locus-tag	class	description
KB226_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KB226_RS00010	COG0592	DNA-directed DNA polymerase activity
KB226_RS00015	COG2501	S4 domain
KB226_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KB226_RS00025	COG0187	DNA topoisomerase II activity
KB226_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KB226_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KB226_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KB226_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KB226_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KB226_RS00075	COG0359	binds to the 23S rRNA
KB226_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
KB226_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KB226_RS00100	COG0745	RESPONSE REGULATOR receiver
KB226_RS00105	COG5002	protein histidine kinase activity
KB226_RS00110	COG4863	YycH protein
KB226_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KB226_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KB226_RS00155	COG0183	Belongs to the thiolase family
KB226_RS00170	COG1476	TRANSCRIPTIONal
KB226_RS00190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KB226_RS00195	COG0646	methionine synthase
KB226_RS00195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KB226_RS00200	COG0626	cystathionine gamma-synthase activity
KB226_RS00205	COG0626	cystathionine gamma-synthase activity
KB226_RS00210	COG1475	DNA binding
KB226_RS00215	COG0668	transmembrane transport
KB226_RS00220	COG4481	Protein conserved in bacteria
KB226_RS00225	COG0012	GTP binding
KB226_RS00240	COG0360	Binds together with S18 to 16S ribosomal RNA
KB226_RS00250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KB226_RS00270	COG1280	lysine exporter protein (LysE YggA)
KB226_RS00290	COG3634	alkyl hydroperoxide reductase activity
KB226_RS00295	COG0450	alkyl hydroperoxide reductase
KB226_RS00305	COG0778	Nitroreductase
KB226_RS00310	COG1823	symporter activity
KB226_RS00315	COG5183	chlorophyll binding
KB226_RS00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KB226_RS00335	COG2233	PERMEase
KB226_RS00340	COG0516	GMP reductase activity
KB226_RS00340	COG0517	IMP dehydrogenase activity
KB226_RS00345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KB226_RS00345	COG0519	Catalyzes the synthesis of GMP from XMP
KB226_RS00395	COG0523	cobalamin synthesis protein
KB226_RS00410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KB226_RS00415	COG3002	Belongs to the UPF0753 family
KB226_RS00420	COG5609	conserved protein (DUF2294)
KB226_RS00435	COG1647	Serine aminopeptidase, S33
KB226_RS00445	COG0733	neurotransmitter:sodium symporter activity
KB226_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KB226_RS00460	COG0626	cystathionine gamma-synthase activity
KB226_RS00465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KB226_RS00470	COG2011	ABC-type metal ion transport system permease component
KB226_RS00480	COG1388	LysM domain
KB226_RS00480	COG3942	CHAP domain
KB226_RS00485	COG0438	transferase activity, transferring glycosyl groups
KB226_RS00510	COG0583	DNA-binding transcription factor activity
KB226_RS00515	COG0067	glutamate synthase
KB226_RS00515	COG0069	glutamate synthase activity
KB226_RS00515	COG0070	glutamate synthase
KB226_RS00520	COG0493	'glutamate synthase
KB226_RS00530	COG0583	DNA-binding transcription factor activity
KB226_RS00535	COG2855	membrane
KB226_RS00555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KB226_RS00560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KB226_RS00565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KB226_RS00590	COG1982	Orn Lys Arg decarboxylase major
KB226_RS00595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KB226_RS00600	COG3870	Protein conserved in bacteria
KB226_RS00605	COG0470	DNA polymerase III
KB226_RS00610	COG1774	PSP1 C-terminal conserved region
KB226_RS00615	COG4467	Involved in initiation control of chromosome replication
KB226_RS00620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KB226_RS00625	COG2827	Endonuclease containing a URI domain
KB226_RS00630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KB226_RS00635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KB226_RS00635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KB226_RS00640	COG0084	hydrolase, TatD family'
KB226_RS00645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KB226_RS00650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KB226_RS00655	COG4466	Protein conserved in bacteria
KB226_RS00660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KB226_RS00665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KB226_RS00670	COG0251	oxidation-reduction process
KB226_RS00675	COG2088	sporulation resulting in formation of a cellular spore
KB226_RS00680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KB226_RS00685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KB226_RS00690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KB226_RS00695	COG0193	aminoacyl-tRNA hydrolase activity
KB226_RS00700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KB226_RS00705	COG2244	polysaccharide biosynthetic process
KB226_RS00710	COG3956	TIGRFAM MazG family protein
KB226_RS00715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KB226_RS00725	COG1098	S1 RNA binding domain
KB226_RS00730	COG0037	tRNA processing
KB226_RS00735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KB226_RS00740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KB226_RS00745	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KB226_RS00750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KB226_RS00755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KB226_RS00760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KB226_RS00765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KB226_RS00770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KB226_RS00880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KB226_RS00885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KB226_RS00890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KB226_RS00900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KB226_RS00905	COG4463	regulation of RNA biosynthetic process
KB226_RS00910	COG3880	PFAM UvrB UvrC protein
KB226_RS00915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KB226_RS00920	COG0542	response to heat
KB226_RS00925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KB226_RS00930	COG4956	integral membrane protein (PIN domain superfamily)
KB226_RS00935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KB226_RS00940	COG1045	serine acetyltransferase
KB226_RS00945	COG0215	cysteine-tRNA ligase activity
KB226_RS00950	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KB226_RS00955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KB226_RS00960	COG3688	RNA-binding protein containing a PIN domain
KB226_RS00970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KB226_RS00975	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KB226_RS00980	COG0250	Participates in transcription elongation, termination and antitermination
KB226_RS00985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KB226_RS00990	COG0081	regulation of translation
KB226_RS00995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KB226_RS01000	COG0222	ribosome binding
KB226_RS01005	COG2813	Specifically methylates the guanine in position
KB226_RS01010	COG0085	RNA polymerase activity
KB226_RS01015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KB226_RS01025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KB226_RS01035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KB226_RS01040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KB226_RS01045	COG1473	amidohydrolase
KB226_RS01065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KB226_RS01070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KB226_RS01075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KB226_RS01080	COG1063	alcohol dehydrogenase
KB226_RS01085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KB226_RS01090	COG0546	phosphoglycolate phosphatase activity
KB226_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS01105	COG1428	Deoxynucleoside kinase
KB226_RS01110	COG1428	Deoxynucleoside kinase
KB226_RS01120	COG0561	phosphatase activity
KB226_RS01125	COG0431	NADPH-dependent FMN reductase
KB226_RS01150	COG1469	GTP cyclohydrolase I activity
KB226_RS01155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KB226_RS01165	COG0363	glucosamine-6-phosphate deaminase activity
KB226_RS01170	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KB226_RS01175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KB226_RS01190	COG0183	Belongs to the thiolase family
KB226_RS01210	COG0351	phosphomethylpyrimidine kinase
KB226_RS01220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KB226_RS01230	COG2363	Small membrane protein
KB226_RS01235	COG0531	amino acid
KB226_RS01255	COG3253	May function as heme-dependent peroxidase
KB226_RS01260	COG0280	phosphate acetyltransferase
KB226_RS01265	COG0095	Lipoate-protein ligase
KB226_RS01285	COG4844	belongs to the
KB226_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KB226_RS01300	COG0667	Aldo Keto reductase
KB226_RS01310	COG1078	dGTPase activity
KB226_RS01320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KB226_RS01325	COG1691	(AIR) carboxylase
KB226_RS01330	COG1606	tRNA processing
KB226_RS01340	COG1064	alcohol dehydrogenase
KB226_RS01355	COG0018	arginyl-trna synthetase
KB226_RS01360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KB226_RS01370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KB226_RS01375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KB226_RS01380	COG0546	phosphoglycolate phosphatase activity
KB226_RS01400	COG0596	Alpha beta hydrolase
KB226_RS01430	COG2111	Na H antiporter
KB226_RS01430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KB226_RS01435	COG2111	Na H antiporter
KB226_RS01440	COG1006	Multisubunit Na H antiporter MnhC subunit
KB226_RS01445	COG0651	ATP synthesis coupled electron transport
KB226_RS01450	COG1863	multisubunit Na H antiporter MnhE subunit
KB226_RS01455	COG2212	antiporter activity
KB226_RS01460	COG1320	monovalent cation:proton antiporter activity
KB226_RS01470	COG0803	Belongs to the bacterial solute-binding protein 9 family
KB226_RS01475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KB226_RS01480	COG1121	(ABC) transporter
KB226_RS01485	COG1321	iron dependent repressor
