locus-tag	class	description
BTZ13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTZ13_RS00010	COG0592	DNA-directed DNA polymerase activity
BTZ13_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BTZ13_RS00025	COG0187	DNA topoisomerase II activity
BTZ13_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTZ13_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTZ13_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BTZ13_RS00075	COG0359	binds to the 23S rRNA
BTZ13_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
BTZ13_RS00090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTZ13_RS00105	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS00115	COG4863	YycH protein
BTZ13_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BTZ13_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTZ13_RS00135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BTZ13_RS00150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTZ13_RS00185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BTZ13_RS00210	COG0640	Transcriptional regulator
BTZ13_RS00215	COG2217	Heavy metal translocating P-type atpase
BTZ13_RS00220	COG2217	Heavy metal translocating P-type atpase
BTZ13_RS00225	COG1388	LysM domain
BTZ13_RS00245	COG0076	glutamate decarboxylase activity
BTZ13_RS00250	COG1686	Belongs to the peptidase S11 family
BTZ13_RS00260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTZ13_RS00260	COG3711	transcriptional antiterminator
BTZ13_RS00265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTZ13_RS00265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTZ13_RS00265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTZ13_RS00270	COG1482	cell wall glycoprotein biosynthetic process
BTZ13_RS00280	COG0640	Transcriptional regulator
BTZ13_RS00310	COG1395	domain, Protein
BTZ13_RS00325	COG1705	Flagellar rod assembly protein muramidase FlgJ
BTZ13_RS00325	COG3942	CHAP domain
BTZ13_RS00375	COG0471	metal ion transport
BTZ13_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS00390	COG1136	(ABC) transporter
BTZ13_RS00395	COG4591	ABC-type transport system involved in lipoprotein release permease component
BTZ13_RS00430	COG1609	Transcriptional regulator
BTZ13_RS00440	COG1869	D-ribose catabolic process
BTZ13_RS00455	COG0183	Belongs to the thiolase family
BTZ13_RS00465	COG1960	acyl-CoA dehydrogenase activity
BTZ13_RS00470	COG0318	PFAM AMP-dependent synthetase and ligase
BTZ13_RS00480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS00490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTZ13_RS00495	COG1280	lysine exporter protein (LysE YggA)
BTZ13_RS00530	COG0598	Magnesium transport protein CorA
BTZ13_RS00535	COG0598	Magnesium transport protein CorA
BTZ13_RS00545	COG0363	glucosamine-6-phosphate deaminase activity
BTZ13_RS00550	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BTZ13_RS00555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BTZ13_RS00555	COG0517	IMP dehydrogenase activity
BTZ13_RS00565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTZ13_RS00570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTZ13_RS00585	COG2226	methyltransferase
BTZ13_RS00605	COG0778	Nitroreductase
BTZ13_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS00635	COG0531	amino acid
BTZ13_RS00640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BTZ13_RS00645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTZ13_RS00655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BTZ13_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS00700	COG2851	Citrate transporter
BTZ13_RS00740	COG1472	Belongs to the glycosyl hydrolase 3 family
BTZ13_RS00745	COG1064	alcohol dehydrogenase
BTZ13_RS00755	COG0730	response to heat
BTZ13_RS00770	COG0753	catalase activity
BTZ13_RS00775	COG1063	alcohol dehydrogenase
BTZ13_RS00785	COG0542	response to heat
BTZ13_RS00800	COG1902	pentaerythritol trinitrate reductase activity
BTZ13_RS00800	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTZ13_RS00805	COG0640	Transcriptional regulator
BTZ13_RS00835	COG3732	PTS system glucitol sorbitol-specific
BTZ13_RS00840	COG3730	PTS system glucitol sorbitol-specific
BTZ13_RS00865	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BTZ13_RS00910	COG1966	Carbon starvation protein
BTZ13_RS00940	COG1054	Belongs to the UPF0176 family
BTZ13_RS00960	COG2388	GCN5-related N-acetyl-transferase
BTZ13_RS00965	COG0346	lactoylglutathione lyase activity
BTZ13_RS00980	COG0789	Transcriptional regulator
BTZ13_RS00990	COG0477	Major facilitator Superfamily
BTZ13_RS01010	COG0667	Aldo Keto reductase
BTZ13_RS01020	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS01025	COG3949	Membrane
BTZ13_RS01060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTZ13_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS01085	COG1288	antiporter activity
BTZ13_RS01095	COG3871	stress protein (general stress protein 26)
BTZ13_RS01100	COG1929	Belongs to the glycerate kinase type-1 family
BTZ13_RS01105	COG1511	domain protein
BTZ13_RS01120	COG0604	alcohol dehydrogenase
BTZ13_RS01125	COG0300	oxidoreductase activity
BTZ13_RS01140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BTZ13_RS01155	COG0561	phosphatase activity
BTZ13_RS01160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTZ13_RS01165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTZ13_RS01170	COG1757	Na H antiporter
BTZ13_RS01175	COG2326	polyphosphate kinase activity
BTZ13_RS01195	COG0596	Alpha beta hydrolase
BTZ13_RS01205	COG4195	phage-related replication protein
BTZ13_RS01215	COG2348	transferase activity, transferring amino-acyl groups
BTZ13_RS01240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTZ13_RS01250	COG0210	DNA helicase
BTZ13_RS01270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTZ13_RS01275	COG0549	Belongs to the carbamate kinase family
BTZ13_RS01280	COG1288	antiporter activity
BTZ13_RS01290	COG1288	antiporter activity
BTZ13_RS01300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTZ13_RS01315	COG0706	membrane insertase activity
BTZ13_RS01335	COG0583	DNA-binding transcription factor activity
BTZ13_RS01340	COG3842	ATPase activity
BTZ13_RS01345	COG1840	ABC-type Fe3 transport system, periplasmic component
BTZ13_RS01375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTZ13_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS01440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BTZ13_RS01455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BTZ13_RS01460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTZ13_RS01490	COG0069	glutamate synthase activity
BTZ13_RS01495	COG2814	Major facilitator Superfamily
BTZ13_RS01500	COG2822	iron ion transport
BTZ13_RS01505	COG2837	iron assimilation
BTZ13_RS01510	COG0672	)-iron permease
BTZ13_RS01515	COG0805	protein transport
BTZ13_RS01520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTZ13_RS01525	COG4336	lyase activity
BTZ13_RS01530	COG0753	catalase activity
BTZ13_RS01540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BTZ13_RS01570	COG0201	protein transport
BTZ13_RS01580	COG1073	alpha beta
BTZ13_RS01605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BTZ13_RS01635	COG4932	domain protein
BTZ13_RS01635	COG3583	domain protein
BTZ13_RS01635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BTZ13_RS01650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTZ13_RS01655	COG2011	ABC-type metal ion transport system permease component
BTZ13_RS01675	COG2207	Transcriptional regulator
BTZ13_RS01695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTZ13_RS01700	COG1063	alcohol dehydrogenase
BTZ13_RS01705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS01715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS01725	COG1511	domain protein
BTZ13_RS01760	COG2210	Belongs to the sulfur carrier protein TusA family
BTZ13_RS01780	COG3961	Belongs to the TPP enzyme family
BTZ13_RS01790	COG1510	regulation of RNA biosynthetic process
BTZ13_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS01800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BTZ13_RS01805	COG3266	domain, Protein
BTZ13_RS01805	COG4932	domain protein
BTZ13_RS01805	COG4932	domain protein
BTZ13_RS01805	COG3266	domain, Protein
BTZ13_RS01805	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BTZ13_RS01805	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BTZ13_RS01810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTZ13_RS01815	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTZ13_RS01845	COG1368	sulfuric ester hydrolase activity
BTZ13_RS01855	COG2409	Drug exporters of the RND superfamily
BTZ13_RS01860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS01860	COG0463	Glycosyl transferase, family 2
BTZ13_RS01870	COG0494	nUDIX hydrolase
BTZ13_RS01885	COG3588	fructose-bisphosphate aldolase
BTZ13_RS01890	COG2258	MOSC domain
BTZ13_RS01915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BTZ13_RS01920	COG1263	PTS System
BTZ13_RS01920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTZ13_RS01925	COG1737	Transcriptional regulator
BTZ13_RS01965	COG0582	viral genome integration into host DNA
BTZ13_RS01970	COG2111	Na H antiporter
BTZ13_RS01970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTZ13_RS01975	COG2111	Na H antiporter
BTZ13_RS01980	COG1006	Multisubunit Na H antiporter MnhC subunit
BTZ13_RS01990	COG1863	multisubunit Na H antiporter MnhE subunit
BTZ13_RS01995	COG2212	antiporter activity
BTZ13_RS02000	COG1320	monovalent cation:proton antiporter activity
BTZ13_RS02015	COG1113	amino acid transport
BTZ13_RS02025	COG1131	(ABC) transporter
BTZ13_RS02035	COG2824	Alkylphosphonate utilization operon protein PhnA
BTZ13_RS02045	COG2376	Dihydroxyacetone kinase
BTZ13_RS02050	COG1461	Dihydroxyacetone kinase
BTZ13_RS02060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BTZ13_RS02065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS02070	COG0438	transferase activity, transferring glycosyl groups
BTZ13_RS02080	COG0438	transferase activity, transferring glycosyl groups
BTZ13_RS02085	COG0463	Glycosyl transferase, family 2
BTZ13_RS02085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS02090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTZ13_RS02095	COG0531	amino acid
BTZ13_RS02120	COG0463	Glycosyl transferase, family 2
BTZ13_RS02125	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTZ13_RS02135	COG1959	2 iron, 2 sulfur cluster binding
BTZ13_RS02140	COG1131	(ABC) transporter
BTZ13_RS02175	COG0318	PFAM AMP-dependent synthetase and ligase
BTZ13_RS02190	COG2235	arginine
BTZ13_RS02195	COG2235	arginine
BTZ13_RS02205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTZ13_RS02210	COG1438	arginine binding
