locus-tag	class	description
KFV48_RS00085	COG0592	DNA-directed DNA polymerase activity
KFV48_RS00090	COG2501	S4 domain
KFV48_RS00095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFV48_RS00100	COG0187	DNA topoisomerase II activity
KFV48_RS00105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFV48_RS00110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFV48_RS00115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFV48_RS00135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFV48_RS00145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KFV48_RS00150	COG0359	binds to the 23S rRNA
KFV48_RS00155	COG0305	Participates in initiation and elongation during chromosome replication
KFV48_RS00160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFV48_RS00175	COG0745	RESPONSE REGULATOR receiver
KFV48_RS00180	COG5002	protein histidine kinase activity
KFV48_RS00185	COG4863	YycH protein
KFV48_RS00195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFV48_RS00200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFV48_RS00205	COG1396	sequence-specific DNA binding
KFV48_RS00230	COG2113	Glycine betaine
KFV48_RS00235	COG2409	Drug exporters of the RND superfamily
KFV48_RS00245	COG2205	protein histidine kinase activity
KFV48_RS00255	COG1131	(ABC) transporter
KFV48_RS00260	COG0745	RESPONSE REGULATOR receiver
KFV48_RS00265	COG0076	glutamate decarboxylase activity
KFV48_RS00305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS00315	COG1215	transferase activity, transferring glycosyl groups
KFV48_RS00315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS00355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFV48_RS00380	COG0640	Transcriptional regulator
KFV48_RS00385	COG2217	Heavy metal translocating P-type atpase
KFV48_RS00405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV48_RS00405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV48_RS00440	COG2003	Belongs to the UPF0758 family
KFV48_RS00465	COG0730	response to heat
KFV48_RS00475	COG1388	LysM domain
KFV48_RS00490	COG3425	synthase
KFV48_RS00495	COG0584	glycerophosphoryl diester phosphodiesterase
KFV48_RS00500	COG2030	dehydratase
KFV48_RS00525	COG1846	Transcriptional regulator
KFV48_RS00525	COG1940	carbohydrate kinase activity
KFV48_RS00535	COG2210	Belongs to the sulfur carrier protein TusA family
KFV48_RS00540	COG1937	Protein conserved in bacteria
KFV48_RS00580	COG2003	Belongs to the UPF0758 family
KFV48_RS00640	COG1396	sequence-specific DNA binding
KFV48_RS00665	COG2070	2-Nitropropane dioxygenase
KFV48_RS00675	COG0477	Major facilitator Superfamily
KFV48_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV48_RS00750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV48_RS00770	COG2217	Heavy metal translocating P-type atpase
KFV48_RS00775	COG2132	Multicopper oxidase
KFV48_RS00780	COG1388	LysM domain
KFV48_RS00790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV48_RS00795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KFV48_RS00815	COG0640	Transcriptional regulator
KFV48_RS00835	COG0668	transmembrane transport
KFV48_RS00840	COG0561	phosphatase activity
KFV48_RS00870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFV48_RS00875	COG0579	oxidoreductase
KFV48_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS00890	COG1755	Isoprenylcysteine carboxyl methyltransferase
KFV48_RS00900	COG4753	response regulator
KFV48_RS00900	COG2207	Transcriptional regulator
KFV48_RS00930	COG3583	domain protein
KFV48_RS00930	COG4932	domain protein
KFV48_RS00930	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KFV48_RS00930	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KFV48_RS00930	COG3583	domain protein
KFV48_RS00930	COG4932	domain protein
KFV48_RS00940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFV48_RS00945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFV48_RS00950	COG0156	8-amino-7-oxononanoate synthase activity
KFV48_RS00955	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
KFV48_RS00980	COG0523	cobalamin synthesis protein
KFV48_RS00995	COG0803	Belongs to the bacterial solute-binding protein 9 family
KFV48_RS01005	COG3976	FMN-binding domain protein
KFV48_RS01005	COG0431	NADPH-dependent FMN reductase
KFV48_RS01005	COG1053	succinate dehydrogenase
KFV48_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS01020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KFV48_RS01050	COG0601	transmembrane transport
KFV48_RS01060	COG0444	Belongs to the ABC transporter superfamily
KFV48_RS01065	COG1124	(ABC) transporter
KFV48_RS01075	COG1882	Formate acetyltransferase
KFV48_RS01080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KFV48_RS01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV48_RS01090	COG1114	Component of the transport system for branched-chain amino acids
KFV48_RS01095	COG1309	transcriptional regulator
KFV48_RS01100	COG3246	L-lysine catabolic process to acetate
KFV48_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFV48_RS01140	COG1288	antiporter activity
KFV48_RS01145	COG0549	Belongs to the carbamate kinase family
KFV48_RS01150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFV48_RS01165	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KFV48_RS01170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFV48_RS01180	COG2376	Dihydroxyacetone kinase
KFV48_RS01185	COG1461	Dihydroxyacetone kinase
KFV48_RS01190	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KFV48_RS01205	COG2814	Major facilitator Superfamily
KFV48_RS01235	COG2814	Major facilitator Superfamily
KFV48_RS01250	COG2962	Rard protein
KFV48_RS01255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFV48_RS01260	COG0471	metal ion transport
KFV48_RS01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV48_RS01270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV48_RS01275	COG0022	dehydrogenase e1 component
KFV48_RS01280	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV48_RS01305	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KFV48_RS01310	COG1054	Belongs to the UPF0176 family
KFV48_RS01315	COG3386	PFAM SMP-30 Gluconolaconase
KFV48_RS01320	COG2353	YceI-like domain
KFV48_RS01325	COG0579	oxidoreductase
KFV48_RS01350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KFV48_RS01355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KFV48_RS01360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFV48_RS01365	COG0131	Imidazoleglycerol-phosphate dehydratase
KFV48_RS01370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFV48_RS01375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFV48_RS01380	COG0107	imidazoleglycerol-phosphate synthase activity
KFV48_RS01385	COG0140	phosphoribosyl-ATP diphosphatase activity
KFV48_RS01385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFV48_RS01390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KFV48_RS01395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KFV48_RS01405	COG0726	polysaccharide deacetylase
KFV48_RS01430	COG2814	Major facilitator Superfamily
KFV48_RS01435	COG0737	Belongs to the 5'-nucleotidase family
KFV48_RS01450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KFV48_RS01455	COG3639	organic phosphonate transmembrane transporter activity
KFV48_RS01475	COG0201	protein transport
KFV48_RS01485	COG1073	alpha beta
KFV48_RS01495	COG0653	protein targeting
KFV48_RS01500	COG0438	transferase activity, transferring glycosyl groups
KFV48_RS01525	COG2814	Major facilitator Superfamily
KFV48_RS01530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFV48_RS01545	COG1764	response to oxidative stress
KFV48_RS01555	COG3942	CHAP domain
KFV48_RS01555	COG1705	Flagellar rod assembly protein muramidase FlgJ
KFV48_RS01565	COG1482	cell wall glycoprotein biosynthetic process
KFV48_RS01570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV48_RS01570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV48_RS01570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV48_RS01575	COG3711	transcriptional antiterminator
KFV48_RS01575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV48_RS01610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV48_RS01615	COG3227	Zinc metalloprotease (Elastase)
KFV48_RS01620	COG1438	arginine binding
KFV48_RS01625	COG2235	arginine
KFV48_RS01630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFV48_RS01640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFV48_RS01650	COG2843	Capsule synthesis protein
KFV48_RS01655	COG3961	Belongs to the TPP enzyme family
KFV48_RS01680	COG1196	nuclear chromosome segregation
KFV48_RS01690	COG4195	phage-related replication protein
KFV48_RS01705	COG0702	epimerase
KFV48_RS01710	COG1785	Belongs to the alkaline phosphatase family
KFV48_RS01730	COG2205	protein histidine kinase activity
KFV48_RS01735	COG1136	(ABC) transporter
KFV48_RS01750	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFV48_RS01775	COG1846	Transcriptional regulator
KFV48_RS01785	COG0386	Belongs to the glutathione peroxidase family
KFV48_RS01790	COG0175	sulfate reduction
KFV48_RS01795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KFV48_RS01800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFV48_RS01815	COG0730	response to heat
KFV48_RS01820	COG2046	Belongs to the sulfate adenylyltransferase family
KFV48_RS01825	COG0529	Catalyzes the synthesis of activated sulfate
KFV48_RS01835	COG1328	CTP reductase activity
KFV48_RS01840	COG0602	queuosine metabolic process
KFV48_RS01845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KFV48_RS01855	COG1510	regulation of RNA biosynthetic process
KFV48_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS01865	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KFV48_RS01870	COG1473	amidohydrolase
KFV48_RS01885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFV48_RS01890	COG0574	Belongs to the PEP-utilizing enzyme family
KFV48_RS01890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFV48_RS01895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFV48_RS01900	COG0579	oxidoreductase
KFV48_RS01910	COG3588	fructose-bisphosphate aldolase
KFV48_RS01915	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFV48_RS01945	COG0531	amino acid
KFV48_RS01950	COG0583	DNA-binding transcription factor activity
KFV48_RS01955	COG0039	L-malate dehydrogenase activity
KFV48_RS01960	COG0028	Belongs to the TPP enzyme family
KFV48_RS01965	COG3527	Alpha-acetolactate decarboxylase
KFV48_RS01975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFV48_RS01980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KFV48_RS01985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KFV48_RS02000	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFV48_RS02015	COG0167	dihydroorotate dehydrogenase activity
KFV48_RS02020	COG3001	Fructosamine kinase
