locus-tag	class	description
B4U56_RS00090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4U56_RS00095	COG0592	DNA-directed DNA polymerase activity
B4U56_RS00100	COG2501	S4 domain
B4U56_RS00105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U56_RS00110	COG0187	DNA topoisomerase II activity
B4U56_RS00115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U56_RS00120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4U56_RS00125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4U56_RS00145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U56_RS00155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4U56_RS00160	COG0359	binds to the 23S rRNA
B4U56_RS00165	COG0305	Participates in initiation and elongation during chromosome replication
B4U56_RS00170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B4U56_RS00190	COG0745	RESPONSE REGULATOR receiver
B4U56_RS00195	COG5002	protein histidine kinase activity
B4U56_RS00200	COG4863	YycH protein
B4U56_RS00210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4U56_RS00215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4U56_RS00260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U56_RS00285	COG0640	Transcriptional regulator
B4U56_RS00295	COG2217	Heavy metal translocating P-type atpase
B4U56_RS00340	COG0640	Transcriptional regulator
B4U56_RS00370	COG0659	secondary active sulfate transmembrane transporter activity
B4U56_RS00405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U56_RS00410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U56_RS00420	COG2235	arginine
B4U56_RS00430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4U56_RS00445	COG0747	negative chemotaxis
B4U56_RS00455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U56_RS00460	COG4172	Belongs to the ABC transporter superfamily
B4U56_RS00465	COG1124	(ABC) transporter
B4U56_RS00505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U56_RS00540	COG0668	transmembrane transport
B4U56_RS00545	COG0561	phosphatase activity
B4U56_RS00585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U56_RS00590	COG0579	oxidoreductase
B4U56_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS00610	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4U56_RS00620	COG2207	Transcriptional regulator
B4U56_RS00620	COG4753	response regulator
B4U56_RS00625	COG2972	Histidine kinase
B4U56_RS00650	COG3583	domain protein
B4U56_RS00650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4U56_RS00650	COG4932	domain protein
B4U56_RS00660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4U56_RS00670	COG0156	8-amino-7-oxononanoate synthase activity
B4U56_RS00675	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B4U56_RS00700	COG0523	cobalamin synthesis protein
B4U56_RS00725	COG1053	succinate dehydrogenase
B4U56_RS00725	COG0431	NADPH-dependent FMN reductase
B4U56_RS00725	COG3976	FMN-binding domain protein
B4U56_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS00740	COG1131	(ABC) transporter
B4U56_RS00775	COG0601	transmembrane transport
B4U56_RS00785	COG0444	Belongs to the ABC transporter superfamily
B4U56_RS00790	COG1124	(ABC) transporter
B4U56_RS00800	COG1882	Formate acetyltransferase
B4U56_RS00805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B4U56_RS00810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U56_RS00815	COG1114	Component of the transport system for branched-chain amino acids
B4U56_RS00820	COG1309	transcriptional regulator
B4U56_RS00825	COG3246	L-lysine catabolic process to acetate
B4U56_RS00830	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U56_RS00865	COG1288	antiporter activity
B4U56_RS00870	COG0549	Belongs to the carbamate kinase family
B4U56_RS00875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U56_RS00885	COG0346	lactoylglutathione lyase activity
B4U56_RS00890	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4U56_RS00895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4U56_RS00905	COG2376	Dihydroxyacetone kinase
B4U56_RS00910	COG1461	Dihydroxyacetone kinase
B4U56_RS00915	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B4U56_RS00925	COG2814	Major facilitator Superfamily
B4U56_RS00930	COG0583	DNA-binding transcription factor activity
B4U56_RS00940	COG2814	Major facilitator Superfamily
B4U56_RS00975	COG2814	Major facilitator Superfamily
B4U56_RS00990	COG2962	Rard protein
B4U56_RS00995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4U56_RS01000	COG0471	metal ion transport
B4U56_RS01005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U56_RS01010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U56_RS01015	COG0022	dehydrogenase e1 component
B4U56_RS01020	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U56_RS01040	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4U56_RS01045	COG1054	Belongs to the UPF0176 family
B4U56_RS01050	COG3386	PFAM SMP-30 Gluconolaconase
B4U56_RS01055	COG2353	YceI-like domain
B4U56_RS01065	COG0579	oxidoreductase
B4U56_RS01090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4U56_RS01095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4U56_RS01100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4U56_RS01105	COG0131	Imidazoleglycerol-phosphate dehydratase
B4U56_RS01110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4U56_RS01115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4U56_RS01120	COG0107	imidazoleglycerol-phosphate synthase activity
B4U56_RS01125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4U56_RS01125	COG0140	phosphoribosyl-ATP diphosphatase activity
B4U56_RS01130	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4U56_RS01140	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4U56_RS01150	COG0726	polysaccharide deacetylase
B4U56_RS01160	COG1215	transferase activity, transferring glycosyl groups
B4U56_RS01165	COG1309	transcriptional regulator
B4U56_RS01180	COG2814	Major facilitator Superfamily
B4U56_RS01185	COG0737	Belongs to the 5'-nucleotidase family
B4U56_RS01200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B4U56_RS01205	COG3639	organic phosphonate transmembrane transporter activity
B4U56_RS01225	COG0201	protein transport
B4U56_RS01235	COG1073	alpha beta
B4U56_RS01245	COG0653	protein targeting
B4U56_RS01250	COG0438	transferase activity, transferring glycosyl groups
B4U56_RS01275	COG2814	Major facilitator Superfamily
B4U56_RS01280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U56_RS01295	COG1764	response to oxidative stress
B4U56_RS01305	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4U56_RS01305	COG3942	CHAP domain
B4U56_RS01315	COG1482	cell wall glycoprotein biosynthetic process
B4U56_RS01320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U56_RS01320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U56_RS01320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U56_RS01325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U56_RS01325	COG3711	transcriptional antiterminator
B4U56_RS01355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U56_RS01365	COG1438	arginine binding
B4U56_RS01370	COG2235	arginine
B4U56_RS01375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U56_RS01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U56_RS01395	COG2843	Capsule synthesis protein
B4U56_RS01405	COG3961	Belongs to the TPP enzyme family
B4U56_RS01440	COG4195	phage-related replication protein
B4U56_RS01455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U56_RS01460	COG0702	epimerase
B4U56_RS01465	COG1785	Belongs to the alkaline phosphatase family
B4U56_RS01480	COG2205	protein histidine kinase activity
B4U56_RS01485	COG1136	(ABC) transporter
B4U56_RS01500	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U56_RS01525	COG1846	Transcriptional regulator
B4U56_RS01530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U56_RS01535	COG0386	Belongs to the glutathione peroxidase family
B4U56_RS01545	COG0175	sulfate reduction
B4U56_RS01550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4U56_RS01555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U56_RS01570	COG0730	response to heat
B4U56_RS01575	COG2046	Belongs to the sulfate adenylyltransferase family
B4U56_RS01580	COG0529	Catalyzes the synthesis of activated sulfate
B4U56_RS01590	COG1328	CTP reductase activity
B4U56_RS01595	COG0602	queuosine metabolic process
B4U56_RS01600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B4U56_RS01615	COG1510	regulation of RNA biosynthetic process
B4U56_RS01620	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS01625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B4U56_RS01630	COG1473	amidohydrolase
B4U56_RS01645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U56_RS01650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U56_RS01650	COG0574	Belongs to the PEP-utilizing enzyme family
B4U56_RS01655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B4U56_RS01660	COG0579	oxidoreductase
B4U56_RS01670	COG3588	fructose-bisphosphate aldolase
B4U56_RS01675	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U56_RS01710	COG0531	amino acid
B4U56_RS01715	COG0583	DNA-binding transcription factor activity
B4U56_RS01720	COG0039	L-malate dehydrogenase activity
B4U56_RS01725	COG0028	Belongs to the TPP enzyme family
B4U56_RS01730	COG3527	Alpha-acetolactate decarboxylase
B4U56_RS01740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B4U56_RS01745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4U56_RS01750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4U56_RS01765	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4U56_RS01780	COG0167	dihydroorotate dehydrogenase activity
B4U56_RS01785	COG3001	Fructosamine kinase
B4U56_RS01790	COG1113	amino acid transport
B4U56_RS01810	COG0741	lytic transglycosylase activity
B4U56_RS01820	COG3942	CHAP domain
B4U56_RS01830	COG0436	Aminotransferase
B4U56_RS01840	COG2608	mercury ion transmembrane transporter activity
B4U56_RS01845	COG2217	Heavy metal translocating P-type atpase
B4U56_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS01885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U56_RS01890	COG3425	synthase
B4U56_RS01910	COG0583	DNA-binding transcription factor activity
B4U56_RS01915	COG1380	Effector of murein hydrolase LrgA
B4U56_RS01920	COG1346	cytolysis
B4U56_RS01925	COG0028	Belongs to the TPP enzyme family
B4U56_RS01930	COG1263	PTS System
B4U56_RS01930	COG2190	(PTS) system
B4U56_RS01930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U56_RS01940	COG1063	alcohol dehydrogenase
