locus-tag	class	description
MUA22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MUA22_RS00010	COG0592	DNA-directed DNA polymerase activity
MUA22_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MUA22_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MUA22_RS00020	COG2501	S4 domain
MUA22_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MUA22_RS00030	COG0187	DNA topoisomerase II activity
MUA22_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MUA22_RS00045	COG2986	histidine ammonia-lyase
MUA22_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MUA22_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MUA22_RS00070	COG4241	membrane
MUA22_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MUA22_RS00080	COG0359	binds to the 23S rRNA
MUA22_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
MUA22_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MUA22_RS00100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA22_RS00120	COG0745	RESPONSE REGULATOR receiver
MUA22_RS00125	COG5002	protein histidine kinase activity
MUA22_RS00130	COG4863	YycH protein
MUA22_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MUA22_RS00150	COG1196	nuclear chromosome segregation
MUA22_RS00160	COG0693	protein deglycase activity
MUA22_RS00190	COG3832	glyoxalase III activity
MUA22_RS00205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MUA22_RS00250	COG0747	negative chemotaxis
MUA22_RS00260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MUA22_RS00265	COG4172	Belongs to the ABC transporter superfamily
MUA22_RS00270	COG1124	(ABC) transporter
MUA22_RS00285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MUA22_RS00305	COG0659	secondary active sulfate transmembrane transporter activity
MUA22_RS00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MUA22_RS00325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MUA22_RS00345	COG4975	Glucose uptake
MUA22_RS00365	COG0202	RNA polymerase activity
MUA22_RS00380	COG0513	Belongs to the DEAD box helicase family
MUA22_RS00400	COG0531	amino acid
MUA22_RS00410	COG2357	RelA SpoT domain protein
MUA22_RS00415	COG2217	Heavy metal translocating P-type atpase
MUA22_RS00435	COG4409	exo-alpha-(2->6)-sialidase activity
MUA22_RS00440	COG4409	exo-alpha-(2->6)-sialidase activity
MUA22_RS00470	COG2188	Transcriptional regulator
MUA22_RS00480	COG2723	6-phospho-beta-galactosidase activity
MUA22_RS00500	COG0454	-acetyltransferase
MUA22_RS00510	COG0201	protein transport
MUA22_RS00520	COG1073	alpha beta
MUA22_RS00530	COG0653	protein targeting
MUA22_RS00545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MUA22_RS00560	COG3655	Transcriptional regulator
MUA22_RS00570	COG3177	Filamentation induced by cAMP protein fic
MUA22_RS00575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MUA22_RS00590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MUA22_RS00595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MUA22_RS00615	COG2235	arginine
MUA22_RS00630	COG2197	response regulator
MUA22_RS00635	COG4585	Histidine kinase
MUA22_RS00635	COG2203	Gaf domain
MUA22_RS00640	COG0842	Transport permease protein
MUA22_RS00645	COG1131	(ABC) transporter
MUA22_RS00665	COG0431	NADPH-dependent FMN reductase
MUA22_RS00675	COG3583	domain protein
MUA22_RS00675	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MUA22_RS00675	COG4932	domain protein
MUA22_RS00695	COG1353	crispr-associated protein
MUA22_RS00700	COG1421	Csm2 Type III-A
MUA22_RS00705	COG1337	RAMP superfamily
MUA22_RS00710	COG1567	CRISPR-associated RAMP protein, Csm4 family
MUA22_RS00715	COG1332	CRISPR-associated RAMP protein, Csm5 family
MUA22_RS00730	COG2226	methyltransferase
MUA22_RS00740	COG2508	Transcriptional regulator
MUA22_RS00745	COG1953	Uracil, thiamine, allantoin
MUA22_RS00750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MUA22_RS00755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA22_RS00765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA22_RS00770	COG3257	ureidoglycine aminohydrolase activity
MUA22_RS00775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MUA22_RS00780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MUA22_RS00785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MUA22_RS00790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MUA22_RS00805	COG2807	transmembrane transport
MUA22_RS00835	COG0657	acetylesterase activity
MUA22_RS00855	COG1609	Transcriptional regulator
MUA22_RS00865	COG0673	inositol 2-dehydrogenase activity
MUA22_RS00875	COG0366	Alpha amylase catalytic
MUA22_RS00885	COG3833	ABC-type maltose transport systems, permease component
MUA22_RS00890	COG1175	transmembrane transport
MUA22_RS00900	COG3842	ATPase activity
MUA22_RS00905	COG0475	glutathione-regulated potassium exporter activity
MUA22_RS00910	COG0490	domain, Protein
MUA22_RS00920	COG0346	lactoylglutathione lyase activity
MUA22_RS00930	COG0366	Alpha amylase catalytic
MUA22_RS00935	COG2188	Transcriptional regulator
MUA22_RS00940	COG2222	sugar isomerase
MUA22_RS00945	COG1105	Belongs to the carbohydrate kinase PfkB family
MUA22_RS00950	COG3684	Belongs to the aldolase LacD family
MUA22_RS00960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA22_RS00960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS00965	COG3715	PTS system
MUA22_RS00970	COG3716	PTS system mannose fructose sorbose family IID component
MUA22_RS00980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MUA22_RS01010	COG3314	Sporulation integral membrane protein YlbJ
MUA22_RS01030	COG1063	alcohol dehydrogenase
MUA22_RS01040	COG1620	l-lactate permease
MUA22_RS01045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MUA22_RS01050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MUA22_RS01055	COG0156	8-amino-7-oxononanoate synthase activity
MUA22_RS01100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MUA22_RS01110	COG2910	NAD(P)H-binding
MUA22_RS01115	COG2814	Major facilitator Superfamily
MUA22_RS01120	COG1335	isochorismatase
MUA22_RS01125	COG1309	transcriptional regulator
MUA22_RS01135	COG0076	glutamate decarboxylase activity
MUA22_RS01140	COG0076	glutamate decarboxylase activity
MUA22_RS01155	COG2318	DinB family
MUA22_RS01160	COG0753	catalase activity
MUA22_RS01170	COG0783	Belongs to the Dps family
MUA22_RS01180	COG0436	Aminotransferase
MUA22_RS01205	COG1136	(ABC) transporter
MUA22_RS01215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MUA22_RS01230	COG2814	Major facilitator Superfamily
MUA22_RS01245	COG0431	NADPH-dependent FMN reductase
MUA22_RS01260	COG1755	Isoprenylcysteine carboxyl methyltransferase
MUA22_RS01285	COG0579	oxidoreductase
MUA22_RS01305	COG1073	alpha beta
MUA22_RS01325	COG0438	transferase activity, transferring glycosyl groups
MUA22_RS01340	COG0183	Belongs to the thiolase family
MUA22_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
MUA22_RS01365	COG2814	Major facilitator Superfamily
MUA22_RS01370	COG1960	acyl-CoA dehydrogenase activity
MUA22_RS01375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MUA22_RS01405	COG1609	Transcriptional regulator
MUA22_RS01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MUA22_RS01415	COG1869	D-ribose catabolic process
MUA22_RS01420	COG1129	ABC transporter
MUA22_RS01425	COG1172	Belongs to the binding-protein-dependent transport system permease family
MUA22_RS01430	COG1879	ABC-type sugar transport system periplasmic component
MUA22_RS01440	COG2409	Drug exporters of the RND superfamily
MUA22_RS01475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS01475	COG3711	transcriptional antiterminator
MUA22_RS01480	COG2213	PTS system mannitol-specific
MUA22_RS01480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS01485	COG3414	Phosphotransferase system galactitol-specific IIB component
MUA22_RS01490	COG3775	system Galactitol-specific IIC component
MUA22_RS01495	COG1063	alcohol dehydrogenase
MUA22_RS01505	COG1063	alcohol dehydrogenase
MUA22_RS01510	COG3711	transcriptional antiterminator
MUA22_RS01515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS01525	COG3037	sugar-specific permease SgaT UlaA
MUA22_RS01535	COG1328	CTP reductase activity
MUA22_RS01545	COG3443	Belongs to the bacterial solute-binding protein 9 family
MUA22_RS01545	COG0803	Belongs to the bacterial solute-binding protein 9 family
MUA22_RS01580	COG2972	Histidine kinase
MUA22_RS01595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS01600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MUA22_RS01605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MUA22_RS01610	COG0477	Major facilitator Superfamily
MUA22_RS01615	COG2211	Major facilitator Superfamily
MUA22_RS01620	COG3250	beta-galactosidase activity
MUA22_RS01625	COG1957	nucleoside hydrolase
MUA22_RS01640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MUA22_RS01645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MUA22_RS01650	COG2807	transmembrane transport
MUA22_RS01655	COG1396	sequence-specific DNA binding
MUA22_RS01675	COG1785	Belongs to the alkaline phosphatase family
MUA22_RS01680	COG0494	nUDIX hydrolase
MUA22_RS01685	COG0556	nucleotide-excision repair
MUA22_RS01700	COG1510	regulation of RNA biosynthetic process
MUA22_RS01705	COG1012	belongs to the aldehyde dehydrogenase family
MUA22_RS01710	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MUA22_RS01720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MUA22_RS01730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MUA22_RS01745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MUA22_RS01750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MUA22_RS01755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MUA22_RS01760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MUA22_RS01780	COG1511	domain protein
MUA22_RS01805	COG2376	Dihydroxyacetone kinase
MUA22_RS01810	COG1461	Dihydroxyacetone kinase