KB226_RS01495	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KB226_RS01500	COG1134	teichoic acid transport
KB226_RS01505	COG1682	transport, permease protein
KB226_RS01510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KB226_RS01520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KB226_RS01525	COG1132	(ABC) transporter
KB226_RS01530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KB226_RS01535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KB226_RS01540	COG1120	ATPase activity
KB226_RS01550	COG3949	Membrane
KB226_RS01565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KB226_RS01570	COG0745	RESPONSE REGULATOR receiver
KB226_RS01575	COG2205	protein histidine kinase activity
KB226_RS01580	COG1136	(ABC) transporter
KB226_RS01585	COG0577	efflux transmembrane transporter activity
KB226_RS01590	COG1392	Phosphate transport regulator
KB226_RS01595	COG0306	phosphate transporter
KB226_RS01600	COG3942	CHAP domain
KB226_RS01600	COG1388	LysM domain
KB226_RS01620	COG0217	transcriptional regulatory protein
KB226_RS01630	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KB226_RS01650	COG0583	DNA-binding transcription factor activity
KB226_RS01655	COG2814	Major facilitator Superfamily
KB226_RS01660	COG2839	Protein conserved in bacteria
KB226_RS01685	COG1611	Belongs to the LOG family
KB226_RS01690	COG1671	Belongs to the UPF0178 family
KB226_RS01705	COG1968	undecaprenyl-diphosphatase activity
KB226_RS01710	COG4988	ABC transporter
KB226_RS01715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KB226_RS01735	COG0039	L-malate dehydrogenase activity
KB226_RS01740	COG0471	metal ion transport
KB226_RS01745	COG0415	Belongs to the DNA photolyase family
KB226_RS01770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KB226_RS01775	COG1349	DNA-binding transcription factor activity
KB226_RS01780	COG1105	Belongs to the carbohydrate kinase PfkB family
KB226_RS01785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KB226_RS01785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KB226_RS01785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KB226_RS01790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KB226_RS01795	COG1253	flavin adenine dinucleotide binding
KB226_RS01800	COG0656	L-ascorbic acid biosynthetic process
KB226_RS01805	COG0463	Glycosyl transferase, family 2
KB226_RS01810	COG5002	protein histidine kinase activity
KB226_RS01815	COG0745	RESPONSE REGULATOR receiver
KB226_RS01840	COG0602	queuosine metabolic process
KB226_RS01845	COG0720	synthase
KB226_RS01850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KB226_RS01860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KB226_RS01875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KB226_RS01885	COG1368	sulfuric ester hydrolase activity
KB226_RS01900	COG0488	(ABC) transporter
KB226_RS01905	COG0514	ATP-dependent DNA helicase (RecQ)
KB226_RS01915	COG1174	glycine betaine transport
KB226_RS01920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KB226_RS01925	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
KB226_RS01930	COG1454	alcohol dehydrogenase
KB226_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS01935	COG1597	lipid kinase activity
KB226_RS01945	COG3104	oligopeptide transport
KB226_RS01950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KB226_RS01960	COG1780	Probably involved in ribonucleotide reductase function
KB226_RS01965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KB226_RS01970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KB226_RS01980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KB226_RS01985	COG4605	iron ion homeostasis
KB226_RS01990	COG4604	ABC transporter, ATP-binding protein
KB226_RS02005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KB226_RS02025	COG1929	Belongs to the glycerate kinase type-1 family
KB226_RS02030	COG2195	Cleaves the N-terminal amino acid of tripeptides
KB226_RS02045	COG2199	diguanylate cyclase activity
KB226_RS02050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KB226_RS02055	COG1739	Uncharacterized protein family UPF0029
KB226_RS02065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KB226_RS02070	COG1040	competence protein
KB226_RS02075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KB226_RS02080	COG0653	protein targeting
KB226_RS02090	COG3942	CHAP domain
KB226_RS02090	COG1388	LysM domain
KB226_RS02105	COG0556	nucleotide-excision repair
KB226_RS02110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KB226_RS02115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KB226_RS02120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KB226_RS02135	COG0492	ferredoxin-NADP+ reductase activity
KB226_RS02140	COG1660	Displays ATPase and GTPase activities
KB226_RS02145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KB226_RS02150	COG1481	regulation of sporulation
KB226_RS02160	COG0740	serine-type endopeptidase activity
KB226_RS02170	COG1090	epimerase
KB226_RS02190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KB226_RS02195	COG0126	phosphoglycerate kinase activity
KB226_RS02200	COG0149	triose-phosphate isomerase activity
KB226_RS02205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KB226_RS02210	COG0148	phosphopyruvate hydratase activity
KB226_RS02220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KB226_RS02225	COG1647	Serine aminopeptidase, S33
KB226_RS02230	COG0557	exoribonuclease II activity
KB226_RS02235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KB226_RS02275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KB226_RS02300	COG1278	Cold shock
KB226_RS02315	COG4195	phage-related replication protein
KB226_RS02370	COG1764	response to oxidative stress
KB226_RS02375	COG0710	3-dehydroquinate dehydratase activity
KB226_RS02385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KB226_RS02390	COG1393	Belongs to the ArsC family
KB226_RS02395	COG0509	glycine decarboxylation via glycine cleavage system
KB226_RS02400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KB226_RS02410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KB226_RS02415	COG2011	ABC-type metal ion transport system permease component
KB226_RS02420	COG1464	Belongs to the NlpA lipoprotein family
KB226_RS02430	COG3237	CsbD-like
KB226_RS02440	COG0396	ATPase activity
KB226_RS02445	COG0719	Fe-S assembly protein
KB226_RS02450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KB226_RS02455	COG0822	iron-sulfur transferase activity
KB226_RS02460	COG0719	Fe-S assembly protein
KB226_RS02465	COG4974	Belongs to the 'phage' integrase family
KB226_RS02480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KB226_RS02565	COG1484	DNA-dependent DNA replication
KB226_RS02605	COG0756	dUTP diphosphatase activity
KB226_RS02730	COG4195	phage-related replication protein
KB226_RS02790	COG1253	flavin adenine dinucleotide binding
KB226_RS02795	COG1801	Protein of unknown function DUF72
KB226_RS02800	COG0730	response to heat
KB226_RS02805	COG0737	Belongs to the 5'-nucleotidase family
KB226_RS02810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KB226_RS02815	COG4470	Protein conserved in bacteria
KB226_RS02825	COG2445	Protein of unknown function DUF86
KB226_RS02830	COG0647	UMP catabolic process
KB226_RS02835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KB226_RS02845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KB226_RS02850	COG1696	Membrane protein involved in D-alanine export
KB226_RS02855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KB226_RS02860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KB226_RS02865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KB226_RS02870	COG4837	Protein of unknown function (DUF1462)
KB226_RS02875	COG1252	NADH dehydrogenase
KB226_RS02880	COG4844	belongs to the
KB226_RS02885	COG0316	Belongs to the HesB IscA family
KB226_RS02890	COG1252	NADH dehydrogenase
KB226_RS02895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KB226_RS02900	COG2056	Na+-H+ antiporter family
KB226_RS02905	COG2050	protein possibly involved in aromatic compounds catabolism
KB226_RS02915	COG1320	monovalent cation:proton antiporter activity
KB226_RS02920	COG2212	antiporter activity
KB226_RS02925	COG1863	multisubunit Na H antiporter MnhE subunit
KB226_RS02930	COG0651	ATP synthesis coupled electron transport
KB226_RS02935	COG1006	Multisubunit Na H antiporter MnhC subunit
KB226_RS02940	COG2111	Na H antiporter
KB226_RS02945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KB226_RS02945	COG2111	Na H antiporter
KB226_RS02955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KB226_RS02960	COG1098	S1 RNA binding domain
KB226_RS02965	COG1902	pentaerythritol trinitrate reductase activity
KB226_RS02975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KB226_RS02985	COG0584	glycerophosphoryl diester phosphodiesterase
KB226_RS02990	COG0165	Argininosuccinate lyase
KB226_RS02995	COG0137	argininosuccinate synthase activity
KB226_RS03000	COG0166	Belongs to the GPI family
KB226_RS03005	COG0398	Pfam SNARE associated Golgi protein
KB226_RS03020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KB226_RS03025	COG1074	ATP-dependent DNA helicase activity
KB226_RS03030	COG0179	Fumarylacetoacetate (FAA) hydrolase
KB226_RS03050	COG0446	pyridine nucleotide-disulphide oxidoreductase
KB226_RS03055	COG0561	phosphatase activity
KB226_RS03070	COG0542	response to heat
KB226_RS03085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KB226_RS03100	COG0601	transmembrane transport
KB226_RS03105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KB226_RS03110	COG0444	Belongs to the ABC transporter superfamily
KB226_RS03115	COG4608	Belongs to the ABC transporter superfamily
KB226_RS03120	COG4166	transmembrane transport
KB226_RS03125	COG0180	Tryptophanyl-tRNA synthetase
KB226_RS03130	COG1393	Belongs to the ArsC family
KB226_RS03135	COG4862	establishment of competence for transformation
KB226_RS03145	COG1164	Oligoendopeptidase f
KB226_RS03150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KB226_RS03155	COG2346	COG2346, Truncated hemoglobins
KB226_RS03170	COG2357	RelA SpoT domain protein
KB226_RS03175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KB226_RS03180	COG0564	pseudouridine synthase activity
KB226_RS03185	COG2239	Acts as a magnesium transporter
KB226_RS03190	COG0475	glutathione-regulated potassium exporter activity
KB226_RS03190	COG0569	domain protein
KB226_RS03250	COG0628	permease
KB226_RS03255	COG2382	esterase
KB226_RS03260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KB226_RS03265	COG2814	Major facilitator Superfamily