B4U56_RS01950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U56_RS01965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U56_RS01975	COG2843	Capsule synthesis protein
B4U56_RS01990	COG4975	Glucose uptake
B4U56_RS01995	COG1869	D-ribose catabolic process
B4U56_RS02005	COG1070	Carbohydrate kinase
B4U56_RS02020	COG1760	l-serine dehydratase
B4U56_RS02025	COG1760	l-serine dehydratase
B4U56_RS02035	COG3764	Sortase (surface protein transpeptidase)
B4U56_RS02045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U56_RS02050	COG0778	Nitroreductase
B4U56_RS02060	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS02075	COG2514	catechol 2,3-dioxygenase activity
B4U56_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS02095	COG3949	Membrane
B4U56_RS02110	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B4U56_RS02115	COG0586	Pfam SNARE associated Golgi protein
B4U56_RS02120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U56_RS02125	COG2022	thiamine diphosphate biosynthetic process
B4U56_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U56_RS02145	COG2271	Major facilitator Superfamily
B4U56_RS02160	COG4876	unkown
B4U56_RS02165	COG2357	RelA SpoT domain protein
B4U56_RS02185	COG0789	Transcriptional regulator
B4U56_RS02190	COG2271	Major facilitator Superfamily
B4U56_RS02195	COG1802	Transcriptional regulator
B4U56_RS02205	COG2610	gluconate transmembrane transporter activity
B4U56_RS02210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U56_RS02215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U56_RS02220	COG0438	transferase activity, transferring glycosyl groups
B4U56_RS02225	COG0494	nUDIX hydrolase
B4U56_RS02230	COG0556	nucleotide-excision repair
B4U56_RS02245	COG4221	oxidoreductase activity
B4U56_RS02250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U56_RS02255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B4U56_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS02275	COG1363	Peptidase, m42
B4U56_RS02285	COG0069	glutamate synthase activity
B4U56_RS02300	COG4619	ABC transporter
B4U56_RS02305	COG0390	transport system, permease component
B4U56_RS02310	COG2814	Major facilitator Superfamily
B4U56_RS02315	COG2272	Belongs to the type-B carboxylesterase lipase family
B4U56_RS02320	COG0531	amino acid
B4U56_RS02330	COG1063	alcohol dehydrogenase
B4U56_RS02350	COG1174	glycine betaine transport
B4U56_RS02355	COG1346	cytolysis
B4U56_RS02360	COG1380	Effector of murein hydrolase LrgA
B4U56_RS02365	COG3279	Response regulator of the LytR AlgR family
B4U56_RS02370	COG3275	phosphorelay sensor kinase activity
B4U56_RS02380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4U56_RS02385	COG0706	membrane insertase activity
B4U56_RS02400	COG1113	amino acid transport
B4U56_RS02425	COG1929	Belongs to the glycerate kinase type-1 family
B4U56_RS02440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U56_RS02445	COG0588	phosphoglycerate mutase activity
B4U56_RS02455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U56_RS02460	COG0765	amino acid transport
B4U56_RS02465	COG1126	abc transporter atp-binding protein
B4U56_RS02475	COG2348	transferase activity, transferring amino-acyl groups
B4U56_RS02495	COG2116	formate transmembrane transporter activity
B4U56_RS02500	COG0454	-acetyltransferase
B4U56_RS02510	COG0747	negative chemotaxis
B4U56_RS02525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U56_RS02530	COG2146	nitrite reductase [NAD(P)H] activity
B4U56_RS02540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4U56_RS02545	COG1140	nitrate reductase beta subunit
B4U56_RS02555	COG2181	nitrate reductase activity
B4U56_RS02565	COG4585	Histidine kinase
B4U56_RS02570	COG2197	response regulator
B4U56_RS02575	COG2223	nitrite transmembrane transporter activity
B4U56_RS02580	COG1846	Transcriptional regulator
B4U56_RS02585	COG0778	Nitroreductase
B4U56_RS02605	COG3871	stress protein (general stress protein 26)
B4U56_RS02620	COG1263	PTS System
B4U56_RS02620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U56_RS02665	COG0604	alcohol dehydrogenase
B4U56_RS02670	COG0456	acetyltransferase
B4U56_RS02675	COG0463	Glycosyl transferase, family 2
B4U56_RS02675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U56_RS02685	COG0463	Glycosyl transferase, family 2
B4U56_RS02685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U56_RS02690	COG1620	l-lactate permease
B4U56_RS02695	COG0438	transferase activity, transferring glycosyl groups
B4U56_RS02700	COG0579	oxidoreductase
B4U56_RS02705	COG3850	Histidine kinase
B4U56_RS02705	COG5002	protein histidine kinase activity
B4U56_RS02710	COG0745	RESPONSE REGULATOR receiver
B4U56_RS02715	COG0577	efflux transmembrane transporter activity
B4U56_RS02720	COG1136	(ABC) transporter
B4U56_RS02735	COG4640	response to antibiotic
B4U56_RS02740	COG2814	Major facilitator Superfamily
B4U56_RS02750	COG1566	PFAM secretion protein HlyD family protein
B4U56_RS02755	COG2814	Major facilitator Superfamily
B4U56_RS02770	COG0657	acetylesterase activity
B4U56_RS02785	COG0598	Magnesium transport protein CorA
B4U56_RS02790	COG1304	FMN binding
B4U56_RS02795	COG0786	glutamate:sodium symporter activity
B4U56_RS02815	COG2094	Belongs to the DNA glycosylase MPG family
B4U56_RS02840	COG1069	ribulokinase activity
B4U56_RS02845	COG2017	converts alpha-aldose to the beta-anomer
B4U56_RS02850	COG2258	MOSC domain
B4U56_RS02855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B4U56_RS02865	COG1266	CAAX protease self-immunity
B4U56_RS02870	COG0010	Belongs to the arginase family
B4U56_RS02875	COG1473	amidohydrolase
B4U56_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS02885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U56_RS02905	COG1737	Transcriptional regulator
B4U56_RS02910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U56_RS02910	COG1263	PTS System
B4U56_RS02920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U56_RS02940	COG1113	amino acid transport
B4U56_RS02950	COG1263	PTS System
B4U56_RS02950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U56_RS02955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B4U56_RS02970	COG1266	CAAX protease self-immunity
B4U56_RS02975	COG2378	regulation of single-species biofilm formation
B4U56_RS02980	COG0483	inositol monophosphate 1-phosphatase activity
B4U56_RS02985	COG1316	TRANSCRIPTIONal
B4U56_RS03010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U56_RS03015	COG2076	Multidrug Resistance protein
B4U56_RS03020	COG2076	Multidrug Resistance protein
B4U56_RS03030	COG3942	CHAP domain
B4U56_RS03045	COG1757	Na H antiporter
B4U56_RS03050	COG3942	CHAP domain
B4U56_RS03075	COG0829	nickel cation binding
B4U56_RS03080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B4U56_RS03085	COG0830	nickel cation binding
B4U56_RS03090	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B4U56_RS03095	COG0804	urea catabolic process
B4U56_RS03100	COG0832	Belongs to the urease beta subunit family
B4U56_RS03105	COG0831	urea catabolic process
B4U56_RS03115	COG1960	acyl-CoA dehydrogenase activity
B4U56_RS03120	COG1957	nucleoside hydrolase
B4U56_RS03125	COG1268	BioY protein
B4U56_RS03140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4U56_RS03145	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4U56_RS03150	COG4149	molybdate abc transporter
B4U56_RS03155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B4U56_RS03160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U56_RS03165	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4U56_RS03170	COG0315	cyclic pyranopterin monophosphate synthase activity
B4U56_RS03175	COG0303	'Molybdopterin
B4U56_RS03185	COG0314	molybdopterin synthase activity
B4U56_RS03195	COG0746	molybdenum cofactor guanylyltransferase activity
B4U56_RS03200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4U56_RS03225	COG2814	Major facilitator Superfamily
B4U56_RS03245	COG2348	transferase activity, transferring amino-acyl groups
B4U56_RS03250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U56_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS03275	COG4975	Glucose uptake
B4U56_RS03280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U56_RS03280	COG0551	DNA topoisomerase type I activity
B4U56_RS03285	COG2252	PERMEase
B4U56_RS03300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4U56_RS03305	COG0088	Forms part of the polypeptide exit tunnel
B4U56_RS03310	COG0089	rRNA binding
B4U56_RS03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4U56_RS03320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4U56_RS03325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4U56_RS03330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4U56_RS03335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4U56_RS03345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4U56_RS03350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4U56_RS03355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B4U56_RS03360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4U56_RS03365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U56_RS03370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4U56_RS03375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4U56_RS03380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B4U56_RS03385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4U56_RS03390	COG1841	ribosomal large subunit assembly
B4U56_RS03395	COG0200	Binds to the 23S rRNA
B4U56_RS03400	COG0201	protein transport
B4U56_RS03405	COG0563	adenylate kinase activity
B4U56_RS03410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4U56_RS03415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4U56_RS03420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4U56_RS03425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4U56_RS03430	COG0202	RNA polymerase activity
B4U56_RS03435	COG0203	ribosomal protein L17
B4U56_RS03440	COG1122	ATPase activity
B4U56_RS03445	COG1122	ATPase activity
B4U56_RS03455	COG0101	tRNA pseudouridine synthase activity
B4U56_RS03460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4U56_RS03465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4U56_RS03470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4U56_RS03475	COG1349	DNA-binding transcription factor activity
B4U56_RS03480	COG0698	ribose 5-phosphate isomerase
B4U56_RS03485	COG0698	ribose 5-phosphate isomerase
B4U56_RS03490	COG1105	Belongs to the carbohydrate kinase PfkB family
