locus-tag	class	description
AL514_RS00150	COG3682	Transcriptional regulator
AL514_RS00185	COG1396	sequence-specific DNA binding
AL514_RS00225	COG2211	Major facilitator Superfamily
AL514_RS00320	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL514_RS00325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL514_RS00330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL514_RS00335	COG2329	Antibiotic biosynthesis monooxygenase
AL514_RS00345	COG4473	ABC transporter
AL514_RS00350	COG1131	(ABC) transporter
AL514_RS00355	COG0537	adenosine 5'-monophosphoramidase activity
AL514_RS00370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL514_RS00380	COG3481	metal-dependent phosphohydrolase, HD sub domain
AL514_RS00390	COG0420	3'-5' exonuclease activity
AL514_RS00395	COG3679	Belongs to the UPF0342 family
AL514_RS00400	COG4399	Belongs to the UPF0754 family
AL514_RS00410	COG2197	response regulator
AL514_RS00415	COG4585	Histidine kinase
AL514_RS00415	COG2203	Gaf domain
AL514_RS00420	COG0564	pseudouridine synthase activity
AL514_RS00425	COG0114	fumarate hydratase activity
AL514_RS00450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL514_RS00455	COG1126	abc transporter atp-binding protein
AL514_RS00460	COG0765	amino acid transport
AL514_RS00620	COG0735	belongs to the Fur family
AL514_RS00625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL514_RS00630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL514_RS00635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL514_RS00640	COG4129	membrane
AL514_RS00650	COG3557	Belongs to the UPF0374 family
AL514_RS00660	COG1988	membrane-bound metal-dependent
AL514_RS00670	COG1388	LysM domain
AL514_RS00670	COG1134	teichoic acid transport
AL514_RS00680	COG2137	regulation of response to DNA damage stimulus
AL514_RS00685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL514_RS00690	COG0693	protein deglycase activity
AL514_RS00700	COG0535	radical SAM domain protein
AL514_RS00705	COG1607	acyl-coa hydrolase
AL514_RS00710	COG2309	aminopeptidase activity
AL514_RS00715	COG4840	Belongs to the UPF0435 family
AL514_RS00720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL514_RS00730	COG1295	ribonuclease BN
AL514_RS00735	COG2197	response regulator
AL514_RS00740	COG4585	Histidine kinase
AL514_RS00755	COG0024	Methionine aminopeptidase
AL514_RS00760	COG4129	membrane
AL514_RS00780	COG1528	Iron-storage protein
AL514_RS00790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL514_RS00800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL514_RS00805	COG1597	lipid kinase activity
AL514_RS00810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL514_RS00815	COG0154	amidase activity
AL514_RS00820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL514_RS00825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL514_RS00830	COG4851	CamS sex pheromone cAM373 precursor
AL514_RS00835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL514_RS00840	COG0210	DNA helicase
AL514_RS00845	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AL514_RS00850	COG4496	protein, YerC YecD
AL514_RS00855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL514_RS00865	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AL514_RS00870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL514_RS00875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL514_RS00885	COG0077	Prephenate dehydratase
AL514_RS00895	COG1335	isochorismatase
AL514_RS00900	COG1227	inorganic diphosphatase activity
AL514_RS00905	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS00910	COG2706	6-phosphogluconolactonase activity
AL514_RS00920	COG3682	Transcriptional regulator
AL514_RS00950	COG4974	Belongs to the 'phage' integrase family
AL514_RS01000	COG1131	(ABC) transporter
AL514_RS01010	COG1131	(ABC) transporter
AL514_RS01015	COG1725	Transcriptional regulator
AL514_RS01035	COG0459	protein refolding
AL514_RS01040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL514_RS01075	COG3290	protein histidine kinase activity
AL514_RS01080	COG3279	Response regulator of the LytR AlgR family
AL514_RS01085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL514_RS01090	COG1621	beta-fructofuranosidase activity
AL514_RS01100	COG1609	Transcriptional regulator
AL514_RS01105	COG0004	ammonium transporteR
AL514_RS01110	COG0425	Belongs to the sulfur carrier protein TusA family
AL514_RS01115	COG2391	methyltransferase activity
AL514_RS01125	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AL514_RS01130	COG0488	(ABC) transporter
AL514_RS01135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL514_RS01140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL514_RS01145	COG0456	acetyltransferase
AL514_RS01150	COG1214	PFAM Peptidase M22, glycoprotease
AL514_RS01155	COG0802	atpase or kinase
AL514_RS01160	COG0129	dihydroxy-acid dehydratase activity
AL514_RS01165	COG0028	Belongs to the TPP enzyme family
AL514_RS01175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL514_RS01180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL514_RS01185	COG0473	3-isopropylmalate dehydrogenase activity
AL514_RS01190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL514_RS01200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL514_RS01240	COG3091	SprT-like family
AL514_RS01245	COG2183	response to ionizing radiation
AL514_RS01250	COG1191	sigma factor activity
AL514_RS01265	COG2208	phosphoserine phosphatase activity
AL514_RS01270	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL514_RS01280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL514_RS01285	COG0736	holo-[acyl-carrier-protein] synthase activity
AL514_RS01290	COG3402	PFAM membrane-flanked domain
AL514_RS01295	COG3428	Bacterial PH domain
AL514_RS01305	COG0513	Belongs to the DEAD box helicase family
AL514_RS01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL514_RS01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL514_RS01320	COG0772	Belongs to the SEDS family
AL514_RS01335	COG1937	Protein conserved in bacteria
AL514_RS01340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL514_RS01345	COG1418	mRNA catabolic process
AL514_RS01350	COG0706	membrane insertase activity
AL514_RS01355	COG0352	thiamine-phosphate diphosphorylase activity
AL514_RS01360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL514_RS01370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL514_RS01375	COG1388	LysM domain
AL514_RS01380	COG0629	single-stranded DNA binding
AL514_RS01390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL514_RS01395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL514_RS01405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL514_RS01410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL514_RS01415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL514_RS01420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL514_RS01425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL514_RS01430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL514_RS01440	COG0356	it plays a direct role in the translocation of protons across the membrane
AL514_RS01450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL514_RS01455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL514_RS01460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL514_RS01465	COG4475	Protein of unknown function (DUF436)
AL514_RS01470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL514_RS01475	COG0009	L-threonylcarbamoyladenylate synthase
AL514_RS01485	COG2890	protein-(glutamine-N5) methyltransferase activity
AL514_RS01490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL514_RS01495	COG1435	thymidine kinase activity
AL514_RS01505	COG0254	rRNA binding
AL514_RS01510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL514_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS01520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL514_RS01525	COG0191	fructose-bisphosphate aldolase activity
AL514_RS01535	COG0504	CTP synthase activity
AL514_RS01540	COG3343	RNA polymerase activity
AL514_RS01550	COG5146	pantothenate kinase activity
AL514_RS01570	COG1854	S-ribosylhomocysteine lyase activity
AL514_RS01580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL514_RS01585	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL514_RS01590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL514_RS01595	COG0813	purine-nucleoside phosphorylase activity
AL514_RS01600	COG0783	Belongs to the Dps family
AL514_RS01625	COG1482	cell wall glycoprotein biosynthetic process
AL514_RS01635	COG0702	epimerase
AL514_RS01640	COG0640	Transcriptional regulator
AL514_RS01660	COG0561	phosphatase activity
AL514_RS01665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL514_RS01670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL514_RS01680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AL514_RS01730	COG0489	protein tyrosine kinase activity
AL514_RS01735	COG2814	Major facilitator Superfamily
AL514_RS01755	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AL514_RS01760	COG1988	membrane-bound metal-dependent
AL514_RS01770	COG2329	Antibiotic biosynthesis monooxygenase
AL514_RS01775	COG3314	Sporulation integral membrane protein YlbJ
AL514_RS01780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL514_RS01785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL514_RS01790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL514_RS01795	COG3457	Alanine racemase
AL514_RS01800	COG4264	IucA IucC family
AL514_RS01805	COG2814	Major facilitator Superfamily
AL514_RS01810	COG4264	IucA IucC family
AL514_RS01815	COG1302	Protein conserved in bacteria
AL514_RS01830	COG0604	alcohol dehydrogenase
AL514_RS01835	COG2130	NADP-dependent
AL514_RS01840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL514_RS01850	COG2723	6-phospho-beta-galactosidase activity
AL514_RS01855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL514_RS01855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL514_RS01860	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL514_RS01865	COG3684	Belongs to the aldolase LacD family
AL514_RS01870	COG1105	Belongs to the carbohydrate kinase PfkB family
AL514_RS01875	COG0698	ribose 5-phosphate isomerase
AL514_RS01880	COG0698	ribose 5-phosphate isomerase
AL514_RS01885	COG1349	DNA-binding transcription factor activity
AL514_RS01890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL514_RS01895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL514_RS01900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL514_RS01905	COG0101	tRNA pseudouridine synthase activity
