locus-tag	class	description
M8Z30_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M8Z30_RS00010	COG0592	DNA-directed DNA polymerase activity
M8Z30_RS00015	COG2501	S4 domain
M8Z30_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M8Z30_RS00025	COG0187	DNA topoisomerase II activity
M8Z30_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8Z30_RS00045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M8Z30_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M8Z30_RS00070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M8Z30_RS00080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M8Z30_RS00085	COG0359	binds to the 23S rRNA
M8Z30_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
M8Z30_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M8Z30_RS00110	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS00115	COG5002	protein histidine kinase activity
M8Z30_RS00120	COG4863	YycH protein
M8Z30_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M8Z30_RS00135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M8Z30_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
M8Z30_RS00160	COG2030	dehydratase
M8Z30_RS00235	COG1396	sequence-specific DNA binding
M8Z30_RS00255	COG2113	Glycine betaine
M8Z30_RS00260	COG2409	Drug exporters of the RND superfamily
M8Z30_RS00290	COG2217	Heavy metal translocating P-type atpase
M8Z30_RS00295	COG2132	Multicopper oxidase
M8Z30_RS00300	COG1388	LysM domain
M8Z30_RS00305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8Z30_RS00310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M8Z30_RS00330	COG0640	Transcriptional regulator
M8Z30_RS00350	COG0668	transmembrane transport
M8Z30_RS00355	COG0561	phosphatase activity
M8Z30_RS00385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M8Z30_RS00390	COG0579	oxidoreductase
M8Z30_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS00405	COG1755	Isoprenylcysteine carboxyl methyltransferase
M8Z30_RS00415	COG4753	response regulator
M8Z30_RS00415	COG2207	Transcriptional regulator
M8Z30_RS00445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8Z30_RS00445	COG4932	domain protein
M8Z30_RS00445	COG3583	domain protein
M8Z30_RS00445	COG4932	domain protein
M8Z30_RS00445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M8Z30_RS00445	COG3583	domain protein
M8Z30_RS00455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M8Z30_RS00460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M8Z30_RS00465	COG0156	8-amino-7-oxononanoate synthase activity
M8Z30_RS00470	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
M8Z30_RS00495	COG0523	cobalamin synthesis protein
M8Z30_RS00510	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8Z30_RS00520	COG0431	NADPH-dependent FMN reductase
M8Z30_RS00520	COG1053	succinate dehydrogenase
M8Z30_RS00520	COG3976	FMN-binding domain protein
M8Z30_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS00535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M8Z30_RS00565	COG0601	transmembrane transport
M8Z30_RS00575	COG0444	Belongs to the ABC transporter superfamily
M8Z30_RS00580	COG1124	(ABC) transporter
M8Z30_RS00590	COG1882	Formate acetyltransferase
M8Z30_RS00595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M8Z30_RS00600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8Z30_RS00605	COG1114	Component of the transport system for branched-chain amino acids
M8Z30_RS00610	COG1309	transcriptional regulator
M8Z30_RS00615	COG3246	L-lysine catabolic process to acetate
M8Z30_RS00620	COG1250	3-hydroxyacyl-CoA dehydrogenase
M8Z30_RS00655	COG1288	antiporter activity
M8Z30_RS00660	COG0549	Belongs to the carbamate kinase family
M8Z30_RS00665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8Z30_RS00680	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M8Z30_RS00685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M8Z30_RS00695	COG2376	Dihydroxyacetone kinase
M8Z30_RS00700	COG1461	Dihydroxyacetone kinase
M8Z30_RS00705	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M8Z30_RS00720	COG2814	Major facilitator Superfamily
M8Z30_RS00750	COG2814	Major facilitator Superfamily
M8Z30_RS00765	COG2962	Rard protein
M8Z30_RS00770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M8Z30_RS00775	COG0471	metal ion transport
M8Z30_RS00785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8Z30_RS00790	COG0022	dehydrogenase e1 component
M8Z30_RS00795	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8Z30_RS00820	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M8Z30_RS00825	COG1054	Belongs to the UPF0176 family
M8Z30_RS00830	COG3386	PFAM SMP-30 Gluconolaconase
M8Z30_RS00835	COG2353	YceI-like domain
M8Z30_RS00840	COG0579	oxidoreductase
M8Z30_RS00865	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M8Z30_RS00870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M8Z30_RS00875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M8Z30_RS00880	COG0131	Imidazoleglycerol-phosphate dehydratase
M8Z30_RS00885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M8Z30_RS00890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M8Z30_RS00895	COG0107	imidazoleglycerol-phosphate synthase activity
M8Z30_RS00900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M8Z30_RS00900	COG0140	phosphoribosyl-ATP diphosphatase activity
M8Z30_RS00905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M8Z30_RS00910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M8Z30_RS00920	COG0726	polysaccharide deacetylase
M8Z30_RS00945	COG2814	Major facilitator Superfamily
M8Z30_RS00950	COG0737	Belongs to the 5'-nucleotidase family
M8Z30_RS00965	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M8Z30_RS00990	COG0201	protein transport
M8Z30_RS01000	COG1073	alpha beta
M8Z30_RS01010	COG0653	protein targeting
M8Z30_RS01015	COG0438	transferase activity, transferring glycosyl groups
M8Z30_RS01040	COG2814	Major facilitator Superfamily
M8Z30_RS01045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8Z30_RS01060	COG1764	response to oxidative stress
M8Z30_RS01070	COG1705	Flagellar rod assembly protein muramidase FlgJ
M8Z30_RS01070	COG3942	CHAP domain
M8Z30_RS01080	COG1482	cell wall glycoprotein biosynthetic process
M8Z30_RS01085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8Z30_RS01085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8Z30_RS01085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8Z30_RS01090	COG3711	transcriptional antiterminator
M8Z30_RS01090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8Z30_RS01125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8Z30_RS01130	COG3227	Zinc metalloprotease (Elastase)
M8Z30_RS01135	COG1438	arginine binding
M8Z30_RS01140	COG2235	arginine
M8Z30_RS01145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M8Z30_RS01155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M8Z30_RS01165	COG2843	Capsule synthesis protein
M8Z30_RS01170	COG3961	Belongs to the TPP enzyme family
M8Z30_RS01195	COG1196	nuclear chromosome segregation
M8Z30_RS01205	COG4195	phage-related replication protein
M8Z30_RS01220	COG0702	epimerase
M8Z30_RS01225	COG1785	Belongs to the alkaline phosphatase family
M8Z30_RS01240	COG2205	protein histidine kinase activity
M8Z30_RS01245	COG1136	(ABC) transporter
M8Z30_RS01260	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8Z30_RS01285	COG1846	Transcriptional regulator
M8Z30_RS01295	COG0386	Belongs to the glutathione peroxidase family
M8Z30_RS01300	COG0175	sulfate reduction
M8Z30_RS01305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M8Z30_RS01310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8Z30_RS01325	COG0730	response to heat
M8Z30_RS01330	COG2046	Belongs to the sulfate adenylyltransferase family
M8Z30_RS01335	COG0529	Catalyzes the synthesis of activated sulfate
M8Z30_RS01345	COG1328	CTP reductase activity
M8Z30_RS01350	COG0602	queuosine metabolic process
M8Z30_RS01355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M8Z30_RS01365	COG1510	regulation of RNA biosynthetic process
M8Z30_RS01370	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS01375	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M8Z30_RS01380	COG1473	amidohydrolase
M8Z30_RS01395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M8Z30_RS01400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8Z30_RS01400	COG0574	Belongs to the PEP-utilizing enzyme family
M8Z30_RS01405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M8Z30_RS01410	COG0579	oxidoreductase
M8Z30_RS01420	COG3588	fructose-bisphosphate aldolase
M8Z30_RS01425	COG0446	pyridine nucleotide-disulphide oxidoreductase
M8Z30_RS01455	COG0531	amino acid
M8Z30_RS01460	COG0583	DNA-binding transcription factor activity
M8Z30_RS01465	COG0039	L-malate dehydrogenase activity
M8Z30_RS01470	COG0028	Belongs to the TPP enzyme family
M8Z30_RS01475	COG3527	Alpha-acetolactate decarboxylase
M8Z30_RS01485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M8Z30_RS01490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M8Z30_RS01495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M8Z30_RS01510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8Z30_RS01525	COG0167	dihydroorotate dehydrogenase activity
M8Z30_RS01530	COG3001	Fructosamine kinase
M8Z30_RS01535	COG1113	amino acid transport
M8Z30_RS01550	COG0741	lytic transglycosylase activity
M8Z30_RS01560	COG3942	CHAP domain
M8Z30_RS01565	COG0436	Aminotransferase
M8Z30_RS01575	COG2608	mercury ion transmembrane transporter activity
M8Z30_RS01580	COG2217	Heavy metal translocating P-type atpase
M8Z30_RS01590	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS01595	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS01620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M8Z30_RS01625	COG3425	synthase
M8Z30_RS01645	COG0583	DNA-binding transcription factor activity
M8Z30_RS01650	COG1380	Effector of murein hydrolase LrgA
M8Z30_RS01655	COG1346	cytolysis
M8Z30_RS01660	COG0028	Belongs to the TPP enzyme family
M8Z30_RS01665	COG1263	PTS System
M8Z30_RS01665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8Z30_RS01665	COG2190	(PTS) system
M8Z30_RS01680	COG1063	alcohol dehydrogenase
M8Z30_RS01690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8Z30_RS01705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8Z30_RS01715	COG2843	Capsule synthesis protein
M8Z30_RS01730	COG4975	Glucose uptake
M8Z30_RS01735	COG1869	D-ribose catabolic process
M8Z30_RS01745	COG1070	Carbohydrate kinase
M8Z30_RS01760	COG1760	l-serine dehydratase
