locus-tag	class	description
KFV43_RS00005	COG0592	DNA-directed DNA polymerase activity
KFV43_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFV43_RS00020	COG0594	ribonuclease P activity
KFV43_RS00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFV43_RS00030	COG0445	tRNA wobble uridine modification
KFV43_RS00035	COG0357	Ribosomal RNA small subunit methyltransferase G
KFV43_RS00040	COG1475	DNA binding
KFV43_RS00075	COG1136	(ABC) transporter
KFV43_RS00080	COG0577	efflux transmembrane transporter activity
KFV43_RS00095	COG0577	efflux transmembrane transporter activity
KFV43_RS00100	COG1136	(ABC) transporter
KFV43_RS00140	COG1476	TRANSCRIPTIONal
KFV43_RS00155	COG0183	Belongs to the thiolase family
KFV43_RS00165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFV43_RS00170	COG0646	methionine synthase
KFV43_RS00170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KFV43_RS00175	COG0626	cystathionine gamma-synthase activity
KFV43_RS00180	COG0626	cystathionine gamma-synthase activity
KFV43_RS00185	COG1475	DNA binding
KFV43_RS00190	COG0668	transmembrane transport
KFV43_RS00195	COG4481	Protein conserved in bacteria
KFV43_RS00200	COG0012	GTP binding
KFV43_RS00215	COG0360	Binds together with S18 to 16S ribosomal RNA
KFV43_RS00225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFV43_RS00240	COG1280	lysine exporter protein (LysE YggA)
KFV43_RS00260	COG3634	alkyl hydroperoxide reductase activity
KFV43_RS00265	COG0450	alkyl hydroperoxide reductase
KFV43_RS00275	COG0778	Nitroreductase
KFV43_RS00280	COG1823	symporter activity
KFV43_RS00285	COG5183	chlorophyll binding
KFV43_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV43_RS00305	COG2233	PERMEase
KFV43_RS00310	COG0516	GMP reductase activity
KFV43_RS00310	COG0517	IMP dehydrogenase activity
KFV43_RS00315	COG0519	Catalyzes the synthesis of GMP from XMP
KFV43_RS00315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFV43_RS00355	COG0523	cobalamin synthesis protein
KFV43_RS00375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV43_RS00380	COG3002	Belongs to the UPF0753 family
KFV43_RS00385	COG5609	conserved protein (DUF2294)
KFV43_RS00400	COG1647	Serine aminopeptidase, S33
KFV43_RS00410	COG0733	neurotransmitter:sodium symporter activity
KFV43_RS00420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFV43_RS00425	COG0626	cystathionine gamma-synthase activity
KFV43_RS00430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFV43_RS00435	COG2011	ABC-type metal ion transport system permease component
KFV43_RS00445	COG1388	LysM domain
KFV43_RS00445	COG3942	CHAP domain
KFV43_RS00450	COG0438	transferase activity, transferring glycosyl groups
KFV43_RS00475	COG0583	DNA-binding transcription factor activity
KFV43_RS00480	COG0070	glutamate synthase
KFV43_RS00480	COG0069	glutamate synthase activity
KFV43_RS00480	COG0067	glutamate synthase
KFV43_RS00485	COG0493	'glutamate synthase
KFV43_RS00495	COG0583	DNA-binding transcription factor activity
KFV43_RS00500	COG2855	membrane
KFV43_RS00520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFV43_RS00525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFV43_RS00530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFV43_RS00555	COG1982	Orn Lys Arg decarboxylase major
KFV43_RS00560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFV43_RS00565	COG3870	Protein conserved in bacteria
KFV43_RS00570	COG0470	DNA polymerase III
KFV43_RS00575	COG1774	PSP1 C-terminal conserved region
KFV43_RS00580	COG4467	Involved in initiation control of chromosome replication
KFV43_RS00585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KFV43_RS00590	COG2827	Endonuclease containing a URI domain
KFV43_RS00595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFV43_RS00600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV43_RS00600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV43_RS00605	COG0084	hydrolase, TatD family'
KFV43_RS00610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFV43_RS00615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFV43_RS00620	COG4466	Protein conserved in bacteria
KFV43_RS00625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFV43_RS00630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV43_RS00635	COG0251	oxidation-reduction process
KFV43_RS00640	COG2088	sporulation resulting in formation of a cellular spore
KFV43_RS00645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFV43_RS00650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFV43_RS00655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFV43_RS00660	COG0193	aminoacyl-tRNA hydrolase activity
KFV43_RS00665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFV43_RS00670	COG2244	polysaccharide biosynthetic process
KFV43_RS00675	COG3956	TIGRFAM MazG family protein
KFV43_RS00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFV43_RS00690	COG1098	S1 RNA binding domain
KFV43_RS00695	COG0037	tRNA processing
KFV43_RS00700	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KFV43_RS00705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFV43_RS00710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFV43_RS00715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFV43_RS00720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFV43_RS00725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFV43_RS00730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFV43_RS00735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFV43_RS00805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFV43_RS00810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KFV43_RS00815	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KFV43_RS00825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFV43_RS00830	COG4463	regulation of RNA biosynthetic process
KFV43_RS00835	COG3880	PFAM UvrB UvrC protein
KFV43_RS00840	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KFV43_RS00845	COG0542	response to heat
KFV43_RS00850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFV43_RS00855	COG4956	integral membrane protein (PIN domain superfamily)
KFV43_RS00860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFV43_RS00865	COG1045	serine acetyltransferase
KFV43_RS00870	COG0215	cysteine-tRNA ligase activity
KFV43_RS00875	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KFV43_RS00880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFV43_RS00885	COG3688	RNA-binding protein containing a PIN domain
KFV43_RS00895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFV43_RS00900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFV43_RS00905	COG0250	Participates in transcription elongation, termination and antitermination
KFV43_RS00910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFV43_RS00915	COG0081	regulation of translation
KFV43_RS00920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFV43_RS00925	COG0222	ribosome binding
KFV43_RS00930	COG2813	Specifically methylates the guanine in position
KFV43_RS00935	COG0085	RNA polymerase activity
KFV43_RS00940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFV43_RS00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFV43_RS00960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFV43_RS00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFV43_RS00970	COG1473	amidohydrolase
KFV43_RS00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFV43_RS00995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFV43_RS01000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFV43_RS01005	COG1063	alcohol dehydrogenase
KFV43_RS01010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS01015	COG0546	phosphoglycolate phosphatase activity
KFV43_RS01020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV43_RS01025	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS01030	COG1428	Deoxynucleoside kinase
KFV43_RS01035	COG1428	Deoxynucleoside kinase
KFV43_RS01045	COG0561	phosphatase activity
KFV43_RS01050	COG0431	NADPH-dependent FMN reductase
KFV43_RS01075	COG1469	GTP cyclohydrolase I activity
KFV43_RS01080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KFV43_RS01090	COG0363	glucosamine-6-phosphate deaminase activity
KFV43_RS01095	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KFV43_RS01110	COG0318	PFAM AMP-dependent synthetase and ligase
KFV43_RS01115	COG0183	Belongs to the thiolase family
KFV43_RS01135	COG0351	phosphomethylpyrimidine kinase
KFV43_RS01145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFV43_RS01155	COG2363	Small membrane protein
KFV43_RS01160	COG0531	amino acid
KFV43_RS01185	COG3253	May function as heme-dependent peroxidase
KFV43_RS01190	COG0280	phosphate acetyltransferase
KFV43_RS01195	COG0095	Lipoate-protein ligase
KFV43_RS01215	COG4844	belongs to the
KFV43_RS01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV43_RS01230	COG0667	Aldo Keto reductase
KFV43_RS01240	COG1078	dGTPase activity
KFV43_RS01250	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KFV43_RS01255	COG1691	(AIR) carboxylase
KFV43_RS01260	COG1606	tRNA processing
KFV43_RS01265	COG3875	lactate racemase activity
KFV43_RS01270	COG1064	alcohol dehydrogenase
KFV43_RS01285	COG0018	arginyl-trna synthetase
KFV43_RS01290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFV43_RS01300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFV43_RS01305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV43_RS01310	COG0546	phosphoglycolate phosphatase activity
KFV43_RS01330	COG0596	Alpha beta hydrolase
KFV43_RS01360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV43_RS01360	COG2111	Na H antiporter
KFV43_RS01365	COG2111	Na H antiporter
KFV43_RS01370	COG1006	Multisubunit Na H antiporter MnhC subunit
KFV43_RS01375	COG0651	ATP synthesis coupled electron transport
KFV43_RS01380	COG1863	multisubunit Na H antiporter MnhE subunit
KFV43_RS01385	COG2212	antiporter activity
KFV43_RS01390	COG1320	monovalent cation:proton antiporter activity
KFV43_RS01400	COG0803	Belongs to the bacterial solute-binding protein 9 family
KFV43_RS01405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFV43_RS01410	COG1121	(ABC) transporter
KFV43_RS01415	COG1321	iron dependent repressor
KFV43_RS01425	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KFV43_RS01430	COG1134	teichoic acid transport
KFV43_RS01435	COG1682	transport, permease protein
KFV43_RS01440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS01450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KFV43_RS01455	COG1132	(ABC) transporter
KFV43_RS01465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFV43_RS01470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFV43_RS01475	COG1120	ATPase activity
KFV43_RS01485	COG3949	Membrane