AL514_RS01915	COG1122	ATPase activity
AL514_RS01920	COG1122	ATPase activity
AL514_RS01925	COG0203	ribosomal protein L17
AL514_RS01930	COG0202	RNA polymerase activity
AL514_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL514_RS01940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL514_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL514_RS01950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL514_RS01955	COG0563	adenylate kinase activity
AL514_RS01960	COG0201	protein transport
AL514_RS01965	COG0200	Binds to the 23S rRNA
AL514_RS01970	COG1841	ribosomal large subunit assembly
AL514_RS01975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL514_RS01980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL514_RS01985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL514_RS01990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL514_RS01995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL514_RS02000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL514_RS02005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL514_RS02010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL514_RS02015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL514_RS02025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL514_RS02030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL514_RS02035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL514_RS02040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL514_RS02045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL514_RS02050	COG0089	rRNA binding
AL514_RS02055	COG0088	Forms part of the polypeptide exit tunnel
AL514_RS02060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL514_RS02075	COG2252	PERMEase
AL514_RS02080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL514_RS02080	COG0551	DNA topoisomerase type I activity
AL514_RS02085	COG4975	Glucose uptake
AL514_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS02110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL514_RS02115	COG2348	transferase activity, transferring amino-acyl groups
AL514_RS02150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL514_RS02155	COG0746	molybdenum cofactor guanylyltransferase activity
AL514_RS02165	COG0314	molybdopterin synthase activity
AL514_RS02175	COG0303	'Molybdopterin
AL514_RS02180	COG0315	cyclic pyranopterin monophosphate synthase activity
AL514_RS02185	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL514_RS02190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL514_RS02195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL514_RS02200	COG4149	molybdate abc transporter
AL514_RS02205	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL514_RS02210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL514_RS02215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL514_RS02230	COG1268	BioY protein
AL514_RS02235	COG1957	nucleoside hydrolase
AL514_RS02240	COG1960	acyl-CoA dehydrogenase activity
AL514_RS02255	COG0831	urea catabolic process
AL514_RS02260	COG0832	Belongs to the urease beta subunit family
AL514_RS02265	COG0804	urea catabolic process
AL514_RS02270	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL514_RS02275	COG0830	nickel cation binding
AL514_RS02280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL514_RS02285	COG0829	nickel cation binding
AL514_RS02310	COG3942	CHAP domain
AL514_RS02315	COG1757	Na H antiporter
AL514_RS02330	COG3942	CHAP domain
AL514_RS02335	COG2076	Multidrug Resistance protein
AL514_RS02340	COG2076	Multidrug Resistance protein
AL514_RS02345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL514_RS02370	COG1316	TRANSCRIPTIONal
AL514_RS02375	COG0483	inositol monophosphate 1-phosphatase activity
AL514_RS02380	COG2378	regulation of single-species biofilm formation
AL514_RS02385	COG1266	CAAX protease self-immunity
AL514_RS02400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL514_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL514_RS02405	COG1263	PTS System
AL514_RS02415	COG1113	amino acid transport
AL514_RS02450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL514_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS02460	COG1473	amidohydrolase
AL514_RS02465	COG0010	Belongs to the arginase family
AL514_RS02470	COG1266	CAAX protease self-immunity
AL514_RS02485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL514_RS02490	COG2258	MOSC domain
AL514_RS02495	COG2017	converts alpha-aldose to the beta-anomer
AL514_RS02500	COG1069	ribulokinase activity
AL514_RS02525	COG2094	Belongs to the DNA glycosylase MPG family
AL514_RS02545	COG0786	glutamate:sodium symporter activity
AL514_RS02550	COG1304	FMN binding
AL514_RS02555	COG0598	Magnesium transport protein CorA
AL514_RS02570	COG0657	acetylesterase activity
AL514_RS02585	COG2814	Major facilitator Superfamily
AL514_RS02590	COG1566	PFAM secretion protein HlyD family protein
AL514_RS02600	COG2814	Major facilitator Superfamily
AL514_RS02605	COG4640	response to antibiotic
AL514_RS02620	COG1136	(ABC) transporter
AL514_RS02625	COG0577	efflux transmembrane transporter activity
AL514_RS02630	COG0745	RESPONSE REGULATOR receiver
AL514_RS02635	COG5002	protein histidine kinase activity
AL514_RS02635	COG3850	Histidine kinase
AL514_RS02640	COG0579	oxidoreductase
AL514_RS02645	COG0438	transferase activity, transferring glycosyl groups
AL514_RS02650	COG1620	l-lactate permease
AL514_RS02655	COG0463	Glycosyl transferase, family 2
AL514_RS02655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL514_RS02665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL514_RS02665	COG0463	Glycosyl transferase, family 2
AL514_RS02670	COG0456	acetyltransferase
AL514_RS02675	COG0604	alcohol dehydrogenase
AL514_RS02720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL514_RS02720	COG1263	PTS System
AL514_RS02735	COG3871	stress protein (general stress protein 26)
AL514_RS02755	COG0778	Nitroreductase
AL514_RS02760	COG1846	Transcriptional regulator
AL514_RS02765	COG2223	nitrite transmembrane transporter activity
AL514_RS02770	COG2197	response regulator
AL514_RS02775	COG4585	Histidine kinase
AL514_RS02785	COG2181	nitrate reductase activity
AL514_RS02795	COG1140	nitrate reductase beta subunit
AL514_RS02800	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL514_RS02810	COG2146	nitrite reductase [NAD(P)H] activity
AL514_RS02815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL514_RS02830	COG0747	negative chemotaxis
AL514_RS02835	COG0454	-acetyltransferase
AL514_RS02840	COG2116	formate transmembrane transporter activity
AL514_RS02860	COG2348	transferase activity, transferring amino-acyl groups
AL514_RS02865	COG1126	abc transporter atp-binding protein
AL514_RS02870	COG0765	amino acid transport
AL514_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL514_RS02885	COG0588	phosphoglycerate mutase activity
AL514_RS02890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL514_RS02905	COG1929	Belongs to the glycerate kinase type-1 family
AL514_RS02930	COG1113	amino acid transport
AL514_RS02935	COG0531	amino acid
AL514_RS02945	COG0706	membrane insertase activity
AL514_RS02950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL514_RS02960	COG3275	phosphorelay sensor kinase activity
AL514_RS02965	COG3279	Response regulator of the LytR AlgR family
AL514_RS02970	COG1380	Effector of murein hydrolase LrgA
AL514_RS02975	COG1346	cytolysis
AL514_RS02980	COG1174	glycine betaine transport
AL514_RS03000	COG1063	alcohol dehydrogenase
AL514_RS03010	COG0531	amino acid
AL514_RS03015	COG2272	Belongs to the type-B carboxylesterase lipase family
AL514_RS03020	COG2814	Major facilitator Superfamily
AL514_RS03025	COG0390	transport system, permease component
AL514_RS03030	COG4619	ABC transporter
AL514_RS03050	COG0069	glutamate synthase activity
AL514_RS03060	COG1363	Peptidase, m42
AL514_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS03080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL514_RS03085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL514_RS03090	COG4221	oxidoreductase activity
AL514_RS03100	COG0556	nucleotide-excision repair
AL514_RS03105	COG0494	nUDIX hydrolase
AL514_RS03110	COG0438	transferase activity, transferring glycosyl groups
AL514_RS03115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL514_RS03120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL514_RS03125	COG2610	gluconate transmembrane transporter activity
AL514_RS03135	COG1802	Transcriptional regulator
AL514_RS03140	COG2271	Major facilitator Superfamily
AL514_RS03145	COG0789	Transcriptional regulator
AL514_RS03165	COG2357	RelA SpoT domain protein
AL514_RS03170	COG4876	unkown
AL514_RS03185	COG2271	Major facilitator Superfamily
AL514_RS03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL514_RS03205	COG2022	thiamine diphosphate biosynthetic process
AL514_RS03210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL514_RS03215	COG0586	Pfam SNARE associated Golgi protein
AL514_RS03220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AL514_RS03235	COG3949	Membrane
AL514_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS03255	COG2514	catechol 2,3-dioxygenase activity
AL514_RS03265	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS03275	COG0778	Nitroreductase
AL514_RS03280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL514_RS03290	COG3764	Sortase (surface protein transpeptidase)
AL514_RS03310	COG1760	l-serine dehydratase
AL514_RS03315	COG1760	l-serine dehydratase
AL514_RS03335	COG1070	Carbohydrate kinase
AL514_RS03345	COG1869	D-ribose catabolic process
AL514_RS03350	COG4975	Glucose uptake
AL514_RS03365	COG2843	Capsule synthesis protein
AL514_RS03375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL514_RS03390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL514_RS03400	COG1063	alcohol dehydrogenase
AL514_RS03420	COG1263	PTS System
AL514_RS03420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL514_RS03420	COG2190	(PTS) system
AL514_RS03425	COG0028	Belongs to the TPP enzyme family
AL514_RS03430	COG1346	cytolysis
AL514_RS03435	COG1380	Effector of murein hydrolase LrgA
AL514_RS03440	COG0583	DNA-binding transcription factor activity
AL514_RS03460	COG3425	synthase
AL514_RS03465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL514_RS03490	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS03505	COG2217	Heavy metal translocating P-type atpase
AL514_RS03510	COG2608	mercury ion transmembrane transporter activity
AL514_RS03520	COG0436	Aminotransferase
AL514_RS03530	COG3942	CHAP domain
AL514_RS03540	COG0741	lytic transglycosylase activity