M8Z30_RS01765	COG1760	l-serine dehydratase
M8Z30_RS01790	COG3764	Sortase (surface protein transpeptidase)
M8Z30_RS01800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8Z30_RS01805	COG0778	Nitroreductase
M8Z30_RS01810	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS01820	COG2514	catechol 2,3-dioxygenase activity
M8Z30_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS01840	COG3949	Membrane
M8Z30_RS01850	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M8Z30_RS01855	COG0586	Pfam SNARE associated Golgi protein
M8Z30_RS01860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8Z30_RS01865	COG2022	thiamine diphosphate biosynthetic process
M8Z30_RS01875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M8Z30_RS01900	COG4876	unkown
M8Z30_RS01905	COG2357	RelA SpoT domain protein
M8Z30_RS01920	COG0789	Transcriptional regulator
M8Z30_RS01925	COG2271	Major facilitator Superfamily
M8Z30_RS01930	COG1802	Transcriptional regulator
M8Z30_RS01940	COG2610	gluconate transmembrane transporter activity
M8Z30_RS01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M8Z30_RS01950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8Z30_RS01960	COG0438	transferase activity, transferring glycosyl groups
M8Z30_RS01965	COG0494	nUDIX hydrolase
M8Z30_RS01970	COG0556	nucleotide-excision repair
M8Z30_RS01985	COG4221	oxidoreductase activity
M8Z30_RS01990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8Z30_RS01995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M8Z30_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS02015	COG1363	Peptidase, m42
M8Z30_RS02025	COG0069	glutamate synthase activity
M8Z30_RS02040	COG4619	ABC transporter
M8Z30_RS02045	COG0390	transport system, permease component
M8Z30_RS02050	COG2814	Major facilitator Superfamily
M8Z30_RS02055	COG2272	Belongs to the type-B carboxylesterase lipase family
M8Z30_RS02060	COG0531	amino acid
M8Z30_RS02070	COG1063	alcohol dehydrogenase
M8Z30_RS02090	COG1174	glycine betaine transport
M8Z30_RS02095	COG1346	cytolysis
M8Z30_RS02100	COG1380	Effector of murein hydrolase LrgA
M8Z30_RS02105	COG3279	Response regulator of the LytR AlgR family
M8Z30_RS02110	COG3275	phosphorelay sensor kinase activity
M8Z30_RS02125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M8Z30_RS02130	COG0706	membrane insertase activity
M8Z30_RS02140	COG0531	amino acid
M8Z30_RS02145	COG1113	amino acid transport
M8Z30_RS02170	COG1929	Belongs to the glycerate kinase type-1 family
M8Z30_RS02185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M8Z30_RS02190	COG0588	phosphoglycerate mutase activity
M8Z30_RS02200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M8Z30_RS02205	COG0765	amino acid transport
M8Z30_RS02210	COG1126	abc transporter atp-binding protein
M8Z30_RS02220	COG2348	transferase activity, transferring amino-acyl groups
M8Z30_RS02245	COG0454	-acetyltransferase
M8Z30_RS02255	COG0747	negative chemotaxis
M8Z30_RS02265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M8Z30_RS02270	COG2146	nitrite reductase [NAD(P)H] activity
M8Z30_RS02280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M8Z30_RS02285	COG1140	nitrate reductase beta subunit
M8Z30_RS02295	COG2181	nitrate reductase activity
M8Z30_RS02305	COG4585	Histidine kinase
M8Z30_RS02310	COG2197	response regulator
M8Z30_RS02315	COG2223	nitrite transmembrane transporter activity
M8Z30_RS02320	COG1846	Transcriptional regulator
M8Z30_RS02325	COG0778	Nitroreductase
M8Z30_RS02345	COG3871	stress protein (general stress protein 26)
M8Z30_RS02360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8Z30_RS02360	COG1263	PTS System
M8Z30_RS02400	COG0604	alcohol dehydrogenase
M8Z30_RS02405	COG0456	acetyltransferase
M8Z30_RS02410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8Z30_RS02410	COG0463	Glycosyl transferase, family 2
M8Z30_RS02420	COG0463	Glycosyl transferase, family 2
M8Z30_RS02420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8Z30_RS02425	COG1620	l-lactate permease
M8Z30_RS02430	COG0438	transferase activity, transferring glycosyl groups
M8Z30_RS02435	COG0579	oxidoreductase
M8Z30_RS02440	COG5002	protein histidine kinase activity
M8Z30_RS02440	COG3850	Histidine kinase
M8Z30_RS02445	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS02450	COG0577	efflux transmembrane transporter activity
M8Z30_RS02455	COG1136	(ABC) transporter
M8Z30_RS02470	COG4640	response to antibiotic
M8Z30_RS02475	COG2814	Major facilitator Superfamily
M8Z30_RS02485	COG1566	PFAM secretion protein HlyD family protein
M8Z30_RS02490	COG2814	Major facilitator Superfamily
M8Z30_RS02500	COG0657	acetylesterase activity
M8Z30_RS02515	COG0598	Magnesium transport protein CorA
M8Z30_RS02520	COG1304	FMN binding
M8Z30_RS02525	COG0786	glutamate:sodium symporter activity
M8Z30_RS02545	COG2094	Belongs to the DNA glycosylase MPG family
M8Z30_RS02555	COG1069	ribulokinase activity
M8Z30_RS02560	COG2017	converts alpha-aldose to the beta-anomer
M8Z30_RS02565	COG2258	MOSC domain
M8Z30_RS02570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M8Z30_RS02580	COG1266	CAAX protease self-immunity
M8Z30_RS02585	COG0010	Belongs to the arginase family
M8Z30_RS02590	COG1473	amidohydrolase
M8Z30_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS02600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M8Z30_RS02635	COG1737	Transcriptional regulator
M8Z30_RS02640	COG1263	PTS System
M8Z30_RS02640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8Z30_RS02650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M8Z30_RS02670	COG1113	amino acid transport
M8Z30_RS02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8Z30_RS02680	COG1263	PTS System
M8Z30_RS02685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M8Z30_RS02700	COG1266	CAAX protease self-immunity
M8Z30_RS02705	COG2378	regulation of single-species biofilm formation
M8Z30_RS02710	COG0483	inositol monophosphate 1-phosphatase activity
M8Z30_RS02715	COG1316	TRANSCRIPTIONal
M8Z30_RS02735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8Z30_RS02740	COG2076	Multidrug Resistance protein
M8Z30_RS02745	COG2076	Multidrug Resistance protein
M8Z30_RS02750	COG3942	CHAP domain
M8Z30_RS02765	COG1757	Na H antiporter
M8Z30_RS02770	COG3942	CHAP domain
M8Z30_RS02795	COG0829	nickel cation binding
M8Z30_RS02800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M8Z30_RS02805	COG0830	nickel cation binding
M8Z30_RS02810	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M8Z30_RS02815	COG0804	urea catabolic process
M8Z30_RS02820	COG0832	Belongs to the urease beta subunit family
M8Z30_RS02825	COG0831	urea catabolic process
M8Z30_RS02835	COG1960	acyl-CoA dehydrogenase activity
M8Z30_RS02845	COG1268	BioY protein
M8Z30_RS02860	COG0725	ABC transporter, periplasmic molybdate-binding protein
M8Z30_RS02865	COG4149	molybdate abc transporter
M8Z30_RS02870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M8Z30_RS02875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M8Z30_RS02880	COG0521	Mo-molybdopterin cofactor biosynthetic process
M8Z30_RS02885	COG0315	cyclic pyranopterin monophosphate synthase activity
M8Z30_RS02890	COG0303	'Molybdopterin
M8Z30_RS02900	COG0314	molybdopterin synthase activity
M8Z30_RS02910	COG0746	molybdenum cofactor guanylyltransferase activity
M8Z30_RS02915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M8Z30_RS02940	COG2814	Major facilitator Superfamily
M8Z30_RS02960	COG2348	transferase activity, transferring amino-acyl groups
M8Z30_RS02965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M8Z30_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS02990	COG4975	Glucose uptake
M8Z30_RS02995	COG0551	DNA topoisomerase type I activity
M8Z30_RS02995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8Z30_RS03000	COG2252	PERMEase
M8Z30_RS03015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M8Z30_RS03020	COG0088	Forms part of the polypeptide exit tunnel
M8Z30_RS03025	COG0089	rRNA binding
M8Z30_RS03030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M8Z30_RS03035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M8Z30_RS03040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M8Z30_RS03045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M8Z30_RS03050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M8Z30_RS03060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M8Z30_RS03065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M8Z30_RS03070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M8Z30_RS03075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M8Z30_RS03080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M8Z30_RS03085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M8Z30_RS03090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M8Z30_RS03095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M8Z30_RS03100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M8Z30_RS03105	COG1841	ribosomal large subunit assembly
M8Z30_RS03110	COG0200	Binds to the 23S rRNA
M8Z30_RS03115	COG0201	protein transport
M8Z30_RS03120	COG0563	adenylate kinase activity
M8Z30_RS03125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M8Z30_RS03130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M8Z30_RS03135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M8Z30_RS03140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M8Z30_RS03145	COG0202	RNA polymerase activity
M8Z30_RS03150	COG0203	ribosomal protein L17
M8Z30_RS03155	COG1122	ATPase activity
M8Z30_RS03160	COG1122	ATPase activity
M8Z30_RS03170	COG0101	tRNA pseudouridine synthase activity
M8Z30_RS03175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M8Z30_RS03180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M8Z30_RS03185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M8Z30_RS03190	COG1349	DNA-binding transcription factor activity
M8Z30_RS03195	COG0698	ribose 5-phosphate isomerase
M8Z30_RS03200	COG0698	ribose 5-phosphate isomerase
M8Z30_RS03205	COG1105	Belongs to the carbohydrate kinase PfkB family
M8Z30_RS03210	COG3684	Belongs to the aldolase LacD family
M8Z30_RS03215	COG1447	Phosphotransferase system cellobiose-specific component IIA
M8Z30_RS03220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8Z30_RS03220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M8Z30_RS03225	COG2723	6-phospho-beta-galactosidase activity
M8Z30_RS03235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8Z30_RS03240	COG2130	NADP-dependent
M8Z30_RS03245	COG0604	alcohol dehydrogenase