KFV43_RS01500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFV43_RS01505	COG0745	RESPONSE REGULATOR receiver
KFV43_RS01510	COG2205	protein histidine kinase activity
KFV43_RS01515	COG1136	(ABC) transporter
KFV43_RS01520	COG0577	efflux transmembrane transporter activity
KFV43_RS01525	COG1392	Phosphate transport regulator
KFV43_RS01530	COG0306	phosphate transporter
KFV43_RS01535	COG3942	CHAP domain
KFV43_RS01535	COG1388	LysM domain
KFV43_RS01555	COG0217	transcriptional regulatory protein
KFV43_RS01565	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KFV43_RS01585	COG0583	DNA-binding transcription factor activity
KFV43_RS01590	COG2814	Major facilitator Superfamily
KFV43_RS01595	COG2839	Protein conserved in bacteria
KFV43_RS01620	COG1611	Belongs to the LOG family
KFV43_RS01625	COG1671	Belongs to the UPF0178 family
KFV43_RS01640	COG1968	undecaprenyl-diphosphatase activity
KFV43_RS01645	COG4988	ABC transporter
KFV43_RS01650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KFV43_RS01670	COG0039	L-malate dehydrogenase activity
KFV43_RS01675	COG0471	metal ion transport
KFV43_RS01685	COG0415	Belongs to the DNA photolyase family
KFV43_RS01710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KFV43_RS01715	COG1349	DNA-binding transcription factor activity
KFV43_RS01720	COG1105	Belongs to the carbohydrate kinase PfkB family
KFV43_RS01725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV43_RS01725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV43_RS01725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV43_RS01730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KFV43_RS01735	COG1253	flavin adenine dinucleotide binding
KFV43_RS01740	COG0656	L-ascorbic acid biosynthetic process
KFV43_RS01745	COG0463	Glycosyl transferase, family 2
KFV43_RS01750	COG5002	protein histidine kinase activity
KFV43_RS01755	COG0745	RESPONSE REGULATOR receiver
KFV43_RS01780	COG0602	queuosine metabolic process
KFV43_RS01785	COG0720	synthase
KFV43_RS01790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFV43_RS01800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFV43_RS01815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KFV43_RS01825	COG1368	sulfuric ester hydrolase activity
KFV43_RS01840	COG0488	(ABC) transporter
KFV43_RS01845	COG0514	ATP-dependent DNA helicase (RecQ)
KFV43_RS01855	COG1174	glycine betaine transport
KFV43_RS01860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFV43_RS01865	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
KFV43_RS01870	COG1454	alcohol dehydrogenase
KFV43_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS01875	COG1597	lipid kinase activity
KFV43_RS01885	COG3104	oligopeptide transport
KFV43_RS01890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFV43_RS01900	COG1780	Probably involved in ribonucleotide reductase function
KFV43_RS01905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV43_RS01910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV43_RS01920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV43_RS01930	COG4604	ABC transporter, ATP-binding protein
KFV43_RS01945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFV43_RS01965	COG1929	Belongs to the glycerate kinase type-1 family
KFV43_RS01970	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFV43_RS01985	COG2199	diguanylate cyclase activity
KFV43_RS01990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFV43_RS01995	COG1739	Uncharacterized protein family UPF0029
KFV43_RS02005	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KFV43_RS02010	COG1040	competence protein
KFV43_RS02015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFV43_RS02020	COG0653	protein targeting
KFV43_RS02030	COG1388	LysM domain
KFV43_RS02030	COG3942	CHAP domain
KFV43_RS02045	COG0556	nucleotide-excision repair
KFV43_RS02050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFV43_RS02055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFV43_RS02060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFV43_RS02075	COG0492	ferredoxin-NADP+ reductase activity
KFV43_RS02080	COG1660	Displays ATPase and GTPase activities
KFV43_RS02085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KFV43_RS02090	COG1481	regulation of sporulation
KFV43_RS02100	COG0740	serine-type endopeptidase activity
KFV43_RS02110	COG1090	epimerase
KFV43_RS02130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFV43_RS02135	COG0126	phosphoglycerate kinase activity
KFV43_RS02140	COG0149	triose-phosphate isomerase activity
KFV43_RS02145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFV43_RS02150	COG0148	phosphopyruvate hydratase activity
KFV43_RS02160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFV43_RS02165	COG1647	Serine aminopeptidase, S33
KFV43_RS02170	COG0557	exoribonuclease II activity
KFV43_RS02175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFV43_RS02215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFV43_RS02245	COG1278	Cold shock
KFV43_RS02260	COG4195	phage-related replication protein
KFV43_RS02305	COG1764	response to oxidative stress
KFV43_RS02310	COG0710	3-dehydroquinate dehydratase activity
KFV43_RS02320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFV43_RS02325	COG1393	Belongs to the ArsC family
KFV43_RS02330	COG0509	glycine decarboxylation via glycine cleavage system
KFV43_RS02335	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFV43_RS02345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFV43_RS02350	COG2011	ABC-type metal ion transport system permease component
KFV43_RS02355	COG1464	Belongs to the NlpA lipoprotein family
KFV43_RS02365	COG3237	CsbD-like
KFV43_RS02375	COG0396	ATPase activity
KFV43_RS02380	COG0719	Fe-S assembly protein
KFV43_RS02385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFV43_RS02390	COG0822	iron-sulfur transferase activity
KFV43_RS02395	COG0719	Fe-S assembly protein
KFV43_RS02410	COG1253	flavin adenine dinucleotide binding
KFV43_RS02415	COG1801	Protein of unknown function DUF72
KFV43_RS02420	COG0730	response to heat
KFV43_RS02425	COG0737	Belongs to the 5'-nucleotidase family
KFV43_RS02430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFV43_RS02435	COG4470	Protein conserved in bacteria
KFV43_RS02445	COG2445	Protein of unknown function DUF86
KFV43_RS02450	COG0647	UMP catabolic process
KFV43_RS02455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV43_RS02465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KFV43_RS02470	COG1696	Membrane protein involved in D-alanine export
KFV43_RS02475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFV43_RS02480	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KFV43_RS02485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFV43_RS02490	COG4837	Protein of unknown function (DUF1462)
KFV43_RS02495	COG1252	NADH dehydrogenase
KFV43_RS02500	COG4844	belongs to the
KFV43_RS02505	COG0316	Belongs to the HesB IscA family
KFV43_RS02510	COG1252	NADH dehydrogenase
KFV43_RS02515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFV43_RS02520	COG2056	Na+-H+ antiporter family
KFV43_RS02525	COG2050	protein possibly involved in aromatic compounds catabolism
KFV43_RS02535	COG1320	monovalent cation:proton antiporter activity
KFV43_RS02540	COG2212	antiporter activity
KFV43_RS02545	COG1863	multisubunit Na H antiporter MnhE subunit
KFV43_RS02550	COG0651	ATP synthesis coupled electron transport
KFV43_RS02555	COG1006	Multisubunit Na H antiporter MnhC subunit
KFV43_RS02560	COG2111	Na H antiporter
KFV43_RS02565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV43_RS02565	COG2111	Na H antiporter
KFV43_RS02575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFV43_RS02580	COG1098	S1 RNA binding domain
KFV43_RS02585	COG1902	pentaerythritol trinitrate reductase activity
KFV43_RS02595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFV43_RS02605	COG0584	glycerophosphoryl diester phosphodiesterase
KFV43_RS02610	COG0165	Argininosuccinate lyase
KFV43_RS02615	COG0137	argininosuccinate synthase activity
KFV43_RS02620	COG0166	Belongs to the GPI family
KFV43_RS02625	COG0398	Pfam SNARE associated Golgi protein
KFV43_RS02640	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KFV43_RS02645	COG1074	ATP-dependent DNA helicase activity
KFV43_RS02650	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFV43_RS02675	COG2814	Major facilitator Superfamily
KFV43_RS02690	COG2348	transferase activity, transferring amino-acyl groups
KFV43_RS02695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFV43_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS02720	COG4975	Glucose uptake
KFV43_RS02725	COG0551	DNA topoisomerase type I activity
KFV43_RS02725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFV43_RS02730	COG2252	PERMEase
KFV43_RS02745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFV43_RS02750	COG0088	Forms part of the polypeptide exit tunnel
KFV43_RS02755	COG0089	rRNA binding
KFV43_RS02760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFV43_RS02765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFV43_RS02770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFV43_RS02775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFV43_RS02780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFV43_RS02790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFV43_RS02795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFV43_RS02800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFV43_RS02805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFV43_RS02810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFV43_RS02815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFV43_RS02820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFV43_RS02825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFV43_RS02830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFV43_RS02835	COG1841	ribosomal large subunit assembly
KFV43_RS02840	COG0200	Binds to the 23S rRNA
KFV43_RS02845	COG0201	protein transport
KFV43_RS02850	COG0563	adenylate kinase activity
KFV43_RS02855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFV43_RS02860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFV43_RS02865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFV43_RS02870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFV43_RS02875	COG0202	RNA polymerase activity
KFV43_RS02880	COG0203	ribosomal protein L17
KFV43_RS02885	COG1122	ATPase activity
KFV43_RS02890	COG1122	ATPase activity
KFV43_RS02900	COG0101	tRNA pseudouridine synthase activity
KFV43_RS02905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFV43_RS02910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFV43_RS02915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KFV43_RS02920	COG1349	DNA-binding transcription factor activity