MUA22_RS01815	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MUA22_RS01820	COG2824	Alkylphosphonate utilization operon protein PhnA
MUA22_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
MUA22_RS01850	COG0596	Alpha beta hydrolase
MUA22_RS01855	COG0789	Transcriptional regulator
MUA22_RS01860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA22_RS01860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA22_RS01860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS01870	COG1705	Flagellar rod assembly protein muramidase FlgJ
MUA22_RS01870	COG3942	CHAP domain
MUA22_RS01880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MUA22_RS01885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MUA22_RS01890	COG0747	negative chemotaxis
MUA22_RS01915	COG0463	Glycosyl transferase, family 2
MUA22_RS01915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS01920	COG0463	Glycosyl transferase, family 2
MUA22_RS01920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS01925	COG0438	transferase activity, transferring glycosyl groups
MUA22_RS01930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MUA22_RS01935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS01950	COG3181	Tripartite tricarboxylate transporter family receptor
MUA22_RS01955	COG0778	Nitroreductase
MUA22_RS01960	COG3001	Fructosamine kinase
MUA22_RS01985	COG1136	(ABC) transporter
MUA22_RS01990	COG0577	efflux transmembrane transporter activity
MUA22_RS02010	COG4413	Urea transporter
MUA22_RS02020	COG0832	Belongs to the urease beta subunit family
MUA22_RS02025	COG0804	urea catabolic process
MUA22_RS02030	COG0717	Belongs to the dCTP deaminase family
MUA22_RS02035	COG0523	cobalamin synthesis protein
MUA22_RS02060	COG1181	Belongs to the D-alanine--D-alanine ligase family
MUA22_RS02070	COG0583	DNA-binding transcription factor activity
MUA22_RS02080	COG1346	cytolysis
MUA22_RS02100	COG1846	Transcriptional regulator
MUA22_RS02105	COG0778	Nitroreductase
MUA22_RS02110	COG2357	RelA SpoT domain protein
MUA22_RS02145	COG1349	DNA-binding transcription factor activity
MUA22_RS02150	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
MUA22_RS02155	COG1070	Carbohydrate kinase
MUA22_RS02160	COG0235	Class ii aldolase
MUA22_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
MUA22_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
MUA22_RS02200	COG3835	regulator
MUA22_RS02210	COG3961	Belongs to the TPP enzyme family
MUA22_RS02215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MUA22_RS02220	COG0512	Glutamine amidotransferase of anthranilate synthase
MUA22_RS02230	COG0134	indole-3-glycerol-phosphate synthase activity
MUA22_RS02235	COG0135	phosphoribosylanthranilate isomerase activity
MUA22_RS02240	COG0133	tryptophan synthase activity
MUA22_RS02245	COG0159	tryptophan synthase activity
MUA22_RS02265	COG0277	FAD linked oxidase domain protein
MUA22_RS02270	COG0247	lactate metabolic process
MUA22_RS02275	COG1132	(ABC) transporter
MUA22_RS02280	COG1132	(ABC) transporter
MUA22_RS02285	COG0789	Transcriptional regulator
MUA22_RS02290	COG0346	lactoylglutathione lyase activity
MUA22_RS02295	COG3871	stress protein (general stress protein 26)
MUA22_RS02300	COG1115	amino acid carrier protein
MUA22_RS02305	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MUA22_RS02310	COG2814	Major facilitator Superfamily
MUA22_RS02315	COG2271	Major facilitator Superfamily
MUA22_RS02320	COG3764	Sortase (surface protein transpeptidase)
MUA22_RS02325	COG1929	Belongs to the glycerate kinase type-1 family
MUA22_RS02335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MUA22_RS02355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MUA22_RS02360	COG0702	epimerase
MUA22_RS02375	COG0444	Belongs to the ABC transporter superfamily
MUA22_RS02380	COG4608	Belongs to the ABC transporter superfamily
MUA22_RS02385	COG0601	transmembrane transport
MUA22_RS02390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MUA22_RS02405	COG1760	l-serine dehydratase
MUA22_RS02410	COG1760	l-serine dehydratase
MUA22_RS02440	COG0471	metal ion transport
MUA22_RS02445	COG2116	formate transmembrane transporter activity
MUA22_RS02450	COG0454	-acetyltransferase
MUA22_RS02460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MUA22_RS02460	COG1648	precorrin-2 dehydrogenase activity
MUA22_RS02465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MUA22_RS02470	COG2146	nitrite reductase [NAD(P)H] activity
MUA22_RS02475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MUA22_RS02475	COG1648	precorrin-2 dehydrogenase activity
MUA22_RS02480	COG0737	Belongs to the 5'-nucleotidase family
MUA22_RS02485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MUA22_RS02490	COG1140	nitrate reductase beta subunit
MUA22_RS02500	COG2181	nitrate reductase activity
MUA22_RS02510	COG4585	Histidine kinase
MUA22_RS02515	COG2197	response regulator
MUA22_RS02520	COG2223	nitrite transmembrane transporter activity
MUA22_RS02525	COG4187	Peptidase family M20/M25/M40
MUA22_RS02535	COG0039	L-malate dehydrogenase activity
MUA22_RS02540	COG1363	Peptidase, m42
MUA22_RS02545	COG0697	spore germination
MUA22_RS02555	COG2807	transmembrane transport
MUA22_RS02565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA22_RS02565	COG1263	PTS System
MUA22_RS02580	COG1283	sodium-dependent phosphate transmembrane transporter activity
MUA22_RS02610	COG2814	Major facilitator Superfamily
MUA22_RS02615	COG0604	alcohol dehydrogenase
MUA22_RS02630	COG1620	l-lactate permease
MUA22_RS02635	COG0438	transferase activity, transferring glycosyl groups
MUA22_RS02640	COG0579	oxidoreductase
MUA22_RS02655	COG0577	efflux transmembrane transporter activity
MUA22_RS02665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MUA22_RS02680	COG4640	response to antibiotic
MUA22_RS02690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MUA22_RS02700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA22_RS02725	COG1304	FMN binding
MUA22_RS02730	COG0523	cobalamin synthesis protein
MUA22_RS02735	COG0786	glutamate:sodium symporter activity
MUA22_RS02740	COG2207	Transcriptional regulator
MUA22_RS02765	COG1757	Na H antiporter
MUA22_RS02770	COG2094	Belongs to the DNA glycosylase MPG family
MUA22_RS02775	COG3152	Membrane
MUA22_RS02780	COG1288	antiporter activity
MUA22_RS02785	COG4152	abc transporter atp-binding protein
MUA22_RS02790	COG1668	transmembrane transport
MUA22_RS02795	COG1742	UPF0060 membrane protein
MUA22_RS02800	COG2017	converts alpha-aldose to the beta-anomer
MUA22_RS02805	COG2258	MOSC domain
MUA22_RS02810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MUA22_RS02820	COG1266	CAAX protease self-immunity
MUA22_RS02825	COG0583	DNA-binding transcription factor activity
MUA22_RS02830	COG3314	Sporulation integral membrane protein YlbJ
MUA22_RS02835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MUA22_RS02840	COG1228	amidohydrolase
MUA22_RS02845	COG0659	secondary active sulfate transmembrane transporter activity
MUA22_RS02850	COG1473	amidohydrolase
MUA22_RS02870	COG0385	Bile acid
MUA22_RS02880	COG0346	lactoylglutathione lyase activity
MUA22_RS02885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MUA22_RS02910	COG1113	amino acid transport
MUA22_RS02935	COG1316	TRANSCRIPTIONal
MUA22_RS02950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MUA22_RS02955	COG3383	formate dehydrogenase (NAD+) activity
MUA22_RS02980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA22_RS02985	COG2076	Multidrug Resistance protein
MUA22_RS02990	COG2076	Multidrug Resistance protein
MUA22_RS02995	COG3942	CHAP domain
MUA22_RS03005	COG1757	Na H antiporter
MUA22_RS03015	COG3942	CHAP domain
MUA22_RS03035	COG1960	acyl-CoA dehydrogenase activity
MUA22_RS03040	COG2832	Protein of unknown function (DUF454)
MUA22_RS03045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA22_RS03050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA22_RS03060	COG2186	Transcriptional regulator
MUA22_RS03070	COG1268	BioY protein
MUA22_RS03085	COG1609	Transcriptional regulator
MUA22_RS03090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MUA22_RS03095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MUA22_RS03100	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MUA22_RS03105	COG0725	ABC transporter, periplasmic molybdate-binding protein
MUA22_RS03110	COG4149	molybdate abc transporter
MUA22_RS03115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MUA22_RS03120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MUA22_RS03135	COG0303	'Molybdopterin
MUA22_RS03145	COG0314	molybdopterin synthase activity
MUA22_RS03155	COG0746	molybdenum cofactor guanylyltransferase activity
MUA22_RS03160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MUA22_RS03185	COG2348	transferase activity, transferring amino-acyl groups
MUA22_RS03190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MUA22_RS03195	COG0436	Aminotransferase
MUA22_RS03220	COG0551	DNA topoisomerase type I activity
MUA22_RS03220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MUA22_RS03225	COG2252	PERMEase
MUA22_RS03240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MUA22_RS03245	COG0088	Forms part of the polypeptide exit tunnel
MUA22_RS03250	COG0089	rRNA binding
MUA22_RS03255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MUA22_RS03260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MUA22_RS03265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MUA22_RS03270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MUA22_RS03275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MUA22_RS03280	COG0255	Belongs to the universal ribosomal protein uL29 family
MUA22_RS03290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MUA22_RS03305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MUA22_RS03310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MUA22_RS03315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MUA22_RS03325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MUA22_RS03330	COG1841	ribosomal large subunit assembly