M8Z30_RS03260	COG1302	Protein conserved in bacteria
M8Z30_RS03265	COG4264	IucA IucC family
M8Z30_RS03270	COG2814	Major facilitator Superfamily
M8Z30_RS03275	COG4264	IucA IucC family
M8Z30_RS03280	COG3457	Alanine racemase
M8Z30_RS03285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M8Z30_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8Z30_RS03295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8Z30_RS03405	COG3682	Transcriptional regulator
M8Z30_RS03480	COG0456	acetyltransferase
M8Z30_RS03495	COG1682	transport, permease protein
M8Z30_RS03530	COG3314	Sporulation integral membrane protein YlbJ
M8Z30_RS03535	COG2329	Antibiotic biosynthesis monooxygenase
M8Z30_RS03545	COG1988	membrane-bound metal-dependent
M8Z30_RS03550	COG4284	Utp--glucose-1-phosphate uridylyltransferase
M8Z30_RS03570	COG2814	Major facilitator Superfamily
M8Z30_RS03575	COG0489	protein tyrosine kinase activity
M8Z30_RS03625	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M8Z30_RS03635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M8Z30_RS03640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M8Z30_RS03645	COG0561	phosphatase activity
M8Z30_RS03665	COG0640	Transcriptional regulator
M8Z30_RS03670	COG0702	epimerase
M8Z30_RS03675	COG1482	cell wall glycoprotein biosynthetic process
M8Z30_RS03695	COG0783	Belongs to the Dps family
M8Z30_RS03700	COG0813	purine-nucleoside phosphorylase activity
M8Z30_RS03705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M8Z30_RS03710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M8Z30_RS03715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M8Z30_RS03725	COG1854	S-ribosylhomocysteine lyase activity
M8Z30_RS03745	COG5146	pantothenate kinase activity
M8Z30_RS03755	COG3343	RNA polymerase activity
M8Z30_RS03760	COG0504	CTP synthase activity
M8Z30_RS03770	COG0191	fructose-bisphosphate aldolase activity
M8Z30_RS03775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8Z30_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS03785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M8Z30_RS03790	COG0254	rRNA binding
M8Z30_RS03795	COG1435	thymidine kinase activity
M8Z30_RS03800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M8Z30_RS03805	COG2890	protein-(glutamine-N5) methyltransferase activity
M8Z30_RS03810	COG0009	L-threonylcarbamoyladenylate synthase
M8Z30_RS03815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8Z30_RS03820	COG4475	Protein of unknown function (DUF436)
M8Z30_RS03825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M8Z30_RS03830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M8Z30_RS03835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M8Z30_RS03845	COG0356	it plays a direct role in the translocation of protons across the membrane
M8Z30_RS03855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M8Z30_RS03860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M8Z30_RS03865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M8Z30_RS03870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M8Z30_RS03875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M8Z30_RS03880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M8Z30_RS03890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M8Z30_RS03895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M8Z30_RS03905	COG0629	single-stranded DNA binding
M8Z30_RS03910	COG1388	LysM domain
M8Z30_RS03915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M8Z30_RS03925	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M8Z30_RS03930	COG0352	thiamine-phosphate diphosphorylase activity
M8Z30_RS03935	COG0706	membrane insertase activity
M8Z30_RS03940	COG1418	mRNA catabolic process
M8Z30_RS03945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8Z30_RS03950	COG1937	Protein conserved in bacteria
M8Z30_RS03965	COG0772	Belongs to the SEDS family
M8Z30_RS03970	COG1181	Belongs to the D-alanine--D-alanine ligase family
M8Z30_RS03975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M8Z30_RS03980	COG0513	Belongs to the DEAD box helicase family
M8Z30_RS03990	COG3428	Bacterial PH domain
M8Z30_RS03995	COG3402	PFAM membrane-flanked domain
M8Z30_RS04000	COG0736	holo-[acyl-carrier-protein] synthase activity
M8Z30_RS04005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M8Z30_RS04015	COG2337	Toxic component of a toxin-antitoxin (TA) module
M8Z30_RS04020	COG2208	phosphoserine phosphatase activity
M8Z30_RS04035	COG1191	sigma factor activity
M8Z30_RS04040	COG2183	response to ionizing radiation
M8Z30_RS04045	COG3091	SprT-like family
M8Z30_RS04075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M8Z30_RS04080	COG0066	3-isopropylmalate dehydratase activity
M8Z30_RS04085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M8Z30_RS04090	COG0473	3-isopropylmalate dehydrogenase activity
M8Z30_RS04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M8Z30_RS04100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M8Z30_RS04110	COG0028	Belongs to the TPP enzyme family
M8Z30_RS04115	COG0129	dihydroxy-acid dehydratase activity
M8Z30_RS04120	COG0802	atpase or kinase
M8Z30_RS04125	COG1214	PFAM Peptidase M22, glycoprotease
M8Z30_RS04130	COG0456	acetyltransferase
M8Z30_RS04135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M8Z30_RS04140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M8Z30_RS04145	COG0488	(ABC) transporter
M8Z30_RS04150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M8Z30_RS04160	COG2391	methyltransferase activity
M8Z30_RS04165	COG0425	Belongs to the sulfur carrier protein TusA family
M8Z30_RS04170	COG0004	ammonium transporteR
M8Z30_RS04175	COG1609	Transcriptional regulator
M8Z30_RS04180	COG1621	beta-fructofuranosidase activity
M8Z30_RS04185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M8Z30_RS04190	COG3279	Response regulator of the LytR AlgR family
M8Z30_RS04235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M8Z30_RS04240	COG0459	protein refolding
M8Z30_RS04245	COG0582	viral genome integration into host DNA
M8Z30_RS04260	COG3617	BRO family, N-terminal domain
M8Z30_RS04385	COG1725	Transcriptional regulator
M8Z30_RS04390	COG1131	(ABC) transporter
M8Z30_RS04400	COG1131	(ABC) transporter
M8Z30_RS04450	COG4974	Belongs to the 'phage' integrase family
M8Z30_RS04480	COG3682	Transcriptional regulator
M8Z30_RS04490	COG2706	6-phosphogluconolactonase activity
M8Z30_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS04500	COG1227	inorganic diphosphatase activity
M8Z30_RS04505	COG1335	isochorismatase
M8Z30_RS04515	COG0077	Prephenate dehydratase
M8Z30_RS04525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M8Z30_RS04530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M8Z30_RS04535	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M8Z30_RS04545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M8Z30_RS04550	COG4496	protein, YerC YecD
M8Z30_RS04555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M8Z30_RS04560	COG0210	DNA helicase
M8Z30_RS04565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M8Z30_RS04570	COG4851	CamS sex pheromone cAM373 precursor
M8Z30_RS04575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M8Z30_RS04580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M8Z30_RS04585	COG0154	amidase activity
M8Z30_RS04590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M8Z30_RS04595	COG1597	lipid kinase activity
M8Z30_RS04600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M8Z30_RS04610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8Z30_RS04620	COG1528	Iron-storage protein
M8Z30_RS04640	COG4129	membrane
M8Z30_RS04645	COG0024	Methionine aminopeptidase
M8Z30_RS04660	COG4585	Histidine kinase
M8Z30_RS04665	COG2197	response regulator
M8Z30_RS04670	COG1295	ribonuclease BN
M8Z30_RS04680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M8Z30_RS04685	COG4840	Belongs to the UPF0435 family
M8Z30_RS04690	COG2309	aminopeptidase activity
M8Z30_RS04695	COG1607	acyl-coa hydrolase
M8Z30_RS04700	COG0535	radical SAM domain protein
M8Z30_RS04710	COG0693	protein deglycase activity
M8Z30_RS04715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8Z30_RS04720	COG2137	regulation of response to DNA damage stimulus
M8Z30_RS04730	COG1134	teichoic acid transport
M8Z30_RS04730	COG1388	LysM domain
M8Z30_RS04740	COG1988	membrane-bound metal-dependent
M8Z30_RS04750	COG3557	Belongs to the UPF0374 family
M8Z30_RS04760	COG4129	membrane
M8Z30_RS04765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M8Z30_RS04770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M8Z30_RS04775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8Z30_RS04780	COG0735	belongs to the Fur family
M8Z30_RS05055	COG1595	DNA-templated transcription, initiation
M8Z30_RS05155	COG4824	toxin secretion phage lysis holin
M8Z30_RS05185	COG0765	amino acid transport
M8Z30_RS05190	COG1126	abc transporter atp-binding protein
M8Z30_RS05200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M8Z30_RS05225	COG0114	fumarate hydratase activity
M8Z30_RS05230	COG0564	pseudouridine synthase activity
M8Z30_RS05235	COG2203	Gaf domain
M8Z30_RS05235	COG4585	Histidine kinase
M8Z30_RS05240	COG2197	response regulator
M8Z30_RS05250	COG4399	Belongs to the UPF0754 family
M8Z30_RS05255	COG3679	Belongs to the UPF0342 family
M8Z30_RS05260	COG0420	3'-5' exonuclease activity
M8Z30_RS05270	COG3481	metal-dependent phosphohydrolase, HD sub domain
M8Z30_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M8Z30_RS05295	COG0537	adenosine 5'-monophosphoramidase activity
M8Z30_RS05300	COG1131	(ABC) transporter
M8Z30_RS05305	COG4473	ABC transporter
M8Z30_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
M8Z30_RS05320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M8Z30_RS05325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M8Z30_RS05330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M8Z30_RS05480	COG3942	CHAP domain
M8Z30_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
M8Z30_RS05590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M8Z30_RS05595	COG0494	nUDIX hydrolase
M8Z30_RS05600	COG1506	peptidase
M8Z30_RS05605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M8Z30_RS05610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M8Z30_RS05620	COG0656	L-ascorbic acid biosynthetic process
M8Z30_RS05635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8Z30_RS05640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M8Z30_RS05650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M8Z30_RS05675	COG4193	domain, Protein
