locus-tag	class	description
EH163_RS00015	COG0739	heme binding
EH163_RS00110	COG0756	dUTP diphosphatase activity
EH163_RS00190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EH163_RS00250	COG4873	Protein conserved in bacteria
EH163_RS00260	COG0737	Belongs to the 5'-nucleotidase family
EH163_RS00265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EH163_RS00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EH163_RS00275	COG0861	Integral membrane protein TerC family
EH163_RS00280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EH163_RS00290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EH163_RS00295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EH163_RS00300	COG2814	Major facilitator Superfamily
EH163_RS00305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EH163_RS00310	COG2382	esterase
EH163_RS00315	COG0628	permease
EH163_RS00350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EH163_RS00360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EH163_RS00365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EH163_RS00395	COG0569	domain protein
EH163_RS00395	COG0475	glutathione-regulated potassium exporter activity
EH163_RS00400	COG2239	Acts as a magnesium transporter
EH163_RS00405	COG0564	pseudouridine synthase activity
EH163_RS00410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EH163_RS00415	COG2357	RelA SpoT domain protein
EH163_RS00430	COG2346	COG2346, Truncated hemoglobins
EH163_RS00435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EH163_RS00440	COG1164	Oligoendopeptidase f
EH163_RS00450	COG4862	establishment of competence for transformation
EH163_RS00460	COG1393	Belongs to the ArsC family
EH163_RS00465	COG0180	Tryptophanyl-tRNA synthetase
EH163_RS00470	COG4166	transmembrane transport
EH163_RS00475	COG4608	Belongs to the ABC transporter superfamily
EH163_RS00480	COG0444	Belongs to the ABC transporter superfamily
EH163_RS00485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EH163_RS00490	COG0601	transmembrane transport
EH163_RS00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EH163_RS00525	COG0542	response to heat
EH163_RS00540	COG0561	phosphatase activity
EH163_RS00545	COG0446	pyridine nucleotide-disulphide oxidoreductase
EH163_RS00555	COG0179	Fumarylacetoacetate (FAA) hydrolase
EH163_RS00560	COG1074	ATP-dependent DNA helicase activity
EH163_RS00565	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EH163_RS00580	COG0398	Pfam SNARE associated Golgi protein
EH163_RS00590	COG0166	Belongs to the GPI family
EH163_RS00595	COG0137	argininosuccinate synthase activity
EH163_RS00600	COG0165	Argininosuccinate lyase
EH163_RS00605	COG0584	glycerophosphoryl diester phosphodiesterase
EH163_RS00615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EH163_RS00620	COG1902	pentaerythritol trinitrate reductase activity
EH163_RS00625	COG1098	S1 RNA binding domain
EH163_RS00630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EH163_RS00640	COG2111	Na H antiporter
EH163_RS00640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EH163_RS00645	COG2111	Na H antiporter
EH163_RS00650	COG1006	Multisubunit Na H antiporter MnhC subunit
EH163_RS00655	COG0651	ATP synthesis coupled electron transport
EH163_RS00660	COG1863	multisubunit Na H antiporter MnhE subunit
EH163_RS00665	COG2212	antiporter activity
EH163_RS00670	COG1320	monovalent cation:proton antiporter activity
EH163_RS00680	COG2050	protein possibly involved in aromatic compounds catabolism
EH163_RS00685	COG2056	Na+-H+ antiporter family
EH163_RS00690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EH163_RS00695	COG1252	NADH dehydrogenase
EH163_RS00700	COG0316	Belongs to the HesB IscA family
EH163_RS00705	COG4844	belongs to the
EH163_RS00710	COG1252	NADH dehydrogenase
EH163_RS00715	COG4837	Protein of unknown function (DUF1462)
EH163_RS00720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EH163_RS00725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EH163_RS00730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EH163_RS00735	COG1696	Membrane protein involved in D-alanine export
EH163_RS00740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EH163_RS00750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EH163_RS00755	COG0647	UMP catabolic process
EH163_RS00760	COG2445	Protein of unknown function DUF86
EH163_RS00770	COG4470	Protein conserved in bacteria
EH163_RS00775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EH163_RS00780	COG0737	Belongs to the 5'-nucleotidase family
EH163_RS00785	COG0730	response to heat
EH163_RS00790	COG1801	Protein of unknown function DUF72
EH163_RS00795	COG1253	flavin adenine dinucleotide binding
EH163_RS00810	COG0719	Fe-S assembly protein
EH163_RS00815	COG0822	iron-sulfur transferase activity
EH163_RS00820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EH163_RS00825	COG0719	Fe-S assembly protein
EH163_RS00830	COG0396	ATPase activity
EH163_RS00840	COG3237	CsbD-like
EH163_RS00850	COG1464	Belongs to the NlpA lipoprotein family
EH163_RS00855	COG2011	ABC-type metal ion transport system permease component
EH163_RS00860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EH163_RS00870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EH163_RS00880	COG0509	glycine decarboxylation via glycine cleavage system
EH163_RS00885	COG1393	Belongs to the ArsC family
EH163_RS00890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EH163_RS00900	COG0710	3-dehydroquinate dehydratase activity
EH163_RS00905	COG1764	response to oxidative stress
EH163_RS00960	COG4195	phage-related replication protein
EH163_RS00975	COG1278	Cold shock
EH163_RS01015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EH163_RS01050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EH163_RS01055	COG0557	exoribonuclease II activity
EH163_RS01060	COG1647	Serine aminopeptidase, S33
EH163_RS01065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EH163_RS01075	COG0148	phosphopyruvate hydratase activity
EH163_RS01080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EH163_RS01085	COG0149	triose-phosphate isomerase activity
EH163_RS01090	COG0126	phosphoglycerate kinase activity
EH163_RS01095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EH163_RS01115	COG1090	epimerase
EH163_RS01125	COG0740	serine-type endopeptidase activity
EH163_RS01135	COG1481	regulation of sporulation
EH163_RS01140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EH163_RS01145	COG1660	Displays ATPase and GTPase activities
EH163_RS01150	COG0492	ferredoxin-NADP+ reductase activity
EH163_RS01165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EH163_RS01170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EH163_RS01175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EH163_RS01180	COG0556	nucleotide-excision repair
EH163_RS01200	COG3942	CHAP domain
EH163_RS01200	COG1388	LysM domain
EH163_RS01210	COG0653	protein targeting
EH163_RS01215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EH163_RS01220	COG1040	competence protein
EH163_RS01225	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EH163_RS01235	COG1739	Uncharacterized protein family UPF0029
EH163_RS01240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EH163_RS01245	COG2199	diguanylate cyclase activity
EH163_RS01260	COG2195	Cleaves the N-terminal amino acid of tripeptides
EH163_RS01270	COG1929	Belongs to the glycerate kinase type-1 family
EH163_RS01290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EH163_RS01305	COG4604	ABC transporter, ATP-binding protein
EH163_RS01310	COG4605	iron ion homeostasis
EH163_RS01315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EH163_RS01325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EH163_RS01330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EH163_RS01335	COG1780	Probably involved in ribonucleotide reductase function
EH163_RS01345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EH163_RS01350	COG3104	oligopeptide transport
EH163_RS01355	COG1597	lipid kinase activity
EH163_RS01360	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS01360	COG1454	alcohol dehydrogenase
EH163_RS01365	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
EH163_RS01370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EH163_RS01375	COG1174	glycine betaine transport
EH163_RS01385	COG0514	ATP-dependent DNA helicase (RecQ)
EH163_RS01390	COG0488	(ABC) transporter
EH163_RS01400	COG1368	sulfuric ester hydrolase activity
EH163_RS01410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EH163_RS01425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EH163_RS01435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EH163_RS01440	COG0720	synthase
EH163_RS01445	COG0602	queuosine metabolic process
EH163_RS01470	COG0745	RESPONSE REGULATOR receiver
EH163_RS01475	COG5002	protein histidine kinase activity
EH163_RS01480	COG0463	Glycosyl transferase, family 2
EH163_RS01490	COG0656	L-ascorbic acid biosynthetic process
EH163_RS01495	COG1253	flavin adenine dinucleotide binding
EH163_RS01500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EH163_RS01505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH163_RS01505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH163_RS01505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH163_RS01510	COG1105	Belongs to the carbohydrate kinase PfkB family
EH163_RS01515	COG1349	DNA-binding transcription factor activity
EH163_RS01525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EH163_RS01550	COG0415	Belongs to the DNA photolyase family
EH163_RS01555	COG0471	metal ion transport
EH163_RS01560	COG0039	L-malate dehydrogenase activity
EH163_RS01585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EH163_RS01590	COG4988	ABC transporter
EH163_RS01595	COG1968	undecaprenyl-diphosphatase activity
EH163_RS01610	COG1671	Belongs to the UPF0178 family
EH163_RS01615	COG1611	Belongs to the LOG family
EH163_RS01640	COG2839	Protein conserved in bacteria
EH163_RS01645	COG2814	Major facilitator Superfamily
EH163_RS01650	COG0583	DNA-binding transcription factor activity
EH163_RS01670	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EH163_RS01680	COG0217	transcriptional regulatory protein
EH163_RS01700	COG3942	CHAP domain
EH163_RS01700	COG1388	LysM domain
EH163_RS01705	COG0306	phosphate transporter
EH163_RS01710	COG1392	Phosphate transport regulator
EH163_RS01715	COG0577	efflux transmembrane transporter activity
EH163_RS01720	COG1136	(ABC) transporter
EH163_RS01725	COG2205	protein histidine kinase activity
EH163_RS01730	COG0745	RESPONSE REGULATOR receiver
EH163_RS01735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EH163_RS01750	COG3949	Membrane
EH163_RS01760	COG1120	ATPase activity