KFV48_RS02025	COG1113	amino acid transport
KFV48_RS02040	COG0741	lytic transglycosylase activity
KFV48_RS02050	COG3942	CHAP domain
KFV48_RS02055	COG0436	Aminotransferase
KFV48_RS02065	COG2608	mercury ion transmembrane transporter activity
KFV48_RS02070	COG2217	Heavy metal translocating P-type atpase
KFV48_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS02085	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS02110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFV48_RS02115	COG3425	synthase
KFV48_RS02135	COG0583	DNA-binding transcription factor activity
KFV48_RS02140	COG1380	Effector of murein hydrolase LrgA
KFV48_RS02145	COG1346	cytolysis
KFV48_RS02150	COG0028	Belongs to the TPP enzyme family
KFV48_RS02155	COG2190	(PTS) system
KFV48_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV48_RS02155	COG1263	PTS System
KFV48_RS02170	COG1063	alcohol dehydrogenase
KFV48_RS02180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFV48_RS02195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFV48_RS02205	COG2843	Capsule synthesis protein
KFV48_RS02220	COG4975	Glucose uptake
KFV48_RS02225	COG1869	D-ribose catabolic process
KFV48_RS02235	COG1070	Carbohydrate kinase
KFV48_RS02250	COG1760	l-serine dehydratase
KFV48_RS02255	COG1760	l-serine dehydratase
KFV48_RS02280	COG3764	Sortase (surface protein transpeptidase)
KFV48_RS02290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV48_RS02295	COG0778	Nitroreductase
KFV48_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS02310	COG2514	catechol 2,3-dioxygenase activity
KFV48_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS02330	COG3949	Membrane
KFV48_RS02340	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KFV48_RS02345	COG0586	Pfam SNARE associated Golgi protein
KFV48_RS02350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFV48_RS02355	COG2022	thiamine diphosphate biosynthetic process
KFV48_RS02365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFV48_RS02375	COG2271	Major facilitator Superfamily
KFV48_RS02390	COG4876	unkown
KFV48_RS02395	COG2357	RelA SpoT domain protein
KFV48_RS02410	COG0789	Transcriptional regulator
KFV48_RS02420	COG1802	Transcriptional regulator
KFV48_RS02430	COG2610	gluconate transmembrane transporter activity
KFV48_RS02435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KFV48_RS02440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFV48_RS02445	COG0438	transferase activity, transferring glycosyl groups
KFV48_RS02450	COG0494	nUDIX hydrolase
KFV48_RS02455	COG0556	nucleotide-excision repair
KFV48_RS02470	COG4221	oxidoreductase activity
KFV48_RS02475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV48_RS02480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFV48_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS02500	COG1363	Peptidase, m42
KFV48_RS02510	COG0069	glutamate synthase activity
KFV48_RS02525	COG4619	ABC transporter
KFV48_RS02530	COG0390	transport system, permease component
KFV48_RS02535	COG2814	Major facilitator Superfamily
KFV48_RS02540	COG2272	Belongs to the type-B carboxylesterase lipase family
KFV48_RS02545	COG0531	amino acid
KFV48_RS02555	COG1063	alcohol dehydrogenase
KFV48_RS02575	COG1174	glycine betaine transport
KFV48_RS02580	COG1346	cytolysis
KFV48_RS02585	COG1380	Effector of murein hydrolase LrgA
KFV48_RS02590	COG3279	Response regulator of the LytR AlgR family
KFV48_RS02595	COG3275	phosphorelay sensor kinase activity
KFV48_RS02605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFV48_RS02610	COG0706	membrane insertase activity
KFV48_RS02620	COG0531	amino acid
KFV48_RS02625	COG1113	amino acid transport
KFV48_RS02650	COG1929	Belongs to the glycerate kinase type-1 family
KFV48_RS02665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KFV48_RS02670	COG0588	phosphoglycerate mutase activity
KFV48_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFV48_RS02685	COG0765	amino acid transport
KFV48_RS02690	COG1126	abc transporter atp-binding protein
KFV48_RS02700	COG2348	transferase activity, transferring amino-acyl groups
KFV48_RS02720	COG2116	formate transmembrane transporter activity
KFV48_RS02725	COG0454	-acetyltransferase
KFV48_RS02735	COG0747	negative chemotaxis
KFV48_RS02745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFV48_RS02750	COG2146	nitrite reductase [NAD(P)H] activity
KFV48_RS02760	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KFV48_RS02765	COG1140	nitrate reductase beta subunit
KFV48_RS02775	COG2181	nitrate reductase activity
KFV48_RS02785	COG4585	Histidine kinase
KFV48_RS02790	COG2197	response regulator
KFV48_RS02795	COG2223	nitrite transmembrane transporter activity
KFV48_RS02800	COG1846	Transcriptional regulator
KFV48_RS02825	COG3871	stress protein (general stress protein 26)
KFV48_RS02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV48_RS02840	COG1263	PTS System
KFV48_RS02875	COG0604	alcohol dehydrogenase
KFV48_RS02880	COG0456	acetyltransferase
KFV48_RS02885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS02885	COG0463	Glycosyl transferase, family 2
KFV48_RS02895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS02895	COG0463	Glycosyl transferase, family 2
KFV48_RS02900	COG1620	l-lactate permease
KFV48_RS02905	COG0438	transferase activity, transferring glycosyl groups
KFV48_RS02910	COG0579	oxidoreductase
KFV48_RS02915	COG3850	Histidine kinase
KFV48_RS02915	COG5002	protein histidine kinase activity
KFV48_RS02920	COG0745	RESPONSE REGULATOR receiver
KFV48_RS02925	COG0577	efflux transmembrane transporter activity
KFV48_RS02930	COG1136	(ABC) transporter
KFV48_RS02945	COG4640	response to antibiotic
KFV48_RS02950	COG2814	Major facilitator Superfamily
KFV48_RS02960	COG1566	PFAM secretion protein HlyD family protein
KFV48_RS02965	COG2814	Major facilitator Superfamily
KFV48_RS02975	COG0657	acetylesterase activity
KFV48_RS02990	COG0598	Magnesium transport protein CorA
KFV48_RS02995	COG1304	FMN binding
KFV48_RS03000	COG0786	glutamate:sodium symporter activity
KFV48_RS03020	COG2094	Belongs to the DNA glycosylase MPG family
KFV48_RS03030	COG1069	ribulokinase activity
KFV48_RS03035	COG2017	converts alpha-aldose to the beta-anomer
KFV48_RS03040	COG2258	MOSC domain
KFV48_RS03045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFV48_RS03055	COG1266	CAAX protease self-immunity
KFV48_RS03060	COG0010	Belongs to the arginase family
KFV48_RS03065	COG1473	amidohydrolase
KFV48_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS03075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFV48_RS03105	COG1737	Transcriptional regulator
KFV48_RS03110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV48_RS03110	COG1263	PTS System
KFV48_RS03120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFV48_RS03145	COG1113	amino acid transport
KFV48_RS03155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV48_RS03155	COG1263	PTS System
KFV48_RS03160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KFV48_RS03175	COG1266	CAAX protease self-immunity
KFV48_RS03180	COG2378	regulation of single-species biofilm formation
KFV48_RS03185	COG0483	inositol monophosphate 1-phosphatase activity
KFV48_RS03190	COG1316	TRANSCRIPTIONal
KFV48_RS03210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV48_RS03215	COG2076	Multidrug Resistance protein
KFV48_RS03220	COG2076	Multidrug Resistance protein
KFV48_RS03225	COG3942	CHAP domain
KFV48_RS03240	COG1757	Na H antiporter
KFV48_RS03245	COG3942	CHAP domain
KFV48_RS03270	COG0829	nickel cation binding
KFV48_RS03275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFV48_RS03280	COG0830	nickel cation binding
KFV48_RS03285	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KFV48_RS03290	COG0804	urea catabolic process
KFV48_RS03295	COG0832	Belongs to the urease beta subunit family
KFV48_RS03300	COG0831	urea catabolic process
KFV48_RS03310	COG1960	acyl-CoA dehydrogenase activity
KFV48_RS03320	COG1268	BioY protein
KFV48_RS03335	COG0725	ABC transporter, periplasmic molybdate-binding protein
KFV48_RS03340	COG4149	molybdate abc transporter
KFV48_RS03345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KFV48_RS03350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFV48_RS03355	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFV48_RS03360	COG0315	cyclic pyranopterin monophosphate synthase activity
KFV48_RS03365	COG0303	'Molybdopterin
KFV48_RS03375	COG0314	molybdopterin synthase activity
KFV48_RS03385	COG0746	molybdenum cofactor guanylyltransferase activity
KFV48_RS03390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFV48_RS03410	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFV48_RS03415	COG0561	phosphatase activity
KFV48_RS03430	COG0542	response to heat
KFV48_RS03445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFV48_RS03460	COG0601	transmembrane transport
KFV48_RS03465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFV48_RS03470	COG0444	Belongs to the ABC transporter superfamily
KFV48_RS03475	COG4608	Belongs to the ABC transporter superfamily
KFV48_RS03480	COG4166	transmembrane transport
KFV48_RS03485	COG0180	Tryptophanyl-tRNA synthetase
KFV48_RS03490	COG1393	Belongs to the ArsC family
KFV48_RS03500	COG4862	establishment of competence for transformation
KFV48_RS03510	COG1164	Oligoendopeptidase f
KFV48_RS03515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFV48_RS03520	COG2346	COG2346, Truncated hemoglobins
KFV48_RS03535	COG2357	RelA SpoT domain protein
KFV48_RS03540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFV48_RS03545	COG0564	pseudouridine synthase activity
KFV48_RS03550	COG2239	Acts as a magnesium transporter
KFV48_RS03555	COG0569	domain protein
KFV48_RS03555	COG0475	glutathione-regulated potassium exporter activity
KFV48_RS03610	COG0628	permease
KFV48_RS03615	COG2382	esterase
KFV48_RS03620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KFV48_RS03625	COG2814	Major facilitator Superfamily
KFV48_RS03630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFV48_RS03635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFV48_RS03645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFV48_RS03650	COG0861	Integral membrane protein TerC family
KFV48_RS03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFV48_RS03660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFV48_RS03675	COG4873	Protein conserved in bacteria
KFV48_RS03735	COG2314	TM2 domain
KFV48_RS03740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFV48_RS03745	COG1575	Belongs to the MenA family. Type 1 subfamily
KFV48_RS03750	COG1169	isochorismate synthase
KFV48_RS03755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KFV48_RS03765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KFV48_RS03770	COG0436	Aminotransferase