M8Z30_RS05675	COG5632	N-Acetylmuramoyl-L-alanine amidase
M8Z30_RS05675	COG3266	domain, Protein
M8Z30_RS05685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8Z30_RS05685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M8Z30_RS05695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M8Z30_RS05695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M8Z30_RS05700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M8Z30_RS05705	COG0506	proline dehydrogenase activity
M8Z30_RS05710	COG2267	carboxylic ester hydrolase activity
M8Z30_RS05720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M8Z30_RS05725	COG1242	4 iron, 4 sulfur cluster binding
M8Z30_RS05730	COG2814	Major facilitator Superfamily
M8Z30_RS05735	COG0495	leucyl-tRNA aminoacylation
M8Z30_RS05750	COG2081	HI0933 family
M8Z30_RS05755	COG2244	polysaccharide biosynthetic process
M8Z30_RS05760	COG1187	pseudouridine synthase activity
M8Z30_RS05770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M8Z30_RS05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8Z30_RS05780	COG0510	thiamine kinase activity
M8Z30_RS05785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M8Z30_RS05795	COG1363	Peptidase, m42
M8Z30_RS05800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8Z30_RS05805	COG4848	Belongs to the UPF0354 family
M8Z30_RS05810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8Z30_RS05815	COG1674	ftsk spoiiie
M8Z30_RS05820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M8Z30_RS05825	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M8Z30_RS05835	COG1605	Chorismate mutase
M8Z30_RS05835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M8Z30_RS05840	COG1609	Transcriptional regulator
M8Z30_RS05845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M8Z30_RS05855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M8Z30_RS05860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8Z30_RS05865	COG0204	Acyl-transferase
M8Z30_RS05870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M8Z30_RS05870	COG1263	PTS System
M8Z30_RS05880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M8Z30_RS05885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M8Z30_RS05890	COG1764	response to oxidative stress
M8Z30_RS05895	COG0584	glycerophosphoryl diester phosphodiesterase
M8Z30_RS05900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M8Z30_RS05905	COG1956	GAF domain-containing protein
M8Z30_RS05910	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M8Z30_RS05920	COG0301	tRNA thio-modification
M8Z30_RS05930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M8Z30_RS05935	COG0827	DNA restriction-modification system
M8Z30_RS05940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M8Z30_RS05945	COG0589	response to stress
M8Z30_RS05950	COG0686	Belongs to the AlaDH PNT family
M8Z30_RS05955	COG0006	proline dipeptidase activity
M8Z30_RS05960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M8Z30_RS05970	COG4109	DRTGG domain
M8Z30_RS05975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M8Z30_RS05980	COG0587	DNA-directed DNA polymerase activity
M8Z30_RS05985	COG0281	malic enzyme
M8Z30_RS05990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M8Z30_RS05995	COG0825	malonyl-CoA metabolic process
M8Z30_RS06000	COG0205	6-phosphofructokinase activity
M8Z30_RS06005	COG0469	pyruvate kinase activity
M8Z30_RS06010	COG1113	amino acid transport
M8Z30_RS06015	COG0372	Belongs to the citrate synthase family
M8Z30_RS06020	COG0538	isocitrate dehydrogenase activity
M8Z30_RS06025	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS06030	COG5002	protein histidine kinase activity
M8Z30_RS06035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8Z30_RS06035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8Z30_RS06040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M8Z30_RS06045	COG0237	dephospho-CoA kinase activity
M8Z30_RS06055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8Z30_RS06060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M8Z30_RS06065	COG3611	Membrane attachment protein
M8Z30_RS06070	COG1484	DNA-dependent DNA replication
M8Z30_RS06075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M8Z30_RS06080	COG0833	amino acid
M8Z30_RS06085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M8Z30_RS06090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M8Z30_RS06095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M8Z30_RS06100	COG4112	unkown
M8Z30_RS06110	COG0544	peptidyl-prolyl cis-trans isomerase activity
M8Z30_RS06115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M8Z30_RS06120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M8Z30_RS06125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M8Z30_RS06135	COG0181	hydroxymethylbilane synthase activity
M8Z30_RS06145	COG0113	porphobilinogen synthase activity
M8Z30_RS06150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M8Z30_RS06160	COG2818	Glycosylase
M8Z30_RS06165	COG0525	valine-tRNA ligase activity
M8Z30_RS06170	COG0285	dihydrofolate synthase activity
M8Z30_RS06180	COG2003	Belongs to the UPF0758 family
M8Z30_RS06210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M8Z30_RS06215	COG2868	ribosomal protein
M8Z30_RS06220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M8Z30_RS06225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M8Z30_RS06230	COG4492	Belongs to the UPF0735 family
M8Z30_RS06235	COG0632	four-way junction helicase activity
M8Z30_RS06240	COG2255	four-way junction helicase activity
M8Z30_RS06245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M8Z30_RS06250	COG0343	queuine tRNA-ribosyltransferase activity
M8Z30_RS06255	COG1862	Preprotein translocase
M8Z30_RS06260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8Z30_RS06260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M8Z30_RS06265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M8Z30_RS06265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M8Z30_RS06270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8Z30_RS06275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M8Z30_RS06280	COG1490	D-aminoacyl-tRNA deacylase activity
M8Z30_RS06285	COG0860	N-Acetylmuramoyl-L-alanine amidase
M8Z30_RS06290	COG0124	histidyl-tRNA synthetase
M8Z30_RS06295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M8Z30_RS06305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M8Z30_RS06310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M8Z30_RS06315	COG1959	2 iron, 2 sulfur cluster binding
M8Z30_RS06325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8Z30_RS06330	COG1104	cysteine desulfurase activity
M8Z30_RS06335	COG0482	sulfurtransferase activity
M8Z30_RS06345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M8Z30_RS06350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M8Z30_RS06355	COG4472	Bacterial protein of unknown function (DUF965)
M8Z30_RS06360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M8Z30_RS06365	COG3906	Belongs to the UPF0473 family
M8Z30_RS06375	COG0826	peptidase U32
M8Z30_RS06380	COG0826	peptidase U32
M8Z30_RS06385	COG0572	uridine kinase
M8Z30_RS06390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M8Z30_RS06400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8Z30_RS06405	COG1984	allophanate hydrolase subunit 2
M8Z30_RS06410	COG0511	ligase activity, forming carbon-carbon bonds
M8Z30_RS06415	COG0439	Biotin carboxylase
M8Z30_RS06420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M8Z30_RS06425	COG1914	H( )-stimulated, divalent metal cation uptake system
M8Z30_RS06430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M8Z30_RS06435	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M8Z30_RS06440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M8Z30_RS06445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M8Z30_RS06450	COG1534	Rna-binding protein
M8Z30_RS06455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M8Z30_RS06460	COG1713	HD superfamily hydrolase involved in NAD metabolism
M8Z30_RS06465	COG0799	negative regulation of ribosome biogenesis
M8Z30_RS06470	COG2226	methyltransferase
M8Z30_RS06480	COG2131	deaminase
M8Z30_RS06485	COG2333	competence protein COMEC
M8Z30_RS06485	COG0658	competence protein
M8Z30_RS06490	COG1466	dna polymerase III delta subunit
M8Z30_RS06495	COG0268	Binds directly to 16S ribosomal RNA
M8Z30_RS06500	COG0481	GTPase activity
M8Z30_RS06505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M8Z30_RS06510	COG1420	regulation of RNA biosynthetic process
M8Z30_RS06515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M8Z30_RS06520	COG0443	Heat shock 70 kDa protein
M8Z30_RS06525	COG0484	heat shock protein binding
M8Z30_RS06530	COG2264	protein methyltransferase activity
M8Z30_RS06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M8Z30_RS06540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8Z30_RS06550	COG1030	water channel activity
M8Z30_RS06555	COG4864	UPF0365 protein
M8Z30_RS06565	COG1702	phosphate starvation-inducible protein PhoH
M8Z30_RS06570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M8Z30_RS06575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M8Z30_RS06580	COG0295	cytidine deaminase activity
M8Z30_RS06585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M8Z30_RS06590	COG1381	Involved in DNA repair and RecF pathway recombination
M8Z30_RS06595	COG0423	glycine-tRNA ligase activity
M8Z30_RS06600	COG0517	IMP dehydrogenase activity
M8Z30_RS06605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M8Z30_RS06610	COG0358	DNA primase activity
M8Z30_RS06615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M8Z30_RS06620	COG2384	SAM-dependent methyltransferase
M8Z30_RS06625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M8Z30_RS06630	COG0513	Belongs to the DEAD box helicase family
M8Z30_RS06635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M8Z30_RS06640	COG1121	(ABC) transporter
M8Z30_RS06645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8Z30_RS06650	COG0735	belongs to the Fur family
M8Z30_RS06655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M8Z30_RS06660	COG0768	penicillin binding
M8Z30_RS06665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M8Z30_RS06670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M8Z30_RS06680	COG4483	Protein conserved in bacteria
M8Z30_RS06685	COG1940	carbohydrate kinase activity
M8Z30_RS06690	COG0011	TIGRFAM Protein of