KFV43_RS02925	COG0698	ribose 5-phosphate isomerase
KFV43_RS02930	COG0698	ribose 5-phosphate isomerase
KFV43_RS02935	COG1105	Belongs to the carbohydrate kinase PfkB family
KFV43_RS02940	COG3684	Belongs to the aldolase LacD family
KFV43_RS02945	COG1447	Phosphotransferase system cellobiose-specific component IIA
KFV43_RS02950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KFV43_RS02950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KFV43_RS02955	COG2723	6-phospho-beta-galactosidase activity
KFV43_RS02965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV43_RS02970	COG2130	NADP-dependent
KFV43_RS02975	COG0604	alcohol dehydrogenase
KFV43_RS02990	COG1302	Protein conserved in bacteria
KFV43_RS02995	COG4264	IucA IucC family
KFV43_RS03000	COG2814	Major facilitator Superfamily
KFV43_RS03005	COG4264	IucA IucC family
KFV43_RS03010	COG3457	Alanine racemase
KFV43_RS03015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KFV43_RS03020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV43_RS03025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV43_RS03030	COG3314	Sporulation integral membrane protein YlbJ
KFV43_RS03035	COG2329	Antibiotic biosynthesis monooxygenase
KFV43_RS03045	COG1988	membrane-bound metal-dependent
KFV43_RS03050	COG4284	Utp--glucose-1-phosphate uridylyltransferase
KFV43_RS03070	COG2814	Major facilitator Superfamily
KFV43_RS03075	COG0489	protein tyrosine kinase activity
KFV43_RS03125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KFV43_RS03135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFV43_RS03140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFV43_RS03145	COG0561	phosphatase activity
KFV43_RS03165	COG0640	Transcriptional regulator
KFV43_RS03170	COG0702	epimerase
KFV43_RS03175	COG1482	cell wall glycoprotein biosynthetic process
KFV43_RS03195	COG0783	Belongs to the Dps family
KFV43_RS03200	COG0813	purine-nucleoside phosphorylase activity
KFV43_RS03205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFV43_RS03210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KFV43_RS03215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KFV43_RS03225	COG1854	S-ribosylhomocysteine lyase activity
KFV43_RS03245	COG5146	pantothenate kinase activity
KFV43_RS03255	COG3343	RNA polymerase activity
KFV43_RS03260	COG0504	CTP synthase activity
KFV43_RS03270	COG0191	fructose-bisphosphate aldolase activity
KFV43_RS03275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFV43_RS03280	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS03285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KFV43_RS03290	COG0254	rRNA binding
KFV43_RS03295	COG1435	thymidine kinase activity
KFV43_RS03300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFV43_RS03305	COG2890	protein-(glutamine-N5) methyltransferase activity
KFV43_RS03310	COG0009	L-threonylcarbamoyladenylate synthase
KFV43_RS03315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV43_RS03320	COG4475	Protein of unknown function (DUF436)
KFV43_RS03325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFV43_RS03330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFV43_RS03335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KFV43_RS03345	COG0356	it plays a direct role in the translocation of protons across the membrane
KFV43_RS03355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFV43_RS03360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFV43_RS03365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFV43_RS03370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFV43_RS03375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFV43_RS03380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KFV43_RS03390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFV43_RS03395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFV43_RS03405	COG0629	single-stranded DNA binding
KFV43_RS03410	COG1388	LysM domain
KFV43_RS03415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KFV43_RS03425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KFV43_RS03430	COG0352	thiamine-phosphate diphosphorylase activity
KFV43_RS03435	COG0706	membrane insertase activity
KFV43_RS03440	COG1418	mRNA catabolic process
KFV43_RS03445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFV43_RS03450	COG1937	Protein conserved in bacteria
KFV43_RS03465	COG0772	Belongs to the SEDS family
KFV43_RS03470	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFV43_RS03475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFV43_RS03480	COG0513	Belongs to the DEAD box helicase family
KFV43_RS03490	COG3428	Bacterial PH domain
KFV43_RS03495	COG3402	PFAM membrane-flanked domain
KFV43_RS03500	COG0736	holo-[acyl-carrier-protein] synthase activity
KFV43_RS03505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFV43_RS03515	COG2337	Toxic component of a toxin-antitoxin (TA) module
KFV43_RS03520	COG2208	phosphoserine phosphatase activity
KFV43_RS03535	COG1191	sigma factor activity
KFV43_RS03540	COG2183	response to ionizing radiation
KFV43_RS03545	COG3091	SprT-like family
KFV43_RS03575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFV43_RS03580	COG0066	3-isopropylmalate dehydratase activity
KFV43_RS03585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFV43_RS03590	COG0473	3-isopropylmalate dehydrogenase activity
KFV43_RS03595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFV43_RS03600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFV43_RS03610	COG0028	Belongs to the TPP enzyme family
KFV43_RS03615	COG0129	dihydroxy-acid dehydratase activity
KFV43_RS03620	COG0802	atpase or kinase
KFV43_RS03625	COG1214	PFAM Peptidase M22, glycoprotease
KFV43_RS03630	COG0456	acetyltransferase
KFV43_RS03635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFV43_RS03640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFV43_RS03645	COG0488	(ABC) transporter
KFV43_RS03650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KFV43_RS03690	COG1388	LysM domain
KFV43_RS03690	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFV43_RS03730	COG2433	Pfam Transposase IS66
KFV43_RS03745	COG0582	viral genome integration into host DNA
KFV43_RS03815	COG4373	Mu-like prophage FluMu protein gp28
KFV43_RS03845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV43_RS03855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV43_RS03965	COG2887	Belongs to the helicase family. UvrD subfamily
KFV43_RS04015	COG0456	acetyltransferase
KFV43_RS04150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFV43_RS04195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFV43_RS04225	COG0587	DNA-directed DNA polymerase activity
KFV43_RS04230	COG0587	DNA-directed DNA polymerase activity
KFV43_RS04295	COG2226	methyltransferase
KFV43_RS04300	COG0270	DNA (cytosine-5-)-methyltransferase activity
KFV43_RS04340	COG1780	Probably involved in ribonucleotide reductase function
KFV43_RS04365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV43_RS04405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFV43_RS04415	COG0425	Belongs to the sulfur carrier protein TusA family
KFV43_RS04420	COG0004	ammonium transporteR
KFV43_RS04425	COG1609	Transcriptional regulator
KFV43_RS04430	COG1621	beta-fructofuranosidase activity
KFV43_RS04435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFV43_RS04440	COG3279	Response regulator of the LytR AlgR family
KFV43_RS04480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFV43_RS04485	COG0459	protein refolding
KFV43_RS04490	COG0582	viral genome integration into host DNA
KFV43_RS04505	COG3617	BRO family, N-terminal domain
KFV43_RS04625	COG1725	Transcriptional regulator
KFV43_RS04630	COG1131	(ABC) transporter
KFV43_RS04640	COG1131	(ABC) transporter
KFV43_RS04690	COG4974	Belongs to the 'phage' integrase family
KFV43_RS04720	COG3682	Transcriptional regulator
KFV43_RS04730	COG2706	6-phosphogluconolactonase activity
KFV43_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS04740	COG1227	inorganic diphosphatase activity
KFV43_RS04745	COG1335	isochorismatase
KFV43_RS04755	COG0077	Prephenate dehydratase
KFV43_RS04765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KFV43_RS04770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFV43_RS04775	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KFV43_RS04785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KFV43_RS04790	COG4496	protein, YerC YecD
KFV43_RS04795	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KFV43_RS04800	COG0210	DNA helicase
KFV43_RS04805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFV43_RS04810	COG4851	CamS sex pheromone cAM373 precursor
KFV43_RS04815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFV43_RS04820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFV43_RS04825	COG0154	amidase activity
KFV43_RS04830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFV43_RS04835	COG1597	lipid kinase activity
KFV43_RS04840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFV43_RS04850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFV43_RS04860	COG1528	Iron-storage protein
KFV43_RS04880	COG4129	membrane
KFV43_RS04885	COG0024	Methionine aminopeptidase
KFV43_RS04900	COG4585	Histidine kinase
KFV43_RS04905	COG2197	response regulator
KFV43_RS04910	COG1295	ribonuclease BN
KFV43_RS04920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV43_RS04925	COG4840	Belongs to the UPF0435 family
KFV43_RS04930	COG2309	aminopeptidase activity
KFV43_RS04935	COG1607	acyl-coa hydrolase
KFV43_RS04940	COG0535	radical SAM domain protein
KFV43_RS04950	COG0693	protein deglycase activity
KFV43_RS04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFV43_RS04960	COG2137	regulation of response to DNA damage stimulus
KFV43_RS04970	COG1134	teichoic acid transport
KFV43_RS04970	COG1388	LysM domain
KFV43_RS04980	COG1988	membrane-bound metal-dependent
KFV43_RS04995	COG3557	Belongs to the UPF0374 family
KFV43_RS05005	COG4129	membrane
KFV43_RS05010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFV43_RS05015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFV43_RS05020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV43_RS05025	COG0735	belongs to the Fur family
KFV43_RS05295	COG1595	DNA-templated transcription, initiation
KFV43_RS05395	COG4824	toxin secretion phage lysis holin
KFV43_RS05425	COG0765	amino acid transport
KFV43_RS05430	COG1126	abc transporter atp-binding protein
KFV43_RS05440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFV43_RS05465	COG0114	fumarate hydratase activity
KFV43_RS05475	COG4585	Histidine kinase
KFV43_RS05475	COG2203	Gaf domain
KFV43_RS05480	COG2197	response regulator
KFV43_RS05490	COG4399	Belongs to the UPF0754 family