BTZ13_RS02220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTZ13_RS02225	COG2022	thiamine diphosphate biosynthetic process
BTZ13_RS02235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTZ13_RS02240	COG0352	thiamine-phosphate diphosphorylase activity
BTZ13_RS02250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTZ13_RS02255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTZ13_RS02260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTZ13_RS02280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BTZ13_RS02295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTZ13_RS02305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTZ13_RS02310	COG2807	transmembrane transport
BTZ13_RS02315	COG5646	InterPro IPR014922
BTZ13_RS02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTZ13_RS02335	COG1984	allophanate hydrolase subunit 2
BTZ13_RS02345	COG0439	Biotin carboxylase
BTZ13_RS02350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BTZ13_RS02355	COG1914	H( )-stimulated, divalent metal cation uptake system
BTZ13_RS02360	COG1070	Carbohydrate kinase
BTZ13_RS02375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTZ13_RS02385	COG1695	Transcriptional regulator
BTZ13_RS02430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTZ13_RS02445	COG3189	MarR family transcriptional regulator
BTZ13_RS02455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BTZ13_RS02470	COG0604	alcohol dehydrogenase
BTZ13_RS02475	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BTZ13_RS02480	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BTZ13_RS02490	COG3001	Fructosamine kinase
BTZ13_RS02505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BTZ13_RS02520	COG3764	Sortase (surface protein transpeptidase)
BTZ13_RS02525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTZ13_RS02565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTZ13_RS02585	COG1136	(ABC) transporter
BTZ13_RS02590	COG0577	efflux transmembrane transporter activity
BTZ13_RS02595	COG0583	DNA-binding transcription factor activity
BTZ13_RS02610	COG0028	Belongs to the TPP enzyme family
BTZ13_RS02620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTZ13_RS02630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BTZ13_RS02635	COG1687	branched-chain amino acid
BTZ13_RS02640	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BTZ13_RS02665	COG1760	l-serine dehydratase
BTZ13_RS02670	COG1760	l-serine dehydratase
BTZ13_RS02685	COG0778	Nitroreductase
BTZ13_RS02695	COG1132	(ABC) transporter
BTZ13_RS02700	COG1132	(ABC) transporter
BTZ13_RS02710	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTZ13_RS02715	COG1846	Transcriptional regulator
BTZ13_RS02720	COG0346	lactoylglutathione lyase activity
BTZ13_RS02725	COG2211	Major facilitator Superfamily
BTZ13_RS02730	COG2207	Transcriptional regulator
BTZ13_RS02735	COG3250	beta-galactosidase activity
BTZ13_RS02740	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BTZ13_RS02745	COG1131	(ABC) transporter
BTZ13_RS02755	COG0586	Pfam SNARE associated Golgi protein
BTZ13_RS02760	COG2271	Major facilitator Superfamily
BTZ13_RS02765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BTZ13_RS02770	COG3527	Alpha-acetolactate decarboxylase
BTZ13_RS02780	COG4876	unkown
BTZ13_RS02785	COG0523	cobalamin synthesis protein
BTZ13_RS02790	COG2357	RelA SpoT domain protein
BTZ13_RS02805	COG2808	Putative FMN-binding domain
BTZ13_RS02810	COG1802	Transcriptional regulator
BTZ13_RS02815	COG1070	Carbohydrate kinase
BTZ13_RS02820	COG2610	gluconate transmembrane transporter activity
BTZ13_RS02830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTZ13_RS02835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTZ13_RS02860	COG4619	ABC transporter
BTZ13_RS02865	COG0390	transport system, permease component
BTZ13_RS02870	COG2814	Major facilitator Superfamily
BTZ13_RS02875	COG2272	Belongs to the type-B carboxylesterase lipase family
BTZ13_RS02880	COG0531	amino acid
BTZ13_RS02885	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BTZ13_RS02895	COG1174	glycine betaine transport
BTZ13_RS02905	COG1174	glycine betaine transport
BTZ13_RS02915	COG1309	transcriptional regulator
BTZ13_RS02930	COG1346	cytolysis
BTZ13_RS02940	COG3279	Response regulator of the LytR AlgR family
BTZ13_RS02945	COG3275	phosphorelay sensor kinase activity
BTZ13_RS02960	COG0531	amino acid
BTZ13_RS02965	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BTZ13_RS02970	COG1113	amino acid transport
BTZ13_RS02980	COG2814	Major facilitator Superfamily
BTZ13_RS02990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BTZ13_RS02995	COG0741	lytic transglycosylase activity
BTZ13_RS03000	COG0588	phosphoglycerate mutase activity
BTZ13_RS03005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTZ13_RS03010	COG0765	amino acid transport
BTZ13_RS03015	COG1126	abc transporter atp-binding protein
BTZ13_RS03055	COG2116	formate transmembrane transporter activity
BTZ13_RS03070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BTZ13_RS03075	COG2146	nitrite reductase [NAD(P)H] activity
BTZ13_RS03080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTZ13_RS03080	COG1648	precorrin-2 dehydrogenase activity
BTZ13_RS03085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BTZ13_RS03090	COG1140	nitrate reductase beta subunit
BTZ13_RS03100	COG2181	nitrate reductase activity
BTZ13_RS03110	COG4585	Histidine kinase
BTZ13_RS03115	COG2197	response regulator
BTZ13_RS03120	COG2223	nitrite transmembrane transporter activity
BTZ13_RS03125	COG3425	synthase
BTZ13_RS03145	COG1846	Transcriptional regulator
BTZ13_RS03155	COG0697	spore germination
BTZ13_RS03170	COG1611	Belongs to the LOG family
BTZ13_RS03190	COG0492	ferredoxin-NADP+ reductase activity
BTZ13_RS03195	COG2814	Major facilitator Superfamily
BTZ13_RS03200	COG0604	alcohol dehydrogenase
BTZ13_RS03210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS03215	COG1620	l-lactate permease
BTZ13_RS03220	COG0438	transferase activity, transferring glycosyl groups
BTZ13_RS03230	COG3850	Histidine kinase
BTZ13_RS03230	COG5002	protein histidine kinase activity
BTZ13_RS03235	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS03240	COG0577	efflux transmembrane transporter activity
BTZ13_RS03245	COG1136	(ABC) transporter
BTZ13_RS03265	COG2814	Major facilitator Superfamily
BTZ13_RS03270	COG1033	growth of symbiont in host cell
BTZ13_RS03270	COG2409	Drug exporters of the RND superfamily
BTZ13_RS03280	COG1566	PFAM secretion protein HlyD family protein
BTZ13_RS03285	COG2814	Major facilitator Superfamily
BTZ13_RS03305	COG0598	Magnesium transport protein CorA
BTZ13_RS03310	COG1304	FMN binding
BTZ13_RS03320	COG1328	CTP reductase activity
BTZ13_RS03325	COG0602	queuosine metabolic process
BTZ13_RS03330	COG2094	Belongs to the DNA glycosylase MPG family
BTZ13_RS03335	COG3152	Membrane
BTZ13_RS03360	COG4152	abc transporter atp-binding protein
BTZ13_RS03365	COG1668	transmembrane transport
BTZ13_RS03370	COG1742	UPF0060 membrane protein
BTZ13_RS03375	COG2017	converts alpha-aldose to the beta-anomer
BTZ13_RS03380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTZ13_RS03385	COG1266	CAAX protease self-immunity
BTZ13_RS03390	COG0010	Belongs to the arginase family
BTZ13_RS03395	COG0583	DNA-binding transcription factor activity
BTZ13_RS03400	COG3314	Sporulation integral membrane protein YlbJ
BTZ13_RS03410	COG1228	amidohydrolase
BTZ13_RS03415	COG0659	secondary active sulfate transmembrane transporter activity
BTZ13_RS03420	COG1473	amidohydrolase
BTZ13_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS03430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTZ13_RS03445	COG2271	Major facilitator Superfamily
BTZ13_RS03465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTZ13_RS03490	COG1113	amino acid transport
BTZ13_RS03495	COG1737	Transcriptional regulator
BTZ13_RS03520	COG1316	TRANSCRIPTIONal
BTZ13_RS03530	COG3383	formate dehydrogenase (NAD+) activity
BTZ13_RS03555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTZ13_RS03560	COG2076	Multidrug Resistance protein
BTZ13_RS03565	COG2076	Multidrug Resistance protein
BTZ13_RS03580	COG1757	Na H antiporter
BTZ13_RS03590	COG3942	CHAP domain
BTZ13_RS03610	COG0829	nickel cation binding
BTZ13_RS03620	COG0830	nickel cation binding
BTZ13_RS03625	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BTZ13_RS03630	COG0804	urea catabolic process
BTZ13_RS03635	COG0832	Belongs to the urease beta subunit family
BTZ13_RS03640	COG0831	urea catabolic process
BTZ13_RS03650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTZ13_RS03655	COG1960	acyl-CoA dehydrogenase activity
BTZ13_RS03660	COG1957	nucleoside hydrolase
BTZ13_RS03665	COG1268	BioY protein
BTZ13_RS03675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BTZ13_RS03680	COG1609	Transcriptional regulator
BTZ13_RS03685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BTZ13_RS03690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BTZ13_RS03695	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BTZ13_RS03700	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTZ13_RS03705	COG4149	molybdate abc transporter
BTZ13_RS03710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BTZ13_RS03715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTZ13_RS03720	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTZ13_RS03725	COG0315	cyclic pyranopterin monophosphate synthase activity
BTZ13_RS03730	COG0303	'Molybdopterin
BTZ13_RS03740	COG0314	molybdopterin synthase activity
BTZ13_RS03750	COG0746	molybdenum cofactor guanylyltransferase activity
BTZ13_RS03755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTZ13_RS03770	COG2197	response regulator
BTZ13_RS03775	COG2814	Major facilitator Superfamily
BTZ13_RS03795	COG2348	transferase activity, transferring amino-acyl groups
BTZ13_RS03800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTZ13_RS03830	COG4975	Glucose uptake
BTZ13_RS03840	COG0551	DNA topoisomerase type I activity
BTZ13_RS03840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTZ13_RS03845	COG2252	PERMEase
BTZ13_RS03860	COG0051	transcription antitermination factor activity, RNA binding
BTZ13_RS03865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTZ13_RS03870	COG0088	Forms part of the polypeptide exit tunnel
BTZ13_RS03875	COG0089	rRNA binding