M8Z30_RS06700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M8Z30_RS06705	COG1459	type II secretion system
M8Z30_RS06710	COG4537	Required for transformation and DNA binding
M8Z30_RS06730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M8Z30_RS06735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M8Z30_RS06740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M8Z30_RS06745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M8Z30_RS06755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M8Z30_RS06760	COG0095	Lipoate-protein ligase
M8Z30_RS06775	COG0006	proline dipeptidase activity
M8Z30_RS06780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M8Z30_RS06785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M8Z30_RS06795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M8Z30_RS06800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8Z30_RS06805	COG0511	ligase activity, forming carbon-carbon bonds
M8Z30_RS06810	COG0439	Biotin carboxylase
M8Z30_RS06815	COG1302	Protein conserved in bacteria
M8Z30_RS06820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8Z30_RS06825	COG1570	exodeoxyribonuclease VII activity
M8Z30_RS06830	COG1722	exodeoxyribonuclease VII activity
M8Z30_RS06840	COG1438	arginine binding
M8Z30_RS06845	COG0497	DNA recombination
M8Z30_RS06850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8Z30_RS06855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8Z30_RS06860	COG0022	dehydrogenase e1 component
M8Z30_RS06865	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8Z30_RS06875	COG4129	membrane
M8Z30_RS06885	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8Z30_RS06890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M8Z30_RS06895	COG0366	Alpha amylase catalytic
M8Z30_RS06905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M8Z30_RS06910	COG1234	tRNA 3'-trailer cleavage
M8Z30_RS06915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M8Z30_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS06925	COG0667	Aldo Keto reductase
M8Z30_RS06930	COG0494	nUDIX hydrolase
M8Z30_RS06935	COG0735	belongs to the Fur family
M8Z30_RS06940	COG4974	Belongs to the 'phage' integrase family
M8Z30_RS06950	COG1547	Domain of unknown function (DUF309)
M8Z30_RS06955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M8Z30_RS06960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M8Z30_RS06965	COG1187	pseudouridine synthase activity
M8Z30_RS06970	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS06985	COG1141	Ferredoxin
M8Z30_RS06995	COG0514	ATP-dependent DNA helicase (RecQ)
M8Z30_RS07000	COG1388	LysM domain
M8Z30_RS07005	COG0492	ferredoxin-NADP+ reductase activity
M8Z30_RS07010	COG0252	asparaginase activity
M8Z30_RS07015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M8Z30_RS07020	COG0539	negative regulation of cytoplasmic translation
M8Z30_RS07025	COG1160	GTP binding
M8Z30_RS07030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M8Z30_RS07045	COG2226	methyltransferase
M8Z30_RS07055	COG0105	UTP biosynthetic process
M8Z30_RS07060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M8Z30_RS07065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M8Z30_RS07070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M8Z30_RS07080	COG5582	Belongs to the UPF0302 family
M8Z30_RS07085	COG4347	Protein of unknown function (DUF1405)
M8Z30_RS07090	COG2738	Putative neutral zinc metallopeptidase
M8Z30_RS07095	COG1694	Mazg nucleotide pyrophosphohydrolase
M8Z30_RS07100	COG0438	transferase activity, transferring glycosyl groups
M8Z30_RS07105	COG0617	tRNA 3'-terminal CCA addition
M8Z30_RS07110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M8Z30_RS07110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M8Z30_RS07115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M8Z30_RS07115	COG1199	ATP-dependent helicase activity
M8Z30_RS07120	COG0017	Asparaginyl-tRNA synthetase
M8Z30_RS07125	COG3935	DnaD domain protein
M8Z30_RS07130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8Z30_RS07140	COG4499	WXG100 protein secretion system (Wss), protein YukC
M8Z30_RS07140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M8Z30_RS07145	COG3331	DNA recombination
M8Z30_RS07155	COG4474	Belongs to the UPF0398 family
M8Z30_RS07160	COG3599	regulation of cell shape
M8Z30_RS07170	COG0116	Belongs to the methyltransferase superfamily
M8Z30_RS07205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M8Z30_RS07210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M8Z30_RS07225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M8Z30_RS07235	COG1413	lyase activity
M8Z30_RS07250	COG1136	(ABC) transporter
M8Z30_RS07275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M8Z30_RS07280	COG2190	(PTS) system
M8Z30_RS07285	COG4479	Belongs to the UPF0346 family
M8Z30_RS07290	COG0793	Belongs to the peptidase S41A family
M8Z30_RS07300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8Z30_RS07305	COG0671	phosphoesterase, PA-phosphatase related
M8Z30_RS07310	COG3842	ATPase activity
M8Z30_RS07315	COG4209	transmembrane transport
M8Z30_RS07325	COG0395	ABC-type sugar transport system, permease component
M8Z30_RS07335	COG0534	Mate efflux family protein
M8Z30_RS07340	COG1349	DNA-binding transcription factor activity
M8Z30_RS07345	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS07350	COG5002	protein histidine kinase activity
M8Z30_RS07355	COG0567	Dehydrogenase, E1 component
M8Z30_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8Z30_RS07380	COG0714	Associated with various cellular activities
M8Z30_RS07385	COG4548	von Willebrand factor, type A
M8Z30_RS07390	COG1114	Component of the transport system for branched-chain amino acids
M8Z30_RS07395	COG3853	Toxic anion resistance protein (TelA)
M8Z30_RS07405	COG1254	Belongs to the acylphosphatase family
M8Z30_RS07415	COG1278	Cold shock
M8Z30_RS07430	COG1131	(ABC) transporter
M8Z30_RS07450	COG1473	amidohydrolase
M8Z30_RS07455	COG2171	N-acyltransferase activity
M8Z30_RS07460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M8Z30_RS07465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M8Z30_RS07470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M8Z30_RS07475	COG0527	aspartate kinase activity
M8Z30_RS07480	COG0488	(ABC) transporter
M8Z30_RS07485	COG2996	Protein conserved in bacteria
M8Z30_RS07490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M8Z30_RS07495	COG0573	inorganic phosphate transmembrane transporter activity
M8Z30_RS07500	COG0581	inorganic phosphate transmembrane transporter activity
M8Z30_RS07505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M8Z30_RS07510	COG0704	Plays a role in the regulation of phosphate uptake
M8Z30_RS07545	COG4607	ABC-type enterochelin transport system periplasmic component
M8Z30_RS07555	COG2348	transferase activity, transferring amino-acyl groups
M8Z30_RS07560	COG2348	transferase activity, transferring amino-acyl groups
M8Z30_RS07570	COG0159	tryptophan synthase activity
M8Z30_RS07575	COG0133	tryptophan synthase activity
M8Z30_RS07580	COG0135	phosphoribosylanthranilate isomerase activity
M8Z30_RS07585	COG0134	indole-3-glycerol-phosphate synthase activity
M8Z30_RS07590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M8Z30_RS07595	COG0512	Glutamine amidotransferase of anthranilate synthase
M8Z30_RS07595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M8Z30_RS07600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8Z30_RS07605	COG0287	Prephenate dehydrogenase
M8Z30_RS07610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M8Z30_RS07615	COG1942	4-Oxalocrotonate Tautomerase
M8Z30_RS07630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M8Z30_RS07630	COG0392	lysyltransferase activity
M8Z30_RS07635	COG0628	permease
M8Z30_RS07640	COG3711	transcriptional antiterminator
M8Z30_RS07645	COG1115	amino acid carrier protein
M8Z30_RS07650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M8Z30_RS07655	COG0187	DNA topoisomerase II activity
M8Z30_RS07660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M8Z30_RS07665	COG4841	protein insertion into membrane
M8Z30_RS07670	COG0824	Thioesterase
M8Z30_RS07675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M8Z30_RS07680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M8Z30_RS07685	COG1970	mechanosensitive ion channel activity
M8Z30_RS07690	COG0419	ATPase involved in DNA repair
M8Z30_RS07695	COG0420	3'-5' exonuclease activity
M8Z30_RS07700	COG4846	Membrane protein involved in cytochrome C biogenesis
M8Z30_RS07710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M8Z30_RS07715	COG4224	UPF0291 protein
M8Z30_RS07725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M8Z30_RS07730	COG2340	Cysteine-rich secretory protein family
M8Z30_RS07735	COG0516	GMP reductase activity
M8Z30_RS07740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M8Z30_RS07750	COG0753	catalase activity
M8Z30_RS07755	COG0833	amino acid
M8Z30_RS07770	COG0083	homoserine kinase activity
M8Z30_RS07775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M8Z30_RS07780	COG0460	homoserine dehydrogenase
M8Z30_RS07785	COG0527	aspartate kinase activity
M8Z30_RS07805	COG1525	nuclease
M8Z30_RS07815	COG2197	response regulator
M8Z30_RS07820	COG4585	Histidine kinase
M8Z30_RS07830	COG1131	(ABC) transporter
M8Z30_RS07835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M8Z30_RS07905	COG4824	toxin secretion phage lysis holin
M8Z30_RS08015	COG1595	DNA-templated transcription, initiation
M8Z30_RS08045	COG0629	single-stranded DNA binding
M8Z30_RS08105	COG0174	glutamine synthetase
M8Z30_RS08110	COG0789	Transcriptional regulator
M8Z30_RS08115	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M8Z30_RS08120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M8Z30_RS08125	COG0386	Belongs to the glutathione peroxidase family
M8Z30_RS08130	COG1923	regulation of RNA biosynthetic process
M8Z30_RS08135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M8Z30_RS08145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M8Z30_RS08150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M8Z30_RS08155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M8Z30_RS08160	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M8Z30_RS08165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M8Z30_RS08170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M8Z30_RS08180	COG4550	Control of competence regulator ComK, YlbF/YmcA
M8Z30_RS08185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M8Z30_RS08195	COG4195	phage-related replication protein