MUA22_RS03340	COG0201	protein transport
MUA22_RS03355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MUA22_RS03365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MUA22_RS03370	COG0202	RNA polymerase activity
MUA22_RS03375	COG0203	ribosomal protein L17
MUA22_RS03380	COG1122	ATPase activity
MUA22_RS03385	COG1122	ATPase activity
MUA22_RS03395	COG0101	tRNA pseudouridine synthase activity
MUA22_RS03400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MUA22_RS03405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MUA22_RS03415	COG1335	isochorismatase
MUA22_RS03430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA22_RS03445	COG1302	Protein conserved in bacteria
MUA22_RS03450	COG2814	Major facilitator Superfamily
MUA22_RS03455	COG4264	IucA IucC family
MUA22_RS03460	COG2814	Major facilitator Superfamily
MUA22_RS03465	COG4264	IucA IucC family
MUA22_RS03470	COG3457	Alanine racemase
MUA22_RS03475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MUA22_RS03480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS03485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS03490	COG3314	Sporulation integral membrane protein YlbJ
MUA22_RS03500	COG1988	membrane-bound metal-dependent
MUA22_RS03505	COG4284	Utp--glucose-1-phosphate uridylyltransferase
MUA22_RS03510	COG1272	protein, Hemolysin III
MUA22_RS03530	COG2814	Major facilitator Superfamily
MUA22_RS03535	COG0489	protein tyrosine kinase activity
MUA22_RS03600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MUA22_RS03605	COG0246	Mannitol dehydrogenase
MUA22_RS03615	COG3711	transcriptional antiterminator
MUA22_RS03635	COG1119	ATPase activity
MUA22_RS03640	COG0561	phosphatase activity
MUA22_RS03650	COG2186	Transcriptional regulator
MUA22_RS03655	COG1482	cell wall glycoprotein biosynthetic process
MUA22_RS03670	COG1757	Na H antiporter
MUA22_RS03680	COG0813	purine-nucleoside phosphorylase activity
MUA22_RS03685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MUA22_RS03715	COG5146	pantothenate kinase activity
MUA22_RS03730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MUA22_RS03740	COG0504	CTP synthase activity
MUA22_RS03745	COG2271	Major facilitator Superfamily
MUA22_RS03750	COG4821	SIS domain
MUA22_RS03755	COG0191	fructose-bisphosphate aldolase activity
MUA22_RS03760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MUA22_RS03765	COG1733	regulation of RNA biosynthetic process
MUA22_RS03775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MUA22_RS03780	COG0254	rRNA binding
MUA22_RS03790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MUA22_RS03795	COG2890	protein-(glutamine-N5) methyltransferase activity
MUA22_RS03800	COG0009	L-threonylcarbamoyladenylate synthase
MUA22_RS03805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MUA22_RS03810	COG4475	Protein of unknown function (DUF436)
MUA22_RS03815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MUA22_RS03820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MUA22_RS03825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MUA22_RS03835	COG0356	it plays a direct role in the translocation of protons across the membrane
MUA22_RS03840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MUA22_RS03850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MUA22_RS03860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MUA22_RS03865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MUA22_RS03890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MUA22_RS03905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MUA22_RS03920	COG0352	thiamine-phosphate diphosphorylase activity
MUA22_RS03925	COG0706	membrane insertase activity
MUA22_RS03930	COG1418	mRNA catabolic process
MUA22_RS03935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MUA22_RS03940	COG1937	Protein conserved in bacteria
MUA22_RS03955	COG2217	Heavy metal translocating P-type atpase
MUA22_RS03970	COG0772	Belongs to the SEDS family
MUA22_RS03975	COG1181	Belongs to the D-alanine--D-alanine ligase family
MUA22_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MUA22_RS03985	COG0513	Belongs to the DEAD box helicase family
MUA22_RS04000	COG3402	PFAM membrane-flanked domain
MUA22_RS04005	COG0736	holo-[acyl-carrier-protein] synthase activity
MUA22_RS04010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MUA22_RS04020	COG2337	Toxic component of a toxin-antitoxin (TA) module
MUA22_RS04025	COG2208	phosphoserine phosphatase activity
MUA22_RS04030	COG1366	Belongs to the anti-sigma-factor antagonist family
MUA22_RS04040	COG1191	sigma factor activity
MUA22_RS04045	COG2183	response to ionizing radiation
MUA22_RS04050	COG3091	SprT-like family
MUA22_RS04090	COG0066	3-isopropylmalate dehydratase activity
MUA22_RS04095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MUA22_RS04100	COG0473	3-isopropylmalate dehydrogenase activity
MUA22_RS04105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MUA22_RS04110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MUA22_RS04120	COG0028	Belongs to the TPP enzyme family
MUA22_RS04125	COG0129	dihydroxy-acid dehydratase activity
MUA22_RS04130	COG0802	atpase or kinase
MUA22_RS04135	COG1214	PFAM Peptidase M22, glycoprotease
MUA22_RS04140	COG0456	acetyltransferase
MUA22_RS04145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MUA22_RS04150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MUA22_RS04155	COG0488	(ABC) transporter
MUA22_RS04160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MUA22_RS04165	COG0425	Belongs to the sulfur carrier protein TusA family
MUA22_RS04170	COG2391	methyltransferase activity
MUA22_RS04175	COG1609	Transcriptional regulator
MUA22_RS04180	COG1621	beta-fructofuranosidase activity
MUA22_RS04205	COG4512	PFAM Accessory gene regulator B
MUA22_RS04240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA22_RS04245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MUA22_RS04270	COG1131	(ABC) transporter
MUA22_RS04290	COG2610	gluconate transmembrane transporter activity
MUA22_RS04325	COG2706	6-phosphogluconolactonase activity
MUA22_RS04330	COG1012	belongs to the aldehyde dehydrogenase family
MUA22_RS04340	COG1227	inorganic diphosphatase activity
MUA22_RS04345	COG1335	isochorismatase
MUA22_RS04355	COG0077	Prephenate dehydratase
MUA22_RS04365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MUA22_RS04375	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MUA22_RS04385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MUA22_RS04390	COG4496	protein, YerC YecD
MUA22_RS04395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MUA22_RS04400	COG0210	DNA helicase
MUA22_RS04405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MUA22_RS04410	COG4851	CamS sex pheromone cAM373 precursor
MUA22_RS04415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA22_RS04420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MUA22_RS04430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MUA22_RS04435	COG1597	lipid kinase activity
MUA22_RS04440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MUA22_RS04450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MUA22_RS04460	COG1528	Iron-storage protein
MUA22_RS04475	COG4129	membrane
MUA22_RS04480	COG0024	Methionine aminopeptidase
MUA22_RS04505	COG0288	reversible hydration of carbon dioxide
MUA22_RS04510	COG1295	ribonuclease BN
MUA22_RS04525	COG4840	Belongs to the UPF0435 family
MUA22_RS04530	COG2309	aminopeptidase activity
MUA22_RS04535	COG1607	acyl-coa hydrolase
MUA22_RS04545	COG0535	radical SAM domain protein
MUA22_RS04555	COG0693	protein deglycase activity
MUA22_RS04560	COG0028	Belongs to the TPP enzyme family
MUA22_RS04565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MUA22_RS04580	COG1388	LysM domain
MUA22_RS04580	COG1134	teichoic acid transport
MUA22_RS04590	COG1988	membrane-bound metal-dependent
MUA22_RS04595	COG1194	a g-specific adenine glycosylase
MUA22_RS04600	COG3557	Belongs to the UPF0374 family
MUA22_RS04610	COG0069	glutamate synthase activity
MUA22_RS04615	COG4129	membrane
MUA22_RS04620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MUA22_RS04625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MUA22_RS04630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA22_RS04635	COG0735	belongs to the Fur family
MUA22_RS04795	COG0765	amino acid transport
MUA22_RS04800	COG1126	abc transporter atp-binding protein
MUA22_RS04805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MUA22_RS04810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MUA22_RS04815	COG0363	glucosamine-6-phosphate deaminase activity
MUA22_RS04830	COG0114	fumarate hydratase activity
MUA22_RS04835	COG0248	Ppx GppA phosphatase
MUA22_RS04840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MUA22_RS04845	COG0564	pseudouridine synthase activity
MUA22_RS04850	COG4585	Histidine kinase
MUA22_RS04850	COG2203	Gaf domain
MUA22_RS04855	COG2197	response regulator
MUA22_RS04865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MUA22_RS04885	COG4399	Belongs to the UPF0754 family
MUA22_RS04890	COG3679	Belongs to the UPF0342 family
MUA22_RS04895	COG0420	3'-5' exonuclease activity
MUA22_RS04905	COG3481	metal-dependent phosphohydrolase, HD sub domain
MUA22_RS04910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MUA22_RS04915	COG2814	Major facilitator Superfamily
MUA22_RS04925	COG1846	Transcriptional regulator
MUA22_RS04935	COG0537	adenosine 5'-monophosphoramidase activity
MUA22_RS04940	COG1131	(ABC) transporter
MUA22_RS04945	COG4473	ABC transporter
MUA22_RS04955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MUA22_RS04965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MUA22_RS04970	COG3545	Serine hydrolase