AL514_RS03560	COG1113	amino acid transport
AL514_RS03565	COG3001	Fructosamine kinase
AL514_RS03570	COG0167	dihydroorotate dehydrogenase activity
AL514_RS03580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL514_RS03595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL514_RS03600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL514_RS03605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL514_RS03615	COG3527	Alpha-acetolactate decarboxylase
AL514_RS03620	COG0028	Belongs to the TPP enzyme family
AL514_RS03625	COG0039	L-malate dehydrogenase activity
AL514_RS03630	COG0583	DNA-binding transcription factor activity
AL514_RS03635	COG0531	amino acid
AL514_RS03670	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL514_RS03680	COG3588	fructose-bisphosphate aldolase
AL514_RS03690	COG0579	oxidoreductase
AL514_RS03695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL514_RS03700	COG0574	Belongs to the PEP-utilizing enzyme family
AL514_RS03700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL514_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL514_RS03720	COG1473	amidohydrolase
AL514_RS03725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL514_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS03735	COG1510	regulation of RNA biosynthetic process
AL514_RS03750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL514_RS03755	COG0602	queuosine metabolic process
AL514_RS03760	COG1328	CTP reductase activity
AL514_RS03770	COG0529	Catalyzes the synthesis of activated sulfate
AL514_RS03775	COG2046	Belongs to the sulfate adenylyltransferase family
AL514_RS03780	COG0730	response to heat
AL514_RS03795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL514_RS03800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL514_RS03805	COG0175	sulfate reduction
AL514_RS03815	COG0386	Belongs to the glutathione peroxidase family
AL514_RS03825	COG1846	Transcriptional regulator
AL514_RS03850	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL514_RS03865	COG1136	(ABC) transporter
AL514_RS03870	COG2205	protein histidine kinase activity
AL514_RS03885	COG1785	Belongs to the alkaline phosphatase family
AL514_RS03890	COG0702	epimerase
AL514_RS03895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL514_RS03905	COG4195	phage-related replication protein
AL514_RS03940	COG1397	ADP-ribosylglycohydrolase
AL514_RS03970	COG0640	Transcriptional regulator
AL514_RS04005	COG0583	DNA-binding transcription factor activity
AL514_RS04025	COG0659	secondary active sulfate transmembrane transporter activity
AL514_RS04060	COG3961	Belongs to the TPP enzyme family
AL514_RS04070	COG2843	Capsule synthesis protein
AL514_RS04080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL514_RS04090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL514_RS04100	COG1438	arginine binding
AL514_RS04105	COG3227	Zinc metalloprotease (Elastase)
AL514_RS04110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL514_RS04145	COG3711	transcriptional antiterminator
AL514_RS04145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL514_RS04150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL514_RS04150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL514_RS04150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL514_RS04155	COG1482	cell wall glycoprotein biosynthetic process
AL514_RS04165	COG3942	CHAP domain
AL514_RS04165	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL514_RS04175	COG1764	response to oxidative stress
AL514_RS04190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL514_RS04195	COG2814	Major facilitator Superfamily
AL514_RS04220	COG0438	transferase activity, transferring glycosyl groups
AL514_RS04225	COG0653	protein targeting
AL514_RS04235	COG1073	alpha beta
AL514_RS04245	COG0201	protein transport
AL514_RS04265	COG3639	organic phosphonate transmembrane transporter activity
AL514_RS04270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL514_RS04285	COG0737	Belongs to the 5'-nucleotidase family
AL514_RS04290	COG2814	Major facilitator Superfamily
AL514_RS04310	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL514_RS04320	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL514_RS04325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL514_RS04325	COG0140	phosphoribosyl-ATP diphosphatase activity
AL514_RS04330	COG0107	imidazoleglycerol-phosphate synthase activity
AL514_RS04335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL514_RS04340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL514_RS04345	COG0131	Imidazoleglycerol-phosphate dehydratase
AL514_RS04350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL514_RS04355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL514_RS04360	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AL514_RS04385	COG0579	oxidoreductase
AL514_RS04395	COG2353	YceI-like domain
AL514_RS04400	COG3386	PFAM SMP-30 Gluconolaconase
AL514_RS04405	COG1054	Belongs to the UPF0176 family
AL514_RS04410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL514_RS04430	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL514_RS04435	COG0022	dehydrogenase e1 component
AL514_RS04440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL514_RS04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL514_RS04450	COG0471	metal ion transport
AL514_RS04455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL514_RS04460	COG2962	Rard protein
AL514_RS04475	COG2814	Major facilitator Superfamily
AL514_RS04510	COG2814	Major facilitator Superfamily
AL514_RS04525	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AL514_RS04530	COG1461	Dihydroxyacetone kinase
AL514_RS04535	COG2376	Dihydroxyacetone kinase
AL514_RS04545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL514_RS04550	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AL514_RS04555	COG0346	lactoylglutathione lyase activity
AL514_RS04565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL514_RS04570	COG0549	Belongs to the carbamate kinase family
AL514_RS04575	COG1288	antiporter activity
AL514_RS04610	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL514_RS04615	COG3246	L-lysine catabolic process to acetate
AL514_RS04620	COG1309	transcriptional regulator
AL514_RS04625	COG1114	Component of the transport system for branched-chain amino acids
AL514_RS04630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL514_RS04635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL514_RS04640	COG1882	Formate acetyltransferase
AL514_RS04650	COG1124	(ABC) transporter
AL514_RS04655	COG0444	Belongs to the ABC transporter superfamily
AL514_RS04665	COG0601	transmembrane transport
AL514_RS04700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL514_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS04715	COG3976	FMN-binding domain protein
AL514_RS04715	COG1053	succinate dehydrogenase
AL514_RS04715	COG0431	NADPH-dependent FMN reductase
AL514_RS04740	COG0523	cobalamin synthesis protein
AL514_RS04770	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
AL514_RS04775	COG0156	8-amino-7-oxononanoate synthase activity
AL514_RS04780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL514_RS04785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL514_RS04835	COG2972	Histidine kinase
AL514_RS04840	COG2207	Transcriptional regulator
AL514_RS04840	COG4753	response regulator
AL514_RS04850	COG1755	Isoprenylcysteine carboxyl methyltransferase
AL514_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS04875	COG0579	oxidoreductase
AL514_RS04880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL514_RS04920	COG0561	phosphatase activity
AL514_RS04925	COG0668	transmembrane transport
AL514_RS04945	COG0640	Transcriptional regulator
AL514_RS04965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL514_RS04970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL514_RS04975	COG0730	response to heat
AL514_RS04980	COG1937	Protein conserved in bacteria
AL514_RS04985	COG2210	Belongs to the sulfur carrier protein TusA family
AL514_RS04990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL514_RS04995	COG1388	LysM domain
AL514_RS05000	COG2217	Heavy metal translocating P-type atpase
AL514_RS05030	COG5002	protein histidine kinase activity
AL514_RS05035	COG0745	RESPONSE REGULATOR receiver
AL514_RS05050	COG1131	(ABC) transporter
AL514_RS05060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL514_RS05085	COG1332	CRISPR-associated RAMP protein, Csm5 family
AL514_RS05090	COG1567	CRISPR-associated RAMP protein, Csm4 family
AL514_RS05095	COG1337	RAMP superfamily
AL514_RS05100	COG1421	Csm2 Type III-A
AL514_RS05105	COG1353	crispr-associated protein
AL514_RS05110	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AL514_RS05165	COG1124	(ABC) transporter
AL514_RS05170	COG4172	Belongs to the ABC transporter superfamily
AL514_RS05205	COG2235	arginine
AL514_RS05215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL514_RS05220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL514_RS05250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL514_RS05255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL514_RS05265	COG2205	protein histidine kinase activity
AL514_RS05270	COG0745	RESPONSE REGULATOR receiver
AL514_RS05295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL514_RS05305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL514_RS05430	COG2030	dehydratase
AL514_RS05435	COG0584	glycerophosphoryl diester phosphodiesterase
AL514_RS05445	COG3425	synthase
AL514_RS05465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL514_RS05470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL514_RS05480	COG4863	YycH protein
AL514_RS05485	COG5002	protein histidine kinase activity
AL514_RS05490	COG0745	RESPONSE REGULATOR receiver
AL514_RS05510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL514_RS05515	COG0305	Participates in initiation and elongation during chromosome replication
AL514_RS05520	COG0359	binds to the 23S rRNA
AL514_RS05525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AL514_RS05535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL514_RS05555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL514_RS05560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL514_RS05565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL514_RS05570	COG0187	DNA topoisomerase II activity
AL514_RS05575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL514_RS05580	COG2501	S4 domain
AL514_RS05585	COG0592	DNA-directed DNA polymerase activity
AL514_RS05590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL514_RS05600	COG0594	ribonuclease P activity
