340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J35_RS10345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J35_RS10350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J35_RS10355	COG2088	sporulation resulting in formation of a cellular spore
I6J35_RS10360	COG0251	oxidation-reduction process
I6J35_RS10365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J35_RS10375	COG4466	Protein conserved in bacteria
I6J35_RS10380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J35_RS10385	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6J35_RS10390	COG0084	hydrolase, TatD family'
I6J35_RS10395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J35_RS10395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J35_RS10430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J35_RS10435	COG2827	Endonuclease containing a URI domain
I6J35_RS10440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J35_RS10445	COG4467	Involved in initiation control of chromosome replication
I6J35_RS10450	COG1774	PSP1 C-terminal conserved region
I6J35_RS10455	COG0470	DNA polymerase III
I6J35_RS10460	COG3870	Protein conserved in bacteria
I6J35_RS10465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J35_RS10470	COG1982	Orn Lys Arg decarboxylase major
I6J35_RS10490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J35_RS10495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J35_RS10500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J35_RS10515	COG2814	Major facilitator Superfamily
I6J35_RS10535	COG0640	Transcriptional regulator
I6J35_RS10540	COG2188	Transcriptional regulator
I6J35_RS10545	COG0366	Alpha amylase catalytic
I6J35_RS10550	COG1263	PTS System
I6J35_RS10550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J35_RS10555	COG0346	lactoylglutathione lyase activity
I6J35_RS10565	COG0493	'glutamate synthase
I6J35_RS10570	COG0070	glutamate synthase
I6J35_RS10570	COG0067	glutamate synthase
I6J35_RS10570	COG0069	glutamate synthase activity
I6J35_RS10575	COG0583	DNA-binding transcription factor activity
I6J35_RS10605	COG4841	protein insertion into membrane
I6J35_RS10610	COG0494	nUDIX hydrolase
I6J35_RS10615	COG4841	protein insertion into membrane
I6J35_RS10625	COG0737	Belongs to the 5'-nucleotidase family
I6J35_RS10640	COG3246	L-lysine catabolic process to acetate
I6J35_RS10645	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J35_RS10655	COG1279	arginine transmembrane transporter activity
I6J35_RS10660	COG0626	cystathionine gamma-synthase activity
I6J35_RS10665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J35_RS10670	COG0733	neurotransmitter:sodium symporter activity
I6J35_RS10680	COG1647	Serine aminopeptidase, S33
I6J35_RS10685	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6J35_RS10720	COG0346	lactoylglutathione lyase activity
I6J35_RS10735	COG1695	Transcriptional regulator
I6J35_RS10740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J35_RS10775	COG0529	Catalyzes the synthesis of activated sulfate
I6J35_RS10780	COG2046	Belongs to the sulfate adenylyltransferase family
I6J35_RS10785	COG0730	response to heat
I6J35_RS10790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J35_RS10795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J35_RS10800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J35_RS10805	COG0175	sulfate reduction
I6J35_RS10820	COG1216	Glycosyl transferase, family 2
I6J35_RS10830	COG1131	(ABC) transporter
I6J35_RS10840	COG0535	radical SAM domain protein
I6J35_RS10875	COG1396	sequence-specific DNA binding
I6J35_RS10885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J35_RS10885	COG0519	Catalyzes the synthesis of GMP from XMP
I6J35_RS10890	COG0516	GMP reductase activity
I6J35_RS10890	COG0517	IMP dehydrogenase activity
I6J35_RS10895	COG2233	PERMEase
I6J35_RS10900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J35_RS10925	COG1823	symporter activity
I6J35_RS10930	COG0778	Nitroreductase
I6J35_RS10940	COG0450	alkyl hydroperoxide reductase
I6J35_RS10945	COG3634	alkyl hydroperoxide reductase activity
I6J35_RS10965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J35_RS10970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J35_RS10990	COG4509	Sortase family
I6J35_RS11025	COG1129	ABC transporter
I6J35_RS11045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J35_RS11055	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J35_RS11075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J35_RS11095	COG0012	GTP binding
I6J35_RS11100	COG4481	Protein conserved in bacteria
I6J35_RS11105	COG0668	transmembrane transport
I6J35_RS11110	COG1475	DNA binding
I6J35_RS11115	COG0626	cystathionine gamma-synthase activity
I6J35_RS11120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J35_RS11120	COG0646	methionine synthase
I6J35_RS11125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J35_RS11135	COG0436	Aminotransferase
I6J35_RS11150	COG1475	DNA binding
I6J35_RS11155	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J35_RS11160	COG0445	tRNA wobble uridine modification
I6J35_RS11165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J35_RS11170	COG0594	ribonuclease P activity
I6J35_RS11180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J35_RS11185	COG0592	DNA-directed DNA polymerase activity
I6J35_RS11195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J35_RS11210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J35_RS11225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J35_RS11245	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6J35_RS11250	COG0359	binds to the 23S rRNA
I6J35_RS11255	COG0305	Participates in initiation and elongation during chromosome replication
I6J35_RS11265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J35_RS11280	COG0745	RESPONSE REGULATOR receiver
I6J35_RS11290	COG4863	YycH protein
I6J35_RS11300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J35_RS11305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J35_RS11340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J35_RS11380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J35_RS11400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J35_RS11430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS11435	COG0668	transmembrane transport
I6J35_RS11440	COG3764	Sortase (surface protein transpeptidase)
I6J35_RS11480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J35_RS11525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J35_RS11535	COG4268	DNA restriction-modification system
I6J35_RS11540	COG1401	restriction endodeoxyribonuclease activity