KFV43_RS05495	COG3679	Belongs to the UPF0342 family
KFV43_RS05500	COG0420	3'-5' exonuclease activity
KFV43_RS05510	COG3481	metal-dependent phosphohydrolase, HD sub domain
KFV43_RS05520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFV43_RS05535	COG0537	adenosine 5'-monophosphoramidase activity
KFV43_RS05540	COG1131	(ABC) transporter
KFV43_RS05545	COG4473	ABC transporter
KFV43_RS05555	COG2329	Antibiotic biosynthesis monooxygenase
KFV43_RS05560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFV43_RS05565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFV43_RS05570	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KFV43_RS05730	COG3942	CHAP domain
KFV43_RS05835	COG0318	PFAM AMP-dependent synthetase and ligase
KFV43_RS05845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFV43_RS05850	COG0494	nUDIX hydrolase
KFV43_RS05855	COG1506	peptidase
KFV43_RS05860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFV43_RS05865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFV43_RS05875	COG0656	L-ascorbic acid biosynthetic process
KFV43_RS05890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFV43_RS05895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFV43_RS05905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFV43_RS05930	COG3266	domain, Protein
KFV43_RS05930	COG4193	domain, Protein
KFV43_RS05930	COG5632	N-Acetylmuramoyl-L-alanine amidase
KFV43_RS05940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFV43_RS05940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFV43_RS05950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFV43_RS05950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFV43_RS05955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KFV43_RS05960	COG0506	proline dehydrogenase activity
KFV43_RS05965	COG2267	carboxylic ester hydrolase activity
KFV43_RS05980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KFV43_RS05985	COG1242	4 iron, 4 sulfur cluster binding
KFV43_RS05990	COG2814	Major facilitator Superfamily
KFV43_RS05995	COG0495	leucyl-tRNA aminoacylation
KFV43_RS06010	COG2081	HI0933 family
KFV43_RS06015	COG2244	polysaccharide biosynthetic process
KFV43_RS06020	COG1187	pseudouridine synthase activity
KFV43_RS06030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV43_RS06035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFV43_RS06040	COG0510	thiamine kinase activity
KFV43_RS06045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFV43_RS06055	COG1363	Peptidase, m42
KFV43_RS06060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFV43_RS06065	COG4848	Belongs to the UPF0354 family
KFV43_RS06070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV43_RS06075	COG1674	ftsk spoiiie
KFV43_RS06080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFV43_RS06085	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KFV43_RS06095	COG1605	Chorismate mutase
KFV43_RS06095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KFV43_RS06100	COG1609	Transcriptional regulator
KFV43_RS06105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KFV43_RS06115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFV43_RS06120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFV43_RS06125	COG0204	Acyl-transferase
KFV43_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV43_RS06130	COG1263	PTS System
KFV43_RS06140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFV43_RS06145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFV43_RS06150	COG1764	response to oxidative stress
KFV43_RS06155	COG0584	glycerophosphoryl diester phosphodiesterase
KFV43_RS06160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFV43_RS06165	COG1956	GAF domain-containing protein
KFV43_RS06170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KFV43_RS06180	COG0301	tRNA thio-modification
KFV43_RS06190	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KFV43_RS06195	COG0827	DNA restriction-modification system
KFV43_RS06200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KFV43_RS06205	COG0589	response to stress
KFV43_RS06210	COG0686	Belongs to the AlaDH PNT family
KFV43_RS06215	COG0006	proline dipeptidase activity
KFV43_RS06220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFV43_RS06230	COG4109	DRTGG domain
KFV43_RS06235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KFV43_RS06240	COG0587	DNA-directed DNA polymerase activity
KFV43_RS06245	COG0281	malic enzyme
KFV43_RS06250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFV43_RS06255	COG0825	malonyl-CoA metabolic process
KFV43_RS06260	COG0205	6-phosphofructokinase activity
KFV43_RS06265	COG0469	pyruvate kinase activity
KFV43_RS06270	COG1113	amino acid transport
KFV43_RS06275	COG0372	Belongs to the citrate synthase family
KFV43_RS06280	COG0538	isocitrate dehydrogenase activity
KFV43_RS06285	COG0745	RESPONSE REGULATOR receiver
KFV43_RS06290	COG5002	protein histidine kinase activity
KFV43_RS06295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV43_RS06295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV43_RS06300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFV43_RS06305	COG0237	dephospho-CoA kinase activity
KFV43_RS06315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFV43_RS06320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFV43_RS06325	COG3611	Membrane attachment protein
KFV43_RS06330	COG1484	DNA-dependent DNA replication
KFV43_RS06335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFV43_RS06340	COG0833	amino acid
KFV43_RS06345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFV43_RS06350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFV43_RS06355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFV43_RS06360	COG4112	unkown
KFV43_RS06370	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFV43_RS06375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFV43_RS06380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFV43_RS06385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFV43_RS06395	COG0181	hydroxymethylbilane synthase activity
KFV43_RS06405	COG0113	porphobilinogen synthase activity
KFV43_RS06410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFV43_RS06420	COG2818	Glycosylase
KFV43_RS06425	COG0525	valine-tRNA ligase activity
KFV43_RS06430	COG0285	dihydrofolate synthase activity
KFV43_RS06440	COG2003	Belongs to the UPF0758 family
KFV43_RS06460	COG1792	Involved in formation and maintenance of cell shape
KFV43_RS06470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFV43_RS06475	COG2868	ribosomal protein
KFV43_RS06480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFV43_RS06490	COG4492	Belongs to the UPF0735 family
KFV43_RS06495	COG0632	four-way junction helicase activity
KFV43_RS06500	COG2255	four-way junction helicase activity
KFV43_RS06505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFV43_RS06510	COG0343	queuine tRNA-ribosyltransferase activity
KFV43_RS06515	COG1862	Preprotein translocase
KFV43_RS06520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFV43_RS06520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFV43_RS06525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KFV43_RS06525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFV43_RS06530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV43_RS06535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFV43_RS06540	COG1490	D-aminoacyl-tRNA deacylase activity
KFV43_RS06545	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFV43_RS06550	COG0124	histidyl-tRNA synthetase
KFV43_RS06555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFV43_RS06565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KFV43_RS06570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFV43_RS06575	COG1959	2 iron, 2 sulfur cluster binding
KFV43_RS06585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV43_RS06590	COG1104	cysteine desulfurase activity
KFV43_RS06595	COG0482	sulfurtransferase activity
KFV43_RS06605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV43_RS06610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFV43_RS06615	COG4472	Bacterial protein of unknown function (DUF965)
KFV43_RS06620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFV43_RS06625	COG3906	Belongs to the UPF0473 family
KFV43_RS06635	COG0826	peptidase U32
KFV43_RS06640	COG0826	peptidase U32
KFV43_RS06645	COG0572	uridine kinase
KFV43_RS06650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFV43_RS06660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KFV43_RS06665	COG1984	allophanate hydrolase subunit 2
KFV43_RS06670	COG0511	ligase activity, forming carbon-carbon bonds
KFV43_RS06675	COG0439	Biotin carboxylase
KFV43_RS06680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KFV43_RS06685	COG1914	H( )-stimulated, divalent metal cation uptake system
KFV43_RS06690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KFV43_RS06695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KFV43_RS06700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KFV43_RS06705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFV43_RS06710	COG1534	Rna-binding protein
KFV43_RS06715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFV43_RS06720	COG1713	HD superfamily hydrolase involved in NAD metabolism
KFV43_RS06725	COG0799	negative regulation of ribosome biogenesis
KFV43_RS06730	COG2226	methyltransferase
KFV43_RS06740	COG2131	deaminase
KFV43_RS06745	COG2333	competence protein COMEC
KFV43_RS06745	COG0658	competence protein
KFV43_RS06750	COG1466	dna polymerase III delta subunit
KFV43_RS06755	COG0268	Binds directly to 16S ribosomal RNA
KFV43_RS06760	COG0481	GTPase activity
KFV43_RS06765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFV43_RS06770	COG1420	regulation of RNA biosynthetic process
KFV43_RS06775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFV43_RS06780	COG0443	Heat shock 70 kDa protein
KFV43_RS06785	COG0484	heat shock protein binding
KFV43_RS06790	COG2264	protein methyltransferase activity
KFV43_RS06795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFV43_RS06800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFV43_RS06810	COG1030	water channel activity
KFV43_RS06815	COG4864	UPF0365 protein
KFV43_RS06825	COG1702	phosphate starvation-inducible protein PhoH
KFV43_RS06830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFV43_RS06835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KFV43_RS06840	COG0295	cytidine deaminase activity
KFV43_RS06845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFV43_RS06850	COG1381	Involved in DNA repair and RecF pathway recombination
KFV43_RS06855	COG0423	glycine-tRNA ligase activity
KFV43_RS06860	COG0517	IMP dehydrogenase activity