AL514_RS05605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL514_RS05610	COG0445	tRNA wobble uridine modification
AL514_RS05615	COG0357	Ribosomal RNA small subunit methyltransferase G
AL514_RS05620	COG1475	DNA binding
AL514_RS05660	COG1136	(ABC) transporter
AL514_RS05665	COG0577	efflux transmembrane transporter activity
AL514_RS05695	COG0577	efflux transmembrane transporter activity
AL514_RS05700	COG1136	(ABC) transporter
AL514_RS05740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL514_RS05760	COG4555	ABC transporter
AL514_RS05770	COG1476	TRANSCRIPTIONal
AL514_RS05785	COG0183	Belongs to the thiolase family
AL514_RS05795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL514_RS05800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL514_RS05800	COG0646	methionine synthase
AL514_RS05805	COG0626	cystathionine gamma-synthase activity
AL514_RS05810	COG0626	cystathionine gamma-synthase activity
AL514_RS05820	COG1475	DNA binding
AL514_RS05825	COG0668	transmembrane transport
AL514_RS05830	COG4481	Protein conserved in bacteria
AL514_RS05835	COG0012	GTP binding
AL514_RS05850	COG0360	Binds together with S18 to 16S ribosomal RNA
AL514_RS05860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL514_RS05885	COG1280	lysine exporter protein (LysE YggA)
AL514_RS05920	COG3634	alkyl hydroperoxide reductase activity
AL514_RS05925	COG0450	alkyl hydroperoxide reductase
AL514_RS05935	COG0778	Nitroreductase
AL514_RS05940	COG1823	symporter activity
AL514_RS05950	COG5183	chlorophyll binding
AL514_RS05965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL514_RS05970	COG2233	PERMEase
AL514_RS05975	COG0516	GMP reductase activity
AL514_RS05975	COG0517	IMP dehydrogenase activity
AL514_RS05980	COG0519	Catalyzes the synthesis of GMP from XMP
AL514_RS05980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL514_RS06035	COG0523	cobalamin synthesis protein
AL514_RS06055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL514_RS06060	COG3002	Belongs to the UPF0753 family
AL514_RS06070	COG5609	conserved protein (DUF2294)
AL514_RS06085	COG1647	Serine aminopeptidase, S33
AL514_RS06095	COG0733	neurotransmitter:sodium symporter activity
AL514_RS06105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL514_RS06110	COG0626	cystathionine gamma-synthase activity
AL514_RS06115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL514_RS06120	COG2011	ABC-type metal ion transport system permease component
AL514_RS06130	COG1388	LysM domain
AL514_RS06130	COG3942	CHAP domain
AL514_RS06135	COG0438	transferase activity, transferring glycosyl groups
AL514_RS06160	COG0583	DNA-binding transcription factor activity
AL514_RS06165	COG0067	glutamate synthase
AL514_RS06165	COG0070	glutamate synthase
AL514_RS06165	COG0069	glutamate synthase activity
AL514_RS06170	COG0493	'glutamate synthase
AL514_RS06180	COG0583	DNA-binding transcription factor activity
AL514_RS06185	COG2855	membrane
AL514_RS06205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL514_RS06210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL514_RS06215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL514_RS06240	COG1982	Orn Lys Arg decarboxylase major
AL514_RS06245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL514_RS06250	COG3870	Protein conserved in bacteria
AL514_RS06255	COG0470	DNA polymerase III
AL514_RS06260	COG1774	PSP1 C-terminal conserved region
AL514_RS06265	COG4467	Involved in initiation control of chromosome replication
AL514_RS06270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL514_RS06275	COG2827	Endonuclease containing a URI domain
AL514_RS06280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL514_RS06285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL514_RS06285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL514_RS06290	COG0084	hydrolase, TatD family'
AL514_RS06295	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL514_RS06300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL514_RS06305	COG4466	Protein conserved in bacteria
AL514_RS06310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL514_RS06315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL514_RS06320	COG0251	oxidation-reduction process
AL514_RS06325	COG2088	sporulation resulting in formation of a cellular spore
AL514_RS06330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL514_RS06335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL514_RS06340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL514_RS06345	COG0193	aminoacyl-tRNA hydrolase activity
AL514_RS06350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL514_RS06355	COG2244	polysaccharide biosynthetic process
AL514_RS06360	COG3956	TIGRFAM MazG family protein
AL514_RS06365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL514_RS06375	COG1098	S1 RNA binding domain
AL514_RS06380	COG0037	tRNA processing
AL514_RS06385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AL514_RS06390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL514_RS06395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL514_RS06400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL514_RS06405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL514_RS06410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL514_RS06415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL514_RS06420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL514_RS06505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL514_RS06510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AL514_RS06515	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL514_RS06525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL514_RS06530	COG4463	regulation of RNA biosynthetic process
AL514_RS06535	COG3880	PFAM UvrB UvrC protein
AL514_RS06540	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AL514_RS06545	COG0542	response to heat
AL514_RS06550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL514_RS06555	COG4956	integral membrane protein (PIN domain superfamily)
AL514_RS06560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL514_RS06565	COG1045	serine acetyltransferase
AL514_RS06570	COG0215	cysteine-tRNA ligase activity
AL514_RS06575	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AL514_RS06580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL514_RS06585	COG3688	RNA-binding protein containing a PIN domain
AL514_RS06595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL514_RS06600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL514_RS06605	COG0250	Participates in transcription elongation, termination and antitermination
AL514_RS06610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL514_RS06615	COG0081	regulation of translation
AL514_RS06625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL514_RS06630	COG0222	ribosome binding
AL514_RS06635	COG2813	Specifically methylates the guanine in position
AL514_RS06640	COG0085	RNA polymerase activity
AL514_RS06645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL514_RS06655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL514_RS06665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL514_RS06670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL514_RS06675	COG1473	amidohydrolase
AL514_RS06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL514_RS06700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL514_RS06705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL514_RS06710	COG1063	alcohol dehydrogenase
AL514_RS06715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL514_RS06720	COG0546	phosphoglycolate phosphatase activity
AL514_RS06725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL514_RS06735	COG1428	Deoxynucleoside kinase
AL514_RS06740	COG1428	Deoxynucleoside kinase
AL514_RS06755	COG0561	phosphatase activity
AL514_RS06760	COG0431	NADPH-dependent FMN reductase
AL514_RS06780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL514_RS06785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL514_RS06795	COG1469	GTP cyclohydrolase I activity
AL514_RS06800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL514_RS06815	COG0363	glucosamine-6-phosphate deaminase activity
AL514_RS06820	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL514_RS06825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL514_RS06835	COG0318	PFAM AMP-dependent synthetase and ligase
AL514_RS06840	COG0183	Belongs to the thiolase family
AL514_RS06860	COG0351	phosphomethylpyrimidine kinase
AL514_RS06870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL514_RS06880	COG2363	Small membrane protein
AL514_RS06885	COG0531	amino acid
AL514_RS06900	COG3253	May function as heme-dependent peroxidase
AL514_RS06905	COG0280	phosphate acetyltransferase
AL514_RS06910	COG0095	Lipoate-protein ligase
AL514_RS06930	COG4844	belongs to the
AL514_RS06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL514_RS06945	COG0667	Aldo Keto reductase
AL514_RS06950	COG2409	Drug exporters of the RND superfamily
AL514_RS06955	COG2113	Glycine betaine
AL514_RS06975	COG1078	dGTPase activity
AL514_RS06985	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AL514_RS06990	COG1691	(AIR) carboxylase
AL514_RS06995	COG1606	tRNA processing
AL514_RS07000	COG3875	lactate racemase activity
AL514_RS07005	COG1064	alcohol dehydrogenase
AL514_RS07030	COG0018	arginyl-trna synthetase
AL514_RS07035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL514_RS07050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL514_RS07055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL514_RS07060	COG0546	phosphoglycolate phosphatase activity
AL514_RS07080	COG0596	Alpha beta hydrolase
AL514_RS07120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL514_RS07120	COG2111	Na H antiporter
AL514_RS07125	COG2111	Na H antiporter
AL514_RS07130	COG1006	Multisubunit Na H antiporter MnhC subunit
AL514_RS07135	COG0651	ATP synthesis coupled electron transport
AL514_RS07140	COG1863	multisubunit Na H antiporter MnhE subunit
AL514_RS07145	COG2212	antiporter activity
AL514_RS07150	COG1320	monovalent cation:proton antiporter activity
AL514_RS07160	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL514_RS07165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL514_RS07175	COG1321	iron dependent repressor
AL514_RS07185	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL514_RS07190	COG1134	teichoic acid transport
AL514_RS07195	COG1682	transport, permease protein
AL514_RS07200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL514_RS07210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL514_RS07225	COG1132	(ABC) transporter