M8Z30_RS08200	COG1013	pyruvate-flavodoxin oxidoreductase activity
M8Z30_RS08205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M8Z30_RS08205	COG0674	pyruvate-flavodoxin oxidoreductase activity
M8Z30_RS08210	COG1692	metallophosphoesterase
M8Z30_RS08220	COG1418	mRNA catabolic process
M8Z30_RS08225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M8Z30_RS08235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M8Z30_RS08250	COG0300	oxidoreductase activity
M8Z30_RS08255	COG0612	Peptidase, M16
M8Z30_RS08260	COG0612	Peptidase, M16
M8Z30_RS08265	COG2188	Transcriptional regulator
M8Z30_RS08270	COG1674	ftsk spoiiie
M8Z30_RS08275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8Z30_RS08280	COG1185	polyribonucleotide nucleotidyltransferase activity
M8Z30_RS08285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M8Z30_RS08290	COG0196	riboflavin kinase activity
M8Z30_RS08295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M8Z30_RS08300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M8Z30_RS08305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M8Z30_RS08310	COG1358	cellular component organization or biogenesis
M8Z30_RS08315	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M8Z30_RS08320	COG0195	Participates in both transcription termination and antitermination
M8Z30_RS08325	COG0779	Required for maturation of 30S ribosomal subunits
M8Z30_RS08330	COG2176	DNA-directed DNA polymerase activity
M8Z30_RS08335	COG0442	prolyl-tRNA aminoacylation
M8Z30_RS08345	COG4589	Belongs to the CDS family
M8Z30_RS08350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M8Z30_RS08355	COG0233	cytoplasmic translational termination
M8Z30_RS08360	COG0528	UMP kinase activity
M8Z30_RS08365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M8Z30_RS08370	COG0052	Belongs to the universal ribosomal protein uS2 family
M8Z30_RS08375	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M8Z30_RS08380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M8Z30_RS08385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M8Z30_RS08390	COG4974	Belongs to the 'phage' integrase family
M8Z30_RS08395	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M8Z30_RS08400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M8Z30_RS08405	COG0758	DNA mediated transformation
M8Z30_RS08415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M8Z30_RS08420	COG0045	succinate-CoA ligase (ADP-forming) activity
M8Z30_RS08425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M8Z30_RS08435	COG4485	Bacterial membrane protein, YfhO
M8Z30_RS08445	COG0335	large ribosomal subunit rRNA binding
M8Z30_RS08450	COG0336	Belongs to the RNA methyltransferase TrmD family
M8Z30_RS08455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M8Z30_RS08460	COG0228	four-way junction DNA binding
M8Z30_RS08465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M8Z30_RS08470	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M8Z30_RS08475	COG0552	protein localization to endoplasmic reticulum
M8Z30_RS08480	COG1196	nuclear chromosome segregation
M8Z30_RS08485	COG0571	ribonuclease III activity
M8Z30_RS08490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8Z30_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS08505	COG0416	fatty acid biosynthetic process
M8Z30_RS08510	COG1349	DNA-binding transcription factor activity
M8Z30_RS08515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M8Z30_RS08520	COG1461	Dihydroxyacetone kinase
M8Z30_RS08525	COG1302	Protein conserved in bacteria
M8Z30_RS08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M8Z30_RS08540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M8Z30_RS08545	COG1162	GTPase activity
M8Z30_RS08555	COG0631	protein serine/threonine phosphatase activity
M8Z30_RS08560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M8Z30_RS08565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M8Z30_RS08565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M8Z30_RS08570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M8Z30_RS08575	COG0242	peptide deformylase activity
M8Z30_RS08585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M8Z30_RS08590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M8Z30_RS08595	COG1758	RNA polymerase activity
M8Z30_RS08600	COG0194	GDP metabolic process
M8Z30_RS08620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M8Z30_RS08625	COG0284	orotidine-5'-phosphate decarboxylase activity
M8Z30_RS08630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M8Z30_RS08635	COG0505	Belongs to the CarA family
M8Z30_RS08640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M8Z30_RS08645	COG0540	Belongs to the ATCase OTCase family
M8Z30_RS08650	COG2233	PERMEase
M8Z30_RS08655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M8Z30_RS08660	COG0564	pseudouridine synthase activity
M8Z30_RS08665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M8Z30_RS08670	COG1388	LysM domain
M8Z30_RS08670	COG3942	CHAP domain
M8Z30_RS08680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M8Z30_RS08685	COG3599	regulation of cell shape
M8Z30_RS08695	COG0762	integral membrane protein
M8Z30_RS08700	COG1799	cell septum assembly
M8Z30_RS08705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M8Z30_RS08710	COG1496	oxidoreductase activity
M8Z30_RS08715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M8Z30_RS08720	COG0849	cell division
M8Z30_RS08725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M8Z30_RS08730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M8Z30_RS08735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8Z30_RS08740	COG0768	penicillin binding
M8Z30_RS08745	COG4839	cell division protein FtsL
M8Z30_RS08750	COG0275	rRNA processing
M8Z30_RS08755	COG2001	Belongs to the MraZ family
M8Z30_RS08760	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M8Z30_RS08765	COG0454	-acetyltransferase
M8Z30_RS08770	COG1011	Hydrolase
M8Z30_RS08800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M8Z30_RS08805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M8Z30_RS08810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M8Z30_RS08815	COG1053	succinate dehydrogenase
M8Z30_RS08820	COG2009	succinate dehydrogenase
M8Z30_RS08830	COG0322	excinuclease ABC activity
M8Z30_RS08835	COG3118	belongs to the thioredoxin family
M8Z30_RS08840	COG1193	negative regulation of DNA recombination
M8Z30_RS08845	COG1796	DNA polymerase
M8Z30_RS08845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M8Z30_RS08855	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M8Z30_RS08860	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M8Z30_RS08865	COG0072	phenylalanine-tRNA ligase activity
M8Z30_RS08865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8Z30_RS08870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M8Z30_RS08875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8Z30_RS08885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M8Z30_RS08895	COG1323	Belongs to the UPF0348 family
M8Z30_RS08900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M8Z30_RS08905	COG0742	ribosomal rna small subunit methyltransferase
M8Z30_RS08915	COG4471	UPF0298 protein
M8Z30_RS08920	COG0584	glycerophosphoryl diester phosphodiesterase
M8Z30_RS08925	COG3679	Belongs to the UPF0342 family
M8Z30_RS08930	COG2340	Cysteine-rich secretory protein family
M8Z30_RS08940	COG0109	protoheme IX farnesyltransferase activity
M8Z30_RS08945	COG1612	heme a metabolic process
M8Z30_RS08955	COG0772	Belongs to the SEDS family
M8Z30_RS08960	COG4838	Belongs to the UPF0358 family
M8Z30_RS08965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M8Z30_RS08970	COG4896	Protein conserved in bacteria
M8Z30_RS08980	COG1217	gtp-binding protein TYPA
M8Z30_RS08990	COG0483	inositol monophosphate 1-phosphatase activity
M8Z30_RS08995	COG4493	Belongs to the UPF0637 family
M8Z30_RS09000	COG1914	H( )-stimulated, divalent metal cation uptake system
M8Z30_RS09025	COG1176	ABC-type spermidine putrescine transport system, permease component I
M8Z30_RS09030	COG3842	ATPase activity
M8Z30_RS09040	COG4476	Belongs to the UPF0223 family
M8Z30_RS09050	COG0508	dehydrogenase complex catalyzes the overall conversion of
M8Z30_RS09055	COG0022	dehydrogenase e1 component
M8Z30_RS09060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M8Z30_RS09070	COG0242	peptide deformylase activity
M8Z30_RS09075	COG5503	Protein of unknown function (DUF1447)
M8Z30_RS09080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M8Z30_RS09085	COG0569	domain protein
M8Z30_RS09090	COG1294	oxidase, subunit
M8Z30_RS09095	COG1271	oxidase subunit
M8Z30_RS09105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M8Z30_RS09110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8Z30_RS09120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M8Z30_RS09135	COG4716	Myosin-crossreactive antigen
M8Z30_RS09145	COG4172	Belongs to the ABC transporter superfamily
M8Z30_RS09150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M8Z30_RS09155	COG0151	Belongs to the GarS family
M8Z30_RS09160	COG0138	bifunctional purine biosynthesis protein purh
M8Z30_RS09165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M8Z30_RS09170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M8Z30_RS09175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M8Z30_RS09180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8Z30_RS09185	COG0047	phosphoribosylformylglycinamidine synthase activity
M8Z30_RS09190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M8Z30_RS09195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M8Z30_RS09200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M8Z30_RS09205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M8Z30_RS09210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M8Z30_RS09220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M8Z30_RS09225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M8Z30_RS09230	COG1845	cytochrome c oxidase, subunit III
M8Z30_RS09235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M8Z30_RS09255	COG1316	TRANSCRIPTIONal
M8Z30_RS09280	COG3594	Acyltransferase
M8Z30_RS09285	COG0436	Aminotransferase
M8Z30_RS09290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M8Z30_RS09300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M8Z30_RS09305	COG1169	isochorismate synthase
M8Z30_RS09310	COG1575	Belongs to the MenA family. Type 1 subfamily
M8Z30_RS09315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M8Z30_RS09320	COG2314	TM2 domain
