locus-tag	class	description
DQW72_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DQW72_RS00010	COG0592	DNA-directed DNA polymerase activity
DQW72_RS00015	COG2501	S4 domain
DQW72_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DQW72_RS00025	COG0187	DNA topoisomerase II activity
DQW72_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DQW72_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DQW72_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DQW72_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DQW72_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DQW72_RS00075	COG0359	binds to the 23S rRNA
DQW72_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
DQW72_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DQW72_RS00105	COG0745	RESPONSE REGULATOR receiver
DQW72_RS00110	COG5002	protein histidine kinase activity
DQW72_RS00115	COG4863	YycH protein
DQW72_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DQW72_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DQW72_RS00135	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DQW72_RS00140	COG3421	Type III restriction
DQW72_RS00145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DQW72_RS00195	COG0745	RESPONSE REGULATOR receiver
DQW72_RS00200	COG2205	protein histidine kinase activity
DQW72_RS00210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DQW72_RS00215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DQW72_RS00235	COG2801	Transposase and inactivated derivatives
DQW72_RS00245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DQW72_RS00250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DQW72_RS00260	COG2235	arginine
DQW72_RS00295	COG0076	glutamate decarboxylase activity
DQW72_RS00320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DQW72_RS00330	COG1131	(ABC) transporter
DQW72_RS00345	COG0745	RESPONSE REGULATOR receiver
DQW72_RS00350	COG5002	protein histidine kinase activity
DQW72_RS00375	COG2217	Heavy metal translocating P-type atpase
DQW72_RS00380	COG1388	LysM domain
DQW72_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DQW72_RS00390	COG2210	Belongs to the sulfur carrier protein TusA family
DQW72_RS00395	COG1937	Protein conserved in bacteria
DQW72_RS00400	COG0730	response to heat
DQW72_RS00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DQW72_RS00410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DQW72_RS00430	COG0640	Transcriptional regulator
DQW72_RS00435	COG0701	Predicted permease
DQW72_RS00450	COG0668	transmembrane transport
DQW72_RS00455	COG0561	phosphatase activity
DQW72_RS00495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DQW72_RS00500	COG0579	oxidoreductase
DQW72_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS00525	COG1755	Isoprenylcysteine carboxyl methyltransferase
DQW72_RS00535	COG2207	Transcriptional regulator
DQW72_RS00535	COG4753	response regulator
DQW72_RS00540	COG2972	Histidine kinase
DQW72_RS00605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DQW72_RS00610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DQW72_RS00615	COG0156	8-amino-7-oxononanoate synthase activity
DQW72_RS00620	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DQW72_RS00650	COG0523	cobalamin synthesis protein
DQW72_RS00675	COG0431	NADPH-dependent FMN reductase
DQW72_RS00675	COG1053	succinate dehydrogenase
DQW72_RS00675	COG3976	FMN-binding domain protein
DQW72_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS00725	COG0601	transmembrane transport
DQW72_RS00735	COG0444	Belongs to the ABC transporter superfamily
DQW72_RS00740	COG1124	(ABC) transporter
DQW72_RS00750	COG1882	Formate acetyltransferase
DQW72_RS00755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DQW72_RS00760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DQW72_RS00765	COG1114	Component of the transport system for branched-chain amino acids
DQW72_RS00770	COG1309	transcriptional regulator
DQW72_RS00775	COG3246	L-lysine catabolic process to acetate
DQW72_RS00780	COG1250	3-hydroxyacyl-CoA dehydrogenase
DQW72_RS00815	COG1288	antiporter activity
DQW72_RS00820	COG0549	Belongs to the carbamate kinase family
DQW72_RS00825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DQW72_RS00835	COG0346	lactoylglutathione lyase activity
DQW72_RS00840	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DQW72_RS00845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DQW72_RS00855	COG2376	Dihydroxyacetone kinase
DQW72_RS00860	COG1461	Dihydroxyacetone kinase
DQW72_RS00865	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DQW72_RS00875	COG2814	Major facilitator Superfamily
DQW72_RS00880	COG0583	DNA-binding transcription factor activity
DQW72_RS00890	COG2814	Major facilitator Superfamily
DQW72_RS00925	COG2814	Major facilitator Superfamily
DQW72_RS00940	COG2962	Rard protein
DQW72_RS00945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DQW72_RS00950	COG0471	metal ion transport
DQW72_RS00955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DQW72_RS00960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DQW72_RS00965	COG0022	dehydrogenase e1 component
DQW72_RS00970	COG0508	dehydrogenase complex catalyzes the overall conversion of
DQW72_RS00990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DQW72_RS00995	COG1054	Belongs to the UPF0176 family
DQW72_RS01000	COG3386	PFAM SMP-30 Gluconolaconase
DQW72_RS01005	COG2353	YceI-like domain
DQW72_RS01015	COG0579	oxidoreductase
DQW72_RS01040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DQW72_RS01045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DQW72_RS01050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DQW72_RS01055	COG0131	Imidazoleglycerol-phosphate dehydratase
DQW72_RS01060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DQW72_RS01065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DQW72_RS01070	COG0107	imidazoleglycerol-phosphate synthase activity
DQW72_RS01075	COG0140	phosphoribosyl-ATP diphosphatase activity
DQW72_RS01075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DQW72_RS01080	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DQW72_RS01090	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DQW72_RS01100	COG0726	polysaccharide deacetylase
DQW72_RS01110	COG1215	transferase activity, transferring glycosyl groups
DQW72_RS01115	COG1309	transcriptional regulator
DQW72_RS01130	COG2814	Major facilitator Superfamily
DQW72_RS01135	COG0737	Belongs to the 5'-nucleotidase family
DQW72_RS01150	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DQW72_RS01155	COG3639	organic phosphonate transmembrane transporter activity
DQW72_RS01175	COG0201	protein transport
DQW72_RS01185	COG1073	alpha beta
DQW72_RS01195	COG0653	protein targeting
DQW72_RS01200	COG0438	transferase activity, transferring glycosyl groups
DQW72_RS01225	COG2814	Major facilitator Superfamily
DQW72_RS01230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DQW72_RS01245	COG1764	response to oxidative stress
DQW72_RS01255	COG3942	CHAP domain
DQW72_RS01255	COG1705	Flagellar rod assembly protein muramidase FlgJ
DQW72_RS01265	COG1482	cell wall glycoprotein biosynthetic process
DQW72_RS01270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DQW72_RS01270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DQW72_RS01270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DQW72_RS01275	COG3711	transcriptional antiterminator
DQW72_RS01275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DQW72_RS01305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DQW72_RS01310	COG3227	Zinc metalloprotease (Elastase)
DQW72_RS01315	COG1438	arginine binding
DQW72_RS01320	COG2235	arginine
DQW72_RS01325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DQW72_RS01335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DQW72_RS01345	COG2843	Capsule synthesis protein
DQW72_RS01355	COG3961	Belongs to the TPP enzyme family
DQW72_RS01395	COG0583	DNA-binding transcription factor activity
DQW72_RS01420	COG0640	Transcriptional regulator
DQW72_RS01455	COG1397	ADP-ribosylglycohydrolase
DQW72_RS01490	COG4195	phage-related replication protein
DQW72_RS01500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DQW72_RS01505	COG0702	epimerase
DQW72_RS01510	COG1785	Belongs to the alkaline phosphatase family
DQW72_RS01525	COG2205	protein histidine kinase activity
DQW72_RS01530	COG1136	(ABC) transporter
DQW72_RS01545	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DQW72_RS01570	COG1846	Transcriptional regulator
DQW72_RS01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DQW72_RS01580	COG0386	Belongs to the glutathione peroxidase family
DQW72_RS01590	COG0175	sulfate reduction
DQW72_RS01595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DQW72_RS01600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DQW72_RS01615	COG0730	response to heat
DQW72_RS01620	COG2046	Belongs to the sulfate adenylyltransferase family
DQW72_RS01625	COG0529	Catalyzes the synthesis of activated sulfate
DQW72_RS01635	COG1328	CTP reductase activity
DQW72_RS01640	COG0602	queuosine metabolic process
DQW72_RS01645	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DQW72_RS01665	COG1510	regulation of RNA biosynthetic process
DQW72_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS01675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DQW72_RS01680	COG1473	amidohydrolase
DQW72_RS01695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DQW72_RS01700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DQW72_RS01700	COG0574	Belongs to the PEP-utilizing enzyme family
DQW72_RS01705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DQW72_RS01710	COG0579	oxidoreductase
DQW72_RS01720	COG3588	fructose-bisphosphate aldolase
DQW72_RS01730	COG0446	pyridine nucleotide-disulphide oxidoreductase
DQW72_RS01765	COG0531	amino acid
DQW72_RS01770	COG0583	DNA-binding transcription factor activity
DQW72_RS01775	COG0039	L-malate dehydrogenase activity
DQW72_RS01780	COG0028	Belongs to the TPP enzyme family
DQW72_RS01785	COG3527	Alpha-acetolactate decarboxylase
DQW72_RS01795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DQW72_RS01800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DQW72_RS01805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DQW72_RS01820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DQW72_RS01830	COG0167	dihydroorotate dehydrogenase activity
DQW72_RS01835	COG3001	Fructosamine kinase
DQW72_RS01840	COG1113	amino acid transport
DQW72_RS01860	COG0741	lytic transglycosylase activity
DQW72_RS01870	COG3942	CHAP domain
DQW72_RS01880	COG0436	Aminotransferase
DQW72_RS01890	COG2608	mercury ion transmembrane transporter activity
DQW72_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS01935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DQW72_RS01940	COG3425	synthase
