locus-tag	class	description
ATM22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATM22_RS00010	COG0592	DNA-directed DNA polymerase activity
ATM22_RS00015	COG2501	S4 domain
ATM22_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ATM22_RS00025	COG0187	DNA topoisomerase II activity
ATM22_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATM22_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ATM22_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ATM22_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATM22_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ATM22_RS00075	COG0359	binds to the 23S rRNA
ATM22_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
ATM22_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ATM22_RS00100	COG0745	RESPONSE REGULATOR receiver
ATM22_RS00105	COG5002	protein histidine kinase activity
ATM22_RS00110	COG4863	YycH protein
ATM22_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ATM22_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ATM22_RS00130	COG1396	sequence-specific DNA binding
ATM22_RS00200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATM22_RS00205	COG0463	Glycosyl transferase, family 2
ATM22_RS00205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS00225	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ATM22_RS00230	COG3421	Type III restriction
ATM22_RS00235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATM22_RS00290	COG0745	RESPONSE REGULATOR receiver
ATM22_RS00295	COG2205	protein histidine kinase activity
ATM22_RS00305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ATM22_RS00310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ATM22_RS00330	COG2801	Transposase and inactivated derivatives
ATM22_RS00340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATM22_RS00345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATM22_RS00355	COG2235	arginine
ATM22_RS00365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ATM22_RS00380	COG0747	negative chemotaxis
ATM22_RS00395	COG4172	Belongs to the ABC transporter superfamily
ATM22_RS00400	COG1124	(ABC) transporter
ATM22_RS00405	COG2217	Heavy metal translocating P-type atpase
ATM22_RS00410	COG1388	LysM domain
ATM22_RS00425	COG1131	(ABC) transporter
ATM22_RS00440	COG0745	RESPONSE REGULATOR receiver
ATM22_RS00445	COG5002	protein histidine kinase activity
ATM22_RS00465	COG1131	(ABC) transporter
ATM22_RS00485	COG0668	transmembrane transport
ATM22_RS00490	COG0561	phosphatase activity
ATM22_RS00515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ATM22_RS00520	COG0579	oxidoreductase
ATM22_RS00530	COG1755	Isoprenylcysteine carboxyl methyltransferase
ATM22_RS00545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ATM22_RS00550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATM22_RS00555	COG0156	8-amino-7-oxononanoate synthase activity
ATM22_RS00560	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ATM22_RS00585	COG0523	cobalamin synthesis protein
ATM22_RS00610	COG0431	NADPH-dependent FMN reductase
ATM22_RS00610	COG3976	FMN-binding domain protein
ATM22_RS00610	COG1053	succinate dehydrogenase
ATM22_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS00655	COG0601	transmembrane transport
ATM22_RS00665	COG0444	Belongs to the ABC transporter superfamily
ATM22_RS00670	COG1124	(ABC) transporter
ATM22_RS00680	COG1131	(ABC) transporter
ATM22_RS00690	COG1882	Formate acetyltransferase
ATM22_RS00695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ATM22_RS00700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATM22_RS00705	COG1114	Component of the transport system for branched-chain amino acids
ATM22_RS00710	COG1309	transcriptional regulator
ATM22_RS00715	COG3246	L-lysine catabolic process to acetate
ATM22_RS00720	COG1250	3-hydroxyacyl-CoA dehydrogenase
ATM22_RS00755	COG1288	antiporter activity
ATM22_RS00760	COG0549	Belongs to the carbamate kinase family
ATM22_RS00765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATM22_RS00775	COG0346	lactoylglutathione lyase activity
ATM22_RS00780	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ATM22_RS00785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ATM22_RS00795	COG2376	Dihydroxyacetone kinase
ATM22_RS00800	COG1461	Dihydroxyacetone kinase
ATM22_RS00805	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ATM22_RS00815	COG2814	Major facilitator Superfamily
ATM22_RS00820	COG0583	DNA-binding transcription factor activity
ATM22_RS00830	COG2814	Major facilitator Superfamily
ATM22_RS00855	COG2814	Major facilitator Superfamily
ATM22_RS00870	COG2962	Rard protein
ATM22_RS00875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ATM22_RS00880	COG0471	metal ion transport