KFV43_RS06865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFV43_RS06870	COG0358	DNA primase activity
KFV43_RS06875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFV43_RS06880	COG2384	SAM-dependent methyltransferase
KFV43_RS06885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFV43_RS06890	COG0513	Belongs to the DEAD box helicase family
KFV43_RS06895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KFV43_RS06900	COG1121	(ABC) transporter
KFV43_RS06905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFV43_RS06910	COG0735	belongs to the Fur family
KFV43_RS06915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFV43_RS06920	COG0768	penicillin binding
KFV43_RS06925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFV43_RS06930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFV43_RS06940	COG4483	Protein conserved in bacteria
KFV43_RS06945	COG1940	carbohydrate kinase activity
KFV43_RS06950	COG0011	TIGRFAM Protein of
KFV43_RS06960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFV43_RS06965	COG1459	type II secretion system
KFV43_RS06970	COG4537	Required for transformation and DNA binding
KFV43_RS06990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFV43_RS06995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KFV43_RS07000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFV43_RS07005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFV43_RS07015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFV43_RS07020	COG0095	Lipoate-protein ligase
KFV43_RS07035	COG0006	proline dipeptidase activity
KFV43_RS07040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFV43_RS07045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFV43_RS07050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KFV43_RS07055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFV43_RS07060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFV43_RS07065	COG0511	ligase activity, forming carbon-carbon bonds
KFV43_RS07070	COG0439	Biotin carboxylase
KFV43_RS07075	COG1302	Protein conserved in bacteria
KFV43_RS07080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFV43_RS07085	COG1570	exodeoxyribonuclease VII activity
KFV43_RS07090	COG1722	exodeoxyribonuclease VII activity
KFV43_RS07100	COG1438	arginine binding
KFV43_RS07105	COG0497	DNA recombination
KFV43_RS07110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV43_RS07115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV43_RS07120	COG0022	dehydrogenase e1 component
KFV43_RS07125	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV43_RS07135	COG4129	membrane
KFV43_RS07145	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFV43_RS07150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KFV43_RS07155	COG0366	Alpha amylase catalytic
KFV43_RS07165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KFV43_RS07170	COG1234	tRNA 3'-trailer cleavage
KFV43_RS07175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KFV43_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS07185	COG0667	Aldo Keto reductase
KFV43_RS07190	COG0494	nUDIX hydrolase
KFV43_RS07195	COG0735	belongs to the Fur family
KFV43_RS07200	COG4974	Belongs to the 'phage' integrase family
KFV43_RS07205	COG1547	Domain of unknown function (DUF309)
KFV43_RS07210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KFV43_RS07215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFV43_RS07220	COG1187	pseudouridine synthase activity
KFV43_RS07225	COG0745	RESPONSE REGULATOR receiver
KFV43_RS07240	COG1141	Ferredoxin
KFV43_RS07250	COG0514	ATP-dependent DNA helicase (RecQ)
KFV43_RS07255	COG1388	LysM domain
KFV43_RS07260	COG0492	ferredoxin-NADP+ reductase activity
KFV43_RS07265	COG0252	asparaginase activity
KFV43_RS07270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFV43_RS07275	COG0539	negative regulation of cytoplasmic translation
KFV43_RS07280	COG1160	GTP binding
KFV43_RS07285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFV43_RS07300	COG2226	methyltransferase
KFV43_RS07310	COG0105	UTP biosynthetic process
KFV43_RS07315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFV43_RS07320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFV43_RS07325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFV43_RS07335	COG5582	Belongs to the UPF0302 family
KFV43_RS07340	COG4347	Protein of unknown function (DUF1405)
KFV43_RS07345	COG2738	Putative neutral zinc metallopeptidase
KFV43_RS07350	COG1694	Mazg nucleotide pyrophosphohydrolase
KFV43_RS07355	COG0438	transferase activity, transferring glycosyl groups
KFV43_RS07360	COG0617	tRNA 3'-terminal CCA addition
KFV43_RS07365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KFV43_RS07365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KFV43_RS07370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFV43_RS07370	COG1199	ATP-dependent helicase activity
KFV43_RS07375	COG0017	Asparaginyl-tRNA synthetase
KFV43_RS07380	COG3935	DnaD domain protein
KFV43_RS07385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFV43_RS07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFV43_RS07395	COG4499	WXG100 protein secretion system (Wss), protein YukC
KFV43_RS07400	COG3331	DNA recombination
KFV43_RS07410	COG4474	Belongs to the UPF0398 family
KFV43_RS07415	COG3599	regulation of cell shape
KFV43_RS07425	COG0116	Belongs to the methyltransferase superfamily
KFV43_RS07435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KFV43_RS07440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV43_RS07455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KFV43_RS07465	COG1413	lyase activity
KFV43_RS07480	COG1136	(ABC) transporter
KFV43_RS07505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFV43_RS07510	COG2190	(PTS) system
KFV43_RS07515	COG4479	Belongs to the UPF0346 family
KFV43_RS07520	COG0793	Belongs to the peptidase S41A family
KFV43_RS07530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFV43_RS07535	COG0671	phosphoesterase, PA-phosphatase related
KFV43_RS07540	COG3842	ATPase activity
KFV43_RS07545	COG4209	transmembrane transport
KFV43_RS07555	COG0395	ABC-type sugar transport system, permease component
KFV43_RS07565	COG0534	Mate efflux family protein
KFV43_RS07570	COG1349	DNA-binding transcription factor activity
KFV43_RS07575	COG0745	RESPONSE REGULATOR receiver
KFV43_RS07580	COG5002	protein histidine kinase activity
KFV43_RS07585	COG0567	Dehydrogenase, E1 component
KFV43_RS07590	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV43_RS07615	COG0714	Associated with various cellular activities
KFV43_RS07620	COG4548	von Willebrand factor, type A
KFV43_RS07625	COG1114	Component of the transport system for branched-chain amino acids
KFV43_RS07630	COG3853	Toxic anion resistance protein (TelA)
KFV43_RS07640	COG1254	Belongs to the acylphosphatase family
KFV43_RS07650	COG1278	Cold shock
KFV43_RS07665	COG1131	(ABC) transporter
KFV43_RS07685	COG1473	amidohydrolase
KFV43_RS07690	COG2171	N-acyltransferase activity
KFV43_RS07695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFV43_RS07700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFV43_RS07705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFV43_RS07710	COG0527	aspartate kinase activity
KFV43_RS07715	COG0488	(ABC) transporter
KFV43_RS07720	COG2996	Protein conserved in bacteria
KFV43_RS07725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KFV43_RS07730	COG0573	inorganic phosphate transmembrane transporter activity
KFV43_RS07735	COG0581	inorganic phosphate transmembrane transporter activity
KFV43_RS07740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFV43_RS07745	COG0704	Plays a role in the regulation of phosphate uptake
KFV43_RS07780	COG4607	ABC-type enterochelin transport system periplasmic component
KFV43_RS07790	COG2348	transferase activity, transferring amino-acyl groups
KFV43_RS07795	COG2348	transferase activity, transferring amino-acyl groups
KFV43_RS07805	COG0159	tryptophan synthase activity
KFV43_RS07810	COG0133	tryptophan synthase activity
KFV43_RS07815	COG0135	phosphoribosylanthranilate isomerase activity
KFV43_RS07820	COG0134	indole-3-glycerol-phosphate synthase activity
KFV43_RS07825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFV43_RS07830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFV43_RS07830	COG0512	Glutamine amidotransferase of anthranilate synthase
KFV43_RS07835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFV43_RS07840	COG0287	Prephenate dehydrogenase
KFV43_RS07845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFV43_RS07850	COG1942	4-Oxalocrotonate Tautomerase
KFV43_RS07865	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KFV43_RS07865	COG0392	lysyltransferase activity
KFV43_RS07870	COG0628	permease
KFV43_RS07875	COG3711	transcriptional antiterminator
KFV43_RS07880	COG1115	amino acid carrier protein
KFV43_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFV43_RS07890	COG0187	DNA topoisomerase II activity
KFV43_RS07895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KFV43_RS07900	COG4841	protein insertion into membrane
KFV43_RS07910	COG0824	Thioesterase
KFV43_RS07915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KFV43_RS07920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFV43_RS07925	COG1970	mechanosensitive ion channel activity
KFV43_RS07930	COG0419	ATPase involved in DNA repair
KFV43_RS07935	COG0420	3'-5' exonuclease activity
KFV43_RS07940	COG4846	Membrane protein involved in cytochrome C biogenesis
KFV43_RS07950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KFV43_RS07955	COG4224	UPF0291 protein
KFV43_RS07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFV43_RS07970	COG2340	Cysteine-rich secretory protein family
KFV43_RS07975	COG0516	GMP reductase activity
KFV43_RS07980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFV43_RS07990	COG0753	catalase activity
KFV43_RS07995	COG0833	amino acid
KFV43_RS08010	COG0083	homoserine kinase activity
KFV43_RS08015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KFV43_RS08020	COG0460	homoserine dehydrogenase
KFV43_RS08025	COG0527	aspartate kinase activity
KFV43_RS08045	COG1525	nuclease
KFV43_RS08055	COG2197	response regulator
KFV43_RS08060	COG4585	Histidine kinase
KFV43_RS08070	COG1131	(ABC) transporter
KFV43_RS08075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFV43_RS08135	COG4824	toxin secretion phage lysis holin
KFV43_RS08255	COG1595	DNA-templated transcription, initiation
KFV43_RS08280	COG0629	single-stranded DNA binding
KFV43_RS08340	COG0174	glutamine synthetase
KFV43_RS08345	COG0789	Transcriptional regulator
KFV43_RS08350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KFV43_RS08355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFV43_RS08360	COG0386	Belongs to the glutathione peroxidase family