KFV48_RS03775	COG3594	Acyltransferase
KFV48_RS03800	COG1316	TRANSCRIPTIONal
KFV48_RS03815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KFV48_RS03820	COG1845	cytochrome c oxidase, subunit III
KFV48_RS03825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFV48_RS03830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFV48_RS03840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFV48_RS03845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFV48_RS03850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFV48_RS03855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFV48_RS03860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFV48_RS03865	COG0047	phosphoribosylformylglycinamidine synthase activity
KFV48_RS03870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFV48_RS03875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KFV48_RS03880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KFV48_RS03885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFV48_RS03890	COG0138	bifunctional purine biosynthesis protein purh
KFV48_RS03895	COG0151	Belongs to the GarS family
KFV48_RS03900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KFV48_RS03905	COG4172	Belongs to the ABC transporter superfamily
KFV48_RS03915	COG4716	Myosin-crossreactive antigen
KFV48_RS03940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV48_RS03945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFV48_RS03955	COG1271	oxidase subunit
KFV48_RS03960	COG1294	oxidase, subunit
KFV48_RS03965	COG0569	domain protein
KFV48_RS03970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFV48_RS03975	COG5503	Protein of unknown function (DUF1447)
KFV48_RS03980	COG0242	peptide deformylase activity
KFV48_RS03990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV48_RS03995	COG0022	dehydrogenase e1 component
KFV48_RS04000	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV48_RS04010	COG4476	Belongs to the UPF0223 family
KFV48_RS04020	COG3842	ATPase activity
KFV48_RS04025	COG1176	ABC-type spermidine putrescine transport system, permease component I
KFV48_RS04050	COG1914	H( )-stimulated, divalent metal cation uptake system
KFV48_RS04055	COG4493	Belongs to the UPF0637 family
KFV48_RS04060	COG0483	inositol monophosphate 1-phosphatase activity
KFV48_RS04070	COG1217	gtp-binding protein TYPA
KFV48_RS04085	COG4896	Protein conserved in bacteria
KFV48_RS04090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFV48_RS04095	COG4838	Belongs to the UPF0358 family
KFV48_RS04100	COG0772	Belongs to the SEDS family
KFV48_RS04110	COG1612	heme a metabolic process
KFV48_RS04115	COG0109	protoheme IX farnesyltransferase activity
KFV48_RS04125	COG2340	Cysteine-rich secretory protein family
KFV48_RS04130	COG3679	Belongs to the UPF0342 family
KFV48_RS04135	COG0584	glycerophosphoryl diester phosphodiesterase
KFV48_RS04140	COG4471	UPF0298 protein
KFV48_RS04150	COG0742	ribosomal rna small subunit methyltransferase
KFV48_RS04155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFV48_RS04160	COG1323	Belongs to the UPF0348 family
KFV48_RS04170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFV48_RS04180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFV48_RS04185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFV48_RS04190	COG0072	phenylalanine-tRNA ligase activity
KFV48_RS04190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV48_RS04195	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFV48_RS04200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KFV48_RS04210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KFV48_RS04210	COG1796	DNA polymerase
KFV48_RS04215	COG1193	negative regulation of DNA recombination
KFV48_RS04220	COG3118	belongs to the thioredoxin family
KFV48_RS04225	COG0322	excinuclease ABC activity
KFV48_RS04230	COG2009	succinate dehydrogenase
KFV48_RS04235	COG1053	succinate dehydrogenase
KFV48_RS04240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFV48_RS04245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFV48_RS04250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFV48_RS04280	COG1011	Hydrolase
KFV48_RS04285	COG0454	-acetyltransferase
KFV48_RS04290	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KFV48_RS04295	COG2001	Belongs to the MraZ family
KFV48_RS04300	COG0275	rRNA processing
KFV48_RS04305	COG4839	cell division protein FtsL
KFV48_RS04310	COG0768	penicillin binding
KFV48_RS04315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFV48_RS04320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFV48_RS04325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KFV48_RS04330	COG0849	cell division
KFV48_RS04335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFV48_RS04340	COG1496	oxidoreductase activity
KFV48_RS04345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFV48_RS04350	COG1799	cell septum assembly
KFV48_RS04355	COG0762	integral membrane protein
KFV48_RS04365	COG3599	regulation of cell shape
KFV48_RS04370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFV48_RS04380	COG1388	LysM domain
KFV48_RS04380	COG3942	CHAP domain
KFV48_RS04385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFV48_RS04390	COG0564	pseudouridine synthase activity
KFV48_RS04395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KFV48_RS04400	COG2233	PERMEase
KFV48_RS04405	COG0540	Belongs to the ATCase OTCase family
KFV48_RS04410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFV48_RS04415	COG0505	Belongs to the CarA family
KFV48_RS04420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFV48_RS04425	COG0284	orotidine-5'-phosphate decarboxylase activity
KFV48_RS04430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFV48_RS04450	COG0194	GDP metabolic process
KFV48_RS04455	COG1758	RNA polymerase activity
KFV48_RS04460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KFV48_RS04465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFV48_RS04475	COG0242	peptide deformylase activity
KFV48_RS04480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFV48_RS04485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFV48_RS04485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFV48_RS04490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFV48_RS04495	COG0631	protein serine/threonine phosphatase activity
KFV48_RS04505	COG1162	GTPase activity
KFV48_RS04510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFV48_RS04520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFV48_RS04525	COG1302	Protein conserved in bacteria
KFV48_RS04530	COG1461	Dihydroxyacetone kinase
KFV48_RS04535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFV48_RS04540	COG1349	DNA-binding transcription factor activity
KFV48_RS04545	COG0416	fatty acid biosynthetic process
KFV48_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS04560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFV48_RS04565	COG0571	ribonuclease III activity
KFV48_RS04570	COG1196	nuclear chromosome segregation
KFV48_RS04575	COG0552	protein localization to endoplasmic reticulum
KFV48_RS04580	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KFV48_RS04585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFV48_RS04590	COG0228	four-way junction DNA binding
KFV48_RS04595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFV48_RS04600	COG0336	Belongs to the RNA methyltransferase TrmD family
KFV48_RS04605	COG0335	large ribosomal subunit rRNA binding
KFV48_RS04615	COG4485	Bacterial membrane protein, YfhO
KFV48_RS04625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFV48_RS04630	COG0045	succinate-CoA ligase (ADP-forming) activity
KFV48_RS04635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KFV48_RS04640	COG0758	DNA mediated transformation
KFV48_RS04645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFV48_RS04650	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KFV48_RS04655	COG4974	Belongs to the 'phage' integrase family
KFV48_RS04660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KFV48_RS04665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KFV48_RS04670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KFV48_RS04675	COG0052	Belongs to the universal ribosomal protein uS2 family
KFV48_RS04680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFV48_RS04685	COG0528	UMP kinase activity
KFV48_RS04690	COG0233	cytoplasmic translational termination
KFV48_RS04695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFV48_RS04700	COG4589	Belongs to the CDS family
KFV48_RS04710	COG0442	prolyl-tRNA aminoacylation
KFV48_RS04715	COG2176	DNA-directed DNA polymerase activity
KFV48_RS04720	COG0779	Required for maturation of 30S ribosomal subunits
KFV48_RS04725	COG0195	Participates in both transcription termination and antitermination
KFV48_RS04730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KFV48_RS04735	COG1358	cellular component organization or biogenesis
KFV48_RS04740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFV48_RS04745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFV48_RS04750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFV48_RS04755	COG0196	riboflavin kinase activity
KFV48_RS04760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFV48_RS04765	COG1185	polyribonucleotide nucleotidyltransferase activity
KFV48_RS04770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KFV48_RS04775	COG1674	ftsk spoiiie
KFV48_RS04780	COG2188	Transcriptional regulator
KFV48_RS04785	COG0612	Peptidase, M16
KFV48_RS04790	COG0612	Peptidase, M16
KFV48_RS04795	COG0300	oxidoreductase activity
KFV48_RS04810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFV48_RS04820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFV48_RS04825	COG1418	mRNA catabolic process
KFV48_RS04835	COG1692	metallophosphoesterase
KFV48_RS04840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFV48_RS04840	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFV48_RS04845	COG1013	pyruvate-flavodoxin oxidoreductase activity
KFV48_RS04850	COG4195	phage-related replication protein
KFV48_RS04860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFV48_RS04865	COG4550	Control of competence regulator ComK, YlbF/YmcA
KFV48_RS04875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFV48_RS04880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFV48_RS04885	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KFV48_RS04890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KFV48_RS04895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KFV48_RS04900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KFV48_RS04910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFV48_RS04915	COG1923	regulation of RNA biosynthetic process