AL514_RS07230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL514_RS07240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL514_RS07245	COG1120	ATPase activity
AL514_RS07255	COG3949	Membrane
AL514_RS07270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL514_RS07275	COG0745	RESPONSE REGULATOR receiver
AL514_RS07280	COG2205	protein histidine kinase activity
AL514_RS07285	COG1136	(ABC) transporter
AL514_RS07290	COG0577	efflux transmembrane transporter activity
AL514_RS07295	COG1392	Phosphate transport regulator
AL514_RS07300	COG0306	phosphate transporter
AL514_RS07305	COG1388	LysM domain
AL514_RS07305	COG3942	CHAP domain
AL514_RS07325	COG0217	transcriptional regulatory protein
AL514_RS07335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL514_RS07355	COG0583	DNA-binding transcription factor activity
AL514_RS07360	COG2814	Major facilitator Superfamily
AL514_RS07365	COG2839	Protein conserved in bacteria
AL514_RS07390	COG1611	Belongs to the LOG family
AL514_RS07395	COG1671	Belongs to the UPF0178 family
AL514_RS07410	COG1968	undecaprenyl-diphosphatase activity
AL514_RS07415	COG4988	ABC transporter
AL514_RS07420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL514_RS07445	COG0039	L-malate dehydrogenase activity
AL514_RS07450	COG0471	metal ion transport
AL514_RS07455	COG0415	Belongs to the DNA photolyase family
AL514_RS07480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL514_RS07490	COG1349	DNA-binding transcription factor activity
AL514_RS07495	COG1105	Belongs to the carbohydrate kinase PfkB family
AL514_RS07500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL514_RS07500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL514_RS07500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL514_RS07505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL514_RS07510	COG1253	flavin adenine dinucleotide binding
AL514_RS07515	COG0656	L-ascorbic acid biosynthetic process
AL514_RS07525	COG0463	Glycosyl transferase, family 2
AL514_RS07530	COG5002	protein histidine kinase activity
AL514_RS07535	COG0745	RESPONSE REGULATOR receiver
AL514_RS07560	COG0602	queuosine metabolic process
AL514_RS07565	COG0720	synthase
AL514_RS07570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL514_RS07580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL514_RS07595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL514_RS07605	COG1368	sulfuric ester hydrolase activity
AL514_RS07630	COG0488	(ABC) transporter
AL514_RS07635	COG0514	ATP-dependent DNA helicase (RecQ)
AL514_RS07645	COG1174	glycine betaine transport
AL514_RS07650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL514_RS07655	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AL514_RS07660	COG1454	alcohol dehydrogenase
AL514_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
AL514_RS07665	COG1597	lipid kinase activity
AL514_RS07670	COG3104	oligopeptide transport
AL514_RS07675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL514_RS07685	COG1780	Probably involved in ribonucleotide reductase function
AL514_RS07690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL514_RS07695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL514_RS07705	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL514_RS07710	COG4605	iron ion homeostasis
AL514_RS07715	COG4604	ABC transporter, ATP-binding protein
AL514_RS07730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL514_RS07750	COG1929	Belongs to the glycerate kinase type-1 family
AL514_RS07755	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL514_RS07770	COG2199	diguanylate cyclase activity
AL514_RS07775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL514_RS07780	COG1739	Uncharacterized protein family UPF0029
AL514_RS07790	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AL514_RS07795	COG1040	competence protein
AL514_RS07800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL514_RS07805	COG0653	protein targeting
AL514_RS07815	COG1388	LysM domain
AL514_RS07815	COG3942	CHAP domain
AL514_RS07835	COG0556	nucleotide-excision repair
AL514_RS07840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL514_RS07845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL514_RS07850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL514_RS07865	COG0492	ferredoxin-NADP+ reductase activity
AL514_RS07870	COG1660	Displays ATPase and GTPase activities
AL514_RS07875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL514_RS07880	COG1481	regulation of sporulation
AL514_RS07890	COG0740	serine-type endopeptidase activity
AL514_RS07900	COG1090	epimerase
AL514_RS07920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL514_RS07925	COG0126	phosphoglycerate kinase activity
AL514_RS07930	COG0149	triose-phosphate isomerase activity
AL514_RS07935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL514_RS07940	COG0148	phosphopyruvate hydratase activity
AL514_RS07950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL514_RS07955	COG1647	Serine aminopeptidase, S33
AL514_RS07960	COG0557	exoribonuclease II activity
AL514_RS07965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL514_RS08000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL514_RS08040	COG1278	Cold shock
AL514_RS08055	COG4195	phage-related replication protein
AL514_RS08115	COG1764	response to oxidative stress
AL514_RS08120	COG0710	3-dehydroquinate dehydratase activity
AL514_RS08130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL514_RS08135	COG1393	Belongs to the ArsC family
AL514_RS08140	COG0509	glycine decarboxylation via glycine cleavage system
AL514_RS08150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL514_RS08160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL514_RS08165	COG2011	ABC-type metal ion transport system permease component
AL514_RS08170	COG1464	Belongs to the NlpA lipoprotein family
AL514_RS08180	COG3237	CsbD-like
AL514_RS08190	COG0396	ATPase activity
AL514_RS08195	COG0719	Fe-S assembly protein
AL514_RS08200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL514_RS08205	COG0822	iron-sulfur transferase activity
AL514_RS08210	COG0719	Fe-S assembly protein
AL514_RS08225	COG1253	flavin adenine dinucleotide binding
AL514_RS08230	COG1801	Protein of unknown function DUF72
AL514_RS08235	COG0730	response to heat
AL514_RS08240	COG0737	Belongs to the 5'-nucleotidase family
AL514_RS08245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL514_RS08250	COG4470	Protein conserved in bacteria
AL514_RS08260	COG2445	Protein of unknown function DUF86
AL514_RS08265	COG0647	UMP catabolic process
AL514_RS08270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL514_RS08280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL514_RS08285	COG1696	Membrane protein involved in D-alanine export
AL514_RS08290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL514_RS08295	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AL514_RS08300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL514_RS08305	COG4837	Protein of unknown function (DUF1462)
AL514_RS08310	COG1252	NADH dehydrogenase
AL514_RS08315	COG4844	belongs to the
AL514_RS08320	COG0316	Belongs to the HesB IscA family
AL514_RS08325	COG1252	NADH dehydrogenase
AL514_RS08330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL514_RS08335	COG2056	Na+-H+ antiporter family
AL514_RS08340	COG2050	protein possibly involved in aromatic compounds catabolism
AL514_RS08350	COG1320	monovalent cation:proton antiporter activity
AL514_RS08355	COG2212	antiporter activity
AL514_RS08360	COG1863	multisubunit Na H antiporter MnhE subunit
AL514_RS08365	COG0651	ATP synthesis coupled electron transport
AL514_RS08370	COG1006	Multisubunit Na H antiporter MnhC subunit
AL514_RS08375	COG2111	Na H antiporter
AL514_RS08380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL514_RS08380	COG2111	Na H antiporter
AL514_RS08390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL514_RS08395	COG1098	S1 RNA binding domain
AL514_RS08400	COG1902	pentaerythritol trinitrate reductase activity
AL514_RS08415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL514_RS08425	COG0584	glycerophosphoryl diester phosphodiesterase
AL514_RS08430	COG0165	Argininosuccinate lyase
AL514_RS08435	COG0137	argininosuccinate synthase activity
AL514_RS08440	COG0166	Belongs to the GPI family
AL514_RS08445	COG0398	Pfam SNARE associated Golgi protein
AL514_RS08460	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AL514_RS08465	COG1074	ATP-dependent DNA helicase activity
AL514_RS08470	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL514_RS08480	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL514_RS08485	COG0561	phosphatase activity
AL514_RS08500	COG0542	response to heat
AL514_RS08510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL514_RS08525	COG0601	transmembrane transport
AL514_RS08530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL514_RS08535	COG0444	Belongs to the ABC transporter superfamily
AL514_RS08540	COG4608	Belongs to the ABC transporter superfamily
AL514_RS08545	COG4166	transmembrane transport
AL514_RS08550	COG0180	Tryptophanyl-tRNA synthetase
AL514_RS08555	COG1393	Belongs to the ArsC family
AL514_RS08565	COG4862	establishment of competence for transformation
AL514_RS08575	COG1164	Oligoendopeptidase f
AL514_RS08580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL514_RS08585	COG2346	COG2346, Truncated hemoglobins
AL514_RS08600	COG2357	RelA SpoT domain protein
AL514_RS08605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL514_RS08610	COG0564	pseudouridine synthase activity
AL514_RS08615	COG2239	Acts as a magnesium transporter
AL514_RS08620	COG0475	glutathione-regulated potassium exporter activity
AL514_RS08620	COG0569	domain protein
AL514_RS08650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL514_RS08655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL514_RS08665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL514_RS08665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL514_RS08695	COG0628	permease
AL514_RS08700	COG2382	esterase
AL514_RS08705	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL514_RS08710	COG2814	Major facilitator Superfamily
AL514_RS08715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL514_RS08720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL514_RS08730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL514_RS08735	COG0861	Integral membrane protein TerC family