KB226_RS03270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KB226_RS03275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KB226_RS03285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KB226_RS03290	COG0861	Integral membrane protein TerC family
KB226_RS03295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KB226_RS03300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KB226_RS03305	COG0737	Belongs to the 5'-nucleotidase family
KB226_RS03315	COG4873	Protein conserved in bacteria
KB226_RS03370	COG2314	TM2 domain
KB226_RS03375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KB226_RS03380	COG1575	Belongs to the MenA family. Type 1 subfamily
KB226_RS03385	COG1169	isochorismate synthase
KB226_RS03390	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KB226_RS03400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KB226_RS03405	COG0436	Aminotransferase
KB226_RS03410	COG3594	Acyltransferase
KB226_RS03435	COG1316	TRANSCRIPTIONal
KB226_RS03450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KB226_RS03455	COG1845	cytochrome c oxidase, subunit III
KB226_RS03460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KB226_RS03465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KB226_RS03475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KB226_RS03480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KB226_RS03485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KB226_RS03490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KB226_RS03495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KB226_RS03500	COG0047	phosphoribosylformylglycinamidine synthase activity
KB226_RS03505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KB226_RS03510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KB226_RS03515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KB226_RS03520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KB226_RS03525	COG0138	bifunctional purine biosynthesis protein purh
KB226_RS03530	COG0151	Belongs to the GarS family
KB226_RS03535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KB226_RS03540	COG4172	Belongs to the ABC transporter superfamily
KB226_RS03550	COG4716	Myosin-crossreactive antigen
KB226_RS03565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KB226_RS03575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KB226_RS03580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KB226_RS03590	COG1271	oxidase subunit
KB226_RS03595	COG1294	oxidase, subunit
KB226_RS03600	COG0569	domain protein
KB226_RS03605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KB226_RS03610	COG5503	Protein of unknown function (DUF1447)
KB226_RS03615	COG0242	peptide deformylase activity
KB226_RS03625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KB226_RS03630	COG0022	dehydrogenase e1 component
KB226_RS03635	COG0508	dehydrogenase complex catalyzes the overall conversion of
KB226_RS03645	COG4476	Belongs to the UPF0223 family
KB226_RS03655	COG3842	ATPase activity
KB226_RS03660	COG1176	ABC-type spermidine putrescine transport system, permease component I
KB226_RS03685	COG1914	H( )-stimulated, divalent metal cation uptake system
KB226_RS03690	COG4493	Belongs to the UPF0637 family
KB226_RS03695	COG0483	inositol monophosphate 1-phosphatase activity
KB226_RS03705	COG1217	gtp-binding protein TYPA
KB226_RS03715	COG4896	Protein conserved in bacteria
KB226_RS03720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KB226_RS03725	COG4838	Belongs to the UPF0358 family
KB226_RS03730	COG0772	Belongs to the SEDS family
KB226_RS03740	COG1612	heme a metabolic process
KB226_RS03745	COG0109	protoheme IX farnesyltransferase activity
KB226_RS03755	COG2340	Cysteine-rich secretory protein family
KB226_RS03760	COG3679	Belongs to the UPF0342 family
KB226_RS03765	COG0584	glycerophosphoryl diester phosphodiesterase
KB226_RS03770	COG4471	UPF0298 protein
KB226_RS03780	COG0742	ribosomal rna small subunit methyltransferase
KB226_RS03785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KB226_RS03790	COG1323	Belongs to the UPF0348 family
KB226_RS03800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KB226_RS03810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KB226_RS03815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KB226_RS03820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KB226_RS03820	COG0072	phenylalanine-tRNA ligase activity
KB226_RS03825	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KB226_RS03830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KB226_RS03840	COG1796	DNA polymerase
KB226_RS03840	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KB226_RS03845	COG1193	negative regulation of DNA recombination
KB226_RS03850	COG3118	belongs to the thioredoxin family
KB226_RS03855	COG0322	excinuclease ABC activity
KB226_RS03865	COG2009	succinate dehydrogenase
KB226_RS03870	COG1053	succinate dehydrogenase
KB226_RS03875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KB226_RS03880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KB226_RS03885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KB226_RS03920	COG1011	Hydrolase
KB226_RS03925	COG0454	-acetyltransferase
KB226_RS03930	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KB226_RS03935	COG2001	Belongs to the MraZ family
KB226_RS03940	COG0275	rRNA processing
KB226_RS03945	COG4839	cell division protein FtsL
KB226_RS03950	COG0768	penicillin binding
KB226_RS03955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KB226_RS03960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KB226_RS03965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KB226_RS03970	COG0849	cell division
KB226_RS03975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KB226_RS03980	COG1496	oxidoreductase activity
KB226_RS03985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KB226_RS03990	COG1799	cell septum assembly
KB226_RS03995	COG0762	integral membrane protein
KB226_RS04005	COG3599	regulation of cell shape
KB226_RS04010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KB226_RS04020	COG3942	CHAP domain
KB226_RS04020	COG1388	LysM domain
KB226_RS04025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KB226_RS04030	COG0564	pseudouridine synthase activity
KB226_RS04035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KB226_RS04040	COG2233	PERMEase
KB226_RS04045	COG0540	Belongs to the ATCase OTCase family
KB226_RS04050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KB226_RS04055	COG0505	Belongs to the CarA family
KB226_RS04060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KB226_RS04065	COG0284	orotidine-5'-phosphate decarboxylase activity
KB226_RS04070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KB226_RS04090	COG0194	GDP metabolic process
KB226_RS04095	COG1758	RNA polymerase activity
KB226_RS04100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KB226_RS04105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KB226_RS04115	COG0242	peptide deformylase activity
KB226_RS04120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KB226_RS04125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KB226_RS04125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KB226_RS04130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KB226_RS04135	COG0631	protein serine/threonine phosphatase activity
KB226_RS04145	COG1162	GTPase activity
KB226_RS04150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KB226_RS04160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KB226_RS04165	COG1302	Protein conserved in bacteria
KB226_RS04170	COG1461	Dihydroxyacetone kinase
KB226_RS04175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KB226_RS04180	COG1349	DNA-binding transcription factor activity
KB226_RS04185	COG0416	fatty acid biosynthetic process
KB226_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS04200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KB226_RS04205	COG0571	ribonuclease III activity
KB226_RS04210	COG1196	nuclear chromosome segregation
KB226_RS04215	COG0552	protein localization to endoplasmic reticulum
KB226_RS04220	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KB226_RS04225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KB226_RS04230	COG0228	four-way junction DNA binding
KB226_RS04235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KB226_RS04240	COG0336	Belongs to the RNA methyltransferase TrmD family
KB226_RS04245	COG0335	large ribosomal subunit rRNA binding
KB226_RS04255	COG4485	Bacterial membrane protein, YfhO
KB226_RS04265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KB226_RS04270	COG0045	succinate-CoA ligase (ADP-forming) activity
KB226_RS04275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KB226_RS04285	COG0758	DNA mediated transformation
KB226_RS04290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KB226_RS04295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KB226_RS04300	COG4974	Belongs to the 'phage' integrase family
KB226_RS04305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KB226_RS04310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KB226_RS04315	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KB226_RS04320	COG0052	Belongs to the universal ribosomal protein uS2 family
KB226_RS04325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KB226_RS04330	COG0528	UMP kinase activity
KB226_RS04335	COG0233	cytoplasmic translational termination
KB226_RS04340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KB226_RS04345	COG4589	Belongs to the CDS family
KB226_RS04355	COG0442	prolyl-tRNA aminoacylation
KB226_RS04360	COG2176	DNA-directed DNA polymerase activity
KB226_RS04365	COG0779	Required for maturation of 30S ribosomal subunits
KB226_RS04370	COG0195	Participates in both transcription termination and antitermination
KB226_RS04375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KB226_RS04380	COG1358	cellular component organization or biogenesis
KB226_RS04385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KB226_RS04390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KB226_RS04395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KB226_RS04400	COG0196	riboflavin kinase activity
KB226_RS04405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KB226_RS04410	COG1185	polyribonucleotide nucleotidyltransferase activity
KB226_RS04415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KB226_RS04420	COG1674	ftsk spoiiie
KB226_RS04425	COG2188	Transcriptional regulator
KB226_RS04430	COG0612	Peptidase, M16
KB226_RS04435	COG0612	Peptidase, M16
KB226_RS04440	COG0300	oxidoreductase activity