KFV48_RS04920	COG0386	Belongs to the glutathione peroxidase family
KFV48_RS04925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFV48_RS04930	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KFV48_RS04935	COG0789	Transcriptional regulator
KFV48_RS04940	COG0174	glutamine synthetase
KFV48_RS05000	COG0629	single-stranded DNA binding
KFV48_RS05025	COG1595	DNA-templated transcription, initiation
KFV48_RS05145	COG4824	toxin secretion phage lysis holin
KFV48_RS05205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFV48_RS05210	COG1131	(ABC) transporter
KFV48_RS05220	COG4585	Histidine kinase
KFV48_RS05225	COG2197	response regulator
KFV48_RS05235	COG1525	nuclease
KFV48_RS05250	COG0527	aspartate kinase activity
KFV48_RS05255	COG0460	homoserine dehydrogenase
KFV48_RS05260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KFV48_RS05265	COG0083	homoserine kinase activity
KFV48_RS05280	COG0833	amino acid
KFV48_RS05285	COG0753	catalase activity
KFV48_RS05295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFV48_RS05300	COG0516	GMP reductase activity
KFV48_RS05305	COG2340	Cysteine-rich secretory protein family
KFV48_RS05310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFV48_RS05320	COG4224	UPF0291 protein
KFV48_RS05325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KFV48_RS05335	COG4846	Membrane protein involved in cytochrome C biogenesis
KFV48_RS05340	COG0420	3'-5' exonuclease activity
KFV48_RS05345	COG0419	ATPase involved in DNA repair
KFV48_RS05350	COG1970	mechanosensitive ion channel activity
KFV48_RS05355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFV48_RS05360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KFV48_RS05365	COG0824	Thioesterase
KFV48_RS05375	COG4841	protein insertion into membrane
KFV48_RS05380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KFV48_RS05385	COG0187	DNA topoisomerase II activity
KFV48_RS05390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFV48_RS05395	COG1115	amino acid carrier protein
KFV48_RS05400	COG3711	transcriptional antiterminator
KFV48_RS05405	COG0628	permease
KFV48_RS05410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KFV48_RS05410	COG0392	lysyltransferase activity
KFV48_RS05425	COG1942	4-Oxalocrotonate Tautomerase
KFV48_RS05430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFV48_RS05435	COG0287	Prephenate dehydrogenase
KFV48_RS05440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFV48_RS05445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFV48_RS05445	COG0512	Glutamine amidotransferase of anthranilate synthase
KFV48_RS05450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFV48_RS05455	COG0134	indole-3-glycerol-phosphate synthase activity
KFV48_RS05460	COG0135	phosphoribosylanthranilate isomerase activity
KFV48_RS05465	COG0133	tryptophan synthase activity
KFV48_RS05470	COG0159	tryptophan synthase activity
KFV48_RS05480	COG2348	transferase activity, transferring amino-acyl groups
KFV48_RS05485	COG2348	transferase activity, transferring amino-acyl groups
KFV48_RS05495	COG4607	ABC-type enterochelin transport system periplasmic component
KFV48_RS05530	COG0704	Plays a role in the regulation of phosphate uptake
KFV48_RS05535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFV48_RS05540	COG0581	inorganic phosphate transmembrane transporter activity
KFV48_RS05545	COG0573	inorganic phosphate transmembrane transporter activity
KFV48_RS05550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KFV48_RS05555	COG2996	Protein conserved in bacteria
KFV48_RS05560	COG0488	(ABC) transporter
KFV48_RS05565	COG0527	aspartate kinase activity
KFV48_RS05570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFV48_RS05575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFV48_RS05580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFV48_RS05585	COG2171	N-acyltransferase activity
KFV48_RS05590	COG1473	amidohydrolase
KFV48_RS05610	COG1131	(ABC) transporter
KFV48_RS05625	COG1278	Cold shock
KFV48_RS05635	COG1254	Belongs to the acylphosphatase family
KFV48_RS05645	COG3853	Toxic anion resistance protein (TelA)
KFV48_RS05650	COG1114	Component of the transport system for branched-chain amino acids
KFV48_RS05655	COG4548	von Willebrand factor, type A
KFV48_RS05660	COG0714	Associated with various cellular activities
KFV48_RS05685	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV48_RS05690	COG0567	Dehydrogenase, E1 component
KFV48_RS05695	COG5002	protein histidine kinase activity
KFV48_RS05700	COG0745	RESPONSE REGULATOR receiver
KFV48_RS05705	COG1349	DNA-binding transcription factor activity
KFV48_RS05710	COG0534	Mate efflux family protein
KFV48_RS05720	COG0395	ABC-type sugar transport system, permease component
KFV48_RS05730	COG4209	transmembrane transport
KFV48_RS05735	COG3842	ATPase activity
KFV48_RS05740	COG0671	phosphoesterase, PA-phosphatase related
KFV48_RS05745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFV48_RS05755	COG0793	Belongs to the peptidase S41A family
KFV48_RS05760	COG4479	Belongs to the UPF0346 family
KFV48_RS05765	COG2190	(PTS) system
KFV48_RS05770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFV48_RS05795	COG1136	(ABC) transporter
KFV48_RS05810	COG1413	lyase activity
KFV48_RS05820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KFV48_RS05835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV48_RS05840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KFV48_RS05850	COG0116	Belongs to the methyltransferase superfamily
KFV48_RS05860	COG3599	regulation of cell shape
KFV48_RS05865	COG4474	Belongs to the UPF0398 family
KFV48_RS05875	COG3331	DNA recombination
KFV48_RS05880	COG4499	WXG100 protein secretion system (Wss), protein YukC
KFV48_RS05880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFV48_RS05890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFV48_RS05895	COG3935	DnaD domain protein
KFV48_RS05900	COG0017	Asparaginyl-tRNA synthetase
KFV48_RS05905	COG1199	ATP-dependent helicase activity
KFV48_RS05905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFV48_RS05910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KFV48_RS05910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KFV48_RS05915	COG0617	tRNA 3'-terminal CCA addition
KFV48_RS05920	COG0438	transferase activity, transferring glycosyl groups
KFV48_RS05925	COG1694	Mazg nucleotide pyrophosphohydrolase
KFV48_RS05930	COG2738	Putative neutral zinc metallopeptidase
KFV48_RS05935	COG4347	Protein of unknown function (DUF1405)
KFV48_RS05940	COG5582	Belongs to the UPF0302 family
KFV48_RS05950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFV48_RS05955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFV48_RS05960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFV48_RS05965	COG0105	UTP biosynthetic process
KFV48_RS05975	COG2226	methyltransferase
KFV48_RS05990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFV48_RS05995	COG1160	GTP binding
KFV48_RS06000	COG0539	negative regulation of cytoplasmic translation
KFV48_RS06005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFV48_RS06010	COG0252	asparaginase activity
KFV48_RS06015	COG0492	ferredoxin-NADP+ reductase activity
KFV48_RS06020	COG1388	LysM domain
KFV48_RS06025	COG0514	ATP-dependent DNA helicase (RecQ)
KFV48_RS06035	COG1141	Ferredoxin
KFV48_RS06050	COG0745	RESPONSE REGULATOR receiver
KFV48_RS06055	COG1187	pseudouridine synthase activity
KFV48_RS06060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFV48_RS06065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KFV48_RS06070	COG1547	Domain of unknown function (DUF309)
KFV48_RS06075	COG4974	Belongs to the 'phage' integrase family
KFV48_RS06080	COG0735	belongs to the Fur family
KFV48_RS06085	COG0494	nUDIX hydrolase
KFV48_RS06090	COG0667	Aldo Keto reductase
KFV48_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS06100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KFV48_RS06105	COG1234	tRNA 3'-trailer cleavage
KFV48_RS06110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KFV48_RS06120	COG0366	Alpha amylase catalytic
KFV48_RS06125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KFV48_RS06130	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFV48_RS06140	COG4129	membrane
KFV48_RS06150	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFV48_RS06155	COG0022	dehydrogenase e1 component
KFV48_RS06160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFV48_RS06165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV48_RS06170	COG0497	DNA recombination
KFV48_RS06175	COG1438	arginine binding
KFV48_RS06185	COG1722	exodeoxyribonuclease VII activity
KFV48_RS06190	COG1570	exodeoxyribonuclease VII activity
KFV48_RS06195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFV48_RS06200	COG1302	Protein conserved in bacteria
KFV48_RS06205	COG0439	Biotin carboxylase
KFV48_RS06210	COG0511	ligase activity, forming carbon-carbon bonds
KFV48_RS06215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFV48_RS06220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFV48_RS06225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KFV48_RS06230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFV48_RS06235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFV48_RS06240	COG0006	proline dipeptidase activity
KFV48_RS06255	COG0095	Lipoate-protein ligase
KFV48_RS06260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFV48_RS06270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFV48_RS06275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFV48_RS06280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KFV48_RS06285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFV48_RS06305	COG4537	Required for transformation and DNA binding
KFV48_RS06310	COG1459	type II secretion system
KFV48_RS06315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFV48_RS06325	COG0011	TIGRFAM Protein of
KFV48_RS06330	COG1940	carbohydrate kinase activity
KFV48_RS06335	COG4483	Protein conserved in bacteria
KFV48_RS06345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFV48_RS06350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFV48_RS06355	COG0768	penicillin binding
KFV48_RS06360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFV48_RS06365	COG0735	belongs to the Fur family
KFV48_RS06370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFV48_RS06375	COG1121	(ABC) transporter
KFV48_RS06380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KFV48_RS06385	COG0513	Belongs to the DEAD box helicase family
KFV48_RS06390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFV48_RS06395	COG2384	SAM-dependent methyltransferase
KFV48_RS06400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFV48_RS06405	COG0358	DNA primase activity
