locus-tag	class	description
J4Z28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J4Z28_RS00010	COG0592	DNA-directed DNA polymerase activity
J4Z28_RS00015	COG2501	S4 domain
J4Z28_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J4Z28_RS00025	COG0187	DNA topoisomerase II activity
J4Z28_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4Z28_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4Z28_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J4Z28_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4Z28_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
J4Z28_RS00075	COG0359	binds to the 23S rRNA
J4Z28_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
J4Z28_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J4Z28_RS00100	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS00105	COG5002	protein histidine kinase activity
J4Z28_RS00110	COG4863	YycH protein
J4Z28_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J4Z28_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J4Z28_RS00180	COG0549	Belongs to the carbamate kinase family
J4Z28_RS00185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4Z28_RS00190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4Z28_RS00200	COG2235	arginine
J4Z28_RS00225	COG0076	glutamate decarboxylase activity
J4Z28_RS00240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J4Z28_RS00250	COG1131	(ABC) transporter
J4Z28_RS00265	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS00270	COG5002	protein histidine kinase activity
J4Z28_RS00285	COG2217	Heavy metal translocating P-type atpase
J4Z28_RS00290	COG2132	Multicopper oxidase
J4Z28_RS00295	COG1388	LysM domain
J4Z28_RS00300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4Z28_RS00305	COG2210	Belongs to the sulfur carrier protein TusA family
J4Z28_RS00310	COG1937	Protein conserved in bacteria
J4Z28_RS00315	COG0730	response to heat
J4Z28_RS00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4Z28_RS00325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J4Z28_RS00345	COG0640	Transcriptional regulator
J4Z28_RS00360	COG0668	transmembrane transport
J4Z28_RS00365	COG0561	phosphatase activity
J4Z28_RS00395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4Z28_RS00400	COG0579	oxidoreductase
J4Z28_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS00415	COG1755	Isoprenylcysteine carboxyl methyltransferase
J4Z28_RS00425	COG4753	response regulator
J4Z28_RS00425	COG2207	Transcriptional regulator
J4Z28_RS00430	COG2972	Histidine kinase
J4Z28_RS00455	COG3583	domain protein
J4Z28_RS00455	COG4932	domain protein
J4Z28_RS00455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4Z28_RS00455	COG3583	domain protein
J4Z28_RS00455	COG4932	domain protein
J4Z28_RS00455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4Z28_RS00465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J4Z28_RS00470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J4Z28_RS00475	COG0156	8-amino-7-oxononanoate synthase activity
J4Z28_RS00480	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
J4Z28_RS00505	COG0523	cobalamin synthesis protein
J4Z28_RS00520	COG0803	Belongs to the bacterial solute-binding protein 9 family
J4Z28_RS00530	COG0431	NADPH-dependent FMN reductase
J4Z28_RS00530	COG1053	succinate dehydrogenase
J4Z28_RS00530	COG3976	FMN-binding domain protein
J4Z28_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS00575	COG0601	transmembrane transport
J4Z28_RS00585	COG0444	Belongs to the ABC transporter superfamily
J4Z28_RS00590	COG1124	(ABC) transporter
J4Z28_RS00600	COG1882	Formate acetyltransferase
J4Z28_RS00605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4Z28_RS00610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Z28_RS00615	COG1114	Component of the transport system for branched-chain amino acids
J4Z28_RS00620	COG1309	transcriptional regulator
J4Z28_RS00625	COG3246	L-lysine catabolic process to acetate
J4Z28_RS00630	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4Z28_RS00665	COG1288	antiporter activity
J4Z28_RS00670	COG0549	Belongs to the carbamate kinase family
J4Z28_RS00675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4Z28_RS00685	COG0346	lactoylglutathione lyase activity
J4Z28_RS00690	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J4Z28_RS00695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J4Z28_RS00705	COG2376	Dihydroxyacetone kinase
J4Z28_RS00710	COG1461	Dihydroxyacetone kinase
J4Z28_RS00715	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
J4Z28_RS00730	COG2814	Major facilitator Superfamily
J4Z28_RS00760	COG2814	Major facilitator Superfamily
J4Z28_RS00775	COG2962	Rard protein
J4Z28_RS00780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4Z28_RS00785	COG0471	metal ion transport
J4Z28_RS00790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4Z28_RS00795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4Z28_RS00800	COG0022	dehydrogenase e1 component
J4Z28_RS00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4Z28_RS00830	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
J4Z28_RS00835	COG1054	Belongs to the UPF0176 family
J4Z28_RS00840	COG3386	PFAM SMP-30 Gluconolaconase
J4Z28_RS00845	COG2353	YceI-like domain
J4Z28_RS00850	COG0579	oxidoreductase
J4Z28_RS00875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
J4Z28_RS00880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4Z28_RS00885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J4Z28_RS00890	COG0131	Imidazoleglycerol-phosphate dehydratase
J4Z28_RS00895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4Z28_RS00900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J4Z28_RS00905	COG0107	imidazoleglycerol-phosphate synthase activity
J4Z28_RS00910	COG0140	phosphoribosyl-ATP diphosphatase activity
J4Z28_RS00910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J4Z28_RS00915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
J4Z28_RS00920	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
J4Z28_RS00935	COG2814	Major facilitator Superfamily
J4Z28_RS00940	COG0737	Belongs to the 5'-nucleotidase family
J4Z28_RS00955	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
J4Z28_RS00960	COG3639	organic phosphonate transmembrane transporter activity
J4Z28_RS00980	COG0201	protein transport
J4Z28_RS00990	COG1073	alpha beta
J4Z28_RS01000	COG0653	protein targeting
J4Z28_RS01005	COG0438	transferase activity, transferring glycosyl groups
J4Z28_RS01030	COG2814	Major facilitator Superfamily
J4Z28_RS01035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4Z28_RS01050	COG1764	response to oxidative stress
J4Z28_RS01060	COG1705	Flagellar rod assembly protein muramidase FlgJ
J4Z28_RS01060	COG3942	CHAP domain
J4Z28_RS01070	COG1482	cell wall glycoprotein biosynthetic process
J4Z28_RS01075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Z28_RS01075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Z28_RS01075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Z28_RS01080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Z28_RS01080	COG3711	transcriptional antiterminator
J4Z28_RS01105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Z28_RS01110	COG3227	Zinc metalloprotease (Elastase)
J4Z28_RS01115	COG1438	arginine binding
J4Z28_RS01120	COG2235	arginine
J4Z28_RS01125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4Z28_RS01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4Z28_RS01145	COG2843	Capsule synthesis protein
J4Z28_RS01150	COG3961	Belongs to the TPP enzyme family
J4Z28_RS01180	COG4195	phage-related replication protein
J4Z28_RS01195	COG0702	epimerase
J4Z28_RS01200	COG1785	Belongs to the alkaline phosphatase family
J4Z28_RS01215	COG2205	protein histidine kinase activity
J4Z28_RS01220	COG1136	(ABC) transporter
J4Z28_RS01235	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4Z28_RS01260	COG1846	Transcriptional regulator
J4Z28_RS01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4Z28_RS01270	COG0386	Belongs to the glutathione peroxidase family
J4Z28_RS01275	COG0175	sulfate reduction
J4Z28_RS01280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4Z28_RS01285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4Z28_RS01300	COG0730	response to heat
J4Z28_RS01305	COG2046	Belongs to the sulfate adenylyltransferase family
J4Z28_RS01310	COG0529	Catalyzes the synthesis of activated sulfate
J4Z28_RS01320	COG1328	CTP reductase activity
J4Z28_RS01325	COG0602	queuosine metabolic process
J4Z28_RS01330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J4Z28_RS01340	COG1510	regulation of RNA biosynthetic process
J4Z28_RS01345	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS01350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J4Z28_RS01355	COG1473	amidohydrolase
J4Z28_RS01370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4Z28_RS01375	COG0574	Belongs to the PEP-utilizing enzyme family
J4Z28_RS01375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4Z28_RS01380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J4Z28_RS01385	COG0579	oxidoreductase
J4Z28_RS01395	COG3588	fructose-bisphosphate aldolase
J4Z28_RS01400	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4Z28_RS01430	COG0531	amino acid
J4Z28_RS01435	COG0583	DNA-binding transcription factor activity
J4Z28_RS01440	COG0039	L-malate dehydrogenase activity
J4Z28_RS01445	COG0028	Belongs to the TPP enzyme family
J4Z28_RS01450	COG3527	Alpha-acetolactate decarboxylase
J4Z28_RS01460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J4Z28_RS01465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J4Z28_RS01470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
J4Z28_RS01485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4Z28_RS01510	COG0167	dihydroorotate dehydrogenase activity
J4Z28_RS01515	COG3001	Fructosamine kinase
J4Z28_RS01520	COG1113	amino acid transport
J4Z28_RS01535	COG0741	lytic transglycosylase activity
J4Z28_RS01545	COG3942	CHAP domain
J4Z28_RS01550	COG0436	Aminotransferase
J4Z28_RS01560	COG2608	mercury ion transmembrane transporter activity
J4Z28_RS01565	COG2217	Heavy metal translocating P-type atpase
J4Z28_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS01605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4Z28_RS01610	COG3425	synthase
J4Z28_RS01630	COG0583	DNA-binding transcription factor activity
J4Z28_RS01635	COG1380	Effector of murein hydrolase LrgA
J4Z28_RS01640	COG1346	cytolysis
J4Z28_RS01645	COG0028	Belongs to the TPP enzyme family