MUA22_RS05020	COG0582	viral genome integration into host DNA
MUA22_RS05125	COG0305	Participates in initiation and elongation during chromosome replication
MUA22_RS05160	COG0756	dUTP diphosphatase activity
MUA22_RS05265	COG0739	heme binding
MUA22_RS05330	COG0588	phosphoglycerate mutase activity
MUA22_RS05340	COG3037	sugar-specific permease SgaT UlaA
MUA22_RS05360	COG3623	hexulose-6-phosphate isomerase
MUA22_RS05365	COG0235	Class ii aldolase
MUA22_RS05385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MUA22_RS05390	COG0494	nUDIX hydrolase
MUA22_RS05395	COG1506	peptidase
MUA22_RS05405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MUA22_RS05410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MUA22_RS05420	COG0656	L-ascorbic acid biosynthetic process
MUA22_RS05440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MUA22_RS05465	COG3266	domain, Protein
MUA22_RS05465	COG4193	domain, Protein
MUA22_RS05465	COG5632	N-Acetylmuramoyl-L-alanine amidase
MUA22_RS05475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MUA22_RS05475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MUA22_RS05480	COG0307	riboflavin synthase, alpha
MUA22_RS05485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MUA22_RS05485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MUA22_RS05490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MUA22_RS05505	COG2267	carboxylic ester hydrolase activity
MUA22_RS05510	COG0039	L-malate dehydrogenase activity
MUA22_RS05520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MUA22_RS05525	COG1242	4 iron, 4 sulfur cluster binding
MUA22_RS05530	COG2814	Major facilitator Superfamily
MUA22_RS05535	COG0495	leucyl-tRNA aminoacylation
MUA22_RS05540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MUA22_RS05545	COG2081	HI0933 family
MUA22_RS05550	COG2244	polysaccharide biosynthetic process
MUA22_RS05555	COG1187	pseudouridine synthase activity
MUA22_RS05565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA22_RS05570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MUA22_RS05575	COG0510	thiamine kinase activity
MUA22_RS05580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MUA22_RS05585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MUA22_RS05595	COG1363	Peptidase, m42
MUA22_RS05600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA22_RS05605	COG4848	Belongs to the UPF0354 family
MUA22_RS05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MUA22_RS05615	COG1674	ftsk spoiiie
MUA22_RS05620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MUA22_RS05625	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MUA22_RS05635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MUA22_RS05635	COG1605	Chorismate mutase
MUA22_RS05640	COG1609	Transcriptional regulator
MUA22_RS05645	COG0123	including yeast histone deacetylase and acetoin utilization protein
MUA22_RS05650	COG0454	-acetyltransferase
MUA22_RS05655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MUA22_RS05660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MUA22_RS05665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MUA22_RS05675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MUA22_RS05680	COG0204	Acyl-transferase
MUA22_RS05690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MUA22_RS05695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MUA22_RS05700	COG1764	response to oxidative stress
MUA22_RS05760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MUA22_RS05765	COG1956	GAF domain-containing protein
MUA22_RS05770	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MUA22_RS05775	COG1104	cysteine desulfurase activity
MUA22_RS05780	COG0301	tRNA thio-modification
MUA22_RS05790	COG0616	signal peptide processing
MUA22_RS05795	COG1714	RDD family
MUA22_RS05800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MUA22_RS05805	COG0827	DNA restriction-modification system
MUA22_RS05810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MUA22_RS05815	COG0589	response to stress
MUA22_RS05820	COG0686	Belongs to the AlaDH PNT family
MUA22_RS05825	COG3142	Participates in the control of copper homeostasis
MUA22_RS05835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MUA22_RS05845	COG4109	DRTGG domain
MUA22_RS05850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MUA22_RS05855	COG0587	DNA-directed DNA polymerase activity
MUA22_RS05860	COG0281	malic enzyme
MUA22_RS05865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MUA22_RS05870	COG0825	malonyl-CoA metabolic process
MUA22_RS05875	COG0205	6-phosphofructokinase activity
MUA22_RS05880	COG0469	pyruvate kinase activity
MUA22_RS05885	COG0372	Belongs to the citrate synthase family
MUA22_RS05890	COG0538	isocitrate dehydrogenase activity
MUA22_RS05895	COG0745	RESPONSE REGULATOR receiver
MUA22_RS05900	COG5002	protein histidine kinase activity
MUA22_RS05905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA22_RS05905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA22_RS05915	COG0237	dephospho-CoA kinase activity
MUA22_RS05920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MUA22_RS05930	COG3611	Membrane attachment protein
MUA22_RS05935	COG1484	DNA-dependent DNA replication
MUA22_RS05945	COG0833	amino acid
MUA22_RS05950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MUA22_RS05955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MUA22_RS05975	COG0544	peptidyl-prolyl cis-trans isomerase activity
MUA22_RS05985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MUA22_RS05990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MUA22_RS06000	COG0181	hydroxymethylbilane synthase activity
MUA22_RS06015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MUA22_RS06025	COG2818	Glycosylase
MUA22_RS06030	COG0525	valine-tRNA ligase activity
MUA22_RS06035	COG0285	dihydrofolate synthase activity
MUA22_RS06050	COG2003	Belongs to the UPF0758 family
MUA22_RS06085	COG2868	ribosomal protein
MUA22_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MUA22_RS06105	COG0632	four-way junction helicase activity
MUA22_RS06115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MUA22_RS06125	COG1862	Preprotein translocase
MUA22_RS06130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MUA22_RS06130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MUA22_RS06135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MUA22_RS06135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MUA22_RS06140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MUA22_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
MUA22_RS06155	COG0860	N-Acetylmuramoyl-L-alanine amidase
MUA22_RS06165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MUA22_RS06175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MUA22_RS06180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MUA22_RS06185	COG1959	2 iron, 2 sulfur cluster binding
MUA22_RS06195	COG3237	CsbD-like
MUA22_RS06205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA22_RS06210	COG1104	cysteine desulfurase activity
MUA22_RS06215	COG0482	sulfurtransferase activity
MUA22_RS06225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MUA22_RS06230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MUA22_RS06235	COG4472	Bacterial protein of unknown function (DUF965)
MUA22_RS06240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MUA22_RS06245	COG3906	Belongs to the UPF0473 family
MUA22_RS06250	COG4122	O-methyltransferase activity
MUA22_RS06255	COG0826	peptidase U32
MUA22_RS06260	COG0826	peptidase U32
MUA22_RS06265	COG0572	uridine kinase
MUA22_RS06275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MUA22_RS06280	COG1984	allophanate hydrolase subunit 2
MUA22_RS06285	COG0511	ligase activity, forming carbon-carbon bonds
MUA22_RS06290	COG0439	Biotin carboxylase
MUA22_RS06295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MUA22_RS06300	COG1914	H( )-stimulated, divalent metal cation uptake system
MUA22_RS06305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MUA22_RS06310	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MUA22_RS06315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MUA22_RS06320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MUA22_RS06325	COG1534	Rna-binding protein
MUA22_RS06335	COG1713	HD superfamily hydrolase involved in NAD metabolism
MUA22_RS06340	COG0799	negative regulation of ribosome biogenesis
MUA22_RS06345	COG2226	methyltransferase
MUA22_RS06350	COG1555	photosystem II stabilization
MUA22_RS06350	COG1596	polysaccharide export
MUA22_RS06355	COG2131	deaminase
MUA22_RS06360	COG2333	competence protein COMEC
MUA22_RS06360	COG0658	competence protein
MUA22_RS06365	COG1466	dna polymerase III delta subunit
MUA22_RS06370	COG0268	Binds directly to 16S ribosomal RNA
MUA22_RS06380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MUA22_RS06400	COG0484	heat shock protein binding
MUA22_RS06405	COG2264	protein methyltransferase activity
MUA22_RS06410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MUA22_RS06415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MUA22_RS06425	COG1030	water channel activity
MUA22_RS06430	COG4864	UPF0365 protein
MUA22_RS06440	COG1702	phosphate starvation-inducible protein PhoH
MUA22_RS06450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MUA22_RS06455	COG0295	cytidine deaminase activity
MUA22_RS06460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MUA22_RS06465	COG1381	Involved in DNA repair and RecF pathway recombination
MUA22_RS06470	COG0423	glycine-tRNA ligase activity
MUA22_RS06475	COG0517	IMP dehydrogenase activity
MUA22_RS06480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MUA22_RS06485	COG0358	DNA primase activity
MUA22_RS06490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MUA22_RS06495	COG2384	SAM-dependent methyltransferase