ATM22_RS00885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATM22_RS00890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ATM22_RS00895	COG0022	dehydrogenase e1 component
ATM22_RS00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATM22_RS00920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ATM22_RS00925	COG1054	Belongs to the UPF0176 family
ATM22_RS00930	COG3386	PFAM SMP-30 Gluconolaconase
ATM22_RS00935	COG2353	YceI-like domain
ATM22_RS00940	COG0579	oxidoreductase
ATM22_RS00965	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ATM22_RS00970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ATM22_RS00975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ATM22_RS00980	COG0131	Imidazoleglycerol-phosphate dehydratase
ATM22_RS00985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ATM22_RS00990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ATM22_RS00995	COG0107	imidazoleglycerol-phosphate synthase activity
ATM22_RS01000	COG0140	phosphoribosyl-ATP diphosphatase activity
ATM22_RS01000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ATM22_RS01005	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ATM22_RS01010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ATM22_RS01020	COG0726	polysaccharide deacetylase
ATM22_RS01030	COG1215	transferase activity, transferring glycosyl groups
ATM22_RS01035	COG1309	transcriptional regulator
ATM22_RS01045	COG2814	Major facilitator Superfamily
ATM22_RS01050	COG0737	Belongs to the 5'-nucleotidase family
ATM22_RS01065	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ATM22_RS01070	COG3639	organic phosphonate transmembrane transporter activity
ATM22_RS01090	COG0201	protein transport
ATM22_RS01100	COG1073	alpha beta
ATM22_RS01110	COG0653	protein targeting
ATM22_RS01115	COG0438	transferase activity, transferring glycosyl groups
ATM22_RS01140	COG2814	Major facilitator Superfamily
ATM22_RS01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ATM22_RS01160	COG1764	response to oxidative stress
ATM22_RS01170	COG1705	Flagellar rod assembly protein muramidase FlgJ
ATM22_RS01170	COG3942	CHAP domain
ATM22_RS01180	COG1482	cell wall glycoprotein biosynthetic process
ATM22_RS01185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATM22_RS01185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATM22_RS01185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATM22_RS01190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATM22_RS01190	COG3711	transcriptional antiterminator
ATM22_RS01215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATM22_RS01225	COG1438	arginine binding
ATM22_RS01230	COG2235	arginine
ATM22_RS01235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATM22_RS01245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATM22_RS01255	COG2843	Capsule synthesis protein
ATM22_RS01260	COG3961	Belongs to the TPP enzyme family
ATM22_RS01285	COG4195	phage-related replication protein
ATM22_RS01295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS01300	COG0702	epimerase
ATM22_RS01305	COG1785	Belongs to the alkaline phosphatase family
ATM22_RS01320	COG2205	protein histidine kinase activity
ATM22_RS01325	COG1136	(ABC) transporter
ATM22_RS01340	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATM22_RS01365	COG1846	Transcriptional regulator
ATM22_RS01370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATM22_RS01375	COG0386	Belongs to the glutathione peroxidase family
ATM22_RS01380	COG0175	sulfate reduction
ATM22_RS01385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ATM22_RS01390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATM22_RS01405	COG0730	response to heat
ATM22_RS01410	COG2046	Belongs to the sulfate adenylyltransferase family
ATM22_RS01415	COG0529	Catalyzes the synthesis of activated sulfate
ATM22_RS01425	COG1328	CTP reductase activity
ATM22_RS01430	COG0602	queuosine metabolic process
ATM22_RS01435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ATM22_RS01450	COG1510	regulation of RNA biosynthetic process
ATM22_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS01460	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ATM22_RS01465	COG1473	amidohydrolase
ATM22_RS01480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATM22_RS01485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATM22_RS01485	COG0574	Belongs to the PEP-utilizing enzyme family
ATM22_RS01490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ATM22_RS01495	COG0579	oxidoreductase
ATM22_RS01505	COG3588	fructose-bisphosphate aldolase
ATM22_RS01510	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATM22_RS01540	COG0531	amino acid
ATM22_RS01545	COG0583	DNA-binding transcription factor activity