J4Z28_RS01650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4Z28_RS01650	COG2190	(PTS) system
J4Z28_RS01650	COG1263	PTS System
J4Z28_RS01660	COG1063	alcohol dehydrogenase
J4Z28_RS01670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4Z28_RS01685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J4Z28_RS01695	COG2843	Capsule synthesis protein
J4Z28_RS01710	COG4975	Glucose uptake
J4Z28_RS01715	COG1869	D-ribose catabolic process
J4Z28_RS01725	COG1070	Carbohydrate kinase
J4Z28_RS01740	COG1760	l-serine dehydratase
J4Z28_RS01745	COG1760	l-serine dehydratase
J4Z28_RS01765	COG3764	Sortase (surface protein transpeptidase)
J4Z28_RS01775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4Z28_RS01780	COG0778	Nitroreductase
J4Z28_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS01795	COG2514	catechol 2,3-dioxygenase activity
J4Z28_RS01810	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS01815	COG3949	Membrane
J4Z28_RS01825	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
J4Z28_RS01830	COG0586	Pfam SNARE associated Golgi protein
J4Z28_RS01835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4Z28_RS01840	COG2022	thiamine diphosphate biosynthetic process
J4Z28_RS01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4Z28_RS01860	COG2271	Major facilitator Superfamily
J4Z28_RS01875	COG4876	unkown
J4Z28_RS01880	COG2357	RelA SpoT domain protein
J4Z28_RS01895	COG0789	Transcriptional regulator
J4Z28_RS01900	COG2271	Major facilitator Superfamily
J4Z28_RS01905	COG1802	Transcriptional regulator
J4Z28_RS01915	COG2610	gluconate transmembrane transporter activity
J4Z28_RS01920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4Z28_RS01925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4Z28_RS01930	COG0438	transferase activity, transferring glycosyl groups
J4Z28_RS01935	COG0494	nUDIX hydrolase
J4Z28_RS01955	COG4221	oxidoreductase activity
J4Z28_RS01960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Z28_RS01965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J4Z28_RS01975	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS01985	COG1363	Peptidase, m42
J4Z28_RS01995	COG0069	glutamate synthase activity
J4Z28_RS02010	COG4619	ABC transporter
J4Z28_RS02015	COG0390	transport system, permease component
J4Z28_RS02020	COG2814	Major facilitator Superfamily
J4Z28_RS02025	COG2272	Belongs to the type-B carboxylesterase lipase family
J4Z28_RS02030	COG0531	amino acid
J4Z28_RS02040	COG1063	alcohol dehydrogenase
J4Z28_RS02060	COG1174	glycine betaine transport
J4Z28_RS02065	COG1346	cytolysis
J4Z28_RS02070	COG1380	Effector of murein hydrolase LrgA
J4Z28_RS02075	COG3279	Response regulator of the LytR AlgR family
J4Z28_RS02080	COG3275	phosphorelay sensor kinase activity
J4Z28_RS02090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4Z28_RS02095	COG0706	membrane insertase activity
J4Z28_RS02105	COG0531	amino acid
J4Z28_RS02110	COG1113	amino acid transport
J4Z28_RS02135	COG1929	Belongs to the glycerate kinase type-1 family
J4Z28_RS02150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4Z28_RS02155	COG0588	phosphoglycerate mutase activity
J4Z28_RS02165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4Z28_RS02170	COG0765	amino acid transport
J4Z28_RS02175	COG1126	abc transporter atp-binding protein
J4Z28_RS02185	COG2348	transferase activity, transferring amino-acyl groups
J4Z28_RS02205	COG2116	formate transmembrane transporter activity
J4Z28_RS02210	COG0454	-acetyltransferase
J4Z28_RS02220	COG0747	negative chemotaxis
J4Z28_RS02230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4Z28_RS02235	COG2146	nitrite reductase [NAD(P)H] activity
J4Z28_RS02245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
J4Z28_RS02250	COG1140	nitrate reductase beta subunit
J4Z28_RS02260	COG2181	nitrate reductase activity
J4Z28_RS02275	COG2197	response regulator
J4Z28_RS02280	COG2223	nitrite transmembrane transporter activity
J4Z28_RS02285	COG1846	Transcriptional regulator
J4Z28_RS02290	COG0778	Nitroreductase
J4Z28_RS02310	COG3871	stress protein (general stress protein 26)
J4Z28_RS02325	COG1263	PTS System
J4Z28_RS02325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4Z28_RS02365	COG0604	alcohol dehydrogenase
J4Z28_RS02370	COG0456	acetyltransferase
J4Z28_RS02375	COG0463	Glycosyl transferase, family 2
J4Z28_RS02375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4Z28_RS02385	COG0463	Glycosyl transferase, family 2
J4Z28_RS02385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4Z28_RS02390	COG1620	l-lactate permease
J4Z28_RS02395	COG0438	transferase activity, transferring glycosyl groups
J4Z28_RS02400	COG0579	oxidoreductase
J4Z28_RS02405	COG3850	Histidine kinase
J4Z28_RS02405	COG5002	protein histidine kinase activity
J4Z28_RS02410	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS02415	COG0577	efflux transmembrane transporter activity
J4Z28_RS02420	COG1136	(ABC) transporter
J4Z28_RS02435	COG4640	response to antibiotic
J4Z28_RS02440	COG2814	Major facilitator Superfamily
J4Z28_RS02450	COG1566	PFAM secretion protein HlyD family protein
J4Z28_RS02455	COG2814	Major facilitator Superfamily
J4Z28_RS02465	COG0657	acetylesterase activity
J4Z28_RS02480	COG0598	Magnesium transport protein CorA
J4Z28_RS02485	COG1304	FMN binding
J4Z28_RS02490	COG0786	glutamate:sodium symporter activity
J4Z28_RS02510	COG2094	Belongs to the DNA glycosylase MPG family
J4Z28_RS02525	COG1069	ribulokinase activity
J4Z28_RS02530	COG2017	converts alpha-aldose to the beta-anomer
J4Z28_RS02535	COG2258	MOSC domain
J4Z28_RS02540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J4Z28_RS02550	COG1266	CAAX protease self-immunity
J4Z28_RS02555	COG0010	Belongs to the arginase family
J4Z28_RS02560	COG1473	amidohydrolase
J4Z28_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS02570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4Z28_RS02595	COG1737	Transcriptional regulator
J4Z28_RS02600	COG1263	PTS System
J4Z28_RS02600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4Z28_RS02610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4Z28_RS02630	COG1113	amino acid transport
J4Z28_RS02640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4Z28_RS02640	COG1263	PTS System
J4Z28_RS02645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J4Z28_RS02660	COG1266	CAAX protease self-immunity
J4Z28_RS02665	COG2378	regulation of single-species biofilm formation
J4Z28_RS02670	COG0483	inositol monophosphate 1-phosphatase activity
J4Z28_RS02675	COG1316	TRANSCRIPTIONal
J4Z28_RS02695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4Z28_RS02700	COG2076	Multidrug Resistance protein
J4Z28_RS02705	COG2076	Multidrug Resistance protein
J4Z28_RS02710	COG3942	CHAP domain
J4Z28_RS02725	COG1757	Na H antiporter
J4Z28_RS02730	COG3942	CHAP domain
J4Z28_RS02755	COG0829	nickel cation binding
J4Z28_RS02760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J4Z28_RS02765	COG0830	nickel cation binding
J4Z28_RS02770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J4Z28_RS02775	COG0804	urea catabolic process
J4Z28_RS02780	COG0832	Belongs to the urease beta subunit family
J4Z28_RS02785	COG0831	urea catabolic process
J4Z28_RS02795	COG1960	acyl-CoA dehydrogenase activity
J4Z28_RS02800	COG1957	nucleoside hydrolase
J4Z28_RS02805	COG1268	BioY protein
J4Z28_RS02820	COG0725	ABC transporter, periplasmic molybdate-binding protein
J4Z28_RS02825	COG4149	molybdate abc transporter
J4Z28_RS02830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J4Z28_RS02835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4Z28_RS02840	COG0521	Mo-molybdopterin cofactor biosynthetic process
J4Z28_RS02845	COG0315	cyclic pyranopterin monophosphate synthase activity
J4Z28_RS02850	COG0303	'Molybdopterin
J4Z28_RS02860	COG0314	molybdopterin synthase activity
J4Z28_RS02870	COG0746	molybdenum cofactor guanylyltransferase activity
J4Z28_RS02875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J4Z28_RS02900	COG2814	Major facilitator Superfamily
J4Z28_RS02920	COG2348	transferase activity, transferring amino-acyl groups
J4Z28_RS02925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4Z28_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS02950	COG4975	Glucose uptake
J4Z28_RS02955	COG0551	DNA topoisomerase type I activity
J4Z28_RS02955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4Z28_RS02960	COG2252	PERMEase
J4Z28_RS02975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J4Z28_RS02980	COG0088	Forms part of the polypeptide exit tunnel
J4Z28_RS02985	COG0089	rRNA binding
J4Z28_RS02990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J4Z28_RS02995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J4Z28_RS03000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J4Z28_RS03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J4Z28_RS03010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J4Z28_RS03020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4Z28_RS03025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4Z28_RS03030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J4Z28_RS03035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J4Z28_RS03040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4Z28_RS03045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J4Z28_RS03050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J4Z28_RS03055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J4Z28_RS03060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J4Z28_RS03065	COG1841	ribosomal large subunit assembly
J4Z28_RS03070	COG0200	Binds to the 23S rRNA
J4Z28_RS03075	COG0201	protein transport
J4Z28_RS03080	COG0563	adenylate kinase activity
J4Z28_RS03085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J4Z28_RS03090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4Z28_RS03095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4Z28_RS03100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J4Z28_RS03105	COG0202	RNA polymerase activity
J4Z28_RS03110	COG0203	ribosomal protein L17
J4Z28_RS03115	COG1122	ATPase activity
J4Z28_RS03120	COG1122	ATPase activity
J4Z28_RS03130	COG0101	tRNA pseudouridine synthase activity
J4Z28_RS03135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J4Z28_RS03140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4Z28_RS03145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4Z28_RS03150	COG1349	DNA-binding transcription factor activity
J4Z28_RS03155	COG0698	ribose 5-phosphate isomerase
J4Z28_RS03160	COG0698	ribose 5-phosphate isomerase
J4Z28_RS03165	COG1105	Belongs to the carbohydrate kinase PfkB family