KFV48_RS06410	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KFV48_RS06415	COG0517	IMP dehydrogenase activity
KFV48_RS06420	COG0423	glycine-tRNA ligase activity
KFV48_RS06425	COG1381	Involved in DNA repair and RecF pathway recombination
KFV48_RS06430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFV48_RS06435	COG0295	cytidine deaminase activity
KFV48_RS06440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KFV48_RS06445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFV48_RS06450	COG1702	phosphate starvation-inducible protein PhoH
KFV48_RS06460	COG4864	UPF0365 protein
KFV48_RS06465	COG1030	water channel activity
KFV48_RS06475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFV48_RS06480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFV48_RS06485	COG2264	protein methyltransferase activity
KFV48_RS06490	COG0484	heat shock protein binding
KFV48_RS06495	COG0443	Heat shock 70 kDa protein
KFV48_RS06500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFV48_RS06505	COG1420	regulation of RNA biosynthetic process
KFV48_RS06510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFV48_RS06515	COG0481	GTPase activity
KFV48_RS06520	COG0268	Binds directly to 16S ribosomal RNA
KFV48_RS06525	COG1466	dna polymerase III delta subunit
KFV48_RS06530	COG2333	competence protein COMEC
KFV48_RS06530	COG0658	competence protein
KFV48_RS06535	COG2131	deaminase
KFV48_RS06545	COG2226	methyltransferase
KFV48_RS06550	COG0799	negative regulation of ribosome biogenesis
KFV48_RS06555	COG1713	HD superfamily hydrolase involved in NAD metabolism
KFV48_RS06560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFV48_RS06565	COG1534	Rna-binding protein
KFV48_RS06570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFV48_RS06575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KFV48_RS06580	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KFV48_RS06585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KFV48_RS06590	COG1914	H( )-stimulated, divalent metal cation uptake system
KFV48_RS06595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KFV48_RS06600	COG0439	Biotin carboxylase
KFV48_RS06605	COG0511	ligase activity, forming carbon-carbon bonds
KFV48_RS06610	COG1984	allophanate hydrolase subunit 2
KFV48_RS06615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KFV48_RS06625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFV48_RS06630	COG0572	uridine kinase
KFV48_RS06635	COG0826	peptidase U32
KFV48_RS06640	COG0826	peptidase U32
KFV48_RS06650	COG3906	Belongs to the UPF0473 family
KFV48_RS06655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFV48_RS06660	COG4472	Bacterial protein of unknown function (DUF965)
KFV48_RS06665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFV48_RS06670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV48_RS06680	COG0482	sulfurtransferase activity
KFV48_RS06685	COG1104	cysteine desulfurase activity
KFV48_RS06690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV48_RS06700	COG1959	2 iron, 2 sulfur cluster binding
KFV48_RS06705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFV48_RS06710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KFV48_RS06720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFV48_RS06725	COG0124	histidyl-tRNA synthetase
KFV48_RS06730	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFV48_RS06735	COG1490	D-aminoacyl-tRNA deacylase activity
KFV48_RS06740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFV48_RS06745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV48_RS06750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KFV48_RS06750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFV48_RS06755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFV48_RS06755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFV48_RS06760	COG1862	Preprotein translocase
KFV48_RS06765	COG0343	queuine tRNA-ribosyltransferase activity
KFV48_RS06770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFV48_RS06775	COG2255	four-way junction helicase activity
KFV48_RS06780	COG0632	four-way junction helicase activity
KFV48_RS06785	COG4492	Belongs to the UPF0735 family
KFV48_RS06790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFV48_RS06795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFV48_RS06800	COG2868	ribosomal protein
KFV48_RS06805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFV48_RS06815	COG1792	Involved in formation and maintenance of cell shape
KFV48_RS06835	COG2003	Belongs to the UPF0758 family
KFV48_RS06845	COG0285	dihydrofolate synthase activity
KFV48_RS06850	COG0525	valine-tRNA ligase activity
KFV48_RS06855	COG2818	Glycosylase
KFV48_RS06865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFV48_RS06870	COG0113	porphobilinogen synthase activity
KFV48_RS06880	COG0181	hydroxymethylbilane synthase activity
KFV48_RS06890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFV48_RS06895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFV48_RS06900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFV48_RS06905	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFV48_RS06915	COG4112	unkown
KFV48_RS06920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFV48_RS06925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFV48_RS06930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFV48_RS06935	COG0833	amino acid
KFV48_RS06940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFV48_RS06945	COG1484	DNA-dependent DNA replication
KFV48_RS06950	COG3611	Membrane attachment protein
KFV48_RS06955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFV48_RS06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFV48_RS06970	COG0237	dephospho-CoA kinase activity
KFV48_RS06975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFV48_RS06980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV48_RS06980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFV48_RS06985	COG5002	protein histidine kinase activity
KFV48_RS06990	COG0745	RESPONSE REGULATOR receiver
KFV48_RS06995	COG0538	isocitrate dehydrogenase activity
KFV48_RS07000	COG0372	Belongs to the citrate synthase family
KFV48_RS07005	COG1113	amino acid transport
KFV48_RS07010	COG0469	pyruvate kinase activity
KFV48_RS07015	COG0205	6-phosphofructokinase activity
KFV48_RS07020	COG0825	malonyl-CoA metabolic process
KFV48_RS07025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFV48_RS07030	COG0281	malic enzyme
KFV48_RS07035	COG0587	DNA-directed DNA polymerase activity
KFV48_RS07040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KFV48_RS07045	COG4109	DRTGG domain
KFV48_RS07055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFV48_RS07060	COG0006	proline dipeptidase activity
KFV48_RS07065	COG0686	Belongs to the AlaDH PNT family
KFV48_RS07070	COG0589	response to stress
KFV48_RS07080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KFV48_RS07085	COG0827	DNA restriction-modification system
KFV48_RS07090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KFV48_RS07100	COG0301	tRNA thio-modification
KFV48_RS07110	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KFV48_RS07115	COG1956	GAF domain-containing protein
KFV48_RS07120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFV48_RS07125	COG0584	glycerophosphoryl diester phosphodiesterase
KFV48_RS07130	COG1764	response to oxidative stress
KFV48_RS07135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFV48_RS07140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFV48_RS07150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFV48_RS07150	COG1263	PTS System
KFV48_RS07155	COG0204	Acyl-transferase
KFV48_RS07160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFV48_RS07165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFV48_RS07175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KFV48_RS07180	COG1609	Transcriptional regulator
KFV48_RS07185	COG1605	Chorismate mutase
KFV48_RS07185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KFV48_RS07195	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KFV48_RS07200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFV48_RS07205	COG1674	ftsk spoiiie
KFV48_RS07210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV48_RS07215	COG4848	Belongs to the UPF0354 family
KFV48_RS07220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFV48_RS07225	COG1363	Peptidase, m42
KFV48_RS07235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFV48_RS07240	COG0510	thiamine kinase activity
KFV48_RS07245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFV48_RS07250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFV48_RS07260	COG1187	pseudouridine synthase activity
KFV48_RS07265	COG2244	polysaccharide biosynthetic process
KFV48_RS07270	COG2081	HI0933 family
KFV48_RS07285	COG0495	leucyl-tRNA aminoacylation
KFV48_RS07290	COG2814	Major facilitator Superfamily
KFV48_RS07295	COG1242	4 iron, 4 sulfur cluster binding
KFV48_RS07300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KFV48_RS07315	COG2267	carboxylic ester hydrolase activity
KFV48_RS07320	COG0506	proline dehydrogenase activity
KFV48_RS07325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KFV48_RS07330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFV48_RS07330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFV48_RS07340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFV48_RS07340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFV48_RS07350	COG3266	domain, Protein
KFV48_RS07350	COG5632	N-Acetylmuramoyl-L-alanine amidase
KFV48_RS07350	COG4193	domain, Protein
KFV48_RS07375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFV48_RS07385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFV48_RS07390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFV48_RS07405	COG0656	L-ascorbic acid biosynthetic process
KFV48_RS07415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFV48_RS07420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFV48_RS07425	COG1506	peptidase
KFV48_RS07430	COG0494	nUDIX hydrolase
KFV48_RS07435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFV48_RS07445	COG0318	PFAM AMP-dependent synthetase and ligase
KFV48_RS07550	COG3942	CHAP domain
KFV48_RS07705	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KFV48_RS07710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFV48_RS07715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFV48_RS07720	COG2329	Antibiotic biosynthesis monooxygenase
KFV48_RS07730	COG4473	ABC transporter
KFV48_RS07735	COG1131	(ABC) transporter
KFV48_RS07740	COG0537	adenosine 5'-monophosphoramidase activity
KFV48_RS07755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFV48_RS07765	COG3481	metal-dependent phosphohydrolase, HD sub domain
KFV48_RS07775	COG0420	3'-5' exonuclease activity