I6J35_RS11560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J35_RS11600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J35_RS11665	COG0640	Transcriptional regulator
I6J35_RS11670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J35_RS11675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J35_RS11690	COG0640	Transcriptional regulator
I6J35_RS11720	COG0076	glutamate decarboxylase activity
I6J35_RS11725	COG1686	Belongs to the peptidase S11 family
I6J35_RS11735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J35_RS11735	COG3711	transcriptional antiterminator
I6J35_RS11740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J35_RS11740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J35_RS11740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J35_RS11745	COG1482	cell wall glycoprotein biosynthetic process
I6J35_RS11755	COG0640	Transcriptional regulator
I6J35_RS11785	COG1395	domain, Protein
I6J35_RS11800	COG3942	CHAP domain
I6J35_RS11800	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J35_RS11850	COG0471	metal ion transport
I6J35_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS11865	COG1136	(ABC) transporter
I6J35_RS11870	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J35_RS11915	COG1869	D-ribose catabolic process
I6J35_RS11930	COG0183	Belongs to the thiolase family
I6J35_RS11940	COG1960	acyl-CoA dehydrogenase activity
I6J35_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
I6J35_RS11960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS11970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J35_RS11975	COG1280	lysine exporter protein (LysE YggA)
I6J35_RS12010	COG0598	Magnesium transport protein CorA
I6J35_RS12015	COG0598	Magnesium transport protein CorA
I6J35_RS12025	COG0363	glucosamine-6-phosphate deaminase activity
I6J35_RS12030	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J35_RS12035	COG0517	IMP dehydrogenase activity
I6J35_RS12035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J35_RS12045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J35_RS12050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J35_RS12065	COG2226	methyltransferase
I6J35_RS12085	COG0778	Nitroreductase
I6J35_RS12110	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS12115	COG0531	amino acid
I6J35_RS12120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J35_RS12125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J35_RS12135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J35_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS12170	COG1012	belongs to the aldehyde dehydrogenase family
I6J35_RS12180	COG2851	Citrate transporter
I6J35_RS12215	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J35_RS12220	COG1064	alcohol dehydrogenase
I6J35_RS12230	COG0730	response to heat
I6J35_RS12245	COG0753	catalase activity
I6J35_RS12250	COG1063	alcohol dehydrogenase
I6J35_RS12260	COG0542	response to heat
I6J35_RS12275	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J35_RS12275	COG1902	pentaerythritol trinitrate reductase activity
I6J35_RS12280	COG0640	Transcriptional regulator
I6J35_RS12310	COG3732	PTS system glucitol sorbitol-specific
I6J35_RS12315	COG3730	PTS system glucitol sorbitol-specific
I6J35_RS12345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J35_RS12385	COG1966	Carbon starvation protein
I6J35_RS12415	COG1054	Belongs to the UPF0176 family
I6J35_RS12435	COG2388	GCN5-related N-acetyl-transferase
I6J35_RS12440	COG0346	lactoylglutathione lyase activity
I6J35_RS12455	COG0789	Transcriptional regulator
I6J35_RS12465	COG0477	Major facilitator Superfamily
I6J35_RS12485	COG0667	Aldo Keto reductase
I6J35_RS12495	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS12500	COG3949	Membrane
I6J35_RS12525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J35_RS12530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS12550	COG1288	antiporter activity
I6J35_RS12560	COG3871	stress protein (general stress protein 26)
I6J35_RS12565	COG1929	Belongs to the glycerate kinase type-1 family
I6J35_RS12570	COG1511	domain protein
I6J35_RS12585	COG0604	alcohol dehydrogenase
I6J35_RS12590	COG0300	oxidoreductase activity
I6J35_RS12600	COG0579	oxidoreductase
I6J35_RS12605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6J35_RS12620	COG0561	phosphatase activity
I6J35_RS12625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J35_RS12630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J35_RS12635	COG1757	Na H antiporter
I6J35_RS12640	COG2326	polyphosphate kinase activity
I6J35_RS12660	COG0596	Alpha beta hydrolase
I6J35_RS12670	COG1288	antiporter activity
I6J35_RS12685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J35_RS12700	COG0706	membrane insertase activity
I6J35_RS12720	COG0583	DNA-binding transcription factor activity
I6J35_RS12725	COG3842	ATPase activity
I6J35_RS12730	COG1840	ABC-type Fe3 transport system, periplasmic component
I6J35_RS12760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J35_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
I6J35_RS12825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J35_RS12840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J35_RS12845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J35_RS12875	COG0069	glutamate synthase activity
I6J35_RS12880	COG2814	Major facilitator Superfamily
I6J35_RS12885	COG2822	iron ion transport
I6J35_RS12890	COG2837	iron assimilation
I6J35_RS12895	COG0672	)-iron permease
I6J35_RS12900	COG0805	protein transport
I6J35_RS12905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J35_RS12910	COG4336	lyase activity
I6J35_RS12915	COG0753	catalase activity
I6J35_RS12925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J35_RS12955	COG0201	protein transport
I6J35_RS12965	COG1073	alpha beta
I6J35_RS12990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J35_RS13020	COG4932	domain protein
I6J35_RS13020	COG3583	domain protein
I6J35_RS13020	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J35_RS13040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J35_RS13045	COG2011	ABC-type metal ion transport system permease component
I6J35_RS13065	COG2207	Transcriptional regulator
I6J35_RS13080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J35_RS13085	COG1063	alcohol dehydrogenase
I6J35_RS13090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS13100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J35_RS13110	COG1511	domain protein
I6J35_RS13145	COG2210	Belongs to the sulfur carrier protein TusA family