B4U56_RS03495	COG3684	Belongs to the aldolase LacD family
B4U56_RS03500	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4U56_RS03505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U56_RS03505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U56_RS03510	COG2723	6-phospho-beta-galactosidase activity
B4U56_RS03520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U56_RS03525	COG2130	NADP-dependent
B4U56_RS03530	COG0604	alcohol dehydrogenase
B4U56_RS03545	COG1302	Protein conserved in bacteria
B4U56_RS03550	COG4264	IucA IucC family
B4U56_RS03555	COG2814	Major facilitator Superfamily
B4U56_RS03560	COG4264	IucA IucC family
B4U56_RS03565	COG3457	Alanine racemase
B4U56_RS03570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U56_RS03575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U56_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U56_RS03585	COG3314	Sporulation integral membrane protein YlbJ
B4U56_RS03590	COG2329	Antibiotic biosynthesis monooxygenase
B4U56_RS03600	COG1988	membrane-bound metal-dependent
B4U56_RS03605	COG4284	Utp--glucose-1-phosphate uridylyltransferase
B4U56_RS03625	COG2814	Major facilitator Superfamily
B4U56_RS03630	COG0489	protein tyrosine kinase activity
B4U56_RS03680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4U56_RS03690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U56_RS03695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4U56_RS03700	COG0561	phosphatase activity
B4U56_RS03720	COG0640	Transcriptional regulator
B4U56_RS03725	COG0702	epimerase
B4U56_RS03735	COG1482	cell wall glycoprotein biosynthetic process
B4U56_RS03760	COG0783	Belongs to the Dps family
B4U56_RS03765	COG0813	purine-nucleoside phosphorylase activity
B4U56_RS03770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U56_RS03775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B4U56_RS03780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B4U56_RS03790	COG1854	S-ribosylhomocysteine lyase activity
B4U56_RS03810	COG5146	pantothenate kinase activity
B4U56_RS03820	COG3343	RNA polymerase activity
B4U56_RS03825	COG0504	CTP synthase activity
B4U56_RS03840	COG0191	fructose-bisphosphate aldolase activity
B4U56_RS03845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U56_RS03850	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS03855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4U56_RS03860	COG0254	rRNA binding
B4U56_RS03865	COG1435	thymidine kinase activity
B4U56_RS03870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4U56_RS03875	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U56_RS03885	COG0009	L-threonylcarbamoyladenylate synthase
B4U56_RS03890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U56_RS03895	COG4475	Protein of unknown function (DUF436)
B4U56_RS03900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U56_RS03905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4U56_RS03910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4U56_RS03920	COG0356	it plays a direct role in the translocation of protons across the membrane
B4U56_RS03930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4U56_RS03935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U56_RS03940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4U56_RS03945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4U56_RS03950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U56_RS03955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4U56_RS03965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U56_RS03970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4U56_RS03980	COG0629	single-stranded DNA binding
B4U56_RS03985	COG1388	LysM domain
B4U56_RS03990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4U56_RS04000	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B4U56_RS04005	COG0352	thiamine-phosphate diphosphorylase activity
B4U56_RS04010	COG0706	membrane insertase activity
B4U56_RS04015	COG1418	mRNA catabolic process
B4U56_RS04020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U56_RS04025	COG1937	Protein conserved in bacteria
B4U56_RS04040	COG0772	Belongs to the SEDS family
B4U56_RS04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U56_RS04050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4U56_RS04055	COG0513	Belongs to the DEAD box helicase family
B4U56_RS04065	COG3428	Bacterial PH domain
B4U56_RS04070	COG3402	PFAM membrane-flanked domain
B4U56_RS04075	COG0736	holo-[acyl-carrier-protein] synthase activity
B4U56_RS04080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U56_RS04090	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4U56_RS04095	COG2208	phosphoserine phosphatase activity
B4U56_RS04110	COG1191	sigma factor activity
B4U56_RS04115	COG2183	response to ionizing radiation
B4U56_RS04120	COG3091	SprT-like family
B4U56_RS04160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4U56_RS04165	COG0066	3-isopropylmalate dehydratase activity
B4U56_RS04170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U56_RS04175	COG0473	3-isopropylmalate dehydrogenase activity
B4U56_RS04180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U56_RS04185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4U56_RS04195	COG0028	Belongs to the TPP enzyme family
B4U56_RS04200	COG0129	dihydroxy-acid dehydratase activity
B4U56_RS04205	COG0802	atpase or kinase
B4U56_RS04210	COG1214	PFAM Peptidase M22, glycoprotease
B4U56_RS04215	COG0456	acetyltransferase
B4U56_RS04220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4U56_RS04225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4U56_RS04230	COG0488	(ABC) transporter
B4U56_RS04235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4U56_RS04250	COG0425	Belongs to the sulfur carrier protein TusA family
B4U56_RS04255	COG0004	ammonium transporteR
B4U56_RS04260	COG1609	Transcriptional regulator
B4U56_RS04270	COG1621	beta-fructofuranosidase activity
B4U56_RS04275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U56_RS04280	COG3279	Response regulator of the LytR AlgR family
B4U56_RS04285	COG3290	protein histidine kinase activity
B4U56_RS04320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4U56_RS04325	COG0459	protein refolding
B4U56_RS04350	COG1725	Transcriptional regulator
B4U56_RS04355	COG1131	(ABC) transporter
B4U56_RS04365	COG1131	(ABC) transporter
B4U56_RS04410	COG2706	6-phosphogluconolactonase activity
B4U56_RS04415	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS04420	COG1227	inorganic diphosphatase activity
B4U56_RS04425	COG1335	isochorismatase
B4U56_RS04435	COG0077	Prephenate dehydratase
B4U56_RS04445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4U56_RS04450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U56_RS04455	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4U56_RS04465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4U56_RS04470	COG4496	protein, YerC YecD
B4U56_RS04475	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4U56_RS04480	COG0210	DNA helicase
B4U56_RS04485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4U56_RS04490	COG4851	CamS sex pheromone cAM373 precursor
B4U56_RS04495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U56_RS04500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U56_RS04505	COG0154	amidase activity
B4U56_RS04510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U56_RS04515	COG1597	lipid kinase activity
B4U56_RS04520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U56_RS04530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U56_RS04540	COG1528	Iron-storage protein
B4U56_RS04560	COG4129	membrane
B4U56_RS04565	COG0024	Methionine aminopeptidase
B4U56_RS04580	COG4585	Histidine kinase
B4U56_RS04585	COG2197	response regulator
B4U56_RS04590	COG1295	ribonuclease BN
B4U56_RS04600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U56_RS04605	COG4840	Belongs to the UPF0435 family
B4U56_RS04610	COG2309	aminopeptidase activity
B4U56_RS04615	COG1607	acyl-coa hydrolase
B4U56_RS04620	COG0535	radical SAM domain protein
B4U56_RS04630	COG0693	protein deglycase activity
B4U56_RS04635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U56_RS04640	COG2137	regulation of response to DNA damage stimulus
B4U56_RS04650	COG1134	teichoic acid transport
B4U56_RS04650	COG1388	LysM domain
B4U56_RS04660	COG1988	membrane-bound metal-dependent
B4U56_RS04670	COG3557	Belongs to the UPF0374 family
B4U56_RS04680	COG4129	membrane
B4U56_RS04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U56_RS04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4U56_RS04695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U56_RS04700	COG0735	belongs to the Fur family
B4U56_RS04855	COG0765	amino acid transport
B4U56_RS04860	COG1126	abc transporter atp-binding protein
B4U56_RS04865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4U56_RS04890	COG0114	fumarate hydratase activity
B4U56_RS04895	COG0564	pseudouridine synthase activity
B4U56_RS04900	COG4585	Histidine kinase
B4U56_RS04900	COG2203	Gaf domain
B4U56_RS04905	COG2197	response regulator
B4U56_RS04915	COG4399	Belongs to the UPF0754 family
B4U56_RS04920	COG3679	Belongs to the UPF0342 family
B4U56_RS04925	COG0420	3'-5' exonuclease activity
B4U56_RS04935	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4U56_RS04945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U56_RS04960	COG0537	adenosine 5'-monophosphoramidase activity
B4U56_RS04965	COG1131	(ABC) transporter
B4U56_RS04970	COG4473	ABC transporter
B4U56_RS04980	COG2329	Antibiotic biosynthesis monooxygenase
B4U56_RS04985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4U56_RS04990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4U56_RS04995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4U56_RS05050	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U56_RS05050	COG1388	LysM domain
B4U56_RS05090	COG0318	PFAM AMP-dependent synthetase and ligase
B4U56_RS05100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4U56_RS05105	COG0494	nUDIX hydrolase
B4U56_RS05110	COG1506	peptidase
B4U56_RS05115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4U56_RS05120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U56_RS05130	COG0656	L-ascorbic acid biosynthetic process
B4U56_RS05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U56_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U56_RS05150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U56_RS05180	COG4193	domain, Protein