MUA22_RS06500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MUA22_RS06505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MUA22_RS06510	COG0513	Belongs to the DEAD box helicase family
MUA22_RS06515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MUA22_RS06520	COG1121	(ABC) transporter
MUA22_RS06525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MUA22_RS06530	COG0735	belongs to the Fur family
MUA22_RS06535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MUA22_RS06545	COG0768	penicillin binding
MUA22_RS06550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MUA22_RS06555	COG0573	inorganic phosphate transmembrane transporter activity
MUA22_RS06560	COG0581	inorganic phosphate transmembrane transporter activity
MUA22_RS06565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MUA22_RS06570	COG0704	Plays a role in the regulation of phosphate uptake
MUA22_RS06580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MUA22_RS06585	COG0705	Rhomboid family
MUA22_RS06585	COG0457	Tetratricopeptide repeat
MUA22_RS06590	COG4483	Protein conserved in bacteria
MUA22_RS06595	COG1940	carbohydrate kinase activity
MUA22_RS06600	COG0011	TIGRFAM Protein of
MUA22_RS06605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MUA22_RS06610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MUA22_RS06640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MUA22_RS06645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MUA22_RS06655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MUA22_RS06660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MUA22_RS06665	COG0095	Lipoate-protein ligase
MUA22_RS06680	COG0006	proline dipeptidase activity
MUA22_RS06685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MUA22_RS06690	COG0511	ligase activity, forming carbon-carbon bonds
MUA22_RS06695	COG0439	Biotin carboxylase
MUA22_RS06700	COG1302	Protein conserved in bacteria
MUA22_RS06710	COG1570	exodeoxyribonuclease VII activity
MUA22_RS06725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MUA22_RS06730	COG1438	arginine binding
MUA22_RS06735	COG0497	DNA recombination
MUA22_RS06740	COG0280	phosphate acetyltransferase
MUA22_RS06745	COG3426	butyrate kinase activity
MUA22_RS06750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MUA22_RS06755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MUA22_RS06760	COG0022	dehydrogenase e1 component
MUA22_RS06765	COG0508	dehydrogenase complex catalyzes the overall conversion of
MUA22_RS06775	COG4129	membrane
MUA22_RS06785	COG2195	Cleaves the N-terminal amino acid of tripeptides
MUA22_RS06805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MUA22_RS06810	COG1234	tRNA 3'-trailer cleavage
MUA22_RS06815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MUA22_RS06825	COG0667	Aldo Keto reductase
MUA22_RS06830	COG0494	nUDIX hydrolase
MUA22_RS06835	COG0735	belongs to the Fur family
MUA22_RS06850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MUA22_RS06855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MUA22_RS06860	COG1187	pseudouridine synthase activity
MUA22_RS06865	COG0745	RESPONSE REGULATOR receiver
MUA22_RS06880	COG1141	Ferredoxin
MUA22_RS06890	COG0514	ATP-dependent DNA helicase (RecQ)
MUA22_RS06900	COG0492	ferredoxin-NADP+ reductase activity
MUA22_RS06910	COG0252	asparaginase activity
MUA22_RS06920	COG0539	negative regulation of cytoplasmic translation
MUA22_RS06925	COG1160	GTP binding
MUA22_RS06930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MUA22_RS06945	COG2226	methyltransferase
MUA22_RS06950	COG0142	geranyltranstransferase activity
MUA22_RS06955	COG0105	UTP biosynthetic process
MUA22_RS06965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MUA22_RS06975	COG0457	Tetratricopeptide repeat
MUA22_RS06985	COG4347	Protein of unknown function (DUF1405)
MUA22_RS06995	COG1694	Mazg nucleotide pyrophosphohydrolase
MUA22_RS07000	COG0438	transferase activity, transferring glycosyl groups
MUA22_RS07005	COG0617	tRNA 3'-terminal CCA addition
MUA22_RS07020	COG0017	Asparaginyl-tRNA synthetase
MUA22_RS07025	COG3935	DnaD domain protein
MUA22_RS07030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MUA22_RS07040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MUA22_RS07040	COG4499	WXG100 protein secretion system (Wss), protein YukC
MUA22_RS07055	COG4474	Belongs to the UPF0398 family
MUA22_RS07060	COG3599	regulation of cell shape
MUA22_RS07070	COG0116	Belongs to the methyltransferase superfamily
MUA22_RS07075	COG2962	Rard protein
MUA22_RS07080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MUA22_RS07085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA22_RS07095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MUA22_RS07105	COG1413	lyase activity
MUA22_RS07140	COG2190	(PTS) system
MUA22_RS07150	COG0793	Belongs to the peptidase S41A family
MUA22_RS07160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MUA22_RS07165	COG0671	phosphoesterase, PA-phosphatase related
MUA22_RS07175	COG5002	protein histidine kinase activity
MUA22_RS07180	COG0567	Dehydrogenase, E1 component
MUA22_RS07205	COG0714	Associated with various cellular activities
MUA22_RS07210	COG4548	von Willebrand factor, type A
MUA22_RS07215	COG1114	Component of the transport system for branched-chain amino acids
MUA22_RS07220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA22_RS07225	COG3853	Toxic anion resistance protein (TelA)
MUA22_RS07245	COG1278	Cold shock
MUA22_RS07260	COG1473	amidohydrolase
MUA22_RS07265	COG2171	N-acyltransferase activity
MUA22_RS07270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MUA22_RS07275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MUA22_RS07280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MUA22_RS07285	COG0488	(ABC) transporter
MUA22_RS07290	COG2996	Protein conserved in bacteria
MUA22_RS07320	COG1363	Peptidase, m42
MUA22_RS07325	COG0287	Prephenate dehydrogenase
MUA22_RS07330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MUA22_RS07360	COG0628	permease
MUA22_RS07370	COG3711	transcriptional antiterminator
MUA22_RS07375	COG1115	amino acid carrier protein
MUA22_RS07380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MUA22_RS07390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MUA22_RS07395	COG4841	protein insertion into membrane
MUA22_RS07400	COG0824	Thioesterase
MUA22_RS07410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA22_RS07415	COG1970	mechanosensitive ion channel activity
MUA22_RS07420	COG0419	ATPase involved in DNA repair
MUA22_RS07425	COG0420	3'-5' exonuclease activity
MUA22_RS07430	COG4846	Membrane protein involved in cytochrome C biogenesis
MUA22_RS07435	COG3763	UPF0154 protein
MUA22_RS07445	COG4224	UPF0291 protein
MUA22_RS07455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MUA22_RS07465	COG0516	GMP reductase activity
MUA22_RS07470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MUA22_RS07480	COG0833	amino acid
MUA22_RS07495	COG0083	homoserine kinase activity
MUA22_RS07500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MUA22_RS07505	COG0460	homoserine dehydrogenase
MUA22_RS07510	COG0527	aspartate kinase activity
MUA22_RS07530	COG1525	nuclease
MUA22_RS07560	COG0584	glycerophosphoryl diester phosphodiesterase
MUA22_RS07605	COG0789	Transcriptional regulator
MUA22_RS07610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MUA22_RS07615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MUA22_RS07620	COG0386	Belongs to the glutathione peroxidase family
MUA22_RS07630	COG2267	carboxylic ester hydrolase activity
MUA22_RS07635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MUA22_RS07640	COG1923	regulation of RNA biosynthetic process
MUA22_RS07645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MUA22_RS07655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MUA22_RS07660	COG1619	proteins homologs of microcin C7 resistance protein MccF
MUA22_RS07665	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MUA22_RS07670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MUA22_RS07690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MUA22_RS07700	COG1013	pyruvate-flavodoxin oxidoreductase activity
MUA22_RS07705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MUA22_RS07705	COG0674	pyruvate-flavodoxin oxidoreductase activity
MUA22_RS07710	COG1692	metallophosphoesterase
MUA22_RS07730	COG1418	mRNA catabolic process
MUA22_RS07735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MUA22_RS07740	COG1058	Belongs to the CinA family
MUA22_RS07740	COG1546	Belongs to the CinA family
MUA22_RS07760	COG0300	oxidoreductase activity
MUA22_RS07765	COG0612	Peptidase, M16
MUA22_RS07770	COG0612	Peptidase, M16
MUA22_RS07775	COG2188	Transcriptional regulator
MUA22_RS07790	COG1185	polyribonucleotide nucleotidyltransferase activity
MUA22_RS07800	COG0196	riboflavin kinase activity
MUA22_RS07805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MUA22_RS07810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MUA22_RS07830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MUA22_RS07835	COG1358	cellular component organization or biogenesis
MUA22_RS07840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MUA22_RS07845	COG0195	Participates in both transcription termination and antitermination
MUA22_RS07850	COG0779	Required for maturation of 30S ribosomal subunits
MUA22_RS07860	COG0442	prolyl-tRNA aminoacylation
MUA22_RS07870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MUA22_RS07875	COG4589	Belongs to the CDS family
MUA22_RS07885	COG0233	cytoplasmic translational termination
MUA22_RS07890	COG0528	UMP kinase activity
MUA22_RS07895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MUA22_RS07900	COG0052	Belongs to the universal ribosomal protein uS2 family