KFV43_RS08365	COG1923	regulation of RNA biosynthetic process
KFV43_RS08370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFV43_RS08380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KFV43_RS08385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KFV43_RS08390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KFV43_RS08395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KFV43_RS08400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFV43_RS08405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFV43_RS08415	COG4550	Control of competence regulator ComK, YlbF/YmcA
KFV43_RS08420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFV43_RS08430	COG4195	phage-related replication protein
KFV43_RS08435	COG1013	pyruvate-flavodoxin oxidoreductase activity
KFV43_RS08440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFV43_RS08440	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFV43_RS08445	COG1692	metallophosphoesterase
KFV43_RS08455	COG1418	mRNA catabolic process
KFV43_RS08460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFV43_RS08470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFV43_RS08485	COG0300	oxidoreductase activity
KFV43_RS08490	COG0612	Peptidase, M16
KFV43_RS08495	COG0612	Peptidase, M16
KFV43_RS08500	COG2188	Transcriptional regulator
KFV43_RS08505	COG1674	ftsk spoiiie
KFV43_RS08510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFV43_RS08515	COG1185	polyribonucleotide nucleotidyltransferase activity
KFV43_RS08520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFV43_RS08525	COG0196	riboflavin kinase activity
KFV43_RS08530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFV43_RS08535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFV43_RS08540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFV43_RS08545	COG1358	cellular component organization or biogenesis
KFV43_RS08550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KFV43_RS08555	COG0195	Participates in both transcription termination and antitermination
KFV43_RS08560	COG0779	Required for maturation of 30S ribosomal subunits
KFV43_RS08565	COG2176	DNA-directed DNA polymerase activity
KFV43_RS08570	COG0442	prolyl-tRNA aminoacylation
KFV43_RS08580	COG4589	Belongs to the CDS family
KFV43_RS08585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFV43_RS08590	COG0233	cytoplasmic translational termination
KFV43_RS08595	COG0528	UMP kinase activity
KFV43_RS08600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFV43_RS08605	COG0052	Belongs to the universal ribosomal protein uS2 family
KFV43_RS08610	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KFV43_RS08615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KFV43_RS08620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KFV43_RS08625	COG4974	Belongs to the 'phage' integrase family
KFV43_RS08630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KFV43_RS08635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFV43_RS08640	COG0758	DNA mediated transformation
KFV43_RS08645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KFV43_RS08650	COG0045	succinate-CoA ligase (ADP-forming) activity
KFV43_RS08655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFV43_RS08670	COG4485	Bacterial membrane protein, YfhO
KFV43_RS08680	COG0335	large ribosomal subunit rRNA binding
KFV43_RS08685	COG0336	Belongs to the RNA methyltransferase TrmD family
KFV43_RS08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFV43_RS08695	COG0228	four-way junction DNA binding
KFV43_RS08700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFV43_RS08705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KFV43_RS08710	COG0552	protein localization to endoplasmic reticulum
KFV43_RS08715	COG1196	nuclear chromosome segregation
KFV43_RS08720	COG0571	ribonuclease III activity
KFV43_RS08725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFV43_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS08740	COG0416	fatty acid biosynthetic process
KFV43_RS08745	COG1349	DNA-binding transcription factor activity
KFV43_RS08750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFV43_RS08755	COG1461	Dihydroxyacetone kinase
KFV43_RS08760	COG1302	Protein conserved in bacteria
KFV43_RS08765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFV43_RS08775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFV43_RS08780	COG1162	GTPase activity
KFV43_RS08790	COG0631	protein serine/threonine phosphatase activity
KFV43_RS08795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFV43_RS08800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFV43_RS08800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFV43_RS08805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFV43_RS08810	COG0242	peptide deformylase activity
KFV43_RS08820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFV43_RS08825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFV43_RS08830	COG1758	RNA polymerase activity
KFV43_RS08835	COG0194	GDP metabolic process
KFV43_RS08855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFV43_RS08860	COG0284	orotidine-5'-phosphate decarboxylase activity
KFV43_RS08865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFV43_RS08870	COG0505	Belongs to the CarA family
KFV43_RS08875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFV43_RS08880	COG0540	Belongs to the ATCase OTCase family
KFV43_RS08885	COG2233	PERMEase
KFV43_RS08890	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KFV43_RS08895	COG0564	pseudouridine synthase activity
KFV43_RS08900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFV43_RS08905	COG1388	LysM domain
KFV43_RS08905	COG3942	CHAP domain
KFV43_RS08915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFV43_RS08920	COG3599	regulation of cell shape
KFV43_RS08930	COG0762	integral membrane protein
KFV43_RS08935	COG1799	cell septum assembly
KFV43_RS08940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFV43_RS08945	COG1496	oxidoreductase activity
KFV43_RS08950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFV43_RS08955	COG0849	cell division
KFV43_RS08960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KFV43_RS08965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFV43_RS08970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFV43_RS08975	COG0768	penicillin binding
KFV43_RS08980	COG4839	cell division protein FtsL
KFV43_RS08985	COG0275	rRNA processing
KFV43_RS08990	COG2001	Belongs to the MraZ family
KFV43_RS08995	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KFV43_RS09000	COG0454	-acetyltransferase
KFV43_RS09005	COG1011	Hydrolase
KFV43_RS09035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFV43_RS09040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFV43_RS09045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFV43_RS09050	COG1053	succinate dehydrogenase
KFV43_RS09055	COG2009	succinate dehydrogenase
KFV43_RS09060	COG0322	excinuclease ABC activity
KFV43_RS09065	COG3118	belongs to the thioredoxin family
KFV43_RS09070	COG1193	negative regulation of DNA recombination
KFV43_RS09075	COG1796	DNA polymerase
KFV43_RS09075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KFV43_RS09085	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KFV43_RS09090	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFV43_RS09095	COG0072	phenylalanine-tRNA ligase activity
KFV43_RS09095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV43_RS09100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFV43_RS09105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFV43_RS09115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFV43_RS09125	COG1323	Belongs to the UPF0348 family
KFV43_RS09130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFV43_RS09135	COG0742	ribosomal rna small subunit methyltransferase
KFV43_RS09145	COG4471	UPF0298 protein
KFV43_RS09150	COG0584	glycerophosphoryl diester phosphodiesterase
KFV43_RS09155	COG3679	Belongs to the UPF0342 family
KFV43_RS09160	COG2340	Cysteine-rich secretory protein family
KFV43_RS09170	COG0109	protoheme IX farnesyltransferase activity
KFV43_RS09175	COG1612	heme a metabolic process
KFV43_RS09185	COG0772	Belongs to the SEDS family
KFV43_RS09190	COG4838	Belongs to the UPF0358 family
KFV43_RS09195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFV43_RS09200	COG4896	Protein conserved in bacteria
KFV43_RS09215	COG1217	gtp-binding protein TYPA
KFV43_RS09225	COG0483	inositol monophosphate 1-phosphatase activity
KFV43_RS09230	COG4493	Belongs to the UPF0637 family
KFV43_RS09235	COG1914	H( )-stimulated, divalent metal cation uptake system
KFV43_RS09260	COG1176	ABC-type spermidine putrescine transport system, permease component I
KFV43_RS09265	COG3842	ATPase activity
KFV43_RS09275	COG4476	Belongs to the UPF0223 family
KFV43_RS09285	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV43_RS09290	COG0022	dehydrogenase e1 component
KFV43_RS09295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV43_RS09305	COG0242	peptide deformylase activity
KFV43_RS09310	COG5503	Protein of unknown function (DUF1447)
KFV43_RS09315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFV43_RS09320	COG0569	domain protein
KFV43_RS09325	COG1294	oxidase, subunit
KFV43_RS09330	COG1271	oxidase subunit
KFV43_RS09340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFV43_RS09345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV43_RS09370	COG4716	Myosin-crossreactive antigen
KFV43_RS09380	COG4172	Belongs to the ABC transporter superfamily
KFV43_RS09385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFV43_RS09390	COG0151	Belongs to the GarS family
KFV43_RS09395	COG0138	bifunctional purine biosynthesis protein purh
KFV43_RS09400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFV43_RS09405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KFV43_RS09410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KFV43_RS09415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFV43_RS09420	COG0047	phosphoribosylformylglycinamidine synthase activity
KFV43_RS09425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFV43_RS09430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFV43_RS09435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFV43_RS09440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFV43_RS09445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFV43_RS09455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFV43_RS09460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFV43_RS09465	COG1845	cytochrome c oxidase, subunit III
KFV43_RS09470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KFV43_RS09485	COG1316	TRANSCRIPTIONal
KFV43_RS09510	COG3594	Acyltransferase