DQW72_RS01960	COG0583	DNA-binding transcription factor activity
DQW72_RS01965	COG1380	Effector of murein hydrolase LrgA
DQW72_RS01970	COG1346	cytolysis
DQW72_RS01975	COG0028	Belongs to the TPP enzyme family
DQW72_RS01980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DQW72_RS01980	COG2190	(PTS) system
DQW72_RS01980	COG1263	PTS System
DQW72_RS02000	COG1063	alcohol dehydrogenase
DQW72_RS02010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DQW72_RS02025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DQW72_RS02035	COG2843	Capsule synthesis protein
DQW72_RS02050	COG4975	Glucose uptake
DQW72_RS02055	COG1869	D-ribose catabolic process
DQW72_RS02065	COG1070	Carbohydrate kinase
DQW72_RS02085	COG1760	l-serine dehydratase
DQW72_RS02090	COG1760	l-serine dehydratase
DQW72_RS02105	COG3764	Sortase (surface protein transpeptidase)
DQW72_RS02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DQW72_RS02120	COG0778	Nitroreductase
DQW72_RS02130	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS02140	COG2514	catechol 2,3-dioxygenase activity
DQW72_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS02160	COG3949	Membrane
DQW72_RS02175	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DQW72_RS02180	COG0586	Pfam SNARE associated Golgi protein
DQW72_RS02185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DQW72_RS02190	COG2022	thiamine diphosphate biosynthetic process
DQW72_RS02200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DQW72_RS02210	COG2271	Major facilitator Superfamily
DQW72_RS02225	COG4876	unkown
DQW72_RS02250	COG0789	Transcriptional regulator
DQW72_RS02255	COG2271	Major facilitator Superfamily
DQW72_RS02260	COG1802	Transcriptional regulator
DQW72_RS02270	COG2610	gluconate transmembrane transporter activity
DQW72_RS02275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DQW72_RS02280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DQW72_RS02285	COG0438	transferase activity, transferring glycosyl groups
DQW72_RS02290	COG0494	nUDIX hydrolase
DQW72_RS02295	COG0556	nucleotide-excision repair
DQW72_RS02310	COG4221	oxidoreductase activity
DQW72_RS02315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DQW72_RS02320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DQW72_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS02340	COG1363	Peptidase, m42
DQW72_RS02350	COG0069	glutamate synthase activity
DQW72_RS02370	COG4619	ABC transporter
DQW72_RS02375	COG0390	transport system, permease component
DQW72_RS02380	COG2814	Major facilitator Superfamily
DQW72_RS02385	COG2272	Belongs to the type-B carboxylesterase lipase family
DQW72_RS02390	COG0531	amino acid
DQW72_RS02400	COG1063	alcohol dehydrogenase
DQW72_RS02420	COG1174	glycine betaine transport
DQW72_RS02425	COG1346	cytolysis
DQW72_RS02430	COG1380	Effector of murein hydrolase LrgA
DQW72_RS02435	COG3279	Response regulator of the LytR AlgR family
DQW72_RS02440	COG3275	phosphorelay sensor kinase activity
DQW72_RS02450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DQW72_RS02455	COG0706	membrane insertase activity
DQW72_RS02465	COG0531	amino acid
DQW72_RS02470	COG1113	amino acid transport
DQW72_RS02495	COG1929	Belongs to the glycerate kinase type-1 family
DQW72_RS02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DQW72_RS02515	COG0588	phosphoglycerate mutase activity
DQW72_RS02525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DQW72_RS02530	COG0765	amino acid transport
DQW72_RS02535	COG1126	abc transporter atp-binding protein
DQW72_RS02540	COG2348	transferase activity, transferring amino-acyl groups
DQW72_RS02560	COG2116	formate transmembrane transporter activity
DQW72_RS02565	COG0454	-acetyltransferase
DQW72_RS02570	COG0747	negative chemotaxis
DQW72_RS02585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DQW72_RS02590	COG2146	nitrite reductase [NAD(P)H] activity
DQW72_RS02600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DQW72_RS02605	COG1140	nitrate reductase beta subunit
DQW72_RS02615	COG2181	nitrate reductase activity
DQW72_RS02625	COG4585	Histidine kinase
DQW72_RS02630	COG2197	response regulator
DQW72_RS02635	COG2223	nitrite transmembrane transporter activity
DQW72_RS02640	COG1846	Transcriptional regulator
DQW72_RS02645	COG0778	Nitroreductase
DQW72_RS02665	COG3871	stress protein (general stress protein 26)
DQW72_RS02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DQW72_RS02680	COG1263	PTS System
DQW72_RS02715	COG0604	alcohol dehydrogenase
DQW72_RS02720	COG0456	acetyltransferase
DQW72_RS02725	COG0463	Glycosyl transferase, family 2
DQW72_RS02725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DQW72_RS02735	COG0463	Glycosyl transferase, family 2
DQW72_RS02735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DQW72_RS02740	COG1620	l-lactate permease
DQW72_RS02745	COG0438	transferase activity, transferring glycosyl groups
DQW72_RS02750	COG0579	oxidoreductase
DQW72_RS02755	COG5002	protein histidine kinase activity
DQW72_RS02755	COG3850	Histidine kinase
DQW72_RS02760	COG0745	RESPONSE REGULATOR receiver
DQW72_RS02765	COG0577	efflux transmembrane transporter activity
DQW72_RS02770	COG1136	(ABC) transporter
DQW72_RS02785	COG4640	response to antibiotic
DQW72_RS02790	COG2814	Major facilitator Superfamily
DQW72_RS02800	COG1566	PFAM secretion protein HlyD family protein
DQW72_RS02805	COG2814	Major facilitator Superfamily
DQW72_RS02820	COG0657	acetylesterase activity
DQW72_RS02835	COG0598	Magnesium transport protein CorA
DQW72_RS02840	COG1304	FMN binding
DQW72_RS02845	COG0786	glutamate:sodium symporter activity
DQW72_RS02865	COG2094	Belongs to the DNA glycosylase MPG family
DQW72_RS02880	COG1069	ribulokinase activity
DQW72_RS02885	COG2017	converts alpha-aldose to the beta-anomer
DQW72_RS02890	COG2258	MOSC domain
DQW72_RS02895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DQW72_RS02910	COG1266	CAAX protease self-immunity
DQW72_RS02915	COG0010	Belongs to the arginase family
DQW72_RS02920	COG1473	amidohydrolase
DQW72_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DQW72_RS02955	COG1737	Transcriptional regulator
DQW72_RS02960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DQW72_RS02960	COG1263	PTS System
DQW72_RS02970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DQW72_RS02990	COG1113	amino acid transport
DQW72_RS03000	COG1263	PTS System
DQW72_RS03000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DQW72_RS03005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DQW72_RS03020	COG1266	CAAX protease self-immunity
DQW72_RS03025	COG2378	regulation of single-species biofilm formation
DQW72_RS03030	COG0483	inositol monophosphate 1-phosphatase activity
DQW72_RS03035	COG1316	TRANSCRIPTIONal
DQW72_RS03060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DQW72_RS03065	COG2076	Multidrug Resistance protein
DQW72_RS03070	COG2076	Multidrug Resistance protein
DQW72_RS03075	COG3942	CHAP domain
DQW72_RS03090	COG1757	Na H antiporter
DQW72_RS03095	COG3942	CHAP domain
DQW72_RS03120	COG0829	nickel cation binding
DQW72_RS03125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DQW72_RS03130	COG0830	nickel cation binding
DQW72_RS03135	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DQW72_RS03140	COG0804	urea catabolic process
DQW72_RS03145	COG0832	Belongs to the urease beta subunit family
DQW72_RS03150	COG0831	urea catabolic process
DQW72_RS03165	COG1960	acyl-CoA dehydrogenase activity
DQW72_RS03170	COG1957	nucleoside hydrolase
DQW72_RS03175	COG1268	BioY protein
DQW72_RS03190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DQW72_RS03200	COG0725	ABC transporter, periplasmic molybdate-binding protein
DQW72_RS03205	COG4149	molybdate abc transporter
DQW72_RS03210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DQW72_RS03215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DQW72_RS03220	COG0521	Mo-molybdopterin cofactor biosynthetic process
DQW72_RS03225	COG0315	cyclic pyranopterin monophosphate synthase activity
DQW72_RS03230	COG0303	'Molybdopterin
DQW72_RS03240	COG0314	molybdopterin synthase activity
DQW72_RS03250	COG0746	molybdenum cofactor guanylyltransferase activity
DQW72_RS03255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DQW72_RS03280	COG2814	Major facilitator Superfamily
DQW72_RS03295	COG2348	transferase activity, transferring amino-acyl groups
DQW72_RS03300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DQW72_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS03325	COG4975	Glucose uptake
DQW72_RS03330	COG0551	DNA topoisomerase type I activity
DQW72_RS03330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DQW72_RS03335	COG2252	PERMEase
DQW72_RS03350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DQW72_RS03355	COG0088	Forms part of the polypeptide exit tunnel
DQW72_RS03360	COG0089	rRNA binding
DQW72_RS03365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DQW72_RS03370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DQW72_RS03375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DQW72_RS03380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DQW72_RS03385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DQW72_RS03395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DQW72_RS03400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DQW72_RS03405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DQW72_RS03410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DQW72_RS03415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DQW72_RS03420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DQW72_RS03425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DQW72_RS03430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DQW72_RS03435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DQW72_RS03440	COG1841	ribosomal large subunit assembly
DQW72_RS03445	COG0200	Binds to the 23S rRNA
DQW72_RS03450	COG0201	protein transport
DQW72_RS03455	COG0563	adenylate kinase activity
DQW72_RS03460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DQW72_RS03465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DQW72_RS03470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DQW72_RS03475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DQW72_RS03480	COG0202	RNA polymerase activity
DQW72_RS03485	COG0203	ribosomal protein L17
DQW72_RS03490	COG1122	ATPase activity
DQW72_RS03495	COG1122	ATPase activity
DQW72_RS03505	COG0101	tRNA pseudouridine synthase activity
DQW72_RS03510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DQW72_RS03515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DQW72_RS03520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DQW72_RS03525	COG1349	DNA-binding transcription factor activity