AL514_RS08740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL514_RS08745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL514_RS08750	COG0737	Belongs to the 5'-nucleotidase family
AL514_RS08760	COG4873	Protein conserved in bacteria
AL514_RS08835	COG2314	TM2 domain
AL514_RS08845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL514_RS08855	COG1575	Belongs to the MenA family. Type 1 subfamily
AL514_RS08865	COG1169	isochorismate synthase
AL514_RS08870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL514_RS08880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL514_RS08885	COG0436	Aminotransferase
AL514_RS08890	COG3594	Acyltransferase
AL514_RS08915	COG1316	TRANSCRIPTIONal
AL514_RS08930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL514_RS08935	COG1845	cytochrome c oxidase, subunit III
AL514_RS08940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL514_RS08945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL514_RS08955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL514_RS08960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL514_RS08965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL514_RS08970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL514_RS08975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL514_RS08980	COG0047	phosphoribosylformylglycinamidine synthase activity
AL514_RS08985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL514_RS08990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL514_RS08995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL514_RS09000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL514_RS09005	COG0138	bifunctional purine biosynthesis protein purh
AL514_RS09010	COG0151	Belongs to the GarS family
AL514_RS09015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL514_RS09020	COG4172	Belongs to the ABC transporter superfamily
AL514_RS09030	COG4716	Myosin-crossreactive antigen
AL514_RS09045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL514_RS09055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL514_RS09060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL514_RS09070	COG1271	oxidase subunit
AL514_RS09075	COG1294	oxidase, subunit
AL514_RS09080	COG0569	domain protein
AL514_RS09085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL514_RS09090	COG5503	Protein of unknown function (DUF1447)
AL514_RS09095	COG0242	peptide deformylase activity
AL514_RS09105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL514_RS09110	COG0022	dehydrogenase e1 component
AL514_RS09115	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL514_RS09125	COG4476	Belongs to the UPF0223 family
AL514_RS09135	COG3842	ATPase activity
AL514_RS09140	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL514_RS09165	COG1914	H( )-stimulated, divalent metal cation uptake system
AL514_RS09170	COG4493	Belongs to the UPF0637 family
AL514_RS09175	COG0483	inositol monophosphate 1-phosphatase activity
AL514_RS09185	COG1217	gtp-binding protein TYPA
AL514_RS09205	COG4896	Protein conserved in bacteria
AL514_RS09210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL514_RS09215	COG4838	Belongs to the UPF0358 family
AL514_RS09220	COG0772	Belongs to the SEDS family
AL514_RS09230	COG1612	heme a metabolic process
AL514_RS09235	COG0109	protoheme IX farnesyltransferase activity
AL514_RS09245	COG2340	Cysteine-rich secretory protein family
AL514_RS09250	COG3679	Belongs to the UPF0342 family
AL514_RS09255	COG0584	glycerophosphoryl diester phosphodiesterase
AL514_RS09265	COG4471	UPF0298 protein
AL514_RS09275	COG0742	ribosomal rna small subunit methyltransferase
AL514_RS09280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL514_RS09285	COG1323	Belongs to the UPF0348 family
AL514_RS09300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL514_RS09315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL514_RS09320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL514_RS09325	COG0072	phenylalanine-tRNA ligase activity
AL514_RS09325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL514_RS09330	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL514_RS09335	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL514_RS09345	COG1796	DNA polymerase
AL514_RS09345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL514_RS09350	COG1193	negative regulation of DNA recombination
AL514_RS09355	COG3118	belongs to the thioredoxin family
AL514_RS09360	COG0322	excinuclease ABC activity
AL514_RS09370	COG2009	succinate dehydrogenase
AL514_RS09375	COG1053	succinate dehydrogenase
AL514_RS09380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL514_RS09385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL514_RS09390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL514_RS09430	COG1011	Hydrolase
AL514_RS09435	COG0454	-acetyltransferase
AL514_RS09440	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL514_RS09445	COG2001	Belongs to the MraZ family
AL514_RS09450	COG0275	rRNA processing
AL514_RS09455	COG4839	cell division protein FtsL
AL514_RS09460	COG0768	penicillin binding
AL514_RS09465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL514_RS09470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL514_RS09475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL514_RS09480	COG0849	cell division
AL514_RS09485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL514_RS09490	COG1496	oxidoreductase activity
AL514_RS09495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL514_RS09500	COG1799	cell septum assembly
AL514_RS09505	COG0762	integral membrane protein
AL514_RS09515	COG3599	regulation of cell shape
AL514_RS09520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL514_RS09530	COG3942	CHAP domain
AL514_RS09530	COG1388	LysM domain
AL514_RS09535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL514_RS09540	COG0564	pseudouridine synthase activity
AL514_RS09545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AL514_RS09550	COG2233	PERMEase
AL514_RS09555	COG0540	Belongs to the ATCase OTCase family
AL514_RS09560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL514_RS09565	COG0505	Belongs to the CarA family
AL514_RS09570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL514_RS09575	COG0284	orotidine-5'-phosphate decarboxylase activity
AL514_RS09580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL514_RS09600	COG0194	GDP metabolic process
AL514_RS09605	COG1758	RNA polymerase activity
AL514_RS09610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL514_RS09615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL514_RS09625	COG0242	peptide deformylase activity
AL514_RS09630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL514_RS09635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL514_RS09635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL514_RS09640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL514_RS09645	COG0631	protein serine/threonine phosphatase activity
AL514_RS09655	COG1162	GTPase activity
AL514_RS09660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL514_RS09670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL514_RS09675	COG1302	Protein conserved in bacteria
AL514_RS09680	COG1461	Dihydroxyacetone kinase
AL514_RS09685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL514_RS09690	COG1349	DNA-binding transcription factor activity
AL514_RS09695	COG0416	fatty acid biosynthetic process
AL514_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS09710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL514_RS09715	COG0571	ribonuclease III activity
AL514_RS09720	COG1196	nuclear chromosome segregation
AL514_RS09725	COG0552	protein localization to endoplasmic reticulum
AL514_RS09730	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AL514_RS09735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL514_RS09740	COG0228	four-way junction DNA binding
AL514_RS09745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL514_RS09750	COG0336	Belongs to the RNA methyltransferase TrmD family
AL514_RS09755	COG0335	large ribosomal subunit rRNA binding
AL514_RS09765	COG4485	Bacterial membrane protein, YfhO
AL514_RS09780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL514_RS09785	COG0045	succinate-CoA ligase (ADP-forming) activity
AL514_RS09790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL514_RS09800	COG0758	DNA mediated transformation
AL514_RS09805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL514_RS09810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL514_RS09815	COG4974	Belongs to the 'phage' integrase family
AL514_RS09820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL514_RS09825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL514_RS09830	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL514_RS09835	COG0052	Belongs to the universal ribosomal protein uS2 family
AL514_RS09840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL514_RS09845	COG0528	UMP kinase activity
AL514_RS09850	COG0233	cytoplasmic translational termination
AL514_RS09855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL514_RS09860	COG4589	Belongs to the CDS family
AL514_RS09870	COG0442	prolyl-tRNA aminoacylation
AL514_RS09875	COG2176	DNA-directed DNA polymerase activity
AL514_RS09880	COG0779	Required for maturation of 30S ribosomal subunits
AL514_RS09885	COG0195	Participates in both transcription termination and antitermination
AL514_RS09890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AL514_RS09895	COG1358	cellular component organization or biogenesis
AL514_RS09900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL514_RS09905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL514_RS09910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL514_RS09915	COG0196	riboflavin kinase activity
AL514_RS09920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL514_RS09925	COG1185	polyribonucleotide nucleotidyltransferase activity
AL514_RS09930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL514_RS09935	COG1674	ftsk spoiiie
AL514_RS09940	COG2188	Transcriptional regulator
AL514_RS09945	COG0612	Peptidase, M16
AL514_RS09950	COG0612	Peptidase, M16
AL514_RS09955	COG0300	oxidoreductase activity
AL514_RS09970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL514_RS09980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL514_RS09985	COG1418	mRNA catabolic process
AL514_RS09995	COG1692	metallophosphoesterase
AL514_RS10000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL514_RS10000	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL514_RS10005	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL514_RS10010	COG4195	phage-related replication protein