ATM22_RS01550	COG0039	L-malate dehydrogenase activity
ATM22_RS01555	COG0028	Belongs to the TPP enzyme family
ATM22_RS01560	COG3527	Alpha-acetolactate decarboxylase
ATM22_RS01570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ATM22_RS01575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATM22_RS01580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ATM22_RS01595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ATM22_RS01610	COG0167	dihydroorotate dehydrogenase activity
ATM22_RS01615	COG3001	Fructosamine kinase
ATM22_RS01620	COG1113	amino acid transport
ATM22_RS01635	COG0741	lytic transglycosylase activity
ATM22_RS01645	COG3942	CHAP domain
ATM22_RS01650	COG0436	Aminotransferase
ATM22_RS01660	COG2608	mercury ion transmembrane transporter activity
ATM22_RS01665	COG2217	Heavy metal translocating P-type atpase
ATM22_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS01705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ATM22_RS01710	COG3425	synthase
ATM22_RS01730	COG0583	DNA-binding transcription factor activity
ATM22_RS01735	COG1380	Effector of murein hydrolase LrgA
ATM22_RS01740	COG1346	cytolysis
ATM22_RS01745	COG0028	Belongs to the TPP enzyme family
ATM22_RS01750	COG2190	(PTS) system
ATM22_RS01750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ATM22_RS01750	COG1263	PTS System
ATM22_RS01765	COG1063	alcohol dehydrogenase
ATM22_RS01770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATM22_RS01775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ATM22_RS01790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ATM22_RS01800	COG2843	Capsule synthesis protein
ATM22_RS01815	COG4975	Glucose uptake
ATM22_RS01820	COG1869	D-ribose catabolic process
ATM22_RS01830	COG1070	Carbohydrate kinase
ATM22_RS01845	COG1760	l-serine dehydratase
ATM22_RS01850	COG1760	l-serine dehydratase
ATM22_RS01865	COG3764	Sortase (surface protein transpeptidase)
ATM22_RS01875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATM22_RS01880	COG0778	Nitroreductase
ATM22_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS01895	COG2514	catechol 2,3-dioxygenase activity
ATM22_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS01915	COG3949	Membrane
ATM22_RS01925	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ATM22_RS01930	COG0586	Pfam SNARE associated Golgi protein
ATM22_RS01935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ATM22_RS01940	COG2022	thiamine diphosphate biosynthetic process
ATM22_RS01950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ATM22_RS01960	COG2271	Major facilitator Superfamily
ATM22_RS01975	COG4876	unkown
ATM22_RS01980	COG2357	RelA SpoT domain protein
ATM22_RS01995	COG0789	Transcriptional regulator
ATM22_RS02000	COG2271	Major facilitator Superfamily
ATM22_RS02005	COG1802	Transcriptional regulator
ATM22_RS02015	COG2610	gluconate transmembrane transporter activity
ATM22_RS02020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ATM22_RS02025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATM22_RS02030	COG0438	transferase activity, transferring glycosyl groups
ATM22_RS02035	COG0494	nUDIX hydrolase
ATM22_RS02040	COG0556	nucleotide-excision repair
ATM22_RS02055	COG4221	oxidoreductase activity
ATM22_RS02060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATM22_RS02065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ATM22_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS02085	COG1363	Peptidase, m42
ATM22_RS02095	COG0069	glutamate synthase activity
ATM22_RS02110	COG4619	ABC transporter
ATM22_RS02115	COG0390	transport system, permease component
ATM22_RS02120	COG2814	Major facilitator Superfamily
ATM22_RS02125	COG2272	Belongs to the type-B carboxylesterase lipase family
ATM22_RS02130	COG0531	amino acid
ATM22_RS02140	COG1063	alcohol dehydrogenase
ATM22_RS02160	COG1174	glycine betaine transport
ATM22_RS02165	COG1346	cytolysis
ATM22_RS02170	COG1380	Effector of murein hydrolase LrgA
ATM22_RS02175	COG3279	Response regulator of the LytR AlgR family
ATM22_RS02180	COG3275	phosphorelay sensor kinase activity
ATM22_RS02190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ATM22_RS02195	COG0706	membrane insertase activity
ATM22_RS02205	COG0531	amino acid
ATM22_RS02210	COG1113	amino acid transport
ATM22_RS02235	COG1929	Belongs to the glycerate kinase type-1 family
ATM22_RS02250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ATM22_RS02255	COG0588	phosphoglycerate mutase activity
ATM22_RS02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATM22_RS02270	COG0765	amino acid transport
ATM22_RS02275	COG1126	abc transporter atp-binding protein
ATM22_RS02285	COG2348	transferase activity, transferring amino-acyl groups
ATM22_RS02305	COG2116	formate transmembrane transporter activity