DQW72_RS03530	COG0698	ribose 5-phosphate isomerase
DQW72_RS03535	COG0698	ribose 5-phosphate isomerase
DQW72_RS03540	COG1105	Belongs to the carbohydrate kinase PfkB family
DQW72_RS03545	COG3684	Belongs to the aldolase LacD family
DQW72_RS03550	COG1447	Phosphotransferase system cellobiose-specific component IIA
DQW72_RS03555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DQW72_RS03555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DQW72_RS03560	COG2723	6-phospho-beta-galactosidase activity
DQW72_RS03570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DQW72_RS03575	COG2130	NADP-dependent
DQW72_RS03580	COG0604	alcohol dehydrogenase
DQW72_RS03595	COG1302	Protein conserved in bacteria
DQW72_RS03600	COG4264	IucA IucC family
DQW72_RS03605	COG2814	Major facilitator Superfamily
DQW72_RS03610	COG4264	IucA IucC family
DQW72_RS03615	COG3457	Alanine racemase
DQW72_RS03620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DQW72_RS03625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DQW72_RS03630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DQW72_RS03635	COG3314	Sporulation integral membrane protein YlbJ
DQW72_RS03640	COG2329	Antibiotic biosynthesis monooxygenase
DQW72_RS03650	COG1988	membrane-bound metal-dependent
DQW72_RS03655	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DQW72_RS03675	COG2814	Major facilitator Superfamily
DQW72_RS03680	COG0489	protein tyrosine kinase activity
DQW72_RS03730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DQW72_RS03740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DQW72_RS03745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DQW72_RS03750	COG0561	phosphatase activity
DQW72_RS03770	COG0640	Transcriptional regulator
DQW72_RS03775	COG0702	epimerase
DQW72_RS03785	COG1482	cell wall glycoprotein biosynthetic process
DQW72_RS03810	COG0783	Belongs to the Dps family
DQW72_RS03815	COG0813	purine-nucleoside phosphorylase activity
DQW72_RS03820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DQW72_RS03825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DQW72_RS03830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DQW72_RS03840	COG1854	S-ribosylhomocysteine lyase activity
DQW72_RS03860	COG5146	pantothenate kinase activity
DQW72_RS03870	COG3343	RNA polymerase activity
DQW72_RS03875	COG0504	CTP synthase activity
DQW72_RS03885	COG0191	fructose-bisphosphate aldolase activity
DQW72_RS03890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DQW72_RS03895	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS03900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DQW72_RS03905	COG0254	rRNA binding
DQW72_RS03915	COG1435	thymidine kinase activity
DQW72_RS03920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DQW72_RS03925	COG2890	protein-(glutamine-N5) methyltransferase activity
DQW72_RS03935	COG0009	L-threonylcarbamoyladenylate synthase
DQW72_RS03940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DQW72_RS03945	COG4475	Protein of unknown function (DUF436)
DQW72_RS03950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DQW72_RS03955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DQW72_RS03960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DQW72_RS03970	COG0356	it plays a direct role in the translocation of protons across the membrane
DQW72_RS03980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DQW72_RS03985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DQW72_RS03990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DQW72_RS03995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DQW72_RS04000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DQW72_RS04005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DQW72_RS04015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DQW72_RS04020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DQW72_RS04030	COG0629	single-stranded DNA binding
DQW72_RS04035	COG1388	LysM domain
DQW72_RS04040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DQW72_RS04050	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DQW72_RS04055	COG0352	thiamine-phosphate diphosphorylase activity
DQW72_RS04060	COG0706	membrane insertase activity
DQW72_RS04065	COG1418	mRNA catabolic process
DQW72_RS04070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DQW72_RS04075	COG1937	Protein conserved in bacteria
DQW72_RS04090	COG0772	Belongs to the SEDS family
DQW72_RS04095	COG1181	Belongs to the D-alanine--D-alanine ligase family
DQW72_RS04100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DQW72_RS04105	COG0513	Belongs to the DEAD box helicase family
DQW72_RS04115	COG3428	Bacterial PH domain
DQW72_RS04120	COG3402	PFAM membrane-flanked domain
DQW72_RS04125	COG0736	holo-[acyl-carrier-protein] synthase activity
DQW72_RS04130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DQW72_RS04140	COG2337	Toxic component of a toxin-antitoxin (TA) module
DQW72_RS04145	COG2208	phosphoserine phosphatase activity
DQW72_RS04160	COG1191	sigma factor activity
DQW72_RS04165	COG2183	response to ionizing radiation
DQW72_RS04170	COG3091	SprT-like family
DQW72_RS04210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DQW72_RS04215	COG0066	3-isopropylmalate dehydratase activity
DQW72_RS04220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DQW72_RS04225	COG0473	3-isopropylmalate dehydrogenase activity
DQW72_RS04230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DQW72_RS04235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DQW72_RS04245	COG0028	Belongs to the TPP enzyme family
DQW72_RS04250	COG0129	dihydroxy-acid dehydratase activity
DQW72_RS04255	COG0802	atpase or kinase
DQW72_RS04260	COG1214	PFAM Peptidase M22, glycoprotease
DQW72_RS04265	COG0456	acetyltransferase
DQW72_RS04270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DQW72_RS04275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DQW72_RS04280	COG0488	(ABC) transporter
DQW72_RS04285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DQW72_RS04295	COG2391	methyltransferase activity
DQW72_RS04300	COG0425	Belongs to the sulfur carrier protein TusA family
DQW72_RS04305	COG0004	ammonium transporteR
DQW72_RS04310	COG1609	Transcriptional regulator
DQW72_RS04320	COG1621	beta-fructofuranosidase activity
DQW72_RS04325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DQW72_RS04330	COG3279	Response regulator of the LytR AlgR family
DQW72_RS04335	COG3290	protein histidine kinase activity
DQW72_RS04370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DQW72_RS04375	COG0459	protein refolding
DQW72_RS04395	COG1725	Transcriptional regulator
DQW72_RS04400	COG1131	(ABC) transporter
DQW72_RS04410	COG1131	(ABC) transporter
DQW72_RS04455	COG2706	6-phosphogluconolactonase activity
DQW72_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS04465	COG1227	inorganic diphosphatase activity
DQW72_RS04470	COG1335	isochorismatase
DQW72_RS04480	COG0077	Prephenate dehydratase
DQW72_RS04490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DQW72_RS04495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DQW72_RS04500	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DQW72_RS04510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DQW72_RS04515	COG4496	protein, YerC YecD
DQW72_RS04520	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DQW72_RS04525	COG0210	DNA helicase
DQW72_RS04530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DQW72_RS04535	COG4851	CamS sex pheromone cAM373 precursor
DQW72_RS04540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DQW72_RS04545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DQW72_RS04550	COG0154	amidase activity
DQW72_RS04555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DQW72_RS04560	COG1597	lipid kinase activity
DQW72_RS04565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DQW72_RS04575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DQW72_RS04585	COG1528	Iron-storage protein
DQW72_RS04605	COG4129	membrane
DQW72_RS04610	COG0024	Methionine aminopeptidase
DQW72_RS04625	COG4585	Histidine kinase
DQW72_RS04630	COG2197	response regulator
DQW72_RS04635	COG1295	ribonuclease BN
DQW72_RS04645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DQW72_RS04650	COG4840	Belongs to the UPF0435 family
DQW72_RS04655	COG2309	aminopeptidase activity
DQW72_RS04660	COG1607	acyl-coa hydrolase
DQW72_RS04665	COG0535	radical SAM domain protein
DQW72_RS04675	COG0693	protein deglycase activity
DQW72_RS04680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DQW72_RS04685	COG2137	regulation of response to DNA damage stimulus
DQW72_RS04695	COG1134	teichoic acid transport
DQW72_RS04695	COG1388	LysM domain
DQW72_RS04705	COG1988	membrane-bound metal-dependent
DQW72_RS04715	COG3557	Belongs to the UPF0374 family
DQW72_RS04725	COG4129	membrane
DQW72_RS04730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DQW72_RS04735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DQW72_RS04740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DQW72_RS04745	COG0735	belongs to the Fur family
DQW72_RS04905	COG0765	amino acid transport
DQW72_RS04910	COG1126	abc transporter atp-binding protein
DQW72_RS04915	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DQW72_RS04940	COG0114	fumarate hydratase activity
DQW72_RS04945	COG0564	pseudouridine synthase activity
DQW72_RS04950	COG2203	Gaf domain
DQW72_RS04950	COG4585	Histidine kinase
DQW72_RS04955	COG2197	response regulator
DQW72_RS04965	COG4399	Belongs to the UPF0754 family
DQW72_RS04970	COG3679	Belongs to the UPF0342 family
DQW72_RS04975	COG0420	3'-5' exonuclease activity
DQW72_RS04985	COG3481	metal-dependent phosphohydrolase, HD sub domain
DQW72_RS04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DQW72_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
DQW72_RS05015	COG1131	(ABC) transporter
DQW72_RS05020	COG4473	ABC transporter
DQW72_RS05030	COG2329	Antibiotic biosynthesis monooxygenase
DQW72_RS05035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DQW72_RS05040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DQW72_RS05045	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DQW72_RS05145	COG0318	PFAM AMP-dependent synthetase and ligase
DQW72_RS05155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DQW72_RS05160	COG0494	nUDIX hydrolase
DQW72_RS05165	COG1506	peptidase
DQW72_RS05170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DQW72_RS05175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DQW72_RS05185	COG0656	L-ascorbic acid biosynthetic process
DQW72_RS05190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DQW72_RS05195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DQW72_RS05205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DQW72_RS05235	COG4193	domain, Protein