BTZ13_RS03880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTZ13_RS03885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTZ13_RS03890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTZ13_RS03895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTZ13_RS03900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTZ13_RS03910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTZ13_RS03915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTZ13_RS03920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTZ13_RS03925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTZ13_RS03930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTZ13_RS03935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTZ13_RS03940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTZ13_RS03945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTZ13_RS03950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTZ13_RS03955	COG1841	ribosomal large subunit assembly
BTZ13_RS03960	COG0200	Binds to the 23S rRNA
BTZ13_RS03965	COG0201	protein transport
BTZ13_RS03970	COG0563	adenylate kinase activity
BTZ13_RS03980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTZ13_RS03985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTZ13_RS03990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTZ13_RS03995	COG0202	RNA polymerase activity
BTZ13_RS04000	COG0203	ribosomal protein L17
BTZ13_RS04020	COG0101	tRNA pseudouridine synthase activity
BTZ13_RS04025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTZ13_RS04030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTZ13_RS04045	COG1335	isochorismatase
BTZ13_RS04070	COG2318	DinB family
BTZ13_RS04075	COG0574	Belongs to the PEP-utilizing enzyme family
BTZ13_RS04075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTZ13_RS04080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTZ13_RS04085	COG2130	NADP-dependent
BTZ13_RS04095	COG2130	NADP-dependent
BTZ13_RS04100	COG0604	alcohol dehydrogenase
BTZ13_RS04105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTZ13_RS04120	COG1302	Protein conserved in bacteria
BTZ13_RS04130	COG2814	Major facilitator Superfamily
BTZ13_RS04135	COG4264	IucA IucC family
BTZ13_RS04140	COG3457	Alanine racemase
BTZ13_RS04145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BTZ13_RS04150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS04155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS04160	COG3314	Sporulation integral membrane protein YlbJ
BTZ13_RS04165	COG2329	Antibiotic biosynthesis monooxygenase
BTZ13_RS04180	COG1988	membrane-bound metal-dependent
BTZ13_RS04185	COG4284	Utp--glucose-1-phosphate uridylyltransferase
BTZ13_RS04190	COG1272	protein, Hemolysin III
BTZ13_RS04205	COG2814	Major facilitator Superfamily
BTZ13_RS04210	COG0489	protein tyrosine kinase activity
BTZ13_RS04260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BTZ13_RS04265	COG4856	YbbR-like protein
BTZ13_RS04270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTZ13_RS04275	COG1285	pathogenesis
BTZ13_RS04280	COG0246	Mannitol dehydrogenase
BTZ13_RS04285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTZ13_RS04290	COG3711	transcriptional antiterminator
BTZ13_RS04325	COG0640	Transcriptional regulator
BTZ13_RS04330	COG0702	epimerase
BTZ13_RS04335	COG0702	epimerase
BTZ13_RS04340	COG2186	Transcriptional regulator
BTZ13_RS04345	COG1482	cell wall glycoprotein biosynthetic process
BTZ13_RS04365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTZ13_RS04370	COG0783	Belongs to the Dps family
BTZ13_RS04375	COG1876	peptidase activity
BTZ13_RS04380	COG0813	purine-nucleoside phosphorylase activity
BTZ13_RS04385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BTZ13_RS04390	COG2348	transferase activity, transferring amino-acyl groups
BTZ13_RS04400	COG1854	S-ribosylhomocysteine lyase activity
BTZ13_RS04415	COG5146	pantothenate kinase activity
BTZ13_RS04425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTZ13_RS04430	COG3343	RNA polymerase activity
BTZ13_RS04435	COG0504	CTP synthase activity
BTZ13_RS04445	COG0191	fructose-bisphosphate aldolase activity
BTZ13_RS04450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTZ13_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS04465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTZ13_RS04470	COG0254	rRNA binding
BTZ13_RS04475	COG1435	thymidine kinase activity
BTZ13_RS04480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTZ13_RS04485	COG2890	protein-(glutamine-N5) methyltransferase activity
BTZ13_RS04490	COG0009	L-threonylcarbamoyladenylate synthase
BTZ13_RS04495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTZ13_RS04500	COG4475	Protein of unknown function (DUF436)
BTZ13_RS04505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTZ13_RS04510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTZ13_RS04515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BTZ13_RS04525	COG0356	it plays a direct role in the translocation of protons across the membrane
BTZ13_RS04530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTZ13_RS04535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTZ13_RS04540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTZ13_RS04550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTZ13_RS04555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTZ13_RS04560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTZ13_RS04565	COG4836	Membrane
BTZ13_RS04580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTZ13_RS04590	COG0629	single-stranded DNA binding
BTZ13_RS04595	COG1388	LysM domain
BTZ13_RS04600	COG1388	LysM domain
BTZ13_RS04605	COG1388	LysM domain
BTZ13_RS04610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BTZ13_RS04620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BTZ13_RS04625	COG0352	thiamine-phosphate diphosphorylase activity
BTZ13_RS04630	COG0706	membrane insertase activity
BTZ13_RS04640	COG1418	mRNA catabolic process
BTZ13_RS04645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTZ13_RS04650	COG1937	Protein conserved in bacteria
BTZ13_RS04665	COG2217	Heavy metal translocating P-type atpase
BTZ13_RS04670	COG0772	Belongs to the SEDS family
BTZ13_RS04675	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTZ13_RS04680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BTZ13_RS04700	COG3402	PFAM membrane-flanked domain
BTZ13_RS04705	COG0736	holo-[acyl-carrier-protein] synthase activity
BTZ13_RS04710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTZ13_RS04725	COG2208	phosphoserine phosphatase activity
BTZ13_RS04740	COG1191	sigma factor activity
BTZ13_RS04745	COG2183	response to ionizing radiation
BTZ13_RS04750	COG3091	SprT-like family
BTZ13_RS04785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTZ13_RS04790	COG0473	3-isopropylmalate dehydrogenase activity
BTZ13_RS04795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTZ13_RS04800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BTZ13_RS04805	COG0440	acetolactate synthase activity
BTZ13_RS04810	COG0028	Belongs to the TPP enzyme family
BTZ13_RS04815	COG0129	dihydroxy-acid dehydratase activity
BTZ13_RS04820	COG0802	atpase or kinase
BTZ13_RS04825	COG1214	PFAM Peptidase M22, glycoprotease
BTZ13_RS04830	COG0456	acetyltransferase
BTZ13_RS04835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTZ13_RS04840	COG0488	(ABC) transporter
BTZ13_RS04845	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BTZ13_RS04850	COG0425	Belongs to the sulfur carrier protein TusA family
BTZ13_RS04855	COG2391	methyltransferase activity
BTZ13_RS04860	COG1621	beta-fructofuranosidase activity
BTZ13_RS04865	COG3279	Response regulator of the LytR AlgR family
BTZ13_RS04880	COG4512	PFAM Accessory gene regulator B
BTZ13_RS04905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTZ13_RS04910	COG0459	protein refolding
BTZ13_RS04915	COG0582	viral genome integration into host DNA
BTZ13_RS05050	COG1725	Transcriptional regulator
BTZ13_RS05065	COG1131	(ABC) transporter
BTZ13_RS05110	COG2706	6-phosphogluconolactonase activity
BTZ13_RS05115	COG0471	metal ion transport
BTZ13_RS05125	COG1335	isochorismatase
BTZ13_RS05130	COG1227	inorganic diphosphatase activity
BTZ13_RS05135	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS05140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTZ13_RS05145	COG0077	Prephenate dehydratase
BTZ13_RS05155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTZ13_RS05160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTZ13_RS05165	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BTZ13_RS05175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTZ13_RS05180	COG4496	protein, YerC YecD
BTZ13_RS05185	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BTZ13_RS05195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTZ13_RS05200	COG4851	CamS sex pheromone cAM373 precursor
BTZ13_RS05210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTZ13_RS05215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTZ13_RS05220	COG0154	amidase activity
BTZ13_RS05225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTZ13_RS05235	COG1597	lipid kinase activity
BTZ13_RS05250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTZ13_RS05270	COG4129	membrane
BTZ13_RS05295	COG2197	response regulator
BTZ13_RS05300	COG0288	reversible hydration of carbon dioxide
BTZ13_RS05305	COG1295	ribonuclease BN
BTZ13_RS05320	COG4840	Belongs to the UPF0435 family
BTZ13_RS05325	COG2309	aminopeptidase activity
BTZ13_RS05330	COG1607	acyl-coa hydrolase
BTZ13_RS05340	COG0535	radical SAM domain protein
BTZ13_RS05350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTZ13_RS05355	COG2137	regulation of response to DNA damage stimulus
BTZ13_RS05365	COG1134	teichoic acid transport
BTZ13_RS05365	COG1388	LysM domain
BTZ13_RS05375	COG1988	membrane-bound metal-dependent
BTZ13_RS05380	COG1194	a g-specific adenine glycosylase
BTZ13_RS05385	COG3557	Belongs to the UPF0374 family
BTZ13_RS05400	COG4129	membrane
BTZ13_RS05405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTZ13_RS05410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTZ13_RS05415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTZ13_RS05420	COG0735	belongs to the Fur family
BTZ13_RS05565	COG0765	amino acid transport
BTZ13_RS05570	COG1126	abc transporter atp-binding protein
BTZ13_RS05575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTZ13_RS05585	COG0363	glucosamine-6-phosphate deaminase activity
BTZ13_RS05595	COG0114	fumarate hydratase activity
BTZ13_RS05600	COG0564	pseudouridine synthase activity
BTZ13_RS05605	COG2203	Gaf domain
BTZ13_RS05605	COG4585	Histidine kinase
BTZ13_RS05610	COG2197	response regulator
BTZ13_RS05615	COG1301	dicarboxylic acid transport
BTZ13_RS05625	COG4399	Belongs to the UPF0754 family
BTZ13_RS05630	COG3679	Belongs to the UPF0342 family
BTZ13_RS05635	COG0420	3'-5' exonuclease activity
BTZ13_RS05645	COG3481	metal-dependent phosphohydrolase, HD sub domain
BTZ13_RS05650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTZ13_RS05665	COG0537	adenosine 5'-monophosphoramidase activity
BTZ13_RS05670	COG1131	(ABC) transporter
BTZ13_RS05675	COG4473	ABC transporter