KFV43_RS09515	COG0436	Aminotransferase
KFV43_RS09520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KFV43_RS09530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KFV43_RS09535	COG1169	isochorismate synthase
KFV43_RS09540	COG1575	Belongs to the MenA family. Type 1 subfamily
KFV43_RS09545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFV43_RS09550	COG2314	TM2 domain
KFV43_RS09610	COG4873	Protein conserved in bacteria
KFV43_RS09625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFV43_RS09630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFV43_RS09635	COG0861	Integral membrane protein TerC family
KFV43_RS09640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFV43_RS09650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFV43_RS09655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFV43_RS09660	COG2814	Major facilitator Superfamily
KFV43_RS09665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KFV43_RS09670	COG2382	esterase
KFV43_RS09675	COG0628	permease
KFV43_RS09735	COG0475	glutathione-regulated potassium exporter activity
KFV43_RS09735	COG0569	domain protein
KFV43_RS09740	COG2239	Acts as a magnesium transporter
KFV43_RS09745	COG0564	pseudouridine synthase activity
KFV43_RS09750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFV43_RS09755	COG2357	RelA SpoT domain protein
KFV43_RS09770	COG2346	COG2346, Truncated hemoglobins
KFV43_RS09775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFV43_RS09780	COG1164	Oligoendopeptidase f
KFV43_RS09790	COG4862	establishment of competence for transformation
KFV43_RS09800	COG1393	Belongs to the ArsC family
KFV43_RS09805	COG0180	Tryptophanyl-tRNA synthetase
KFV43_RS09810	COG4166	transmembrane transport
KFV43_RS09815	COG4608	Belongs to the ABC transporter superfamily
KFV43_RS09820	COG0444	Belongs to the ABC transporter superfamily
KFV43_RS09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFV43_RS09830	COG0601	transmembrane transport
KFV43_RS09845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFV43_RS09860	COG0542	response to heat
KFV43_RS09875	COG0561	phosphatase activity
KFV43_RS09880	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFV43_RS09900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFV43_RS09905	COG0746	molybdenum cofactor guanylyltransferase activity
KFV43_RS09915	COG0314	molybdopterin synthase activity
KFV43_RS09925	COG0303	'Molybdopterin
KFV43_RS09930	COG0315	cyclic pyranopterin monophosphate synthase activity
KFV43_RS09935	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFV43_RS09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFV43_RS09945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KFV43_RS09950	COG4149	molybdate abc transporter
KFV43_RS09955	COG0725	ABC transporter, periplasmic molybdate-binding protein
KFV43_RS09970	COG1268	BioY protein
KFV43_RS09980	COG1960	acyl-CoA dehydrogenase activity
KFV43_RS09990	COG0831	urea catabolic process
KFV43_RS09995	COG0832	Belongs to the urease beta subunit family
KFV43_RS10000	COG0804	urea catabolic process
KFV43_RS10005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KFV43_RS10010	COG0830	nickel cation binding
KFV43_RS10015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFV43_RS10020	COG0829	nickel cation binding
KFV43_RS10045	COG3942	CHAP domain
KFV43_RS10050	COG1757	Na H antiporter
KFV43_RS10065	COG3942	CHAP domain
KFV43_RS10070	COG2076	Multidrug Resistance protein
KFV43_RS10075	COG2076	Multidrug Resistance protein
KFV43_RS10080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV43_RS10100	COG1316	TRANSCRIPTIONal
KFV43_RS10105	COG0483	inositol monophosphate 1-phosphatase activity
KFV43_RS10110	COG2378	regulation of single-species biofilm formation
KFV43_RS10115	COG1266	CAAX protease self-immunity
KFV43_RS10130	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KFV43_RS10135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV43_RS10135	COG1263	PTS System
KFV43_RS10145	COG1113	amino acid transport
KFV43_RS10170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFV43_RS10180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV43_RS10180	COG1263	PTS System
KFV43_RS10185	COG1737	Transcriptional regulator
KFV43_RS10215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFV43_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS10225	COG1473	amidohydrolase
KFV43_RS10230	COG0010	Belongs to the arginase family
KFV43_RS10235	COG1266	CAAX protease self-immunity
KFV43_RS10245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFV43_RS10250	COG2258	MOSC domain
KFV43_RS10255	COG2017	converts alpha-aldose to the beta-anomer
KFV43_RS10260	COG1069	ribulokinase activity
KFV43_RS10270	COG2094	Belongs to the DNA glycosylase MPG family
KFV43_RS10290	COG0786	glutamate:sodium symporter activity
KFV43_RS10295	COG1304	FMN binding
KFV43_RS10300	COG0598	Magnesium transport protein CorA
KFV43_RS10315	COG0657	acetylesterase activity
KFV43_RS10325	COG2814	Major facilitator Superfamily
KFV43_RS10330	COG1566	PFAM secretion protein HlyD family protein
KFV43_RS10340	COG2814	Major facilitator Superfamily
KFV43_RS10345	COG4640	response to antibiotic
KFV43_RS10360	COG1136	(ABC) transporter
KFV43_RS10365	COG0577	efflux transmembrane transporter activity
KFV43_RS10370	COG0745	RESPONSE REGULATOR receiver
KFV43_RS10375	COG5002	protein histidine kinase activity
KFV43_RS10375	COG3850	Histidine kinase
KFV43_RS10380	COG0579	oxidoreductase
KFV43_RS10385	COG0438	transferase activity, transferring glycosyl groups
KFV43_RS10390	COG1620	l-lactate permease
KFV43_RS10395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS10395	COG0463	Glycosyl transferase, family 2
KFV43_RS10405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS10405	COG0463	Glycosyl transferase, family 2
KFV43_RS10410	COG0456	acetyltransferase
KFV43_RS10415	COG0604	alcohol dehydrogenase
KFV43_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV43_RS10450	COG1263	PTS System
KFV43_RS10465	COG3871	stress protein (general stress protein 26)
KFV43_RS10490	COG1846	Transcriptional regulator
KFV43_RS10495	COG2223	nitrite transmembrane transporter activity
KFV43_RS10500	COG2197	response regulator
KFV43_RS10505	COG4585	Histidine kinase
KFV43_RS10515	COG2181	nitrate reductase activity
KFV43_RS10525	COG1140	nitrate reductase beta subunit
KFV43_RS10530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KFV43_RS10540	COG2146	nitrite reductase [NAD(P)H] activity
KFV43_RS10545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFV43_RS10555	COG0747	negative chemotaxis
KFV43_RS10565	COG0454	-acetyltransferase
KFV43_RS10570	COG2116	formate transmembrane transporter activity
KFV43_RS10590	COG2348	transferase activity, transferring amino-acyl groups
KFV43_RS10600	COG1126	abc transporter atp-binding protein
KFV43_RS10605	COG0765	amino acid transport
KFV43_RS10610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFV43_RS10620	COG0588	phosphoglycerate mutase activity
KFV43_RS10625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KFV43_RS10640	COG1929	Belongs to the glycerate kinase type-1 family
KFV43_RS10665	COG1113	amino acid transport
KFV43_RS10670	COG0531	amino acid
KFV43_RS10680	COG0706	membrane insertase activity
KFV43_RS10685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFV43_RS10695	COG3275	phosphorelay sensor kinase activity
KFV43_RS10700	COG3279	Response regulator of the LytR AlgR family
KFV43_RS10705	COG1380	Effector of murein hydrolase LrgA
KFV43_RS10710	COG1346	cytolysis
KFV43_RS10715	COG1174	glycine betaine transport
KFV43_RS10735	COG1063	alcohol dehydrogenase
KFV43_RS10745	COG0531	amino acid
KFV43_RS10750	COG2272	Belongs to the type-B carboxylesterase lipase family
KFV43_RS10755	COG2814	Major facilitator Superfamily
KFV43_RS10760	COG0390	transport system, permease component
KFV43_RS10765	COG4619	ABC transporter
KFV43_RS10780	COG0069	glutamate synthase activity
KFV43_RS10790	COG1363	Peptidase, m42
KFV43_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS10805	COG0248	Ppx GppA phosphatase
KFV43_RS10810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFV43_RS10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV43_RS10820	COG4221	oxidoreductase activity
KFV43_RS10835	COG0556	nucleotide-excision repair
KFV43_RS10840	COG0494	nUDIX hydrolase
KFV43_RS10845	COG0438	transferase activity, transferring glycosyl groups
KFV43_RS10850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFV43_RS10855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KFV43_RS10860	COG2610	gluconate transmembrane transporter activity
KFV43_RS10870	COG1802	Transcriptional regulator
KFV43_RS10875	COG2271	Major facilitator Superfamily
KFV43_RS10880	COG0789	Transcriptional regulator
KFV43_RS10895	COG2357	RelA SpoT domain protein
KFV43_RS10900	COG4876	unkown
KFV43_RS10915	COG2271	Major facilitator Superfamily
KFV43_RS10925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFV43_RS10935	COG2022	thiamine diphosphate biosynthetic process
KFV43_RS10940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFV43_RS10945	COG0586	Pfam SNARE associated Golgi protein
KFV43_RS10950	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KFV43_RS10960	COG3949	Membrane
KFV43_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS10980	COG2514	catechol 2,3-dioxygenase activity
KFV43_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS10995	COG0778	Nitroreductase
KFV43_RS11000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV43_RS11010	COG3764	Sortase (surface protein transpeptidase)
KFV43_RS11035	COG1760	l-serine dehydratase
KFV43_RS11040	COG1760	l-serine dehydratase
KFV43_RS11055	COG1070	Carbohydrate kinase
KFV43_RS11065	COG1869	D-ribose catabolic process
KFV43_RS11070	COG4975	Glucose uptake
KFV43_RS11085	COG2843	Capsule synthesis protein
KFV43_RS11095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFV43_RS11110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFV43_RS11120	COG1063	alcohol dehydrogenase
KFV43_RS11135	COG1263	PTS System
KFV43_RS11135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV43_RS11135	COG2190	(PTS) system
KFV43_RS11140	COG0028	Belongs to the TPP enzyme family
KFV43_RS11145	COG1346	cytolysis
KFV43_RS11150	COG1380	Effector of murein hydrolase LrgA
KFV43_RS11155	COG0583	DNA-binding transcription factor activity
KFV43_RS11175	COG3425	synthase
KFV43_RS11180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFV43_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS11220	COG2217	Heavy metal translocating P-type atpase
KFV43_RS11225	COG2608	mercury ion transmembrane transporter activity
KFV43_RS11235	COG0436	Aminotransferase
KFV43_RS11240	COG3942	CHAP domain
KFV43_RS11250	COG0741	lytic transglycosylase activity