M8Z30_RS09375	COG4873	Protein conserved in bacteria
M8Z30_RS09385	COG0737	Belongs to the 5'-nucleotidase family
M8Z30_RS09390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8Z30_RS09395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M8Z30_RS09400	COG0861	Integral membrane protein TerC family
M8Z30_RS09405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M8Z30_RS09415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M8Z30_RS09420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M8Z30_RS09425	COG2814	Major facilitator Superfamily
M8Z30_RS09430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M8Z30_RS09435	COG2382	esterase
M8Z30_RS09440	COG0628	permease
M8Z30_RS09505	COG0569	domain protein
M8Z30_RS09505	COG0475	glutathione-regulated potassium exporter activity
M8Z30_RS09510	COG2239	Acts as a magnesium transporter
M8Z30_RS09515	COG0564	pseudouridine synthase activity
M8Z30_RS09520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M8Z30_RS09525	COG2357	RelA SpoT domain protein
M8Z30_RS09540	COG2346	COG2346, Truncated hemoglobins
M8Z30_RS09545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M8Z30_RS09550	COG1164	Oligoendopeptidase f
M8Z30_RS09560	COG4862	establishment of competence for transformation
M8Z30_RS09570	COG1393	Belongs to the ArsC family
M8Z30_RS09575	COG0180	Tryptophanyl-tRNA synthetase
M8Z30_RS09580	COG4166	transmembrane transport
M8Z30_RS09585	COG4608	Belongs to the ABC transporter superfamily
M8Z30_RS09590	COG0444	Belongs to the ABC transporter superfamily
M8Z30_RS09595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M8Z30_RS09600	COG0601	transmembrane transport
M8Z30_RS09615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M8Z30_RS09630	COG0542	response to heat
M8Z30_RS09645	COG0561	phosphatase activity
M8Z30_RS09650	COG0446	pyridine nucleotide-disulphide oxidoreductase
M8Z30_RS09670	COG0179	Fumarylacetoacetate (FAA) hydrolase
M8Z30_RS09675	COG1074	ATP-dependent DNA helicase activity
M8Z30_RS09680	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M8Z30_RS09695	COG0398	Pfam SNARE associated Golgi protein
M8Z30_RS09700	COG0166	Belongs to the GPI family
M8Z30_RS09705	COG0137	argininosuccinate synthase activity
M8Z30_RS09710	COG0165	Argininosuccinate lyase
M8Z30_RS09715	COG0584	glycerophosphoryl diester phosphodiesterase
M8Z30_RS09725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M8Z30_RS09740	COG1902	pentaerythritol trinitrate reductase activity
M8Z30_RS09745	COG1098	S1 RNA binding domain
M8Z30_RS09750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M8Z30_RS09760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8Z30_RS09760	COG2111	Na H antiporter
M8Z30_RS09765	COG2111	Na H antiporter
M8Z30_RS09770	COG1006	Multisubunit Na H antiporter MnhC subunit
M8Z30_RS09775	COG0651	ATP synthesis coupled electron transport
M8Z30_RS09780	COG1863	multisubunit Na H antiporter MnhE subunit
M8Z30_RS09785	COG2212	antiporter activity
M8Z30_RS09790	COG1320	monovalent cation:proton antiporter activity
M8Z30_RS09800	COG2050	protein possibly involved in aromatic compounds catabolism
M8Z30_RS09805	COG2056	Na+-H+ antiporter family
M8Z30_RS09810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M8Z30_RS09815	COG1252	NADH dehydrogenase
M8Z30_RS09820	COG0316	Belongs to the HesB IscA family
M8Z30_RS09825	COG4844	belongs to the
M8Z30_RS09830	COG1252	NADH dehydrogenase
M8Z30_RS09835	COG4837	Protein of unknown function (DUF1462)
M8Z30_RS09840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M8Z30_RS09845	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M8Z30_RS09850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M8Z30_RS09855	COG1696	Membrane protein involved in D-alanine export
M8Z30_RS09860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M8Z30_RS09870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M8Z30_RS09875	COG0647	UMP catabolic process
M8Z30_RS09880	COG2445	Protein of unknown function DUF86
M8Z30_RS09890	COG4470	Protein conserved in bacteria
M8Z30_RS09895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M8Z30_RS09900	COG0737	Belongs to the 5'-nucleotidase family
M8Z30_RS09905	COG0730	response to heat
M8Z30_RS09910	COG1801	Protein of unknown function DUF72
M8Z30_RS09915	COG1253	flavin adenine dinucleotide binding
M8Z30_RS09930	COG0719	Fe-S assembly protein
M8Z30_RS09935	COG0822	iron-sulfur transferase activity
M8Z30_RS09940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M8Z30_RS09945	COG0719	Fe-S assembly protein
M8Z30_RS09950	COG0396	ATPase activity
M8Z30_RS09960	COG3237	CsbD-like
M8Z30_RS09970	COG1464	Belongs to the NlpA lipoprotein family
M8Z30_RS09975	COG2011	ABC-type metal ion transport system permease component
M8Z30_RS09980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8Z30_RS09990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8Z30_RS09995	COG0509	glycine decarboxylation via glycine cleavage system
M8Z30_RS10000	COG1393	Belongs to the ArsC family
M8Z30_RS10005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M8Z30_RS10015	COG0710	3-dehydroquinate dehydratase activity
M8Z30_RS10020	COG1764	response to oxidative stress
M8Z30_RS10075	COG4195	phage-related replication protein
M8Z30_RS10090	COG1278	Cold shock
M8Z30_RS10115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M8Z30_RS10155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M8Z30_RS10160	COG0557	exoribonuclease II activity
M8Z30_RS10165	COG1647	Serine aminopeptidase, S33
M8Z30_RS10170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8Z30_RS10180	COG0148	phosphopyruvate hydratase activity
M8Z30_RS10185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M8Z30_RS10190	COG0149	triose-phosphate isomerase activity
M8Z30_RS10195	COG0126	phosphoglycerate kinase activity
M8Z30_RS10200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M8Z30_RS10220	COG1090	epimerase
M8Z30_RS10235	COG0740	serine-type endopeptidase activity
M8Z30_RS10245	COG1481	regulation of sporulation
M8Z30_RS10250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M8Z30_RS10255	COG1660	Displays ATPase and GTPase activities
M8Z30_RS10260	COG0492	ferredoxin-NADP+ reductase activity
M8Z30_RS10275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M8Z30_RS10280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M8Z30_RS10285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M8Z30_RS10290	COG0556	nucleotide-excision repair
M8Z30_RS10305	COG3942	CHAP domain
M8Z30_RS10305	COG1388	LysM domain
M8Z30_RS10315	COG0653	protein targeting
M8Z30_RS10320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M8Z30_RS10325	COG1040	competence protein
M8Z30_RS10330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M8Z30_RS10340	COG1739	Uncharacterized protein family UPF0029
M8Z30_RS10345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M8Z30_RS10350	COG2199	diguanylate cyclase activity
M8Z30_RS10365	COG2195	Cleaves the N-terminal amino acid of tripeptides
M8Z30_RS10370	COG1929	Belongs to the glycerate kinase type-1 family
M8Z30_RS10390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M8Z30_RS10405	COG4604	ABC transporter, ATP-binding protein
M8Z30_RS10410	COG4605	iron ion homeostasis
M8Z30_RS10415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8Z30_RS10425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8Z30_RS10430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M8Z30_RS10435	COG1780	Probably involved in ribonucleotide reductase function
M8Z30_RS10445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M8Z30_RS10450	COG3104	oligopeptide transport
M8Z30_RS10460	COG1597	lipid kinase activity
M8Z30_RS10465	COG1454	alcohol dehydrogenase
M8Z30_RS10465	COG1012	belongs to the aldehyde dehydrogenase family
M8Z30_RS10470	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
M8Z30_RS10475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M8Z30_RS10480	COG1174	glycine betaine transport
M8Z30_RS10490	COG0514	ATP-dependent DNA helicase (RecQ)
M8Z30_RS10495	COG0488	(ABC) transporter
M8Z30_RS10510	COG1368	sulfuric ester hydrolase activity
M8Z30_RS10520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M8Z30_RS10535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M8Z30_RS10545	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M8Z30_RS10550	COG0720	synthase
M8Z30_RS10555	COG0602	queuosine metabolic process
M8Z30_RS10580	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS10585	COG5002	protein histidine kinase activity
M8Z30_RS10590	COG0463	Glycosyl transferase, family 2
M8Z30_RS10595	COG0656	L-ascorbic acid biosynthetic process
M8Z30_RS10600	COG1253	flavin adenine dinucleotide binding
M8Z30_RS10605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M8Z30_RS10610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M8Z30_RS10610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8Z30_RS10610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M8Z30_RS10615	COG1105	Belongs to the carbohydrate kinase PfkB family
M8Z30_RS10620	COG1349	DNA-binding transcription factor activity
M8Z30_RS10625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M8Z30_RS10650	COG0415	Belongs to the DNA photolyase family
M8Z30_RS10655	COG0471	metal ion transport
M8Z30_RS10660	COG0039	L-malate dehydrogenase activity
M8Z30_RS10680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M8Z30_RS10685	COG4988	ABC transporter
M8Z30_RS10690	COG1968	undecaprenyl-diphosphatase activity
M8Z30_RS10705	COG1671	Belongs to the UPF0178 family
M8Z30_RS10710	COG1611	Belongs to the LOG family
M8Z30_RS10735	COG2839	Protein conserved in bacteria
M8Z30_RS10740	COG2814	Major facilitator Superfamily
M8Z30_RS10745	COG0583	DNA-binding transcription factor activity
M8Z30_RS10765	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M8Z30_RS10775	COG0217	transcriptional regulatory protein
M8Z30_RS10795	COG1388	LysM domain
M8Z30_RS10795	COG3942	CHAP domain
M8Z30_RS10800	COG0306	phosphate transporter
M8Z30_RS10805	COG1392	Phosphate transport regulator
M8Z30_RS10810	COG0577	efflux transmembrane transporter activity
M8Z30_RS10815	COG1136	(ABC) transporter
M8Z30_RS10820	COG2205	protein histidine kinase activity
M8Z30_RS10825	COG0745	RESPONSE REGULATOR receiver
M8Z30_RS10830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8Z30_RS10845	COG3949	Membrane
M8Z30_RS10855	COG1120	ATPase activity