KB226_RS04455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KB226_RS04460	COG1546	Belongs to the CinA family
KB226_RS04460	COG1058	Belongs to the CinA family
KB226_RS04465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KB226_RS04470	COG1418	mRNA catabolic process
KB226_RS04480	COG1692	metallophosphoesterase
KB226_RS04485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KB226_RS04485	COG0674	pyruvate-flavodoxin oxidoreductase activity
KB226_RS04490	COG1013	pyruvate-flavodoxin oxidoreductase activity
KB226_RS04495	COG4195	phage-related replication protein
KB226_RS04505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KB226_RS04510	COG4550	Control of competence regulator ComK, YlbF/YmcA
KB226_RS04520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KB226_RS04525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KB226_RS04530	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KB226_RS04535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KB226_RS04540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KB226_RS04545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KB226_RS04555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KB226_RS04560	COG1923	regulation of RNA biosynthetic process
KB226_RS04565	COG0386	Belongs to the glutathione peroxidase family
KB226_RS04570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KB226_RS04575	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KB226_RS04580	COG0789	Transcriptional regulator
KB226_RS04585	COG0174	glutamine synthetase
KB226_RS04630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KB226_RS04635	COG1131	(ABC) transporter
KB226_RS04645	COG4585	Histidine kinase
KB226_RS04650	COG2197	response regulator
KB226_RS04660	COG1525	nuclease
KB226_RS04675	COG0527	aspartate kinase activity
KB226_RS04680	COG0460	homoserine dehydrogenase
KB226_RS04685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KB226_RS04690	COG0083	homoserine kinase activity
KB226_RS04710	COG0833	amino acid
KB226_RS04715	COG0753	catalase activity
KB226_RS04725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KB226_RS04730	COG0516	GMP reductase activity
KB226_RS04735	COG2340	Cysteine-rich secretory protein family
KB226_RS04740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KB226_RS04750	COG4224	UPF0291 protein
KB226_RS04755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KB226_RS04765	COG4846	Membrane protein involved in cytochrome C biogenesis
KB226_RS04770	COG0420	3'-5' exonuclease activity
KB226_RS04775	COG0419	ATPase involved in DNA repair
KB226_RS04780	COG1970	mechanosensitive ion channel activity
KB226_RS04785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KB226_RS04790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KB226_RS04795	COG0824	Thioesterase
KB226_RS04800	COG4841	protein insertion into membrane
KB226_RS04805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KB226_RS04810	COG0187	DNA topoisomerase II activity
KB226_RS04815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KB226_RS04820	COG1115	amino acid carrier protein
KB226_RS04825	COG3711	transcriptional antiterminator
KB226_RS04830	COG0628	permease
KB226_RS04835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KB226_RS04835	COG0392	lysyltransferase activity
KB226_RS04850	COG1942	4-Oxalocrotonate Tautomerase
KB226_RS04855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KB226_RS04860	COG0287	Prephenate dehydrogenase
KB226_RS04865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KB226_RS04870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KB226_RS04870	COG0512	Glutamine amidotransferase of anthranilate synthase
KB226_RS04875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KB226_RS04880	COG0134	indole-3-glycerol-phosphate synthase activity
KB226_RS04885	COG0135	phosphoribosylanthranilate isomerase activity
KB226_RS04890	COG0133	tryptophan synthase activity
KB226_RS04895	COG0159	tryptophan synthase activity
KB226_RS04905	COG2348	transferase activity, transferring amino-acyl groups
KB226_RS04910	COG2348	transferase activity, transferring amino-acyl groups
KB226_RS04950	COG0704	Plays a role in the regulation of phosphate uptake
KB226_RS04955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KB226_RS04960	COG0581	inorganic phosphate transmembrane transporter activity
KB226_RS04965	COG0573	inorganic phosphate transmembrane transporter activity
KB226_RS04970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KB226_RS04975	COG2996	Protein conserved in bacteria
KB226_RS04980	COG0488	(ABC) transporter
KB226_RS04985	COG0527	aspartate kinase activity
KB226_RS04990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KB226_RS04995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KB226_RS05000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KB226_RS05005	COG2171	N-acyltransferase activity
KB226_RS05010	COG1473	amidohydrolase
KB226_RS05030	COG1131	(ABC) transporter
KB226_RS05045	COG1278	Cold shock
KB226_RS05055	COG1254	Belongs to the acylphosphatase family
KB226_RS05065	COG3853	Toxic anion resistance protein (TelA)
KB226_RS05070	COG1114	Component of the transport system for branched-chain amino acids
KB226_RS05075	COG4548	von Willebrand factor, type A
KB226_RS05080	COG0714	Associated with various cellular activities
KB226_RS05100	COG0508	dehydrogenase complex catalyzes the overall conversion of
KB226_RS05110	COG5002	protein histidine kinase activity
KB226_RS05115	COG0745	RESPONSE REGULATOR receiver
KB226_RS05120	COG1349	DNA-binding transcription factor activity
KB226_RS05125	COG0534	Mate efflux family protein
KB226_RS05135	COG0395	ABC-type sugar transport system, permease component
KB226_RS05145	COG4209	transmembrane transport
KB226_RS05150	COG3842	ATPase activity
KB226_RS05155	COG0671	phosphoesterase, PA-phosphatase related
KB226_RS05160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KB226_RS05170	COG0793	Belongs to the peptidase S41A family
KB226_RS05175	COG4479	Belongs to the UPF0346 family
KB226_RS05180	COG2190	(PTS) system
KB226_RS05185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KB226_RS05210	COG1136	(ABC) transporter
KB226_RS05225	COG1413	lyase activity
KB226_RS05235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KB226_RS05245	COG1196	nuclear chromosome segregation
KB226_RS05245	COG4372	Transposase
KB226_RS05245	COG1511	domain protein
KB226_RS05250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KB226_RS05255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KB226_RS05265	COG0116	Belongs to the methyltransferase superfamily
KB226_RS05275	COG3599	regulation of cell shape
KB226_RS05280	COG4474	Belongs to the UPF0398 family
KB226_RS05290	COG3331	DNA recombination
KB226_RS05295	COG4499	WXG100 protein secretion system (Wss), protein YukC
KB226_RS05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KB226_RS05305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KB226_RS05310	COG3935	DnaD domain protein
KB226_RS05315	COG0017	Asparaginyl-tRNA synthetase
KB226_RS05320	COG1199	ATP-dependent helicase activity
KB226_RS05320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KB226_RS05325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KB226_RS05325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KB226_RS05330	COG0617	tRNA 3'-terminal CCA addition
KB226_RS05335	COG0438	transferase activity, transferring glycosyl groups
KB226_RS05340	COG1694	Mazg nucleotide pyrophosphohydrolase
KB226_RS05345	COG2738	Putative neutral zinc metallopeptidase
KB226_RS05350	COG4347	Protein of unknown function (DUF1405)
KB226_RS05355	COG5582	Belongs to the UPF0302 family
KB226_RS05365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KB226_RS05370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KB226_RS05375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KB226_RS05380	COG0105	UTP biosynthetic process
KB226_RS05390	COG2226	methyltransferase
KB226_RS05405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KB226_RS05410	COG1160	GTP binding
KB226_RS05415	COG0539	negative regulation of cytoplasmic translation
KB226_RS05420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KB226_RS05425	COG0252	asparaginase activity
KB226_RS05430	COG0492	ferredoxin-NADP+ reductase activity
KB226_RS05435	COG1388	LysM domain
KB226_RS05440	COG0514	ATP-dependent DNA helicase (RecQ)
KB226_RS05450	COG1141	Ferredoxin
KB226_RS05465	COG0745	RESPONSE REGULATOR receiver
KB226_RS05470	COG1187	pseudouridine synthase activity
KB226_RS05475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KB226_RS05480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KB226_RS05485	COG1547	Domain of unknown function (DUF309)
KB226_RS05490	COG4974	Belongs to the 'phage' integrase family
KB226_RS05495	COG0735	belongs to the Fur family
KB226_RS05500	COG0494	nUDIX hydrolase
KB226_RS05505	COG0667	Aldo Keto reductase
KB226_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS05515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KB226_RS05520	COG1234	tRNA 3'-trailer cleavage
KB226_RS05525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KB226_RS05535	COG0366	Alpha amylase catalytic
KB226_RS05540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KB226_RS05545	COG2195	Cleaves the N-terminal amino acid of tripeptides
KB226_RS05555	COG4129	membrane
KB226_RS05565	COG0508	dehydrogenase complex catalyzes the overall conversion of
KB226_RS05570	COG0022	dehydrogenase e1 component
KB226_RS05575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KB226_RS05580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KB226_RS05585	COG0497	DNA recombination
KB226_RS05590	COG1438	arginine binding
KB226_RS05600	COG1722	exodeoxyribonuclease VII activity
KB226_RS05605	COG1570	exodeoxyribonuclease VII activity
KB226_RS05610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KB226_RS05615	COG1302	Protein conserved in bacteria
KB226_RS05620	COG0439	Biotin carboxylase
KB226_RS05625	COG0511	ligase activity, forming carbon-carbon bonds
KB226_RS05630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KB226_RS05635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KB226_RS05640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KB226_RS05645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KB226_RS05650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KB226_RS05655	COG0006	proline dipeptidase activity
KB226_RS05670	COG0095	Lipoate-protein ligase