J4Z28_RS03170	COG3684	Belongs to the aldolase LacD family
J4Z28_RS03175	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4Z28_RS03180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4Z28_RS03180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4Z28_RS03185	COG2723	6-phospho-beta-galactosidase activity
J4Z28_RS03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4Z28_RS03200	COG2130	NADP-dependent
J4Z28_RS03205	COG0604	alcohol dehydrogenase
J4Z28_RS03220	COG1302	Protein conserved in bacteria
J4Z28_RS03225	COG4264	IucA IucC family
J4Z28_RS03230	COG2814	Major facilitator Superfamily
J4Z28_RS03235	COG4264	IucA IucC family
J4Z28_RS03240	COG3457	Alanine racemase
J4Z28_RS03245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J4Z28_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4Z28_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4Z28_RS03260	COG3314	Sporulation integral membrane protein YlbJ
J4Z28_RS03265	COG2329	Antibiotic biosynthesis monooxygenase
J4Z28_RS03275	COG1988	membrane-bound metal-dependent
J4Z28_RS03280	COG4284	Utp--glucose-1-phosphate uridylyltransferase
J4Z28_RS03300	COG2814	Major facilitator Superfamily
J4Z28_RS03305	COG0489	protein tyrosine kinase activity
J4Z28_RS03355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J4Z28_RS03365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4Z28_RS03375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4Z28_RS03380	COG0561	phosphatase activity
J4Z28_RS03400	COG0640	Transcriptional regulator
J4Z28_RS03405	COG0702	epimerase
J4Z28_RS03410	COG1482	cell wall glycoprotein biosynthetic process
J4Z28_RS03430	COG0783	Belongs to the Dps family
J4Z28_RS03435	COG0813	purine-nucleoside phosphorylase activity
J4Z28_RS03440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J4Z28_RS03445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
J4Z28_RS03450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J4Z28_RS03460	COG1854	S-ribosylhomocysteine lyase activity
J4Z28_RS03480	COG5146	pantothenate kinase activity
J4Z28_RS03490	COG3343	RNA polymerase activity
J4Z28_RS03495	COG0504	CTP synthase activity
J4Z28_RS03505	COG0191	fructose-bisphosphate aldolase activity
J4Z28_RS03510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4Z28_RS03515	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS03520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J4Z28_RS03525	COG0254	rRNA binding
J4Z28_RS03530	COG1435	thymidine kinase activity
J4Z28_RS03535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4Z28_RS03540	COG2890	protein-(glutamine-N5) methyltransferase activity
J4Z28_RS03545	COG0009	L-threonylcarbamoyladenylate synthase
J4Z28_RS03550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4Z28_RS03555	COG4475	Protein of unknown function (DUF436)
J4Z28_RS03560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J4Z28_RS03565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J4Z28_RS03570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J4Z28_RS03580	COG0356	it plays a direct role in the translocation of protons across the membrane
J4Z28_RS03590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4Z28_RS03595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4Z28_RS03600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4Z28_RS03605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4Z28_RS03610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4Z28_RS03615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4Z28_RS03625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4Z28_RS03630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4Z28_RS03640	COG0629	single-stranded DNA binding
J4Z28_RS03645	COG1388	LysM domain
J4Z28_RS03650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J4Z28_RS03660	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J4Z28_RS03665	COG0352	thiamine-phosphate diphosphorylase activity
J4Z28_RS03670	COG0706	membrane insertase activity
J4Z28_RS03675	COG1418	mRNA catabolic process
J4Z28_RS03680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4Z28_RS03685	COG1937	Protein conserved in bacteria
J4Z28_RS03700	COG0772	Belongs to the SEDS family
J4Z28_RS03705	COG1181	Belongs to the D-alanine--D-alanine ligase family
J4Z28_RS03710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4Z28_RS03715	COG0513	Belongs to the DEAD box helicase family
J4Z28_RS03725	COG3428	Bacterial PH domain
J4Z28_RS03730	COG3402	PFAM membrane-flanked domain
J4Z28_RS03735	COG0736	holo-[acyl-carrier-protein] synthase activity
J4Z28_RS03740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4Z28_RS03750	COG2337	Toxic component of a toxin-antitoxin (TA) module
J4Z28_RS03755	COG2208	phosphoserine phosphatase activity
J4Z28_RS03770	COG1191	sigma factor activity
J4Z28_RS03775	COG2183	response to ionizing radiation
J4Z28_RS03780	COG3091	SprT-like family
J4Z28_RS03810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4Z28_RS03815	COG0066	3-isopropylmalate dehydratase activity
J4Z28_RS03820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J4Z28_RS03825	COG0473	3-isopropylmalate dehydrogenase activity
J4Z28_RS03830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4Z28_RS03835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J4Z28_RS03845	COG0028	Belongs to the TPP enzyme family
J4Z28_RS03850	COG0129	dihydroxy-acid dehydratase activity
J4Z28_RS03855	COG0802	atpase or kinase
J4Z28_RS03860	COG1214	PFAM Peptidase M22, glycoprotease
J4Z28_RS03865	COG0456	acetyltransferase
J4Z28_RS03870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J4Z28_RS03875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4Z28_RS03880	COG0488	(ABC) transporter
J4Z28_RS03885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J4Z28_RS03895	COG2391	methyltransferase activity
J4Z28_RS03900	COG0425	Belongs to the sulfur carrier protein TusA family
J4Z28_RS03905	COG0004	ammonium transporteR
J4Z28_RS03910	COG1609	Transcriptional regulator
J4Z28_RS03915	COG1621	beta-fructofuranosidase activity
J4Z28_RS03920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4Z28_RS03925	COG3279	Response regulator of the LytR AlgR family
J4Z28_RS03930	COG3290	protein histidine kinase activity
J4Z28_RS03970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J4Z28_RS03975	COG0459	protein refolding
J4Z28_RS03980	COG0582	viral genome integration into host DNA
J4Z28_RS04130	COG1725	Transcriptional regulator
J4Z28_RS04135	COG1131	(ABC) transporter
J4Z28_RS04145	COG1131	(ABC) transporter
J4Z28_RS04190	COG2706	6-phosphogluconolactonase activity
J4Z28_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS04200	COG1227	inorganic diphosphatase activity
J4Z28_RS04205	COG1335	isochorismatase
J4Z28_RS04215	COG0077	Prephenate dehydratase
J4Z28_RS04225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J4Z28_RS04230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J4Z28_RS04235	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
J4Z28_RS04245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4Z28_RS04250	COG4496	protein, YerC YecD
J4Z28_RS04255	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
J4Z28_RS04260	COG0210	DNA helicase
J4Z28_RS04265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4Z28_RS04270	COG4851	CamS sex pheromone cAM373 precursor
J4Z28_RS04275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4Z28_RS04280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4Z28_RS04285	COG0154	amidase activity
J4Z28_RS04290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4Z28_RS04295	COG1597	lipid kinase activity
J4Z28_RS04300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4Z28_RS04310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4Z28_RS04320	COG1528	Iron-storage protein
J4Z28_RS04340	COG4129	membrane
J4Z28_RS04345	COG0024	Methionine aminopeptidase
J4Z28_RS04360	COG4585	Histidine kinase
J4Z28_RS04365	COG2197	response regulator
J4Z28_RS04370	COG1295	ribonuclease BN
J4Z28_RS04380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4Z28_RS04385	COG4840	Belongs to the UPF0435 family
J4Z28_RS04390	COG2309	aminopeptidase activity
J4Z28_RS04395	COG1607	acyl-coa hydrolase
J4Z28_RS04400	COG0535	radical SAM domain protein
J4Z28_RS04410	COG0693	protein deglycase activity
J4Z28_RS04415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4Z28_RS04420	COG2137	regulation of response to DNA damage stimulus
J4Z28_RS04430	COG1134	teichoic acid transport
J4Z28_RS04430	COG1388	LysM domain
J4Z28_RS04440	COG1988	membrane-bound metal-dependent
J4Z28_RS04450	COG3557	Belongs to the UPF0374 family
J4Z28_RS04460	COG4129	membrane
J4Z28_RS04465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J4Z28_RS04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J4Z28_RS04475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4Z28_RS04480	COG0735	belongs to the Fur family
J4Z28_RS04650	COG0765	amino acid transport
J4Z28_RS04655	COG1126	abc transporter atp-binding protein
J4Z28_RS04665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4Z28_RS04675	COG0363	glucosamine-6-phosphate deaminase activity
J4Z28_RS04690	COG0114	fumarate hydratase activity
J4Z28_RS04695	COG0564	pseudouridine synthase activity
J4Z28_RS04700	COG2203	Gaf domain
J4Z28_RS04700	COG4585	Histidine kinase
J4Z28_RS04705	COG2197	response regulator
J4Z28_RS04715	COG4399	Belongs to the UPF0754 family
J4Z28_RS04720	COG3679	Belongs to the UPF0342 family
J4Z28_RS04725	COG0420	3'-5' exonuclease activity
J4Z28_RS04735	COG3481	metal-dependent phosphohydrolase, HD sub domain
J4Z28_RS04745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4Z28_RS04760	COG0537	adenosine 5'-monophosphoramidase activity
J4Z28_RS04765	COG1131	(ABC) transporter
J4Z28_RS04770	COG4473	ABC transporter
J4Z28_RS04780	COG2329	Antibiotic biosynthesis monooxygenase
J4Z28_RS04785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J4Z28_RS04790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J4Z28_RS04795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J4Z28_RS04870	COG0318	PFAM AMP-dependent synthetase and ligase
J4Z28_RS04880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J4Z28_RS04885	COG0494	nUDIX hydrolase
J4Z28_RS04890	COG1506	peptidase
J4Z28_RS04895	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J4Z28_RS04900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J4Z28_RS04925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4Z28_RS04930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4Z28_RS04940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4Z28_RS04965	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4Z28_RS04965	COG4193	domain, Protein