M8Z30_RS10860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M8Z30_RS10865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8Z30_RS10870	COG1132	(ABC) transporter
M8Z30_RS10875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M8Z30_RS10885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8Z30_RS10890	COG1682	transport, permease protein
M8Z30_RS10895	COG1134	teichoic acid transport
M8Z30_RS10900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M8Z30_RS10910	COG1321	iron dependent repressor
M8Z30_RS10915	COG1121	(ABC) transporter
M8Z30_RS10920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M8Z30_RS10925	COG0803	Belongs to the bacterial solute-binding protein 9 family
M8Z30_RS10935	COG1320	monovalent cation:proton antiporter activity
M8Z30_RS10940	COG2212	antiporter activity
M8Z30_RS10945	COG1863	multisubunit Na H antiporter MnhE subunit
M8Z30_RS10950	COG0651	ATP synthesis coupled electron transport
M8Z30_RS10955	COG1006	Multisubunit Na H antiporter MnhC subunit
M8Z30_RS10960	COG2111	Na H antiporter
M8Z30_RS10965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8Z30_RS10965	COG2111	Na H antiporter
M8Z30_RS10995	COG0596	Alpha beta hydrolase
M8Z30_RS11015	COG0546	phosphoglycolate phosphatase activity
M8Z30_RS11020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M8Z30_RS11025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M8Z30_RS11035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M8Z30_RS11040	COG0018	arginyl-trna synthetase
M8Z30_RS11055	COG1064	alcohol dehydrogenase
M8Z30_RS11060	COG3875	lactate racemase activity
M8Z30_RS11065	COG1606	tRNA processing
M8Z30_RS11070	COG1691	(AIR) carboxylase
M8Z30_RS11075	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
M8Z30_RS11085	COG1078	dGTPase activity
M8Z30_RS11095	COG0667	Aldo Keto reductase
M8Z30_RS11105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M8Z30_RS11110	COG4844	belongs to the
M8Z30_RS11130	COG0095	Lipoate-protein ligase
M8Z30_RS11135	COG0280	phosphate acetyltransferase
M8Z30_RS11140	COG3253	May function as heme-dependent peroxidase
M8Z30_RS11160	COG0531	amino acid
M8Z30_RS11165	COG2363	Small membrane protein
M8Z30_RS11175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M8Z30_RS11185	COG0351	phosphomethylpyrimidine kinase
M8Z30_RS11205	COG0183	Belongs to the thiolase family
M8Z30_RS11210	COG0318	PFAM AMP-dependent synthetase and ligase
M8Z30_RS11225	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M8Z30_RS11230	COG0363	glucosamine-6-phosphate deaminase activity
M8Z30_RS11240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M8Z30_RS11245	COG1469	GTP cyclohydrolase I activity
M8Z30_RS11270	COG0431	NADPH-dependent FMN reductase
M8Z30_RS11275	COG0561	phosphatase activity
M8Z30_RS11285	COG1428	Deoxynucleoside kinase
M8Z30_RS11290	COG1428	Deoxynucleoside kinase
M8Z30_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
M8Z30_RS11300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M8Z30_RS11305	COG0546	phosphoglycolate phosphatase activity
M8Z30_RS11310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M8Z30_RS11315	COG1063	alcohol dehydrogenase
M8Z30_RS11320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M8Z30_RS11325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M8Z30_RS11330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M8Z30_RS11350	COG1473	amidohydrolase
M8Z30_RS11355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M8Z30_RS11360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M8Z30_RS11370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M8Z30_RS11380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M8Z30_RS11385	COG0085	RNA polymerase activity
M8Z30_RS11390	COG2813	Specifically methylates the guanine in position
M8Z30_RS11395	COG0222	ribosome binding
M8Z30_RS11400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M8Z30_RS11405	COG0081	regulation of translation
M8Z30_RS11410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M8Z30_RS11415	COG0250	Participates in transcription elongation, termination and antitermination
M8Z30_RS11420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M8Z30_RS11425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M8Z30_RS11435	COG3688	RNA-binding protein containing a PIN domain
M8Z30_RS11440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M8Z30_RS11445	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M8Z30_RS11450	COG0215	cysteine-tRNA ligase activity
M8Z30_RS11455	COG1045	serine acetyltransferase
M8Z30_RS11460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M8Z30_RS11465	COG4956	integral membrane protein (PIN domain superfamily)
M8Z30_RS11470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M8Z30_RS11475	COG0542	response to heat
M8Z30_RS11485	COG3880	PFAM UvrB UvrC protein
M8Z30_RS11490	COG4463	regulation of RNA biosynthetic process
M8Z30_RS11495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M8Z30_RS11505	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M8Z30_RS11510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M8Z30_RS11515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M8Z30_RS11600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M8Z30_RS11605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M8Z30_RS11610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M8Z30_RS11615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M8Z30_RS11620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8Z30_RS11625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M8Z30_RS11630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M8Z30_RS11635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M8Z30_RS11640	COG0037	tRNA processing
M8Z30_RS11645	COG1098	S1 RNA binding domain
M8Z30_RS11655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M8Z30_RS11660	COG3956	TIGRFAM MazG family protein
M8Z30_RS11665	COG2244	polysaccharide biosynthetic process
M8Z30_RS11670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M8Z30_RS11675	COG0193	aminoacyl-tRNA hydrolase activity
M8Z30_RS11680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M8Z30_RS11685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M8Z30_RS11690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M8Z30_RS11695	COG2088	sporulation resulting in formation of a cellular spore
M8Z30_RS11700	COG0251	oxidation-reduction process
M8Z30_RS11705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8Z30_RS11710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M8Z30_RS11715	COG4466	Protein conserved in bacteria
M8Z30_RS11720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M8Z30_RS11725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M8Z30_RS11730	COG0084	hydrolase, TatD family'
M8Z30_RS11735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8Z30_RS11735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M8Z30_RS11740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M8Z30_RS11745	COG2827	Endonuclease containing a URI domain
M8Z30_RS11750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M8Z30_RS11755	COG4467	Involved in initiation control of chromosome replication
M8Z30_RS11760	COG1774	PSP1 C-terminal conserved region
M8Z30_RS11765	COG0470	DNA polymerase III
M8Z30_RS11770	COG3870	Protein conserved in bacteria
M8Z30_RS11775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M8Z30_RS11780	COG1982	Orn Lys Arg decarboxylase major
M8Z30_RS11805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M8Z30_RS11810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M8Z30_RS11815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M8Z30_RS11835	COG2855	membrane
M8Z30_RS11840	COG0583	DNA-binding transcription factor activity
M8Z30_RS11850	COG0493	'glutamate synthase
M8Z30_RS11855	COG0067	glutamate synthase
M8Z30_RS11855	COG0070	glutamate synthase
M8Z30_RS11855	COG0069	glutamate synthase activity
M8Z30_RS11860	COG0583	DNA-binding transcription factor activity
M8Z30_RS11885	COG0438	transferase activity, transferring glycosyl groups
M8Z30_RS11890	COG1388	LysM domain
M8Z30_RS11890	COG3942	CHAP domain
M8Z30_RS11900	COG2011	ABC-type metal ion transport system permease component
M8Z30_RS11905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M8Z30_RS11910	COG0626	cystathionine gamma-synthase activity
M8Z30_RS11915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M8Z30_RS11925	COG0733	neurotransmitter:sodium symporter activity
M8Z30_RS11935	COG1647	Serine aminopeptidase, S33
M8Z30_RS11950	COG5609	conserved protein (DUF2294)
M8Z30_RS11955	COG3002	Belongs to the UPF0753 family
M8Z30_RS11960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M8Z30_RS11975	COG0523	cobalamin synthesis protein
M8Z30_RS12015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M8Z30_RS12015	COG0519	Catalyzes the synthesis of GMP from XMP
M8Z30_RS12020	COG0517	IMP dehydrogenase activity
M8Z30_RS12020	COG0516	GMP reductase activity
M8Z30_RS12025	COG2233	PERMEase
M8Z30_RS12030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M8Z30_RS12045	COG5183	chlorophyll binding
M8Z30_RS12050	COG1823	symporter activity
M8Z30_RS12065	COG0450	alkyl hydroperoxide reductase
M8Z30_RS12070	COG3634	alkyl hydroperoxide reductase activity
M8Z30_RS12090	COG1280	lysine exporter protein (LysE YggA)
M8Z30_RS12110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M8Z30_RS12120	COG0360	Binds together with S18 to 16S ribosomal RNA
M8Z30_RS12135	COG0012	GTP binding
M8Z30_RS12140	COG4481	Protein conserved in bacteria
M8Z30_RS12145	COG0668	transmembrane transport
M8Z30_RS12150	COG1475	DNA binding
M8Z30_RS12155	COG0626	cystathionine gamma-synthase activity
M8Z30_RS12160	COG0626	cystathionine gamma-synthase activity
M8Z30_RS12165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M8Z30_RS12165	COG0646	methionine synthase
M8Z30_RS12170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M8Z30_RS12180	COG0183	Belongs to the thiolase family
M8Z30_RS12195	COG1476	TRANSCRIPTIONal
M8Z30_RS12205	COG4555	ABC transporter
M8Z30_RS12265	COG1136	(ABC) transporter
M8Z30_RS12270	COG0577	efflux transmembrane transporter activity
M8Z30_RS12290	COG0577	efflux transmembrane transporter activity
M8Z30_RS12295	COG1136	(ABC) transporter
M8Z30_RS12330	COG1475	DNA binding
M8Z30_RS12335	COG0357	Ribosomal RNA small subunit methyltransferase G
M8Z30_RS12340	COG0445	tRNA wobble uridine modification
M8Z30_RS12345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M8Z30_RS12350	COG0594	ribonuclease P activity
M8Z30_RS12545	COG2211	Major facilitator Superfamily