DQW72_RS05235	COG3266	domain, Protein
DQW72_RS05235	COG5632	N-Acetylmuramoyl-L-alanine amidase
DQW72_RS05245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DQW72_RS05245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DQW72_RS05255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DQW72_RS05255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DQW72_RS05260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DQW72_RS05265	COG0506	proline dehydrogenase activity
DQW72_RS05270	COG2267	carboxylic ester hydrolase activity
DQW72_RS05280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DQW72_RS05285	COG1242	4 iron, 4 sulfur cluster binding
DQW72_RS05290	COG2814	Major facilitator Superfamily
DQW72_RS05295	COG0495	leucyl-tRNA aminoacylation
DQW72_RS05310	COG2081	HI0933 family
DQW72_RS05315	COG2244	polysaccharide biosynthetic process
DQW72_RS05320	COG1187	pseudouridine synthase activity
DQW72_RS05330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DQW72_RS05335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DQW72_RS05340	COG0510	thiamine kinase activity
DQW72_RS05345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DQW72_RS05355	COG1363	Peptidase, m42
DQW72_RS05360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DQW72_RS05365	COG4848	Belongs to the UPF0354 family
DQW72_RS05370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DQW72_RS05375	COG1674	ftsk spoiiie
DQW72_RS05380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DQW72_RS05385	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DQW72_RS05395	COG1605	Chorismate mutase
DQW72_RS05395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DQW72_RS05400	COG1609	Transcriptional regulator
DQW72_RS05405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DQW72_RS05415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DQW72_RS05420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DQW72_RS05425	COG0204	Acyl-transferase
DQW72_RS05430	COG1263	PTS System
DQW72_RS05430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DQW72_RS05440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DQW72_RS05445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DQW72_RS05450	COG1764	response to oxidative stress
DQW72_RS05455	COG0584	glycerophosphoryl diester phosphodiesterase
DQW72_RS05460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DQW72_RS05470	COG1956	GAF domain-containing protein
DQW72_RS05475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DQW72_RS05485	COG0301	tRNA thio-modification
DQW72_RS05495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DQW72_RS05500	COG0827	DNA restriction-modification system
DQW72_RS05505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DQW72_RS05510	COG0589	response to stress
DQW72_RS05515	COG0686	Belongs to the AlaDH PNT family
DQW72_RS05520	COG0006	proline dipeptidase activity
DQW72_RS05525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DQW72_RS05535	COG4109	DRTGG domain
DQW72_RS05540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DQW72_RS05545	COG0587	DNA-directed DNA polymerase activity
DQW72_RS05550	COG0281	malic enzyme
DQW72_RS05555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DQW72_RS05560	COG0825	malonyl-CoA metabolic process
DQW72_RS05565	COG0205	6-phosphofructokinase activity
DQW72_RS05570	COG0469	pyruvate kinase activity
DQW72_RS05575	COG1113	amino acid transport
DQW72_RS05580	COG0372	Belongs to the citrate synthase family
DQW72_RS05585	COG0538	isocitrate dehydrogenase activity
DQW72_RS05590	COG0745	RESPONSE REGULATOR receiver
DQW72_RS05595	COG5002	protein histidine kinase activity
DQW72_RS05600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DQW72_RS05600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DQW72_RS05605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DQW72_RS05610	COG0237	dephospho-CoA kinase activity
DQW72_RS05620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DQW72_RS05630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DQW72_RS05635	COG3611	Membrane attachment protein
DQW72_RS05640	COG1484	DNA-dependent DNA replication
DQW72_RS05645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DQW72_RS05650	COG0833	amino acid
DQW72_RS05655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DQW72_RS05660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DQW72_RS05665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DQW72_RS05670	COG4112	unkown
DQW72_RS05680	COG0544	peptidyl-prolyl cis-trans isomerase activity
DQW72_RS05685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DQW72_RS05690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DQW72_RS05695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DQW72_RS05705	COG0181	hydroxymethylbilane synthase activity
DQW72_RS05715	COG0113	porphobilinogen synthase activity
DQW72_RS05720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DQW72_RS05730	COG2818	Glycosylase
DQW72_RS05735	COG0525	valine-tRNA ligase activity
DQW72_RS05740	COG0285	dihydrofolate synthase activity
DQW72_RS05750	COG2003	Belongs to the UPF0758 family
DQW72_RS05780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DQW72_RS05785	COG2868	ribosomal protein
DQW72_RS05790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DQW72_RS05795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DQW72_RS05800	COG4492	Belongs to the UPF0735 family
DQW72_RS05805	COG0632	four-way junction helicase activity
DQW72_RS05810	COG2255	four-way junction helicase activity
DQW72_RS05815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DQW72_RS05820	COG0343	queuine tRNA-ribosyltransferase activity
DQW72_RS05825	COG1862	Preprotein translocase
DQW72_RS05830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DQW72_RS05830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DQW72_RS05835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DQW72_RS05835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DQW72_RS05840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DQW72_RS05850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DQW72_RS05855	COG1490	D-aminoacyl-tRNA deacylase activity
DQW72_RS05860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DQW72_RS05865	COG0124	histidyl-tRNA synthetase
DQW72_RS05870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DQW72_RS05880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DQW72_RS05885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DQW72_RS05890	COG1959	2 iron, 2 sulfur cluster binding
DQW72_RS05900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DQW72_RS05905	COG1104	cysteine desulfurase activity
DQW72_RS05910	COG0482	sulfurtransferase activity
DQW72_RS05920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DQW72_RS05925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DQW72_RS05930	COG4472	Bacterial protein of unknown function (DUF965)
DQW72_RS05935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DQW72_RS05940	COG3906	Belongs to the UPF0473 family
DQW72_RS05950	COG0826	peptidase U32
DQW72_RS05955	COG0826	peptidase U32
DQW72_RS05960	COG0572	uridine kinase
DQW72_RS05965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DQW72_RS05975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DQW72_RS05980	COG1984	allophanate hydrolase subunit 2
DQW72_RS05985	COG0511	ligase activity, forming carbon-carbon bonds
DQW72_RS05990	COG0439	Biotin carboxylase
DQW72_RS05995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DQW72_RS06000	COG1914	H( )-stimulated, divalent metal cation uptake system
DQW72_RS06005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DQW72_RS06010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DQW72_RS06015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DQW72_RS06020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DQW72_RS06025	COG1534	Rna-binding protein
DQW72_RS06030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DQW72_RS06035	COG1713	HD superfamily hydrolase involved in NAD metabolism
DQW72_RS06040	COG0799	negative regulation of ribosome biogenesis
DQW72_RS06045	COG2226	methyltransferase
DQW72_RS06055	COG2131	deaminase
DQW72_RS06060	COG0658	competence protein
DQW72_RS06060	COG2333	competence protein COMEC
DQW72_RS06065	COG1466	dna polymerase III delta subunit
DQW72_RS06070	COG0268	Binds directly to 16S ribosomal RNA
DQW72_RS06075	COG0481	GTPase activity
DQW72_RS06080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DQW72_RS06085	COG1420	regulation of RNA biosynthetic process
DQW72_RS06090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DQW72_RS06095	COG0443	Heat shock 70 kDa protein
DQW72_RS06100	COG0484	heat shock protein binding
DQW72_RS06105	COG2264	protein methyltransferase activity
DQW72_RS06110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DQW72_RS06115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DQW72_RS06125	COG1030	water channel activity
DQW72_RS06130	COG4864	UPF0365 protein
DQW72_RS06140	COG1702	phosphate starvation-inducible protein PhoH
DQW72_RS06145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DQW72_RS06150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DQW72_RS06155	COG0295	cytidine deaminase activity
DQW72_RS06160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DQW72_RS06165	COG1381	Involved in DNA repair and RecF pathway recombination
DQW72_RS06170	COG0423	glycine-tRNA ligase activity
DQW72_RS06175	COG0517	IMP dehydrogenase activity
DQW72_RS06180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DQW72_RS06185	COG0358	DNA primase activity
DQW72_RS06190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DQW72_RS06195	COG2384	SAM-dependent methyltransferase
DQW72_RS06200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DQW72_RS06205	COG0513	Belongs to the DEAD box helicase family
DQW72_RS06210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DQW72_RS06215	COG1121	(ABC) transporter
DQW72_RS06220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DQW72_RS06225	COG0735	belongs to the Fur family
DQW72_RS06230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DQW72_RS06240	COG0768	penicillin binding
DQW72_RS06245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DQW72_RS06250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DQW72_RS06260	COG4483	Protein conserved in bacteria
DQW72_RS06265	COG1940	carbohydrate kinase activity
DQW72_RS06270	COG0011	TIGRFAM Protein of
DQW72_RS06280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DQW72_RS06285	COG1459	type II secretion system
DQW72_RS06290	COG4537	Required for transformation and DNA binding