EH163_RS01765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EH163_RS01775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EH163_RS01780	COG1132	(ABC) transporter
EH163_RS01795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EH163_RS01805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EH163_RS01810	COG1682	transport, permease protein
EH163_RS01815	COG1134	teichoic acid transport
EH163_RS01820	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EH163_RS01830	COG1321	iron dependent repressor
EH163_RS01835	COG1121	(ABC) transporter
EH163_RS01840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EH163_RS01845	COG0803	Belongs to the bacterial solute-binding protein 9 family
EH163_RS01855	COG1320	monovalent cation:proton antiporter activity
EH163_RS01860	COG2212	antiporter activity
EH163_RS01865	COG1863	multisubunit Na H antiporter MnhE subunit
EH163_RS01870	COG0651	ATP synthesis coupled electron transport
EH163_RS01875	COG1006	Multisubunit Na H antiporter MnhC subunit
EH163_RS01880	COG2111	Na H antiporter
EH163_RS01885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EH163_RS01885	COG2111	Na H antiporter
EH163_RS01925	COG0596	Alpha beta hydrolase
EH163_RS01945	COG0546	phosphoglycolate phosphatase activity
EH163_RS01950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EH163_RS01955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EH163_RS01970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EH163_RS01975	COG0018	arginyl-trna synthetase
EH163_RS01995	COG1064	alcohol dehydrogenase
EH163_RS02000	COG3875	lactate racemase activity
EH163_RS02005	COG1606	tRNA processing
EH163_RS02010	COG1691	(AIR) carboxylase
EH163_RS02015	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EH163_RS02025	COG1078	dGTPase activity
EH163_RS02035	COG0667	Aldo Keto reductase
EH163_RS02045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EH163_RS02050	COG4844	belongs to the
EH163_RS02070	COG0095	Lipoate-protein ligase
EH163_RS02075	COG0280	phosphate acetyltransferase
EH163_RS02080	COG3253	May function as heme-dependent peroxidase
EH163_RS02095	COG0531	amino acid
EH163_RS02100	COG2363	Small membrane protein
EH163_RS02110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EH163_RS02120	COG0351	phosphomethylpyrimidine kinase
EH163_RS02140	COG0183	Belongs to the thiolase family
EH163_RS02145	COG0318	PFAM AMP-dependent synthetase and ligase
EH163_RS02155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EH163_RS02160	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EH163_RS02165	COG0363	glucosamine-6-phosphate deaminase activity
EH163_RS02175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EH163_RS02180	COG1469	GTP cyclohydrolase I activity
EH163_RS02190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EH163_RS02195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EH163_RS02200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH163_RS02215	COG0431	NADPH-dependent FMN reductase
EH163_RS02220	COG0561	phosphatase activity
EH163_RS02235	COG1428	Deoxynucleoside kinase
EH163_RS02240	COG1428	Deoxynucleoside kinase
EH163_RS02250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EH163_RS02255	COG0546	phosphoglycolate phosphatase activity
EH163_RS02260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EH163_RS02265	COG1063	alcohol dehydrogenase
EH163_RS02270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EH163_RS02275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EH163_RS02280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EH163_RS02300	COG1473	amidohydrolase
EH163_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EH163_RS02310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EH163_RS02320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EH163_RS02330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EH163_RS02335	COG0085	RNA polymerase activity
EH163_RS02340	COG2813	Specifically methylates the guanine in position
EH163_RS02345	COG0222	ribosome binding
EH163_RS02350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EH163_RS02360	COG0081	regulation of translation
EH163_RS02365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EH163_RS02370	COG0250	Participates in transcription elongation, termination and antitermination
EH163_RS02375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EH163_RS02380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EH163_RS02390	COG3688	RNA-binding protein containing a PIN domain
EH163_RS02395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EH163_RS02400	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EH163_RS02405	COG0215	cysteine-tRNA ligase activity
EH163_RS02410	COG1045	serine acetyltransferase
EH163_RS02415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EH163_RS02420	COG4956	integral membrane protein (PIN domain superfamily)
EH163_RS02425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EH163_RS02430	COG0542	response to heat
EH163_RS02435	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EH163_RS02440	COG3880	PFAM UvrB UvrC protein
EH163_RS02445	COG4463	regulation of RNA biosynthetic process
EH163_RS02450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EH163_RS02460	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EH163_RS02465	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EH163_RS02470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EH163_RS02555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EH163_RS02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EH163_RS02565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EH163_RS02570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EH163_RS02575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EH163_RS02580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EH163_RS02585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EH163_RS02590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EH163_RS02595	COG0037	tRNA processing
EH163_RS02600	COG1098	S1 RNA binding domain
EH163_RS02610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EH163_RS02615	COG3956	TIGRFAM MazG family protein
EH163_RS02620	COG2244	polysaccharide biosynthetic process
EH163_RS02625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EH163_RS02630	COG0193	aminoacyl-tRNA hydrolase activity
EH163_RS02635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EH163_RS02640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EH163_RS02645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EH163_RS02650	COG2088	sporulation resulting in formation of a cellular spore
EH163_RS02655	COG0251	oxidation-reduction process
EH163_RS02660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EH163_RS02665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EH163_RS02670	COG4466	Protein conserved in bacteria
EH163_RS02675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EH163_RS02680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EH163_RS02685	COG0084	hydrolase, TatD family'
EH163_RS02690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EH163_RS02690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EH163_RS02695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EH163_RS02700	COG2827	Endonuclease containing a URI domain
EH163_RS02705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EH163_RS02710	COG4467	Involved in initiation control of chromosome replication
EH163_RS02715	COG1774	PSP1 C-terminal conserved region
EH163_RS02720	COG0470	DNA polymerase III
EH163_RS02725	COG3870	Protein conserved in bacteria
EH163_RS02730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EH163_RS02735	COG1982	Orn Lys Arg decarboxylase major
EH163_RS02760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EH163_RS02765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EH163_RS02770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EH163_RS02790	COG2855	membrane
EH163_RS02795	COG0583	DNA-binding transcription factor activity
EH163_RS02805	COG0493	'glutamate synthase
EH163_RS02810	COG0069	glutamate synthase activity
EH163_RS02810	COG0067	glutamate synthase
EH163_RS02810	COG0070	glutamate synthase
EH163_RS02815	COG0583	DNA-binding transcription factor activity
EH163_RS02840	COG0438	transferase activity, transferring glycosyl groups
EH163_RS02845	COG3942	CHAP domain
EH163_RS02845	COG1388	LysM domain
EH163_RS02855	COG2011	ABC-type metal ion transport system permease component
EH163_RS02860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EH163_RS02865	COG0626	cystathionine gamma-synthase activity
EH163_RS02870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EH163_RS02880	COG0733	neurotransmitter:sodium symporter activity
EH163_RS02890	COG1647	Serine aminopeptidase, S33
EH163_RS02905	COG5609	conserved protein (DUF2294)
EH163_RS02915	COG3002	Belongs to the UPF0753 family
EH163_RS02920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EH163_RS02940	COG0523	cobalamin synthesis protein
EH163_RS02955	COG0655	NAD(P)H dehydrogenase (quinone) activity
EH163_RS02990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EH163_RS02990	COG0519	Catalyzes the synthesis of GMP from XMP
EH163_RS02995	COG0516	GMP reductase activity
EH163_RS02995	COG0517	IMP dehydrogenase activity
EH163_RS03000	COG2233	PERMEase
EH163_RS03005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EH163_RS03020	COG5183	chlorophyll binding
EH163_RS03030	COG1823	symporter activity
EH163_RS03035	COG0778	Nitroreductase
EH163_RS03045	COG0450	alkyl hydroperoxide reductase
EH163_RS03050	COG3634	alkyl hydroperoxide reductase activity
EH163_RS03080	COG1280	lysine exporter protein (LysE YggA)
EH163_RS03105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EH163_RS03115	COG0360	Binds together with S18 to 16S ribosomal RNA
EH163_RS03130	COG0012	GTP binding
EH163_RS03135	COG4481	Protein conserved in bacteria
EH163_RS03140	COG0668	transmembrane transport
EH163_RS03145	COG1475	DNA binding
EH163_RS03155	COG0626	cystathionine gamma-synthase activity
EH163_RS03160	COG0626	cystathionine gamma-synthase activity
EH163_RS03165	COG0646	methionine synthase
EH163_RS03165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EH163_RS03170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EH163_RS03180	COG0183	Belongs to the thiolase family
EH163_RS03195	COG1476	TRANSCRIPTIONal
EH163_RS03205	COG4555	ABC transporter
EH163_RS03245	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EH163_RS03245	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EH163_RS03245	COG3266	domain, Protein
EH163_RS03245	COG3266	domain, Protein
EH163_RS03245	COG4932	domain protein
EH163_RS03245	COG4932	domain protein
EH163_RS03270	COG1136	(ABC) transporter
EH163_RS03275	COG0577	efflux transmembrane transporter activity
EH163_RS03290	COG0577	efflux transmembrane transporter activity