J4Z28_RS04965	COG3266	domain, Protein
J4Z28_RS04975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4Z28_RS04975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4Z28_RS04985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4Z28_RS04985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J4Z28_RS04990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J4Z28_RS04995	COG0506	proline dehydrogenase activity
J4Z28_RS05000	COG2267	carboxylic ester hydrolase activity
J4Z28_RS05010	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J4Z28_RS05015	COG1242	4 iron, 4 sulfur cluster binding
J4Z28_RS05020	COG2814	Major facilitator Superfamily
J4Z28_RS05025	COG0495	leucyl-tRNA aminoacylation
J4Z28_RS05040	COG2081	HI0933 family
J4Z28_RS05045	COG2244	polysaccharide biosynthetic process
J4Z28_RS05050	COG1187	pseudouridine synthase activity
J4Z28_RS05060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4Z28_RS05065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4Z28_RS05070	COG0510	thiamine kinase activity
J4Z28_RS05075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4Z28_RS05085	COG1363	Peptidase, m42
J4Z28_RS05090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4Z28_RS05095	COG4848	Belongs to the UPF0354 family
J4Z28_RS05100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Z28_RS05105	COG1674	ftsk spoiiie
J4Z28_RS05110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4Z28_RS05115	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
J4Z28_RS05125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J4Z28_RS05125	COG1605	Chorismate mutase
J4Z28_RS05130	COG1609	Transcriptional regulator
J4Z28_RS05135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J4Z28_RS05145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J4Z28_RS05150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4Z28_RS05155	COG0204	Acyl-transferase
J4Z28_RS05160	COG1263	PTS System
J4Z28_RS05160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4Z28_RS05170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4Z28_RS05175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4Z28_RS05180	COG1764	response to oxidative stress
J4Z28_RS05185	COG0584	glycerophosphoryl diester phosphodiesterase
J4Z28_RS05190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4Z28_RS05195	COG1956	GAF domain-containing protein
J4Z28_RS05200	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
J4Z28_RS05210	COG0301	tRNA thio-modification
J4Z28_RS05220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
J4Z28_RS05225	COG0827	DNA restriction-modification system
J4Z28_RS05230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4Z28_RS05235	COG0589	response to stress
J4Z28_RS05240	COG0686	Belongs to the AlaDH PNT family
J4Z28_RS05245	COG0006	proline dipeptidase activity
J4Z28_RS05250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J4Z28_RS05260	COG4109	DRTGG domain
J4Z28_RS05265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J4Z28_RS05270	COG0587	DNA-directed DNA polymerase activity
J4Z28_RS05275	COG0281	malic enzyme
J4Z28_RS05280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J4Z28_RS05285	COG0825	malonyl-CoA metabolic process
J4Z28_RS05290	COG0205	6-phosphofructokinase activity
J4Z28_RS05295	COG0469	pyruvate kinase activity
J4Z28_RS05300	COG1113	amino acid transport
J4Z28_RS05305	COG0372	Belongs to the citrate synthase family
J4Z28_RS05310	COG0538	isocitrate dehydrogenase activity
J4Z28_RS05315	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS05320	COG5002	protein histidine kinase activity
J4Z28_RS05325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4Z28_RS05325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4Z28_RS05330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J4Z28_RS05335	COG0237	dephospho-CoA kinase activity
J4Z28_RS05345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4Z28_RS05350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4Z28_RS05355	COG3611	Membrane attachment protein
J4Z28_RS05360	COG1484	DNA-dependent DNA replication
J4Z28_RS05365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J4Z28_RS05370	COG0833	amino acid
J4Z28_RS05375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J4Z28_RS05380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J4Z28_RS05385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J4Z28_RS05390	COG4112	unkown
J4Z28_RS05400	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4Z28_RS05405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J4Z28_RS05410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4Z28_RS05415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J4Z28_RS05425	COG0181	hydroxymethylbilane synthase activity
J4Z28_RS05435	COG0113	porphobilinogen synthase activity
J4Z28_RS05440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J4Z28_RS05450	COG2818	Glycosylase
J4Z28_RS05455	COG0525	valine-tRNA ligase activity
J4Z28_RS05460	COG0285	dihydrofolate synthase activity
J4Z28_RS05470	COG2003	Belongs to the UPF0758 family
J4Z28_RS05500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J4Z28_RS05505	COG2868	ribosomal protein
J4Z28_RS05510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4Z28_RS05515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4Z28_RS05520	COG4492	Belongs to the UPF0735 family
J4Z28_RS05525	COG0632	four-way junction helicase activity
J4Z28_RS05530	COG2255	four-way junction helicase activity
J4Z28_RS05535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J4Z28_RS05540	COG0343	queuine tRNA-ribosyltransferase activity
J4Z28_RS05545	COG1862	Preprotein translocase
J4Z28_RS05550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4Z28_RS05550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4Z28_RS05555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J4Z28_RS05555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4Z28_RS05560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4Z28_RS05565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4Z28_RS05570	COG1490	D-aminoacyl-tRNA deacylase activity
J4Z28_RS05575	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4Z28_RS05580	COG0124	histidyl-tRNA synthetase
J4Z28_RS05585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J4Z28_RS05595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4Z28_RS05600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4Z28_RS05605	COG1959	2 iron, 2 sulfur cluster binding
J4Z28_RS05615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4Z28_RS05620	COG1104	cysteine desulfurase activity
J4Z28_RS05625	COG0482	sulfurtransferase activity
J4Z28_RS05635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4Z28_RS05640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4Z28_RS05645	COG4472	Bacterial protein of unknown function (DUF965)
J4Z28_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4Z28_RS05655	COG3906	Belongs to the UPF0473 family
J4Z28_RS05665	COG0826	peptidase U32
J4Z28_RS05670	COG0826	peptidase U32
J4Z28_RS05675	COG0572	uridine kinase
J4Z28_RS05680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4Z28_RS05690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J4Z28_RS05695	COG1984	allophanate hydrolase subunit 2
J4Z28_RS05700	COG0511	ligase activity, forming carbon-carbon bonds
J4Z28_RS05705	COG0439	Biotin carboxylase
J4Z28_RS05710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J4Z28_RS05715	COG1914	H( )-stimulated, divalent metal cation uptake system
J4Z28_RS05720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J4Z28_RS05725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J4Z28_RS05730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4Z28_RS05735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4Z28_RS05740	COG1534	Rna-binding protein
J4Z28_RS05745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J4Z28_RS05750	COG1713	HD superfamily hydrolase involved in NAD metabolism
J4Z28_RS05755	COG0799	negative regulation of ribosome biogenesis
J4Z28_RS05760	COG2226	methyltransferase
J4Z28_RS05770	COG2131	deaminase
J4Z28_RS05775	COG2333	competence protein COMEC
J4Z28_RS05775	COG0658	competence protein
J4Z28_RS05780	COG1466	dna polymerase III delta subunit
J4Z28_RS05785	COG0268	Binds directly to 16S ribosomal RNA
J4Z28_RS05790	COG0481	GTPase activity
J4Z28_RS05795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4Z28_RS05800	COG1420	regulation of RNA biosynthetic process
J4Z28_RS05805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4Z28_RS05810	COG0443	Heat shock 70 kDa protein
J4Z28_RS05815	COG0484	heat shock protein binding
J4Z28_RS05820	COG2264	protein methyltransferase activity
J4Z28_RS05825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4Z28_RS05830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4Z28_RS05840	COG1030	water channel activity
J4Z28_RS05845	COG4864	UPF0365 protein
J4Z28_RS05855	COG1702	phosphate starvation-inducible protein PhoH
J4Z28_RS05860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J4Z28_RS05865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4Z28_RS05870	COG0295	cytidine deaminase activity
J4Z28_RS05875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J4Z28_RS05880	COG1381	Involved in DNA repair and RecF pathway recombination
J4Z28_RS05885	COG0423	glycine-tRNA ligase activity
J4Z28_RS05890	COG0517	IMP dehydrogenase activity
J4Z28_RS05895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J4Z28_RS05900	COG0358	DNA primase activity
J4Z28_RS05905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4Z28_RS05910	COG2384	SAM-dependent methyltransferase
J4Z28_RS05915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4Z28_RS05920	COG0513	Belongs to the DEAD box helicase family
J4Z28_RS05925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J4Z28_RS05930	COG1121	(ABC) transporter
J4Z28_RS05935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4Z28_RS05940	COG0735	belongs to the Fur family
J4Z28_RS05945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4Z28_RS05950	COG0768	penicillin binding
J4Z28_RS05955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4Z28_RS05960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4Z28_RS05970	COG4483	Protein conserved in bacteria
J4Z28_RS05975	COG1940	carbohydrate kinase activity
J4Z28_RS05980	COG0011	TIGRFAM Protein of
J4Z28_RS05990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4Z28_RS05995	COG1459	type II secretion system