ATM22_RS02310	COG0454	-acetyltransferase
ATM22_RS02320	COG0747	negative chemotaxis
ATM22_RS02330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATM22_RS02335	COG2146	nitrite reductase [NAD(P)H] activity
ATM22_RS02345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ATM22_RS02350	COG1140	nitrate reductase beta subunit
ATM22_RS02360	COG2181	nitrate reductase activity
ATM22_RS02370	COG4585	Histidine kinase
ATM22_RS02375	COG2197	response regulator
ATM22_RS02380	COG2223	nitrite transmembrane transporter activity
ATM22_RS02385	COG1846	Transcriptional regulator
ATM22_RS02390	COG0778	Nitroreductase
ATM22_RS02410	COG3871	stress protein (general stress protein 26)
ATM22_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ATM22_RS02425	COG1263	PTS System
ATM22_RS02460	COG0604	alcohol dehydrogenase
ATM22_RS02465	COG0456	acetyltransferase
ATM22_RS02470	COG0463	Glycosyl transferase, family 2
ATM22_RS02470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS02480	COG0463	Glycosyl transferase, family 2
ATM22_RS02480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS02485	COG1620	l-lactate permease
ATM22_RS02490	COG0438	transferase activity, transferring glycosyl groups
ATM22_RS02495	COG0579	oxidoreductase
ATM22_RS02500	COG3850	Histidine kinase
ATM22_RS02500	COG5002	protein histidine kinase activity
ATM22_RS02505	COG0745	RESPONSE REGULATOR receiver
ATM22_RS02510	COG0577	efflux transmembrane transporter activity
ATM22_RS02515	COG1136	(ABC) transporter
ATM22_RS02530	COG4640	response to antibiotic
ATM22_RS02535	COG2814	Major facilitator Superfamily
ATM22_RS02545	COG1566	PFAM secretion protein HlyD family protein
ATM22_RS02550	COG2814	Major facilitator Superfamily
ATM22_RS02560	COG0657	acetylesterase activity
ATM22_RS02575	COG0598	Magnesium transport protein CorA
ATM22_RS02580	COG1304	FMN binding
ATM22_RS02585	COG0786	glutamate:sodium symporter activity
ATM22_RS02605	COG2094	Belongs to the DNA glycosylase MPG family
ATM22_RS02615	COG1069	ribulokinase activity
ATM22_RS02620	COG2017	converts alpha-aldose to the beta-anomer
ATM22_RS02625	COG2258	MOSC domain
ATM22_RS02630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ATM22_RS02640	COG1266	CAAX protease self-immunity
ATM22_RS02645	COG0010	Belongs to the arginase family
ATM22_RS02650	COG1473	amidohydrolase
ATM22_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS02660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ATM22_RS02680	COG1737	Transcriptional regulator
ATM22_RS02685	COG1263	PTS System
ATM22_RS02685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ATM22_RS02695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATM22_RS02715	COG1113	amino acid transport
ATM22_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ATM22_RS02725	COG1263	PTS System
ATM22_RS02730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ATM22_RS02745	COG1266	CAAX protease self-immunity
ATM22_RS02750	COG2378	regulation of single-species biofilm formation
ATM22_RS02755	COG0483	inositol monophosphate 1-phosphatase activity
ATM22_RS02760	COG1316	TRANSCRIPTIONal
ATM22_RS02785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATM22_RS02790	COG2076	Multidrug Resistance protein
ATM22_RS02795	COG2076	Multidrug Resistance protein
ATM22_RS02800	COG3942	CHAP domain
ATM22_RS02815	COG1757	Na H antiporter
ATM22_RS02820	COG3942	CHAP domain
ATM22_RS02845	COG0829	nickel cation binding
ATM22_RS02850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ATM22_RS02855	COG0830	nickel cation binding
ATM22_RS02860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ATM22_RS02865	COG0804	urea catabolic process
ATM22_RS02870	COG0832	Belongs to the urease beta subunit family
ATM22_RS02875	COG0831	urea catabolic process
ATM22_RS02885	COG1960	acyl-CoA dehydrogenase activity
ATM22_RS02890	COG1957	nucleoside hydrolase
ATM22_RS02895	COG1268	BioY protein
ATM22_RS02910	COG0725	ABC transporter, periplasmic molybdate-binding protein
ATM22_RS02915	COG4149	molybdate abc transporter
ATM22_RS02920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ATM22_RS02925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ATM22_RS02930	COG0521	Mo-molybdopterin cofactor biosynthetic process
ATM22_RS02935	COG0315	cyclic pyranopterin monophosphate synthase activity
ATM22_RS02940	COG0303	'Molybdopterin
ATM22_RS02950	COG0314	molybdopterin synthase activity
ATM22_RS02960	COG0746	molybdenum cofactor guanylyltransferase activity
ATM22_RS02965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATM22_RS02980	COG2814	Major facilitator Superfamily
ATM22_RS02995	COG2348	transferase activity, transferring amino-acyl groups