KB226_RS05675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KB226_RS05685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KB226_RS05690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KB226_RS05695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KB226_RS05700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KB226_RS05720	COG4537	Required for transformation and DNA binding
KB226_RS05725	COG1459	type II secretion system
KB226_RS05730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KB226_RS05740	COG0011	TIGRFAM Protein of
KB226_RS05745	COG1940	carbohydrate kinase activity
KB226_RS05750	COG4483	Protein conserved in bacteria
KB226_RS05760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KB226_RS05765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KB226_RS05770	COG0768	penicillin binding
KB226_RS05775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KB226_RS05780	COG0735	belongs to the Fur family
KB226_RS05785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KB226_RS05790	COG1121	(ABC) transporter
KB226_RS05795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KB226_RS05800	COG0513	Belongs to the DEAD box helicase family
KB226_RS05805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KB226_RS05810	COG2384	SAM-dependent methyltransferase
KB226_RS05815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KB226_RS05820	COG0358	DNA primase activity
KB226_RS05825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KB226_RS05830	COG0517	IMP dehydrogenase activity
KB226_RS05835	COG0423	glycine-tRNA ligase activity
KB226_RS05840	COG1381	Involved in DNA repair and RecF pathway recombination
KB226_RS05845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KB226_RS05850	COG0295	cytidine deaminase activity
KB226_RS05855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KB226_RS05860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KB226_RS05865	COG1702	phosphate starvation-inducible protein PhoH
KB226_RS05875	COG4864	UPF0365 protein
KB226_RS05880	COG1030	water channel activity
KB226_RS05890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KB226_RS05895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KB226_RS05900	COG2264	protein methyltransferase activity
KB226_RS05905	COG0484	heat shock protein binding
KB226_RS05910	COG0443	Heat shock 70 kDa protein
KB226_RS05915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KB226_RS05920	COG1420	regulation of RNA biosynthetic process
KB226_RS05925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KB226_RS05930	COG0481	GTPase activity
KB226_RS05935	COG0268	Binds directly to 16S ribosomal RNA
KB226_RS05940	COG1466	dna polymerase III delta subunit
KB226_RS05945	COG2333	competence protein COMEC
KB226_RS05945	COG0658	competence protein
KB226_RS05950	COG2131	deaminase
KB226_RS05960	COG2226	methyltransferase
KB226_RS05965	COG0799	negative regulation of ribosome biogenesis
KB226_RS05970	COG1713	HD superfamily hydrolase involved in NAD metabolism
KB226_RS05975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KB226_RS05980	COG1534	Rna-binding protein
KB226_RS05985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KB226_RS05990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KB226_RS05995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KB226_RS06000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KB226_RS06005	COG1914	H( )-stimulated, divalent metal cation uptake system
KB226_RS06010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KB226_RS06015	COG0439	Biotin carboxylase
KB226_RS06020	COG0511	ligase activity, forming carbon-carbon bonds
KB226_RS06025	COG1984	allophanate hydrolase subunit 2
KB226_RS06030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KB226_RS06040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KB226_RS06045	COG0572	uridine kinase
KB226_RS06050	COG0826	peptidase U32
KB226_RS06055	COG0826	peptidase U32
KB226_RS06065	COG3906	Belongs to the UPF0473 family
KB226_RS06070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KB226_RS06075	COG4472	Bacterial protein of unknown function (DUF965)
KB226_RS06080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KB226_RS06085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KB226_RS06095	COG0482	sulfurtransferase activity
KB226_RS06100	COG1104	cysteine desulfurase activity
KB226_RS06105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KB226_RS06115	COG1959	2 iron, 2 sulfur cluster binding
KB226_RS06120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KB226_RS06125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KB226_RS06135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KB226_RS06140	COG0124	histidyl-tRNA synthetase
KB226_RS06145	COG0860	N-Acetylmuramoyl-L-alanine amidase
KB226_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
KB226_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KB226_RS06165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KB226_RS06165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KB226_RS06170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KB226_RS06170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KB226_RS06175	COG1862	Preprotein translocase
KB226_RS06180	COG0343	queuine tRNA-ribosyltransferase activity
KB226_RS06185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KB226_RS06190	COG2255	four-way junction helicase activity
KB226_RS06195	COG0632	four-way junction helicase activity
KB226_RS06200	COG4492	Belongs to the UPF0735 family
KB226_RS06205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KB226_RS06210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KB226_RS06215	COG2868	ribosomal protein
KB226_RS06220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KB226_RS06250	COG2003	Belongs to the UPF0758 family
KB226_RS06260	COG0285	dihydrofolate synthase activity
KB226_RS06265	COG0525	valine-tRNA ligase activity
KB226_RS06270	COG2818	Glycosylase
KB226_RS06280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KB226_RS06285	COG0113	porphobilinogen synthase activity
KB226_RS06295	COG0181	hydroxymethylbilane synthase activity
KB226_RS06305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KB226_RS06310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KB226_RS06315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KB226_RS06320	COG0544	peptidyl-prolyl cis-trans isomerase activity
KB226_RS06330	COG4112	unkown
KB226_RS06335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KB226_RS06340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KB226_RS06345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KB226_RS06350	COG0833	amino acid
KB226_RS06355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KB226_RS06360	COG1484	DNA-dependent DNA replication
KB226_RS06365	COG3611	Membrane attachment protein
KB226_RS06370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KB226_RS06375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KB226_RS06385	COG0237	dephospho-CoA kinase activity
KB226_RS06390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KB226_RS06395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KB226_RS06395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KB226_RS06400	COG5002	protein histidine kinase activity
KB226_RS06405	COG0745	RESPONSE REGULATOR receiver
KB226_RS06410	COG0538	isocitrate dehydrogenase activity
KB226_RS06415	COG0372	Belongs to the citrate synthase family
KB226_RS06420	COG1113	amino acid transport
KB226_RS06425	COG0469	pyruvate kinase activity
KB226_RS06430	COG0205	6-phosphofructokinase activity
KB226_RS06435	COG0825	malonyl-CoA metabolic process
KB226_RS06440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KB226_RS06445	COG0281	malic enzyme
KB226_RS06450	COG0587	DNA-directed DNA polymerase activity
KB226_RS06455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KB226_RS06460	COG4109	DRTGG domain
KB226_RS06470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KB226_RS06475	COG0006	proline dipeptidase activity
KB226_RS06480	COG0686	Belongs to the AlaDH PNT family
KB226_RS06485	COG0589	response to stress
KB226_RS06495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KB226_RS06500	COG0827	DNA restriction-modification system
KB226_RS06505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KB226_RS06515	COG0301	tRNA thio-modification
KB226_RS06525	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KB226_RS06530	COG1956	GAF domain-containing protein
KB226_RS06535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KB226_RS06540	COG0584	glycerophosphoryl diester phosphodiesterase
KB226_RS06545	COG1764	response to oxidative stress
KB226_RS06550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KB226_RS06555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KB226_RS06565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KB226_RS06565	COG1263	PTS System
KB226_RS06570	COG0204	Acyl-transferase
KB226_RS06575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KB226_RS06580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KB226_RS06590	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KB226_RS06595	COG1609	Transcriptional regulator
KB226_RS06600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KB226_RS06600	COG1605	Chorismate mutase
KB226_RS06610	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KB226_RS06615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KB226_RS06620	COG1674	ftsk spoiiie
KB226_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KB226_RS06630	COG4848	Belongs to the UPF0354 family
KB226_RS06635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KB226_RS06640	COG1363	Peptidase, m42
KB226_RS06650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KB226_RS06655	COG0510	thiamine kinase activity
KB226_RS06660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KB226_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KB226_RS06675	COG1187	pseudouridine synthase activity
KB226_RS06680	COG2244	polysaccharide biosynthetic process
KB226_RS06685	COG2081	HI0933 family
KB226_RS06700	COG0495	leucyl-tRNA aminoacylation
KB226_RS06705	COG2814	Major facilitator Superfamily
KB226_RS06710	COG1242	4 iron, 4 sulfur cluster binding
KB226_RS06715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KB226_RS06725	COG2267	carboxylic ester hydrolase activity
KB226_RS06730	COG0506	proline dehydrogenase activity
KB226_RS06735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KB226_RS06740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KB226_RS06740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KB226_RS06750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KB226_RS06750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KB226_RS06760	COG3266	domain, Protein