DQW72_RS06315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DQW72_RS06320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DQW72_RS06325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DQW72_RS06330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DQW72_RS06340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DQW72_RS06345	COG0095	Lipoate-protein ligase
DQW72_RS06360	COG0006	proline dipeptidase activity
DQW72_RS06365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DQW72_RS06370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DQW72_RS06375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DQW72_RS06380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DQW72_RS06385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DQW72_RS06390	COG0511	ligase activity, forming carbon-carbon bonds
DQW72_RS06395	COG0439	Biotin carboxylase
DQW72_RS06400	COG1302	Protein conserved in bacteria
DQW72_RS06405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DQW72_RS06410	COG1570	exodeoxyribonuclease VII activity
DQW72_RS06415	COG1722	exodeoxyribonuclease VII activity
DQW72_RS06425	COG1438	arginine binding
DQW72_RS06430	COG0497	DNA recombination
DQW72_RS06435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DQW72_RS06440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DQW72_RS06445	COG0022	dehydrogenase e1 component
DQW72_RS06450	COG0508	dehydrogenase complex catalyzes the overall conversion of
DQW72_RS06460	COG4129	membrane
DQW72_RS06465	COG2195	Cleaves the N-terminal amino acid of tripeptides
DQW72_RS06470	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DQW72_RS06475	COG0366	Alpha amylase catalytic
DQW72_RS06490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DQW72_RS06495	COG1234	tRNA 3'-trailer cleavage
DQW72_RS06500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DQW72_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS06510	COG0667	Aldo Keto reductase
DQW72_RS06515	COG0494	nUDIX hydrolase
DQW72_RS06520	COG0735	belongs to the Fur family
DQW72_RS06525	COG4974	Belongs to the 'phage' integrase family
DQW72_RS06535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DQW72_RS06540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DQW72_RS06545	COG1187	pseudouridine synthase activity
DQW72_RS06550	COG0745	RESPONSE REGULATOR receiver
DQW72_RS06570	COG1141	Ferredoxin
DQW72_RS06580	COG0514	ATP-dependent DNA helicase (RecQ)
DQW72_RS06585	COG1388	LysM domain
DQW72_RS06590	COG0492	ferredoxin-NADP+ reductase activity
DQW72_RS06595	COG0252	asparaginase activity
DQW72_RS06600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DQW72_RS06605	COG0539	negative regulation of cytoplasmic translation
DQW72_RS06610	COG1160	GTP binding
DQW72_RS06615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DQW72_RS06630	COG2226	methyltransferase
DQW72_RS06640	COG0105	UTP biosynthetic process
DQW72_RS06645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DQW72_RS06650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DQW72_RS06655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DQW72_RS06665	COG5582	Belongs to the UPF0302 family
DQW72_RS06670	COG4347	Protein of unknown function (DUF1405)
DQW72_RS06675	COG2738	Putative neutral zinc metallopeptidase
DQW72_RS06680	COG1694	Mazg nucleotide pyrophosphohydrolase
DQW72_RS06685	COG0438	transferase activity, transferring glycosyl groups
DQW72_RS06690	COG0617	tRNA 3'-terminal CCA addition
DQW72_RS06695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DQW72_RS06695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DQW72_RS06700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DQW72_RS06700	COG1199	ATP-dependent helicase activity
DQW72_RS06705	COG0017	Asparaginyl-tRNA synthetase
DQW72_RS06710	COG3935	DnaD domain protein
DQW72_RS06715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DQW72_RS06725	COG4499	WXG100 protein secretion system (Wss), protein YukC
DQW72_RS06725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DQW72_RS06730	COG3331	DNA recombination
DQW72_RS06740	COG4474	Belongs to the UPF0398 family
DQW72_RS06745	COG3599	regulation of cell shape
DQW72_RS06755	COG0116	Belongs to the methyltransferase superfamily
DQW72_RS06765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DQW72_RS06770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DQW72_RS06775	COG4372	Transposase
DQW72_RS06775	COG1511	domain protein
DQW72_RS06775	COG1196	nuclear chromosome segregation
DQW72_RS06785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DQW72_RS06795	COG1413	lyase activity
DQW72_RS06810	COG1136	(ABC) transporter
DQW72_RS06835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DQW72_RS06840	COG2190	(PTS) system
DQW72_RS06845	COG4479	Belongs to the UPF0346 family
DQW72_RS06850	COG0793	Belongs to the peptidase S41A family
DQW72_RS06865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DQW72_RS06870	COG0671	phosphoesterase, PA-phosphatase related
DQW72_RS06885	COG0745	RESPONSE REGULATOR receiver
DQW72_RS06890	COG5002	protein histidine kinase activity
DQW72_RS06900	COG0567	Dehydrogenase, E1 component
DQW72_RS06905	COG0508	dehydrogenase complex catalyzes the overall conversion of
DQW72_RS06920	COG1131	(ABC) transporter
DQW72_RS06945	COG0714	Associated with various cellular activities
DQW72_RS06950	COG4548	von Willebrand factor, type A
DQW72_RS06955	COG1114	Component of the transport system for branched-chain amino acids
DQW72_RS06960	COG3853	Toxic anion resistance protein (TelA)
DQW72_RS06970	COG1254	Belongs to the acylphosphatase family
DQW72_RS06980	COG1278	Cold shock
DQW72_RS06995	COG1131	(ABC) transporter
DQW72_RS07015	COG1473	amidohydrolase
DQW72_RS07020	COG2171	N-acyltransferase activity
DQW72_RS07025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DQW72_RS07030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DQW72_RS07035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DQW72_RS07040	COG0527	aspartate kinase activity
DQW72_RS07045	COG0488	(ABC) transporter
DQW72_RS07050	COG2996	Protein conserved in bacteria
DQW72_RS07055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DQW72_RS07060	COG0573	inorganic phosphate transmembrane transporter activity
DQW72_RS07065	COG0581	inorganic phosphate transmembrane transporter activity
DQW72_RS07070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DQW72_RS07075	COG0704	Plays a role in the regulation of phosphate uptake
DQW72_RS07115	COG2348	transferase activity, transferring amino-acyl groups
DQW72_RS07120	COG2348	transferase activity, transferring amino-acyl groups
DQW72_RS07135	COG0159	tryptophan synthase activity
DQW72_RS07140	COG0133	tryptophan synthase activity
DQW72_RS07145	COG0135	phosphoribosylanthranilate isomerase activity
DQW72_RS07150	COG0134	indole-3-glycerol-phosphate synthase activity
DQW72_RS07155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DQW72_RS07160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DQW72_RS07160	COG0512	Glutamine amidotransferase of anthranilate synthase
DQW72_RS07165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DQW72_RS07170	COG0287	Prephenate dehydrogenase
DQW72_RS07175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DQW72_RS07180	COG1942	4-Oxalocrotonate Tautomerase
DQW72_RS07200	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DQW72_RS07200	COG0392	lysyltransferase activity
DQW72_RS07205	COG0628	permease
DQW72_RS07210	COG3711	transcriptional antiterminator
DQW72_RS07215	COG1115	amino acid carrier protein
DQW72_RS07220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DQW72_RS07225	COG0187	DNA topoisomerase II activity
DQW72_RS07230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DQW72_RS07235	COG4841	protein insertion into membrane
DQW72_RS07240	COG0824	Thioesterase
DQW72_RS07245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DQW72_RS07250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DQW72_RS07255	COG1970	mechanosensitive ion channel activity
DQW72_RS07260	COG0419	ATPase involved in DNA repair
DQW72_RS07265	COG0420	3'-5' exonuclease activity
DQW72_RS07270	COG4846	Membrane protein involved in cytochrome C biogenesis
DQW72_RS07280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DQW72_RS07285	COG4224	UPF0291 protein
DQW72_RS07295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DQW72_RS07305	COG2340	Cysteine-rich secretory protein family
DQW72_RS07310	COG0516	GMP reductase activity
DQW72_RS07315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DQW72_RS07325	COG0753	catalase activity
DQW72_RS07330	COG0833	amino acid
DQW72_RS07345	COG0083	homoserine kinase activity
DQW72_RS07350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DQW72_RS07355	COG0460	homoserine dehydrogenase
DQW72_RS07360	COG0527	aspartate kinase activity
DQW72_RS07375	COG1525	nuclease
DQW72_RS07385	COG2197	response regulator
DQW72_RS07390	COG4585	Histidine kinase
DQW72_RS07400	COG1131	(ABC) transporter
DQW72_RS07405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DQW72_RS07440	COG0174	glutamine synthetase
DQW72_RS07445	COG0789	Transcriptional regulator
DQW72_RS07450	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DQW72_RS07455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DQW72_RS07460	COG0386	Belongs to the glutathione peroxidase family
DQW72_RS07465	COG1923	regulation of RNA biosynthetic process
DQW72_RS07470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DQW72_RS07480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DQW72_RS07485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DQW72_RS07490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DQW72_RS07495	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DQW72_RS07500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DQW72_RS07505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DQW72_RS07515	COG4550	Control of competence regulator ComK, YlbF/YmcA
DQW72_RS07520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DQW72_RS07530	COG4195	phage-related replication protein
DQW72_RS07535	COG1013	pyruvate-flavodoxin oxidoreductase activity
DQW72_RS07540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DQW72_RS07540	COG0674	pyruvate-flavodoxin oxidoreductase activity
DQW72_RS07545	COG1692	metallophosphoesterase
DQW72_RS07555	COG1418	mRNA catabolic process
DQW72_RS07560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DQW72_RS07570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DQW72_RS07585	COG0300	oxidoreductase activity
DQW72_RS07590	COG0612	Peptidase, M16
DQW72_RS07595	COG0612	Peptidase, M16
DQW72_RS07600	COG2188	Transcriptional regulator
DQW72_RS07605	COG1674	ftsk spoiiie
DQW72_RS07610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DQW72_RS07615	COG1185	polyribonucleotide nucleotidyltransferase activity