J4Z28_RS06000	COG4537	Required for transformation and DNA binding
J4Z28_RS06020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4Z28_RS06025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J4Z28_RS06030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4Z28_RS06035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J4Z28_RS06045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4Z28_RS06050	COG0095	Lipoate-protein ligase
J4Z28_RS06065	COG0006	proline dipeptidase activity
J4Z28_RS06070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4Z28_RS06075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J4Z28_RS06080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J4Z28_RS06085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4Z28_RS06090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4Z28_RS06095	COG0511	ligase activity, forming carbon-carbon bonds
J4Z28_RS06100	COG0439	Biotin carboxylase
J4Z28_RS06105	COG1302	Protein conserved in bacteria
J4Z28_RS06110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4Z28_RS06115	COG1570	exodeoxyribonuclease VII activity
J4Z28_RS06120	COG1722	exodeoxyribonuclease VII activity
J4Z28_RS06130	COG1438	arginine binding
J4Z28_RS06135	COG0497	DNA recombination
J4Z28_RS06140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4Z28_RS06145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4Z28_RS06150	COG0022	dehydrogenase e1 component
J4Z28_RS06155	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4Z28_RS06165	COG4129	membrane
J4Z28_RS06175	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4Z28_RS06180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J4Z28_RS06185	COG0366	Alpha amylase catalytic
J4Z28_RS06195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J4Z28_RS06200	COG1234	tRNA 3'-trailer cleavage
J4Z28_RS06205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4Z28_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS06215	COG0667	Aldo Keto reductase
J4Z28_RS06220	COG0494	nUDIX hydrolase
J4Z28_RS06225	COG0735	belongs to the Fur family
J4Z28_RS06230	COG4974	Belongs to the 'phage' integrase family
J4Z28_RS06235	COG1547	Domain of unknown function (DUF309)
J4Z28_RS06240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J4Z28_RS06245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J4Z28_RS06250	COG1187	pseudouridine synthase activity
J4Z28_RS06255	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS06270	COG1141	Ferredoxin
J4Z28_RS06280	COG0514	ATP-dependent DNA helicase (RecQ)
J4Z28_RS06285	COG1388	LysM domain
J4Z28_RS06290	COG0492	ferredoxin-NADP+ reductase activity
J4Z28_RS06295	COG0252	asparaginase activity
J4Z28_RS06300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J4Z28_RS06305	COG0539	negative regulation of cytoplasmic translation
J4Z28_RS06310	COG1160	GTP binding
J4Z28_RS06315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4Z28_RS06330	COG2226	methyltransferase
J4Z28_RS06340	COG0105	UTP biosynthetic process
J4Z28_RS06345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4Z28_RS06350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4Z28_RS06355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4Z28_RS06365	COG5582	Belongs to the UPF0302 family
J4Z28_RS06370	COG4347	Protein of unknown function (DUF1405)
J4Z28_RS06375	COG2738	Putative neutral zinc metallopeptidase
J4Z28_RS06380	COG1694	Mazg nucleotide pyrophosphohydrolase
J4Z28_RS06385	COG0438	transferase activity, transferring glycosyl groups
J4Z28_RS06390	COG0617	tRNA 3'-terminal CCA addition
J4Z28_RS06395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J4Z28_RS06395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J4Z28_RS06400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4Z28_RS06400	COG1199	ATP-dependent helicase activity
J4Z28_RS06405	COG0017	Asparaginyl-tRNA synthetase
J4Z28_RS06410	COG3935	DnaD domain protein
J4Z28_RS06415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4Z28_RS06425	COG4499	WXG100 protein secretion system (Wss), protein YukC
J4Z28_RS06425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4Z28_RS06430	COG3331	DNA recombination
J4Z28_RS06440	COG4474	Belongs to the UPF0398 family
J4Z28_RS06445	COG3599	regulation of cell shape
J4Z28_RS06455	COG0116	Belongs to the methyltransferase superfamily
J4Z28_RS06465	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
J4Z28_RS06470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4Z28_RS06475	COG1196	nuclear chromosome segregation
J4Z28_RS06475	COG4372	Transposase
J4Z28_RS06475	COG1511	domain protein
J4Z28_RS06485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J4Z28_RS06495	COG1413	lyase activity
J4Z28_RS06510	COG1136	(ABC) transporter
J4Z28_RS06535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4Z28_RS06540	COG2190	(PTS) system
J4Z28_RS06545	COG4479	Belongs to the UPF0346 family
J4Z28_RS06550	COG0793	Belongs to the peptidase S41A family
J4Z28_RS06560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4Z28_RS06565	COG0671	phosphoesterase, PA-phosphatase related
J4Z28_RS06570	COG3842	ATPase activity
J4Z28_RS06575	COG4209	transmembrane transport
J4Z28_RS06585	COG0395	ABC-type sugar transport system, permease component
J4Z28_RS06595	COG0534	Mate efflux family protein
J4Z28_RS06600	COG1349	DNA-binding transcription factor activity
J4Z28_RS06605	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS06610	COG5002	protein histidine kinase activity
J4Z28_RS06615	COG0567	Dehydrogenase, E1 component
J4Z28_RS06620	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4Z28_RS06640	COG0714	Associated with various cellular activities
J4Z28_RS06645	COG4548	von Willebrand factor, type A
J4Z28_RS06650	COG1114	Component of the transport system for branched-chain amino acids
J4Z28_RS06655	COG3853	Toxic anion resistance protein (TelA)
J4Z28_RS06675	COG1278	Cold shock
J4Z28_RS06690	COG1131	(ABC) transporter
J4Z28_RS06710	COG1473	amidohydrolase
J4Z28_RS06715	COG2171	N-acyltransferase activity
J4Z28_RS06720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4Z28_RS06725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4Z28_RS06730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4Z28_RS06735	COG0527	aspartate kinase activity
J4Z28_RS06740	COG0488	(ABC) transporter
J4Z28_RS06745	COG2996	Protein conserved in bacteria
J4Z28_RS06750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J4Z28_RS06755	COG0573	inorganic phosphate transmembrane transporter activity
J4Z28_RS06760	COG0581	inorganic phosphate transmembrane transporter activity
J4Z28_RS06765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4Z28_RS06770	COG0704	Plays a role in the regulation of phosphate uptake
J4Z28_RS06810	COG2348	transferase activity, transferring amino-acyl groups
J4Z28_RS06815	COG2348	transferase activity, transferring amino-acyl groups
J4Z28_RS06825	COG0159	tryptophan synthase activity
J4Z28_RS06830	COG0133	tryptophan synthase activity
J4Z28_RS06835	COG0135	phosphoribosylanthranilate isomerase activity
J4Z28_RS06840	COG0134	indole-3-glycerol-phosphate synthase activity
J4Z28_RS06845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4Z28_RS06850	COG0512	Glutamine amidotransferase of anthranilate synthase
J4Z28_RS06850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4Z28_RS06855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4Z28_RS06860	COG0287	Prephenate dehydrogenase
J4Z28_RS06865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4Z28_RS06870	COG1942	4-Oxalocrotonate Tautomerase
J4Z28_RS06885	COG0392	lysyltransferase activity
J4Z28_RS06885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J4Z28_RS06890	COG0628	permease
J4Z28_RS06895	COG3711	transcriptional antiterminator
J4Z28_RS06900	COG1115	amino acid carrier protein
J4Z28_RS06905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4Z28_RS06910	COG0187	DNA topoisomerase II activity
J4Z28_RS06915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J4Z28_RS06920	COG4841	protein insertion into membrane
J4Z28_RS06925	COG0824	Thioesterase
J4Z28_RS06930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4Z28_RS06935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J4Z28_RS06940	COG1970	mechanosensitive ion channel activity
J4Z28_RS06945	COG0419	ATPase involved in DNA repair
J4Z28_RS06950	COG0420	3'-5' exonuclease activity
J4Z28_RS06955	COG4846	Membrane protein involved in cytochrome C biogenesis
J4Z28_RS06965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4Z28_RS06970	COG4224	UPF0291 protein
J4Z28_RS06980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J4Z28_RS06985	COG2340	Cysteine-rich secretory protein family
J4Z28_RS06990	COG0516	GMP reductase activity
J4Z28_RS06995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4Z28_RS07005	COG0753	catalase activity
J4Z28_RS07010	COG0833	amino acid
J4Z28_RS07030	COG0083	homoserine kinase activity
J4Z28_RS07035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4Z28_RS07040	COG0460	homoserine dehydrogenase
J4Z28_RS07045	COG0527	aspartate kinase activity
J4Z28_RS07060	COG1525	nuclease
J4Z28_RS07070	COG2197	response regulator
J4Z28_RS07075	COG4585	Histidine kinase
J4Z28_RS07085	COG1131	(ABC) transporter
J4Z28_RS07090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4Z28_RS07135	COG0174	glutamine synthetase
J4Z28_RS07140	COG0789	Transcriptional regulator
J4Z28_RS07145	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
J4Z28_RS07150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4Z28_RS07155	COG0386	Belongs to the glutathione peroxidase family
J4Z28_RS07160	COG1923	regulation of RNA biosynthetic process
J4Z28_RS07165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J4Z28_RS07175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J4Z28_RS07180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J4Z28_RS07185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J4Z28_RS07190	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
J4Z28_RS07195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4Z28_RS07200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4Z28_RS07210	COG4550	Control of competence regulator ComK, YlbF/YmcA
J4Z28_RS07215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4Z28_RS07225	COG4195	phage-related replication protein
J4Z28_RS07230	COG1013	pyruvate-flavodoxin oxidoreductase activity
J4Z28_RS07235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J4Z28_RS07235	COG0674	pyruvate-flavodoxin oxidoreductase activity