B4U56_RS05180	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U56_RS05180	COG3266	domain, Protein
B4U56_RS05190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U56_RS05190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U56_RS05200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U56_RS05200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U56_RS05205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4U56_RS05210	COG0506	proline dehydrogenase activity
B4U56_RS05215	COG2267	carboxylic ester hydrolase activity
B4U56_RS05225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4U56_RS05230	COG1242	4 iron, 4 sulfur cluster binding
B4U56_RS05235	COG2814	Major facilitator Superfamily
B4U56_RS05240	COG0495	leucyl-tRNA aminoacylation
B4U56_RS05255	COG2081	HI0933 family
B4U56_RS05260	COG2244	polysaccharide biosynthetic process
B4U56_RS05265	COG1187	pseudouridine synthase activity
B4U56_RS05275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U56_RS05280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U56_RS05285	COG0510	thiamine kinase activity
B4U56_RS05290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4U56_RS05300	COG1363	Peptidase, m42
B4U56_RS05305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U56_RS05310	COG4848	Belongs to the UPF0354 family
B4U56_RS05315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U56_RS05320	COG1674	ftsk spoiiie
B4U56_RS05325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4U56_RS05330	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U56_RS05340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4U56_RS05340	COG1605	Chorismate mutase
B4U56_RS05345	COG1609	Transcriptional regulator
B4U56_RS05350	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B4U56_RS05360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U56_RS05365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U56_RS05370	COG0204	Acyl-transferase
B4U56_RS05375	COG1263	PTS System
B4U56_RS05375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U56_RS05385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U56_RS05390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4U56_RS05395	COG1764	response to oxidative stress
B4U56_RS05400	COG0584	glycerophosphoryl diester phosphodiesterase
B4U56_RS05405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4U56_RS05415	COG1956	GAF domain-containing protein
B4U56_RS05420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4U56_RS05430	COG0301	tRNA thio-modification
B4U56_RS05440	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4U56_RS05445	COG0827	DNA restriction-modification system
B4U56_RS05450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4U56_RS05460	COG0589	response to stress
B4U56_RS05465	COG0686	Belongs to the AlaDH PNT family
B4U56_RS05470	COG0006	proline dipeptidase activity
B4U56_RS05475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4U56_RS05485	COG4109	DRTGG domain
B4U56_RS05490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U56_RS05495	COG0587	DNA-directed DNA polymerase activity
B4U56_RS05500	COG0281	malic enzyme
B4U56_RS05505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4U56_RS05510	COG0825	malonyl-CoA metabolic process
B4U56_RS05515	COG0205	6-phosphofructokinase activity
B4U56_RS05520	COG0469	pyruvate kinase activity
B4U56_RS05525	COG1113	amino acid transport
B4U56_RS05530	COG0372	Belongs to the citrate synthase family
B4U56_RS05535	COG0538	isocitrate dehydrogenase activity
B4U56_RS05540	COG0745	RESPONSE REGULATOR receiver
B4U56_RS05545	COG5002	protein histidine kinase activity
B4U56_RS05550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U56_RS05550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U56_RS05555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U56_RS05560	COG0237	dephospho-CoA kinase activity
B4U56_RS05570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U56_RS05575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4U56_RS05580	COG3611	Membrane attachment protein
B4U56_RS05585	COG1484	DNA-dependent DNA replication
B4U56_RS05590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U56_RS05595	COG0833	amino acid
B4U56_RS05600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4U56_RS05605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4U56_RS05610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4U56_RS05625	COG4112	unkown
B4U56_RS05635	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4U56_RS05640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4U56_RS05645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4U56_RS05650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4U56_RS05660	COG0181	hydroxymethylbilane synthase activity
B4U56_RS05670	COG0113	porphobilinogen synthase activity
B4U56_RS05675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U56_RS05685	COG2818	Glycosylase
B4U56_RS05690	COG0525	valine-tRNA ligase activity
B4U56_RS05695	COG0285	dihydrofolate synthase activity
B4U56_RS05705	COG2003	Belongs to the UPF0758 family
B4U56_RS05735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B4U56_RS05740	COG2868	ribosomal protein
B4U56_RS05745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4U56_RS05750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4U56_RS05755	COG4492	Belongs to the UPF0735 family
B4U56_RS05760	COG0632	four-way junction helicase activity
B4U56_RS05765	COG2255	four-way junction helicase activity
B4U56_RS05770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4U56_RS05775	COG0343	queuine tRNA-ribosyltransferase activity
B4U56_RS05780	COG1862	Preprotein translocase
B4U56_RS05785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U56_RS05785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U56_RS05795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4U56_RS05795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U56_RS05800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U56_RS05810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U56_RS05815	COG1490	D-aminoacyl-tRNA deacylase activity
B4U56_RS05820	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U56_RS05825	COG0124	histidyl-tRNA synthetase
B4U56_RS05830	COG0124	histidyl-tRNA synthetase
B4U56_RS05835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4U56_RS05845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4U56_RS05850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4U56_RS05855	COG1959	2 iron, 2 sulfur cluster binding
B4U56_RS05865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U56_RS05870	COG1104	cysteine desulfurase activity
B4U56_RS05875	COG0482	sulfurtransferase activity
B4U56_RS05885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4U56_RS05890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U56_RS05895	COG4472	Bacterial protein of unknown function (DUF965)
B4U56_RS05900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4U56_RS05905	COG3906	Belongs to the UPF0473 family
B4U56_RS05915	COG0826	peptidase U32
B4U56_RS05920	COG0826	peptidase U32
B4U56_RS05925	COG0572	uridine kinase
B4U56_RS05930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4U56_RS05940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U56_RS05945	COG1984	allophanate hydrolase subunit 2
B4U56_RS05950	COG0511	ligase activity, forming carbon-carbon bonds
B4U56_RS05955	COG0439	Biotin carboxylase
B4U56_RS05960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4U56_RS05965	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U56_RS05970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U56_RS05975	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4U56_RS05980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4U56_RS05985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4U56_RS05990	COG1534	Rna-binding protein
B4U56_RS05995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4U56_RS06000	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4U56_RS06005	COG0799	negative regulation of ribosome biogenesis
B4U56_RS06010	COG2226	methyltransferase
B4U56_RS06020	COG2131	deaminase
B4U56_RS06025	COG0658	competence protein
B4U56_RS06025	COG2333	competence protein COMEC
B4U56_RS06030	COG1466	dna polymerase III delta subunit
B4U56_RS06035	COG0268	Binds directly to 16S ribosomal RNA
B4U56_RS06040	COG0481	GTPase activity
B4U56_RS06045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U56_RS06050	COG1420	regulation of RNA biosynthetic process
B4U56_RS06055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U56_RS06060	COG0443	Heat shock 70 kDa protein
B4U56_RS06065	COG0484	heat shock protein binding
B4U56_RS06070	COG2264	protein methyltransferase activity
B4U56_RS06075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4U56_RS06080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U56_RS06090	COG1030	water channel activity
B4U56_RS06095	COG4864	UPF0365 protein
B4U56_RS06105	COG1702	phosphate starvation-inducible protein PhoH
B4U56_RS06110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4U56_RS06115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4U56_RS06120	COG0295	cytidine deaminase activity
B4U56_RS06125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4U56_RS06130	COG1381	Involved in DNA repair and RecF pathway recombination
B4U56_RS06135	COG0423	glycine-tRNA ligase activity
B4U56_RS06140	COG0517	IMP dehydrogenase activity
B4U56_RS06145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B4U56_RS06150	COG0358	DNA primase activity
B4U56_RS06155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U56_RS06160	COG2384	SAM-dependent methyltransferase
B4U56_RS06165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4U56_RS06170	COG0513	Belongs to the DEAD box helicase family
B4U56_RS06175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4U56_RS06180	COG1121	(ABC) transporter
B4U56_RS06185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U56_RS06190	COG0735	belongs to the Fur family
B4U56_RS06195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U56_RS06205	COG0768	penicillin binding
B4U56_RS06210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U56_RS06215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4U56_RS06225	COG4483	Protein conserved in bacteria
B4U56_RS06230	COG1940	carbohydrate kinase activity
B4U56_RS06235	COG0011	TIGRFAM Protein of
B4U56_RS06245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4U56_RS06250	COG1459	type II secretion system
B4U56_RS06255	COG4537	Required for transformation and DNA binding