EH163_RS03295	COG1136	(ABC) transporter
EH163_RS03335	COG1475	DNA binding
EH163_RS03340	COG0357	Ribosomal RNA small subunit methyltransferase G
EH163_RS03345	COG0445	tRNA wobble uridine modification
EH163_RS03350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EH163_RS03355	COG0594	ribonuclease P activity
EH163_RS03365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EH163_RS03370	COG0592	DNA-directed DNA polymerase activity
EH163_RS03375	COG2501	S4 domain
EH163_RS03380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EH163_RS03385	COG0187	DNA topoisomerase II activity
EH163_RS03390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EH163_RS03395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EH163_RS03400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EH163_RS03420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EH163_RS03430	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EH163_RS03435	COG0359	binds to the 23S rRNA
EH163_RS03440	COG0305	Participates in initiation and elongation during chromosome replication
EH163_RS03445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EH163_RS03465	COG0745	RESPONSE REGULATOR receiver
EH163_RS03470	COG5002	protein histidine kinase activity
EH163_RS03475	COG4863	YycH protein
EH163_RS03485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EH163_RS03490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EH163_RS03495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EH163_RS03520	COG3425	synthase
EH163_RS03530	COG0584	glycerophosphoryl diester phosphodiesterase
EH163_RS03535	COG2030	dehydratase
EH163_RS03625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EH163_RS03635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EH163_RS03710	COG2235	arginine
EH163_RS03720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EH163_RS03725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EH163_RS03775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EH163_RS03780	COG2801	Transposase and inactivated derivatives
EH163_RS03825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EH163_RS03875	COG0076	glutamate decarboxylase activity
EH163_RS03885	COG0210	DNA helicase
EH163_RS03890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EH163_RS03895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EH163_RS03905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EH163_RS03945	COG1131	(ABC) transporter
EH163_RS03960	COG0745	RESPONSE REGULATOR receiver
EH163_RS03965	COG5002	protein histidine kinase activity
EH163_RS03995	COG2217	Heavy metal translocating P-type atpase
EH163_RS04000	COG1388	LysM domain
EH163_RS04005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EH163_RS04010	COG2210	Belongs to the sulfur carrier protein TusA family
EH163_RS04015	COG1937	Protein conserved in bacteria
EH163_RS04020	COG0730	response to heat
EH163_RS04025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH163_RS04030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EH163_RS04050	COG0640	Transcriptional regulator
EH163_RS04055	COG0701	Predicted permease
EH163_RS04075	COG0668	transmembrane transport
EH163_RS04080	COG0561	phosphatase activity
EH163_RS04120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EH163_RS04125	COG0579	oxidoreductase
EH163_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS04150	COG1755	Isoprenylcysteine carboxyl methyltransferase
EH163_RS04160	COG4753	response regulator
EH163_RS04160	COG2207	Transcriptional regulator
EH163_RS04165	COG2972	Histidine kinase
EH163_RS04225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EH163_RS04230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EH163_RS04235	COG0156	8-amino-7-oxononanoate synthase activity
EH163_RS04240	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
EH163_RS04265	COG0523	cobalamin synthesis protein
EH163_RS04290	COG1053	succinate dehydrogenase
EH163_RS04290	COG0431	NADPH-dependent FMN reductase
EH163_RS04290	COG3976	FMN-binding domain protein
EH163_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS04340	COG0601	transmembrane transport
EH163_RS04350	COG0444	Belongs to the ABC transporter superfamily
EH163_RS04355	COG1124	(ABC) transporter
EH163_RS04365	COG1882	Formate acetyltransferase
EH163_RS04370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EH163_RS04375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH163_RS04380	COG1114	Component of the transport system for branched-chain amino acids
EH163_RS04385	COG1309	transcriptional regulator
EH163_RS04390	COG3246	L-lysine catabolic process to acetate
EH163_RS04395	COG1250	3-hydroxyacyl-CoA dehydrogenase
EH163_RS04430	COG1288	antiporter activity
EH163_RS04435	COG0549	Belongs to the carbamate kinase family
EH163_RS04440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EH163_RS04450	COG0346	lactoylglutathione lyase activity
EH163_RS04455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EH163_RS04460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EH163_RS04470	COG2376	Dihydroxyacetone kinase
EH163_RS04475	COG1461	Dihydroxyacetone kinase
EH163_RS04480	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EH163_RS04490	COG2814	Major facilitator Superfamily
EH163_RS04495	COG0583	DNA-binding transcription factor activity
EH163_RS04505	COG2814	Major facilitator Superfamily
EH163_RS04540	COG2814	Major facilitator Superfamily
EH163_RS04555	COG2962	Rard protein
EH163_RS04560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EH163_RS04565	COG0471	metal ion transport
EH163_RS04570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EH163_RS04575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EH163_RS04580	COG0022	dehydrogenase e1 component
EH163_RS04585	COG0508	dehydrogenase complex catalyzes the overall conversion of
EH163_RS04605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EH163_RS04610	COG1054	Belongs to the UPF0176 family
EH163_RS04615	COG3386	PFAM SMP-30 Gluconolaconase
EH163_RS04620	COG2353	YceI-like domain
EH163_RS04630	COG0579	oxidoreductase
EH163_RS04655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EH163_RS04660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EH163_RS04665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EH163_RS04670	COG0131	Imidazoleglycerol-phosphate dehydratase
EH163_RS04675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EH163_RS04680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EH163_RS04685	COG0107	imidazoleglycerol-phosphate synthase activity
EH163_RS04690	COG0140	phosphoribosyl-ATP diphosphatase activity
EH163_RS04690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EH163_RS04695	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EH163_RS04705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EH163_RS04715	COG0726	polysaccharide deacetylase
EH163_RS04725	COG1215	transferase activity, transferring glycosyl groups
EH163_RS04730	COG1309	transcriptional regulator
EH163_RS04745	COG2814	Major facilitator Superfamily
EH163_RS04750	COG0737	Belongs to the 5'-nucleotidase family
EH163_RS04765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EH163_RS04770	COG3639	organic phosphonate transmembrane transporter activity
EH163_RS04790	COG0201	protein transport
EH163_RS04800	COG1073	alpha beta
EH163_RS04810	COG0653	protein targeting
EH163_RS04815	COG0438	transferase activity, transferring glycosyl groups
EH163_RS04840	COG2814	Major facilitator Superfamily
EH163_RS04845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EH163_RS04860	COG1764	response to oxidative stress
EH163_RS04870	COG3942	CHAP domain
EH163_RS04870	COG1705	Flagellar rod assembly protein muramidase FlgJ
EH163_RS04880	COG1482	cell wall glycoprotein biosynthetic process
EH163_RS04885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH163_RS04885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EH163_RS04885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH163_RS04890	COG3711	transcriptional antiterminator
EH163_RS04890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH163_RS04920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH163_RS04930	COG1438	arginine binding
EH163_RS04935	COG2235	arginine
EH163_RS04940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EH163_RS04950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EH163_RS04960	COG2843	Capsule synthesis protein
EH163_RS04970	COG3961	Belongs to the TPP enzyme family
EH163_RS05015	COG4195	phage-related replication protein
EH163_RS05025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EH163_RS05030	COG0702	epimerase
EH163_RS05035	COG1785	Belongs to the alkaline phosphatase family
EH163_RS05050	COG2205	protein histidine kinase activity
EH163_RS05055	COG1136	(ABC) transporter
EH163_RS05070	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EH163_RS05095	COG1846	Transcriptional regulator
EH163_RS05100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EH163_RS05105	COG0386	Belongs to the glutathione peroxidase family
EH163_RS05115	COG0175	sulfate reduction
EH163_RS05120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EH163_RS05125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EH163_RS05140	COG0730	response to heat
EH163_RS05145	COG2046	Belongs to the sulfate adenylyltransferase family
EH163_RS05150	COG0529	Catalyzes the synthesis of activated sulfate
EH163_RS05160	COG1328	CTP reductase activity
EH163_RS05165	COG0602	queuosine metabolic process
EH163_RS05170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EH163_RS05185	COG1510	regulation of RNA biosynthetic process
EH163_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS05195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EH163_RS05200	COG1473	amidohydrolase
EH163_RS05215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EH163_RS05220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EH163_RS05220	COG0574	Belongs to the PEP-utilizing enzyme family
EH163_RS05225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EH163_RS05230	COG0579	oxidoreductase
EH163_RS05240	COG3588	fructose-bisphosphate aldolase
EH163_RS05250	COG0446	pyridine nucleotide-disulphide oxidoreductase
EH163_RS05285	COG0531	amino acid
EH163_RS05290	COG0583	DNA-binding transcription factor activity
EH163_RS05295	COG0039	L-malate dehydrogenase activity
EH163_RS05300	COG0028	Belongs to the TPP enzyme family
EH163_RS05305	COG3527	Alpha-acetolactate decarboxylase
EH163_RS05315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EH163_RS05320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EH163_RS05325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EH163_RS05340	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EH163_RS05350	COG0167	dihydroorotate dehydrogenase activity