ATM22_RS03000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATM22_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS03025	COG4975	Glucose uptake
ATM22_RS03030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATM22_RS03030	COG0551	DNA topoisomerase type I activity
ATM22_RS03035	COG2252	PERMEase
ATM22_RS03050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ATM22_RS03055	COG0088	Forms part of the polypeptide exit tunnel
ATM22_RS03060	COG0089	rRNA binding
ATM22_RS03065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ATM22_RS03070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ATM22_RS03075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ATM22_RS03080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ATM22_RS03085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ATM22_RS03095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ATM22_RS03100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ATM22_RS03105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ATM22_RS03110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ATM22_RS03115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ATM22_RS03120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ATM22_RS03125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ATM22_RS03130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ATM22_RS03135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ATM22_RS03140	COG1841	ribosomal large subunit assembly
ATM22_RS03145	COG0200	Binds to the 23S rRNA
ATM22_RS03150	COG0201	protein transport
ATM22_RS03155	COG0563	adenylate kinase activity
ATM22_RS03160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ATM22_RS03165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ATM22_RS03170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ATM22_RS03175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ATM22_RS03180	COG0202	RNA polymerase activity
ATM22_RS03185	COG0203	ribosomal protein L17
ATM22_RS03190	COG1122	ATPase activity
ATM22_RS03195	COG1122	ATPase activity
ATM22_RS03205	COG0101	tRNA pseudouridine synthase activity
ATM22_RS03210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATM22_RS03215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATM22_RS03220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ATM22_RS03225	COG1349	DNA-binding transcription factor activity
ATM22_RS03230	COG0698	ribose 5-phosphate isomerase
ATM22_RS03235	COG0698	ribose 5-phosphate isomerase
ATM22_RS03240	COG1105	Belongs to the carbohydrate kinase PfkB family
ATM22_RS03245	COG3684	Belongs to the aldolase LacD family
ATM22_RS03250	COG1447	Phosphotransferase system cellobiose-specific component IIA
ATM22_RS03255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ATM22_RS03255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ATM22_RS03260	COG2723	6-phospho-beta-galactosidase activity
ATM22_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATM22_RS03275	COG2130	NADP-dependent
ATM22_RS03280	COG0604	alcohol dehydrogenase
ATM22_RS03295	COG1302	Protein conserved in bacteria
ATM22_RS03300	COG4264	IucA IucC family
ATM22_RS03305	COG2814	Major facilitator Superfamily
ATM22_RS03310	COG4264	IucA IucC family
ATM22_RS03315	COG3457	Alanine racemase
ATM22_RS03320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ATM22_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATM22_RS03330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATM22_RS03335	COG3314	Sporulation integral membrane protein YlbJ
ATM22_RS03340	COG2329	Antibiotic biosynthesis monooxygenase
ATM22_RS03350	COG1988	membrane-bound metal-dependent
ATM22_RS03355	COG4284	Utp--glucose-1-phosphate uridylyltransferase
ATM22_RS03375	COG2814	Major facilitator Superfamily
ATM22_RS03380	COG0489	protein tyrosine kinase activity
ATM22_RS03430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ATM22_RS03440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATM22_RS03445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ATM22_RS03450	COG0561	phosphatase activity
ATM22_RS03470	COG0640	Transcriptional regulator
ATM22_RS03475	COG0702	epimerase
ATM22_RS03480	COG1482	cell wall glycoprotein biosynthetic process
ATM22_RS03500	COG0783	Belongs to the Dps family
ATM22_RS03505	COG0813	purine-nucleoside phosphorylase activity
ATM22_RS03510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ATM22_RS03515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ATM22_RS03520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ATM22_RS03530	COG1854	S-ribosylhomocysteine lyase activity
ATM22_RS03550	COG5146	pantothenate kinase activity
ATM22_RS03560	COG3343	RNA polymerase activity
ATM22_RS03565	COG0504	CTP synthase activity
ATM22_RS03575	COG0191	fructose-bisphosphate aldolase activity