KFV43_RS11265	COG1113	amino acid transport
KFV43_RS11270	COG3001	Fructosamine kinase
KFV43_RS11275	COG0167	dihydroorotate dehydrogenase activity
KFV43_RS11290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFV43_RS11305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KFV43_RS11310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KFV43_RS11315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFV43_RS11325	COG3527	Alpha-acetolactate decarboxylase
KFV43_RS11330	COG0028	Belongs to the TPP enzyme family
KFV43_RS11335	COG0039	L-malate dehydrogenase activity
KFV43_RS11340	COG0583	DNA-binding transcription factor activity
KFV43_RS11345	COG0531	amino acid
KFV43_RS11375	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFV43_RS11380	COG3588	fructose-bisphosphate aldolase
KFV43_RS11390	COG0579	oxidoreductase
KFV43_RS11395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFV43_RS11400	COG0574	Belongs to the PEP-utilizing enzyme family
KFV43_RS11400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFV43_RS11405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFV43_RS11420	COG1473	amidohydrolase
KFV43_RS11425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KFV43_RS11430	COG1012	belongs to the aldehyde dehydrogenase family
KFV43_RS11435	COG1510	regulation of RNA biosynthetic process
KFV43_RS11445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KFV43_RS11450	COG0602	queuosine metabolic process
KFV43_RS11455	COG1328	CTP reductase activity
KFV43_RS11465	COG0529	Catalyzes the synthesis of activated sulfate
KFV43_RS11470	COG2046	Belongs to the sulfate adenylyltransferase family
KFV43_RS11475	COG0730	response to heat
KFV43_RS11490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFV43_RS11495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KFV43_RS11500	COG0175	sulfate reduction
KFV43_RS11505	COG0386	Belongs to the glutathione peroxidase family
KFV43_RS11515	COG1846	Transcriptional regulator
KFV43_RS11540	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFV43_RS11555	COG1136	(ABC) transporter
KFV43_RS11560	COG2205	protein histidine kinase activity
KFV43_RS11580	COG1785	Belongs to the alkaline phosphatase family
KFV43_RS11585	COG0702	epimerase
KFV43_RS11600	COG4195	phage-related replication protein
KFV43_RS11610	COG1196	nuclear chromosome segregation
KFV43_RS11635	COG3961	Belongs to the TPP enzyme family
KFV43_RS11640	COG2843	Capsule synthesis protein
KFV43_RS11650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFV43_RS11660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFV43_RS11665	COG2235	arginine
KFV43_RS11670	COG1438	arginine binding
KFV43_RS11675	COG3227	Zinc metalloprotease (Elastase)
KFV43_RS11680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV43_RS11715	COG3711	transcriptional antiterminator
KFV43_RS11715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV43_RS11720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV43_RS11720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV43_RS11720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV43_RS11725	COG1482	cell wall glycoprotein biosynthetic process
KFV43_RS11735	COG1705	Flagellar rod assembly protein muramidase FlgJ
KFV43_RS11735	COG3942	CHAP domain
KFV43_RS11745	COG1764	response to oxidative stress
KFV43_RS11760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFV43_RS11765	COG2814	Major facilitator Superfamily
KFV43_RS11790	COG0438	transferase activity, transferring glycosyl groups
KFV43_RS11795	COG0653	protein targeting
KFV43_RS11815	COG0201	protein transport
KFV43_RS11835	COG3639	organic phosphonate transmembrane transporter activity
KFV43_RS11840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KFV43_RS11855	COG0737	Belongs to the 5'-nucleotidase family
KFV43_RS11860	COG2814	Major facilitator Superfamily
KFV43_RS11885	COG0726	polysaccharide deacetylase
KFV43_RS11895	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KFV43_RS11900	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KFV43_RS11905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFV43_RS11905	COG0140	phosphoribosyl-ATP diphosphatase activity
KFV43_RS11910	COG0107	imidazoleglycerol-phosphate synthase activity
KFV43_RS11915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFV43_RS11920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFV43_RS11925	COG0131	Imidazoleglycerol-phosphate dehydratase
KFV43_RS11930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFV43_RS11935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KFV43_RS11940	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KFV43_RS11965	COG0579	oxidoreductase
KFV43_RS11970	COG2353	YceI-like domain
KFV43_RS11975	COG3386	PFAM SMP-30 Gluconolaconase
KFV43_RS11980	COG1054	Belongs to the UPF0176 family
KFV43_RS11985	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KFV43_RS12010	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV43_RS12015	COG0022	dehydrogenase e1 component
KFV43_RS12020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV43_RS12025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV43_RS12030	COG0471	metal ion transport
KFV43_RS12035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFV43_RS12040	COG2962	Rard protein
KFV43_RS12055	COG2814	Major facilitator Superfamily
KFV43_RS12085	COG2814	Major facilitator Superfamily
KFV43_RS12100	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KFV43_RS12105	COG1461	Dihydroxyacetone kinase
KFV43_RS12110	COG2376	Dihydroxyacetone kinase
KFV43_RS12120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFV43_RS12125	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KFV43_RS12140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFV43_RS12145	COG0549	Belongs to the carbamate kinase family
KFV43_RS12150	COG1288	antiporter activity
KFV43_RS12185	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFV43_RS12190	COG3246	L-lysine catabolic process to acetate
KFV43_RS12195	COG1309	transcriptional regulator
KFV43_RS12200	COG1114	Component of the transport system for branched-chain amino acids
KFV43_RS12205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV43_RS12210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KFV43_RS12215	COG1882	Formate acetyltransferase
KFV43_RS12225	COG1124	(ABC) transporter
KFV43_RS12230	COG0444	Belongs to the ABC transporter superfamily
KFV43_RS12240	COG0601	transmembrane transport
KFV43_RS12270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KFV43_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS12285	COG3976	FMN-binding domain protein
KFV43_RS12285	COG1053	succinate dehydrogenase
KFV43_RS12285	COG0431	NADPH-dependent FMN reductase
KFV43_RS12295	COG0803	Belongs to the bacterial solute-binding protein 9 family
KFV43_RS12310	COG0523	cobalamin synthesis protein
KFV43_RS12335	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
KFV43_RS12345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFV43_RS12350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFV43_RS12360	COG3583	domain protein
KFV43_RS12360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KFV43_RS12360	COG3583	domain protein
KFV43_RS12360	COG4932	domain protein
KFV43_RS12360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KFV43_RS12360	COG4932	domain protein
KFV43_RS12390	COG2207	Transcriptional regulator
KFV43_RS12390	COG4753	response regulator
KFV43_RS12400	COG1755	Isoprenylcysteine carboxyl methyltransferase
KFV43_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
KFV43_RS12415	COG0579	oxidoreductase
KFV43_RS12420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFV43_RS12450	COG0561	phosphatase activity
KFV43_RS12455	COG0668	transmembrane transport
KFV43_RS12475	COG0640	Transcriptional regulator
KFV43_RS12495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KFV43_RS12500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV43_RS12510	COG1388	LysM domain
KFV43_RS12515	COG2132	Multicopper oxidase
KFV43_RS12520	COG2217	Heavy metal translocating P-type atpase
KFV43_RS12545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV43_RS12550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV43_RS12620	COG0477	Major facilitator Superfamily
KFV43_RS12630	COG2070	2-Nitropropane dioxygenase
KFV43_RS12655	COG1396	sequence-specific DNA binding
KFV43_RS12715	COG2003	Belongs to the UPF0758 family
KFV43_RS12755	COG1937	Protein conserved in bacteria
KFV43_RS12760	COG2210	Belongs to the sulfur carrier protein TusA family
KFV43_RS12770	COG1846	Transcriptional regulator
KFV43_RS12770	COG1940	carbohydrate kinase activity
KFV43_RS12795	COG2030	dehydratase
KFV43_RS12800	COG0584	glycerophosphoryl diester phosphodiesterase
KFV43_RS12805	COG3425	synthase
KFV43_RS12820	COG1388	LysM domain
KFV43_RS12830	COG0730	response to heat
KFV43_RS12855	COG2003	Belongs to the UPF0758 family
KFV43_RS12890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV43_RS12890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV43_RS12910	COG2217	Heavy metal translocating P-type atpase
KFV43_RS12915	COG0640	Transcriptional regulator
KFV43_RS12940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFV43_RS12980	COG1215	transferase activity, transferring glycosyl groups
KFV43_RS12980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS12990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV43_RS13030	COG0076	glutamate decarboxylase activity
KFV43_RS13035	COG0745	RESPONSE REGULATOR receiver
KFV43_RS13040	COG1131	(ABC) transporter
KFV43_RS13050	COG2205	protein histidine kinase activity
KFV43_RS13060	COG2409	Drug exporters of the RND superfamily
KFV43_RS13065	COG2113	Glycine betaine
KFV43_RS13090	COG1396	sequence-specific DNA binding
KFV43_RS13095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFV43_RS13100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFV43_RS13110	COG4863	YycH protein
KFV43_RS13115	COG5002	protein histidine kinase activity
KFV43_RS13120	COG0745	RESPONSE REGULATOR receiver
KFV43_RS13135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFV43_RS13140	COG0305	Participates in initiation and elongation during chromosome replication
KFV43_RS13145	COG0359	binds to the 23S rRNA
KFV43_RS13150	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KFV43_RS13160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFV43_RS13180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFV43_RS13185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFV43_RS13190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFV43_RS13195	COG0187	DNA topoisomerase II activity
KFV43_RS13200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFV43_RS13205	COG2501	S4 domain
KFV43_RS13490	COG2314	TM2 domain