BTZ13_RS05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTZ13_RS05690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTZ13_RS05695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BTZ13_RS05705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BTZ13_RS05710	COG0157	Belongs to the NadC ModD family
BTZ13_RS05715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BTZ13_RS05720	COG1104	cysteine desulfurase activity
BTZ13_RS05725	COG1827	regulation of RNA biosynthetic process
BTZ13_RS05730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTZ13_RS05805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTZ13_RS05815	COG1506	peptidase
BTZ13_RS05820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BTZ13_RS05825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTZ13_RS05835	COG0656	L-ascorbic acid biosynthetic process
BTZ13_RS05845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTZ13_RS05860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTZ13_RS05875	COG1595	DNA-templated transcription, initiation
BTZ13_RS05885	COG5632	N-Acetylmuramoyl-L-alanine amidase
BTZ13_RS05885	COG3266	domain, Protein
BTZ13_RS05885	COG4193	domain, Protein
BTZ13_RS05895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTZ13_RS05895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTZ13_RS05900	COG0307	riboflavin synthase, alpha
BTZ13_RS05905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BTZ13_RS05905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BTZ13_RS05910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTZ13_RS05915	COG0506	proline dehydrogenase activity
BTZ13_RS05920	COG2267	carboxylic ester hydrolase activity
BTZ13_RS05925	COG0039	L-malate dehydrogenase activity
BTZ13_RS05930	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BTZ13_RS05935	COG1242	4 iron, 4 sulfur cluster binding
BTZ13_RS05940	COG2814	Major facilitator Superfamily
BTZ13_RS05955	COG2081	HI0933 family
BTZ13_RS05960	COG2244	polysaccharide biosynthetic process
BTZ13_RS05965	COG1187	pseudouridine synthase activity
BTZ13_RS05975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTZ13_RS05985	COG0510	thiamine kinase activity
BTZ13_RS05990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTZ13_RS05995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTZ13_RS06000	COG5584	Small secreted protein
BTZ13_RS06005	COG1363	Peptidase, m42
BTZ13_RS06010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTZ13_RS06015	COG4848	Belongs to the UPF0354 family
BTZ13_RS06020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTZ13_RS06025	COG1674	ftsk spoiiie
BTZ13_RS06030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTZ13_RS06035	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BTZ13_RS06045	COG1605	Chorismate mutase
BTZ13_RS06045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BTZ13_RS06050	COG1609	Transcriptional regulator
BTZ13_RS06060	COG0454	-acetyltransferase
BTZ13_RS06065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTZ13_RS06070	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BTZ13_RS06080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTZ13_RS06085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTZ13_RS06090	COG0204	Acyl-transferase
BTZ13_RS06095	COG1263	PTS System
BTZ13_RS06095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTZ13_RS06105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTZ13_RS06115	COG1764	response to oxidative stress
BTZ13_RS06120	COG0584	glycerophosphoryl diester phosphodiesterase
BTZ13_RS06125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTZ13_RS06130	COG1956	GAF domain-containing protein
BTZ13_RS06135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BTZ13_RS06140	COG1104	cysteine desulfurase activity
BTZ13_RS06145	COG0301	tRNA thio-modification
BTZ13_RS06155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BTZ13_RS06160	COG0827	DNA restriction-modification system
BTZ13_RS06165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTZ13_RS06170	COG0589	response to stress
BTZ13_RS06175	COG0686	Belongs to the AlaDH PNT family
BTZ13_RS06180	COG0006	proline dipeptidase activity
BTZ13_RS06185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BTZ13_RS06195	COG4109	DRTGG domain
BTZ13_RS06200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BTZ13_RS06210	COG0281	malic enzyme
BTZ13_RS06215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTZ13_RS06220	COG0825	malonyl-CoA metabolic process
BTZ13_RS06225	COG0205	6-phosphofructokinase activity
BTZ13_RS06230	COG0469	pyruvate kinase activity
BTZ13_RS06235	COG1113	amino acid transport
BTZ13_RS06240	COG0372	Belongs to the citrate synthase family
BTZ13_RS06245	COG0538	isocitrate dehydrogenase activity
BTZ13_RS06250	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS06255	COG5002	protein histidine kinase activity
BTZ13_RS06260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTZ13_RS06260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTZ13_RS06265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTZ13_RS06270	COG0237	dephospho-CoA kinase activity
BTZ13_RS06280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTZ13_RS06285	COG3611	Membrane attachment protein
BTZ13_RS06290	COG1484	DNA-dependent DNA replication
BTZ13_RS06295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTZ13_RS06300	COG0833	amino acid
BTZ13_RS06305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTZ13_RS06310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTZ13_RS06315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTZ13_RS06320	COG4112	unkown
BTZ13_RS06330	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTZ13_RS06335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BTZ13_RS06340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTZ13_RS06345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTZ13_RS06350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTZ13_RS06355	COG0181	hydroxymethylbilane synthase activity
BTZ13_RS06370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTZ13_RS06375	COG3180	Ammonia monooxygenase
BTZ13_RS06380	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BTZ13_RS06385	COG2818	Glycosylase
BTZ13_RS06390	COG0525	valine-tRNA ligase activity
BTZ13_RS06395	COG0285	dihydrofolate synthase activity
BTZ13_RS06405	COG2003	Belongs to the UPF0758 family
BTZ13_RS06415	COG1792	Involved in formation and maintenance of cell shape
BTZ13_RS06425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTZ13_RS06430	COG2868	ribosomal protein
BTZ13_RS06435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTZ13_RS06440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTZ13_RS06445	COG4492	Belongs to the UPF0735 family
BTZ13_RS06450	COG0632	four-way junction helicase activity
BTZ13_RS06455	COG2255	four-way junction helicase activity
BTZ13_RS06460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTZ13_RS06465	COG0343	queuine tRNA-ribosyltransferase activity
BTZ13_RS06470	COG1862	Preprotein translocase
BTZ13_RS06475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTZ13_RS06475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTZ13_RS06480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTZ13_RS06480	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BTZ13_RS06485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTZ13_RS06495	COG1490	D-aminoacyl-tRNA deacylase activity
BTZ13_RS06500	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTZ13_RS06505	COG0124	histidyl-tRNA synthetase
BTZ13_RS06510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTZ13_RS06520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTZ13_RS06525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTZ13_RS06530	COG1959	2 iron, 2 sulfur cluster binding
BTZ13_RS06535	COG3237	CsbD-like
BTZ13_RS06540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTZ13_RS06545	COG1104	cysteine desulfurase activity
BTZ13_RS06550	COG0482	sulfurtransferase activity
BTZ13_RS06560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BTZ13_RS06565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTZ13_RS06570	COG4472	Bacterial protein of unknown function (DUF965)
BTZ13_RS06575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTZ13_RS06580	COG3906	Belongs to the UPF0473 family
BTZ13_RS06585	COG4122	O-methyltransferase activity
BTZ13_RS06590	COG0826	peptidase U32
BTZ13_RS06595	COG0826	peptidase U32
BTZ13_RS06600	COG0572	uridine kinase
BTZ13_RS06605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTZ13_RS06610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTZ13_RS06615	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BTZ13_RS06620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BTZ13_RS06625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTZ13_RS06630	COG1534	Rna-binding protein
BTZ13_RS06635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTZ13_RS06640	COG1713	HD superfamily hydrolase involved in NAD metabolism
BTZ13_RS06645	COG0799	negative regulation of ribosome biogenesis
BTZ13_RS06650	COG2226	methyltransferase
BTZ13_RS06655	COG1555	photosystem II stabilization
BTZ13_RS06655	COG1596	polysaccharide export
BTZ13_RS06660	COG2131	deaminase
BTZ13_RS06665	COG0658	competence protein
BTZ13_RS06665	COG2333	competence protein COMEC
BTZ13_RS06670	COG1466	dna polymerase III delta subunit
BTZ13_RS06675	COG0268	Binds directly to 16S ribosomal RNA
BTZ13_RS06680	COG0481	GTPase activity
BTZ13_RS06685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTZ13_RS06690	COG1420	regulation of RNA biosynthetic process
BTZ13_RS06695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTZ13_RS06700	COG0443	Heat shock 70 kDa protein
BTZ13_RS06705	COG0484	heat shock protein binding
BTZ13_RS06710	COG2264	protein methyltransferase activity
BTZ13_RS06715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTZ13_RS06720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTZ13_RS06735	COG4864	UPF0365 protein
BTZ13_RS06745	COG1702	phosphate starvation-inducible protein PhoH
BTZ13_RS06750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTZ13_RS06765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTZ13_RS06770	COG1381	Involved in DNA repair and RecF pathway recombination
BTZ13_RS06775	COG0423	glycine-tRNA ligase activity
BTZ13_RS06780	COG0517	IMP dehydrogenase activity
BTZ13_RS06785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTZ13_RS06795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTZ13_RS06800	COG2384	SAM-dependent methyltransferase
BTZ13_RS06805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTZ13_RS06810	COG0513	Belongs to the DEAD box helicase family