MUA22_RS07905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MUA22_RS07910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MUA22_RS07915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MUA22_RS07920	COG4974	Belongs to the 'phage' integrase family
MUA22_RS07925	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MUA22_RS07930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MUA22_RS07935	COG0758	DNA mediated transformation
MUA22_RS07945	COG0045	succinate-CoA ligase (ADP-forming) activity
MUA22_RS07955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MUA22_RS07970	COG4485	Bacterial membrane protein, YfhO
MUA22_RS07995	COG0336	Belongs to the RNA methyltransferase TrmD family
MUA22_RS08000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MUA22_RS08005	COG0228	four-way junction DNA binding
MUA22_RS08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MUA22_RS08040	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MUA22_RS08045	COG0552	protein localization to endoplasmic reticulum
MUA22_RS08050	COG1196	nuclear chromosome segregation
MUA22_RS08055	COG0571	ribonuclease III activity
MUA22_RS08060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MUA22_RS08075	COG0416	fatty acid biosynthetic process
MUA22_RS08080	COG1349	DNA-binding transcription factor activity
MUA22_RS08090	COG1760	l-serine dehydratase
MUA22_RS08095	COG1760	l-serine dehydratase
MUA22_RS08100	COG1461	Dihydroxyacetone kinase
MUA22_RS08105	COG1302	Protein conserved in bacteria
MUA22_RS08120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MUA22_RS08125	COG1162	GTPase activity
MUA22_RS08130	COG2124	cytochrome p450
MUA22_RS08145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MUA22_RS08150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MUA22_RS08150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MUA22_RS08155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MUA22_RS08160	COG0242	peptide deformylase activity
MUA22_RS08165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MUA22_RS08170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MUA22_RS08175	COG1758	RNA polymerase activity
MUA22_RS08200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MUA22_RS08205	COG0284	orotidine-5'-phosphate decarboxylase activity
MUA22_RS08210	COG0167	dihydroorotate dehydrogenase activity
MUA22_RS08220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MUA22_RS08225	COG0505	Belongs to the CarA family
MUA22_RS08245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MUA22_RS08250	COG0564	pseudouridine synthase activity
MUA22_RS08255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MUA22_RS08260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MUA22_RS08265	COG3599	regulation of cell shape
MUA22_RS08275	COG0673	inositol 2-dehydrogenase activity
MUA22_RS08285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA22_RS08290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MUA22_RS08305	COG0762	integral membrane protein
MUA22_RS08310	COG1799	cell septum assembly
MUA22_RS08315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MUA22_RS08325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MUA22_RS08330	COG0849	cell division
MUA22_RS08340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MUA22_RS08350	COG0768	penicillin binding
MUA22_RS08355	COG4839	cell division protein FtsL
MUA22_RS08360	COG0275	rRNA processing
MUA22_RS08365	COG2001	Belongs to the MraZ family
MUA22_RS08370	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MUA22_RS08375	COG0454	-acetyltransferase
MUA22_RS08380	COG1011	Hydrolase
MUA22_RS08390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MUA22_RS08410	COG1388	LysM domain
MUA22_RS08410	COG0860	N-Acetylmuramoyl-L-alanine amidase
MUA22_RS08520	COG2369	cell adhesion
MUA22_RS08530	COG1783	phage Terminase large subunit
MUA22_RS08565	COG0756	dUTP diphosphatase activity
MUA22_RS08605	COG0305	Participates in initiation and elongation during chromosome replication
MUA22_RS08700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MUA22_RS08720	COG0582	viral genome integration into host DNA
MUA22_RS08770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MUA22_RS08775	COG1053	succinate dehydrogenase
MUA22_RS08780	COG2009	succinate dehydrogenase
MUA22_RS08785	COG0322	excinuclease ABC activity
MUA22_RS08790	COG3118	belongs to the thioredoxin family
MUA22_RS08795	COG1193	negative regulation of DNA recombination
MUA22_RS08800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MUA22_RS08800	COG1796	DNA polymerase
MUA22_RS08815	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MUA22_RS08830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MUA22_RS08835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MUA22_RS08840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MUA22_RS08860	COG0742	ribosomal rna small subunit methyltransferase
MUA22_RS08870	COG4471	UPF0298 protein
MUA22_RS08875	COG0584	glycerophosphoryl diester phosphodiesterase
MUA22_RS08880	COG3679	Belongs to the UPF0342 family
MUA22_RS08900	COG0109	protoheme IX farnesyltransferase activity
MUA22_RS08905	COG1612	heme a metabolic process
MUA22_RS08925	COG0772	Belongs to the SEDS family
MUA22_RS08930	COG4838	Belongs to the UPF0358 family
MUA22_RS08935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MUA22_RS08940	COG4896	Protein conserved in bacteria
MUA22_RS08945	COG1902	pentaerythritol trinitrate reductase activity
MUA22_RS08950	COG1217	gtp-binding protein TYPA
MUA22_RS08960	COG0483	inositol monophosphate 1-phosphatase activity
MUA22_RS08965	COG4493	Belongs to the UPF0637 family
MUA22_RS08980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MUA22_RS08985	COG1177	transmembrane transport
MUA22_RS08995	COG3842	ATPase activity
MUA22_RS09005	COG4476	Belongs to the UPF0223 family
MUA22_RS09045	COG5503	Protein of unknown function (DUF1447)
MUA22_RS09050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MUA22_RS09055	COG0569	domain protein
MUA22_RS09060	COG1294	oxidase, subunit
MUA22_RS09065	COG1271	oxidase subunit
MUA22_RS09070	COG1393	Belongs to the ArsC family
MUA22_RS09075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MUA22_RS09080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS09090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MUA22_RS09110	COG4172	Belongs to the ABC transporter superfamily
MUA22_RS09120	COG0151	Belongs to the GarS family
MUA22_RS09125	COG0138	bifunctional purine biosynthesis protein purh
MUA22_RS09135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MUA22_RS09140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MUA22_RS09150	COG0047	phosphoribosylformylglycinamidine synthase activity
MUA22_RS09155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MUA22_RS09160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MUA22_RS09165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MUA22_RS09170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MUA22_RS09175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MUA22_RS09180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MUA22_RS09180	COG1017	nitric oxide dioxygenase activity
MUA22_RS09190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MUA22_RS09200	COG1845	cytochrome c oxidase, subunit III
MUA22_RS09205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MUA22_RS09225	COG1134	teichoic acid transport
MUA22_RS09250	COG1215	transferase activity, transferring glycosyl groups
MUA22_RS09265	COG1682	transport, permease protein
MUA22_RS09270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MUA22_RS09280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MUA22_RS09285	COG1316	TRANSCRIPTIONal
MUA22_RS09315	COG3594	Acyltransferase
MUA22_RS09320	COG0436	Aminotransferase
MUA22_RS09325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MUA22_RS09335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MUA22_RS09340	COG1169	isochorismate synthase
MUA22_RS09345	COG1575	Belongs to the MenA family. Type 1 subfamily
MUA22_RS09350	COG0390	transport system, permease component
MUA22_RS09355	COG4619	ABC transporter
MUA22_RS09375	COG4873	Protein conserved in bacteria
MUA22_RS09405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MUA22_RS09405	COG3266	domain, Protein
MUA22_RS09405	COG4932	domain protein
MUA22_RS09410	COG0737	Belongs to the 5'-nucleotidase family
MUA22_RS09420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MUA22_RS09425	COG1696	Membrane protein involved in D-alanine export
MUA22_RS09435	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MUA22_RS09440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MUA22_RS09445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MUA22_RS09450	COG0861	Integral membrane protein TerC family
MUA22_RS09455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MUA22_RS09465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MUA22_RS09470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MUA22_RS09475	COG2814	Major facilitator Superfamily
MUA22_RS09485	COG3715	PTS system
MUA22_RS09490	COG3716	PTS system mannose fructose sorbose family IID component
MUA22_RS09495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MUA22_RS09500	COG2382	esterase
MUA22_RS09510	COG0628	permease
MUA22_RS09520	COG0569	domain protein
MUA22_RS09520	COG0475	glutathione-regulated potassium exporter activity
MUA22_RS09525	COG2239	Acts as a magnesium transporter
MUA22_RS09530	COG0564	pseudouridine synthase activity
MUA22_RS09540	COG2357	RelA SpoT domain protein
MUA22_RS09555	COG2346	COG2346, Truncated hemoglobins
MUA22_RS09560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MUA22_RS09565	COG1164	Oligoendopeptidase f
MUA22_RS09580	COG1393	Belongs to the ArsC family
MUA22_RS09585	COG0180	Tryptophanyl-tRNA synthetase
MUA22_RS09590	COG4166	transmembrane transport