J4Z28_RS07240	COG1692	metallophosphoesterase
J4Z28_RS07250	COG1418	mRNA catabolic process
J4Z28_RS07255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J4Z28_RS07260	COG1058	Belongs to the CinA family
J4Z28_RS07260	COG1546	Belongs to the CinA family
J4Z28_RS07265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4Z28_RS07280	COG0300	oxidoreductase activity
J4Z28_RS07285	COG0612	Peptidase, M16
J4Z28_RS07290	COG0612	Peptidase, M16
J4Z28_RS07295	COG2188	Transcriptional regulator
J4Z28_RS07300	COG1674	ftsk spoiiie
J4Z28_RS07305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J4Z28_RS07310	COG1185	polyribonucleotide nucleotidyltransferase activity
J4Z28_RS07315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J4Z28_RS07320	COG0196	riboflavin kinase activity
J4Z28_RS07325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J4Z28_RS07330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J4Z28_RS07335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J4Z28_RS07340	COG1358	cellular component organization or biogenesis
J4Z28_RS07345	COG2740	Nucleic-acid-binding protein implicated in transcription termination
J4Z28_RS07350	COG0195	Participates in both transcription termination and antitermination
J4Z28_RS07355	COG0779	Required for maturation of 30S ribosomal subunits
J4Z28_RS07360	COG2176	DNA-directed DNA polymerase activity
J4Z28_RS07365	COG0442	prolyl-tRNA aminoacylation
J4Z28_RS07375	COG4589	Belongs to the CDS family
J4Z28_RS07380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4Z28_RS07385	COG0233	cytoplasmic translational termination
J4Z28_RS07390	COG0528	UMP kinase activity
J4Z28_RS07395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J4Z28_RS07400	COG0052	Belongs to the universal ribosomal protein uS2 family
J4Z28_RS07405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
J4Z28_RS07410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J4Z28_RS07415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J4Z28_RS07420	COG4974	Belongs to the 'phage' integrase family
J4Z28_RS07425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J4Z28_RS07430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4Z28_RS07435	COG0758	DNA mediated transformation
J4Z28_RS07445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J4Z28_RS07450	COG0045	succinate-CoA ligase (ADP-forming) activity
J4Z28_RS07455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J4Z28_RS07470	COG4485	Bacterial membrane protein, YfhO
J4Z28_RS07480	COG0335	large ribosomal subunit rRNA binding
J4Z28_RS07485	COG0336	Belongs to the RNA methyltransferase TrmD family
J4Z28_RS07490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J4Z28_RS07495	COG0228	four-way junction DNA binding
J4Z28_RS07500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4Z28_RS07505	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
J4Z28_RS07510	COG0552	protein localization to endoplasmic reticulum
J4Z28_RS07515	COG1196	nuclear chromosome segregation
J4Z28_RS07520	COG0571	ribonuclease III activity
J4Z28_RS07525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4Z28_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS07540	COG0416	fatty acid biosynthetic process
J4Z28_RS07545	COG1349	DNA-binding transcription factor activity
J4Z28_RS07550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4Z28_RS07555	COG1461	Dihydroxyacetone kinase
J4Z28_RS07560	COG1302	Protein conserved in bacteria
J4Z28_RS07565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J4Z28_RS07575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4Z28_RS07580	COG1162	GTPase activity
J4Z28_RS07590	COG0631	protein serine/threonine phosphatase activity
J4Z28_RS07595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J4Z28_RS07600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4Z28_RS07600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4Z28_RS07605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J4Z28_RS07610	COG0242	peptide deformylase activity
J4Z28_RS07620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4Z28_RS07625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4Z28_RS07630	COG1758	RNA polymerase activity
J4Z28_RS07635	COG0194	GDP metabolic process
J4Z28_RS07655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4Z28_RS07660	COG0284	orotidine-5'-phosphate decarboxylase activity
J4Z28_RS07665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4Z28_RS07670	COG0505	Belongs to the CarA family
J4Z28_RS07675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4Z28_RS07680	COG0540	Belongs to the ATCase OTCase family
J4Z28_RS07685	COG2233	PERMEase
J4Z28_RS07690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J4Z28_RS07695	COG0564	pseudouridine synthase activity
J4Z28_RS07700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J4Z28_RS07705	COG1388	LysM domain
J4Z28_RS07705	COG3942	CHAP domain
J4Z28_RS07715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4Z28_RS07720	COG3599	regulation of cell shape
J4Z28_RS07730	COG0762	integral membrane protein
J4Z28_RS07735	COG1799	cell septum assembly
J4Z28_RS07740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4Z28_RS07745	COG1496	oxidoreductase activity
J4Z28_RS07750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4Z28_RS07755	COG0849	cell division
J4Z28_RS07760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4Z28_RS07765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J4Z28_RS07770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4Z28_RS07775	COG0768	penicillin binding
J4Z28_RS07780	COG4839	cell division protein FtsL
J4Z28_RS07785	COG0275	rRNA processing
J4Z28_RS07790	COG2001	Belongs to the MraZ family
J4Z28_RS07795	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
J4Z28_RS07800	COG0454	-acetyltransferase
J4Z28_RS07805	COG1011	Hydrolase
J4Z28_RS07840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4Z28_RS07845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J4Z28_RS07850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4Z28_RS07855	COG1053	succinate dehydrogenase
J4Z28_RS07860	COG2009	succinate dehydrogenase
J4Z28_RS07870	COG0322	excinuclease ABC activity
J4Z28_RS07875	COG3118	belongs to the thioredoxin family
J4Z28_RS07880	COG1193	negative regulation of DNA recombination
J4Z28_RS07885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J4Z28_RS07885	COG1796	DNA polymerase
J4Z28_RS07895	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
J4Z28_RS07900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J4Z28_RS07905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Z28_RS07905	COG0072	phenylalanine-tRNA ligase activity
J4Z28_RS07910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J4Z28_RS07915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4Z28_RS07925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J4Z28_RS07935	COG1323	Belongs to the UPF0348 family
J4Z28_RS07940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4Z28_RS07945	COG0742	ribosomal rna small subunit methyltransferase
J4Z28_RS07955	COG4471	UPF0298 protein
J4Z28_RS07960	COG0584	glycerophosphoryl diester phosphodiesterase
J4Z28_RS07965	COG3679	Belongs to the UPF0342 family
J4Z28_RS07970	COG2340	Cysteine-rich secretory protein family
J4Z28_RS07980	COG0109	protoheme IX farnesyltransferase activity
J4Z28_RS07985	COG1612	heme a metabolic process
J4Z28_RS07995	COG0772	Belongs to the SEDS family
J4Z28_RS08000	COG4838	Belongs to the UPF0358 family
J4Z28_RS08005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J4Z28_RS08010	COG4896	Protein conserved in bacteria
J4Z28_RS08020	COG1217	gtp-binding protein TYPA
J4Z28_RS08030	COG0483	inositol monophosphate 1-phosphatase activity
J4Z28_RS08035	COG4493	Belongs to the UPF0637 family
J4Z28_RS08040	COG1914	H( )-stimulated, divalent metal cation uptake system
J4Z28_RS08065	COG1176	ABC-type spermidine putrescine transport system, permease component I
J4Z28_RS08070	COG3842	ATPase activity
J4Z28_RS08080	COG4476	Belongs to the UPF0223 family
J4Z28_RS08090	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4Z28_RS08095	COG0022	dehydrogenase e1 component
J4Z28_RS08100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4Z28_RS08110	COG0242	peptide deformylase activity
J4Z28_RS08115	COG5503	Protein of unknown function (DUF1447)
J4Z28_RS08120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J4Z28_RS08125	COG0569	domain protein
J4Z28_RS08130	COG1294	oxidase, subunit
J4Z28_RS08135	COG1271	oxidase subunit
J4Z28_RS08145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4Z28_RS08150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Z28_RS08160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4Z28_RS08175	COG4716	Myosin-crossreactive antigen
J4Z28_RS08185	COG4172	Belongs to the ABC transporter superfamily
J4Z28_RS08190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4Z28_RS08195	COG0151	Belongs to the GarS family
J4Z28_RS08200	COG0138	bifunctional purine biosynthesis protein purh
J4Z28_RS08205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4Z28_RS08210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4Z28_RS08215	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J4Z28_RS08220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4Z28_RS08225	COG0047	phosphoribosylformylglycinamidine synthase activity
J4Z28_RS08230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4Z28_RS08235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4Z28_RS08240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J4Z28_RS08245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J4Z28_RS08250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4Z28_RS08260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4Z28_RS08265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4Z28_RS08270	COG1845	cytochrome c oxidase, subunit III
J4Z28_RS08275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J4Z28_RS08290	COG1316	TRANSCRIPTIONal
J4Z28_RS08315	COG3594	Acyltransferase
J4Z28_RS08320	COG0436	Aminotransferase
J4Z28_RS08325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J4Z28_RS08335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J4Z28_RS08340	COG1169	isochorismate synthase
J4Z28_RS08345	COG1575	Belongs to the MenA family. Type 1 subfamily
J4Z28_RS08350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4Z28_RS08355	COG2314	TM2 domain
J4Z28_RS08365	COG1279	arginine transmembrane transporter activity
J4Z28_RS08410	COG4873	Protein conserved in bacteria