EH163_RS05355	COG3001	Fructosamine kinase
EH163_RS05360	COG1113	amino acid transport
EH163_RS05380	COG0741	lytic transglycosylase activity
EH163_RS05390	COG3942	CHAP domain
EH163_RS05395	COG0436	Aminotransferase
EH163_RS05405	COG2608	mercury ion transmembrane transporter activity
EH163_RS05410	COG2217	Heavy metal translocating P-type atpase
EH163_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS05425	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS05450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EH163_RS05455	COG3425	synthase
EH163_RS05475	COG0583	DNA-binding transcription factor activity
EH163_RS05480	COG1380	Effector of murein hydrolase LrgA
EH163_RS05485	COG1346	cytolysis
EH163_RS05490	COG0028	Belongs to the TPP enzyme family
EH163_RS05495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH163_RS05495	COG2190	(PTS) system
EH163_RS05495	COG1263	PTS System
EH163_RS05510	COG1063	alcohol dehydrogenase
EH163_RS05515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EH163_RS05520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EH163_RS05535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EH163_RS05545	COG2843	Capsule synthesis protein
EH163_RS05560	COG4975	Glucose uptake
EH163_RS05565	COG1869	D-ribose catabolic process
EH163_RS05580	COG1070	Carbohydrate kinase
EH163_RS05600	COG1760	l-serine dehydratase
EH163_RS05605	COG1760	l-serine dehydratase
EH163_RS05620	COG3764	Sortase (surface protein transpeptidase)
EH163_RS05630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EH163_RS05635	COG0778	Nitroreductase
EH163_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS05655	COG2514	catechol 2,3-dioxygenase activity
EH163_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS05675	COG3949	Membrane
EH163_RS05690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EH163_RS05695	COG0586	Pfam SNARE associated Golgi protein
EH163_RS05700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EH163_RS05705	COG2022	thiamine diphosphate biosynthetic process
EH163_RS05715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EH163_RS05725	COG2271	Major facilitator Superfamily
EH163_RS05740	COG4876	unkown
EH163_RS05745	COG2357	RelA SpoT domain protein
EH163_RS05765	COG0789	Transcriptional regulator
EH163_RS05770	COG2271	Major facilitator Superfamily
EH163_RS05775	COG1802	Transcriptional regulator
EH163_RS05785	COG2610	gluconate transmembrane transporter activity
EH163_RS05790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EH163_RS05795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EH163_RS05800	COG0438	transferase activity, transferring glycosyl groups
EH163_RS05805	COG0494	nUDIX hydrolase
EH163_RS05810	COG0556	nucleotide-excision repair
EH163_RS05825	COG4221	oxidoreductase activity
EH163_RS05830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH163_RS05835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EH163_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS05855	COG1363	Peptidase, m42
EH163_RS05865	COG0069	glutamate synthase activity
EH163_RS05890	COG4619	ABC transporter
EH163_RS05895	COG0390	transport system, permease component
EH163_RS05900	COG2814	Major facilitator Superfamily
EH163_RS05905	COG2272	Belongs to the type-B carboxylesterase lipase family
EH163_RS05910	COG0531	amino acid
EH163_RS05915	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
EH163_RS05920	COG1063	alcohol dehydrogenase
EH163_RS05940	COG1174	glycine betaine transport
EH163_RS05945	COG1346	cytolysis
EH163_RS05950	COG1380	Effector of murein hydrolase LrgA
EH163_RS05955	COG3279	Response regulator of the LytR AlgR family
EH163_RS05960	COG3275	phosphorelay sensor kinase activity
EH163_RS05970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EH163_RS05975	COG0706	membrane insertase activity
EH163_RS05985	COG0531	amino acid
EH163_RS05990	COG1113	amino acid transport
EH163_RS06015	COG1929	Belongs to the glycerate kinase type-1 family
EH163_RS06030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EH163_RS06035	COG0588	phosphoglycerate mutase activity
EH163_RS06045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EH163_RS06050	COG0765	amino acid transport
EH163_RS06055	COG1126	abc transporter atp-binding protein
EH163_RS06060	COG2348	transferase activity, transferring amino-acyl groups
EH163_RS06080	COG2116	formate transmembrane transporter activity
EH163_RS06085	COG0454	-acetyltransferase
EH163_RS06090	COG0747	negative chemotaxis
EH163_RS06105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EH163_RS06110	COG2146	nitrite reductase [NAD(P)H] activity
EH163_RS06120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EH163_RS06125	COG1140	nitrate reductase beta subunit
EH163_RS06135	COG2181	nitrate reductase activity
EH163_RS06145	COG4585	Histidine kinase
EH163_RS06150	COG2197	response regulator
EH163_RS06155	COG2223	nitrite transmembrane transporter activity
EH163_RS06160	COG1846	Transcriptional regulator
EH163_RS06165	COG0778	Nitroreductase
EH163_RS06185	COG3871	stress protein (general stress protein 26)
EH163_RS06200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH163_RS06200	COG1263	PTS System
EH163_RS06245	COG0604	alcohol dehydrogenase
EH163_RS06250	COG0456	acetyltransferase
EH163_RS06255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EH163_RS06255	COG0463	Glycosyl transferase, family 2
EH163_RS06265	COG0463	Glycosyl transferase, family 2
EH163_RS06265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EH163_RS06270	COG1620	l-lactate permease
EH163_RS06275	COG0438	transferase activity, transferring glycosyl groups
EH163_RS06280	COG0579	oxidoreductase
EH163_RS06285	COG3850	Histidine kinase
EH163_RS06285	COG5002	protein histidine kinase activity
EH163_RS06290	COG0745	RESPONSE REGULATOR receiver
EH163_RS06295	COG0577	efflux transmembrane transporter activity
EH163_RS06300	COG1136	(ABC) transporter
EH163_RS06315	COG4640	response to antibiotic
EH163_RS06320	COG2814	Major facilitator Superfamily
EH163_RS06330	COG1566	PFAM secretion protein HlyD family protein
EH163_RS06335	COG2814	Major facilitator Superfamily
EH163_RS06350	COG0657	acetylesterase activity
EH163_RS06365	COG0598	Magnesium transport protein CorA
EH163_RS06370	COG1304	FMN binding
EH163_RS06375	COG0786	glutamate:sodium symporter activity
EH163_RS06395	COG2094	Belongs to the DNA glycosylase MPG family
EH163_RS06420	COG1069	ribulokinase activity
EH163_RS06425	COG2017	converts alpha-aldose to the beta-anomer
EH163_RS06430	COG2258	MOSC domain
EH163_RS06435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EH163_RS06450	COG1266	CAAX protease self-immunity
EH163_RS06455	COG0010	Belongs to the arginase family
EH163_RS06460	COG1473	amidohydrolase
EH163_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS06470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EH163_RS06495	COG1737	Transcriptional regulator
EH163_RS06500	COG1263	PTS System
EH163_RS06500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH163_RS06510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EH163_RS06530	COG1113	amino acid transport
EH163_RS06540	COG1263	PTS System
EH163_RS06540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH163_RS06545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EH163_RS06560	COG1266	CAAX protease self-immunity
EH163_RS06565	COG2378	regulation of single-species biofilm formation
EH163_RS06570	COG0483	inositol monophosphate 1-phosphatase activity
EH163_RS06575	COG1316	TRANSCRIPTIONal
EH163_RS06600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EH163_RS06605	COG2076	Multidrug Resistance protein
EH163_RS06610	COG2076	Multidrug Resistance protein
EH163_RS06615	COG3942	CHAP domain
EH163_RS06630	COG1757	Na H antiporter
EH163_RS06635	COG3942	CHAP domain
EH163_RS06660	COG0829	nickel cation binding
EH163_RS06665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EH163_RS06670	COG0830	nickel cation binding
EH163_RS06675	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EH163_RS06680	COG0804	urea catabolic process
EH163_RS06685	COG0832	Belongs to the urease beta subunit family
EH163_RS06690	COG0831	urea catabolic process
EH163_RS06705	COG1960	acyl-CoA dehydrogenase activity
EH163_RS06710	COG1957	nucleoside hydrolase
EH163_RS06715	COG1268	BioY protein
EH163_RS06725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EH163_RS06735	COG0725	ABC transporter, periplasmic molybdate-binding protein
EH163_RS06740	COG4149	molybdate abc transporter
EH163_RS06745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EH163_RS06750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EH163_RS06755	COG0521	Mo-molybdopterin cofactor biosynthetic process
EH163_RS06760	COG0315	cyclic pyranopterin monophosphate synthase activity
EH163_RS06765	COG0303	'Molybdopterin
EH163_RS06775	COG0314	molybdopterin synthase activity
EH163_RS06785	COG0746	molybdenum cofactor guanylyltransferase activity
EH163_RS06790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EH163_RS06815	COG2814	Major facilitator Superfamily
EH163_RS06830	COG2348	transferase activity, transferring amino-acyl groups
EH163_RS06835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EH163_RS06855	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS06860	COG4975	Glucose uptake
EH163_RS06865	COG0551	DNA topoisomerase type I activity
EH163_RS06865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EH163_RS06870	COG2252	PERMEase
EH163_RS06885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EH163_RS06890	COG0088	Forms part of the polypeptide exit tunnel
EH163_RS06895	COG0089	rRNA binding
EH163_RS06900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EH163_RS06905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EH163_RS06910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EH163_RS06915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EH163_RS06920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EH163_RS06930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EH163_RS06935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EH163_RS06940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EH163_RS06945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EH163_RS06950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EH163_RS06955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EH163_RS06960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EH163_RS06965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EH163_RS06970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EH163_RS06975	COG1841	ribosomal large subunit assembly
EH163_RS06980	COG0200	Binds to the 23S rRNA
EH163_RS06985	COG0201	protein transport
EH163_RS06990	COG0563	adenylate kinase activity