BTZ13_RS06815	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BTZ13_RS06820	COG1121	(ABC) transporter
BTZ13_RS06825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTZ13_RS06840	COG0768	penicillin binding
BTZ13_RS06850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTZ13_RS06860	COG4483	Protein conserved in bacteria
BTZ13_RS06865	COG1940	carbohydrate kinase activity
BTZ13_RS06870	COG0011	TIGRFAM Protein of
BTZ13_RS06875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTZ13_RS06880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTZ13_RS06885	COG1459	type II secretion system
BTZ13_RS06915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTZ13_RS06920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTZ13_RS06925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTZ13_RS06930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTZ13_RS06935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTZ13_RS06940	COG0095	Lipoate-protein ligase
BTZ13_RS06955	COG0006	proline dipeptidase activity
BTZ13_RS06960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTZ13_RS06965	COG0511	ligase activity, forming carbon-carbon bonds
BTZ13_RS06970	COG0439	Biotin carboxylase
BTZ13_RS06980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTZ13_RS06985	COG1570	exodeoxyribonuclease VII activity
BTZ13_RS06990	COG1722	exodeoxyribonuclease VII activity
BTZ13_RS07000	COG1438	arginine binding
BTZ13_RS07005	COG0497	DNA recombination
BTZ13_RS07010	COG0280	phosphate acetyltransferase
BTZ13_RS07015	COG3426	butyrate kinase activity
BTZ13_RS07020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTZ13_RS07025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BTZ13_RS07030	COG0022	dehydrogenase e1 component
BTZ13_RS07035	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTZ13_RS07045	COG4129	membrane
BTZ13_RS07050	COG2195	Cleaves the N-terminal amino acid of tripeptides
BTZ13_RS07055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BTZ13_RS07065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BTZ13_RS07070	COG1234	tRNA 3'-trailer cleavage
BTZ13_RS07075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BTZ13_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
BTZ13_RS07085	COG0667	Aldo Keto reductase
BTZ13_RS07090	COG0494	nUDIX hydrolase
BTZ13_RS07095	COG0735	belongs to the Fur family
BTZ13_RS07100	COG4974	Belongs to the 'phage' integrase family
BTZ13_RS07120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTZ13_RS07125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTZ13_RS07130	COG1187	pseudouridine synthase activity
BTZ13_RS07135	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS07150	COG1141	Ferredoxin
BTZ13_RS07160	COG0514	ATP-dependent DNA helicase (RecQ)
BTZ13_RS07165	COG1388	LysM domain
BTZ13_RS07165	COG1388	LysM domain
BTZ13_RS07170	COG0492	ferredoxin-NADP+ reductase activity
BTZ13_RS07180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTZ13_RS07185	COG0539	negative regulation of cytoplasmic translation
BTZ13_RS07190	COG1160	GTP binding
BTZ13_RS07195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTZ13_RS07210	COG2226	methyltransferase
BTZ13_RS07215	COG0142	geranyltranstransferase activity
BTZ13_RS07220	COG0105	UTP biosynthetic process
BTZ13_RS07225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTZ13_RS07230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTZ13_RS07235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTZ13_RS07240	COG0457	Tetratricopeptide repeat
BTZ13_RS07245	COG5582	Belongs to the UPF0302 family
BTZ13_RS07250	COG4347	Protein of unknown function (DUF1405)
BTZ13_RS07255	COG2738	Putative neutral zinc metallopeptidase
BTZ13_RS07260	COG1694	Mazg nucleotide pyrophosphohydrolase
BTZ13_RS07265	COG0438	transferase activity, transferring glycosyl groups
BTZ13_RS07270	COG0617	tRNA 3'-terminal CCA addition
BTZ13_RS07275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BTZ13_RS07275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BTZ13_RS07280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTZ13_RS07280	COG1199	ATP-dependent helicase activity
BTZ13_RS07285	COG0017	Asparaginyl-tRNA synthetase
BTZ13_RS07290	COG3935	DnaD domain protein
BTZ13_RS07295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTZ13_RS07305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTZ13_RS07305	COG4499	WXG100 protein secretion system (Wss), protein YukC
BTZ13_RS07310	COG3331	DNA recombination
BTZ13_RS07320	COG4474	Belongs to the UPF0398 family
BTZ13_RS07325	COG3599	regulation of cell shape
BTZ13_RS07335	COG0116	Belongs to the methyltransferase superfamily
BTZ13_RS07340	COG2962	Rard protein
BTZ13_RS07345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BTZ13_RS07350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTZ13_RS07355	COG0328	RNA-DNA hybrid ribonuclease activity
BTZ13_RS07360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTZ13_RS07370	COG1413	lyase activity
BTZ13_RS07400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTZ13_RS07405	COG2190	(PTS) system
BTZ13_RS07410	COG4479	Belongs to the UPF0346 family
BTZ13_RS07415	COG0793	Belongs to the peptidase S41A family
BTZ13_RS07425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTZ13_RS07430	COG0671	phosphoesterase, PA-phosphatase related
BTZ13_RS07435	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS07440	COG5002	protein histidine kinase activity
BTZ13_RS07445	COG0567	Dehydrogenase, E1 component
BTZ13_RS07470	COG0714	Associated with various cellular activities
BTZ13_RS07475	COG4548	von Willebrand factor, type A
BTZ13_RS07480	COG1114	Component of the transport system for branched-chain amino acids
BTZ13_RS07485	COG1597	lipid kinase activity
BTZ13_RS07490	COG3853	Toxic anion resistance protein (TelA)
BTZ13_RS07525	COG1473	amidohydrolase
BTZ13_RS07530	COG2171	N-acyltransferase activity
BTZ13_RS07535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BTZ13_RS07540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTZ13_RS07545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTZ13_RS07550	COG0527	aspartate kinase activity
BTZ13_RS07555	COG0488	(ABC) transporter
BTZ13_RS07560	COG2996	Protein conserved in bacteria
BTZ13_RS07565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BTZ13_RS07570	COG0573	inorganic phosphate transmembrane transporter activity
BTZ13_RS07575	COG0581	inorganic phosphate transmembrane transporter activity
BTZ13_RS07580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTZ13_RS07585	COG0704	Plays a role in the regulation of phosphate uptake
BTZ13_RS07590	COG1164	Oligoendopeptidase f
BTZ13_RS07600	COG0747	negative chemotaxis
BTZ13_RS07635	COG2348	transferase activity, transferring amino-acyl groups
BTZ13_RS07640	COG0159	tryptophan synthase activity
BTZ13_RS07650	COG0135	phosphoribosylanthranilate isomerase activity
BTZ13_RS07655	COG0134	indole-3-glycerol-phosphate synthase activity
BTZ13_RS07660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTZ13_RS07670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BTZ13_RS07675	COG1363	Peptidase, m42
BTZ13_RS07680	COG0287	Prephenate dehydrogenase
BTZ13_RS07685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTZ13_RS07705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BTZ13_RS07720	COG0628	permease
BTZ13_RS07725	COG1263	PTS System
BTZ13_RS07725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTZ13_RS07725	COG2190	(PTS) system
BTZ13_RS07730	COG1263	PTS System
BTZ13_RS07730	COG2190	(PTS) system
BTZ13_RS07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTZ13_RS07735	COG3711	transcriptional antiterminator
BTZ13_RS07740	COG1115	amino acid carrier protein
BTZ13_RS07745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BTZ13_RS07755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTZ13_RS07760	COG4841	protein insertion into membrane
BTZ13_RS07765	COG0824	Thioesterase
BTZ13_RS07770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTZ13_RS07775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTZ13_RS07780	COG1970	mechanosensitive ion channel activity
BTZ13_RS07785	COG0419	ATPase involved in DNA repair
BTZ13_RS07790	COG0420	3'-5' exonuclease activity
BTZ13_RS07795	COG4846	Membrane protein involved in cytochrome C biogenesis
BTZ13_RS07800	COG3763	UPF0154 protein
BTZ13_RS07805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTZ13_RS07810	COG4224	UPF0291 protein
BTZ13_RS07820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTZ13_RS07825	COG2340	Cysteine-rich secretory protein family
BTZ13_RS07830	COG0516	GMP reductase activity
BTZ13_RS07835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTZ13_RS07845	COG0833	amino acid
BTZ13_RS07855	COG0561	phosphatase activity
BTZ13_RS07860	COG0083	homoserine kinase activity
BTZ13_RS07865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BTZ13_RS07870	COG0460	homoserine dehydrogenase
BTZ13_RS07875	COG0527	aspartate kinase activity
BTZ13_RS07900	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BTZ13_RS07905	COG1525	nuclease
BTZ13_RS07915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTZ13_RS07925	COG0789	Transcriptional regulator
BTZ13_RS07940	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BTZ13_RS07945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTZ13_RS07955	COG1923	regulation of RNA biosynthetic process
BTZ13_RS07960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTZ13_RS07965	COG2267	carboxylic ester hydrolase activity
BTZ13_RS07970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTZ13_RS07975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BTZ13_RS07980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BTZ13_RS07990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTZ13_RS07995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTZ13_RS08000	COG0584	glycerophosphoryl diester phosphodiesterase
BTZ13_RS08010	COG4550	Control of competence regulator ComK, YlbF/YmcA
BTZ13_RS08015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTZ13_RS08030	COG1013	pyruvate-flavodoxin oxidoreductase activity
BTZ13_RS08035	COG0674	pyruvate-flavodoxin oxidoreductase activity
BTZ13_RS08035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BTZ13_RS08040	COG1692	metallophosphoesterase
BTZ13_RS08050	COG0583	DNA-binding transcription factor activity
BTZ13_RS08060	COG1418	mRNA catabolic process
BTZ13_RS08065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTZ13_RS08070	COG1546	Belongs to the CinA family
BTZ13_RS08070	COG1058	Belongs to the CinA family
BTZ13_RS08090	COG0300	oxidoreductase activity
BTZ13_RS08095	COG0612	Peptidase, M16
BTZ13_RS08100	COG0612	Peptidase, M16
BTZ13_RS08105	COG2188	Transcriptional regulator