MUA22_RS09595	COG4608	Belongs to the ABC transporter superfamily
MUA22_RS09600	COG0444	Belongs to the ABC transporter superfamily
MUA22_RS09605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MUA22_RS09610	COG0601	transmembrane transport
MUA22_RS09640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MUA22_RS09660	COG0561	phosphatase activity
MUA22_RS09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
MUA22_RS09675	COG0179	Fumarylacetoacetate (FAA) hydrolase
MUA22_RS09685	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MUA22_RS09700	COG0166	Belongs to the GPI family
MUA22_RS09705	COG0137	argininosuccinate synthase activity
MUA22_RS09715	COG0584	glycerophosphoryl diester phosphodiesterase
MUA22_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
MUA22_RS09740	COG1098	S1 RNA binding domain
MUA22_RS09750	COG1278	Cold shock
MUA22_RS09760	COG1278	Cold shock
MUA22_RS09780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MUA22_RS09790	COG2111	Na H antiporter
MUA22_RS09790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MUA22_RS09795	COG2111	Na H antiporter
MUA22_RS09800	COG1006	Multisubunit Na H antiporter MnhC subunit
MUA22_RS09805	COG0651	ATP synthesis coupled electron transport
MUA22_RS09810	COG1863	multisubunit Na H antiporter MnhE subunit
MUA22_RS09815	COG2212	antiporter activity
MUA22_RS09820	COG1320	monovalent cation:proton antiporter activity
MUA22_RS09830	COG2056	Na+-H+ antiporter family
MUA22_RS09835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MUA22_RS09840	COG1252	NADH dehydrogenase
MUA22_RS09845	COG0316	Belongs to the HesB IscA family
MUA22_RS09850	COG4844	belongs to the
MUA22_RS09855	COG1252	NADH dehydrogenase
MUA22_RS09860	COG4837	Protein of unknown function (DUF1462)
MUA22_RS09865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MUA22_RS09870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA22_RS09875	COG0647	UMP catabolic process
MUA22_RS09880	COG2445	Protein of unknown function DUF86
MUA22_RS09890	COG4470	Protein conserved in bacteria
MUA22_RS09895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MUA22_RS09900	COG0737	Belongs to the 5'-nucleotidase family
MUA22_RS09905	COG0730	response to heat
MUA22_RS09910	COG1801	Protein of unknown function DUF72
MUA22_RS09920	COG2070	2-Nitropropane dioxygenase
MUA22_RS09925	COG1253	flavin adenine dinucleotide binding
MUA22_RS09935	COG0719	Fe-S assembly protein
MUA22_RS09940	COG0822	iron-sulfur transferase activity
MUA22_RS09950	COG0719	Fe-S assembly protein
MUA22_RS09955	COG0396	ATPase activity
MUA22_RS09970	COG1464	Belongs to the NlpA lipoprotein family
MUA22_RS09975	COG1464	Belongs to the NlpA lipoprotein family
MUA22_RS09980	COG2011	ABC-type metal ion transport system permease component
MUA22_RS09995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MUA22_RS10005	COG1393	Belongs to the ArsC family
MUA22_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA22_RS10020	COG0710	3-dehydroquinate dehydratase activity
MUA22_RS10030	COG1764	response to oxidative stress
MUA22_RS10045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MUA22_RS10075	COG0860	N-Acetylmuramoyl-L-alanine amidase
MUA22_RS10075	COG1388	LysM domain
MUA22_RS10110	COG0739	heme binding
MUA22_RS10340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MUA22_RS10370	COG0557	exoribonuclease II activity
MUA22_RS10375	COG1647	Serine aminopeptidase, S33
MUA22_RS10380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MUA22_RS10395	COG0148	phosphopyruvate hydratase activity
MUA22_RS10400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MUA22_RS10405	COG0149	triose-phosphate isomerase activity
MUA22_RS10410	COG0126	phosphoglycerate kinase activity
MUA22_RS10435	COG1090	epimerase
MUA22_RS10445	COG0740	serine-type endopeptidase activity
MUA22_RS10465	COG1481	regulation of sporulation
MUA22_RS10470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MUA22_RS10475	COG1660	Displays ATPase and GTPase activities
MUA22_RS10490	COG0110	maltose O-acetyltransferase activity
MUA22_RS10495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MUA22_RS10500	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MUA22_RS10535	COG0653	protein targeting
MUA22_RS10540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MUA22_RS10550	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MUA22_RS10560	COG1739	Uncharacterized protein family UPF0029
MUA22_RS10565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MUA22_RS10570	COG2199	diguanylate cyclase activity
MUA22_RS10585	COG2195	Cleaves the N-terminal amino acid of tripeptides
MUA22_RS10590	COG1929	Belongs to the glycerate kinase type-1 family
MUA22_RS10595	COG3118	belongs to the thioredoxin family
MUA22_RS10610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MUA22_RS10620	COG0494	nUDIX hydrolase
MUA22_RS10625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MUA22_RS10630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MUA22_RS10650	COG3104	oligopeptide transport
MUA22_RS10655	COG3104	oligopeptide transport
MUA22_RS10670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MUA22_RS10675	COG1174	glycine betaine transport
MUA22_RS10680	COG1125	glycine betaine transport
MUA22_RS10680	COG0517	IMP dehydrogenase activity
MUA22_RS10685	COG0514	ATP-dependent DNA helicase (RecQ)
MUA22_RS10690	COG0488	(ABC) transporter
MUA22_RS10700	COG1368	sulfuric ester hydrolase activity
MUA22_RS10710	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MUA22_RS10730	COG0512	Glutamine amidotransferase of anthranilate synthase
MUA22_RS10740	COG0720	synthase
MUA22_RS10745	COG0602	queuosine metabolic process
MUA22_RS10760	COG0463	Glycosyl transferase, family 2
MUA22_RS10765	COG1253	flavin adenine dinucleotide binding
MUA22_RS10770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA22_RS10770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA22_RS10770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA22_RS10775	COG1105	Belongs to the carbohydrate kinase PfkB family
MUA22_RS10780	COG1349	DNA-binding transcription factor activity
MUA22_RS10800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MUA22_RS10805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS10825	COG0039	L-malate dehydrogenase activity
MUA22_RS10850	COG0523	cobalamin synthesis protein
MUA22_RS10860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MUA22_RS10865	COG4988	ABC transporter
MUA22_RS10870	COG1968	undecaprenyl-diphosphatase activity
MUA22_RS10880	COG1671	Belongs to the UPF0178 family
MUA22_RS10885	COG1611	Belongs to the LOG family
MUA22_RS10915	COG2839	Protein conserved in bacteria
MUA22_RS10920	COG2814	Major facilitator Superfamily
MUA22_RS10925	COG0583	DNA-binding transcription factor activity
MUA22_RS10940	COG0217	transcriptional regulatory protein
MUA22_RS10945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MUA22_RS10950	COG2022	thiamine diphosphate biosynthetic process
MUA22_RS10960	COG0352	thiamine-phosphate diphosphorylase activity
MUA22_RS10970	COG1388	LysM domain
MUA22_RS10970	COG3942	CHAP domain
MUA22_RS10975	COG0306	phosphate transporter
MUA22_RS10980	COG1392	Phosphate transport regulator
MUA22_RS10985	COG0577	efflux transmembrane transporter activity
MUA22_RS10990	COG1136	(ABC) transporter
MUA22_RS11000	COG0745	RESPONSE REGULATOR receiver
MUA22_RS11005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MUA22_RS11020	COG3949	Membrane
MUA22_RS11025	COG0477	Major facilitator Superfamily
MUA22_RS11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS11040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS11045	COG1120	ATPase activity
MUA22_RS11050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA22_RS11055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MUA22_RS11075	COG1132	(ABC) transporter
MUA22_RS11080	COG1686	Belongs to the peptidase S11 family
MUA22_RS11085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MUA22_RS11090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA22_RS11095	COG1682	transport, permease protein
MUA22_RS11105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MUA22_RS11110	COG0110	maltose O-acetyltransferase activity
MUA22_RS11120	COG1475	DNA binding
MUA22_RS11125	COG0019	diaminopimelate decarboxylase activity
MUA22_RS11135	COG4264	IucA IucC family
MUA22_RS11140	COG4264	IucA IucC family
MUA22_RS11145	COG2814	Major facilitator Superfamily
MUA22_RS11150	COG4264	IucA IucC family
MUA22_RS11155	COG2423	ornithine cyclodeaminase activity
MUA22_RS11165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA22_RS11170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS11175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS11185	COG1121	(ABC) transporter
MUA22_RS11190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MUA22_RS11195	COG0803	Belongs to the bacterial solute-binding protein 9 family
MUA22_RS11200	COG1320	monovalent cation:proton antiporter activity
MUA22_RS11205	COG2212	antiporter activity
MUA22_RS11210	COG1863	multisubunit Na H antiporter MnhE subunit
MUA22_RS11220	COG1006	Multisubunit Na H antiporter MnhC subunit
MUA22_RS11225	COG2111	Na H antiporter
MUA22_RS11230	COG2111	Na H antiporter
MUA22_RS11230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MUA22_RS11275	COG2267	carboxylic ester hydrolase activity
MUA22_RS11280	COG0546	phosphoglycolate phosphatase activity
MUA22_RS11285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA22_RS11290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA22_RS11295	COG2822	iron ion transport
MUA22_RS11300	COG2837	iron assimilation
MUA22_RS11305	COG0672	)-iron permease
MUA22_RS11310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MUA22_RS11320	COG0018	arginyl-trna synthetase
MUA22_RS11335	COG1078	dGTPase activity
MUA22_RS11345	COG4844	belongs to the
MUA22_RS11405	COG0471	metal ion transport