KB226_RS06760	COG4193	domain, Protein
KB226_RS06760	COG5632	N-Acetylmuramoyl-L-alanine amidase
KB226_RS06785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KB226_RS06795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KB226_RS06800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KB226_RS06820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KB226_RS06825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KB226_RS06830	COG1506	peptidase
KB226_RS06835	COG0494	nUDIX hydrolase
KB226_RS06840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KB226_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
KB226_RS06925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KB226_RS06930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KB226_RS06935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KB226_RS06940	COG2329	Antibiotic biosynthesis monooxygenase
KB226_RS06950	COG4473	ABC transporter
KB226_RS06955	COG1131	(ABC) transporter
KB226_RS06960	COG0537	adenosine 5'-monophosphoramidase activity
KB226_RS06975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KB226_RS06985	COG3481	metal-dependent phosphohydrolase, HD sub domain
KB226_RS06995	COG0420	3'-5' exonuclease activity
KB226_RS07000	COG3679	Belongs to the UPF0342 family
KB226_RS07005	COG4399	Belongs to the UPF0754 family
KB226_RS07015	COG2197	response regulator
KB226_RS07020	COG4585	Histidine kinase
KB226_RS07020	COG2203	Gaf domain
KB226_RS07025	COG0564	pseudouridine synthase activity
KB226_RS07030	COG0114	fumarate hydratase activity
KB226_RS07045	COG0363	glucosamine-6-phosphate deaminase activity
KB226_RS07055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KB226_RS07065	COG1126	abc transporter atp-binding protein
KB226_RS07240	COG0735	belongs to the Fur family
KB226_RS07245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KB226_RS07250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KB226_RS07255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KB226_RS07260	COG4129	membrane
KB226_RS07270	COG3557	Belongs to the UPF0374 family
KB226_RS07280	COG1988	membrane-bound metal-dependent
KB226_RS07290	COG1134	teichoic acid transport
KB226_RS07290	COG1388	LysM domain
KB226_RS07300	COG2137	regulation of response to DNA damage stimulus
KB226_RS07305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KB226_RS07310	COG0693	protein deglycase activity
KB226_RS07320	COG0535	radical SAM domain protein
KB226_RS07325	COG1607	acyl-coa hydrolase
KB226_RS07330	COG2309	aminopeptidase activity
KB226_RS07335	COG4840	Belongs to the UPF0435 family
KB226_RS07340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KB226_RS07350	COG1295	ribonuclease BN
KB226_RS07355	COG2197	response regulator
KB226_RS07360	COG4585	Histidine kinase
KB226_RS07375	COG0024	Methionine aminopeptidase
KB226_RS07380	COG4129	membrane
KB226_RS07400	COG1528	Iron-storage protein
KB226_RS07410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KB226_RS07420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KB226_RS07425	COG1597	lipid kinase activity
KB226_RS07430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KB226_RS07435	COG0154	amidase activity
KB226_RS07440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KB226_RS07445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KB226_RS07450	COG4851	CamS sex pheromone cAM373 precursor
KB226_RS07455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KB226_RS07460	COG0210	DNA helicase
KB226_RS07465	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KB226_RS07470	COG4496	protein, YerC YecD
KB226_RS07475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KB226_RS07485	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KB226_RS07490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KB226_RS07495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KB226_RS07505	COG0077	Prephenate dehydratase
KB226_RS07515	COG1335	isochorismatase
KB226_RS07520	COG1227	inorganic diphosphatase activity
KB226_RS07525	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS07530	COG2706	6-phosphogluconolactonase activity
KB226_RS07540	COG3682	Transcriptional regulator
KB226_RS07570	COG4974	Belongs to the 'phage' integrase family
KB226_RS07620	COG1131	(ABC) transporter
KB226_RS07630	COG1131	(ABC) transporter
KB226_RS07635	COG1725	Transcriptional regulator
KB226_RS07785	COG0582	viral genome integration into host DNA
KB226_RS07790	COG0459	protein refolding
KB226_RS07795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KB226_RS07835	COG3290	protein histidine kinase activity
KB226_RS07840	COG3279	Response regulator of the LytR AlgR family
KB226_RS07850	COG1621	beta-fructofuranosidase activity
KB226_RS07855	COG1609	Transcriptional regulator
KB226_RS07860	COG0004	ammonium transporteR
KB226_RS07865	COG0425	Belongs to the sulfur carrier protein TusA family
KB226_RS07870	COG2391	methyltransferase activity
KB226_RS07880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KB226_RS07885	COG0488	(ABC) transporter
KB226_RS07890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KB226_RS07895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KB226_RS07900	COG0456	acetyltransferase
KB226_RS07905	COG1214	PFAM Peptidase M22, glycoprotease
KB226_RS07910	COG0802	atpase or kinase
KB226_RS07915	COG0129	dihydroxy-acid dehydratase activity
KB226_RS07920	COG0028	Belongs to the TPP enzyme family
KB226_RS07930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KB226_RS07935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KB226_RS07940	COG0473	3-isopropylmalate dehydrogenase activity
KB226_RS07950	COG0066	3-isopropylmalate dehydratase activity
KB226_RS07955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KB226_RS07985	COG3091	SprT-like family
KB226_RS07990	COG2183	response to ionizing radiation
KB226_RS07995	COG1191	sigma factor activity
KB226_RS08010	COG2208	phosphoserine phosphatase activity
KB226_RS08015	COG2337	Toxic component of a toxin-antitoxin (TA) module
KB226_RS08025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KB226_RS08030	COG0736	holo-[acyl-carrier-protein] synthase activity
KB226_RS08035	COG3402	PFAM membrane-flanked domain
KB226_RS08040	COG3428	Bacterial PH domain
KB226_RS08050	COG0513	Belongs to the DEAD box helicase family
KB226_RS08055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KB226_RS08060	COG1181	Belongs to the D-alanine--D-alanine ligase family
KB226_RS08065	COG0772	Belongs to the SEDS family
KB226_RS08080	COG1937	Protein conserved in bacteria
KB226_RS08085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KB226_RS08090	COG1418	mRNA catabolic process
KB226_RS08095	COG0706	membrane insertase activity
KB226_RS08100	COG0352	thiamine-phosphate diphosphorylase activity
KB226_RS08105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KB226_RS08115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KB226_RS08120	COG1388	LysM domain
KB226_RS08125	COG0629	single-stranded DNA binding
KB226_RS08135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KB226_RS08140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KB226_RS08150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KB226_RS08155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KB226_RS08160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KB226_RS08165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KB226_RS08170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KB226_RS08175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KB226_RS08185	COG0356	it plays a direct role in the translocation of protons across the membrane
KB226_RS08195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KB226_RS08200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KB226_RS08205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KB226_RS08210	COG4475	Protein of unknown function (DUF436)
KB226_RS08215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KB226_RS08220	COG0009	L-threonylcarbamoyladenylate synthase
KB226_RS08225	COG2890	protein-(glutamine-N5) methyltransferase activity
KB226_RS08230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KB226_RS08235	COG1435	thymidine kinase activity
KB226_RS08240	COG0254	rRNA binding
KB226_RS08245	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KB226_RS08250	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS08255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KB226_RS08260	COG0191	fructose-bisphosphate aldolase activity
KB226_RS08270	COG0504	CTP synthase activity
KB226_RS08275	COG3343	RNA polymerase activity
KB226_RS08285	COG5146	pantothenate kinase activity
KB226_RS08305	COG1854	S-ribosylhomocysteine lyase activity
KB226_RS08315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KB226_RS08320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KB226_RS08325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KB226_RS08330	COG0813	purine-nucleoside phosphorylase activity
KB226_RS08335	COG0783	Belongs to the Dps family
KB226_RS08355	COG1482	cell wall glycoprotein biosynthetic process
KB226_RS08360	COG0702	epimerase
KB226_RS08365	COG0640	Transcriptional regulator
KB226_RS08385	COG0561	phosphatase activity
KB226_RS08390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KB226_RS08400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KB226_RS08410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KB226_RS08460	COG0489	protein tyrosine kinase activity
KB226_RS08465	COG2814	Major facilitator Superfamily
KB226_RS08485	COG4284	Utp--glucose-1-phosphate uridylyltransferase
KB226_RS08490	COG1988	membrane-bound metal-dependent
KB226_RS08500	COG2329	Antibiotic biosynthesis monooxygenase
KB226_RS08505	COG3314	Sporulation integral membrane protein YlbJ
KB226_RS08510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KB226_RS08515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KB226_RS08520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KB226_RS08525	COG3457	Alanine racemase
KB226_RS08530	COG4264	IucA IucC family
KB226_RS08535	COG2814	Major facilitator Superfamily
KB226_RS08540	COG4264	IucA IucC family
KB226_RS08545	COG1302	Protein conserved in bacteria
KB226_RS08560	COG0604	alcohol dehydrogenase
KB226_RS08565	COG2130	NADP-dependent
KB226_RS08570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KB226_RS08580	COG2723	6-phospho-beta-galactosidase activity
KB226_RS08585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KB226_RS08585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KB226_RS08590	COG1447	Phosphotransferase system cellobiose-specific component IIA
KB226_RS08595	COG3684	Belongs to the aldolase LacD family
KB226_RS08600	COG1105	Belongs to the carbohydrate kinase PfkB family
KB226_RS08605	COG0698	ribose 5-phosphate isomerase
KB226_RS08610	COG0698	ribose 5-phosphate isomerase
KB226_RS08615	COG1349	DNA-binding transcription factor activity
KB226_RS08620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KB226_RS08625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KB226_RS08630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KB226_RS08635	COG0101	tRNA pseudouridine synthase activity
KB226_RS08645	COG1122	ATPase activity
KB226_RS08650	COG1122	ATPase activity
KB226_RS08655	COG0203	ribosomal protein L17
KB226_RS08660	COG0202	RNA polymerase activity
KB226_RS08665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KB226_RS08670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KB226_RS08675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KB226_RS08680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KB226_RS08685	COG0563	adenylate kinase activity
KB226_RS08690	COG0201	protein transport
KB226_RS08695	COG0200	Binds to the 23S rRNA
KB226_RS08700	COG1841	ribosomal large subunit assembly
KB226_RS08705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KB226_RS08710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KB226_RS08715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KB226_RS08720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KB226_RS08725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KB226_RS08730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KB226_RS08735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KB226_RS08740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KB226_RS08745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KB226_RS08755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KB226_RS08760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KB226_RS08765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KB226_RS08770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KB226_RS08775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KB226_RS08780	COG0089	rRNA binding
KB226_RS08785	COG0088	Forms part of the polypeptide exit tunnel
KB226_RS08790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KB226_RS08805	COG2252	PERMEase
KB226_RS08810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KB226_RS08810	COG0551	DNA topoisomerase type I activity
KB226_RS08815	COG4975	Glucose uptake
KB226_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS08840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KB226_RS08845	COG2348	transferase activity, transferring amino-acyl groups
KB226_RS08865	COG2814	Major facilitator Superfamily
KB226_RS08890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KB226_RS08895	COG0746	molybdenum cofactor guanylyltransferase activity
KB226_RS08905	COG0314	molybdopterin synthase activity
KB226_RS08915	COG0303	'Molybdopterin
KB226_RS08920	COG0315	cyclic pyranopterin monophosphate synthase activity
KB226_RS08925	COG0521	Mo-molybdopterin cofactor biosynthetic process
KB226_RS08930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KB226_RS08935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KB226_RS08940	COG4149	molybdate abc transporter
KB226_RS08945	COG0725	ABC transporter, periplasmic molybdate-binding protein
KB226_RS08960	COG1268	BioY protein
KB226_RS08965	COG1957	nucleoside hydrolase
KB226_RS08970	COG1960	acyl-CoA dehydrogenase activity
KB226_RS08980	COG0831	urea catabolic process
KB226_RS08985	COG0832	Belongs to the urease beta subunit family
KB226_RS08990	COG0804	urea catabolic process
KB226_RS08995	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KB226_RS09000	COG0830	nickel cation binding
KB226_RS09005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KB226_RS09010	COG0829	nickel cation binding
KB226_RS09035	COG3942	CHAP domain
KB226_RS09040	COG1757	Na H antiporter
KB226_RS09055	COG3942	CHAP domain
KB226_RS09060	COG2076	Multidrug Resistance protein
KB226_RS09065	COG2076	Multidrug Resistance protein
KB226_RS09070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KB226_RS09090	COG1316	TRANSCRIPTIONal
KB226_RS09095	COG0483	inositol monophosphate 1-phosphatase activity
KB226_RS09100	COG2378	regulation of single-species biofilm formation
KB226_RS09105	COG1266	CAAX protease self-immunity
KB226_RS09120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KB226_RS09125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KB226_RS09125	COG1263	PTS System
KB226_RS09135	COG1113	amino acid transport
KB226_RS09155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KB226_RS09165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KB226_RS09165	COG1263	PTS System
KB226_RS09170	COG1737	Transcriptional regulator
KB226_RS09195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KB226_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS09205	COG1473	amidohydrolase
KB226_RS09210	COG0010	Belongs to the arginase family
KB226_RS09215	COG1266	CAAX protease self-immunity
KB226_RS09225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KB226_RS09230	COG2258	MOSC domain
KB226_RS09235	COG2017	converts alpha-aldose to the beta-anomer
KB226_RS09240	COG1069	ribulokinase activity
KB226_RS09250	COG2094	Belongs to the DNA glycosylase MPG family
KB226_RS09270	COG0786	glutamate:sodium symporter activity
KB226_RS09275	COG1304	FMN binding
KB226_RS09280	COG0598	Magnesium transport protein CorA
KB226_RS09295	COG0657	acetylesterase activity
KB226_RS09305	COG2814	Major facilitator Superfamily
KB226_RS09310	COG1566	PFAM secretion protein HlyD family protein
KB226_RS09320	COG2814	Major facilitator Superfamily
KB226_RS09325	COG4640	response to antibiotic
KB226_RS09340	COG1136	(ABC) transporter
KB226_RS09345	COG0577	efflux transmembrane transporter activity
KB226_RS09350	COG0745	RESPONSE REGULATOR receiver
KB226_RS09355	COG5002	protein histidine kinase activity
KB226_RS09355	COG3850	Histidine kinase
KB226_RS09360	COG0579	oxidoreductase
KB226_RS09365	COG0438	transferase activity, transferring glycosyl groups
KB226_RS09370	COG1620	l-lactate permease
KB226_RS09375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KB226_RS09375	COG0463	Glycosyl transferase, family 2
KB226_RS09385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KB226_RS09385	COG0463	Glycosyl transferase, family 2
KB226_RS09390	COG0456	acetyltransferase
KB226_RS09395	COG0604	alcohol dehydrogenase
KB226_RS09435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KB226_RS09435	COG1263	PTS System
KB226_RS09450	COG3871	stress protein (general stress protein 26)
KB226_RS09470	COG0778	Nitroreductase
KB226_RS09475	COG1846	Transcriptional regulator
KB226_RS09480	COG2223	nitrite transmembrane transporter activity
KB226_RS09485	COG2197	response regulator
KB226_RS09490	COG4585	Histidine kinase
KB226_RS09500	COG2181	nitrate reductase activity
KB226_RS09510	COG1140	nitrate reductase beta subunit
KB226_RS09515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KB226_RS09525	COG2146	nitrite reductase [NAD(P)H] activity
KB226_RS09530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KB226_RS09540	COG0747	negative chemotaxis
KB226_RS09550	COG0454	-acetyltransferase
KB226_RS09555	COG2116	formate transmembrane transporter activity
KB226_RS09575	COG2348	transferase activity, transferring amino-acyl groups
KB226_RS09585	COG1126	abc transporter atp-binding protein
KB226_RS09590	COG0765	amino acid transport
KB226_RS09595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KB226_RS09605	COG0588	phosphoglycerate mutase activity
KB226_RS09610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KB226_RS09625	COG1929	Belongs to the glycerate kinase type-1 family
KB226_RS09650	COG1113	amino acid transport
KB226_RS09655	COG0531	amino acid
KB226_RS09665	COG0706	membrane insertase activity
KB226_RS09670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KB226_RS09680	COG3275	phosphorelay sensor kinase activity
KB226_RS09685	COG3279	Response regulator of the LytR AlgR family
KB226_RS09690	COG1380	Effector of murein hydrolase LrgA
KB226_RS09695	COG1346	cytolysis
KB226_RS09700	COG1174	glycine betaine transport
KB226_RS09730	COG0531	amino acid
KB226_RS09735	COG2272	Belongs to the type-B carboxylesterase lipase family
KB226_RS09740	COG2814	Major facilitator Superfamily
KB226_RS09745	COG0390	transport system, permease component
KB226_RS09750	COG4619	ABC transporter
KB226_RS09765	COG0069	glutamate synthase activity
KB226_RS09775	COG1363	Peptidase, m42
KB226_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS09790	COG0248	Ppx GppA phosphatase
KB226_RS09795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KB226_RS09800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KB226_RS09805	COG4221	oxidoreductase activity
KB226_RS09820	COG0556	nucleotide-excision repair
KB226_RS09825	COG0494	nUDIX hydrolase
KB226_RS09830	COG0438	transferase activity, transferring glycosyl groups
KB226_RS09835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KB226_RS09840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KB226_RS09845	COG2610	gluconate transmembrane transporter activity
KB226_RS09855	COG1802	Transcriptional regulator
KB226_RS09860	COG2271	Major facilitator Superfamily
KB226_RS09865	COG0789	Transcriptional regulator
KB226_RS09880	COG2357	RelA SpoT domain protein
KB226_RS09885	COG4876	unkown
KB226_RS09900	COG2271	Major facilitator Superfamily
KB226_RS09910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KB226_RS09920	COG2022	thiamine diphosphate biosynthetic process
KB226_RS09925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KB226_RS09930	COG0586	Pfam SNARE associated Golgi protein
KB226_RS09935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KB226_RS09945	COG3949	Membrane
KB226_RS09950	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS09965	COG2514	catechol 2,3-dioxygenase activity
KB226_RS09975	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS09980	COG0778	Nitroreductase
KB226_RS09985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KB226_RS09995	COG3764	Sortase (surface protein transpeptidase)
KB226_RS10015	COG1760	l-serine dehydratase
KB226_RS10020	COG1760	l-serine dehydratase
KB226_RS10035	COG1070	Carbohydrate kinase
KB226_RS10045	COG1869	D-ribose catabolic process