BTZ13_RS08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BTZ13_RS08120	COG1185	polyribonucleotide nucleotidyltransferase activity
BTZ13_RS08125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTZ13_RS08130	COG0196	riboflavin kinase activity
BTZ13_RS08135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTZ13_RS08140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTZ13_RS08160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTZ13_RS08165	COG1358	cellular component organization or biogenesis
BTZ13_RS08170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BTZ13_RS08175	COG0195	Participates in both transcription termination and antitermination
BTZ13_RS08180	COG0779	Required for maturation of 30S ribosomal subunits
BTZ13_RS08185	COG2176	DNA-directed DNA polymerase activity
BTZ13_RS08195	COG0442	prolyl-tRNA aminoacylation
BTZ13_RS08205	COG4589	Belongs to the CDS family
BTZ13_RS08215	COG0233	cytoplasmic translational termination
BTZ13_RS08220	COG0528	UMP kinase activity
BTZ13_RS08225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTZ13_RS08230	COG0052	Belongs to the universal ribosomal protein uS2 family
BTZ13_RS08235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BTZ13_RS08240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTZ13_RS08245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BTZ13_RS08250	COG4974	Belongs to the 'phage' integrase family
BTZ13_RS08255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BTZ13_RS08260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTZ13_RS08270	COG0045	succinate-CoA ligase (ADP-forming) activity
BTZ13_RS08275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTZ13_RS08295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BTZ13_RS08300	COG4485	Bacterial membrane protein, YfhO
BTZ13_RS08310	COG4932	domain protein
BTZ13_RS08310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BTZ13_RS08310	COG3583	domain protein
BTZ13_RS08315	COG0335	large ribosomal subunit rRNA binding
BTZ13_RS08320	COG0336	Belongs to the RNA methyltransferase TrmD family
BTZ13_RS08325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTZ13_RS08330	COG0228	four-way junction DNA binding
BTZ13_RS08340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTZ13_RS08345	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BTZ13_RS08350	COG0552	protein localization to endoplasmic reticulum
BTZ13_RS08355	COG1196	nuclear chromosome segregation
BTZ13_RS08360	COG0571	ribonuclease III activity
BTZ13_RS08365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTZ13_RS08380	COG0416	fatty acid biosynthetic process
BTZ13_RS08385	COG1349	DNA-binding transcription factor activity
BTZ13_RS08390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTZ13_RS08395	COG1760	l-serine dehydratase
BTZ13_RS08400	COG1760	l-serine dehydratase
BTZ13_RS08405	COG1461	Dihydroxyacetone kinase
BTZ13_RS08410	COG1302	Protein conserved in bacteria
BTZ13_RS08415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTZ13_RS08430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTZ13_RS08435	COG1162	GTPase activity
BTZ13_RS08445	COG0631	protein serine/threonine phosphatase activity
BTZ13_RS08450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTZ13_RS08455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTZ13_RS08455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTZ13_RS08460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTZ13_RS08485	COG2910	NAD(P)H-binding
BTZ13_RS08490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTZ13_RS08495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTZ13_RS08505	COG1758	RNA polymerase activity
BTZ13_RS08510	COG0194	GDP metabolic process
BTZ13_RS08540	COG0284	orotidine-5'-phosphate decarboxylase activity
BTZ13_RS08545	COG0167	dihydroorotate dehydrogenase activity
BTZ13_RS08550	COG0543	2 iron, 2 sulfur cluster binding
BTZ13_RS08555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTZ13_RS08560	COG0505	Belongs to the CarA family
BTZ13_RS08570	COG0540	Belongs to the ATCase OTCase family
BTZ13_RS08575	COG2233	PERMEase
BTZ13_RS08580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BTZ13_RS08585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BTZ13_RS08600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BTZ13_RS08605	COG0564	pseudouridine synthase activity
BTZ13_RS08610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTZ13_RS08615	COG3942	CHAP domain
BTZ13_RS08620	COG2514	catechol 2,3-dioxygenase activity
BTZ13_RS08625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTZ13_RS08630	COG3599	regulation of cell shape
BTZ13_RS08640	COG0762	integral membrane protein
BTZ13_RS08645	COG1799	cell septum assembly
BTZ13_RS08650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTZ13_RS08655	COG1496	oxidoreductase activity
BTZ13_RS08665	COG0849	cell division
BTZ13_RS08670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTZ13_RS08675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTZ13_RS08680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTZ13_RS08685	COG0768	penicillin binding
BTZ13_RS08690	COG4839	cell division protein FtsL
BTZ13_RS08695	COG0275	rRNA processing
BTZ13_RS08700	COG2001	Belongs to the MraZ family
BTZ13_RS08705	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BTZ13_RS08710	COG0454	-acetyltransferase
BTZ13_RS08715	COG1011	Hydrolase
BTZ13_RS08760	COG1045	serine acetyltransferase
BTZ13_RS08785	COG2153	protein acetylation
BTZ13_RS08810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTZ13_RS08815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BTZ13_RS08830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTZ13_RS08835	COG1053	succinate dehydrogenase
BTZ13_RS08840	COG2009	succinate dehydrogenase
BTZ13_RS08845	COG0322	excinuclease ABC activity
BTZ13_RS08850	COG3118	belongs to the thioredoxin family
BTZ13_RS08855	COG1193	negative regulation of DNA recombination
BTZ13_RS08860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BTZ13_RS08860	COG1796	DNA polymerase
BTZ13_RS08875	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTZ13_RS08880	COG0072	phenylalanine-tRNA ligase activity
BTZ13_RS08880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTZ13_RS08885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTZ13_RS08890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTZ13_RS08895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTZ13_RS08910	COG1323	Belongs to the UPF0348 family
BTZ13_RS08920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTZ13_RS08925	COG0742	ribosomal rna small subunit methyltransferase
BTZ13_RS08935	COG4471	UPF0298 protein
BTZ13_RS08940	COG0584	glycerophosphoryl diester phosphodiesterase
BTZ13_RS08945	COG3679	Belongs to the UPF0342 family
BTZ13_RS08960	COG0109	protoheme IX farnesyltransferase activity
BTZ13_RS08965	COG1612	heme a metabolic process
BTZ13_RS08975	COG0772	Belongs to the SEDS family
BTZ13_RS08980	COG4838	Belongs to the UPF0358 family
BTZ13_RS08985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTZ13_RS08995	COG1217	gtp-binding protein TYPA
BTZ13_RS09005	COG0483	inositol monophosphate 1-phosphatase activity
BTZ13_RS09010	COG4493	Belongs to the UPF0637 family
BTZ13_RS09015	COG1914	H( )-stimulated, divalent metal cation uptake system
BTZ13_RS09035	COG1177	transmembrane transport
BTZ13_RS09040	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTZ13_RS09045	COG3842	ATPase activity
BTZ13_RS09055	COG4476	Belongs to the UPF0223 family
BTZ13_RS09070	COG0022	dehydrogenase e1 component
BTZ13_RS09085	COG0242	peptide deformylase activity
BTZ13_RS09095	COG5503	Protein of unknown function (DUF1447)
BTZ13_RS09105	COG0569	domain protein
BTZ13_RS09110	COG1294	oxidase, subunit
BTZ13_RS09115	COG1271	oxidase subunit
BTZ13_RS09125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTZ13_RS09140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BTZ13_RS09155	COG1122	ATPase activity
BTZ13_RS09160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTZ13_RS09170	COG0151	Belongs to the GarS family
BTZ13_RS09175	COG0138	bifunctional purine biosynthesis protein purh
BTZ13_RS09180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BTZ13_RS09185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTZ13_RS09190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BTZ13_RS09195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTZ13_RS09200	COG0047	phosphoribosylformylglycinamidine synthase activity
BTZ13_RS09210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTZ13_RS09215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTZ13_RS09220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTZ13_RS09225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTZ13_RS09230	COG1363	Peptidase, m42
BTZ13_RS09240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTZ13_RS09240	COG1017	nitric oxide dioxygenase activity
BTZ13_RS09250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTZ13_RS09260	COG1845	cytochrome c oxidase, subunit III
BTZ13_RS09265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTZ13_RS09275	COG1349	DNA-binding transcription factor activity
BTZ13_RS09285	COG0698	ribose 5-phosphate isomerase
BTZ13_RS09290	COG1105	Belongs to the carbohydrate kinase PfkB family
BTZ13_RS09300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BTZ13_RS09305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTZ13_RS09310	COG2723	6-phospho-beta-galactosidase activity
BTZ13_RS09315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTZ13_RS09315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTZ13_RS09320	COG5632	N-Acetylmuramoyl-L-alanine amidase
BTZ13_RS09320	COG1388	LysM domain
BTZ13_RS09560	COG1484	DNA-dependent DNA replication
BTZ13_RS09605	COG3561	AntA/AntB antirepressor
BTZ13_RS09635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTZ13_RS09635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTZ13_RS09640	COG1447	Phosphotransferase system cellobiose-specific component IIA
BTZ13_RS09655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTZ13_RS09660	COG1316	TRANSCRIPTIONal
BTZ13_RS09685	COG3594	Acyltransferase
BTZ13_RS09690	COG0436	Aminotransferase
BTZ13_RS09695	COG1846	Transcriptional regulator
BTZ13_RS09700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTZ13_RS09710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BTZ13_RS09715	COG1169	isochorismate synthase
BTZ13_RS09720	COG1575	Belongs to the MenA family. Type 1 subfamily
BTZ13_RS09730	COG2314	TM2 domain
BTZ13_RS09745	COG4873	Protein conserved in bacteria
BTZ13_RS09775	COG3177	Filamentation induced by cAMP protein fic
BTZ13_RS09785	COG2267	carboxylic ester hydrolase activity