KFV48_RS07780	COG3679	Belongs to the UPF0342 family
KFV48_RS07785	COG4399	Belongs to the UPF0754 family
KFV48_RS07795	COG2197	response regulator
KFV48_RS07800	COG4585	Histidine kinase
KFV48_RS07800	COG2203	Gaf domain
KFV48_RS07810	COG0114	fumarate hydratase activity
KFV48_RS07835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFV48_RS07845	COG1126	abc transporter atp-binding protein
KFV48_RS07850	COG0765	amino acid transport
KFV48_RS07880	COG4824	toxin secretion phage lysis holin
KFV48_RS07980	COG1595	DNA-templated transcription, initiation
KFV48_RS08250	COG0735	belongs to the Fur family
KFV48_RS08255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV48_RS08260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFV48_RS08265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFV48_RS08270	COG4129	membrane
KFV48_RS08280	COG3557	Belongs to the UPF0374 family
KFV48_RS08295	COG1988	membrane-bound metal-dependent
KFV48_RS08305	COG1388	LysM domain
KFV48_RS08305	COG1134	teichoic acid transport
KFV48_RS08315	COG2137	regulation of response to DNA damage stimulus
KFV48_RS08320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFV48_RS08325	COG0693	protein deglycase activity
KFV48_RS08335	COG0535	radical SAM domain protein
KFV48_RS08340	COG1607	acyl-coa hydrolase
KFV48_RS08345	COG2309	aminopeptidase activity
KFV48_RS08350	COG4840	Belongs to the UPF0435 family
KFV48_RS08355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV48_RS08365	COG1295	ribonuclease BN
KFV48_RS08370	COG2197	response regulator
KFV48_RS08375	COG4585	Histidine kinase
KFV48_RS08390	COG0024	Methionine aminopeptidase
KFV48_RS08395	COG4129	membrane
KFV48_RS08415	COG1528	Iron-storage protein
KFV48_RS08425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFV48_RS08435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFV48_RS08440	COG1597	lipid kinase activity
KFV48_RS08445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFV48_RS08450	COG0154	amidase activity
KFV48_RS08455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFV48_RS08460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFV48_RS08465	COG4851	CamS sex pheromone cAM373 precursor
KFV48_RS08470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFV48_RS08475	COG0210	DNA helicase
KFV48_RS08480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KFV48_RS08485	COG4496	protein, YerC YecD
KFV48_RS08490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KFV48_RS08500	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KFV48_RS08505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFV48_RS08510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KFV48_RS08520	COG0077	Prephenate dehydratase
KFV48_RS08530	COG1335	isochorismatase
KFV48_RS08535	COG1227	inorganic diphosphatase activity
KFV48_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS08545	COG2706	6-phosphogluconolactonase activity
KFV48_RS08550	COG3682	Transcriptional regulator
KFV48_RS08580	COG4974	Belongs to the 'phage' integrase family
KFV48_RS08630	COG1131	(ABC) transporter
KFV48_RS08640	COG1131	(ABC) transporter
KFV48_RS08645	COG1725	Transcriptional regulator
KFV48_RS08765	COG3617	BRO family, N-terminal domain
KFV48_RS08780	COG0582	viral genome integration into host DNA
KFV48_RS08785	COG0459	protein refolding
KFV48_RS08790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFV48_RS08830	COG3279	Response regulator of the LytR AlgR family
KFV48_RS08835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFV48_RS08840	COG1621	beta-fructofuranosidase activity
KFV48_RS08845	COG1609	Transcriptional regulator
KFV48_RS08850	COG0004	ammonium transporteR
KFV48_RS08855	COG0425	Belongs to the sulfur carrier protein TusA family
KFV48_RS08865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFV48_RS08905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV48_RS08930	COG1780	Probably involved in ribonucleotide reductase function
KFV48_RS08970	COG0270	DNA (cytosine-5-)-methyltransferase activity
KFV48_RS08975	COG2226	methyltransferase
KFV48_RS09040	COG0587	DNA-directed DNA polymerase activity
KFV48_RS09045	COG0587	DNA-directed DNA polymerase activity
KFV48_RS09075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFV48_RS09120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFV48_RS09255	COG0456	acetyltransferase
KFV48_RS09305	COG2887	Belongs to the helicase family. UvrD subfamily
KFV48_RS09405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV48_RS09415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KFV48_RS09445	COG4373	Mu-like prophage FluMu protein gp28
KFV48_RS09515	COG0582	viral genome integration into host DNA
KFV48_RS09530	COG2433	Pfam Transposase IS66
KFV48_RS09570	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFV48_RS09570	COG1388	LysM domain
KFV48_RS09610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KFV48_RS09615	COG0488	(ABC) transporter
KFV48_RS09620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFV48_RS09625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFV48_RS09630	COG0456	acetyltransferase
KFV48_RS09635	COG1214	PFAM Peptidase M22, glycoprotease
KFV48_RS09640	COG0802	atpase or kinase
KFV48_RS09645	COG0129	dihydroxy-acid dehydratase activity
KFV48_RS09650	COG0028	Belongs to the TPP enzyme family
KFV48_RS09660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFV48_RS09665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFV48_RS09670	COG0473	3-isopropylmalate dehydrogenase activity
KFV48_RS09675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFV48_RS09680	COG0066	3-isopropylmalate dehydratase activity
KFV48_RS09685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFV48_RS09715	COG3091	SprT-like family
KFV48_RS09720	COG2183	response to ionizing radiation
KFV48_RS09725	COG1191	sigma factor activity
KFV48_RS09740	COG2208	phosphoserine phosphatase activity
KFV48_RS09745	COG2337	Toxic component of a toxin-antitoxin (TA) module
KFV48_RS09755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFV48_RS09760	COG0736	holo-[acyl-carrier-protein] synthase activity
KFV48_RS09765	COG3402	PFAM membrane-flanked domain
KFV48_RS09770	COG3428	Bacterial PH domain
KFV48_RS09780	COG0513	Belongs to the DEAD box helicase family
KFV48_RS09785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFV48_RS09790	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFV48_RS09795	COG0772	Belongs to the SEDS family
KFV48_RS09810	COG1937	Protein conserved in bacteria
KFV48_RS09815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFV48_RS09820	COG1418	mRNA catabolic process
KFV48_RS09825	COG0706	membrane insertase activity
KFV48_RS09830	COG0352	thiamine-phosphate diphosphorylase activity
KFV48_RS09835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KFV48_RS09845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KFV48_RS09850	COG1388	LysM domain
KFV48_RS09855	COG0629	single-stranded DNA binding
KFV48_RS09865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFV48_RS09870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFV48_RS09880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KFV48_RS09885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFV48_RS09890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFV48_RS09895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFV48_RS09900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFV48_RS09905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFV48_RS09915	COG0356	it plays a direct role in the translocation of protons across the membrane
KFV48_RS09925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KFV48_RS09930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFV48_RS09935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFV48_RS09940	COG4475	Protein of unknown function (DUF436)
KFV48_RS09945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFV48_RS09950	COG0009	L-threonylcarbamoyladenylate synthase
KFV48_RS09955	COG2890	protein-(glutamine-N5) methyltransferase activity
KFV48_RS09960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFV48_RS09965	COG1435	thymidine kinase activity
KFV48_RS09970	COG0254	rRNA binding
KFV48_RS09975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KFV48_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS09985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFV48_RS09990	COG0191	fructose-bisphosphate aldolase activity
KFV48_RS10000	COG0504	CTP synthase activity
KFV48_RS10005	COG3343	RNA polymerase activity
KFV48_RS10015	COG5146	pantothenate kinase activity
KFV48_RS10035	COG1854	S-ribosylhomocysteine lyase activity
KFV48_RS10045	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KFV48_RS10050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KFV48_RS10055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFV48_RS10060	COG0813	purine-nucleoside phosphorylase activity
KFV48_RS10065	COG0783	Belongs to the Dps family
KFV48_RS10085	COG1482	cell wall glycoprotein biosynthetic process
KFV48_RS10090	COG0702	epimerase
KFV48_RS10095	COG0640	Transcriptional regulator
KFV48_RS10115	COG0561	phosphatase activity
KFV48_RS10120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFV48_RS10125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFV48_RS10135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KFV48_RS10185	COG0489	protein tyrosine kinase activity
KFV48_RS10190	COG2814	Major facilitator Superfamily
KFV48_RS10210	COG4284	Utp--glucose-1-phosphate uridylyltransferase
KFV48_RS10215	COG1988	membrane-bound metal-dependent
KFV48_RS10225	COG2329	Antibiotic biosynthesis monooxygenase
KFV48_RS10230	COG3314	Sporulation integral membrane protein YlbJ
KFV48_RS10235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV48_RS10240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV48_RS10245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KFV48_RS10250	COG3457	Alanine racemase
KFV48_RS10255	COG4264	IucA IucC family
KFV48_RS10260	COG2814	Major facilitator Superfamily
KFV48_RS10265	COG4264	IucA IucC family
KFV48_RS10270	COG1302	Protein conserved in bacteria
KFV48_RS10285	COG0604	alcohol dehydrogenase
KFV48_RS10290	COG2130	NADP-dependent
KFV48_RS10295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV48_RS10305	COG2723	6-phospho-beta-galactosidase activity
KFV48_RS10310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KFV48_RS10310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KFV48_RS10315	COG1447	Phosphotransferase system cellobiose-specific component IIA
KFV48_RS10320	COG3684	Belongs to the aldolase LacD family
KFV48_RS10325	COG1105	Belongs to the carbohydrate kinase PfkB family
KFV48_RS10330	COG0698	ribose 5-phosphate isomerase
KFV48_RS10335	COG0698	ribose 5-phosphate isomerase