AL514_RS10020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL514_RS10025	COG4550	Control of competence regulator ComK, YlbF/YmcA
AL514_RS10035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL514_RS10040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL514_RS10045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AL514_RS10050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL514_RS10055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL514_RS10060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL514_RS10070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL514_RS10075	COG1923	regulation of RNA biosynthetic process
AL514_RS10080	COG0386	Belongs to the glutathione peroxidase family
AL514_RS10085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL514_RS10090	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AL514_RS10095	COG0789	Transcriptional regulator
AL514_RS10100	COG0174	glutamine synthetase
AL514_RS10140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL514_RS10145	COG1131	(ABC) transporter
AL514_RS10155	COG4585	Histidine kinase
AL514_RS10160	COG2197	response regulator
AL514_RS10170	COG1525	nuclease
AL514_RS10185	COG0527	aspartate kinase activity
AL514_RS10190	COG0460	homoserine dehydrogenase
AL514_RS10195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL514_RS10200	COG0083	homoserine kinase activity
AL514_RS10215	COG0833	amino acid
AL514_RS10220	COG0753	catalase activity
AL514_RS10230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL514_RS10235	COG0516	GMP reductase activity
AL514_RS10240	COG2340	Cysteine-rich secretory protein family
AL514_RS10250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL514_RS10260	COG4224	UPF0291 protein
AL514_RS10265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL514_RS10275	COG4846	Membrane protein involved in cytochrome C biogenesis
AL514_RS10280	COG0420	3'-5' exonuclease activity
AL514_RS10285	COG0419	ATPase involved in DNA repair
AL514_RS10290	COG1970	mechanosensitive ion channel activity
AL514_RS10295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL514_RS10300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL514_RS10305	COG0824	Thioesterase
AL514_RS10310	COG4841	protein insertion into membrane
AL514_RS10315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL514_RS10320	COG0187	DNA topoisomerase II activity
AL514_RS10325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL514_RS10330	COG1115	amino acid carrier protein
AL514_RS10335	COG3711	transcriptional antiterminator
AL514_RS10340	COG0628	permease
AL514_RS10345	COG0392	lysyltransferase activity
AL514_RS10345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL514_RS10365	COG1942	4-Oxalocrotonate Tautomerase
AL514_RS10370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL514_RS10375	COG0287	Prephenate dehydrogenase
AL514_RS10380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL514_RS10385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL514_RS10385	COG0512	Glutamine amidotransferase of anthranilate synthase
AL514_RS10390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL514_RS10395	COG0134	indole-3-glycerol-phosphate synthase activity
AL514_RS10400	COG0135	phosphoribosylanthranilate isomerase activity
AL514_RS10405	COG0133	tryptophan synthase activity
AL514_RS10410	COG0159	tryptophan synthase activity
AL514_RS10425	COG2348	transferase activity, transferring amino-acyl groups
AL514_RS10430	COG2348	transferase activity, transferring amino-acyl groups
AL514_RS10475	COG0704	Plays a role in the regulation of phosphate uptake
AL514_RS10480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL514_RS10485	COG0581	inorganic phosphate transmembrane transporter activity
AL514_RS10490	COG0573	inorganic phosphate transmembrane transporter activity
AL514_RS10495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL514_RS10500	COG2996	Protein conserved in bacteria
AL514_RS10505	COG0488	(ABC) transporter
AL514_RS10510	COG0527	aspartate kinase activity
AL514_RS10515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL514_RS10520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL514_RS10525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL514_RS10530	COG2171	N-acyltransferase activity
AL514_RS10535	COG1473	amidohydrolase
AL514_RS10555	COG1131	(ABC) transporter
AL514_RS10570	COG1278	Cold shock
AL514_RS10580	COG1254	Belongs to the acylphosphatase family
AL514_RS10590	COG3853	Toxic anion resistance protein (TelA)
AL514_RS10595	COG1114	Component of the transport system for branched-chain amino acids
AL514_RS10600	COG4548	von Willebrand factor, type A
AL514_RS10605	COG0714	Associated with various cellular activities
AL514_RS10625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL514_RS10630	COG0567	Dehydrogenase, E1 component
AL514_RS10640	COG5002	protein histidine kinase activity
AL514_RS10645	COG0745	RESPONSE REGULATOR receiver
AL514_RS10655	COG1349	DNA-binding transcription factor activity
AL514_RS10660	COG0534	Mate efflux family protein
AL514_RS10670	COG0395	ABC-type sugar transport system, permease component
AL514_RS10680	COG4209	transmembrane transport
AL514_RS10685	COG3842	ATPase activity
AL514_RS10690	COG0671	phosphoesterase, PA-phosphatase related
AL514_RS10695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL514_RS10710	COG0793	Belongs to the peptidase S41A family
AL514_RS10715	COG4479	Belongs to the UPF0346 family
AL514_RS10720	COG2190	(PTS) system
AL514_RS10725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL514_RS10750	COG1136	(ABC) transporter
AL514_RS10765	COG1413	lyase activity
AL514_RS10775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL514_RS10790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL514_RS10795	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AL514_RS10805	COG0116	Belongs to the methyltransferase superfamily
AL514_RS10815	COG3599	regulation of cell shape
AL514_RS10820	COG4474	Belongs to the UPF0398 family
AL514_RS10830	COG3331	DNA recombination
AL514_RS10835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL514_RS10835	COG4499	WXG100 protein secretion system (Wss), protein YukC
AL514_RS10845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL514_RS10850	COG3935	DnaD domain protein
AL514_RS10855	COG0017	Asparaginyl-tRNA synthetase
AL514_RS10860	COG1199	ATP-dependent helicase activity
AL514_RS10860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL514_RS10865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL514_RS10865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL514_RS10870	COG0617	tRNA 3'-terminal CCA addition
AL514_RS10875	COG0438	transferase activity, transferring glycosyl groups
AL514_RS10880	COG1694	Mazg nucleotide pyrophosphohydrolase
AL514_RS10885	COG2738	Putative neutral zinc metallopeptidase
AL514_RS10890	COG4347	Protein of unknown function (DUF1405)
AL514_RS10895	COG5582	Belongs to the UPF0302 family
AL514_RS10905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL514_RS10910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL514_RS10915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL514_RS10920	COG0105	UTP biosynthetic process
AL514_RS10930	COG2226	methyltransferase
AL514_RS10945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL514_RS10950	COG1160	GTP binding
AL514_RS10955	COG0539	negative regulation of cytoplasmic translation
AL514_RS10960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL514_RS10965	COG0252	asparaginase activity
AL514_RS10970	COG0492	ferredoxin-NADP+ reductase activity
AL514_RS10975	COG1388	LysM domain
AL514_RS10980	COG0514	ATP-dependent DNA helicase (RecQ)
AL514_RS10990	COG1141	Ferredoxin
AL514_RS11010	COG0745	RESPONSE REGULATOR receiver
AL514_RS11015	COG1187	pseudouridine synthase activity
AL514_RS11020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL514_RS11025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL514_RS11030	COG1547	Domain of unknown function (DUF309)
AL514_RS11035	COG4974	Belongs to the 'phage' integrase family
AL514_RS11040	COG0735	belongs to the Fur family
AL514_RS11045	COG0494	nUDIX hydrolase
AL514_RS11050	COG0667	Aldo Keto reductase
AL514_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
AL514_RS11060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL514_RS11065	COG1234	tRNA 3'-trailer cleavage
AL514_RS11070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL514_RS11085	COG0366	Alpha amylase catalytic
AL514_RS11090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL514_RS11095	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL514_RS11100	COG4129	membrane
AL514_RS11110	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL514_RS11115	COG0022	dehydrogenase e1 component
AL514_RS11120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL514_RS11125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL514_RS11130	COG0497	DNA recombination
AL514_RS11135	COG1438	arginine binding
AL514_RS11145	COG1722	exodeoxyribonuclease VII activity
AL514_RS11150	COG1570	exodeoxyribonuclease VII activity
AL514_RS11155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL514_RS11160	COG1302	Protein conserved in bacteria
AL514_RS11165	COG0439	Biotin carboxylase
AL514_RS11170	COG0511	ligase activity, forming carbon-carbon bonds
AL514_RS11175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL514_RS11180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL514_RS11185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AL514_RS11190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL514_RS11195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL514_RS11200	COG0006	proline dipeptidase activity
AL514_RS11215	COG0095	Lipoate-protein ligase
AL514_RS11220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL514_RS11230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL514_RS11235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL514_RS11240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL514_RS11245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL514_RS11270	COG4537	Required for transformation and DNA binding
AL514_RS11275	COG1459	type II secretion system
AL514_RS11280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL514_RS11290	COG0011	TIGRFAM Protein of
AL514_RS11295	COG1940	carbohydrate kinase activity
AL514_RS11300	COG4483	Protein conserved in bacteria
AL514_RS11310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL514_RS11315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL514_RS11320	COG0768	penicillin binding