BTZ13_RS09795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTZ13_RS09805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTZ13_RS09810	COG0131	Imidazoleglycerol-phosphate dehydratase
BTZ13_RS09820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTZ13_RS09825	COG0107	imidazoleglycerol-phosphate synthase activity
BTZ13_RS09835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTZ13_RS09845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTZ13_RS09850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTZ13_RS09855	COG0861	Integral membrane protein TerC family
BTZ13_RS09860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTZ13_RS09870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTZ13_RS09875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTZ13_RS09880	COG2814	Major facilitator Superfamily
BTZ13_RS09890	COG2382	esterase
BTZ13_RS09895	COG1115	amino acid carrier protein
BTZ13_RS09900	COG0628	permease
BTZ13_RS09905	COG2814	Major facilitator Superfamily
BTZ13_RS09915	COG0569	domain protein
BTZ13_RS09915	COG0475	glutathione-regulated potassium exporter activity
BTZ13_RS09920	COG2239	Acts as a magnesium transporter
BTZ13_RS09925	COG0564	pseudouridine synthase activity
BTZ13_RS09930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTZ13_RS09935	COG2357	RelA SpoT domain protein
BTZ13_RS09945	COG4116	CYTH
BTZ13_RS09950	COG2346	COG2346, Truncated hemoglobins
BTZ13_RS09955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BTZ13_RS09970	COG1164	Oligoendopeptidase f
BTZ13_RS09975	COG4862	establishment of competence for transformation
BTZ13_RS09980	COG1393	Belongs to the ArsC family
BTZ13_RS09995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTZ13_RS10000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTZ13_RS10005	COG4166	transmembrane transport
BTZ13_RS10010	COG4608	Belongs to the ABC transporter superfamily
BTZ13_RS10015	COG0444	Belongs to the ABC transporter superfamily
BTZ13_RS10020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTZ13_RS10025	COG0601	transmembrane transport
BTZ13_RS10045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTZ13_RS10055	COG0542	response to heat
BTZ13_RS10065	COG2151	metal-sulfur cluster biosynthetic enzyme
BTZ13_RS10070	COG0561	phosphatase activity
BTZ13_RS10075	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTZ13_RS10085	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTZ13_RS10090	COG1074	ATP-dependent DNA helicase activity
BTZ13_RS10095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BTZ13_RS10110	COG0398	Pfam SNARE associated Golgi protein
BTZ13_RS10120	COG0137	argininosuccinate synthase activity
BTZ13_RS10125	COG0165	Argininosuccinate lyase
BTZ13_RS10140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTZ13_RS10145	COG1012	belongs to the aldehyde dehydrogenase family
BTZ13_RS10150	COG1902	pentaerythritol trinitrate reductase activity
BTZ13_RS10160	COG1098	S1 RNA binding domain
BTZ13_RS10165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BTZ13_RS10175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTZ13_RS10185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTZ13_RS10185	COG2111	Na H antiporter
BTZ13_RS10190	COG2111	Na H antiporter
BTZ13_RS10195	COG1006	Multisubunit Na H antiporter MnhC subunit
BTZ13_RS10200	COG0651	ATP synthesis coupled electron transport
BTZ13_RS10205	COG1863	multisubunit Na H antiporter MnhE subunit
BTZ13_RS10210	COG2212	antiporter activity
BTZ13_RS10225	COG2050	protein possibly involved in aromatic compounds catabolism
BTZ13_RS10230	COG2056	Na+-H+ antiporter family
BTZ13_RS10235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTZ13_RS10240	COG1252	NADH dehydrogenase
BTZ13_RS10245	COG0316	Belongs to the HesB IscA family
BTZ13_RS10250	COG4844	belongs to the
BTZ13_RS10255	COG1252	NADH dehydrogenase
BTZ13_RS10265	COG4837	Protein of unknown function (DUF1462)
BTZ13_RS10270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BTZ13_RS10275	COG0789	Transcriptional regulator
BTZ13_RS10285	COG2217	Heavy metal translocating P-type atpase
BTZ13_RS10290	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BTZ13_RS10295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTZ13_RS10300	COG1696	Membrane protein involved in D-alanine export
BTZ13_RS10305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTZ13_RS10315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTZ13_RS10320	COG0647	UMP catabolic process
BTZ13_RS10325	COG2445	Protein of unknown function DUF86
BTZ13_RS10335	COG4470	Protein conserved in bacteria
BTZ13_RS10340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTZ13_RS10345	COG0737	Belongs to the 5'-nucleotidase family
BTZ13_RS10350	COG0730	response to heat
BTZ13_RS10355	COG1801	Protein of unknown function DUF72
BTZ13_RS10365	COG4536	flavin adenine dinucleotide binding
BTZ13_RS10375	COG0464	growth
BTZ13_RS10385	COG0719	Fe-S assembly protein
BTZ13_RS10390	COG0822	iron-sulfur transferase activity
BTZ13_RS10395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BTZ13_RS10400	COG0719	Fe-S assembly protein
BTZ13_RS10405	COG0396	ATPase activity
BTZ13_RS10410	COG1464	Belongs to the NlpA lipoprotein family
BTZ13_RS10415	COG2011	ABC-type metal ion transport system permease component
BTZ13_RS10420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTZ13_RS10425	COG3118	belongs to the thioredoxin family
BTZ13_RS10430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BTZ13_RS10435	COG0509	glycine decarboxylation via glycine cleavage system
BTZ13_RS10440	COG1393	Belongs to the ArsC family
BTZ13_RS10445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTZ13_RS10455	COG0710	3-dehydroquinate dehydratase activity
BTZ13_RS10485	COG1704	LemA family
BTZ13_RS10490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTZ13_RS10505	COG1278	Cold shock
BTZ13_RS10520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTZ13_RS10530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTZ13_RS10535	COG0557	exoribonuclease II activity
BTZ13_RS10540	COG1647	Serine aminopeptidase, S33
BTZ13_RS10545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTZ13_RS10555	COG0148	phosphopyruvate hydratase activity
BTZ13_RS10570	COG0126	phosphoglycerate kinase activity
BTZ13_RS10575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTZ13_RS10600	COG0740	serine-type endopeptidase activity
BTZ13_RS10610	COG1114	Component of the transport system for branched-chain amino acids
BTZ13_RS10615	COG2814	Major facilitator Superfamily
BTZ13_RS10620	COG1481	regulation of sporulation
BTZ13_RS10625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BTZ13_RS10630	COG1660	Displays ATPase and GTPase activities
BTZ13_RS10645	COG0110	maltose O-acetyltransferase activity
BTZ13_RS10650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTZ13_RS10655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTZ13_RS10680	COG3942	CHAP domain
BTZ13_RS10685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BTZ13_RS10690	COG0653	protein targeting
BTZ13_RS10695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTZ13_RS10705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BTZ13_RS10715	COG1739	Uncharacterized protein family UPF0029
BTZ13_RS10720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTZ13_RS10725	COG2199	diguanylate cyclase activity
BTZ13_RS10740	COG2195	Cleaves the N-terminal amino acid of tripeptides
BTZ13_RS10745	COG1929	Belongs to the glycerate kinase type-1 family
BTZ13_RS10765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BTZ13_RS10780	COG4607	ABC-type enterochelin transport system periplasmic component
BTZ13_RS10785	COG4604	ABC transporter, ATP-binding protein
BTZ13_RS10790	COG4605	iron ion homeostasis
BTZ13_RS10795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS10800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTZ13_RS10805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTZ13_RS10810	COG1780	Probably involved in ribonucleotide reductase function
BTZ13_RS10815	COG0697	spore germination
BTZ13_RS10820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTZ13_RS10825	COG3104	oligopeptide transport
BTZ13_RS10830	COG3104	oligopeptide transport
BTZ13_RS10835	COG2226	methyltransferase
BTZ13_RS10845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTZ13_RS10850	COG1174	glycine betaine transport
BTZ13_RS10860	COG0514	ATP-dependent DNA helicase (RecQ)
BTZ13_RS10865	COG0488	(ABC) transporter
BTZ13_RS10870	COG1368	sulfuric ester hydrolase activity
BTZ13_RS10880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTZ13_RS10890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTZ13_RS10895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BTZ13_RS10900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTZ13_RS10900	COG0512	Glutamine amidotransferase of anthranilate synthase
BTZ13_RS10905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTZ13_RS10910	COG0720	synthase
BTZ13_RS10915	COG0602	queuosine metabolic process
BTZ13_RS10930	COG0656	L-ascorbic acid biosynthetic process
BTZ13_RS10935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BTZ13_RS10960	COG1253	flavin adenine dinucleotide binding
BTZ13_RS10965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTZ13_RS10965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTZ13_RS10965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTZ13_RS10970	COG1105	Belongs to the carbohydrate kinase PfkB family
BTZ13_RS10975	COG1349	DNA-binding transcription factor activity
BTZ13_RS10980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTZ13_RS11015	COG0471	metal ion transport
BTZ13_RS11020	COG0039	L-malate dehydrogenase activity
BTZ13_RS11025	COG0586	Pfam SNARE associated Golgi protein
BTZ13_RS11035	COG4989	oxidoreductase activity
BTZ13_RS11040	COG0523	cobalamin synthesis protein
BTZ13_RS11050	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTZ13_RS11055	COG4988	ABC transporter
BTZ13_RS11060	COG1968	undecaprenyl-diphosphatase activity
BTZ13_RS11070	COG1671	Belongs to the UPF0178 family
BTZ13_RS11100	COG2839	Protein conserved in bacteria
BTZ13_RS11105	COG2814	Major facilitator Superfamily
BTZ13_RS11110	COG0583	DNA-binding transcription factor activity
BTZ13_RS11125	COG0217	transcriptional regulatory protein
BTZ13_RS11145	COG1388	LysM domain
BTZ13_RS11145	COG3942	CHAP domain
BTZ13_RS11150	COG1733	regulation of RNA biosynthetic process
BTZ13_RS11155	COG2814	Major facilitator Superfamily
BTZ13_RS11160	COG0656	L-ascorbic acid biosynthetic process
BTZ13_RS11165	COG0306	phosphate transporter
BTZ13_RS11170	COG1392	Phosphate transport regulator
BTZ13_RS11175	COG0577	efflux transmembrane transporter activity
BTZ13_RS11180	COG1136	(ABC) transporter
BTZ13_RS11185	COG2205	protein histidine kinase activity