KFV48_RS10340	COG1349	DNA-binding transcription factor activity
KFV48_RS10345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KFV48_RS10350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFV48_RS10355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFV48_RS10360	COG0101	tRNA pseudouridine synthase activity
KFV48_RS10370	COG1122	ATPase activity
KFV48_RS10375	COG1122	ATPase activity
KFV48_RS10380	COG0203	ribosomal protein L17
KFV48_RS10385	COG0202	RNA polymerase activity
KFV48_RS10390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFV48_RS10395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFV48_RS10400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFV48_RS10405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFV48_RS10410	COG0563	adenylate kinase activity
KFV48_RS10415	COG0201	protein transport
KFV48_RS10420	COG0200	Binds to the 23S rRNA
KFV48_RS10425	COG1841	ribosomal large subunit assembly
KFV48_RS10430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFV48_RS10435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFV48_RS10440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFV48_RS10445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFV48_RS10450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFV48_RS10455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFV48_RS10460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFV48_RS10465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFV48_RS10470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFV48_RS10480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFV48_RS10485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFV48_RS10490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFV48_RS10495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFV48_RS10500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFV48_RS10505	COG0089	rRNA binding
KFV48_RS10510	COG0088	Forms part of the polypeptide exit tunnel
KFV48_RS10515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFV48_RS10530	COG2252	PERMEase
KFV48_RS10535	COG0551	DNA topoisomerase type I activity
KFV48_RS10535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFV48_RS10545	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS10565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFV48_RS10570	COG2348	transferase activity, transferring amino-acyl groups
KFV48_RS10585	COG2814	Major facilitator Superfamily
KFV48_RS10610	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFV48_RS10615	COG1074	ATP-dependent DNA helicase activity
KFV48_RS10620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KFV48_RS10635	COG0398	Pfam SNARE associated Golgi protein
KFV48_RS10640	COG0166	Belongs to the GPI family
KFV48_RS10645	COG0137	argininosuccinate synthase activity
KFV48_RS10650	COG0165	Argininosuccinate lyase
KFV48_RS10655	COG0584	glycerophosphoryl diester phosphodiesterase
KFV48_RS10665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFV48_RS10675	COG1902	pentaerythritol trinitrate reductase activity
KFV48_RS10680	COG1098	S1 RNA binding domain
KFV48_RS10685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFV48_RS10695	COG2111	Na H antiporter
KFV48_RS10695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV48_RS10700	COG2111	Na H antiporter
KFV48_RS10705	COG1006	Multisubunit Na H antiporter MnhC subunit
KFV48_RS10710	COG0651	ATP synthesis coupled electron transport
KFV48_RS10715	COG1863	multisubunit Na H antiporter MnhE subunit
KFV48_RS10720	COG2212	antiporter activity
KFV48_RS10725	COG1320	monovalent cation:proton antiporter activity
KFV48_RS10735	COG2050	protein possibly involved in aromatic compounds catabolism
KFV48_RS10740	COG2056	Na+-H+ antiporter family
KFV48_RS10745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFV48_RS10750	COG1252	NADH dehydrogenase
KFV48_RS10755	COG0316	Belongs to the HesB IscA family
KFV48_RS10760	COG4844	belongs to the
KFV48_RS10765	COG1252	NADH dehydrogenase
KFV48_RS10770	COG4837	Protein of unknown function (DUF1462)
KFV48_RS10775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFV48_RS10780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KFV48_RS10785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFV48_RS10790	COG1696	Membrane protein involved in D-alanine export
KFV48_RS10795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KFV48_RS10805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFV48_RS10810	COG0647	UMP catabolic process
KFV48_RS10815	COG2445	Protein of unknown function DUF86
KFV48_RS10825	COG4470	Protein conserved in bacteria
KFV48_RS10830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFV48_RS10835	COG0737	Belongs to the 5'-nucleotidase family
KFV48_RS10840	COG0730	response to heat
KFV48_RS10845	COG1801	Protein of unknown function DUF72
KFV48_RS10850	COG1253	flavin adenine dinucleotide binding
KFV48_RS10865	COG0719	Fe-S assembly protein
KFV48_RS10870	COG0822	iron-sulfur transferase activity
KFV48_RS10875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFV48_RS10880	COG0719	Fe-S assembly protein
KFV48_RS10885	COG0396	ATPase activity
KFV48_RS10895	COG3237	CsbD-like
KFV48_RS10905	COG1464	Belongs to the NlpA lipoprotein family
KFV48_RS10910	COG2011	ABC-type metal ion transport system permease component
KFV48_RS10915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFV48_RS10925	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFV48_RS10930	COG0509	glycine decarboxylation via glycine cleavage system
KFV48_RS10935	COG1393	Belongs to the ArsC family
KFV48_RS10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFV48_RS10950	COG0710	3-dehydroquinate dehydratase activity
KFV48_RS10955	COG1764	response to oxidative stress
KFV48_RS11000	COG4195	phage-related replication protein
KFV48_RS11015	COG1278	Cold shock
KFV48_RS11045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFV48_RS11085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFV48_RS11090	COG0557	exoribonuclease II activity
KFV48_RS11095	COG1647	Serine aminopeptidase, S33
KFV48_RS11100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFV48_RS11110	COG0148	phosphopyruvate hydratase activity
KFV48_RS11115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFV48_RS11120	COG0149	triose-phosphate isomerase activity
KFV48_RS11125	COG0126	phosphoglycerate kinase activity
KFV48_RS11130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFV48_RS11150	COG1090	epimerase
KFV48_RS11160	COG0740	serine-type endopeptidase activity
KFV48_RS11170	COG1481	regulation of sporulation
KFV48_RS11175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KFV48_RS11180	COG1660	Displays ATPase and GTPase activities
KFV48_RS11185	COG0492	ferredoxin-NADP+ reductase activity
KFV48_RS11200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFV48_RS11205	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFV48_RS11210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFV48_RS11215	COG0556	nucleotide-excision repair
KFV48_RS11230	COG1388	LysM domain
KFV48_RS11230	COG3942	CHAP domain
KFV48_RS11240	COG0653	protein targeting
KFV48_RS11245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFV48_RS11250	COG1040	competence protein
KFV48_RS11255	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KFV48_RS11265	COG1739	Uncharacterized protein family UPF0029
KFV48_RS11270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFV48_RS11275	COG2199	diguanylate cyclase activity
KFV48_RS11290	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFV48_RS11295	COG1929	Belongs to the glycerate kinase type-1 family
KFV48_RS11315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFV48_RS11330	COG4604	ABC transporter, ATP-binding protein
KFV48_RS11340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV48_RS11350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV48_RS11355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFV48_RS11360	COG1780	Probably involved in ribonucleotide reductase function
KFV48_RS11370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFV48_RS11375	COG3104	oligopeptide transport
KFV48_RS11385	COG1597	lipid kinase activity
KFV48_RS11390	COG1012	belongs to the aldehyde dehydrogenase family
KFV48_RS11390	COG1454	alcohol dehydrogenase
KFV48_RS11395	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
KFV48_RS11400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFV48_RS11405	COG1174	glycine betaine transport
KFV48_RS11415	COG0514	ATP-dependent DNA helicase (RecQ)
KFV48_RS11420	COG0488	(ABC) transporter
KFV48_RS11435	COG1368	sulfuric ester hydrolase activity
KFV48_RS11445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KFV48_RS11460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFV48_RS11470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFV48_RS11475	COG0720	synthase
KFV48_RS11480	COG0602	queuosine metabolic process
KFV48_RS11505	COG0745	RESPONSE REGULATOR receiver
KFV48_RS11510	COG5002	protein histidine kinase activity
KFV48_RS11515	COG0463	Glycosyl transferase, family 2
KFV48_RS11520	COG0656	L-ascorbic acid biosynthetic process
KFV48_RS11525	COG1253	flavin adenine dinucleotide binding
KFV48_RS11530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KFV48_RS11535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV48_RS11535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KFV48_RS11535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFV48_RS11540	COG1105	Belongs to the carbohydrate kinase PfkB family
KFV48_RS11545	COG1349	DNA-binding transcription factor activity
KFV48_RS11550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KFV48_RS11575	COG0415	Belongs to the DNA photolyase family
KFV48_RS11585	COG0471	metal ion transport
KFV48_RS11590	COG0039	L-malate dehydrogenase activity
KFV48_RS11610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KFV48_RS11615	COG4988	ABC transporter
KFV48_RS11620	COG1968	undecaprenyl-diphosphatase activity
KFV48_RS11635	COG1671	Belongs to the UPF0178 family
KFV48_RS11640	COG1611	Belongs to the LOG family
KFV48_RS11665	COG2839	Protein conserved in bacteria
KFV48_RS11670	COG2814	Major facilitator Superfamily
KFV48_RS11675	COG0583	DNA-binding transcription factor activity
KFV48_RS11695	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KFV48_RS11705	COG0217	transcriptional regulatory protein
KFV48_RS11725	COG1388	LysM domain
KFV48_RS11725	COG3942	CHAP domain
KFV48_RS11730	COG0306	phosphate transporter
KFV48_RS11735	COG1392	Phosphate transport regulator
KFV48_RS11740	COG0577	efflux transmembrane transporter activity
KFV48_RS11745	COG1136	(ABC) transporter
KFV48_RS11750	COG2205	protein histidine kinase activity
KFV48_RS11755	COG0745	RESPONSE REGULATOR receiver