B4U56_RS06280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4U56_RS06285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4U56_RS06290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U56_RS06295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U56_RS06305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U56_RS06310	COG0095	Lipoate-protein ligase
B4U56_RS06325	COG0006	proline dipeptidase activity
B4U56_RS06330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4U56_RS06335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B4U56_RS06340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4U56_RS06345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B4U56_RS06350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U56_RS06355	COG0511	ligase activity, forming carbon-carbon bonds
B4U56_RS06360	COG0439	Biotin carboxylase
B4U56_RS06365	COG1302	Protein conserved in bacteria
B4U56_RS06370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U56_RS06375	COG1570	exodeoxyribonuclease VII activity
B4U56_RS06380	COG1722	exodeoxyribonuclease VII activity
B4U56_RS06390	COG1438	arginine binding
B4U56_RS06395	COG0497	DNA recombination
B4U56_RS06400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U56_RS06405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U56_RS06410	COG0022	dehydrogenase e1 component
B4U56_RS06415	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U56_RS06425	COG4129	membrane
B4U56_RS06430	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U56_RS06435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U56_RS06440	COG0366	Alpha amylase catalytic
B4U56_RS06455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U56_RS06460	COG1234	tRNA 3'-trailer cleavage
B4U56_RS06465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U56_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS06475	COG0667	Aldo Keto reductase
B4U56_RS06480	COG0494	nUDIX hydrolase
B4U56_RS06485	COG0735	belongs to the Fur family
B4U56_RS06490	COG4974	Belongs to the 'phage' integrase family
B4U56_RS06495	COG1547	Domain of unknown function (DUF309)
B4U56_RS06500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4U56_RS06505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4U56_RS06510	COG1187	pseudouridine synthase activity
B4U56_RS06515	COG0745	RESPONSE REGULATOR receiver
B4U56_RS06535	COG1141	Ferredoxin
B4U56_RS06545	COG0514	ATP-dependent DNA helicase (RecQ)
B4U56_RS06550	COG1388	LysM domain
B4U56_RS06555	COG0492	ferredoxin-NADP+ reductase activity
B4U56_RS06560	COG0252	asparaginase activity
B4U56_RS06565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4U56_RS06570	COG0539	negative regulation of cytoplasmic translation
B4U56_RS06575	COG1160	GTP binding
B4U56_RS06580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B4U56_RS06595	COG2226	methyltransferase
B4U56_RS06605	COG0105	UTP biosynthetic process
B4U56_RS06610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4U56_RS06615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4U56_RS06620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4U56_RS06630	COG5582	Belongs to the UPF0302 family
B4U56_RS06635	COG4347	Protein of unknown function (DUF1405)
B4U56_RS06640	COG2738	Putative neutral zinc metallopeptidase
B4U56_RS06645	COG1694	Mazg nucleotide pyrophosphohydrolase
B4U56_RS06650	COG0438	transferase activity, transferring glycosyl groups
B4U56_RS06655	COG0617	tRNA 3'-terminal CCA addition
B4U56_RS06660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4U56_RS06660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4U56_RS06665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4U56_RS06665	COG1199	ATP-dependent helicase activity
B4U56_RS06670	COG0017	Asparaginyl-tRNA synthetase
B4U56_RS06675	COG3935	DnaD domain protein
B4U56_RS06680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4U56_RS06690	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U56_RS06690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U56_RS06695	COG3331	DNA recombination
B4U56_RS06705	COG4474	Belongs to the UPF0398 family
B4U56_RS06710	COG3599	regulation of cell shape
B4U56_RS06720	COG0116	Belongs to the methyltransferase superfamily
B4U56_RS06730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U56_RS06735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U56_RS06755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4U56_RS06765	COG1413	lyase activity
B4U56_RS06780	COG1136	(ABC) transporter
B4U56_RS06805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U56_RS06810	COG2190	(PTS) system
B4U56_RS06815	COG4479	Belongs to the UPF0346 family
B4U56_RS06820	COG0793	Belongs to the peptidase S41A family
B4U56_RS06835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U56_RS06840	COG0671	phosphoesterase, PA-phosphatase related
B4U56_RS06850	COG0745	RESPONSE REGULATOR receiver
B4U56_RS06855	COG5002	protein histidine kinase activity
B4U56_RS06865	COG0567	Dehydrogenase, E1 component
B4U56_RS06870	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U56_RS06890	COG0714	Associated with various cellular activities
B4U56_RS06895	COG4548	von Willebrand factor, type A
B4U56_RS06900	COG1114	Component of the transport system for branched-chain amino acids
B4U56_RS06905	COG3853	Toxic anion resistance protein (TelA)
B4U56_RS06915	COG1254	Belongs to the acylphosphatase family
B4U56_RS06925	COG1278	Cold shock
B4U56_RS06940	COG1131	(ABC) transporter
B4U56_RS06960	COG1473	amidohydrolase
B4U56_RS06965	COG2171	N-acyltransferase activity
B4U56_RS06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4U56_RS06975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U56_RS06980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4U56_RS06985	COG0527	aspartate kinase activity
B4U56_RS06990	COG0488	(ABC) transporter
B4U56_RS06995	COG2996	Protein conserved in bacteria
B4U56_RS07000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U56_RS07005	COG0573	inorganic phosphate transmembrane transporter activity
B4U56_RS07010	COG0581	inorganic phosphate transmembrane transporter activity
B4U56_RS07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U56_RS07020	COG0704	Plays a role in the regulation of phosphate uptake
B4U56_RS07055	COG4607	ABC-type enterochelin transport system periplasmic component
B4U56_RS07065	COG2348	transferase activity, transferring amino-acyl groups
B4U56_RS07070	COG2348	transferase activity, transferring amino-acyl groups
B4U56_RS07085	COG0159	tryptophan synthase activity
B4U56_RS07090	COG0133	tryptophan synthase activity
B4U56_RS07095	COG0135	phosphoribosylanthranilate isomerase activity
B4U56_RS07100	COG0134	indole-3-glycerol-phosphate synthase activity
B4U56_RS07105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U56_RS07110	COG0512	Glutamine amidotransferase of anthranilate synthase
B4U56_RS07110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U56_RS07115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U56_RS07120	COG0287	Prephenate dehydrogenase
B4U56_RS07125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U56_RS07130	COG1942	4-Oxalocrotonate Tautomerase
B4U56_RS07150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4U56_RS07150	COG0392	lysyltransferase activity
B4U56_RS07155	COG0628	permease
B4U56_RS07160	COG3711	transcriptional antiterminator
B4U56_RS07165	COG1115	amino acid carrier protein
B4U56_RS07170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U56_RS07175	COG0187	DNA topoisomerase II activity
B4U56_RS07180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4U56_RS07185	COG4841	protein insertion into membrane
B4U56_RS07190	COG0824	Thioesterase
B4U56_RS07195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4U56_RS07200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U56_RS07205	COG1970	mechanosensitive ion channel activity
B4U56_RS07210	COG0419	ATPase involved in DNA repair
B4U56_RS07215	COG0420	3'-5' exonuclease activity
B4U56_RS07220	COG4846	Membrane protein involved in cytochrome C biogenesis
B4U56_RS07230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4U56_RS07235	COG4224	UPF0291 protein
B4U56_RS07245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U56_RS07255	COG2340	Cysteine-rich secretory protein family
B4U56_RS07260	COG0516	GMP reductase activity
B4U56_RS07265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U56_RS07275	COG0753	catalase activity
B4U56_RS07280	COG0833	amino acid
B4U56_RS07300	COG0083	homoserine kinase activity
B4U56_RS07305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4U56_RS07310	COG0460	homoserine dehydrogenase
B4U56_RS07315	COG0527	aspartate kinase activity
B4U56_RS07335	COG1525	nuclease
B4U56_RS07345	COG2197	response regulator
B4U56_RS07350	COG4585	Histidine kinase
B4U56_RS07360	COG1131	(ABC) transporter
B4U56_RS07365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U56_RS07410	COG0174	glutamine synthetase
B4U56_RS07415	COG0789	Transcriptional regulator
B4U56_RS07420	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4U56_RS07425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4U56_RS07430	COG0386	Belongs to the glutathione peroxidase family
B4U56_RS07435	COG1923	regulation of RNA biosynthetic process
B4U56_RS07440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4U56_RS07450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U56_RS07455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U56_RS07460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4U56_RS07465	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4U56_RS07470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4U56_RS07475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4U56_RS07485	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4U56_RS07490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U56_RS07500	COG4195	phage-related replication protein
B4U56_RS07505	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4U56_RS07510	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4U56_RS07510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4U56_RS07515	COG1692	metallophosphoesterase
B4U56_RS07525	COG1418	mRNA catabolic process
B4U56_RS07530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4U56_RS07535	COG1058	Belongs to the CinA family
B4U56_RS07535	COG1546	Belongs to the CinA family
B4U56_RS07540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U56_RS07555	COG0300	oxidoreductase activity
B4U56_RS07560	COG0612	Peptidase, M16