BTZ13_RS11190	COG0745	RESPONSE REGULATOR receiver
BTZ13_RS11200	COG0657	acetylesterase activity
BTZ13_RS11205	COG3949	Membrane
BTZ13_RS11215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS11225	COG1120	ATPase activity
BTZ13_RS11230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTZ13_RS11235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BTZ13_RS11240	COG1132	(ABC) transporter
BTZ13_RS11245	COG1686	Belongs to the peptidase S11 family
BTZ13_RS11250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTZ13_RS11260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BTZ13_RS11265	COG1682	transport, permease protein
BTZ13_RS11275	COG5609	conserved protein (DUF2294)
BTZ13_RS11280	COG3949	Membrane
BTZ13_RS11295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTZ13_RS11305	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BTZ13_RS11310	COG0110	maltose O-acetyltransferase activity
BTZ13_RS11320	COG1247	-acetyltransferase
BTZ13_RS11330	COG1121	(ABC) transporter
BTZ13_RS11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTZ13_RS11340	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTZ13_RS11345	COG0025	NhaP-type Na H and K H
BTZ13_RS11395	COG0546	phosphoglycolate phosphatase activity
BTZ13_RS11400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTZ13_RS11405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTZ13_RS11410	COG0018	arginyl-trna synthetase
BTZ13_RS11420	COG1473	amidohydrolase
BTZ13_RS11450	COG1078	dGTPase activity
BTZ13_RS11455	COG0519	Catalyzes the synthesis of GMP from XMP
BTZ13_RS11470	COG4844	belongs to the
BTZ13_RS11490	COG0095	Lipoate-protein ligase
BTZ13_RS11495	COG0280	phosphate acetyltransferase
BTZ13_RS11500	COG3253	May function as heme-dependent peroxidase
BTZ13_RS11520	COG0586	Pfam SNARE associated Golgi protein
BTZ13_RS11525	COG0531	amino acid
BTZ13_RS11530	COG2363	Small membrane protein
BTZ13_RS11540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTZ13_RS11550	COG0477	Major facilitator Superfamily
BTZ13_RS11555	COG1469	GTP cyclohydrolase I activity
BTZ13_RS11560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BTZ13_RS11565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BTZ13_RS11570	COG0363	glucosamine-6-phosphate deaminase activity
BTZ13_RS11575	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BTZ13_RS11585	COG0431	NADPH-dependent FMN reductase
BTZ13_RS11590	COG0561	phosphatase activity
BTZ13_RS11600	COG1428	Deoxynucleoside kinase
BTZ13_RS11605	COG1428	Deoxynucleoside kinase
BTZ13_RS11610	COG0561	phosphatase activity
BTZ13_RS11620	COG0546	phosphoglycolate phosphatase activity
BTZ13_RS11625	COG2832	Protein of unknown function (DUF454)
BTZ13_RS11630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTZ13_RS11650	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BTZ13_RS11660	COG1473	amidohydrolase
BTZ13_RS11670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTZ13_RS11675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTZ13_RS11680	COG0049	tRNA binding
BTZ13_RS11685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTZ13_RS11700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTZ13_RS11705	COG0085	RNA polymerase activity
BTZ13_RS11710	COG2813	Specifically methylates the guanine in position
BTZ13_RS11720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTZ13_RS11725	COG0081	regulation of translation
BTZ13_RS11730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTZ13_RS11735	COG0250	Participates in transcription elongation, termination and antitermination
BTZ13_RS11740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTZ13_RS11745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTZ13_RS11760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTZ13_RS11765	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BTZ13_RS11770	COG0215	cysteine-tRNA ligase activity
BTZ13_RS11775	COG1045	serine acetyltransferase
BTZ13_RS11780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTZ13_RS11785	COG4956	integral membrane protein (PIN domain superfamily)
BTZ13_RS11790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BTZ13_RS11795	COG0542	response to heat
BTZ13_RS11800	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BTZ13_RS11805	COG3880	PFAM UvrB UvrC protein
BTZ13_RS11815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BTZ13_RS11830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BTZ13_RS11835	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BTZ13_RS11840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTZ13_RS11850	COG2814	Major facilitator Superfamily
BTZ13_RS11920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTZ13_RS11925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTZ13_RS11930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BTZ13_RS11935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BTZ13_RS11950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTZ13_RS11955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTZ13_RS11970	COG1098	S1 RNA binding domain
BTZ13_RS11980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BTZ13_RS11985	COG3956	TIGRFAM MazG family protein
BTZ13_RS11990	COG2244	polysaccharide biosynthetic process
BTZ13_RS11995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTZ13_RS12000	COG0193	aminoacyl-tRNA hydrolase activity
BTZ13_RS12005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTZ13_RS12010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTZ13_RS12015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTZ13_RS12020	COG2088	sporulation resulting in formation of a cellular spore
BTZ13_RS12025	COG0251	oxidation-reduction process
BTZ13_RS12030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTZ13_RS12040	COG4466	Protein conserved in bacteria
BTZ13_RS12045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTZ13_RS12050	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BTZ13_RS12055	COG0084	hydrolase, TatD family'
BTZ13_RS12060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTZ13_RS12060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTZ13_RS12100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BTZ13_RS12105	COG2827	Endonuclease containing a URI domain
BTZ13_RS12110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BTZ13_RS12115	COG4467	Involved in initiation control of chromosome replication
BTZ13_RS12120	COG1774	PSP1 C-terminal conserved region
BTZ13_RS12125	COG0470	DNA polymerase III
BTZ13_RS12130	COG3870	Protein conserved in bacteria
BTZ13_RS12135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTZ13_RS12140	COG1982	Orn Lys Arg decarboxylase major
BTZ13_RS12160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTZ13_RS12165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTZ13_RS12170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTZ13_RS12185	COG2814	Major facilitator Superfamily
BTZ13_RS12205	COG0640	Transcriptional regulator
BTZ13_RS12210	COG2188	Transcriptional regulator
BTZ13_RS12215	COG0366	Alpha amylase catalytic
BTZ13_RS12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTZ13_RS12220	COG1263	PTS System
BTZ13_RS12225	COG0346	lactoylglutathione lyase activity
BTZ13_RS12235	COG0493	'glutamate synthase
BTZ13_RS12240	COG0070	glutamate synthase
BTZ13_RS12240	COG0069	glutamate synthase activity
BTZ13_RS12240	COG0067	glutamate synthase
BTZ13_RS12245	COG0583	DNA-binding transcription factor activity
BTZ13_RS12275	COG4841	protein insertion into membrane
BTZ13_RS12280	COG0494	nUDIX hydrolase
BTZ13_RS12285	COG4841	protein insertion into membrane
BTZ13_RS12295	COG0737	Belongs to the 5'-nucleotidase family
BTZ13_RS12310	COG3246	L-lysine catabolic process to acetate
BTZ13_RS12315	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTZ13_RS12325	COG1279	arginine transmembrane transporter activity
BTZ13_RS12330	COG0626	cystathionine gamma-synthase activity
BTZ13_RS12335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTZ13_RS12340	COG0733	neurotransmitter:sodium symporter activity
BTZ13_RS12350	COG1647	Serine aminopeptidase, S33
BTZ13_RS12355	COG1755	Isoprenylcysteine carboxyl methyltransferase
BTZ13_RS12390	COG0346	lactoylglutathione lyase activity
BTZ13_RS12405	COG1695	Transcriptional regulator
BTZ13_RS12410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTZ13_RS12440	COG0529	Catalyzes the synthesis of activated sulfate
BTZ13_RS12445	COG2046	Belongs to the sulfate adenylyltransferase family
BTZ13_RS12450	COG0730	response to heat
BTZ13_RS12455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTZ13_RS12460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BTZ13_RS12465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BTZ13_RS12470	COG0175	sulfate reduction
BTZ13_RS12485	COG1216	Glycosyl transferase, family 2
BTZ13_RS12495	COG1131	(ABC) transporter
BTZ13_RS12505	COG0535	radical SAM domain protein
BTZ13_RS12535	COG1396	sequence-specific DNA binding
BTZ13_RS12545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTZ13_RS12545	COG0519	Catalyzes the synthesis of GMP from XMP
BTZ13_RS12550	COG0516	GMP reductase activity
BTZ13_RS12550	COG0517	IMP dehydrogenase activity
BTZ13_RS12555	COG2233	PERMEase
BTZ13_RS12560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTZ13_RS12580	COG1823	symporter activity
BTZ13_RS12585	COG0778	Nitroreductase
BTZ13_RS12595	COG0450	alkyl hydroperoxide reductase
BTZ13_RS12600	COG3634	alkyl hydroperoxide reductase activity
BTZ13_RS12620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTZ13_RS12625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTZ13_RS12645	COG4509	Sortase family
BTZ13_RS12680	COG1129	ABC transporter
BTZ13_RS12700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTZ13_RS12710	COG0360	Binds together with S18 to 16S ribosomal RNA
BTZ13_RS12730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTZ13_RS12750	COG0012	GTP binding
BTZ13_RS12755	COG4481	Protein conserved in bacteria
BTZ13_RS12760	COG0668	transmembrane transport
BTZ13_RS12765	COG1475	DNA binding
BTZ13_RS12775	COG0626	cystathionine gamma-synthase activity
BTZ13_RS12780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTZ13_RS12780	COG0646	methionine synthase
BTZ13_RS12785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTZ13_RS12795	COG0436	Aminotransferase
BTZ13_RS12810	COG1475	DNA binding
BTZ13_RS12815	COG0357	Ribosomal RNA small subunit methyltransferase G
BTZ13_RS12820	COG0445	tRNA wobble uridine modification
BTZ13_RS12825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTZ13_RS12830	COG0594	ribonuclease P activity
BTZ13_RS12860	COG0187	DNA topoisomerase II activity
BTZ13_RS12930	COG0305	Participates in initiation and elongation during chromosome replication