AL514_RS11330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL514_RS11335	COG0735	belongs to the Fur family
AL514_RS11340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL514_RS11345	COG1121	(ABC) transporter
AL514_RS11350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL514_RS11355	COG0513	Belongs to the DEAD box helicase family
AL514_RS11360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL514_RS11365	COG2384	SAM-dependent methyltransferase
AL514_RS11370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL514_RS11375	COG0358	DNA primase activity
AL514_RS11380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL514_RS11385	COG0517	IMP dehydrogenase activity
AL514_RS11390	COG0423	glycine-tRNA ligase activity
AL514_RS11395	COG1381	Involved in DNA repair and RecF pathway recombination
AL514_RS11400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL514_RS11410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL514_RS11415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL514_RS11420	COG1702	phosphate starvation-inducible protein PhoH
AL514_RS11430	COG4864	UPF0365 protein
AL514_RS11435	COG1030	water channel activity
AL514_RS11445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL514_RS11450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL514_RS11455	COG2264	protein methyltransferase activity
AL514_RS11460	COG0484	heat shock protein binding
AL514_RS11465	COG0443	Heat shock 70 kDa protein
AL514_RS11470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL514_RS11475	COG1420	regulation of RNA biosynthetic process
AL514_RS11480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL514_RS11485	COG0481	GTPase activity
AL514_RS11490	COG0268	Binds directly to 16S ribosomal RNA
AL514_RS11495	COG1466	dna polymerase III delta subunit
AL514_RS11500	COG0658	competence protein
AL514_RS11500	COG2333	competence protein COMEC
AL514_RS11505	COG2131	deaminase
AL514_RS11515	COG2226	methyltransferase
AL514_RS11520	COG0799	negative regulation of ribosome biogenesis
AL514_RS11525	COG1713	HD superfamily hydrolase involved in NAD metabolism
AL514_RS11530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL514_RS11535	COG1534	Rna-binding protein
AL514_RS11540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL514_RS11545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL514_RS11550	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AL514_RS11555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL514_RS11560	COG1914	H( )-stimulated, divalent metal cation uptake system
AL514_RS11565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL514_RS11570	COG0439	Biotin carboxylase
AL514_RS11575	COG0511	ligase activity, forming carbon-carbon bonds
AL514_RS11580	COG1984	allophanate hydrolase subunit 2
AL514_RS11585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL514_RS11595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL514_RS11600	COG0572	uridine kinase
AL514_RS11605	COG0826	peptidase U32
AL514_RS11610	COG0826	peptidase U32
AL514_RS11620	COG3906	Belongs to the UPF0473 family
AL514_RS11625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL514_RS11630	COG4472	Bacterial protein of unknown function (DUF965)
AL514_RS11635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL514_RS11640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL514_RS11650	COG0482	sulfurtransferase activity
AL514_RS11655	COG1104	cysteine desulfurase activity
AL514_RS11660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL514_RS11670	COG1959	2 iron, 2 sulfur cluster binding
AL514_RS11675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL514_RS11680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL514_RS11690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL514_RS11695	COG0124	histidyl-tRNA synthetase
AL514_RS11700	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL514_RS11705	COG1490	D-aminoacyl-tRNA deacylase activity
AL514_RS11710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL514_RS11720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL514_RS11725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL514_RS11725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL514_RS11730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL514_RS11730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL514_RS11735	COG1862	Preprotein translocase
AL514_RS11740	COG0343	queuine tRNA-ribosyltransferase activity
AL514_RS11745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL514_RS11750	COG2255	four-way junction helicase activity
AL514_RS11755	COG0632	four-way junction helicase activity
AL514_RS11760	COG4492	Belongs to the UPF0735 family
AL514_RS11765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL514_RS11770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL514_RS11775	COG2868	ribosomal protein
AL514_RS11780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL514_RS11810	COG2003	Belongs to the UPF0758 family
AL514_RS11820	COG0285	dihydrofolate synthase activity
AL514_RS11825	COG0525	valine-tRNA ligase activity
AL514_RS11830	COG2818	Glycosylase
AL514_RS11840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL514_RS11845	COG0113	porphobilinogen synthase activity
AL514_RS11855	COG0181	hydroxymethylbilane synthase activity
AL514_RS11865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL514_RS11870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL514_RS11875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL514_RS11880	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL514_RS11890	COG4112	unkown
AL514_RS11895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL514_RS11900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL514_RS11905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL514_RS11910	COG0833	amino acid
AL514_RS11915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL514_RS11920	COG1484	DNA-dependent DNA replication
AL514_RS11925	COG3611	Membrane attachment protein
AL514_RS11930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL514_RS11935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL514_RS11945	COG0237	dephospho-CoA kinase activity
AL514_RS11950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL514_RS11955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL514_RS11955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL514_RS11960	COG5002	protein histidine kinase activity
AL514_RS11965	COG0745	RESPONSE REGULATOR receiver
AL514_RS11970	COG0538	isocitrate dehydrogenase activity
AL514_RS11975	COG0372	Belongs to the citrate synthase family
AL514_RS11980	COG1113	amino acid transport
AL514_RS11985	COG0469	pyruvate kinase activity
AL514_RS11990	COG0205	6-phosphofructokinase activity
AL514_RS11995	COG0825	malonyl-CoA metabolic process
AL514_RS12000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL514_RS12005	COG0281	malic enzyme
AL514_RS12010	COG0587	DNA-directed DNA polymerase activity
AL514_RS12015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL514_RS12020	COG4109	DRTGG domain
AL514_RS12030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL514_RS12035	COG0006	proline dipeptidase activity
AL514_RS12040	COG0686	Belongs to the AlaDH PNT family
AL514_RS12045	COG0589	response to stress
AL514_RS12050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL514_RS12055	COG0827	DNA restriction-modification system
AL514_RS12060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL514_RS12070	COG0301	tRNA thio-modification
AL514_RS12080	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL514_RS12085	COG1956	GAF domain-containing protein
AL514_RS12095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL514_RS12100	COG0584	glycerophosphoryl diester phosphodiesterase
AL514_RS12105	COG1764	response to oxidative stress
AL514_RS12110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL514_RS12115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL514_RS12125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL514_RS12125	COG1263	PTS System
AL514_RS12130	COG0204	Acyl-transferase
AL514_RS12135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL514_RS12140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL514_RS12150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL514_RS12155	COG1609	Transcriptional regulator
AL514_RS12160	COG1605	Chorismate mutase
AL514_RS12160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL514_RS12170	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AL514_RS12175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL514_RS12180	COG1674	ftsk spoiiie
AL514_RS12185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL514_RS12190	COG4848	Belongs to the UPF0354 family
AL514_RS12195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL514_RS12200	COG1363	Peptidase, m42
AL514_RS12210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL514_RS12215	COG0510	thiamine kinase activity
AL514_RS12220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL514_RS12225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL514_RS12235	COG1187	pseudouridine synthase activity
AL514_RS12240	COG2244	polysaccharide biosynthetic process
AL514_RS12245	COG2081	HI0933 family
AL514_RS12260	COG0495	leucyl-tRNA aminoacylation
AL514_RS12265	COG2814	Major facilitator Superfamily
AL514_RS12270	COG1242	4 iron, 4 sulfur cluster binding
AL514_RS12275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AL514_RS12285	COG2267	carboxylic ester hydrolase activity
AL514_RS12290	COG0506	proline dehydrogenase activity
AL514_RS12295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL514_RS12300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL514_RS12300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL514_RS12310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL514_RS12310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL514_RS12320	COG4193	domain, Protein
AL514_RS12320	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL514_RS12320	COG3266	domain, Protein
AL514_RS12350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL514_RS12360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL514_RS12365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL514_RS12375	COG0656	L-ascorbic acid biosynthetic process
AL514_RS12385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL514_RS12390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL514_RS12395	COG1506	peptidase
AL514_RS12400	COG0494	nUDIX hydrolase
AL514_RS12405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL514_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase