locus-tag	class	description
CFE88_RS00020	COG0604	alcohol dehydrogenase
CFE88_RS00025	COG0456	acetyltransferase
CFE88_RS00030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFE88_RS00030	COG0463	Glycosyl transferase, family 2
CFE88_RS00040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFE88_RS00040	COG0463	Glycosyl transferase, family 2
CFE88_RS00045	COG1620	l-lactate permease
CFE88_RS00055	COG0579	oxidoreductase
CFE88_RS00060	COG3850	Histidine kinase
CFE88_RS00060	COG5002	protein histidine kinase activity
CFE88_RS00065	COG0745	RESPONSE REGULATOR receiver
CFE88_RS00070	COG0577	efflux transmembrane transporter activity
CFE88_RS00075	COG1136	(ABC) transporter
CFE88_RS00090	COG4640	response to antibiotic
CFE88_RS00095	COG2814	Major facilitator Superfamily
CFE88_RS00105	COG1566	PFAM secretion protein HlyD family protein
CFE88_RS00110	COG2814	Major facilitator Superfamily
CFE88_RS00125	COG0657	acetylesterase activity
CFE88_RS00145	COG1304	FMN binding
CFE88_RS00150	COG0786	glutamate:sodium symporter activity
CFE88_RS00170	COG2094	Belongs to the DNA glycosylase MPG family
CFE88_RS00180	COG1069	ribulokinase activity
CFE88_RS00185	COG2017	converts alpha-aldose to the beta-anomer
CFE88_RS00190	COG2258	MOSC domain
CFE88_RS00195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CFE88_RS00205	COG1266	CAAX protease self-immunity
CFE88_RS00210	COG0010	Belongs to the arginase family
CFE88_RS00215	COG1473	amidohydrolase
CFE88_RS00220	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS00225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFE88_RS00245	COG1737	Transcriptional regulator
CFE88_RS00250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFE88_RS00250	COG1263	PTS System
CFE88_RS00260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFE88_RS00280	COG1113	amino acid transport
CFE88_RS00290	COG1263	PTS System
CFE88_RS00290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFE88_RS00295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFE88_RS00310	COG1266	CAAX protease self-immunity
CFE88_RS00320	COG0483	inositol monophosphate 1-phosphatase activity
CFE88_RS00325	COG1316	TRANSCRIPTIONal
CFE88_RS00355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFE88_RS00360	COG2076	Multidrug Resistance protein
CFE88_RS00365	COG2076	Multidrug Resistance protein
CFE88_RS00370	COG3942	CHAP domain
CFE88_RS00385	COG1757	Na H antiporter
CFE88_RS00390	COG3942	CHAP domain
CFE88_RS00415	COG0829	nickel cation binding
CFE88_RS00420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFE88_RS00425	COG0830	nickel cation binding
CFE88_RS00430	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CFE88_RS00435	COG0804	urea catabolic process
CFE88_RS00440	COG0832	Belongs to the urease beta subunit family
CFE88_RS00445	COG0831	urea catabolic process
CFE88_RS00455	COG1960	acyl-CoA dehydrogenase activity
CFE88_RS00465	COG1268	BioY protein
CFE88_RS00475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFE88_RS00480	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFE88_RS00485	COG4149	molybdate abc transporter
CFE88_RS00490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CFE88_RS00495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFE88_RS00500	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFE88_RS00505	COG0315	cyclic pyranopterin monophosphate synthase activity
CFE88_RS00510	COG0303	'Molybdopterin
CFE88_RS00520	COG0314	molybdopterin synthase activity
CFE88_RS00530	COG0746	molybdenum cofactor guanylyltransferase activity
CFE88_RS00535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFE88_RS00545	COG2814	Major facilitator Superfamily
CFE88_RS00560	COG2348	transferase activity, transferring amino-acyl groups
CFE88_RS00565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFE88_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS00590	COG4975	Glucose uptake
CFE88_RS00595	COG0551	DNA topoisomerase type I activity
CFE88_RS00595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFE88_RS00600	COG2252	PERMEase
CFE88_RS00615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFE88_RS00620	COG0088	Forms part of the polypeptide exit tunnel
CFE88_RS00625	COG0089	rRNA binding
CFE88_RS00630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFE88_RS00635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFE88_RS00640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFE88_RS00645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFE88_RS00650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFE88_RS00660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFE88_RS00665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFE88_RS00670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFE88_RS00675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFE88_RS00680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFE88_RS00685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFE88_RS00690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFE88_RS00695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFE88_RS00700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFE88_RS00705	COG1841	ribosomal large subunit assembly
CFE88_RS00710	COG0200	Binds to the 23S rRNA
CFE88_RS00715	COG0201	protein transport
CFE88_RS00720	COG0563	adenylate kinase activity
CFE88_RS00725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFE88_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFE88_RS00735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFE88_RS00740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFE88_RS00745	COG0202	RNA polymerase activity
CFE88_RS00750	COG0203	ribosomal protein L17
CFE88_RS00755	COG1122	ATPase activity
CFE88_RS00760	COG1122	ATPase activity
CFE88_RS00770	COG0101	tRNA pseudouridine synthase activity
CFE88_RS00775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFE88_RS00780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFE88_RS00785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFE88_RS00790	COG1349	DNA-binding transcription factor activity
CFE88_RS00795	COG0698	ribose 5-phosphate isomerase
CFE88_RS00800	COG0698	ribose 5-phosphate isomerase
CFE88_RS00805	COG1105	Belongs to the carbohydrate kinase PfkB family
CFE88_RS00810	COG3684	Belongs to the aldolase LacD family
CFE88_RS00815	COG1447	Phosphotransferase system cellobiose-specific component IIA
CFE88_RS00820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFE88_RS00820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CFE88_RS00825	COG2723	6-phospho-beta-galactosidase activity
CFE88_RS00835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFE88_RS00840	COG2130	NADP-dependent
CFE88_RS00845	COG0604	alcohol dehydrogenase
CFE88_RS00860	COG1302	Protein conserved in bacteria
CFE88_RS00865	COG4264	IucA IucC family
CFE88_RS00870	COG2814	Major facilitator Superfamily
CFE88_RS00875	COG4264	IucA IucC family
CFE88_RS00880	COG3457	Alanine racemase
CFE88_RS00885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFE88_RS00890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFE88_RS00895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFE88_RS00900	COG3314	Sporulation integral membrane protein YlbJ
CFE88_RS00905	COG2329	Antibiotic biosynthesis monooxygenase
CFE88_RS00915	COG1988	membrane-bound metal-dependent
CFE88_RS00920	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CFE88_RS00940	COG2814	Major facilitator Superfamily
CFE88_RS00945	COG0489	protein tyrosine kinase activity
CFE88_RS00995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CFE88_RS01005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFE88_RS01010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFE88_RS01015	COG0561	phosphatase activity
CFE88_RS01035	COG0640	Transcriptional regulator
CFE88_RS01040	COG0702	epimerase
CFE88_RS01050	COG1482	cell wall glycoprotein biosynthetic process
CFE88_RS01075	COG0783	Belongs to the Dps family
CFE88_RS01080	COG0813	purine-nucleoside phosphorylase activity
CFE88_RS01085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFE88_RS01090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CFE88_RS01095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CFE88_RS01105	COG1854	S-ribosylhomocysteine lyase activity
CFE88_RS01125	COG5146	pantothenate kinase activity
CFE88_RS01135	COG3343	RNA polymerase activity
CFE88_RS01140	COG0504	CTP synthase activity
CFE88_RS01150	COG0191	fructose-bisphosphate aldolase activity
CFE88_RS01155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFE88_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS01165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFE88_RS01170	COG0254	rRNA binding
CFE88_RS01175	COG1435	thymidine kinase activity
CFE88_RS01180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFE88_RS01185	COG2890	protein-(glutamine-N5) methyltransferase activity
CFE88_RS01195	COG0009	L-threonylcarbamoyladenylate synthase
CFE88_RS01200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFE88_RS01205	COG4475	Protein of unknown function (DUF436)
CFE88_RS01210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFE88_RS01215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFE88_RS01220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFE88_RS01230	COG0356	it plays a direct role in the translocation of protons across the membrane
CFE88_RS01240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFE88_RS01245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFE88_RS01250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFE88_RS01255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFE88_RS01260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFE88_RS01265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFE88_RS01275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFE88_RS01280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFE88_RS01290	COG0629	single-stranded DNA binding
CFE88_RS01295	COG1388	LysM domain
CFE88_RS01300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CFE88_RS01310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFE88_RS01315	COG0352	thiamine-phosphate diphosphorylase activity
CFE88_RS01320	COG0706	membrane insertase activity
CFE88_RS01325	COG1418	mRNA catabolic process
CFE88_RS01330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFE88_RS01335	COG1937	Protein conserved in bacteria
CFE88_RS01350	COG0772	Belongs to the SEDS family
CFE88_RS01355	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFE88_RS01360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFE88_RS01365	COG0513	Belongs to the DEAD box helicase family
CFE88_RS01375	COG3428	Bacterial PH domain
CFE88_RS01380	COG3402	PFAM membrane-flanked domain
CFE88_RS01385	COG0736	holo-[acyl-carrier-protein] synthase activity
CFE88_RS01390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFE88_RS01400	COG2337	Toxic component of a toxin-antitoxin (TA) module
CFE88_RS01405	COG2208	phosphoserine phosphatase activity
CFE88_RS01420	COG1191	sigma factor activity
CFE88_RS01425	COG2183	response to ionizing radiation
CFE88_RS01430	COG3091	SprT-like family
CFE88_RS01465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFE88_RS01470	COG0066	3-isopropylmalate dehydratase activity
CFE88_RS01475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFE88_RS01480	COG0473	3-isopropylmalate dehydrogenase activity
CFE88_RS01485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFE88_RS01490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFE88_RS01500	COG0028	Belongs to the TPP enzyme family
CFE88_RS01505	COG0129	dihydroxy-acid dehydratase activity
CFE88_RS01510	COG0802	atpase or kinase
CFE88_RS01515	COG1214	PFAM Peptidase M22, glycoprotease
CFE88_RS01520	COG0456	acetyltransferase
CFE88_RS01525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFE88_RS01530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFE88_RS01535	COG0488	(ABC) transporter
CFE88_RS01540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFE88_RS01550	COG2391	methyltransferase activity
CFE88_RS01555	COG0425	Belongs to the sulfur carrier protein TusA family
CFE88_RS01560	COG0004	ammonium transporteR
CFE88_RS01565	COG1609	Transcriptional regulator
CFE88_RS01575	COG1621	beta-fructofuranosidase activity
CFE88_RS01580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFE88_RS01585	COG3279	Response regulator of the LytR AlgR family
CFE88_RS01590	COG3290	protein histidine kinase activity
CFE88_RS01625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFE88_RS01630	COG0459	protein refolding
CFE88_RS01675	COG1725	Transcriptional regulator
CFE88_RS01680	COG1131	(ABC) transporter
CFE88_RS01690	COG1131	(ABC) transporter
CFE88_RS01735	COG2706	6-phosphogluconolactonase activity
CFE88_RS01740	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS01745	COG1227	inorganic diphosphatase activity
CFE88_RS01750	COG1335	isochorismatase
CFE88_RS01760	COG0077	Prephenate dehydratase
CFE88_RS01770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CFE88_RS01775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFE88_RS01780	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CFE88_RS01790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFE88_RS01795	COG4496	protein, YerC YecD
CFE88_RS01800	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CFE88_RS01805	COG0210	DNA helicase
CFE88_RS01810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFE88_RS01815	COG4851	CamS sex pheromone cAM373 precursor
CFE88_RS01820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFE88_RS01825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFE88_RS01830	COG0154	amidase activity
CFE88_RS01835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFE88_RS01840	COG1597	lipid kinase activity
CFE88_RS01845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFE88_RS01855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFE88_RS01865	COG1528	Iron-storage protein
CFE88_RS01885	COG4129	membrane
CFE88_RS01890	COG0024	Methionine aminopeptidase
CFE88_RS01905	COG4585	Histidine kinase
CFE88_RS01910	COG2197	response regulator
CFE88_RS01915	COG1295	ribonuclease BN
CFE88_RS01925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFE88_RS01930	COG4840	Belongs to the UPF0435 family
CFE88_RS01935	COG2309	aminopeptidase activity
CFE88_RS01940	COG1607	acyl-coa hydrolase
CFE88_RS01945	COG0535	radical SAM domain protein
CFE88_RS01955	COG0693	protein deglycase activity
CFE88_RS01960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFE88_RS01965	COG2137	regulation of response to DNA damage stimulus
CFE88_RS01975	COG1388	LysM domain
CFE88_RS01975	COG1134	teichoic acid transport
CFE88_RS01985	COG1988	membrane-bound metal-dependent
CFE88_RS01995	COG3557	Belongs to the UPF0374 family
CFE88_RS02005	COG4129	membrane
CFE88_RS02010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFE88_RS02015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFE88_RS02020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFE88_RS02025	COG0735	belongs to the Fur family
CFE88_RS02190	COG0765	amino acid transport
CFE88_RS02195	COG1126	abc transporter atp-binding protein
CFE88_RS02200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CFE88_RS02225	COG0114	fumarate hydratase activity
CFE88_RS02235	COG0564	pseudouridine synthase activity
CFE88_RS02240	COG4585	Histidine kinase
CFE88_RS02240	COG2203	Gaf domain
CFE88_RS02245	COG2197	response regulator
CFE88_RS02255	COG4399	Belongs to the UPF0754 family
CFE88_RS02260	COG3679	Belongs to the UPF0342 family
CFE88_RS02265	COG0420	3'-5' exonuclease activity
CFE88_RS02275	COG3481	metal-dependent phosphohydrolase, HD sub domain
CFE88_RS02285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFE88_RS02300	COG0537	adenosine 5'-monophosphoramidase activity
CFE88_RS02305	COG1131	(ABC) transporter
CFE88_RS02310	COG4473	ABC transporter
CFE88_RS02320	COG2329	Antibiotic biosynthesis monooxygenase
CFE88_RS02325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFE88_RS02330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFE88_RS02335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CFE88_RS02405	COG0318	PFAM AMP-dependent synthetase and ligase
CFE88_RS02415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFE88_RS02420	COG0494	nUDIX hydrolase
CFE88_RS02425	COG1506	peptidase
CFE88_RS02430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CFE88_RS02435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFE88_RS02445	COG0656	L-ascorbic acid biosynthetic process
CFE88_RS02450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFE88_RS02455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFE88_RS02465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFE88_RS02495	COG5632	N-Acetylmuramoyl-L-alanine amidase
CFE88_RS02495	COG4193	domain, Protein
CFE88_RS02495	COG3266	domain, Protein
CFE88_RS02505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFE88_RS02505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFE88_RS02515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFE88_RS02515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFE88_RS02520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFE88_RS02525	COG0506	proline dehydrogenase activity
CFE88_RS02530	COG2267	carboxylic ester hydrolase activity
CFE88_RS02540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CFE88_RS02545	COG1242	4 iron, 4 sulfur cluster binding
CFE88_RS02550	COG2814	Major facilitator Superfamily
CFE88_RS02555	COG0495	leucyl-tRNA aminoacylation
CFE88_RS02570	COG2081	HI0933 family
CFE88_RS02575	COG2244	polysaccharide biosynthetic process
CFE88_RS02580	COG1187	pseudouridine synthase activity
CFE88_RS02590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFE88_RS02595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFE88_RS02600	COG0510	thiamine kinase activity
CFE88_RS02605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFE88_RS02615	COG1363	Peptidase, m42
CFE88_RS02620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFE88_RS02625	COG4848	Belongs to the UPF0354 family
CFE88_RS02630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFE88_RS02635	COG1674	ftsk spoiiie
CFE88_RS02640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFE88_RS02645	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CFE88_RS02655	COG1605	Chorismate mutase
CFE88_RS02655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CFE88_RS02660	COG1609	Transcriptional regulator
CFE88_RS02665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CFE88_RS02675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFE88_RS02680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFE88_RS02685	COG0204	Acyl-transferase
CFE88_RS02690	COG1263	PTS System
CFE88_RS02690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFE88_RS02700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFE88_RS02705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFE88_RS02710	COG1764	response to oxidative stress
CFE88_RS02715	COG0584	glycerophosphoryl diester phosphodiesterase
CFE88_RS02720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFE88_RS02730	COG1956	GAF domain-containing protein
CFE88_RS02735	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CFE88_RS02745	COG0301	tRNA thio-modification
CFE88_RS02755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CFE88_RS02760	COG0827	DNA restriction-modification system
CFE88_RS02765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFE88_RS02770	COG0589	response to stress
CFE88_RS02775	COG0686	Belongs to the AlaDH PNT family
CFE88_RS02780	COG0006	proline dipeptidase activity
CFE88_RS02785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFE88_RS02795	COG4109	DRTGG domain
CFE88_RS02800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFE88_RS02805	COG0587	DNA-directed DNA polymerase activity
CFE88_RS02810	COG0281	malic enzyme
CFE88_RS02815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFE88_RS02820	COG0825	malonyl-CoA metabolic process
CFE88_RS02825	COG0205	6-phosphofructokinase activity
CFE88_RS02830	COG0469	pyruvate kinase activity
CFE88_RS02835	COG1113	amino acid transport
CFE88_RS02840	COG0372	Belongs to the citrate synthase family
CFE88_RS02845	COG0538	isocitrate dehydrogenase activity
CFE88_RS02850	COG0745	RESPONSE REGULATOR receiver
CFE88_RS02855	COG5002	protein histidine kinase activity
CFE88_RS02860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFE88_RS02860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFE88_RS02865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFE88_RS02870	COG0237	dephospho-CoA kinase activity
CFE88_RS02880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFE88_RS02885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFE88_RS02890	COG3611	Membrane attachment protein
CFE88_RS02895	COG1484	DNA-dependent DNA replication
CFE88_RS02900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFE88_RS02905	COG0833	amino acid
CFE88_RS02910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFE88_RS02915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFE88_RS02920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFE88_RS02925	COG4112	unkown
CFE88_RS02935	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFE88_RS02940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFE88_RS02945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CFE88_RS02950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFE88_RS02960	COG0181	hydroxymethylbilane synthase activity
CFE88_RS02970	COG0113	porphobilinogen synthase activity
CFE88_RS02975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFE88_RS02985	COG2818	Glycosylase
CFE88_RS02990	COG0525	valine-tRNA ligase activity
CFE88_RS02995	COG0285	dihydrofolate synthase activity
CFE88_RS03005	COG2003	Belongs to the UPF0758 family
CFE88_RS03035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFE88_RS03040	COG2868	ribosomal protein
CFE88_RS03045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFE88_RS03050	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFE88_RS03055	COG4492	Belongs to the UPF0735 family
CFE88_RS03060	COG0632	four-way junction helicase activity
CFE88_RS03065	COG2255	four-way junction helicase activity
CFE88_RS03070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFE88_RS03075	COG0343	queuine tRNA-ribosyltransferase activity
CFE88_RS03080	COG1862	Preprotein translocase
CFE88_RS03085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFE88_RS03085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFE88_RS03090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CFE88_RS03090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFE88_RS03095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFE88_RS03100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFE88_RS03105	COG1490	D-aminoacyl-tRNA deacylase activity
CFE88_RS03110	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFE88_RS03115	COG0124	histidyl-tRNA synthetase
CFE88_RS03120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFE88_RS03135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CFE88_RS03140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFE88_RS03145	COG1959	2 iron, 2 sulfur cluster binding
CFE88_RS03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFE88_RS03160	COG1104	cysteine desulfurase activity
CFE88_RS03165	COG0482	sulfurtransferase activity
CFE88_RS03175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFE88_RS03180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFE88_RS03185	COG4472	Bacterial protein of unknown function (DUF965)
CFE88_RS03190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFE88_RS03195	COG3906	Belongs to the UPF0473 family
CFE88_RS03205	COG0826	peptidase U32
CFE88_RS03210	COG0826	peptidase U32
CFE88_RS03215	COG0572	uridine kinase
CFE88_RS03220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFE88_RS03225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFE88_RS03230	COG1984	allophanate hydrolase subunit 2
CFE88_RS03235	COG0511	ligase activity, forming carbon-carbon bonds
CFE88_RS03240	COG0439	Biotin carboxylase
CFE88_RS03245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFE88_RS03250	COG1914	H( )-stimulated, divalent metal cation uptake system
CFE88_RS03255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFE88_RS03260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CFE88_RS03265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CFE88_RS03270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFE88_RS03275	COG1534	Rna-binding protein
CFE88_RS03280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFE88_RS03285	COG1713	HD superfamily hydrolase involved in NAD metabolism
CFE88_RS03290	COG0799	negative regulation of ribosome biogenesis
CFE88_RS03295	COG2226	methyltransferase
CFE88_RS03305	COG2131	deaminase
CFE88_RS03310	COG2333	competence protein COMEC
CFE88_RS03310	COG0658	competence protein
CFE88_RS03315	COG1466	dna polymerase III delta subunit
CFE88_RS03325	COG0268	Binds directly to 16S ribosomal RNA
CFE88_RS03330	COG0481	GTPase activity
CFE88_RS03335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFE88_RS03340	COG1420	regulation of RNA biosynthetic process
CFE88_RS03345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFE88_RS03350	COG0443	Heat shock 70 kDa protein
CFE88_RS03355	COG0484	heat shock protein binding
CFE88_RS03360	COG2264	protein methyltransferase activity
CFE88_RS03365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CFE88_RS03370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFE88_RS03380	COG1030	water channel activity
CFE88_RS03385	COG4864	UPF0365 protein
CFE88_RS03395	COG1702	phosphate starvation-inducible protein PhoH
CFE88_RS03400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFE88_RS03405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFE88_RS03410	COG0295	cytidine deaminase activity
CFE88_RS03415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFE88_RS03420	COG1381	Involved in DNA repair and RecF pathway recombination
CFE88_RS03425	COG0423	glycine-tRNA ligase activity
CFE88_RS03430	COG0517	IMP dehydrogenase activity
CFE88_RS03435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFE88_RS03440	COG0358	DNA primase activity
CFE88_RS03445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFE88_RS03450	COG2384	SAM-dependent methyltransferase
CFE88_RS03455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFE88_RS03460	COG0513	Belongs to the DEAD box helicase family
CFE88_RS03465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFE88_RS03470	COG1121	(ABC) transporter
CFE88_RS03475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFE88_RS03480	COG0735	belongs to the Fur family
CFE88_RS03485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CFE88_RS03495	COG0768	penicillin binding
CFE88_RS03500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFE88_RS03505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFE88_RS03510	COG0457	Tetratricopeptide repeat
CFE88_RS03510	COG0705	Rhomboid family
CFE88_RS03515	COG4483	Protein conserved in bacteria
CFE88_RS03520	COG1940	carbohydrate kinase activity
CFE88_RS03525	COG0011	TIGRFAM Protein of
CFE88_RS03530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFE88_RS03535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFE88_RS03540	COG1459	type II secretion system
CFE88_RS03545	COG4537	Required for transformation and DNA binding
CFE88_RS03570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFE88_RS03575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFE88_RS03580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFE88_RS03585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFE88_RS03595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFE88_RS03600	COG0095	Lipoate-protein ligase
CFE88_RS03615	COG0006	proline dipeptidase activity
CFE88_RS03620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFE88_RS03625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFE88_RS03630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CFE88_RS03635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFE88_RS03640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFE88_RS03645	COG0511	ligase activity, forming carbon-carbon bonds
CFE88_RS03650	COG0439	Biotin carboxylase
CFE88_RS03655	COG1302	Protein conserved in bacteria
CFE88_RS03660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFE88_RS03665	COG1570	exodeoxyribonuclease VII activity
CFE88_RS03670	COG1722	exodeoxyribonuclease VII activity
CFE88_RS03680	COG1438	arginine binding
CFE88_RS03685	COG0497	DNA recombination
CFE88_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFE88_RS03695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFE88_RS03700	COG0022	dehydrogenase e1 component
CFE88_RS03705	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFE88_RS03715	COG4129	membrane
CFE88_RS03720	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFE88_RS03725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CFE88_RS03730	COG0366	Alpha amylase catalytic
CFE88_RS03740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFE88_RS03745	COG1234	tRNA 3'-trailer cleavage
CFE88_RS03750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFE88_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS03760	COG0667	Aldo Keto reductase
CFE88_RS03765	COG0494	nUDIX hydrolase
CFE88_RS03770	COG0735	belongs to the Fur family
CFE88_RS03775	COG4974	Belongs to the 'phage' integrase family
CFE88_RS03780	COG1547	Domain of unknown function (DUF309)
CFE88_RS03785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFE88_RS03790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFE88_RS03795	COG1187	pseudouridine synthase activity
CFE88_RS03800	COG0745	RESPONSE REGULATOR receiver
CFE88_RS03820	COG1141	Ferredoxin
CFE88_RS03830	COG0514	ATP-dependent DNA helicase (RecQ)
CFE88_RS03835	COG1388	LysM domain
CFE88_RS03840	COG0492	ferredoxin-NADP+ reductase activity
CFE88_RS03845	COG0252	asparaginase activity
CFE88_RS03850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFE88_RS03855	COG0539	negative regulation of cytoplasmic translation
CFE88_RS03860	COG1160	GTP binding
CFE88_RS03865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFE88_RS03880	COG2226	methyltransferase
CFE88_RS03890	COG0105	UTP biosynthetic process
CFE88_RS03895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFE88_RS03900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFE88_RS03905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFE88_RS03915	COG5582	Belongs to the UPF0302 family
CFE88_RS03920	COG4347	Protein of unknown function (DUF1405)
CFE88_RS03925	COG2738	Putative neutral zinc metallopeptidase
CFE88_RS03930	COG1694	Mazg nucleotide pyrophosphohydrolase
CFE88_RS03935	COG0438	transferase activity, transferring glycosyl groups
CFE88_RS03940	COG0617	tRNA 3'-terminal CCA addition
CFE88_RS03945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CFE88_RS03945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CFE88_RS03950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFE88_RS03950	COG1199	ATP-dependent helicase activity
CFE88_RS03955	COG0017	Asparaginyl-tRNA synthetase
CFE88_RS03960	COG3935	DnaD domain protein
CFE88_RS03965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFE88_RS03975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFE88_RS03975	COG4499	WXG100 protein secretion system (Wss), protein YukC
CFE88_RS03980	COG3331	DNA recombination
CFE88_RS03990	COG4474	Belongs to the UPF0398 family
CFE88_RS03995	COG3599	regulation of cell shape
CFE88_RS04005	COG0116	Belongs to the methyltransferase superfamily
CFE88_RS04015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFE88_RS04020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFE88_RS04025	COG1511	domain protein
CFE88_RS04025	COG1196	nuclear chromosome segregation
CFE88_RS04025	COG4372	Transposase
CFE88_RS04035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CFE88_RS04045	COG1413	lyase activity
CFE88_RS04090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFE88_RS04095	COG2190	(PTS) system
CFE88_RS04100	COG4479	Belongs to the UPF0346 family
CFE88_RS04105	COG0793	Belongs to the peptidase S41A family
CFE88_RS04120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFE88_RS04125	COG0671	phosphoesterase, PA-phosphatase related
CFE88_RS04135	COG0745	RESPONSE REGULATOR receiver
CFE88_RS04140	COG5002	protein histidine kinase activity
CFE88_RS04150	COG0567	Dehydrogenase, E1 component
CFE88_RS04155	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFE88_RS04160	COG1131	(ABC) transporter
CFE88_RS04185	COG0714	Associated with various cellular activities
CFE88_RS04190	COG4548	von Willebrand factor, type A
CFE88_RS04195	COG1114	Component of the transport system for branched-chain amino acids
CFE88_RS04200	COG3853	Toxic anion resistance protein (TelA)
CFE88_RS04210	COG1254	Belongs to the acylphosphatase family
CFE88_RS04220	COG1278	Cold shock
CFE88_RS04245	COG1473	amidohydrolase
CFE88_RS04250	COG2171	N-acyltransferase activity
CFE88_RS04255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFE88_RS04260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFE88_RS04265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFE88_RS04270	COG0527	aspartate kinase activity
CFE88_RS04275	COG0488	(ABC) transporter
CFE88_RS04280	COG2996	Protein conserved in bacteria
CFE88_RS04285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFE88_RS04290	COG0573	inorganic phosphate transmembrane transporter activity
CFE88_RS04295	COG0581	inorganic phosphate transmembrane transporter activity
CFE88_RS04300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFE88_RS04305	COG0704	Plays a role in the regulation of phosphate uptake
CFE88_RS04310	COG1164	Oligoendopeptidase f
CFE88_RS04340	COG4607	ABC-type enterochelin transport system periplasmic component
CFE88_RS04350	COG2348	transferase activity, transferring amino-acyl groups
CFE88_RS04355	COG2348	transferase activity, transferring amino-acyl groups
CFE88_RS04370	COG0159	tryptophan synthase activity
CFE88_RS04375	COG0133	tryptophan synthase activity
CFE88_RS04380	COG0135	phosphoribosylanthranilate isomerase activity
CFE88_RS04385	COG0134	indole-3-glycerol-phosphate synthase activity
CFE88_RS04390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFE88_RS04400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFE88_RS04405	COG0287	Prephenate dehydrogenase
CFE88_RS04410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFE88_RS04415	COG1942	4-Oxalocrotonate Tautomerase
CFE88_RS04430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CFE88_RS04430	COG0392	lysyltransferase activity
CFE88_RS04435	COG0628	permease
CFE88_RS04440	COG3711	transcriptional antiterminator
CFE88_RS04445	COG1115	amino acid carrier protein
CFE88_RS04450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFE88_RS04455	COG0187	DNA topoisomerase II activity
CFE88_RS04460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFE88_RS04465	COG4841	protein insertion into membrane
CFE88_RS04470	COG0824	Thioesterase
CFE88_RS04475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFE88_RS04480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFE88_RS04485	COG1970	mechanosensitive ion channel activity
CFE88_RS04490	COG0419	ATPase involved in DNA repair
CFE88_RS04495	COG0420	3'-5' exonuclease activity
CFE88_RS04500	COG4846	Membrane protein involved in cytochrome C biogenesis
CFE88_RS04510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFE88_RS04515	COG4224	UPF0291 protein
CFE88_RS04525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFE88_RS04540	COG0516	GMP reductase activity
CFE88_RS04545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFE88_RS04560	COG0833	amino acid
CFE88_RS04575	COG0083	homoserine kinase activity
CFE88_RS04580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFE88_RS04585	COG0460	homoserine dehydrogenase
CFE88_RS04590	COG0527	aspartate kinase activity
CFE88_RS04610	COG1525	nuclease
CFE88_RS04620	COG2197	response regulator
CFE88_RS04635	COG1131	(ABC) transporter
CFE88_RS04640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CFE88_RS04705	COG4824	toxin secretion phage lysis holin
CFE88_RS04805	COG1783	phage Terminase large subunit
CFE88_RS04900	COG0174	glutamine synthetase
CFE88_RS04905	COG0789	Transcriptional regulator
CFE88_RS04910	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CFE88_RS04915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFE88_RS04920	COG0386	Belongs to the glutathione peroxidase family
CFE88_RS04925	COG1923	regulation of RNA biosynthetic process
CFE88_RS04930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFE88_RS04940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFE88_RS04945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFE88_RS04950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFE88_RS04955	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CFE88_RS04960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CFE88_RS04965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CFE88_RS04975	COG4550	Control of competence regulator ComK, YlbF/YmcA
CFE88_RS04980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFE88_RS04990	COG4195	phage-related replication protein
CFE88_RS04995	COG1013	pyruvate-flavodoxin oxidoreductase activity
CFE88_RS05000	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFE88_RS05000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFE88_RS05005	COG1692	metallophosphoesterase
CFE88_RS05015	COG1418	mRNA catabolic process
CFE88_RS05020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFE88_RS05025	COG1058	Belongs to the CinA family
CFE88_RS05025	COG1546	Belongs to the CinA family
CFE88_RS05030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFE88_RS05045	COG0300	oxidoreductase activity
CFE88_RS05050	COG0612	Peptidase, M16
CFE88_RS05055	COG0612	Peptidase, M16
CFE88_RS05060	COG2188	Transcriptional regulator
CFE88_RS05065	COG1674	ftsk spoiiie
CFE88_RS05070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFE88_RS05075	COG1185	polyribonucleotide nucleotidyltransferase activity
CFE88_RS05080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFE88_RS05085	COG0196	riboflavin kinase activity
CFE88_RS05090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFE88_RS05095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFE88_RS05100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFE88_RS05105	COG1358	cellular component organization or biogenesis
CFE88_RS05110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CFE88_RS05115	COG0195	Participates in both transcription termination and antitermination
CFE88_RS05120	COG0779	Required for maturation of 30S ribosomal subunits
CFE88_RS05125	COG2176	DNA-directed DNA polymerase activity
CFE88_RS05130	COG0442	prolyl-tRNA aminoacylation
CFE88_RS05140	COG4589	Belongs to the CDS family
CFE88_RS05145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFE88_RS05150	COG0233	cytoplasmic translational termination
CFE88_RS05155	COG0528	UMP kinase activity
CFE88_RS05160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFE88_RS05165	COG0052	Belongs to the universal ribosomal protein uS2 family
CFE88_RS05170	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CFE88_RS05175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFE88_RS05180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFE88_RS05185	COG4974	Belongs to the 'phage' integrase family
CFE88_RS05190	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CFE88_RS05195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFE88_RS05200	COG0758	DNA mediated transformation
CFE88_RS05205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFE88_RS05210	COG0045	succinate-CoA ligase (ADP-forming) activity
CFE88_RS05215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFE88_RS05230	COG4485	Bacterial membrane protein, YfhO
CFE88_RS05240	COG0335	large ribosomal subunit rRNA binding
CFE88_RS05245	COG0336	Belongs to the RNA methyltransferase TrmD family
CFE88_RS05250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFE88_RS05255	COG0228	four-way junction DNA binding
CFE88_RS05260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFE88_RS05265	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CFE88_RS05270	COG0552	protein localization to endoplasmic reticulum
CFE88_RS05275	COG1196	nuclear chromosome segregation
CFE88_RS05280	COG0571	ribonuclease III activity
CFE88_RS05285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFE88_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS05300	COG0416	fatty acid biosynthetic process
CFE88_RS05305	COG1349	DNA-binding transcription factor activity
CFE88_RS05310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFE88_RS05315	COG1461	Dihydroxyacetone kinase
CFE88_RS05320	COG1302	Protein conserved in bacteria
CFE88_RS05325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFE88_RS05335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFE88_RS05340	COG1162	GTPase activity
CFE88_RS05350	COG0631	protein serine/threonine phosphatase activity
CFE88_RS05355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFE88_RS05360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFE88_RS05360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CFE88_RS05365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFE88_RS05370	COG0242	peptide deformylase activity
CFE88_RS05380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFE88_RS05385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CFE88_RS05390	COG1758	RNA polymerase activity
CFE88_RS05395	COG0194	GDP metabolic process
CFE88_RS05415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFE88_RS05420	COG0284	orotidine-5'-phosphate decarboxylase activity
CFE88_RS05425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFE88_RS05430	COG0505	Belongs to the CarA family
CFE88_RS05435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFE88_RS05440	COG0540	Belongs to the ATCase OTCase family
CFE88_RS05445	COG2233	PERMEase
CFE88_RS05455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFE88_RS05460	COG0564	pseudouridine synthase activity
CFE88_RS05465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFE88_RS05470	COG1388	LysM domain
CFE88_RS05470	COG3942	CHAP domain
CFE88_RS05480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFE88_RS05485	COG3599	regulation of cell shape
CFE88_RS05495	COG0762	integral membrane protein
CFE88_RS05500	COG1799	cell septum assembly
CFE88_RS05505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFE88_RS05510	COG1496	oxidoreductase activity
CFE88_RS05515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFE88_RS05520	COG0849	cell division
CFE88_RS05525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFE88_RS05530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFE88_RS05535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFE88_RS05540	COG0768	penicillin binding
CFE88_RS05545	COG4839	cell division protein FtsL
CFE88_RS05550	COG0275	rRNA processing
CFE88_RS05555	COG2001	Belongs to the MraZ family
CFE88_RS05560	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CFE88_RS05565	COG0454	-acetyltransferase
CFE88_RS05570	COG1011	Hydrolase
CFE88_RS05605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFE88_RS05610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFE88_RS05615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFE88_RS05620	COG1053	succinate dehydrogenase
CFE88_RS05625	COG2009	succinate dehydrogenase
CFE88_RS05635	COG0322	excinuclease ABC activity
CFE88_RS05640	COG3118	belongs to the thioredoxin family
CFE88_RS05645	COG1193	negative regulation of DNA recombination
CFE88_RS05650	COG1796	DNA polymerase
CFE88_RS05650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFE88_RS05660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CFE88_RS05665	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFE88_RS05670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFE88_RS05670	COG0072	phenylalanine-tRNA ligase activity
CFE88_RS05675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFE88_RS05680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFE88_RS05695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFE88_RS05710	COG1323	Belongs to the UPF0348 family
CFE88_RS05715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFE88_RS05720	COG0742	ribosomal rna small subunit methyltransferase
CFE88_RS05730	COG4471	UPF0298 protein
CFE88_RS05740	COG0584	glycerophosphoryl diester phosphodiesterase
CFE88_RS05745	COG3679	Belongs to the UPF0342 family
CFE88_RS05750	COG2340	Cysteine-rich secretory protein family
CFE88_RS05760	COG0109	protoheme IX farnesyltransferase activity
CFE88_RS05765	COG1612	heme a metabolic process
CFE88_RS05775	COG0772	Belongs to the SEDS family
CFE88_RS05780	COG4838	Belongs to the UPF0358 family
CFE88_RS05785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFE88_RS05790	COG4896	Protein conserved in bacteria
CFE88_RS05795	COG1217	gtp-binding protein TYPA
CFE88_RS05805	COG0483	inositol monophosphate 1-phosphatase activity
CFE88_RS05810	COG4493	Belongs to the UPF0637 family
CFE88_RS05815	COG1914	H( )-stimulated, divalent metal cation uptake system
CFE88_RS05840	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFE88_RS05845	COG3842	ATPase activity
CFE88_RS05855	COG4476	Belongs to the UPF0223 family
CFE88_RS05865	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFE88_RS05870	COG0022	dehydrogenase e1 component
CFE88_RS05875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFE88_RS05885	COG0242	peptide deformylase activity
CFE88_RS05900	COG5503	Protein of unknown function (DUF1447)
CFE88_RS05905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFE88_RS05910	COG0569	domain protein
CFE88_RS05915	COG1294	oxidase, subunit
CFE88_RS05920	COG1271	oxidase subunit
CFE88_RS05930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFE88_RS05935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFE88_RS05945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CFE88_RS05960	COG4716	Myosin-crossreactive antigen
CFE88_RS05970	COG4172	Belongs to the ABC transporter superfamily
CFE88_RS05975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CFE88_RS05980	COG0151	Belongs to the GarS family
CFE88_RS05985	COG0138	bifunctional purine biosynthesis protein purh
CFE88_RS05990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CFE88_RS05995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFE88_RS06000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CFE88_RS06005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFE88_RS06010	COG0047	phosphoribosylformylglycinamidine synthase activity
CFE88_RS06015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFE88_RS06020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFE88_RS06025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CFE88_RS06030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFE88_RS06035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFE88_RS06045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFE88_RS06050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFE88_RS06055	COG1845	cytochrome c oxidase, subunit III
CFE88_RS06060	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CFE88_RS06075	COG1316	TRANSCRIPTIONal
CFE88_RS06100	COG3594	Acyltransferase
CFE88_RS06105	COG0436	Aminotransferase
CFE88_RS06120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFE88_RS06130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFE88_RS06135	COG1169	isochorismate synthase
CFE88_RS06145	COG1575	Belongs to the MenA family. Type 1 subfamily
CFE88_RS06155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFE88_RS06165	COG2314	TM2 domain
CFE88_RS06180	COG1279	arginine transmembrane transporter activity
CFE88_RS06235	COG4873	Protein conserved in bacteria
CFE88_RS06245	COG0737	Belongs to the 5'-nucleotidase family
CFE88_RS06250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFE88_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFE88_RS06260	COG0861	Integral membrane protein TerC family
CFE88_RS06265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CFE88_RS06275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFE88_RS06280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFE88_RS06285	COG2814	Major facilitator Superfamily
CFE88_RS06290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CFE88_RS06295	COG2382	esterase
CFE88_RS06300	COG0628	permease
CFE88_RS06415	COG1733	regulation of RNA biosynthetic process
CFE88_RS06430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFE88_RS06435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFE88_RS06440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFE88_RS06520	COG0569	domain protein
CFE88_RS06520	COG0475	glutathione-regulated potassium exporter activity
CFE88_RS06525	COG2239	Acts as a magnesium transporter
CFE88_RS06530	COG0564	pseudouridine synthase activity
CFE88_RS06535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFE88_RS06540	COG2357	RelA SpoT domain protein
CFE88_RS06555	COG2346	COG2346, Truncated hemoglobins
CFE88_RS06560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFE88_RS06575	COG1164	Oligoendopeptidase f
CFE88_RS06585	COG4862	establishment of competence for transformation
CFE88_RS06590	COG1393	Belongs to the ArsC family
CFE88_RS06595	COG0180	Tryptophanyl-tRNA synthetase
CFE88_RS06600	COG4166	transmembrane transport
CFE88_RS06605	COG4608	Belongs to the ABC transporter superfamily
CFE88_RS06610	COG0444	Belongs to the ABC transporter superfamily
CFE88_RS06615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFE88_RS06620	COG0601	transmembrane transport
CFE88_RS06635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFE88_RS06645	COG0542	response to heat
CFE88_RS06660	COG0561	phosphatase activity
CFE88_RS06665	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFE88_RS06675	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFE88_RS06680	COG1074	ATP-dependent DNA helicase activity
CFE88_RS06685	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CFE88_RS06700	COG0398	Pfam SNARE associated Golgi protein
CFE88_RS06710	COG0166	Belongs to the GPI family
CFE88_RS06715	COG0137	argininosuccinate synthase activity
CFE88_RS06720	COG0165	Argininosuccinate lyase
CFE88_RS06725	COG0584	glycerophosphoryl diester phosphodiesterase
CFE88_RS06735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFE88_RS06740	COG1902	pentaerythritol trinitrate reductase activity
CFE88_RS06745	COG1098	S1 RNA binding domain
CFE88_RS06750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFE88_RS06760	COG2111	Na H antiporter
CFE88_RS06760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFE88_RS06765	COG2111	Na H antiporter
CFE88_RS06770	COG1006	Multisubunit Na H antiporter MnhC subunit
CFE88_RS06775	COG0651	ATP synthesis coupled electron transport
CFE88_RS06780	COG1863	multisubunit Na H antiporter MnhE subunit
CFE88_RS06785	COG2212	antiporter activity
CFE88_RS06790	COG1320	monovalent cation:proton antiporter activity
CFE88_RS06800	COG2050	protein possibly involved in aromatic compounds catabolism
CFE88_RS06805	COG2056	Na+-H+ antiporter family
CFE88_RS06810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFE88_RS06815	COG1252	NADH dehydrogenase
CFE88_RS06820	COG0316	Belongs to the HesB IscA family
CFE88_RS06825	COG4844	belongs to the
CFE88_RS06830	COG1252	NADH dehydrogenase
CFE88_RS06835	COG4837	Protein of unknown function (DUF1462)
CFE88_RS06840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CFE88_RS06845	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CFE88_RS06850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFE88_RS06855	COG1696	Membrane protein involved in D-alanine export
CFE88_RS06860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFE88_RS06875	COG0647	UMP catabolic process
CFE88_RS06880	COG2445	Protein of unknown function DUF86
CFE88_RS06895	COG4470	Protein conserved in bacteria
CFE88_RS06900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFE88_RS06905	COG0737	Belongs to the 5'-nucleotidase family
CFE88_RS06910	COG0730	response to heat
CFE88_RS06915	COG1801	Protein of unknown function DUF72
CFE88_RS06930	COG1253	flavin adenine dinucleotide binding
CFE88_RS06940	COG0719	Fe-S assembly protein
CFE88_RS06945	COG0822	iron-sulfur transferase activity
CFE88_RS06950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFE88_RS06955	COG0719	Fe-S assembly protein
CFE88_RS06960	COG0396	ATPase activity
CFE88_RS06970	COG3237	CsbD-like
CFE88_RS06980	COG1464	Belongs to the NlpA lipoprotein family