DQW72_RS07620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DQW72_RS07625	COG0196	riboflavin kinase activity
DQW72_RS07630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DQW72_RS07635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DQW72_RS07640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DQW72_RS07645	COG1358	cellular component organization or biogenesis
DQW72_RS07650	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DQW72_RS07655	COG0195	Participates in both transcription termination and antitermination
DQW72_RS07660	COG0779	Required for maturation of 30S ribosomal subunits
DQW72_RS07665	COG2176	DNA-directed DNA polymerase activity
DQW72_RS07670	COG0442	prolyl-tRNA aminoacylation
DQW72_RS07680	COG4589	Belongs to the CDS family
DQW72_RS07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DQW72_RS07690	COG0233	cytoplasmic translational termination
DQW72_RS07695	COG0528	UMP kinase activity
DQW72_RS07700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DQW72_RS07705	COG0052	Belongs to the universal ribosomal protein uS2 family
DQW72_RS07710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DQW72_RS07715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DQW72_RS07720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DQW72_RS07725	COG4974	Belongs to the 'phage' integrase family
DQW72_RS07730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DQW72_RS07735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DQW72_RS07740	COG0758	DNA mediated transformation
DQW72_RS07750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DQW72_RS07755	COG0045	succinate-CoA ligase (ADP-forming) activity
DQW72_RS07760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DQW72_RS07775	COG4485	Bacterial membrane protein, YfhO
DQW72_RS07785	COG0335	large ribosomal subunit rRNA binding
DQW72_RS07790	COG0336	Belongs to the RNA methyltransferase TrmD family
DQW72_RS07795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DQW72_RS07800	COG0228	four-way junction DNA binding
DQW72_RS07805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DQW72_RS07810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DQW72_RS07815	COG0552	protein localization to endoplasmic reticulum
DQW72_RS07820	COG1196	nuclear chromosome segregation
DQW72_RS07825	COG0571	ribonuclease III activity
DQW72_RS07830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DQW72_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
DQW72_RS07845	COG0416	fatty acid biosynthetic process
DQW72_RS07850	COG1349	DNA-binding transcription factor activity
DQW72_RS07855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DQW72_RS07860	COG1461	Dihydroxyacetone kinase
DQW72_RS07865	COG1302	Protein conserved in bacteria
DQW72_RS07870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DQW72_RS07880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DQW72_RS07885	COG1162	GTPase activity
DQW72_RS07895	COG0631	protein serine/threonine phosphatase activity
DQW72_RS07900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DQW72_RS07905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DQW72_RS07905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DQW72_RS07910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DQW72_RS07915	COG0242	peptide deformylase activity
DQW72_RS07925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DQW72_RS07930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DQW72_RS07935	COG1758	RNA polymerase activity
DQW72_RS07940	COG0194	GDP metabolic process
DQW72_RS07960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DQW72_RS07965	COG0284	orotidine-5'-phosphate decarboxylase activity
DQW72_RS07970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DQW72_RS07975	COG0505	Belongs to the CarA family
DQW72_RS07980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DQW72_RS07985	COG0540	Belongs to the ATCase OTCase family
DQW72_RS07990	COG2233	PERMEase
DQW72_RS07995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DQW72_RS08000	COG0564	pseudouridine synthase activity
DQW72_RS08005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DQW72_RS08010	COG1388	LysM domain
DQW72_RS08010	COG3942	CHAP domain
DQW72_RS08020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DQW72_RS08025	COG3599	regulation of cell shape
DQW72_RS08035	COG0762	integral membrane protein
DQW72_RS08040	COG1799	cell septum assembly
DQW72_RS08045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DQW72_RS08050	COG1496	oxidoreductase activity
DQW72_RS08055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DQW72_RS08060	COG0849	cell division
DQW72_RS08065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DQW72_RS08070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DQW72_RS08075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DQW72_RS08080	COG0768	penicillin binding
DQW72_RS08085	COG4839	cell division protein FtsL
DQW72_RS08090	COG0275	rRNA processing
DQW72_RS08095	COG2001	Belongs to the MraZ family
DQW72_RS08100	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DQW72_RS08105	COG0454	-acetyltransferase
DQW72_RS08110	COG1011	Hydrolase
DQW72_RS08150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DQW72_RS08155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DQW72_RS08160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DQW72_RS08165	COG1053	succinate dehydrogenase
DQW72_RS08170	COG2009	succinate dehydrogenase
DQW72_RS08180	COG0322	excinuclease ABC activity
DQW72_RS08185	COG3118	belongs to the thioredoxin family
DQW72_RS08190	COG1193	negative regulation of DNA recombination
DQW72_RS08195	COG1796	DNA polymerase
DQW72_RS08195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DQW72_RS08205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DQW72_RS08210	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DQW72_RS08215	COG0072	phenylalanine-tRNA ligase activity
DQW72_RS08215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DQW72_RS08220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DQW72_RS08225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DQW72_RS08240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DQW72_RS08255	COG1323	Belongs to the UPF0348 family
DQW72_RS08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DQW72_RS08265	COG0742	ribosomal rna small subunit methyltransferase
DQW72_RS08275	COG4471	UPF0298 protein
DQW72_RS08285	COG0584	glycerophosphoryl diester phosphodiesterase
DQW72_RS08290	COG3679	Belongs to the UPF0342 family
DQW72_RS08295	COG2340	Cysteine-rich secretory protein family
DQW72_RS08305	COG0109	protoheme IX farnesyltransferase activity
DQW72_RS08310	COG1612	heme a metabolic process
DQW72_RS08320	COG0772	Belongs to the SEDS family
DQW72_RS08325	COG4838	Belongs to the UPF0358 family
DQW72_RS08330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DQW72_RS08335	COG4896	Protein conserved in bacteria
DQW72_RS08350	COG1217	gtp-binding protein TYPA
DQW72_RS08360	COG0483	inositol monophosphate 1-phosphatase activity
DQW72_RS08365	COG4493	Belongs to the UPF0637 family
DQW72_RS08370	COG1914	H( )-stimulated, divalent metal cation uptake system
DQW72_RS08395	COG1176	ABC-type spermidine putrescine transport system, permease component I
DQW72_RS08400	COG3842	ATPase activity
DQW72_RS08410	COG4476	Belongs to the UPF0223 family
DQW72_RS08420	COG0508	dehydrogenase complex catalyzes the overall conversion of
DQW72_RS08425	COG0022	dehydrogenase e1 component
DQW72_RS08430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DQW72_RS08440	COG0242	peptide deformylase activity
DQW72_RS08445	COG5503	Protein of unknown function (DUF1447)
DQW72_RS08450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DQW72_RS08455	COG0569	domain protein
DQW72_RS08460	COG1294	oxidase, subunit
DQW72_RS08465	COG1271	oxidase subunit
DQW72_RS08475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DQW72_RS08480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DQW72_RS08490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DQW72_RS08505	COG4716	Myosin-crossreactive antigen
DQW72_RS08515	COG4172	Belongs to the ABC transporter superfamily
DQW72_RS08520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DQW72_RS08525	COG0151	Belongs to the GarS family
DQW72_RS08530	COG0138	bifunctional purine biosynthesis protein purh
DQW72_RS08535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DQW72_RS08540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DQW72_RS08545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DQW72_RS08550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DQW72_RS08555	COG0047	phosphoribosylformylglycinamidine synthase activity
DQW72_RS08560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DQW72_RS08565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DQW72_RS08570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DQW72_RS08575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DQW72_RS08580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DQW72_RS08590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DQW72_RS08595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DQW72_RS08600	COG1845	cytochrome c oxidase, subunit III
DQW72_RS08605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DQW72_RS08620	COG1316	TRANSCRIPTIONal
DQW72_RS08645	COG3594	Acyltransferase
DQW72_RS08650	COG0436	Aminotransferase
DQW72_RS08655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DQW72_RS08665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DQW72_RS08670	COG1169	isochorismate synthase
DQW72_RS08680	COG1575	Belongs to the MenA family. Type 1 subfamily
DQW72_RS08690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DQW72_RS08700	COG2314	TM2 domain
DQW72_RS08715	COG1279	arginine transmembrane transporter activity
DQW72_RS08760	COG4824	toxin secretion phage lysis holin
DQW72_RS08860	COG1595	DNA-templated transcription, initiation
DQW72_RS09010	COG4873	Protein conserved in bacteria
DQW72_RS09020	COG0737	Belongs to the 5'-nucleotidase family
DQW72_RS09025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DQW72_RS09030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DQW72_RS09035	COG0861	Integral membrane protein TerC family
DQW72_RS09040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DQW72_RS09050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DQW72_RS09055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DQW72_RS09060	COG2814	Major facilitator Superfamily
DQW72_RS09065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DQW72_RS09070	COG2382	esterase
DQW72_RS09075	COG0628	permease