B4U56_RS07565	COG0612	Peptidase, M16
B4U56_RS07570	COG2188	Transcriptional regulator
B4U56_RS07575	COG1674	ftsk spoiiie
B4U56_RS07580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U56_RS07585	COG1185	polyribonucleotide nucleotidyltransferase activity
B4U56_RS07590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4U56_RS07595	COG0196	riboflavin kinase activity
B4U56_RS07600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4U56_RS07605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4U56_RS07610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4U56_RS07615	COG1358	cellular component organization or biogenesis
B4U56_RS07620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4U56_RS07625	COG0195	Participates in both transcription termination and antitermination
B4U56_RS07630	COG0779	Required for maturation of 30S ribosomal subunits
B4U56_RS07635	COG2176	DNA-directed DNA polymerase activity
B4U56_RS07640	COG0442	prolyl-tRNA aminoacylation
B4U56_RS07650	COG4589	Belongs to the CDS family
B4U56_RS07655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4U56_RS07660	COG0233	cytoplasmic translational termination
B4U56_RS07665	COG0528	UMP kinase activity
B4U56_RS07670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4U56_RS07675	COG0052	Belongs to the universal ribosomal protein uS2 family
B4U56_RS07680	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4U56_RS07685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4U56_RS07690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4U56_RS07695	COG4974	Belongs to the 'phage' integrase family
B4U56_RS07700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4U56_RS07705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U56_RS07710	COG0758	DNA mediated transformation
B4U56_RS07720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4U56_RS07725	COG0045	succinate-CoA ligase (ADP-forming) activity
B4U56_RS07730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U56_RS07745	COG4485	Bacterial membrane protein, YfhO
B4U56_RS07755	COG0335	large ribosomal subunit rRNA binding
B4U56_RS07760	COG0336	Belongs to the RNA methyltransferase TrmD family
B4U56_RS07765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4U56_RS07770	COG0228	four-way junction DNA binding
B4U56_RS07775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4U56_RS07780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4U56_RS07785	COG0552	protein localization to endoplasmic reticulum
B4U56_RS07790	COG1196	nuclear chromosome segregation
B4U56_RS07795	COG0571	ribonuclease III activity
B4U56_RS07800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U56_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
B4U56_RS07815	COG0416	fatty acid biosynthetic process
B4U56_RS07820	COG1349	DNA-binding transcription factor activity
B4U56_RS07825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4U56_RS07830	COG1461	Dihydroxyacetone kinase
B4U56_RS07835	COG1302	Protein conserved in bacteria
B4U56_RS07840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4U56_RS07850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4U56_RS07855	COG1162	GTPase activity
B4U56_RS07865	COG0631	protein serine/threonine phosphatase activity
B4U56_RS07870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4U56_RS07875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U56_RS07875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4U56_RS07880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U56_RS07885	COG0242	peptide deformylase activity
B4U56_RS07895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4U56_RS07900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U56_RS07905	COG1758	RNA polymerase activity
B4U56_RS07910	COG0194	GDP metabolic process
B4U56_RS07930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4U56_RS07935	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U56_RS07940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U56_RS07945	COG0505	Belongs to the CarA family
B4U56_RS07950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U56_RS07955	COG0540	Belongs to the ATCase OTCase family
B4U56_RS07960	COG2233	PERMEase
B4U56_RS07970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4U56_RS07975	COG0564	pseudouridine synthase activity
B4U56_RS07980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4U56_RS07985	COG3942	CHAP domain
B4U56_RS07985	COG1388	LysM domain
B4U56_RS07995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B4U56_RS08000	COG3599	regulation of cell shape
B4U56_RS08010	COG0762	integral membrane protein
B4U56_RS08015	COG1799	cell septum assembly
B4U56_RS08020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4U56_RS08025	COG1496	oxidoreductase activity
B4U56_RS08030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4U56_RS08035	COG0849	cell division
B4U56_RS08040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4U56_RS08045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U56_RS08050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U56_RS08055	COG0768	penicillin binding
B4U56_RS08060	COG4839	cell division protein FtsL
B4U56_RS08065	COG0275	rRNA processing
B4U56_RS08070	COG2001	Belongs to the MraZ family
B4U56_RS08075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4U56_RS08080	COG0454	-acetyltransferase
B4U56_RS08085	COG1011	Hydrolase
B4U56_RS08115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4U56_RS08120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4U56_RS08125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U56_RS08130	COG1053	succinate dehydrogenase
B4U56_RS08135	COG2009	succinate dehydrogenase
B4U56_RS08145	COG0322	excinuclease ABC activity
B4U56_RS08150	COG3118	belongs to the thioredoxin family
B4U56_RS08155	COG1193	negative regulation of DNA recombination
B4U56_RS08160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U56_RS08160	COG1796	DNA polymerase
B4U56_RS08170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4U56_RS08175	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U56_RS08180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U56_RS08180	COG0072	phenylalanine-tRNA ligase activity
B4U56_RS08185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4U56_RS08190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U56_RS08205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B4U56_RS08220	COG1323	Belongs to the UPF0348 family
B4U56_RS08225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4U56_RS08230	COG0742	ribosomal rna small subunit methyltransferase
B4U56_RS08240	COG4471	UPF0298 protein
B4U56_RS08250	COG0584	glycerophosphoryl diester phosphodiesterase
B4U56_RS08255	COG3679	Belongs to the UPF0342 family
B4U56_RS08260	COG2340	Cysteine-rich secretory protein family
B4U56_RS08270	COG0109	protoheme IX farnesyltransferase activity
B4U56_RS08275	COG1612	heme a metabolic process
B4U56_RS08285	COG0772	Belongs to the SEDS family
B4U56_RS08290	COG4838	Belongs to the UPF0358 family
B4U56_RS08295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U56_RS08300	COG4896	Protein conserved in bacteria
B4U56_RS08310	COG1217	gtp-binding protein TYPA
B4U56_RS08320	COG0483	inositol monophosphate 1-phosphatase activity
B4U56_RS08325	COG4493	Belongs to the UPF0637 family
B4U56_RS08330	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U56_RS08355	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4U56_RS08360	COG3842	ATPase activity
B4U56_RS08370	COG4476	Belongs to the UPF0223 family
B4U56_RS08380	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U56_RS08385	COG0022	dehydrogenase e1 component
B4U56_RS08390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U56_RS08400	COG0242	peptide deformylase activity
B4U56_RS08405	COG5503	Protein of unknown function (DUF1447)
B4U56_RS08410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U56_RS08415	COG0569	domain protein
B4U56_RS08420	COG1294	oxidase, subunit
B4U56_RS08425	COG1271	oxidase subunit
B4U56_RS08435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U56_RS08440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U56_RS08450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4U56_RS08465	COG4716	Myosin-crossreactive antigen
B4U56_RS08475	COG4172	Belongs to the ABC transporter superfamily
B4U56_RS08480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4U56_RS08485	COG0151	Belongs to the GarS family
B4U56_RS08490	COG0138	bifunctional purine biosynthesis protein purh
B4U56_RS08495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4U56_RS08500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4U56_RS08505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4U56_RS08510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U56_RS08515	COG0047	phosphoribosylformylglycinamidine synthase activity
B4U56_RS08520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U56_RS08525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4U56_RS08530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4U56_RS08535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4U56_RS08540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U56_RS08550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U56_RS08555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U56_RS08560	COG1845	cytochrome c oxidase, subunit III
B4U56_RS08565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4U56_RS08580	COG1316	TRANSCRIPTIONal
B4U56_RS08605	COG3594	Acyltransferase
B4U56_RS08610	COG0436	Aminotransferase
B4U56_RS08615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4U56_RS08625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4U56_RS08630	COG1169	isochorismate synthase
B4U56_RS08640	COG1575	Belongs to the MenA family. Type 1 subfamily
B4U56_RS08650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U56_RS08660	COG2314	TM2 domain
B4U56_RS08710	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U56_RS08710	COG1388	LysM domain
B4U56_RS08735	COG4195	phage-related replication protein
B4U56_RS08850	COG0756	dUTP diphosphatase activity
B4U56_RS08995	COG4873	Protein conserved in bacteria
B4U56_RS09005	COG0737	Belongs to the 5'-nucleotidase family
B4U56_RS09010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U56_RS09015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U56_RS09020	COG0861	Integral membrane protein TerC family
B4U56_RS09025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B4U56_RS09035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U56_RS09040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U56_RS09045	COG2814	Major facilitator Superfamily