KFV48_RS11760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFV48_RS11775	COG3949	Membrane
KFV48_RS11785	COG1120	ATPase activity
KFV48_RS11790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KFV48_RS11795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFV48_RS11805	COG1132	(ABC) transporter
KFV48_RS11810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KFV48_RS11820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS11825	COG1682	transport, permease protein
KFV48_RS11830	COG1134	teichoic acid transport
KFV48_RS11835	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KFV48_RS11845	COG1321	iron dependent repressor
KFV48_RS11850	COG1121	(ABC) transporter
KFV48_RS11855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFV48_RS11860	COG0803	Belongs to the bacterial solute-binding protein 9 family
KFV48_RS11870	COG1320	monovalent cation:proton antiporter activity
KFV48_RS11875	COG2212	antiporter activity
KFV48_RS11880	COG1863	multisubunit Na H antiporter MnhE subunit
KFV48_RS11885	COG0651	ATP synthesis coupled electron transport
KFV48_RS11890	COG1006	Multisubunit Na H antiporter MnhC subunit
KFV48_RS11895	COG2111	Na H antiporter
KFV48_RS11900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV48_RS11900	COG2111	Na H antiporter
KFV48_RS11930	COG0596	Alpha beta hydrolase
KFV48_RS11950	COG0546	phosphoglycolate phosphatase activity
KFV48_RS11955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFV48_RS11960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFV48_RS11970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFV48_RS11975	COG0018	arginyl-trna synthetase
KFV48_RS11990	COG1064	alcohol dehydrogenase
KFV48_RS11995	COG3875	lactate racemase activity
KFV48_RS12000	COG1606	tRNA processing
KFV48_RS12005	COG1691	(AIR) carboxylase
KFV48_RS12010	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KFV48_RS12020	COG1078	dGTPase activity
KFV48_RS12030	COG0667	Aldo Keto reductase
KFV48_RS12040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFV48_RS12045	COG4844	belongs to the
KFV48_RS12065	COG0095	Lipoate-protein ligase
KFV48_RS12070	COG0280	phosphate acetyltransferase
KFV48_RS12075	COG3253	May function as heme-dependent peroxidase
KFV48_RS12100	COG0531	amino acid
KFV48_RS12105	COG2363	Small membrane protein
KFV48_RS12115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFV48_RS12125	COG0351	phosphomethylpyrimidine kinase
KFV48_RS12145	COG0183	Belongs to the thiolase family
KFV48_RS12150	COG0318	PFAM AMP-dependent synthetase and ligase
KFV48_RS12165	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KFV48_RS12170	COG0363	glucosamine-6-phosphate deaminase activity
KFV48_RS12180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KFV48_RS12185	COG1469	GTP cyclohydrolase I activity
KFV48_RS12210	COG0431	NADPH-dependent FMN reductase
KFV48_RS12215	COG0561	phosphatase activity
KFV48_RS12225	COG1428	Deoxynucleoside kinase
KFV48_RS12230	COG1428	Deoxynucleoside kinase
KFV48_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
KFV48_RS12240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFV48_RS12245	COG0546	phosphoglycolate phosphatase activity
KFV48_RS12250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KFV48_RS12255	COG1063	alcohol dehydrogenase
KFV48_RS12260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFV48_RS12265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFV48_RS12270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFV48_RS12290	COG1473	amidohydrolase
KFV48_RS12295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFV48_RS12300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFV48_RS12310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFV48_RS12320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFV48_RS12325	COG0085	RNA polymerase activity
KFV48_RS12330	COG2813	Specifically methylates the guanine in position
KFV48_RS12335	COG0222	ribosome binding
KFV48_RS12340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFV48_RS12345	COG0081	regulation of translation
KFV48_RS12350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFV48_RS12355	COG0250	Participates in transcription elongation, termination and antitermination
KFV48_RS12360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFV48_RS12365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFV48_RS12375	COG3688	RNA-binding protein containing a PIN domain
KFV48_RS12380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFV48_RS12385	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KFV48_RS12390	COG0215	cysteine-tRNA ligase activity
KFV48_RS12395	COG1045	serine acetyltransferase
KFV48_RS12400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFV48_RS12405	COG4956	integral membrane protein (PIN domain superfamily)
KFV48_RS12410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFV48_RS12415	COG0542	response to heat
KFV48_RS12420	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KFV48_RS12425	COG3880	PFAM UvrB UvrC protein
KFV48_RS12430	COG4463	regulation of RNA biosynthetic process
KFV48_RS12435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFV48_RS12445	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KFV48_RS12450	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KFV48_RS12455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFV48_RS12525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFV48_RS12530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFV48_RS12535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFV48_RS12540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFV48_RS12545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFV48_RS12550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFV48_RS12555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFV48_RS12560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KFV48_RS12565	COG0037	tRNA processing
KFV48_RS12570	COG1098	S1 RNA binding domain
KFV48_RS12580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFV48_RS12585	COG3956	TIGRFAM MazG family protein
KFV48_RS12590	COG2244	polysaccharide biosynthetic process
KFV48_RS12595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFV48_RS12600	COG0193	aminoacyl-tRNA hydrolase activity
KFV48_RS12605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFV48_RS12610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFV48_RS12615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFV48_RS12620	COG2088	sporulation resulting in formation of a cellular spore
KFV48_RS12625	COG0251	oxidation-reduction process
KFV48_RS12630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV48_RS12635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFV48_RS12640	COG4466	Protein conserved in bacteria
KFV48_RS12645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFV48_RS12650	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KFV48_RS12655	COG0084	hydrolase, TatD family'
KFV48_RS12660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV48_RS12660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFV48_RS12665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFV48_RS12670	COG2827	Endonuclease containing a URI domain
KFV48_RS12675	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KFV48_RS12680	COG4467	Involved in initiation control of chromosome replication
KFV48_RS12685	COG1774	PSP1 C-terminal conserved region
KFV48_RS12690	COG0470	DNA polymerase III
KFV48_RS12695	COG3870	Protein conserved in bacteria
KFV48_RS12700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFV48_RS12705	COG1982	Orn Lys Arg decarboxylase major
KFV48_RS12730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFV48_RS12735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFV48_RS12740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFV48_RS12760	COG2855	membrane
KFV48_RS12765	COG0583	DNA-binding transcription factor activity
KFV48_RS12775	COG0493	'glutamate synthase
KFV48_RS12780	COG0067	glutamate synthase
KFV48_RS12780	COG0069	glutamate synthase activity
KFV48_RS12780	COG0070	glutamate synthase
KFV48_RS12785	COG0583	DNA-binding transcription factor activity
KFV48_RS12810	COG0438	transferase activity, transferring glycosyl groups
KFV48_RS12815	COG1388	LysM domain
KFV48_RS12815	COG3942	CHAP domain
KFV48_RS12825	COG2011	ABC-type metal ion transport system permease component
KFV48_RS12830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFV48_RS12835	COG0626	cystathionine gamma-synthase activity
KFV48_RS12840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFV48_RS12850	COG0733	neurotransmitter:sodium symporter activity
KFV48_RS12860	COG1647	Serine aminopeptidase, S33
KFV48_RS12875	COG5609	conserved protein (DUF2294)
KFV48_RS12880	COG3002	Belongs to the UPF0753 family
KFV48_RS12885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFV48_RS12905	COG0523	cobalamin synthesis protein
KFV48_RS12945	COG0519	Catalyzes the synthesis of GMP from XMP
KFV48_RS12945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFV48_RS12950	COG0516	GMP reductase activity
KFV48_RS12950	COG0517	IMP dehydrogenase activity
KFV48_RS12955	COG2233	PERMEase
KFV48_RS12960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFV48_RS12975	COG5183	chlorophyll binding
KFV48_RS12980	COG1823	symporter activity
KFV48_RS12985	COG0778	Nitroreductase
KFV48_RS12995	COG0450	alkyl hydroperoxide reductase
KFV48_RS13000	COG3634	alkyl hydroperoxide reductase activity
KFV48_RS13020	COG1280	lysine exporter protein (LysE YggA)
KFV48_RS13035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFV48_RS13045	COG0360	Binds together with S18 to 16S ribosomal RNA
KFV48_RS13060	COG0012	GTP binding
KFV48_RS13065	COG4481	Protein conserved in bacteria
KFV48_RS13070	COG0668	transmembrane transport
KFV48_RS13075	COG1475	DNA binding
KFV48_RS13080	COG0626	cystathionine gamma-synthase activity
KFV48_RS13085	COG0626	cystathionine gamma-synthase activity
KFV48_RS13090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KFV48_RS13090	COG0646	methionine synthase
KFV48_RS13095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFV48_RS13105	COG0183	Belongs to the thiolase family
KFV48_RS13120	COG1476	TRANSCRIPTIONal
KFV48_RS13160	COG1136	(ABC) transporter
KFV48_RS13165	COG0577	efflux transmembrane transporter activity
KFV48_RS13180	COG0577	efflux transmembrane transporter activity
KFV48_RS13185	COG1136	(ABC) transporter
KFV48_RS13220	COG1475	DNA binding
KFV48_RS13225	COG0357	Ribosomal RNA small subunit methyltransferase G
KFV48_RS13230	COG0445	tRNA wobble uridine modification
KFV48_RS13235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFV48_RS13240	COG0594	ribonuclease P activity
KFV48_RS13250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFV48_RS13445	COG2314	TM2 domain