KB226_RS10050	COG4975	Glucose uptake
KB226_RS10065	COG2843	Capsule synthesis protein
KB226_RS10075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KB226_RS10090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KB226_RS10100	COG1063	alcohol dehydrogenase
KB226_RS10110	COG1263	PTS System
KB226_RS10110	COG2190	(PTS) system
KB226_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KB226_RS10115	COG0028	Belongs to the TPP enzyme family
KB226_RS10120	COG1346	cytolysis
KB226_RS10125	COG1380	Effector of murein hydrolase LrgA
KB226_RS10130	COG0583	DNA-binding transcription factor activity
KB226_RS10150	COG3425	synthase
KB226_RS10155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KB226_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS10195	COG2217	Heavy metal translocating P-type atpase
KB226_RS10200	COG2608	mercury ion transmembrane transporter activity
KB226_RS10210	COG0436	Aminotransferase
KB226_RS10215	COG3942	CHAP domain
KB226_RS10225	COG0741	lytic transglycosylase activity
KB226_RS10240	COG1113	amino acid transport
KB226_RS10245	COG3001	Fructosamine kinase
KB226_RS10250	COG0167	dihydroorotate dehydrogenase activity
KB226_RS10265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KB226_RS10280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KB226_RS10285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KB226_RS10290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KB226_RS10300	COG3527	Alpha-acetolactate decarboxylase
KB226_RS10305	COG0028	Belongs to the TPP enzyme family
KB226_RS10310	COG0039	L-malate dehydrogenase activity
KB226_RS10315	COG0583	DNA-binding transcription factor activity
KB226_RS10320	COG0531	amino acid
KB226_RS10350	COG0446	pyridine nucleotide-disulphide oxidoreductase
KB226_RS10355	COG3588	fructose-bisphosphate aldolase
KB226_RS10365	COG0579	oxidoreductase
KB226_RS10370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KB226_RS10375	COG0574	Belongs to the PEP-utilizing enzyme family
KB226_RS10375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KB226_RS10380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KB226_RS10395	COG1473	amidohydrolase
KB226_RS10400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KB226_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
KB226_RS10410	COG1510	regulation of RNA biosynthetic process
KB226_RS10420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KB226_RS10425	COG0602	queuosine metabolic process
KB226_RS10430	COG1328	CTP reductase activity
KB226_RS10440	COG0529	Catalyzes the synthesis of activated sulfate
KB226_RS10445	COG2046	Belongs to the sulfate adenylyltransferase family
KB226_RS10450	COG0730	response to heat
KB226_RS10465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KB226_RS10470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KB226_RS10475	COG0175	sulfate reduction
KB226_RS10480	COG0386	Belongs to the glutathione peroxidase family
KB226_RS10485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KB226_RS10490	COG1846	Transcriptional regulator
KB226_RS10515	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KB226_RS10530	COG1136	(ABC) transporter
KB226_RS10535	COG2205	protein histidine kinase activity
KB226_RS10550	COG1785	Belongs to the alkaline phosphatase family
KB226_RS10555	COG0702	epimerase
KB226_RS10570	COG4195	phage-related replication protein
KB226_RS10600	COG3961	Belongs to the TPP enzyme family
KB226_RS10605	COG2843	Capsule synthesis protein
KB226_RS10615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KB226_RS10625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KB226_RS10630	COG2235	arginine
KB226_RS10635	COG1438	arginine binding
KB226_RS10640	COG3227	Zinc metalloprotease (Elastase)
KB226_RS10645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KB226_RS10675	COG3711	transcriptional antiterminator
KB226_RS10675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KB226_RS10680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KB226_RS10680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KB226_RS10680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KB226_RS10685	COG1482	cell wall glycoprotein biosynthetic process
KB226_RS10695	COG1705	Flagellar rod assembly protein muramidase FlgJ
KB226_RS10695	COG3942	CHAP domain
KB226_RS10705	COG1764	response to oxidative stress
KB226_RS10720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KB226_RS10725	COG2814	Major facilitator Superfamily
KB226_RS10750	COG0438	transferase activity, transferring glycosyl groups
KB226_RS10755	COG0653	protein targeting
KB226_RS10765	COG1073	alpha beta
KB226_RS10775	COG0201	protein transport
KB226_RS10795	COG3639	organic phosphonate transmembrane transporter activity
KB226_RS10800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KB226_RS10815	COG0737	Belongs to the 5'-nucleotidase family
KB226_RS10820	COG2814	Major facilitator Superfamily
KB226_RS10835	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KB226_RS10840	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KB226_RS10845	COG0140	phosphoribosyl-ATP diphosphatase activity
KB226_RS10845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KB226_RS10850	COG0107	imidazoleglycerol-phosphate synthase activity
KB226_RS10855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KB226_RS10860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KB226_RS10865	COG0131	Imidazoleglycerol-phosphate dehydratase
KB226_RS10870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KB226_RS10875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KB226_RS10880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KB226_RS10905	COG0579	oxidoreductase
KB226_RS10910	COG2353	YceI-like domain
KB226_RS10915	COG3386	PFAM SMP-30 Gluconolaconase
KB226_RS10920	COG1054	Belongs to the UPF0176 family
KB226_RS10925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KB226_RS10950	COG0508	dehydrogenase complex catalyzes the overall conversion of
KB226_RS10955	COG0022	dehydrogenase e1 component
KB226_RS10960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KB226_RS10965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KB226_RS10970	COG0471	metal ion transport
KB226_RS10975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KB226_RS10980	COG2962	Rard protein
KB226_RS10995	COG2814	Major facilitator Superfamily
KB226_RS11025	COG2814	Major facilitator Superfamily
KB226_RS11040	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KB226_RS11045	COG1461	Dihydroxyacetone kinase
KB226_RS11050	COG2376	Dihydroxyacetone kinase
KB226_RS11060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KB226_RS11065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KB226_RS11070	COG0346	lactoylglutathione lyase activity
KB226_RS11080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KB226_RS11085	COG0549	Belongs to the carbamate kinase family
KB226_RS11090	COG1288	antiporter activity
KB226_RS11125	COG1250	3-hydroxyacyl-CoA dehydrogenase
KB226_RS11130	COG3246	L-lysine catabolic process to acetate
KB226_RS11135	COG1309	transcriptional regulator
KB226_RS11140	COG1114	Component of the transport system for branched-chain amino acids
KB226_RS11145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KB226_RS11150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KB226_RS11155	COG1882	Formate acetyltransferase
KB226_RS11165	COG1124	(ABC) transporter
KB226_RS11170	COG0444	Belongs to the ABC transporter superfamily
KB226_RS11180	COG0601	transmembrane transport
KB226_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS11225	COG0431	NADPH-dependent FMN reductase
KB226_RS11225	COG1053	succinate dehydrogenase
KB226_RS11225	COG3976	FMN-binding domain protein
KB226_RS11235	COG0803	Belongs to the bacterial solute-binding protein 9 family
KB226_RS11250	COG0523	cobalamin synthesis protein
KB226_RS11275	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
KB226_RS11285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KB226_RS11290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KB226_RS11300	COG3583	domain protein
KB226_RS11300	COG4932	domain protein
KB226_RS11300	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KB226_RS11325	COG2972	Histidine kinase
KB226_RS11330	COG2207	Transcriptional regulator
KB226_RS11330	COG4753	response regulator
KB226_RS11340	COG1755	Isoprenylcysteine carboxyl methyltransferase
KB226_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
KB226_RS11355	COG0579	oxidoreductase
KB226_RS11360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KB226_RS11390	COG0561	phosphatase activity
KB226_RS11395	COG0668	transmembrane transport
KB226_RS11410	COG0640	Transcriptional regulator
KB226_RS11430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KB226_RS11435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KB226_RS11440	COG0730	response to heat
KB226_RS11445	COG1937	Protein conserved in bacteria
KB226_RS11450	COG2210	Belongs to the sulfur carrier protein TusA family
KB226_RS11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KB226_RS11460	COG1388	LysM domain
KB226_RS11465	COG2132	Multicopper oxidase
KB226_RS11470	COG2217	Heavy metal translocating P-type atpase
KB226_RS11485	COG5002	protein histidine kinase activity
KB226_RS11490	COG0745	RESPONSE REGULATOR receiver
KB226_RS11505	COG1131	(ABC) transporter
KB226_RS11515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KB226_RS11535	COG0076	glutamate decarboxylase activity
KB226_RS11585	COG1136	(ABC) transporter
KB226_RS11590	COG0577	efflux transmembrane transporter activity
KB226_RS11605	COG0577	efflux transmembrane transporter activity
KB226_RS11610	COG1136	(ABC) transporter
KB226_RS11645	COG1475	DNA binding
KB226_RS11650	COG0357	Ribosomal RNA small subunit methyltransferase G
KB226_RS11655	COG0445	tRNA wobble uridine modification
KB226_RS11660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KB226_RS11665	COG0594	ribonuclease P activity
KB226_RS11685	COG1611	Belongs to the LOG family
KB226_RS11720	COG1686	Belongs to the peptidase S11 family
KB226_RS11750	COG1131	(ABC) transporter
KB226_RS11805	COG1733	regulation of RNA biosynthetic process
KB226_RS11810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KB226_RS11845	COG2311	Membrane
KB226_RS11865	COG3237	CsbD-like
KB226_RS11920	COG2161	toxin-antitoxin pair type II binding
KB226_RS11925	COG0640	Transcriptional regulator
KB226_RS11935	COG0540	Belongs to the ATCase OTCase family
KB226_RS11970	COG2814	Major facilitator Superfamily
KB226_RS11985	COG1682	transport, permease protein