B4U56_RS09050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4U56_RS09055	COG2382	esterase
B4U56_RS09060	COG0628	permease
B4U56_RS09120	COG0475	glutathione-regulated potassium exporter activity
B4U56_RS09120	COG0569	domain protein
B4U56_RS09125	COG2239	Acts as a magnesium transporter
B4U56_RS09130	COG0564	pseudouridine synthase activity
B4U56_RS09135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U56_RS09140	COG2357	RelA SpoT domain protein
B4U56_RS09155	COG2346	COG2346, Truncated hemoglobins
B4U56_RS09160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U56_RS09165	COG1164	Oligoendopeptidase f
B4U56_RS09175	COG4862	establishment of competence for transformation
B4U56_RS09185	COG1393	Belongs to the ArsC family
B4U56_RS09190	COG0180	Tryptophanyl-tRNA synthetase
B4U56_RS09195	COG4166	transmembrane transport
B4U56_RS09200	COG4608	Belongs to the ABC transporter superfamily
B4U56_RS09205	COG0444	Belongs to the ABC transporter superfamily
B4U56_RS09210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U56_RS09215	COG0601	transmembrane transport
B4U56_RS09230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U56_RS09245	COG0542	response to heat
B4U56_RS09260	COG0561	phosphatase activity
B4U56_RS09265	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U56_RS09285	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U56_RS09290	COG1074	ATP-dependent DNA helicase activity
B4U56_RS09295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4U56_RS09310	COG0398	Pfam SNARE associated Golgi protein
B4U56_RS09315	COG0166	Belongs to the GPI family
B4U56_RS09320	COG0137	argininosuccinate synthase activity
B4U56_RS09325	COG0165	Argininosuccinate lyase
B4U56_RS09330	COG0584	glycerophosphoryl diester phosphodiesterase
B4U56_RS09340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U56_RS09350	COG1902	pentaerythritol trinitrate reductase activity
B4U56_RS09355	COG1098	S1 RNA binding domain
B4U56_RS09360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U56_RS09370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U56_RS09370	COG2111	Na H antiporter
B4U56_RS09375	COG2111	Na H antiporter
B4U56_RS09380	COG1006	Multisubunit Na H antiporter MnhC subunit
B4U56_RS09385	COG0651	ATP synthesis coupled electron transport
B4U56_RS09390	COG1863	multisubunit Na H antiporter MnhE subunit
B4U56_RS09395	COG2212	antiporter activity
B4U56_RS09400	COG1320	monovalent cation:proton antiporter activity
B4U56_RS09410	COG2050	protein possibly involved in aromatic compounds catabolism
B4U56_RS09415	COG2056	Na+-H+ antiporter family
B4U56_RS09420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4U56_RS09425	COG1252	NADH dehydrogenase
B4U56_RS09430	COG0316	Belongs to the HesB IscA family
B4U56_RS09435	COG4844	belongs to the
B4U56_RS09440	COG1252	NADH dehydrogenase
B4U56_RS09445	COG4837	Protein of unknown function (DUF1462)
B4U56_RS09450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4U56_RS09460	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4U56_RS09465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U56_RS09470	COG1696	Membrane protein involved in D-alanine export
B4U56_RS09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U56_RS09485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U56_RS09490	COG0647	UMP catabolic process
B4U56_RS09495	COG2445	Protein of unknown function DUF86
B4U56_RS09505	COG4470	Protein conserved in bacteria
B4U56_RS09510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4U56_RS09515	COG0737	Belongs to the 5'-nucleotidase family
B4U56_RS09520	COG0730	response to heat
B4U56_RS09525	COG1801	Protein of unknown function DUF72
B4U56_RS09530	COG1253	flavin adenine dinucleotide binding
B4U56_RS09540	COG0719	Fe-S assembly protein
B4U56_RS09545	COG0822	iron-sulfur transferase activity
B4U56_RS09550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U56_RS09555	COG0719	Fe-S assembly protein
B4U56_RS09560	COG0396	ATPase activity
B4U56_RS09570	COG3237	CsbD-like
B4U56_RS09580	COG1464	Belongs to the NlpA lipoprotein family
B4U56_RS09585	COG2011	ABC-type metal ion transport system permease component
B4U56_RS09590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U56_RS09600	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U56_RS09610	COG0509	glycine decarboxylation via glycine cleavage system
B4U56_RS09615	COG1393	Belongs to the ArsC family
B4U56_RS09620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U56_RS09630	COG0710	3-dehydroquinate dehydratase activity
B4U56_RS09635	COG1764	response to oxidative stress
B4U56_RS09690	COG4195	phage-related replication protein
B4U56_RS09705	COG1278	Cold shock
B4U56_RS09740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U56_RS09775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4U56_RS09780	COG0557	exoribonuclease II activity
B4U56_RS09785	COG1647	Serine aminopeptidase, S33
B4U56_RS09790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U56_RS09800	COG0148	phosphopyruvate hydratase activity
B4U56_RS09805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4U56_RS09810	COG0149	triose-phosphate isomerase activity
B4U56_RS09815	COG0126	phosphoglycerate kinase activity
B4U56_RS09820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U56_RS09840	COG1090	epimerase
B4U56_RS09850	COG0740	serine-type endopeptidase activity
B4U56_RS09860	COG1481	regulation of sporulation
B4U56_RS09865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4U56_RS09870	COG1660	Displays ATPase and GTPase activities
B4U56_RS09875	COG0492	ferredoxin-NADP+ reductase activity
B4U56_RS09890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4U56_RS09895	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4U56_RS09900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U56_RS09905	COG0556	nucleotide-excision repair
B4U56_RS09925	COG1388	LysM domain
B4U56_RS09925	COG3942	CHAP domain
B4U56_RS09930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4U56_RS09935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4U56_RS09940	COG0653	protein targeting
B4U56_RS09945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4U56_RS09950	COG1040	competence protein
B4U56_RS09955	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4U56_RS09965	COG1739	Uncharacterized protein family UPF0029
B4U56_RS09970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U56_RS09975	COG2199	diguanylate cyclase activity
B4U56_RS09990	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U56_RS09995	COG1929	Belongs to the glycerate kinase type-1 family
B4U56_RS10015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4U56_RS10030	COG4604	ABC transporter, ATP-binding protein
B4U56_RS10035	COG4605	iron ion homeostasis
B4U56_RS10040	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U56_RS10050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U56_RS10055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U56_RS10060	COG1780	Probably involved in ribonucleotide reductase function
B4U56_RS10070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4U56_RS10075	COG3104	oligopeptide transport
B4U56_RS10085	COG1597	lipid kinase activity
B4U56_RS10090	COG1454	alcohol dehydrogenase
B4U56_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
B4U56_RS10095	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B4U56_RS10100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U56_RS10105	COG1174	glycine betaine transport
B4U56_RS10115	COG0514	ATP-dependent DNA helicase (RecQ)
B4U56_RS10120	COG0488	(ABC) transporter
B4U56_RS10130	COG1368	sulfuric ester hydrolase activity
B4U56_RS10140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U56_RS10155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U56_RS10165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4U56_RS10170	COG0720	synthase
B4U56_RS10175	COG0602	queuosine metabolic process
B4U56_RS10200	COG0745	RESPONSE REGULATOR receiver
B4U56_RS10205	COG5002	protein histidine kinase activity
B4U56_RS10210	COG0463	Glycosyl transferase, family 2
B4U56_RS10215	COG0656	L-ascorbic acid biosynthetic process
B4U56_RS10220	COG1253	flavin adenine dinucleotide binding
B4U56_RS10225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U56_RS10230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U56_RS10230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U56_RS10230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U56_RS10235	COG1105	Belongs to the carbohydrate kinase PfkB family
B4U56_RS10240	COG1349	DNA-binding transcription factor activity
B4U56_RS10250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4U56_RS10275	COG0415	Belongs to the DNA photolyase family
B4U56_RS10280	COG0471	metal ion transport
B4U56_RS10285	COG0039	L-malate dehydrogenase activity
B4U56_RS10310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4U56_RS10315	COG4988	ABC transporter
B4U56_RS10320	COG1968	undecaprenyl-diphosphatase activity
B4U56_RS10335	COG1671	Belongs to the UPF0178 family
B4U56_RS10340	COG1611	Belongs to the LOG family
B4U56_RS10365	COG2839	Protein conserved in bacteria
B4U56_RS10370	COG2814	Major facilitator Superfamily
B4U56_RS10375	COG0583	DNA-binding transcription factor activity
B4U56_RS10395	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B4U56_RS10410	COG0217	transcriptional regulatory protein
B4U56_RS10430	COG3942	CHAP domain
B4U56_RS10430	COG1388	LysM domain
B4U56_RS10435	COG0306	phosphate transporter
B4U56_RS10440	COG1392	Phosphate transport regulator
B4U56_RS10445	COG0577	efflux transmembrane transporter activity
B4U56_RS10450	COG1136	(ABC) transporter
B4U56_RS10455	COG2205	protein histidine kinase activity
B4U56_RS10460	COG0745	RESPONSE REGULATOR receiver
B4U56_RS10465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U56_RS10480	COG3949	Membrane
B4U56_RS10490	COG1120	ATPase activity
B4U56_RS10495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U56_RS10500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U56_RS10505	COG1132	(ABC) transporter
B4U56_RS10520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4U56_RS10530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U56_RS10535	COG1682	transport, permease protein
B4U56_RS10540	COG1134	teichoic acid transport
B4U56_RS10545	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4U56_RS10555	COG1321	iron dependent repressor
B4U56_RS10560	COG1121	(ABC) transporter