CFE88_RS06985	COG2011	ABC-type metal ion transport system permease component
CFE88_RS06990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFE88_RS07000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFE88_RS07010	COG0509	glycine decarboxylation via glycine cleavage system
CFE88_RS07015	COG1393	Belongs to the ArsC family
CFE88_RS07020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFE88_RS07030	COG0710	3-dehydroquinate dehydratase activity
CFE88_RS07035	COG1764	response to oxidative stress
CFE88_RS07085	COG4195	phage-related replication protein
CFE88_RS07100	COG1278	Cold shock
CFE88_RS07135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFE88_RS07175	COG3728	DNA packaging
CFE88_RS07175	COG5484	DNA packaging
CFE88_RS07240	COG0582	viral genome integration into host DNA
CFE88_RS07250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFE88_RS07255	COG0557	exoribonuclease II activity
CFE88_RS07260	COG1647	Serine aminopeptidase, S33
CFE88_RS07265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFE88_RS07275	COG0148	phosphopyruvate hydratase activity
CFE88_RS07280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CFE88_RS07285	COG0149	triose-phosphate isomerase activity
CFE88_RS07290	COG0126	phosphoglycerate kinase activity
CFE88_RS07295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFE88_RS07315	COG1090	epimerase
CFE88_RS07330	COG0740	serine-type endopeptidase activity
CFE88_RS07340	COG1481	regulation of sporulation
CFE88_RS07345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFE88_RS07350	COG1660	Displays ATPase and GTPase activities
CFE88_RS07355	COG0492	ferredoxin-NADP+ reductase activity
CFE88_RS07370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFE88_RS07375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CFE88_RS07380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFE88_RS07385	COG0556	nucleotide-excision repair
CFE88_RS07405	COG3942	CHAP domain
CFE88_RS07405	COG1388	LysM domain
CFE88_RS07410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFE88_RS07415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFE88_RS07420	COG0653	protein targeting
CFE88_RS07425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CFE88_RS07430	COG1040	competence protein
CFE88_RS07435	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CFE88_RS07445	COG1739	Uncharacterized protein family UPF0029
CFE88_RS07450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFE88_RS07455	COG2199	diguanylate cyclase activity
CFE88_RS07470	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFE88_RS07475	COG1929	Belongs to the glycerate kinase type-1 family
CFE88_RS07495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFE88_RS07510	COG4604	ABC transporter, ATP-binding protein
CFE88_RS07515	COG4605	iron ion homeostasis
CFE88_RS07520	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFE88_RS07530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFE88_RS07535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFE88_RS07540	COG1780	Probably involved in ribonucleotide reductase function
CFE88_RS07550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFE88_RS07555	COG3104	oligopeptide transport
CFE88_RS07560	COG1597	lipid kinase activity
CFE88_RS07565	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS07565	COG1454	alcohol dehydrogenase
CFE88_RS07570	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CFE88_RS07580	COG1174	glycine betaine transport
CFE88_RS07585	COG1125	glycine betaine transport
CFE88_RS07585	COG0517	IMP dehydrogenase activity
CFE88_RS07590	COG0514	ATP-dependent DNA helicase (RecQ)
CFE88_RS07595	COG0488	(ABC) transporter
CFE88_RS07610	COG1368	sulfuric ester hydrolase activity
CFE88_RS07620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFE88_RS07635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFE88_RS07645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CFE88_RS07650	COG0720	synthase
CFE88_RS07655	COG0602	queuosine metabolic process
CFE88_RS07680	COG0745	RESPONSE REGULATOR receiver
CFE88_RS07685	COG5002	protein histidine kinase activity
CFE88_RS07690	COG0463	Glycosyl transferase, family 2
CFE88_RS07695	COG0656	L-ascorbic acid biosynthetic process
CFE88_RS07700	COG1253	flavin adenine dinucleotide binding
CFE88_RS07705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFE88_RS07715	COG1733	regulation of RNA biosynthetic process
CFE88_RS07730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFE88_RS07730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFE88_RS07730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFE88_RS07735	COG1105	Belongs to the carbohydrate kinase PfkB family
CFE88_RS07740	COG1349	DNA-binding transcription factor activity
CFE88_RS07750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFE88_RS07775	COG0415	Belongs to the DNA photolyase family
CFE88_RS07780	COG0471	metal ion transport
CFE88_RS07785	COG0039	L-malate dehydrogenase activity
CFE88_RS07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFE88_RS07815	COG4988	ABC transporter
CFE88_RS07820	COG1968	undecaprenyl-diphosphatase activity
CFE88_RS07835	COG1671	Belongs to the UPF0178 family
CFE88_RS07840	COG1611	Belongs to the LOG family
CFE88_RS07865	COG2839	Protein conserved in bacteria
CFE88_RS07870	COG2814	Major facilitator Superfamily
CFE88_RS07875	COG0583	DNA-binding transcription factor activity
CFE88_RS07895	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CFE88_RS07905	COG0217	transcriptional regulatory protein
CFE88_RS07925	COG3942	CHAP domain
CFE88_RS07925	COG1388	LysM domain
CFE88_RS07930	COG0306	phosphate transporter
CFE88_RS07935	COG1392	Phosphate transport regulator
CFE88_RS07940	COG0577	efflux transmembrane transporter activity
CFE88_RS07945	COG1136	(ABC) transporter
CFE88_RS07950	COG2205	protein histidine kinase activity
CFE88_RS07955	COG0745	RESPONSE REGULATOR receiver
CFE88_RS07960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFE88_RS07975	COG3949	Membrane
CFE88_RS07985	COG1120	ATPase activity
CFE88_RS07990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFE88_RS07995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFE88_RS08000	COG1132	(ABC) transporter
CFE88_RS08005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFE88_RS08015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFE88_RS08020	COG1682	transport, permease protein
CFE88_RS08025	COG1134	teichoic acid transport
CFE88_RS08030	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CFE88_RS08040	COG1321	iron dependent repressor
CFE88_RS08045	COG1121	(ABC) transporter
CFE88_RS08050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFE88_RS08055	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFE88_RS08065	COG1320	monovalent cation:proton antiporter activity
CFE88_RS08070	COG2212	antiporter activity
CFE88_RS08075	COG1863	multisubunit Na H antiporter MnhE subunit
CFE88_RS08080	COG0651	ATP synthesis coupled electron transport
CFE88_RS08085	COG1006	Multisubunit Na H antiporter MnhC subunit
CFE88_RS08090	COG2111	Na H antiporter
CFE88_RS08095	COG2111	Na H antiporter
CFE88_RS08095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFE88_RS08135	COG0596	Alpha beta hydrolase
CFE88_RS08155	COG0546	phosphoglycolate phosphatase activity
CFE88_RS08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFE88_RS08165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFE88_RS08180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFE88_RS08185	COG0018	arginyl-trna synthetase
CFE88_RS08205	COG1064	alcohol dehydrogenase
CFE88_RS08210	COG3875	lactate racemase activity
CFE88_RS08215	COG1606	tRNA processing
CFE88_RS08220	COG1691	(AIR) carboxylase
CFE88_RS08225	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CFE88_RS08235	COG1078	dGTPase activity
CFE88_RS08255	COG2113	Glycine betaine
CFE88_RS08260	COG2409	Drug exporters of the RND superfamily
CFE88_RS08265	COG0667	Aldo Keto reductase
CFE88_RS08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFE88_RS08280	COG4844	belongs to the
CFE88_RS08300	COG0095	Lipoate-protein ligase
CFE88_RS08305	COG0280	phosphate acetyltransferase
CFE88_RS08310	COG3253	May function as heme-dependent peroxidase
CFE88_RS08325	COG0531	amino acid
CFE88_RS08330	COG2363	Small membrane protein
CFE88_RS08340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFE88_RS08350	COG0351	phosphomethylpyrimidine kinase
CFE88_RS08360	COG0477	Major facilitator Superfamily
CFE88_RS08375	COG0183	Belongs to the thiolase family
CFE88_RS08380	COG0318	PFAM AMP-dependent synthetase and ligase
CFE88_RS08390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CFE88_RS08395	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CFE88_RS08400	COG0363	glucosamine-6-phosphate deaminase activity
CFE88_RS08410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFE88_RS08415	COG1469	GTP cyclohydrolase I activity
CFE88_RS08425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFE88_RS08430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFE88_RS08445	COG0431	NADPH-dependent FMN reductase
CFE88_RS08450	COG0561	phosphatase activity
CFE88_RS08460	COG1428	Deoxynucleoside kinase
CFE88_RS08465	COG1428	Deoxynucleoside kinase
CFE88_RS08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFE88_RS08485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFE88_RS08490	COG1063	alcohol dehydrogenase
CFE88_RS08495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFE88_RS08500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFE88_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFE88_RS08525	COG1473	amidohydrolase
CFE88_RS08530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFE88_RS08535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFE88_RS08545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFE88_RS08555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFE88_RS08560	COG0085	RNA polymerase activity
CFE88_RS08565	COG2813	Specifically methylates the guanine in position
CFE88_RS08570	COG0222	ribosome binding
CFE88_RS08575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFE88_RS08585	COG0081	regulation of translation
CFE88_RS08590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFE88_RS08595	COG0250	Participates in transcription elongation, termination and antitermination
CFE88_RS08600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFE88_RS08605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFE88_RS08615	COG3688	RNA-binding protein containing a PIN domain
CFE88_RS08620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFE88_RS08625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CFE88_RS08630	COG0215	cysteine-tRNA ligase activity
CFE88_RS08635	COG1045	serine acetyltransferase
CFE88_RS08640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFE88_RS08645	COG4956	integral membrane protein (PIN domain superfamily)
CFE88_RS08650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFE88_RS08655	COG0542	response to heat
CFE88_RS08660	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CFE88_RS08665	COG3880	PFAM UvrB UvrC protein
CFE88_RS08670	COG4463	regulation of RNA biosynthetic process
CFE88_RS08675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CFE88_RS08685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFE88_RS08690	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFE88_RS08695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFE88_RS08780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFE88_RS08785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFE88_RS08790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFE88_RS08795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFE88_RS08800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFE88_RS08805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CFE88_RS08810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFE88_RS08815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CFE88_RS08820	COG0037	tRNA processing
CFE88_RS08825	COG1098	S1 RNA binding domain
CFE88_RS08835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFE88_RS08840	COG3956	TIGRFAM MazG family protein
CFE88_RS08845	COG2244	polysaccharide biosynthetic process
CFE88_RS08850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFE88_RS08855	COG0193	aminoacyl-tRNA hydrolase activity
CFE88_RS08860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFE88_RS08865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFE88_RS08870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFE88_RS08875	COG2088	sporulation resulting in formation of a cellular spore
CFE88_RS08880	COG0251	oxidation-reduction process
CFE88_RS08885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFE88_RS08890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFE88_RS08895	COG4466	Protein conserved in bacteria
CFE88_RS08900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFE88_RS08905	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CFE88_RS08910	COG0084	hydrolase, TatD family'
CFE88_RS08915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFE88_RS08915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFE88_RS08920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFE88_RS08925	COG2827	Endonuclease containing a URI domain
CFE88_RS08930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CFE88_RS08935	COG4467	Involved in initiation control of chromosome replication
CFE88_RS08940	COG1774	PSP1 C-terminal conserved region
CFE88_RS08945	COG0470	DNA polymerase III
CFE88_RS08950	COG3870	Protein conserved in bacteria
CFE88_RS08955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFE88_RS08960	COG1982	Orn Lys Arg decarboxylase major
CFE88_RS08985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFE88_RS08990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFE88_RS08995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFE88_RS09020	COG0493	'glutamate synthase
CFE88_RS09025	COG0070	glutamate synthase
CFE88_RS09025	COG0067	glutamate synthase
CFE88_RS09025	COG0069	glutamate synthase activity
CFE88_RS09030	COG0583	DNA-binding transcription factor activity
CFE88_RS09055	COG0438	transferase activity, transferring glycosyl groups
CFE88_RS09060	COG3942	CHAP domain
CFE88_RS09060	COG1388	LysM domain
CFE88_RS09070	COG2011	ABC-type metal ion transport system permease component
CFE88_RS09075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFE88_RS09080	COG0626	cystathionine gamma-synthase activity
CFE88_RS09085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFE88_RS09095	COG0733	neurotransmitter:sodium symporter activity
CFE88_RS09105	COG1647	Serine aminopeptidase, S33
CFE88_RS09120	COG5609	conserved protein (DUF2294)
CFE88_RS09125	COG3002	Belongs to the UPF0753 family
CFE88_RS09130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFE88_RS09140	COG0523	cobalamin synthesis protein
CFE88_RS09195	COG3728	DNA packaging
CFE88_RS09195	COG5484	DNA packaging
CFE88_RS09295	COG0519	Catalyzes the synthesis of GMP from XMP
CFE88_RS09295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFE88_RS09300	COG0517	IMP dehydrogenase activity
CFE88_RS09300	COG0516	GMP reductase activity
CFE88_RS09305	COG2233	PERMEase
CFE88_RS09310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFE88_RS09325	COG5183	chlorophyll binding
CFE88_RS09335	COG1823	symporter activity
CFE88_RS09340	COG0778	Nitroreductase
CFE88_RS09350	COG0450	alkyl hydroperoxide reductase
CFE88_RS09355	COG3634	alkyl hydroperoxide reductase activity
CFE88_RS09390	COG1280	lysine exporter protein (LysE YggA)
CFE88_RS09430	COG1846	Transcriptional regulator
CFE88_RS09440	COG0693	protein deglycase activity
CFE88_RS09460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFE88_RS09470	COG0360	Binds together with S18 to 16S ribosomal RNA
CFE88_RS09485	COG0012	GTP binding
CFE88_RS09490	COG4481	Protein conserved in bacteria
CFE88_RS09495	COG0668	transmembrane transport
CFE88_RS09500	COG1475	DNA binding
CFE88_RS09510	COG0626	cystathionine gamma-synthase activity
CFE88_RS09515	COG0626	cystathionine gamma-synthase activity
CFE88_RS09520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CFE88_RS09520	COG0646	methionine synthase
CFE88_RS09525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFE88_RS09535	COG0183	Belongs to the thiolase family
CFE88_RS09550	COG1476	TRANSCRIPTIONal
CFE88_RS09560	COG4555	ABC transporter
CFE88_RS09580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFE88_RS09605	COG1136	(ABC) transporter
CFE88_RS09610	COG0577	efflux transmembrane transporter activity
CFE88_RS09625	COG0577	efflux transmembrane transporter activity
CFE88_RS09630	COG1136	(ABC) transporter
CFE88_RS09670	COG1475	DNA binding
CFE88_RS09675	COG0357	Ribosomal RNA small subunit methyltransferase G
CFE88_RS09680	COG0445	tRNA wobble uridine modification
CFE88_RS09685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFE88_RS09690	COG0594	ribonuclease P activity
CFE88_RS09700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFE88_RS09705	COG0592	DNA-directed DNA polymerase activity
CFE88_RS09710	COG2501	S4 domain
CFE88_RS09715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFE88_RS09720	COG0187	DNA topoisomerase II activity
CFE88_RS09725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFE88_RS09730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFE88_RS09735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFE88_RS09755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFE88_RS09765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CFE88_RS09770	COG0359	binds to the 23S rRNA
CFE88_RS09775	COG0305	Participates in initiation and elongation during chromosome replication
CFE88_RS09780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFE88_RS09800	COG0745	RESPONSE REGULATOR receiver
CFE88_RS09805	COG5002	protein histidine kinase activity
CFE88_RS09810	COG4863	YycH protein
CFE88_RS09820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFE88_RS09825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFE88_RS09835	COG1518	maintenance of DNA repeat elements
CFE88_RS09840	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CFE88_RS09935	COG0732	type I restriction modification DNA specificity domain
CFE88_RS09940	COG3949	Membrane
CFE88_RS09955	COG2217	Heavy metal translocating P-type atpase
CFE88_RS09960	COG1388	LysM domain
CFE88_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFE88_RS09970	COG2210	Belongs to the sulfur carrier protein TusA family
CFE88_RS09975	COG1937	Protein conserved in bacteria
CFE88_RS09980	COG0730	response to heat
CFE88_RS09985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFE88_RS09990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFE88_RS10010	COG0640	Transcriptional regulator
CFE88_RS10040	COG0668	transmembrane transport
CFE88_RS10085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFE88_RS10090	COG0579	oxidoreductase
CFE88_RS10095	COG1755	Isoprenylcysteine carboxyl methyltransferase
CFE88_RS10140	COG3391	amine dehydrogenase activity
CFE88_RS10145	COG0201	protein transport
CFE88_RS10155	COG1073	alpha beta
CFE88_RS10165	COG0653	protein targeting
CFE88_RS10170	COG0438	transferase activity, transferring glycosyl groups
CFE88_RS10185	COG1131	(ABC) transporter
CFE88_RS10195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFE88_RS10200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFE88_RS10205	COG0156	8-amino-7-oxononanoate synthase activity
CFE88_RS10210	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CFE88_RS10235	COG0523	cobalamin synthesis protein
CFE88_RS10250	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFE88_RS10260	COG1053	succinate dehydrogenase
CFE88_RS10260	COG0431	NADPH-dependent FMN reductase
CFE88_RS10260	COG3976	FMN-binding domain protein
CFE88_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS10325	COG0601	transmembrane transport
CFE88_RS10335	COG0444	Belongs to the ABC transporter superfamily
CFE88_RS10340	COG1124	(ABC) transporter
CFE88_RS10350	COG1882	Formate acetyltransferase
CFE88_RS10355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFE88_RS10360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFE88_RS10365	COG1114	Component of the transport system for branched-chain amino acids
CFE88_RS10370	COG1309	transcriptional regulator
CFE88_RS10375	COG3246	L-lysine catabolic process to acetate
CFE88_RS10380	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFE88_RS10415	COG1288	antiporter activity
CFE88_RS10420	COG0549	Belongs to the carbamate kinase family
CFE88_RS10425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFE88_RS10435	COG0346	lactoylglutathione lyase activity
CFE88_RS10440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CFE88_RS10445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFE88_RS10455	COG2376	Dihydroxyacetone kinase
CFE88_RS10460	COG1461	Dihydroxyacetone kinase
CFE88_RS10465	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CFE88_RS10480	COG2814	Major facilitator Superfamily
CFE88_RS10515	COG2814	Major facilitator Superfamily
CFE88_RS10530	COG2962	Rard protein
CFE88_RS10535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFE88_RS10540	COG0471	metal ion transport
CFE88_RS10545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFE88_RS10550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFE88_RS10555	COG0022	dehydrogenase e1 component
CFE88_RS10560	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFE88_RS10580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CFE88_RS10585	COG1054	Belongs to the UPF0176 family
CFE88_RS10590	COG3386	PFAM SMP-30 Gluconolaconase
CFE88_RS10595	COG2353	YceI-like domain
CFE88_RS10605	COG0579	oxidoreductase
CFE88_RS10630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFE88_RS10635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFE88_RS10640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFE88_RS10645	COG0131	Imidazoleglycerol-phosphate dehydratase
CFE88_RS10650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFE88_RS10655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFE88_RS10660	COG0107	imidazoleglycerol-phosphate synthase activity
CFE88_RS10665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFE88_RS10665	COG0140	phosphoribosyl-ATP diphosphatase activity
CFE88_RS10670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CFE88_RS10680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CFE88_RS10695	COG2814	Major facilitator Superfamily
CFE88_RS10700	COG0737	Belongs to the 5'-nucleotidase family
CFE88_RS10715	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFE88_RS10720	COG3639	organic phosphonate transmembrane transporter activity
CFE88_RS10735	COG1073	alpha beta
CFE88_RS10745	COG0653	protein targeting
CFE88_RS10750	COG0438	transferase activity, transferring glycosyl groups
CFE88_RS10775	COG2814	Major facilitator Superfamily
CFE88_RS10780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFE88_RS10795	COG1764	response to oxidative stress
CFE88_RS10805	COG3942	CHAP domain
CFE88_RS10805	COG1705	Flagellar rod assembly protein muramidase FlgJ
CFE88_RS10820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFE88_RS10820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFE88_RS10820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFE88_RS10855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFE88_RS10860	COG3227	Zinc metalloprotease (Elastase)
CFE88_RS10865	COG1438	arginine binding
CFE88_RS10870	COG2235	arginine
CFE88_RS10875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFE88_RS10885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFE88_RS10895	COG2843	Capsule synthesis protein
CFE88_RS10905	COG3961	Belongs to the TPP enzyme family
CFE88_RS10915	COG1388	LysM domain
CFE88_RS10915	COG3942	CHAP domain
CFE88_RS11045	COG4282	regulation of fungal-type cell wall biogenesis
CFE88_RS11100	COG4195	phage-related replication protein
CFE88_RS11110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFE88_RS11115	COG0702	epimerase
CFE88_RS11120	COG1785	Belongs to the alkaline phosphatase family
CFE88_RS11135	COG2205	protein histidine kinase activity
CFE88_RS11140	COG1136	(ABC) transporter
CFE88_RS11160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFE88_RS11190	COG1846	Transcriptional regulator
CFE88_RS11200	COG0386	Belongs to the glutathione peroxidase family
CFE88_RS11210	COG0175	sulfate reduction
CFE88_RS11215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CFE88_RS11220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFE88_RS11235	COG0730	response to heat
CFE88_RS11240	COG2046	Belongs to the sulfate adenylyltransferase family
CFE88_RS11245	COG0529	Catalyzes the synthesis of activated sulfate
CFE88_RS11255	COG1328	CTP reductase activity
CFE88_RS11260	COG0602	queuosine metabolic process
CFE88_RS11265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CFE88_RS11275	COG1510	regulation of RNA biosynthetic process
CFE88_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS11285	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CFE88_RS11300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFE88_RS11305	COG0574	Belongs to the PEP-utilizing enzyme family
CFE88_RS11305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFE88_RS11310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CFE88_RS11315	COG0579	oxidoreductase
CFE88_RS11325	COG3588	fructose-bisphosphate aldolase
CFE88_RS11330	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFE88_RS11360	COG0531	amino acid
CFE88_RS11365	COG0583	DNA-binding transcription factor activity
CFE88_RS11370	COG0039	L-malate dehydrogenase activity
CFE88_RS11375	COG0028	Belongs to the TPP enzyme family
CFE88_RS11380	COG3527	Alpha-acetolactate decarboxylase
CFE88_RS11390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFE88_RS11395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFE88_RS11400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFE88_RS11415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CFE88_RS11425	COG0167	dihydroorotate dehydrogenase activity
CFE88_RS11430	COG3001	Fructosamine kinase
CFE88_RS11435	COG1113	amino acid transport
CFE88_RS11455	COG0741	lytic transglycosylase activity
CFE88_RS11465	COG3942	CHAP domain
CFE88_RS11475	COG0436	Aminotransferase
CFE88_RS11485	COG2608	mercury ion transmembrane transporter activity
CFE88_RS11490	COG2217	Heavy metal translocating P-type atpase
CFE88_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS11505	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS11530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFE88_RS11535	COG3425	synthase
CFE88_RS11555	COG0583	DNA-binding transcription factor activity
CFE88_RS11560	COG1380	Effector of murein hydrolase LrgA
CFE88_RS11565	COG1346	cytolysis
CFE88_RS11570	COG0028	Belongs to the TPP enzyme family
CFE88_RS11575	COG2190	(PTS) system
CFE88_RS11575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFE88_RS11575	COG1263	PTS System
CFE88_RS11585	COG1266	CAAX protease self-immunity
CFE88_RS11590	COG1063	alcohol dehydrogenase
CFE88_RS11595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFE88_RS11600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CFE88_RS11615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFE88_RS11625	COG2843	Capsule synthesis protein
CFE88_RS11640	COG4975	Glucose uptake
CFE88_RS11645	COG1869	D-ribose catabolic process
CFE88_RS11655	COG1070	Carbohydrate kinase
CFE88_RS11670	COG1760	l-serine dehydratase
CFE88_RS11675	COG1760	l-serine dehydratase
CFE88_RS11690	COG3764	Sortase (surface protein transpeptidase)
CFE88_RS11700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFE88_RS11705	COG0778	Nitroreductase
CFE88_RS11715	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS11720	COG2514	catechol 2,3-dioxygenase activity
CFE88_RS11735	COG1012	belongs to the aldehyde dehydrogenase family
CFE88_RS11740	COG3949	Membrane
CFE88_RS11755	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CFE88_RS11760	COG0586	Pfam SNARE associated Golgi protein
CFE88_RS11765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CFE88_RS11770	COG2022	thiamine diphosphate biosynthetic process
CFE88_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFE88_RS11790	COG2271	Major facilitator Superfamily
CFE88_RS11805	COG4876	unkown
CFE88_RS11810	COG2357	RelA SpoT domain protein
CFE88_RS11835	COG0789	Transcriptional regulator
CFE88_RS11840	COG2271	Major facilitator Superfamily
CFE88_RS11845	COG1802	Transcriptional regulator
CFE88_RS11855	COG2610	gluconate transmembrane transporter activity
CFE88_RS11860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CFE88_RS11865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFE88_RS11870	COG1216	Glycosyl transferase, family 2
CFE88_RS11875	COG0438	transferase activity, transferring glycosyl groups
CFE88_RS11880	COG0494	nUDIX hydrolase
CFE88_RS11885	COG0556	nucleotide-excision repair
CFE88_RS11900	COG4221	oxidoreductase activity
CFE88_RS11905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFE88_RS11910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFE88_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
CFE88_RS11930	COG1363	Peptidase, m42
CFE88_RS11940	COG0069	glutamate synthase activity
CFE88_RS11955	COG4619	ABC transporter
CFE88_RS11960	COG0390	transport system, permease component
CFE88_RS11965	COG2814	Major facilitator Superfamily
CFE88_RS11970	COG2272	Belongs to the type-B carboxylesterase lipase family
CFE88_RS11975	COG0531	amino acid
CFE88_RS11980	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CFE88_RS12000	COG1063	alcohol dehydrogenase
CFE88_RS12020	COG1174	glycine betaine transport
CFE88_RS12025	COG1346	cytolysis
CFE88_RS12030	COG1380	Effector of murein hydrolase LrgA
CFE88_RS12035	COG3279	Response regulator of the LytR AlgR family
CFE88_RS12040	COG3275	phosphorelay sensor kinase activity
CFE88_RS12050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFE88_RS12055	COG0706	membrane insertase activity
CFE88_RS12065	COG0531	amino acid
CFE88_RS12070	COG1113	amino acid transport
CFE88_RS12095	COG1929	Belongs to the glycerate kinase type-1 family
CFE88_RS12110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CFE88_RS12115	COG0588	phosphoglycerate mutase activity
CFE88_RS12125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFE88_RS12130	COG0765	amino acid transport
CFE88_RS12135	COG1126	abc transporter atp-binding protein
CFE88_RS12140	COG2348	transferase activity, transferring amino-acyl groups
CFE88_RS12160	COG2116	formate transmembrane transporter activity
CFE88_RS12165	COG0454	-acetyltransferase
CFE88_RS12170	COG0747	negative chemotaxis
CFE88_RS12190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFE88_RS12195	COG2146	nitrite reductase [NAD(P)H] activity
CFE88_RS12205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CFE88_RS12210	COG1140	nitrate reductase beta subunit
CFE88_RS12225	COG2181	nitrate reductase activity
CFE88_RS12235	COG4585	Histidine kinase
CFE88_RS12240	COG2197	response regulator
CFE88_RS12245	COG2223	nitrite transmembrane transporter activity
CFE88_RS12250	COG1846	Transcriptional regulator
CFE88_RS12275	COG3871	stress protein (general stress protein 26)
CFE88_RS12290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFE88_RS12290	COG1263	PTS System
CFE88_RS12595	COG3682	Transcriptional regulator
CFE88_RS12630	COG1230	cation diffusion facilitator family transporter
CFE88_RS12640	COG1937	Protein conserved in bacteria
CFE88_RS12645	COG2217	Heavy metal translocating P-type atpase
CFE88_RS12685	COG0488	(ABC) transporter