EH163_RS06995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EH163_RS07000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EH163_RS07005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EH163_RS07010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EH163_RS07015	COG0202	RNA polymerase activity
EH163_RS07020	COG0203	ribosomal protein L17
EH163_RS07025	COG1122	ATPase activity
EH163_RS07030	COG1122	ATPase activity
EH163_RS07040	COG0101	tRNA pseudouridine synthase activity
EH163_RS07045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EH163_RS07050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EH163_RS07055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EH163_RS07060	COG1349	DNA-binding transcription factor activity
EH163_RS07065	COG0698	ribose 5-phosphate isomerase
EH163_RS07070	COG0698	ribose 5-phosphate isomerase
EH163_RS07075	COG1105	Belongs to the carbohydrate kinase PfkB family
EH163_RS07080	COG3684	Belongs to the aldolase LacD family
EH163_RS07085	COG1447	Phosphotransferase system cellobiose-specific component IIA
EH163_RS07090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EH163_RS07090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EH163_RS07095	COG2723	6-phospho-beta-galactosidase activity
EH163_RS07105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EH163_RS07110	COG2130	NADP-dependent
EH163_RS07115	COG0604	alcohol dehydrogenase
EH163_RS07130	COG1302	Protein conserved in bacteria
EH163_RS07135	COG4264	IucA IucC family
EH163_RS07140	COG2814	Major facilitator Superfamily
EH163_RS07145	COG4264	IucA IucC family
EH163_RS07150	COG3457	Alanine racemase
EH163_RS07155	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EH163_RS07160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EH163_RS07165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EH163_RS07170	COG3314	Sporulation integral membrane protein YlbJ
EH163_RS07175	COG2329	Antibiotic biosynthesis monooxygenase
EH163_RS07185	COG1988	membrane-bound metal-dependent
EH163_RS07190	COG4284	Utp--glucose-1-phosphate uridylyltransferase
EH163_RS07210	COG2814	Major facilitator Superfamily
EH163_RS07215	COG0489	protein tyrosine kinase activity
EH163_RS07265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EH163_RS07275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EH163_RS07280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EH163_RS07285	COG0561	phosphatase activity
EH163_RS07305	COG0640	Transcriptional regulator
EH163_RS07310	COG0702	epimerase
EH163_RS07320	COG1482	cell wall glycoprotein biosynthetic process
EH163_RS07345	COG0783	Belongs to the Dps family
EH163_RS07350	COG0813	purine-nucleoside phosphorylase activity
EH163_RS07355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EH163_RS07360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EH163_RS07365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EH163_RS07375	COG1854	S-ribosylhomocysteine lyase activity
EH163_RS07395	COG5146	pantothenate kinase activity
EH163_RS07405	COG3343	RNA polymerase activity
EH163_RS07410	COG0504	CTP synthase activity
EH163_RS07420	COG0191	fructose-bisphosphate aldolase activity
EH163_RS07425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EH163_RS07435	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS07440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EH163_RS07445	COG0254	rRNA binding
EH163_RS07455	COG1435	thymidine kinase activity
EH163_RS07460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EH163_RS07465	COG2890	protein-(glutamine-N5) methyltransferase activity
EH163_RS07475	COG0009	L-threonylcarbamoyladenylate synthase
EH163_RS07480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH163_RS07485	COG4475	Protein of unknown function (DUF436)
EH163_RS07490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EH163_RS07495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EH163_RS07500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EH163_RS07510	COG0356	it plays a direct role in the translocation of protons across the membrane
EH163_RS07520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EH163_RS07525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EH163_RS07530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EH163_RS07535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EH163_RS07540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EH163_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EH163_RS07555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EH163_RS07560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EH163_RS07570	COG0629	single-stranded DNA binding
EH163_RS07575	COG1388	LysM domain
EH163_RS07580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EH163_RS07590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EH163_RS07595	COG0352	thiamine-phosphate diphosphorylase activity
EH163_RS07600	COG0706	membrane insertase activity
EH163_RS07605	COG1418	mRNA catabolic process
EH163_RS07610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EH163_RS07615	COG1937	Protein conserved in bacteria
EH163_RS07635	COG1181	Belongs to the D-alanine--D-alanine ligase family
EH163_RS07640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EH163_RS07645	COG0513	Belongs to the DEAD box helicase family
EH163_RS07655	COG3428	Bacterial PH domain
EH163_RS07660	COG3402	PFAM membrane-flanked domain
EH163_RS07665	COG0736	holo-[acyl-carrier-protein] synthase activity
EH163_RS07670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EH163_RS07680	COG2337	Toxic component of a toxin-antitoxin (TA) module
EH163_RS07685	COG2208	phosphoserine phosphatase activity
EH163_RS07700	COG1191	sigma factor activity
EH163_RS07705	COG2183	response to ionizing radiation
EH163_RS07710	COG3091	SprT-like family
EH163_RS07750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EH163_RS07755	COG0066	3-isopropylmalate dehydratase activity
EH163_RS07760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EH163_RS07765	COG0473	3-isopropylmalate dehydrogenase activity
EH163_RS07770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EH163_RS07775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EH163_RS07785	COG0028	Belongs to the TPP enzyme family
EH163_RS07790	COG0129	dihydroxy-acid dehydratase activity
EH163_RS07795	COG0802	atpase or kinase
EH163_RS07800	COG1214	PFAM Peptidase M22, glycoprotease
EH163_RS07805	COG0456	acetyltransferase
EH163_RS07810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EH163_RS07815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EH163_RS07820	COG0488	(ABC) transporter
EH163_RS07825	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EH163_RS07835	COG2391	methyltransferase activity
EH163_RS07840	COG0425	Belongs to the sulfur carrier protein TusA family
EH163_RS07845	COG0004	ammonium transporteR
EH163_RS07850	COG1609	Transcriptional regulator
EH163_RS07860	COG1621	beta-fructofuranosidase activity
EH163_RS07865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EH163_RS07870	COG3279	Response regulator of the LytR AlgR family
EH163_RS07910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EH163_RS07915	COG0459	protein refolding
EH163_RS07920	COG0582	viral genome integration into host DNA
EH163_RS08070	COG1725	Transcriptional regulator
EH163_RS08075	COG1131	(ABC) transporter
EH163_RS08085	COG1131	(ABC) transporter
EH163_RS08135	COG4974	Belongs to the 'phage' integrase family
EH163_RS08165	COG3682	Transcriptional regulator
EH163_RS08175	COG2706	6-phosphogluconolactonase activity
EH163_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
EH163_RS08185	COG1227	inorganic diphosphatase activity
EH163_RS08190	COG1335	isochorismatase
EH163_RS08200	COG0077	Prephenate dehydratase
EH163_RS08210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EH163_RS08215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EH163_RS08220	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EH163_RS08230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EH163_RS08235	COG4496	protein, YerC YecD
EH163_RS08240	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EH163_RS08245	COG0210	DNA helicase
EH163_RS08250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EH163_RS08255	COG4851	CamS sex pheromone cAM373 precursor
EH163_RS08260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EH163_RS08265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EH163_RS08270	COG0154	amidase activity
EH163_RS08275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EH163_RS08280	COG1597	lipid kinase activity
EH163_RS08285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EH163_RS08295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EH163_RS08305	COG1528	Iron-storage protein
EH163_RS08325	COG4129	membrane
EH163_RS08330	COG0024	Methionine aminopeptidase
EH163_RS08345	COG4585	Histidine kinase
EH163_RS08350	COG2197	response regulator
EH163_RS08355	COG1295	ribonuclease BN
EH163_RS08365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EH163_RS08370	COG4840	Belongs to the UPF0435 family
EH163_RS08375	COG2309	aminopeptidase activity
EH163_RS08380	COG1607	acyl-coa hydrolase
EH163_RS08385	COG0535	radical SAM domain protein
EH163_RS08395	COG0693	protein deglycase activity
EH163_RS08400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EH163_RS08405	COG2137	regulation of response to DNA damage stimulus
EH163_RS08415	COG1388	LysM domain
EH163_RS08415	COG1134	teichoic acid transport
EH163_RS08425	COG1988	membrane-bound metal-dependent
EH163_RS08435	COG3557	Belongs to the UPF0374 family
EH163_RS08445	COG4129	membrane
EH163_RS08450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EH163_RS08455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EH163_RS08460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EH163_RS08465	COG0735	belongs to the Fur family
EH163_RS08625	COG0765	amino acid transport
EH163_RS08630	COG1126	abc transporter atp-binding protein
EH163_RS08635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EH163_RS08660	COG0114	fumarate hydratase activity
EH163_RS08680	COG2203	Gaf domain
EH163_RS08680	COG4585	Histidine kinase
EH163_RS08685	COG2197	response regulator
EH163_RS08700	COG3679	Belongs to the UPF0342 family
EH163_RS08705	COG0420	3'-5' exonuclease activity
EH163_RS08715	COG3481	metal-dependent phosphohydrolase, HD sub domain
EH163_RS08725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EH163_RS08740	COG0537	adenosine 5'-monophosphoramidase activity
EH163_RS08745	COG1131	(ABC) transporter
EH163_RS08750	COG4473	ABC transporter
EH163_RS08760	COG2329	Antibiotic biosynthesis monooxygenase
EH163_RS08765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EH163_RS08770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EH163_RS08775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EH163_RS08875	COG0318	PFAM AMP-dependent synthetase and ligase