B4U56_RS10565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U56_RS10570	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U56_RS10580	COG1320	monovalent cation:proton antiporter activity
B4U56_RS10585	COG2212	antiporter activity
B4U56_RS10590	COG1863	multisubunit Na H antiporter MnhE subunit
B4U56_RS10595	COG0651	ATP synthesis coupled electron transport
B4U56_RS10600	COG1006	Multisubunit Na H antiporter MnhC subunit
B4U56_RS10605	COG2111	Na H antiporter
B4U56_RS10610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U56_RS10610	COG2111	Na H antiporter
B4U56_RS10650	COG0596	Alpha beta hydrolase
B4U56_RS10670	COG0546	phosphoglycolate phosphatase activity
B4U56_RS10675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U56_RS10680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U56_RS10695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4U56_RS10700	COG0018	arginyl-trna synthetase
B4U56_RS10720	COG1064	alcohol dehydrogenase
B4U56_RS10725	COG3875	lactate racemase activity
B4U56_RS10730	COG1606	tRNA processing
B4U56_RS10735	COG1691	(AIR) carboxylase
B4U56_RS10740	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B4U56_RS10750	COG1078	dGTPase activity
B4U56_RS10760	COG0667	Aldo Keto reductase
B4U56_RS10770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U56_RS10775	COG4844	belongs to the
B4U56_RS10795	COG0095	Lipoate-protein ligase
B4U56_RS10800	COG0280	phosphate acetyltransferase
B4U56_RS10805	COG3253	May function as heme-dependent peroxidase
B4U56_RS10820	COG0531	amino acid
B4U56_RS10825	COG2363	Small membrane protein
B4U56_RS10835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U56_RS10845	COG0351	phosphomethylpyrimidine kinase
B4U56_RS10870	COG0183	Belongs to the thiolase family
B4U56_RS10875	COG0318	PFAM AMP-dependent synthetase and ligase
B4U56_RS10885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4U56_RS10890	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4U56_RS10895	COG0363	glucosamine-6-phosphate deaminase activity
B4U56_RS10905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U56_RS10910	COG1469	GTP cyclohydrolase I activity
B4U56_RS10915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U56_RS10920	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U56_RS10925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U56_RS10940	COG0431	NADPH-dependent FMN reductase
B4U56_RS10945	COG0561	phosphatase activity
B4U56_RS10955	COG1428	Deoxynucleoside kinase
B4U56_RS10960	COG1428	Deoxynucleoside kinase
B4U56_RS10970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U56_RS10975	COG0546	phosphoglycolate phosphatase activity
B4U56_RS10980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U56_RS10985	COG1063	alcohol dehydrogenase
B4U56_RS10990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4U56_RS10995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U56_RS11000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U56_RS11020	COG1473	amidohydrolase
B4U56_RS11025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U56_RS11030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U56_RS11040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4U56_RS11050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4U56_RS11055	COG0085	RNA polymerase activity
B4U56_RS11060	COG2813	Specifically methylates the guanine in position
B4U56_RS11065	COG0222	ribosome binding
B4U56_RS11070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4U56_RS11080	COG0081	regulation of translation
B4U56_RS11085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B4U56_RS11090	COG0250	Participates in transcription elongation, termination and antitermination
B4U56_RS11095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U56_RS11100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U56_RS11110	COG3688	RNA-binding protein containing a PIN domain
B4U56_RS11115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U56_RS11120	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4U56_RS11125	COG0215	cysteine-tRNA ligase activity
B4U56_RS11130	COG1045	serine acetyltransferase
B4U56_RS11135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4U56_RS11140	COG4956	integral membrane protein (PIN domain superfamily)
B4U56_RS11145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4U56_RS11150	COG0542	response to heat
B4U56_RS11155	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4U56_RS11160	COG3880	PFAM UvrB UvrC protein
B4U56_RS11165	COG4463	regulation of RNA biosynthetic process
B4U56_RS11170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U56_RS11180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4U56_RS11185	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B4U56_RS11190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U56_RS11275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U56_RS11280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4U56_RS11285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4U56_RS11290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4U56_RS11295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U56_RS11300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4U56_RS11305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U56_RS11310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4U56_RS11315	COG0037	tRNA processing
B4U56_RS11320	COG1098	S1 RNA binding domain
B4U56_RS11330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4U56_RS11335	COG3956	TIGRFAM MazG family protein
B4U56_RS11340	COG2244	polysaccharide biosynthetic process
B4U56_RS11345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4U56_RS11350	COG0193	aminoacyl-tRNA hydrolase activity
B4U56_RS11355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4U56_RS11360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4U56_RS11365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4U56_RS11370	COG2088	sporulation resulting in formation of a cellular spore
B4U56_RS11375	COG0251	oxidation-reduction process
B4U56_RS11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U56_RS11385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4U56_RS11390	COG4466	Protein conserved in bacteria
B4U56_RS11395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4U56_RS11400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U56_RS11405	COG0084	hydrolase, TatD family'
B4U56_RS11410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U56_RS11410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U56_RS11415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4U56_RS11420	COG2827	Endonuclease containing a URI domain
B4U56_RS11425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4U56_RS11430	COG4467	Involved in initiation control of chromosome replication
B4U56_RS11435	COG1774	PSP1 C-terminal conserved region
B4U56_RS11440	COG0470	DNA polymerase III
B4U56_RS11445	COG3870	Protein conserved in bacteria
B4U56_RS11450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4U56_RS11455	COG1982	Orn Lys Arg decarboxylase major
B4U56_RS11480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4U56_RS11485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4U56_RS11490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4U56_RS11505	COG2855	membrane
B4U56_RS11510	COG0583	DNA-binding transcription factor activity
B4U56_RS11520	COG0493	'glutamate synthase
B4U56_RS11525	COG0069	glutamate synthase activity
B4U56_RS11525	COG0070	glutamate synthase
B4U56_RS11525	COG0067	glutamate synthase
B4U56_RS11530	COG0583	DNA-binding transcription factor activity
B4U56_RS11560	COG0438	transferase activity, transferring glycosyl groups
B4U56_RS11565	COG3942	CHAP domain
B4U56_RS11565	COG1388	LysM domain
B4U56_RS11575	COG2011	ABC-type metal ion transport system permease component
B4U56_RS11580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U56_RS11585	COG0626	cystathionine gamma-synthase activity
B4U56_RS11590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U56_RS11600	COG0733	neurotransmitter:sodium symporter activity
B4U56_RS11610	COG1647	Serine aminopeptidase, S33
B4U56_RS11625	COG5609	conserved protein (DUF2294)
B4U56_RS11630	COG3002	Belongs to the UPF0753 family
B4U56_RS11635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U56_RS11655	COG0523	cobalamin synthesis protein
B4U56_RS11670	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U56_RS11710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4U56_RS11710	COG0519	Catalyzes the synthesis of GMP from XMP
B4U56_RS11715	COG0517	IMP dehydrogenase activity
B4U56_RS11715	COG0516	GMP reductase activity
B4U56_RS11720	COG2233	PERMEase
B4U56_RS11725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U56_RS11740	COG5183	chlorophyll binding
B4U56_RS11750	COG1823	symporter activity
B4U56_RS11755	COG0778	Nitroreductase
B4U56_RS11765	COG0450	alkyl hydroperoxide reductase
B4U56_RS11770	COG3634	alkyl hydroperoxide reductase activity
B4U56_RS11805	COG1280	lysine exporter protein (LysE YggA)
B4U56_RS11830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4U56_RS11840	COG0360	Binds together with S18 to 16S ribosomal RNA
B4U56_RS11855	COG0012	GTP binding
B4U56_RS11860	COG4481	Protein conserved in bacteria
B4U56_RS11865	COG0668	transmembrane transport
B4U56_RS11870	COG1475	DNA binding
B4U56_RS11880	COG0626	cystathionine gamma-synthase activity
B4U56_RS11885	COG0626	cystathionine gamma-synthase activity
B4U56_RS11890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4U56_RS11890	COG0646	methionine synthase
B4U56_RS11895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4U56_RS11905	COG0183	Belongs to the thiolase family
B4U56_RS11920	COG1476	TRANSCRIPTIONal
B4U56_RS11930	COG4555	ABC transporter
B4U56_RS11950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U56_RS11960	COG0583	DNA-binding transcription factor activity
B4U56_RS11995	COG4932	domain protein
B4U56_RS11995	COG3266	domain, Protein
B4U56_RS11995	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B4U56_RS12020	COG1136	(ABC) transporter
B4U56_RS12025	COG0577	efflux transmembrane transporter activity
B4U56_RS12045	COG0577	efflux transmembrane transporter activity
B4U56_RS12050	COG1136	(ABC) transporter
B4U56_RS12090	COG1475	DNA binding
B4U56_RS12095	COG0357	Ribosomal RNA small subunit methyltransferase G
B4U56_RS12100	COG0445	tRNA wobble uridine modification
B4U56_RS12105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4U56_RS12110	COG0594	ribonuclease P activity