DQW72_RS09105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DQW72_RS09105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DQW72_RS09115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DQW72_RS09120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DQW72_RS09125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DQW72_RS09130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DQW72_RS09160	COG0475	glutathione-regulated potassium exporter activity
DQW72_RS09160	COG0569	domain protein
DQW72_RS09165	COG2239	Acts as a magnesium transporter
DQW72_RS09170	COG0564	pseudouridine synthase activity
DQW72_RS09175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DQW72_RS09180	COG2357	RelA SpoT domain protein
DQW72_RS09195	COG2346	COG2346, Truncated hemoglobins
DQW72_RS09200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DQW72_RS09205	COG1164	Oligoendopeptidase f
DQW72_RS09215	COG4862	establishment of competence for transformation
DQW72_RS09220	COG1393	Belongs to the ArsC family
DQW72_RS09225	COG0180	Tryptophanyl-tRNA synthetase
DQW72_RS09230	COG4166	transmembrane transport
DQW72_RS09235	COG4608	Belongs to the ABC transporter superfamily
DQW72_RS09240	COG0444	Belongs to the ABC transporter superfamily
DQW72_RS09245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DQW72_RS09250	COG0601	transmembrane transport
DQW72_RS09265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DQW72_RS09285	COG0542	response to heat
DQW72_RS09300	COG0561	phosphatase activity
DQW72_RS09305	COG0446	pyridine nucleotide-disulphide oxidoreductase
DQW72_RS09320	COG0179	Fumarylacetoacetate (FAA) hydrolase
DQW72_RS09325	COG1074	ATP-dependent DNA helicase activity
DQW72_RS09330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DQW72_RS09345	COG0398	Pfam SNARE associated Golgi protein
DQW72_RS09350	COG0166	Belongs to the GPI family
DQW72_RS09355	COG0137	argininosuccinate synthase activity
DQW72_RS09360	COG0165	Argininosuccinate lyase
DQW72_RS09365	COG0584	glycerophosphoryl diester phosphodiesterase
DQW72_RS09375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DQW72_RS09385	COG1902	pentaerythritol trinitrate reductase activity
DQW72_RS09390	COG1098	S1 RNA binding domain
DQW72_RS09395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DQW72_RS09405	COG2111	Na H antiporter
DQW72_RS09405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DQW72_RS09410	COG2111	Na H antiporter
DQW72_RS09415	COG1006	Multisubunit Na H antiporter MnhC subunit
DQW72_RS09420	COG0651	ATP synthesis coupled electron transport
DQW72_RS09425	COG1863	multisubunit Na H antiporter MnhE subunit
DQW72_RS09430	COG2212	antiporter activity
DQW72_RS09435	COG1320	monovalent cation:proton antiporter activity
DQW72_RS09445	COG2050	protein possibly involved in aromatic compounds catabolism
DQW72_RS09450	COG2056	Na+-H+ antiporter family
DQW72_RS09455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DQW72_RS09460	COG1252	NADH dehydrogenase
DQW72_RS09465	COG0316	Belongs to the HesB IscA family
DQW72_RS09470	COG4844	belongs to the
DQW72_RS09475	COG1252	NADH dehydrogenase
DQW72_RS09480	COG4837	Protein of unknown function (DUF1462)
DQW72_RS09485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DQW72_RS09490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DQW72_RS09495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DQW72_RS09500	COG1696	Membrane protein involved in D-alanine export
DQW72_RS09505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DQW72_RS09515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DQW72_RS09520	COG0647	UMP catabolic process
DQW72_RS09525	COG2445	Protein of unknown function DUF86
DQW72_RS09535	COG4470	Protein conserved in bacteria
DQW72_RS09540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DQW72_RS09545	COG0737	Belongs to the 5'-nucleotidase family
DQW72_RS09550	COG0730	response to heat
DQW72_RS09555	COG1801	Protein of unknown function DUF72
DQW72_RS09560	COG1253	flavin adenine dinucleotide binding
DQW72_RS09575	COG0719	Fe-S assembly protein
DQW72_RS09580	COG0822	iron-sulfur transferase activity
DQW72_RS09585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DQW72_RS09590	COG0719	Fe-S assembly protein
DQW72_RS09595	COG0396	ATPase activity
DQW72_RS09605	COG3237	CsbD-like
DQW72_RS09615	COG1464	Belongs to the NlpA lipoprotein family
DQW72_RS09620	COG2011	ABC-type metal ion transport system permease component
DQW72_RS09625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DQW72_RS09635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DQW72_RS09645	COG0509	glycine decarboxylation via glycine cleavage system
DQW72_RS09650	COG1393	Belongs to the ArsC family
DQW72_RS09655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DQW72_RS09665	COG0710	3-dehydroquinate dehydratase activity
DQW72_RS09670	COG1764	response to oxidative stress
DQW72_RS09725	COG4195	phage-related replication protein
DQW72_RS09740	COG1278	Cold shock
DQW72_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DQW72_RS09825	COG3728	DNA packaging
DQW72_RS09825	COG5484	DNA packaging
DQW72_RS09890	COG0582	viral genome integration into host DNA
DQW72_RS09905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DQW72_RS09910	COG0557	exoribonuclease II activity
DQW72_RS09915	COG1647	Serine aminopeptidase, S33
DQW72_RS09920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DQW72_RS09930	COG0148	phosphopyruvate hydratase activity
DQW72_RS09935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DQW72_RS09940	COG0149	triose-phosphate isomerase activity
DQW72_RS09945	COG0126	phosphoglycerate kinase activity
DQW72_RS09950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DQW72_RS09970	COG1090	epimerase
DQW72_RS09980	COG0740	serine-type endopeptidase activity
DQW72_RS09990	COG1481	regulation of sporulation
DQW72_RS09995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DQW72_RS10000	COG1660	Displays ATPase and GTPase activities
DQW72_RS10005	COG0492	ferredoxin-NADP+ reductase activity
DQW72_RS10020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DQW72_RS10025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DQW72_RS10030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DQW72_RS10035	COG0556	nucleotide-excision repair
DQW72_RS10055	COG3942	CHAP domain
DQW72_RS10055	COG1388	LysM domain
DQW72_RS10065	COG0653	protein targeting
DQW72_RS10070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DQW72_RS10075	COG1040	competence protein
DQW72_RS10080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DQW72_RS10090	COG1739	Uncharacterized protein family UPF0029
DQW72_RS10095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DQW72_RS10100	COG2199	diguanylate cyclase activity
DQW72_RS10115	COG2195	Cleaves the N-terminal amino acid of tripeptides
DQW72_RS10120	COG1929	Belongs to the glycerate kinase type-1 family
DQW72_RS10140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DQW72_RS10155	COG4604	ABC transporter, ATP-binding protein
DQW72_RS10160	COG4605	iron ion homeostasis
DQW72_RS10165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DQW72_RS10175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DQW72_RS10180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DQW72_RS10185	COG1780	Probably involved in ribonucleotide reductase function
DQW72_RS10195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DQW72_RS10200	COG3104	oligopeptide transport
DQW72_RS10205	COG1597	lipid kinase activity
DQW72_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
DQW72_RS10210	COG1454	alcohol dehydrogenase
DQW72_RS10215	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
DQW72_RS10220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DQW72_RS10225	COG1174	glycine betaine transport
DQW72_RS10235	COG0514	ATP-dependent DNA helicase (RecQ)
DQW72_RS10240	COG0488	(ABC) transporter
DQW72_RS10255	COG1368	sulfuric ester hydrolase activity
DQW72_RS10265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DQW72_RS10280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DQW72_RS10290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DQW72_RS10295	COG0720	synthase
DQW72_RS10300	COG0602	queuosine metabolic process
DQW72_RS10325	COG0745	RESPONSE REGULATOR receiver
DQW72_RS10330	COG5002	protein histidine kinase activity
DQW72_RS10335	COG0463	Glycosyl transferase, family 2
DQW72_RS10345	COG0656	L-ascorbic acid biosynthetic process
DQW72_RS10350	COG1253	flavin adenine dinucleotide binding
DQW72_RS10355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DQW72_RS10360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DQW72_RS10360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DQW72_RS10360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DQW72_RS10365	COG1105	Belongs to the carbohydrate kinase PfkB family
DQW72_RS10370	COG1349	DNA-binding transcription factor activity
DQW72_RS10380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DQW72_RS10405	COG0415	Belongs to the DNA photolyase family
DQW72_RS10410	COG0471	metal ion transport
DQW72_RS10415	COG0039	L-malate dehydrogenase activity
DQW72_RS10440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DQW72_RS10445	COG4988	ABC transporter
DQW72_RS10450	COG1968	undecaprenyl-diphosphatase activity
DQW72_RS10465	COG1671	Belongs to the UPF0178 family
DQW72_RS10470	COG1611	Belongs to the LOG family
DQW72_RS10495	COG2839	Protein conserved in bacteria
DQW72_RS10500	COG2814	Major facilitator Superfamily
DQW72_RS10505	COG0583	DNA-binding transcription factor activity
DQW72_RS10525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DQW72_RS10535	COG0217	transcriptional regulatory protein
DQW72_RS10555	COG1388	LysM domain
DQW72_RS10555	COG3942	CHAP domain
DQW72_RS10560	COG0306	phosphate transporter
DQW72_RS10565	COG1392	Phosphate transport regulator
DQW72_RS10570	COG0577	efflux transmembrane transporter activity
DQW72_RS10575	COG1136	(ABC) transporter
DQW72_RS10580	COG2205	protein histidine kinase activity
DQW72_RS10585	COG0745	RESPONSE REGULATOR receiver
DQW72_RS10590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DQW72_RS10605	COG3949	Membrane
DQW72_RS10615	COG1120	ATPase activity
DQW72_RS10620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DQW72_RS10630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DQW72_RS10635	COG1132	(ABC) transporter
DQW72_RS10650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DQW72_RS10660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DQW72_RS10665	COG1682	transport, permease protein
DQW72_RS10670	COG1134	teichoic acid transport
DQW72_RS10675	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DQW72_RS10685	COG1321	iron dependent repressor
DQW72_RS10690	COG1121	(ABC) transporter
DQW72_RS10695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DQW72_RS10700	COG0803	Belongs to the bacterial solute-binding protein 9 family