J4Z28_RS08420	COG0737	Belongs to the 5'-nucleotidase family
J4Z28_RS08425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4Z28_RS08430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4Z28_RS08435	COG0861	Integral membrane protein TerC family
J4Z28_RS08440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J4Z28_RS08450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J4Z28_RS08455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4Z28_RS08460	COG2814	Major facilitator Superfamily
J4Z28_RS08465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
J4Z28_RS08470	COG2382	esterase
J4Z28_RS08475	COG0628	permease
J4Z28_RS08535	COG0569	domain protein
J4Z28_RS08535	COG0475	glutathione-regulated potassium exporter activity
J4Z28_RS08540	COG2239	Acts as a magnesium transporter
J4Z28_RS08545	COG0564	pseudouridine synthase activity
J4Z28_RS08550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4Z28_RS08555	COG2357	RelA SpoT domain protein
J4Z28_RS08570	COG2346	COG2346, Truncated hemoglobins
J4Z28_RS08575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J4Z28_RS08580	COG1164	Oligoendopeptidase f
J4Z28_RS08590	COG4862	establishment of competence for transformation
J4Z28_RS08600	COG1393	Belongs to the ArsC family
J4Z28_RS08605	COG0180	Tryptophanyl-tRNA synthetase
J4Z28_RS08610	COG4166	transmembrane transport
J4Z28_RS08620	COG0444	Belongs to the ABC transporter superfamily
J4Z28_RS08625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4Z28_RS08630	COG0601	transmembrane transport
J4Z28_RS08645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4Z28_RS08660	COG0542	response to heat
J4Z28_RS08675	COG0561	phosphatase activity
J4Z28_RS08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4Z28_RS08700	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4Z28_RS08705	COG1074	ATP-dependent DNA helicase activity
J4Z28_RS08710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
J4Z28_RS08725	COG0398	Pfam SNARE associated Golgi protein
J4Z28_RS08730	COG0166	Belongs to the GPI family
J4Z28_RS08735	COG0137	argininosuccinate synthase activity
J4Z28_RS08740	COG0165	Argininosuccinate lyase
J4Z28_RS08745	COG0584	glycerophosphoryl diester phosphodiesterase
J4Z28_RS08755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4Z28_RS08765	COG1902	pentaerythritol trinitrate reductase activity
J4Z28_RS08770	COG1098	S1 RNA binding domain
J4Z28_RS08775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4Z28_RS08785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4Z28_RS08785	COG2111	Na H antiporter
J4Z28_RS08790	COG2111	Na H antiporter
J4Z28_RS08795	COG1006	Multisubunit Na H antiporter MnhC subunit
J4Z28_RS08800	COG0651	ATP synthesis coupled electron transport
J4Z28_RS08805	COG1863	multisubunit Na H antiporter MnhE subunit
J4Z28_RS08810	COG2212	antiporter activity
J4Z28_RS08815	COG1320	monovalent cation:proton antiporter activity
J4Z28_RS08825	COG2050	protein possibly involved in aromatic compounds catabolism
J4Z28_RS08830	COG2056	Na+-H+ antiporter family
J4Z28_RS08835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J4Z28_RS08840	COG1252	NADH dehydrogenase
J4Z28_RS08845	COG0316	Belongs to the HesB IscA family
J4Z28_RS08850	COG4844	belongs to the
J4Z28_RS08855	COG1252	NADH dehydrogenase
J4Z28_RS08860	COG4837	Protein of unknown function (DUF1462)
J4Z28_RS08865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J4Z28_RS08870	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
J4Z28_RS08875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4Z28_RS08880	COG1696	Membrane protein involved in D-alanine export
J4Z28_RS08885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4Z28_RS08895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4Z28_RS08900	COG0647	UMP catabolic process
J4Z28_RS08905	COG2445	Protein of unknown function DUF86
J4Z28_RS08915	COG4470	Protein conserved in bacteria
J4Z28_RS08920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J4Z28_RS08925	COG0737	Belongs to the 5'-nucleotidase family
J4Z28_RS08930	COG0730	response to heat
J4Z28_RS08935	COG1801	Protein of unknown function DUF72
J4Z28_RS08940	COG1253	flavin adenine dinucleotide binding
J4Z28_RS08990	COG4195	phage-related replication protein
J4Z28_RS09115	COG0756	dUTP diphosphatase activity
J4Z28_RS09165	COG1484	DNA-dependent DNA replication
J4Z28_RS09265	COG4974	Belongs to the 'phage' integrase family
J4Z28_RS09270	COG0719	Fe-S assembly protein
J4Z28_RS09275	COG0822	iron-sulfur transferase activity
J4Z28_RS09280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4Z28_RS09285	COG0719	Fe-S assembly protein
J4Z28_RS09290	COG0396	ATPase activity
J4Z28_RS09300	COG3237	CsbD-like
J4Z28_RS09310	COG1464	Belongs to the NlpA lipoprotein family
J4Z28_RS09315	COG2011	ABC-type metal ion transport system permease component
J4Z28_RS09320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4Z28_RS09330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
J4Z28_RS09335	COG0509	glycine decarboxylation via glycine cleavage system
J4Z28_RS09340	COG1393	Belongs to the ArsC family
J4Z28_RS09345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4Z28_RS09355	COG0710	3-dehydroquinate dehydratase activity
J4Z28_RS09360	COG1764	response to oxidative stress
J4Z28_RS09415	COG4195	phage-related replication protein
J4Z28_RS09430	COG1278	Cold shock
J4Z28_RS09455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4Z28_RS09495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J4Z28_RS09500	COG0557	exoribonuclease II activity
J4Z28_RS09505	COG1647	Serine aminopeptidase, S33
J4Z28_RS09510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4Z28_RS09520	COG0148	phosphopyruvate hydratase activity
J4Z28_RS09525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J4Z28_RS09530	COG0149	triose-phosphate isomerase activity
J4Z28_RS09535	COG0126	phosphoglycerate kinase activity
J4Z28_RS09540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4Z28_RS09560	COG1090	epimerase
J4Z28_RS09570	COG0740	serine-type endopeptidase activity
J4Z28_RS09580	COG1481	regulation of sporulation
J4Z28_RS09585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J4Z28_RS09590	COG1660	Displays ATPase and GTPase activities
J4Z28_RS09595	COG0492	ferredoxin-NADP+ reductase activity
J4Z28_RS09610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J4Z28_RS09615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J4Z28_RS09620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4Z28_RS09625	COG0556	nucleotide-excision repair
J4Z28_RS09640	COG3942	CHAP domain
J4Z28_RS09640	COG1388	LysM domain
J4Z28_RS09650	COG0653	protein targeting
J4Z28_RS09655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4Z28_RS09660	COG1040	competence protein
J4Z28_RS09665	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
J4Z28_RS09675	COG1739	Uncharacterized protein family UPF0029
J4Z28_RS09680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4Z28_RS09685	COG2199	diguanylate cyclase activity
J4Z28_RS09700	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4Z28_RS09705	COG1929	Belongs to the glycerate kinase type-1 family
J4Z28_RS09725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J4Z28_RS09740	COG4604	ABC transporter, ATP-binding protein
J4Z28_RS09745	COG4605	iron ion homeostasis
J4Z28_RS09750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4Z28_RS09760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4Z28_RS09765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4Z28_RS09770	COG1780	Probably involved in ribonucleotide reductase function
J4Z28_RS09780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4Z28_RS09785	COG3104	oligopeptide transport
J4Z28_RS09795	COG1597	lipid kinase activity
J4Z28_RS09800	COG1454	alcohol dehydrogenase
J4Z28_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
J4Z28_RS09805	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
J4Z28_RS09810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J4Z28_RS09815	COG1174	glycine betaine transport
J4Z28_RS09825	COG0514	ATP-dependent DNA helicase (RecQ)
J4Z28_RS09830	COG0488	(ABC) transporter
J4Z28_RS09845	COG1368	sulfuric ester hydrolase activity
J4Z28_RS09855	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J4Z28_RS09870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4Z28_RS09880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J4Z28_RS09885	COG0720	synthase
J4Z28_RS09890	COG0602	queuosine metabolic process
J4Z28_RS09915	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS09920	COG5002	protein histidine kinase activity
J4Z28_RS09925	COG0463	Glycosyl transferase, family 2
J4Z28_RS09930	COG0656	L-ascorbic acid biosynthetic process
J4Z28_RS09935	COG1253	flavin adenine dinucleotide binding
J4Z28_RS09940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4Z28_RS09945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Z28_RS09945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4Z28_RS09945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4Z28_RS09950	COG1105	Belongs to the carbohydrate kinase PfkB family
J4Z28_RS09955	COG1349	DNA-binding transcription factor activity
J4Z28_RS09960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4Z28_RS09985	COG0415	Belongs to the DNA photolyase family
J4Z28_RS09990	COG0471	metal ion transport
J4Z28_RS09995	COG0039	L-malate dehydrogenase activity
J4Z28_RS10015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J4Z28_RS10020	COG4988	ABC transporter
J4Z28_RS10025	COG1968	undecaprenyl-diphosphatase activity
J4Z28_RS10040	COG1671	Belongs to the UPF0178 family
J4Z28_RS10045	COG1611	Belongs to the LOG family
J4Z28_RS10070	COG2839	Protein conserved in bacteria
J4Z28_RS10075	COG2814	Major facilitator Superfamily
J4Z28_RS10080	COG0583	DNA-binding transcription factor activity
J4Z28_RS10100	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
J4Z28_RS10110	COG0217	transcriptional regulatory protein
J4Z28_RS10130	COG1388	LysM domain
J4Z28_RS10130	COG3942	CHAP domain
J4Z28_RS10135	COG0306	phosphate transporter
J4Z28_RS10140	COG1392	Phosphate transport regulator
J4Z28_RS10145	COG0577	efflux transmembrane transporter activity
J4Z28_RS10150	COG1136	(ABC) transporter
J4Z28_RS10155	COG2205	protein histidine kinase activity
J4Z28_RS10160	COG0745	RESPONSE REGULATOR receiver
J4Z28_RS10165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4Z28_RS10180	COG3949	Membrane
J4Z28_RS10190	COG1120	ATPase activity
J4Z28_RS10195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4Z28_RS10200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4Z28_RS10205	COG1132	(ABC) transporter