MUA22_RS11435	COG0280	phosphate acetyltransferase
MUA22_RS11440	COG0095	Lipoate-protein ligase
MUA22_RS11445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MUA22_RS11460	COG2814	Major facilitator Superfamily
MUA22_RS11465	COG1566	PFAM secretion protein HlyD family protein
MUA22_RS11475	COG2311	Membrane
MUA22_RS11490	COG2363	Small membrane protein
MUA22_RS11500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MUA22_RS11520	COG0183	Belongs to the thiolase family
MUA22_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
MUA22_RS11530	COG0588	phosphoglycerate mutase activity
MUA22_RS11535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MUA22_RS11540	COG3314	Sporulation integral membrane protein YlbJ
MUA22_RS11545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MUA22_RS11555	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MUA22_RS11570	COG1263	PTS System
MUA22_RS11570	COG2190	(PTS) system
MUA22_RS11570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA22_RS11585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MUA22_RS11590	COG1469	GTP cyclohydrolase I activity
MUA22_RS11595	COG1136	(ABC) transporter
MUA22_RS11595	COG0577	efflux transmembrane transporter activity
MUA22_RS11605	COG0561	phosphatase activity
MUA22_RS11615	COG1428	Deoxynucleoside kinase
MUA22_RS11620	COG1428	Deoxynucleoside kinase
MUA22_RS11625	COG0546	phosphoglycolate phosphatase activity
MUA22_RS11635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MUA22_RS11640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MUA22_RS11650	COG1473	amidohydrolase
MUA22_RS11655	COG3527	Alpha-acetolactate decarboxylase
MUA22_RS11660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MUA22_RS11665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MUA22_RS11670	COG0049	tRNA binding
MUA22_RS11675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MUA22_RS11685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MUA22_RS11690	COG0085	RNA polymerase activity
MUA22_RS11695	COG2813	Specifically methylates the guanine in position
MUA22_RS11705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MUA22_RS11710	COG0081	regulation of translation
MUA22_RS11715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MUA22_RS11720	COG0250	Participates in transcription elongation, termination and antitermination
MUA22_RS11725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MUA22_RS11730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MUA22_RS11750	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MUA22_RS11755	COG0215	cysteine-tRNA ligase activity
MUA22_RS11765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MUA22_RS11775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MUA22_RS11780	COG4956	integral membrane protein (PIN domain superfamily)
MUA22_RS11785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MUA22_RS11790	COG0542	response to heat
MUA22_RS11795	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MUA22_RS11800	COG3880	PFAM UvrB UvrC protein
MUA22_RS11810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MUA22_RS11820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MUA22_RS11825	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MUA22_RS11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MUA22_RS11835	COG1289	transmembrane transporter activity
MUA22_RS11925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MUA22_RS11930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MUA22_RS11950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MUA22_RS11955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MUA22_RS11970	COG1098	S1 RNA binding domain
MUA22_RS11980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MUA22_RS11985	COG3956	TIGRFAM MazG family protein
MUA22_RS11990	COG2244	polysaccharide biosynthetic process
MUA22_RS11995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MUA22_RS12000	COG0193	aminoacyl-tRNA hydrolase activity
MUA22_RS12010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MUA22_RS12015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MUA22_RS12020	COG2088	sporulation resulting in formation of a cellular spore
MUA22_RS12025	COG0251	oxidation-reduction process
MUA22_RS12030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MUA22_RS12035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MUA22_RS12040	COG4466	Protein conserved in bacteria
MUA22_RS12045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MUA22_RS12050	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MUA22_RS12055	COG0084	hydrolase, TatD family'
MUA22_RS12065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MUA22_RS12070	COG2827	Endonuclease containing a URI domain
MUA22_RS12075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MUA22_RS12080	COG4467	Involved in initiation control of chromosome replication
MUA22_RS12085	COG1774	PSP1 C-terminal conserved region
MUA22_RS12090	COG0470	DNA polymerase III
MUA22_RS12095	COG3870	Protein conserved in bacteria
MUA22_RS12100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MUA22_RS12105	COG1982	Orn Lys Arg decarboxylase major
MUA22_RS12125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MUA22_RS12130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MUA22_RS12135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MUA22_RS12150	COG2188	Transcriptional regulator
MUA22_RS12155	COG0366	Alpha amylase catalytic
MUA22_RS12160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA22_RS12160	COG1263	PTS System
MUA22_RS12175	COG0493	'glutamate synthase
MUA22_RS12180	COG0070	glutamate synthase
MUA22_RS12180	COG0069	glutamate synthase activity
MUA22_RS12180	COG0067	glutamate synthase
MUA22_RS12185	COG0583	DNA-binding transcription factor activity
MUA22_RS12200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MUA22_RS12215	COG1309	transcriptional regulator
MUA22_RS12230	COG0732	type I restriction modification DNA specificity domain
MUA22_RS12240	COG0626	cystathionine gamma-synthase activity
MUA22_RS12245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MUA22_RS12250	COG2272	Belongs to the type-B carboxylesterase lipase family
MUA22_RS12255	COG0733	neurotransmitter:sodium symporter activity
MUA22_RS12265	COG0745	RESPONSE REGULATOR receiver
MUA22_RS12270	COG2205	protein histidine kinase activity
MUA22_RS12275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MUA22_RS12280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MUA22_RS12290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MUA22_RS12295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MUA22_RS12300	COG0574	Belongs to the PEP-utilizing enzyme family
MUA22_RS12300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MUA22_RS12330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MUA22_RS12340	COG1486	melibiose metabolic process
MUA22_RS12345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA22_RS12345	COG1263	PTS System
MUA22_RS12360	COG2814	Major facilitator Superfamily
MUA22_RS12375	COG1124	(ABC) transporter
MUA22_RS12380	COG0444	Belongs to the ABC transporter superfamily
MUA22_RS12385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MUA22_RS12390	COG0601	transmembrane transport
MUA22_RS12395	COG0747	negative chemotaxis
MUA22_RS12415	COG0346	lactoylglutathione lyase activity
MUA22_RS12450	COG1525	nuclease
MUA22_RS12470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MUA22_RS12470	COG0519	Catalyzes the synthesis of GMP from XMP
MUA22_RS12475	COG0517	IMP dehydrogenase activity
MUA22_RS12475	COG0516	GMP reductase activity
MUA22_RS12480	COG2233	PERMEase
MUA22_RS12500	COG5183	chlorophyll binding
MUA22_RS12505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MUA22_RS12510	COG1823	symporter activity
MUA22_RS12515	COG0577	efflux transmembrane transporter activity
MUA22_RS12515	COG1136	(ABC) transporter
MUA22_RS12530	COG0778	Nitroreductase
MUA22_RS12535	COG0450	alkyl hydroperoxide reductase
MUA22_RS12540	COG3634	alkyl hydroperoxide reductase activity
MUA22_RS12550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MUA22_RS12560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MUA22_RS12565	COG2011	ABC-type metal ion transport system permease component
MUA22_RS12570	COG1464	Belongs to the NlpA lipoprotein family
MUA22_RS12575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MUA22_RS12580	COG0753	catalase activity
MUA22_RS12600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MUA22_RS12610	COG0360	Binds together with S18 to 16S ribosomal RNA
MUA22_RS12630	COG0012	GTP binding
MUA22_RS12635	COG4481	Protein conserved in bacteria
MUA22_RS12640	COG0668	transmembrane transport
MUA22_RS12645	COG1475	DNA binding
MUA22_RS12650	COG0626	cystathionine gamma-synthase activity
MUA22_RS12655	COG0626	cystathionine gamma-synthase activity
MUA22_RS12660	COG0646	methionine synthase
MUA22_RS12660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MUA22_RS12665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MUA22_RS12675	COG0829	nickel cation binding
MUA22_RS12685	COG0830	nickel cation binding
MUA22_RS12690	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MUA22_RS12700	COG0534	Mate efflux family protein
MUA22_RS12705	COG1966	Carbon starvation protein
MUA22_RS12715	COG2388	GCN5-related N-acetyl-transferase
MUA22_RS12720	COG1846	Transcriptional regulator
MUA22_RS12725	COG0346	lactoylglutathione lyase activity
MUA22_RS12730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MUA22_RS12735	COG0400	carboxylic ester hydrolase activity
MUA22_RS12750	COG1131	(ABC) transporter
MUA22_RS12785	COG0357	Ribosomal RNA small subunit methyltransferase G
MUA22_RS12790	COG0445	tRNA wobble uridine modification
MUA22_RS12795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MUA22_RS12800	COG0594	ribonuclease P activity