DQW72_RS10710	COG1320	monovalent cation:proton antiporter activity
DQW72_RS10715	COG2212	antiporter activity
DQW72_RS10720	COG1863	multisubunit Na H antiporter MnhE subunit
DQW72_RS10725	COG0651	ATP synthesis coupled electron transport
DQW72_RS10730	COG1006	Multisubunit Na H antiporter MnhC subunit
DQW72_RS10735	COG2111	Na H antiporter
DQW72_RS10740	COG2111	Na H antiporter
DQW72_RS10740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DQW72_RS10780	COG0596	Alpha beta hydrolase
DQW72_RS10800	COG0546	phosphoglycolate phosphatase activity
DQW72_RS10805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DQW72_RS10810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DQW72_RS10825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DQW72_RS10830	COG0018	arginyl-trna synthetase
DQW72_RS10855	COG1064	alcohol dehydrogenase
DQW72_RS10860	COG3875	lactate racemase activity
DQW72_RS10865	COG1606	tRNA processing
DQW72_RS10870	COG1691	(AIR) carboxylase
DQW72_RS10875	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DQW72_RS10885	COG1078	dGTPase activity
DQW72_RS10905	COG2113	Glycine betaine
DQW72_RS10910	COG2409	Drug exporters of the RND superfamily
DQW72_RS10915	COG0667	Aldo Keto reductase
DQW72_RS10925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DQW72_RS10930	COG4844	belongs to the
DQW72_RS10950	COG0095	Lipoate-protein ligase
DQW72_RS10955	COG0280	phosphate acetyltransferase
DQW72_RS10960	COG3253	May function as heme-dependent peroxidase
DQW72_RS10980	COG0531	amino acid
DQW72_RS10985	COG2363	Small membrane protein
DQW72_RS10995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DQW72_RS11005	COG0351	phosphomethylpyrimidine kinase
DQW72_RS11025	COG0183	Belongs to the thiolase family
DQW72_RS11030	COG0318	PFAM AMP-dependent synthetase and ligase
DQW72_RS11040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DQW72_RS11045	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DQW72_RS11050	COG0363	glucosamine-6-phosphate deaminase activity
DQW72_RS11060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DQW72_RS11065	COG1469	GTP cyclohydrolase I activity
DQW72_RS11075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DQW72_RS11080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DQW72_RS11085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DQW72_RS11100	COG0431	NADPH-dependent FMN reductase
DQW72_RS11105	COG0561	phosphatase activity
DQW72_RS11120	COG1428	Deoxynucleoside kinase
DQW72_RS11125	COG1428	Deoxynucleoside kinase
DQW72_RS11135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DQW72_RS11145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DQW72_RS11150	COG1063	alcohol dehydrogenase
DQW72_RS11155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DQW72_RS11160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DQW72_RS11165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DQW72_RS11185	COG1473	amidohydrolase
DQW72_RS11190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DQW72_RS11195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DQW72_RS11205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DQW72_RS11215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DQW72_RS11220	COG0085	RNA polymerase activity
DQW72_RS11225	COG2813	Specifically methylates the guanine in position
DQW72_RS11230	COG0222	ribosome binding
DQW72_RS11235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DQW72_RS11245	COG0081	regulation of translation
DQW72_RS11250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DQW72_RS11255	COG0250	Participates in transcription elongation, termination and antitermination
DQW72_RS11260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DQW72_RS11265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DQW72_RS11275	COG3688	RNA-binding protein containing a PIN domain
DQW72_RS11280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DQW72_RS11285	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DQW72_RS11290	COG0215	cysteine-tRNA ligase activity
DQW72_RS11295	COG1045	serine acetyltransferase
DQW72_RS11300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DQW72_RS11305	COG4956	integral membrane protein (PIN domain superfamily)
DQW72_RS11310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DQW72_RS11315	COG0542	response to heat
DQW72_RS11320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DQW72_RS11325	COG3880	PFAM UvrB UvrC protein
DQW72_RS11330	COG4463	regulation of RNA biosynthetic process
DQW72_RS11335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DQW72_RS11345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DQW72_RS11350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DQW72_RS11355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DQW72_RS11440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DQW72_RS11445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DQW72_RS11450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DQW72_RS11455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DQW72_RS11460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DQW72_RS11465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DQW72_RS11470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DQW72_RS11475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DQW72_RS11480	COG0037	tRNA processing
DQW72_RS11485	COG1098	S1 RNA binding domain
DQW72_RS11495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DQW72_RS11500	COG3956	TIGRFAM MazG family protein
DQW72_RS11505	COG2244	polysaccharide biosynthetic process
DQW72_RS11510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DQW72_RS11515	COG0193	aminoacyl-tRNA hydrolase activity
DQW72_RS11520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DQW72_RS11525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DQW72_RS11530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DQW72_RS11535	COG2088	sporulation resulting in formation of a cellular spore
DQW72_RS11540	COG0251	oxidation-reduction process
DQW72_RS11545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DQW72_RS11550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DQW72_RS11555	COG4466	Protein conserved in bacteria
DQW72_RS11560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DQW72_RS11565	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DQW72_RS11570	COG0084	hydrolase, TatD family'
DQW72_RS11575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DQW72_RS11575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DQW72_RS11580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DQW72_RS11585	COG2827	Endonuclease containing a URI domain
DQW72_RS11590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DQW72_RS11595	COG4467	Involved in initiation control of chromosome replication
DQW72_RS11600	COG1774	PSP1 C-terminal conserved region
DQW72_RS11605	COG0470	DNA polymerase III
DQW72_RS11610	COG3870	Protein conserved in bacteria
DQW72_RS11615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DQW72_RS11620	COG1982	Orn Lys Arg decarboxylase major
DQW72_RS11645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DQW72_RS11650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DQW72_RS11655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DQW72_RS11675	COG2855	membrane
DQW72_RS11680	COG0583	DNA-binding transcription factor activity
DQW72_RS11690	COG0493	'glutamate synthase
DQW72_RS11695	COG0067	glutamate synthase
DQW72_RS11695	COG0069	glutamate synthase activity
DQW72_RS11695	COG0070	glutamate synthase
DQW72_RS11700	COG0583	DNA-binding transcription factor activity
DQW72_RS11725	COG0438	transferase activity, transferring glycosyl groups
DQW72_RS11730	COG3942	CHAP domain
DQW72_RS11730	COG1388	LysM domain
DQW72_RS11740	COG2011	ABC-type metal ion transport system permease component
DQW72_RS11745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DQW72_RS11750	COG0626	cystathionine gamma-synthase activity
DQW72_RS11755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DQW72_RS11765	COG0733	neurotransmitter:sodium symporter activity
DQW72_RS11775	COG1647	Serine aminopeptidase, S33
DQW72_RS11790	COG5609	conserved protein (DUF2294)
DQW72_RS11800	COG3002	Belongs to the UPF0753 family
DQW72_RS11805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DQW72_RS11825	COG0523	cobalamin synthesis protein
DQW72_RS11880	COG0519	Catalyzes the synthesis of GMP from XMP
DQW72_RS11880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DQW72_RS11885	COG0516	GMP reductase activity
DQW72_RS11885	COG0517	IMP dehydrogenase activity
DQW72_RS11890	COG2233	PERMEase
DQW72_RS11895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DQW72_RS11910	COG5183	chlorophyll binding
DQW72_RS11920	COG1823	symporter activity
DQW72_RS11925	COG0778	Nitroreductase
DQW72_RS11935	COG0450	alkyl hydroperoxide reductase
DQW72_RS11940	COG3634	alkyl hydroperoxide reductase activity
DQW72_RS11975	COG1280	lysine exporter protein (LysE YggA)
DQW72_RS12000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DQW72_RS12010	COG0360	Binds together with S18 to 16S ribosomal RNA
DQW72_RS12025	COG0012	GTP binding
DQW72_RS12030	COG4481	Protein conserved in bacteria
DQW72_RS12035	COG0668	transmembrane transport
DQW72_RS12040	COG1475	DNA binding
DQW72_RS12050	COG0626	cystathionine gamma-synthase activity
DQW72_RS12055	COG0626	cystathionine gamma-synthase activity
DQW72_RS12060	COG0646	methionine synthase
DQW72_RS12060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DQW72_RS12065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DQW72_RS12075	COG0183	Belongs to the thiolase family
DQW72_RS12090	COG1476	TRANSCRIPTIONal
DQW72_RS12100	COG4555	ABC transporter
DQW72_RS12170	COG1136	(ABC) transporter
DQW72_RS12175	COG0577	efflux transmembrane transporter activity
DQW72_RS12195	COG0577	efflux transmembrane transporter activity
DQW72_RS12200	COG1136	(ABC) transporter
DQW72_RS12240	COG1475	DNA binding
DQW72_RS12245	COG0357	Ribosomal RNA small subunit methyltransferase G
DQW72_RS12250	COG0445	tRNA wobble uridine modification
DQW72_RS12255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DQW72_RS12260	COG0594	ribonuclease P activity
DQW72_RS12310	COG3173	Aminoglycoside phosphotransferase
DQW72_RS12335	COG1230	cation diffusion facilitator family transporter
DQW72_RS12345	COG1937	Protein conserved in bacteria
DQW72_RS12350	COG2217	Heavy metal translocating P-type atpase
DQW72_RS12500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DQW72_RS12505	COG0803	Belongs to the bacterial solute-binding protein 9 family
DQW72_RS12555	COG1136	(ABC) transporter
DQW72_RS12555	COG0577	efflux transmembrane transporter activity