EH163_RS08885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EH163_RS08890	COG0494	nUDIX hydrolase
EH163_RS08895	COG1506	peptidase
EH163_RS08900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EH163_RS08905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EH163_RS08915	COG0656	L-ascorbic acid biosynthetic process
EH163_RS08920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EH163_RS08925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EH163_RS08935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EH163_RS08965	COG3266	domain, Protein
EH163_RS08965	COG4193	domain, Protein
EH163_RS08965	COG5632	N-Acetylmuramoyl-L-alanine amidase
EH163_RS08975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EH163_RS08975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EH163_RS08985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EH163_RS08985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EH163_RS08990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EH163_RS08995	COG0506	proline dehydrogenase activity
EH163_RS09000	COG2267	carboxylic ester hydrolase activity
EH163_RS09020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EH163_RS09025	COG1242	4 iron, 4 sulfur cluster binding
EH163_RS09030	COG2814	Major facilitator Superfamily
EH163_RS09035	COG0495	leucyl-tRNA aminoacylation
EH163_RS09050	COG2081	HI0933 family
EH163_RS09055	COG2244	polysaccharide biosynthetic process
EH163_RS09060	COG1187	pseudouridine synthase activity
EH163_RS09070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EH163_RS09075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EH163_RS09080	COG0510	thiamine kinase activity
EH163_RS09085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EH163_RS09095	COG1363	Peptidase, m42
EH163_RS09100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EH163_RS09105	COG4848	Belongs to the UPF0354 family
EH163_RS09110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EH163_RS09115	COG1674	ftsk spoiiie
EH163_RS09120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EH163_RS09125	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
EH163_RS09135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EH163_RS09135	COG1605	Chorismate mutase
EH163_RS09140	COG1609	Transcriptional regulator
EH163_RS09145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EH163_RS09155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EH163_RS09160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EH163_RS09165	COG0204	Acyl-transferase
EH163_RS09170	COG1263	PTS System
EH163_RS09170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EH163_RS09180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EH163_RS09185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EH163_RS09190	COG1764	response to oxidative stress
EH163_RS09195	COG0584	glycerophosphoryl diester phosphodiesterase
EH163_RS09200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EH163_RS09210	COG1956	GAF domain-containing protein
EH163_RS09215	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EH163_RS09225	COG0301	tRNA thio-modification
EH163_RS09235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EH163_RS09240	COG0827	DNA restriction-modification system
EH163_RS09245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EH163_RS09250	COG0589	response to stress
EH163_RS09255	COG0686	Belongs to the AlaDH PNT family
EH163_RS09260	COG0006	proline dipeptidase activity
EH163_RS09265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EH163_RS09275	COG4109	DRTGG domain
EH163_RS09280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EH163_RS09285	COG0587	DNA-directed DNA polymerase activity
EH163_RS09290	COG0281	malic enzyme
EH163_RS09295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EH163_RS09300	COG0825	malonyl-CoA metabolic process
EH163_RS09305	COG0205	6-phosphofructokinase activity
EH163_RS09310	COG0469	pyruvate kinase activity
EH163_RS09315	COG1113	amino acid transport
EH163_RS09320	COG0372	Belongs to the citrate synthase family
EH163_RS09325	COG0538	isocitrate dehydrogenase activity
EH163_RS09330	COG0745	RESPONSE REGULATOR receiver
EH163_RS09335	COG5002	protein histidine kinase activity
EH163_RS09340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EH163_RS09340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EH163_RS09345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EH163_RS09350	COG0237	dephospho-CoA kinase activity
EH163_RS09360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EH163_RS09370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EH163_RS09375	COG3611	Membrane attachment protein
EH163_RS09380	COG1484	DNA-dependent DNA replication
EH163_RS09385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EH163_RS09390	COG0833	amino acid
EH163_RS09395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EH163_RS09400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EH163_RS09405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EH163_RS09410	COG4112	unkown
EH163_RS09420	COG0544	peptidyl-prolyl cis-trans isomerase activity
EH163_RS09425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EH163_RS09430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EH163_RS09435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EH163_RS09445	COG0181	hydroxymethylbilane synthase activity
EH163_RS09455	COG0113	porphobilinogen synthase activity
EH163_RS09460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EH163_RS09470	COG2818	Glycosylase
EH163_RS09475	COG0525	valine-tRNA ligase activity
EH163_RS09480	COG0285	dihydrofolate synthase activity
EH163_RS09490	COG2003	Belongs to the UPF0758 family
EH163_RS09520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EH163_RS09525	COG2868	ribosomal protein
EH163_RS09530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EH163_RS09535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EH163_RS09540	COG4492	Belongs to the UPF0735 family
EH163_RS09545	COG0632	four-way junction helicase activity
EH163_RS09550	COG2255	four-way junction helicase activity
EH163_RS09555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EH163_RS09560	COG0343	queuine tRNA-ribosyltransferase activity
EH163_RS09565	COG1862	Preprotein translocase
EH163_RS09570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EH163_RS09570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EH163_RS09575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EH163_RS09575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EH163_RS09580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EH163_RS09590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EH163_RS09595	COG1490	D-aminoacyl-tRNA deacylase activity
EH163_RS09600	COG0860	N-Acetylmuramoyl-L-alanine amidase
EH163_RS09605	COG0124	histidyl-tRNA synthetase
EH163_RS09610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EH163_RS09620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EH163_RS09625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EH163_RS09630	COG1959	2 iron, 2 sulfur cluster binding
EH163_RS09640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EH163_RS09645	COG1104	cysteine desulfurase activity
EH163_RS09650	COG0482	sulfurtransferase activity
EH163_RS09660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EH163_RS09665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EH163_RS09670	COG4472	Bacterial protein of unknown function (DUF965)
EH163_RS09675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EH163_RS09680	COG3906	Belongs to the UPF0473 family
EH163_RS09690	COG0826	peptidase U32
EH163_RS09695	COG0826	peptidase U32
EH163_RS09700	COG0572	uridine kinase
EH163_RS09705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EH163_RS09715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EH163_RS09720	COG1984	allophanate hydrolase subunit 2
EH163_RS09725	COG0511	ligase activity, forming carbon-carbon bonds
EH163_RS09730	COG0439	Biotin carboxylase
EH163_RS09735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EH163_RS09740	COG1914	H( )-stimulated, divalent metal cation uptake system
EH163_RS09745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EH163_RS09750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EH163_RS09755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EH163_RS09760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EH163_RS09765	COG1534	Rna-binding protein
EH163_RS09770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EH163_RS09775	COG1713	HD superfamily hydrolase involved in NAD metabolism
EH163_RS09780	COG0799	negative regulation of ribosome biogenesis
EH163_RS09785	COG2226	methyltransferase
EH163_RS09795	COG2131	deaminase
EH163_RS09800	COG0658	competence protein
EH163_RS09800	COG2333	competence protein COMEC
EH163_RS09805	COG1466	dna polymerase III delta subunit
EH163_RS09815	COG0268	Binds directly to 16S ribosomal RNA
EH163_RS09820	COG0481	GTPase activity
EH163_RS09825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EH163_RS09830	COG1420	regulation of RNA biosynthetic process
EH163_RS09835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EH163_RS09840	COG0443	Heat shock 70 kDa protein
EH163_RS09845	COG0484	heat shock protein binding
EH163_RS09850	COG2264	protein methyltransferase activity
EH163_RS09855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EH163_RS09860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EH163_RS09870	COG1030	water channel activity
EH163_RS09875	COG4864	UPF0365 protein
EH163_RS09885	COG1702	phosphate starvation-inducible protein PhoH
EH163_RS09890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EH163_RS09895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EH163_RS09905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EH163_RS09910	COG1381	Involved in DNA repair and RecF pathway recombination
EH163_RS09915	COG0423	glycine-tRNA ligase activity
EH163_RS09920	COG0517	IMP dehydrogenase activity
EH163_RS09925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EH163_RS09930	COG0358	DNA primase activity
EH163_RS09935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EH163_RS09940	COG2384	SAM-dependent methyltransferase
EH163_RS09945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EH163_RS09950	COG0513	Belongs to the DEAD box helicase family
EH163_RS09955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EH163_RS09960	COG1121	(ABC) transporter
EH163_RS09965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EH163_RS09970	COG0735	belongs to the Fur family
EH163_RS09975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EH163_RS09985	COG0768	penicillin binding
EH163_RS09990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EH163_RS09995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EH163_RS10005	COG4483	Protein conserved in bacteria
EH163_RS10010	COG1940	carbohydrate kinase activity
EH163_RS10015	COG0011	TIGRFAM Protein of
EH163_RS10025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EH163_RS10030	COG1459	type II secretion system
EH163_RS10035	COG4537	Required for transformation and DNA binding
EH163_RS10060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EH163_RS10065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EH163_RS10070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EH163_RS10075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EH163_RS10085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EH163_RS10090	COG0095	Lipoate-protein ligase
EH163_RS10105	COG0006	proline dipeptidase activity
EH163_RS10110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EH163_RS10115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EH163_RS10120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EH163_RS10125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EH163_RS10130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EH163_RS10135	COG0511	ligase activity, forming carbon-carbon bonds
EH163_RS10140	COG0439	Biotin carboxylase
EH163_RS10145	COG1302	Protein conserved in bacteria
EH163_RS10150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EH163_RS10155	COG1570	exodeoxyribonuclease VII activity
EH163_RS10160	COG1722	exodeoxyribonuclease VII activity
EH163_RS10170	COG1438	arginine binding
EH163_RS10175	COG0497	DNA recombination
EH163_RS10180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EH163_RS10185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EH163_RS10190	COG0022	dehydrogenase e1 component
EH163_RS10195	COG0508	dehydrogenase complex catalyzes the overall conversion of
EH163_RS10205	COG4129	membrane
EH163_RS10210	COG2195	Cleaves the N-terminal amino acid of tripeptides
EH163_RS10215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EH163_RS10220	COG0366	Alpha amylase catalytic
EH163_RS10235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EH163_RS10240	COG1234	tRNA 3'-trailer cleavage
EH163_RS10245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EH163_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS10255	COG0667	Aldo Keto reductase
EH163_RS10260	COG0494	nUDIX hydrolase
EH163_RS10265	COG0735	belongs to the Fur family
EH163_RS10270	COG4974	Belongs to the 'phage' integrase family
EH163_RS10275	COG1547	Domain of unknown function (DUF309)
EH163_RS10280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EH163_RS10285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EH163_RS10290	COG1187	pseudouridine synthase activity
EH163_RS10295	COG0745	RESPONSE REGULATOR receiver
EH163_RS10315	COG1141	Ferredoxin
EH163_RS10325	COG0514	ATP-dependent DNA helicase (RecQ)
EH163_RS10330	COG1388	LysM domain
EH163_RS10335	COG0492	ferredoxin-NADP+ reductase activity
EH163_RS10340	COG0252	asparaginase activity
EH163_RS10345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EH163_RS10350	COG0539	negative regulation of cytoplasmic translation
EH163_RS10355	COG1160	GTP binding
EH163_RS10360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EH163_RS10375	COG2226	methyltransferase
EH163_RS10385	COG0105	UTP biosynthetic process
EH163_RS10390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EH163_RS10395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EH163_RS10400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EH163_RS10410	COG5582	Belongs to the UPF0302 family
EH163_RS10415	COG4347	Protein of unknown function (DUF1405)
EH163_RS10420	COG2738	Putative neutral zinc metallopeptidase
EH163_RS10425	COG1694	Mazg nucleotide pyrophosphohydrolase
EH163_RS10430	COG0438	transferase activity, transferring glycosyl groups
EH163_RS10435	COG0617	tRNA 3'-terminal CCA addition
EH163_RS10440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EH163_RS10440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EH163_RS10445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EH163_RS10445	COG1199	ATP-dependent helicase activity
EH163_RS10450	COG0017	Asparaginyl-tRNA synthetase
EH163_RS10455	COG3935	DnaD domain protein
EH163_RS10460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EH163_RS10470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EH163_RS10470	COG4499	WXG100 protein secretion system (Wss), protein YukC
EH163_RS10475	COG3331	DNA recombination
EH163_RS10485	COG4474	Belongs to the UPF0398 family
EH163_RS10490	COG3599	regulation of cell shape
EH163_RS10500	COG0116	Belongs to the methyltransferase superfamily
EH163_RS10510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EH163_RS10515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EH163_RS10520	COG4372	Transposase
EH163_RS10520	COG1511	domain protein
EH163_RS10520	COG1196	nuclear chromosome segregation
EH163_RS10530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EH163_RS10540	COG1413	lyase activity
EH163_RS10555	COG1136	(ABC) transporter
EH163_RS10580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EH163_RS10585	COG2190	(PTS) system
EH163_RS10590	COG4479	Belongs to the UPF0346 family
EH163_RS10595	COG0793	Belongs to the peptidase S41A family
EH163_RS10610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EH163_RS10615	COG0671	phosphoesterase, PA-phosphatase related
EH163_RS10630	COG0745	RESPONSE REGULATOR receiver
EH163_RS10635	COG5002	protein histidine kinase activity
EH163_RS10645	COG0567	Dehydrogenase, E1 component
EH163_RS10650	COG0508	dehydrogenase complex catalyzes the overall conversion of
EH163_RS10670	COG0714	Associated with various cellular activities
EH163_RS10675	COG4548	von Willebrand factor, type A
EH163_RS10680	COG1114	Component of the transport system for branched-chain amino acids
EH163_RS10685	COG3853	Toxic anion resistance protein (TelA)
EH163_RS10695	COG1254	Belongs to the acylphosphatase family
EH163_RS10705	COG1278	Cold shock
EH163_RS10720	COG1131	(ABC) transporter
EH163_RS10740	COG1473	amidohydrolase
EH163_RS10745	COG2171	N-acyltransferase activity
EH163_RS10750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EH163_RS10755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EH163_RS10760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EH163_RS10765	COG0527	aspartate kinase activity
EH163_RS10770	COG0488	(ABC) transporter
EH163_RS10775	COG2996	Protein conserved in bacteria
EH163_RS10780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EH163_RS10785	COG0573	inorganic phosphate transmembrane transporter activity
EH163_RS10790	COG0581	inorganic phosphate transmembrane transporter activity
EH163_RS10795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EH163_RS10800	COG0704	Plays a role in the regulation of phosphate uptake
EH163_RS10840	COG2348	transferase activity, transferring amino-acyl groups
EH163_RS10845	COG2348	transferase activity, transferring amino-acyl groups
EH163_RS10860	COG0159	tryptophan synthase activity
EH163_RS10865	COG0133	tryptophan synthase activity
EH163_RS10870	COG0135	phosphoribosylanthranilate isomerase activity
EH163_RS10875	COG0134	indole-3-glycerol-phosphate synthase activity
EH163_RS10880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EH163_RS10885	COG0512	Glutamine amidotransferase of anthranilate synthase
EH163_RS10885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EH163_RS10890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EH163_RS10895	COG0287	Prephenate dehydrogenase
EH163_RS10900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EH163_RS10905	COG1942	4-Oxalocrotonate Tautomerase
EH163_RS10925	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EH163_RS10925	COG0392	lysyltransferase activity
EH163_RS10930	COG0628	permease
EH163_RS10935	COG3711	transcriptional antiterminator
EH163_RS10940	COG1115	amino acid carrier protein
EH163_RS10945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EH163_RS10950	COG0187	DNA topoisomerase II activity
EH163_RS10955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EH163_RS10960	COG4841	protein insertion into membrane
EH163_RS10965	COG0824	Thioesterase
EH163_RS10970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EH163_RS10975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EH163_RS10980	COG1970	mechanosensitive ion channel activity
EH163_RS10985	COG0419	ATPase involved in DNA repair
EH163_RS10990	COG0420	3'-5' exonuclease activity
EH163_RS10995	COG4846	Membrane protein involved in cytochrome C biogenesis
EH163_RS11005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EH163_RS11010	COG4224	UPF0291 protein
EH163_RS11020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EH163_RS11030	COG2340	Cysteine-rich secretory protein family
EH163_RS11035	COG0516	GMP reductase activity
EH163_RS11040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EH163_RS11050	COG0753	catalase activity
EH163_RS11055	COG0833	amino acid
EH163_RS11070	COG0083	homoserine kinase activity
EH163_RS11075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EH163_RS11080	COG0460	homoserine dehydrogenase
EH163_RS11085	COG0527	aspartate kinase activity
EH163_RS11105	COG1525	nuclease
EH163_RS11115	COG2197	response regulator
EH163_RS11120	COG4585	Histidine kinase
EH163_RS11130	COG1131	(ABC) transporter
EH163_RS11135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EH163_RS11180	COG0174	glutamine synthetase
EH163_RS11185	COG0789	Transcriptional regulator
EH163_RS11190	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EH163_RS11195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EH163_RS11200	COG0386	Belongs to the glutathione peroxidase family
EH163_RS11205	COG1923	regulation of RNA biosynthetic process
EH163_RS11210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EH163_RS11220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EH163_RS11225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EH163_RS11230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EH163_RS11235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EH163_RS11240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EH163_RS11245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EH163_RS11255	COG4550	Control of competence regulator ComK, YlbF/YmcA
EH163_RS11260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EH163_RS11270	COG4195	phage-related replication protein
EH163_RS11275	COG1013	pyruvate-flavodoxin oxidoreductase activity
EH163_RS11280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EH163_RS11280	COG0674	pyruvate-flavodoxin oxidoreductase activity
EH163_RS11285	COG1692	metallophosphoesterase
EH163_RS11295	COG1418	mRNA catabolic process
EH163_RS11300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EH163_RS11305	COG1058	Belongs to the CinA family
EH163_RS11305	COG1546	Belongs to the CinA family
EH163_RS11310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EH163_RS11325	COG0300	oxidoreductase activity
EH163_RS11330	COG0612	Peptidase, M16
EH163_RS11335	COG0612	Peptidase, M16
EH163_RS11340	COG2188	Transcriptional regulator
EH163_RS11345	COG1674	ftsk spoiiie
EH163_RS11350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EH163_RS11355	COG1185	polyribonucleotide nucleotidyltransferase activity
EH163_RS11360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EH163_RS11365	COG0196	riboflavin kinase activity
EH163_RS11370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EH163_RS11375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EH163_RS11380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EH163_RS11385	COG1358	cellular component organization or biogenesis
EH163_RS11390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EH163_RS11395	COG0195	Participates in both transcription termination and antitermination
EH163_RS11400	COG0779	Required for maturation of 30S ribosomal subunits
EH163_RS11405	COG2176	DNA-directed DNA polymerase activity
EH163_RS11410	COG0442	prolyl-tRNA aminoacylation
EH163_RS11420	COG4589	Belongs to the CDS family
EH163_RS11425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EH163_RS11430	COG0233	cytoplasmic translational termination
EH163_RS11435	COG0528	UMP kinase activity
EH163_RS11440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EH163_RS11445	COG0052	Belongs to the universal ribosomal protein uS2 family
EH163_RS11450	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EH163_RS11455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EH163_RS11460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EH163_RS11465	COG4974	Belongs to the 'phage' integrase family
EH163_RS11470	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EH163_RS11475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EH163_RS11480	COG0758	DNA mediated transformation
EH163_RS11485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EH163_RS11490	COG0045	succinate-CoA ligase (ADP-forming) activity
EH163_RS11495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EH163_RS11510	COG4485	Bacterial membrane protein, YfhO
EH163_RS11520	COG0335	large ribosomal subunit rRNA binding
EH163_RS11525	COG0336	Belongs to the RNA methyltransferase TrmD family
EH163_RS11530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EH163_RS11535	COG0228	four-way junction DNA binding
EH163_RS11540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EH163_RS11545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EH163_RS11550	COG0552	protein localization to endoplasmic reticulum
EH163_RS11555	COG1196	nuclear chromosome segregation
EH163_RS11560	COG0571	ribonuclease III activity
EH163_RS11565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EH163_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
EH163_RS11580	COG0416	fatty acid biosynthetic process
EH163_RS11585	COG1349	DNA-binding transcription factor activity
EH163_RS11590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EH163_RS11595	COG1461	Dihydroxyacetone kinase
EH163_RS11600	COG1302	Protein conserved in bacteria
EH163_RS11605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EH163_RS11615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EH163_RS11620	COG1162	GTPase activity
EH163_RS11630	COG0631	protein serine/threonine phosphatase activity
EH163_RS11635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EH163_RS11640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EH163_RS11640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EH163_RS11645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EH163_RS11650	COG0242	peptide deformylase activity
EH163_RS11660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EH163_RS11665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EH163_RS11670	COG1758	RNA polymerase activity
EH163_RS11675	COG0194	GDP metabolic process
EH163_RS11695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EH163_RS11700	COG0284	orotidine-5'-phosphate decarboxylase activity
EH163_RS11705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EH163_RS11710	COG0505	Belongs to the CarA family
EH163_RS11715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EH163_RS11720	COG0540	Belongs to the ATCase OTCase family
EH163_RS11725	COG2233	PERMEase
EH163_RS11730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EH163_RS11735	COG0564	pseudouridine synthase activity
EH163_RS11740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EH163_RS11745	COG1388	LysM domain
EH163_RS11745	COG3942	CHAP domain
EH163_RS11755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EH163_RS11760	COG3599	regulation of cell shape
EH163_RS11770	COG0762	integral membrane protein
EH163_RS11775	COG1799	cell septum assembly
EH163_RS11780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EH163_RS11785	COG1496	oxidoreductase activity
EH163_RS11795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EH163_RS11800	COG0849	cell division
EH163_RS11805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EH163_RS11810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EH163_RS11815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EH163_RS11820	COG0768	penicillin binding
EH163_RS11825	COG4839	cell division protein FtsL
EH163_RS11830	COG0275	rRNA processing
EH163_RS11835	COG2001	Belongs to the MraZ family
EH163_RS11840	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EH163_RS11845	COG0454	-acetyltransferase
EH163_RS11850	COG1011	Hydrolase
EH163_RS11885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EH163_RS11890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EH163_RS11895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EH163_RS11900	COG1053	succinate dehydrogenase
EH163_RS11905	COG2009	succinate dehydrogenase
EH163_RS11915	COG0322	excinuclease ABC activity
EH163_RS11920	COG3118	belongs to the thioredoxin family
EH163_RS11925	COG1193	negative regulation of DNA recombination
EH163_RS11930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EH163_RS11930	COG1796	DNA polymerase
EH163_RS11940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EH163_RS11945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EH163_RS11950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EH163_RS11950	COG0072	phenylalanine-tRNA ligase activity
EH163_RS11955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EH163_RS11960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EH163_RS11975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EH163_RS11990	COG1323	Belongs to the UPF0348 family
EH163_RS11995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EH163_RS12000	COG0742	ribosomal rna small subunit methyltransferase
EH163_RS12010	COG4471	UPF0298 protein
EH163_RS12020	COG0584	glycerophosphoryl diester phosphodiesterase
EH163_RS12025	COG3679	Belongs to the UPF0342 family
EH163_RS12030	COG2340	Cysteine-rich secretory protein family
EH163_RS12040	COG0109	protoheme IX farnesyltransferase activity
EH163_RS12045	COG1612	heme a metabolic process
EH163_RS12055	COG0772	Belongs to the SEDS family
EH163_RS12060	COG4838	Belongs to the UPF0358 family
EH163_RS12065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EH163_RS12070	COG4896	Protein conserved in bacteria
EH163_RS12085	COG1217	gtp-binding protein TYPA
EH163_RS12095	COG0483	inositol monophosphate 1-phosphatase activity
EH163_RS12100	COG4493	Belongs to the UPF0637 family
EH163_RS12105	COG1914	H( )-stimulated, divalent metal cation uptake system
EH163_RS12130	COG1176	ABC-type spermidine putrescine transport system, permease component I
EH163_RS12135	COG3842	ATPase activity
EH163_RS12145	COG4476	Belongs to the UPF0223 family
EH163_RS12155	COG0508	dehydrogenase complex catalyzes the overall conversion of
EH163_RS12160	COG0022	dehydrogenase e1 component
EH163_RS12165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EH163_RS12175	COG0242	peptide deformylase activity
EH163_RS12180	COG5503	Protein of unknown function (DUF1447)
EH163_RS12185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EH163_RS12190	COG0569	domain protein
EH163_RS12195	COG1294	oxidase, subunit
EH163_RS12200	COG1271	oxidase subunit
EH163_RS12210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EH163_RS12215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EH163_RS12225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EH163_RS12240	COG4716	Myosin-crossreactive antigen
EH163_RS12250	COG4172	Belongs to the ABC transporter superfamily
EH163_RS12255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EH163_RS12260	COG0151	Belongs to the GarS family
EH163_RS12265	COG0138	bifunctional purine biosynthesis protein purh
EH163_RS12270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EH163_RS12275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EH163_RS12280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EH163_RS12285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EH163_RS12290	COG0047	phosphoribosylformylglycinamidine synthase activity
EH163_RS12295	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EH163_RS12300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EH163_RS12305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EH163_RS12310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EH163_RS12315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EH163_RS12325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EH163_RS12330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EH163_RS12335	COG1845	cytochrome c oxidase, subunit III
EH163_RS12340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EH163_RS12360	COG1316	TRANSCRIPTIONal
EH163_RS12385	COG3594	Acyltransferase
EH163_RS12390	COG0436	Aminotransferase
EH163_RS12395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EH163_RS12405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EH163_RS12410	COG1169	isochorismate synthase
EH163_RS12420	COG1575	Belongs to the MenA family. Type 1 subfamily
EH163_RS12430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EH163_RS12440	COG2314	TM2 domain
EH163_RS12490	COG1388	LysM domain
EH163_RS12490	COG5632	N-Acetylmuramoyl-L-alanine amidase
EH163_RS12515	COG4195	phage-related replication protein
EH163_RS12600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EH163_RS12635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EH163_RS12700	COG1136	(ABC) transporter
EH163_RS12700	COG0577	efflux transmembrane transporter activity
EH163_RS12780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process