J4Z28_RS10210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4Z28_RS10220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4Z28_RS10225	COG1682	transport, permease protein
J4Z28_RS10230	COG1134	teichoic acid transport
J4Z28_RS10235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J4Z28_RS10245	COG1321	iron dependent repressor
J4Z28_RS10250	COG1121	(ABC) transporter
J4Z28_RS10255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4Z28_RS10260	COG0803	Belongs to the bacterial solute-binding protein 9 family
J4Z28_RS10270	COG1320	monovalent cation:proton antiporter activity
J4Z28_RS10275	COG2212	antiporter activity
J4Z28_RS10280	COG1863	multisubunit Na H antiporter MnhE subunit
J4Z28_RS10285	COG0651	ATP synthesis coupled electron transport
J4Z28_RS10290	COG1006	Multisubunit Na H antiporter MnhC subunit
J4Z28_RS10295	COG2111	Na H antiporter
J4Z28_RS10300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4Z28_RS10300	COG2111	Na H antiporter
J4Z28_RS10330	COG0596	Alpha beta hydrolase
J4Z28_RS10350	COG0546	phosphoglycolate phosphatase activity
J4Z28_RS10355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4Z28_RS10360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4Z28_RS10370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4Z28_RS10375	COG0018	arginyl-trna synthetase
J4Z28_RS10390	COG1064	alcohol dehydrogenase
J4Z28_RS10395	COG3875	lactate racemase activity
J4Z28_RS10400	COG1606	tRNA processing
J4Z28_RS10405	COG1691	(AIR) carboxylase
J4Z28_RS10410	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
J4Z28_RS10420	COG1078	dGTPase activity
J4Z28_RS10430	COG0667	Aldo Keto reductase
J4Z28_RS10440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4Z28_RS10445	COG4844	belongs to the
J4Z28_RS10465	COG0095	Lipoate-protein ligase
J4Z28_RS10470	COG0280	phosphate acetyltransferase
J4Z28_RS10475	COG3253	May function as heme-dependent peroxidase
J4Z28_RS10495	COG0531	amino acid
J4Z28_RS10510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J4Z28_RS10520	COG0351	phosphomethylpyrimidine kinase
J4Z28_RS10540	COG0183	Belongs to the thiolase family
J4Z28_RS10545	COG0318	PFAM AMP-dependent synthetase and ligase
J4Z28_RS10555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4Z28_RS10560	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
J4Z28_RS10565	COG0363	glucosamine-6-phosphate deaminase activity
J4Z28_RS10575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J4Z28_RS10580	COG1469	GTP cyclohydrolase I activity
J4Z28_RS10610	COG0561	phosphatase activity
J4Z28_RS10620	COG1428	Deoxynucleoside kinase
J4Z28_RS10625	COG1428	Deoxynucleoside kinase
J4Z28_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
J4Z28_RS10640	COG0546	phosphoglycolate phosphatase activity
J4Z28_RS10645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4Z28_RS10650	COG1063	alcohol dehydrogenase
J4Z28_RS10655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J4Z28_RS10660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4Z28_RS10665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4Z28_RS10685	COG1473	amidohydrolase
J4Z28_RS10690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J4Z28_RS10695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4Z28_RS10705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J4Z28_RS10715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J4Z28_RS10720	COG0085	RNA polymerase activity
J4Z28_RS10725	COG2813	Specifically methylates the guanine in position
J4Z28_RS10730	COG0222	ribosome binding
J4Z28_RS10735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J4Z28_RS10740	COG0081	regulation of translation
J4Z28_RS10745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J4Z28_RS10750	COG0250	Participates in transcription elongation, termination and antitermination
J4Z28_RS10755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4Z28_RS10760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4Z28_RS10770	COG3688	RNA-binding protein containing a PIN domain
J4Z28_RS10775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4Z28_RS10780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
J4Z28_RS10785	COG0215	cysteine-tRNA ligase activity
J4Z28_RS10790	COG1045	serine acetyltransferase
J4Z28_RS10795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4Z28_RS10800	COG4956	integral membrane protein (PIN domain superfamily)
J4Z28_RS10805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J4Z28_RS10810	COG0542	response to heat
J4Z28_RS10815	COG3869	Catalyzes the specific phosphorylation of arginine residues in
J4Z28_RS10820	COG3880	PFAM UvrB UvrC protein
J4Z28_RS10825	COG4463	regulation of RNA biosynthetic process
J4Z28_RS10830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4Z28_RS10840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
J4Z28_RS10845	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
J4Z28_RS10850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4Z28_RS10935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J4Z28_RS10940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4Z28_RS10945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4Z28_RS10950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4Z28_RS10955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4Z28_RS10960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J4Z28_RS10965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4Z28_RS10970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J4Z28_RS10975	COG0037	tRNA processing
J4Z28_RS10980	COG1098	S1 RNA binding domain
J4Z28_RS10990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J4Z28_RS10995	COG3956	TIGRFAM MazG family protein
J4Z28_RS11000	COG2244	polysaccharide biosynthetic process
J4Z28_RS11005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4Z28_RS11010	COG0193	aminoacyl-tRNA hydrolase activity
J4Z28_RS11015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J4Z28_RS11020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4Z28_RS11025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J4Z28_RS11030	COG2088	sporulation resulting in formation of a cellular spore
J4Z28_RS11035	COG0251	oxidation-reduction process
J4Z28_RS11040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4Z28_RS11045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J4Z28_RS11050	COG4466	Protein conserved in bacteria
J4Z28_RS11055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4Z28_RS11060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
J4Z28_RS11065	COG0084	hydrolase, TatD family'
J4Z28_RS11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Z28_RS11070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4Z28_RS11075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J4Z28_RS11080	COG2827	Endonuclease containing a URI domain
J4Z28_RS11085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J4Z28_RS11090	COG4467	Involved in initiation control of chromosome replication
J4Z28_RS11095	COG1774	PSP1 C-terminal conserved region
J4Z28_RS11100	COG0470	DNA polymerase III
J4Z28_RS11105	COG3870	Protein conserved in bacteria
J4Z28_RS11110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4Z28_RS11115	COG1982	Orn Lys Arg decarboxylase major
J4Z28_RS11140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4Z28_RS11145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J4Z28_RS11150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4Z28_RS11170	COG2855	membrane
J4Z28_RS11175	COG0583	DNA-binding transcription factor activity
J4Z28_RS11185	COG0493	'glutamate synthase
J4Z28_RS11190	COG0067	glutamate synthase
J4Z28_RS11190	COG0070	glutamate synthase
J4Z28_RS11190	COG0069	glutamate synthase activity
J4Z28_RS11195	COG0583	DNA-binding transcription factor activity
J4Z28_RS11220	COG0438	transferase activity, transferring glycosyl groups
J4Z28_RS11225	COG1388	LysM domain
J4Z28_RS11225	COG3942	CHAP domain
J4Z28_RS11235	COG2011	ABC-type metal ion transport system permease component
J4Z28_RS11240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4Z28_RS11245	COG0626	cystathionine gamma-synthase activity
J4Z28_RS11250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4Z28_RS11260	COG0733	neurotransmitter:sodium symporter activity
J4Z28_RS11270	COG1647	Serine aminopeptidase, S33
J4Z28_RS11285	COG5609	conserved protein (DUF2294)
J4Z28_RS11290	COG3002	Belongs to the UPF0753 family
J4Z28_RS11295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4Z28_RS11310	COG0523	cobalamin synthesis protein
J4Z28_RS11360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4Z28_RS11360	COG0519	Catalyzes the synthesis of GMP from XMP
J4Z28_RS11365	COG0517	IMP dehydrogenase activity
J4Z28_RS11365	COG0516	GMP reductase activity
J4Z28_RS11370	COG2233	PERMEase
J4Z28_RS11375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4Z28_RS11390	COG5183	chlorophyll binding
J4Z28_RS11395	COG1823	symporter activity
J4Z28_RS11400	COG0778	Nitroreductase
J4Z28_RS11410	COG0450	alkyl hydroperoxide reductase
J4Z28_RS11415	COG3634	alkyl hydroperoxide reductase activity
J4Z28_RS11435	COG1280	lysine exporter protein (LysE YggA)
J4Z28_RS11455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J4Z28_RS11465	COG0360	Binds together with S18 to 16S ribosomal RNA
J4Z28_RS11480	COG0012	GTP binding
J4Z28_RS11485	COG4481	Protein conserved in bacteria
J4Z28_RS11490	COG0668	transmembrane transport
J4Z28_RS11495	COG1475	DNA binding
J4Z28_RS11500	COG0626	cystathionine gamma-synthase activity
J4Z28_RS11505	COG0626	cystathionine gamma-synthase activity
J4Z28_RS11510	COG0646	methionine synthase
J4Z28_RS11510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4Z28_RS11515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
J4Z28_RS11525	COG0183	Belongs to the thiolase family
J4Z28_RS11540	COG1476	TRANSCRIPTIONal
J4Z28_RS11550	COG4555	ABC transporter
J4Z28_RS11705	COG1136	(ABC) transporter
J4Z28_RS11710	COG0577	efflux transmembrane transporter activity
J4Z28_RS11725	COG0577	efflux transmembrane transporter activity
J4Z28_RS11730	COG1136	(ABC) transporter
J4Z28_RS11765	COG1475	DNA binding
J4Z28_RS11770	COG0357	Ribosomal RNA small subunit methyltransferase G
J4Z28_RS11775	COG0445	tRNA wobble uridine modification
J4Z28_RS11780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J4Z28_RS11785	COG0594	ribonuclease P activity
J4Z28_RS11820	COG1131	(ABC) transporter
J4Z28_RS11845	COG1683	Conserved Protein
J4Z28_RS11860	COG1131	(ABC) transporter