ATM22_RS03580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATM22_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS03590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ATM22_RS03595	COG0254	rRNA binding
ATM22_RS03600	COG1435	thymidine kinase activity
ATM22_RS03605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ATM22_RS03610	COG2890	protein-(glutamine-N5) methyltransferase activity
ATM22_RS03615	COG0009	L-threonylcarbamoyladenylate synthase
ATM22_RS03620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATM22_RS03625	COG4475	Protein of unknown function (DUF436)
ATM22_RS03630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATM22_RS03635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ATM22_RS03640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ATM22_RS03650	COG0356	it plays a direct role in the translocation of protons across the membrane
ATM22_RS03660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ATM22_RS03665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATM22_RS03670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ATM22_RS03675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ATM22_RS03680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ATM22_RS03685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ATM22_RS03695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATM22_RS03700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ATM22_RS03710	COG0629	single-stranded DNA binding
ATM22_RS03715	COG1388	LysM domain
ATM22_RS03720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ATM22_RS03730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ATM22_RS03735	COG0352	thiamine-phosphate diphosphorylase activity
ATM22_RS03740	COG0706	membrane insertase activity
ATM22_RS03745	COG1418	mRNA catabolic process
ATM22_RS03750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATM22_RS03755	COG1937	Protein conserved in bacteria
ATM22_RS03770	COG0772	Belongs to the SEDS family
ATM22_RS03775	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATM22_RS03780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ATM22_RS03785	COG0513	Belongs to the DEAD box helicase family
ATM22_RS03795	COG3428	Bacterial PH domain
ATM22_RS03800	COG3402	PFAM membrane-flanked domain
ATM22_RS03805	COG0736	holo-[acyl-carrier-protein] synthase activity
ATM22_RS03810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ATM22_RS03820	COG2337	Toxic component of a toxin-antitoxin (TA) module
ATM22_RS03825	COG2208	phosphoserine phosphatase activity
ATM22_RS03840	COG1191	sigma factor activity
ATM22_RS03845	COG2183	response to ionizing radiation
ATM22_RS03850	COG3091	SprT-like family
ATM22_RS03880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATM22_RS03885	COG0066	3-isopropylmalate dehydratase activity
ATM22_RS03895	COG0473	3-isopropylmalate dehydrogenase activity
ATM22_RS03905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ATM22_RS03915	COG0028	Belongs to the TPP enzyme family
ATM22_RS03920	COG0129	dihydroxy-acid dehydratase activity
ATM22_RS03925	COG0802	atpase or kinase
ATM22_RS03930	COG1214	PFAM Peptidase M22, glycoprotease
ATM22_RS03935	COG0456	acetyltransferase
ATM22_RS03940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ATM22_RS03945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ATM22_RS03950	COG0488	(ABC) transporter
ATM22_RS03955	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ATM22_RS03965	COG2391	methyltransferase activity
ATM22_RS03970	COG0425	Belongs to the sulfur carrier protein TusA family
ATM22_RS03975	COG0004	ammonium transporteR
ATM22_RS03980	COG1609	Transcriptional regulator
ATM22_RS03985	COG1621	beta-fructofuranosidase activity
ATM22_RS03990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATM22_RS03995	COG3279	Response regulator of the LytR AlgR family
ATM22_RS04000	COG3290	protein histidine kinase activity
ATM22_RS04035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ATM22_RS04040	COG0459	protein refolding
ATM22_RS04045	COG0582	viral genome integration into host DNA
ATM22_RS04190	COG1725	Transcriptional regulator
ATM22_RS04195	COG1131	(ABC) transporter
ATM22_RS04205	COG1131	(ABC) transporter
ATM22_RS04255	COG4974	Belongs to the 'phage' integrase family
ATM22_RS04280	COG3682	Transcriptional regulator
ATM22_RS04285	COG2706	6-phosphogluconolactonase activity
ATM22_RS04290	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS04295	COG1227	inorganic diphosphatase activity
ATM22_RS04300	COG1335	isochorismatase
ATM22_RS04310	COG0077	Prephenate dehydratase
ATM22_RS04320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ATM22_RS04325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ATM22_RS04330	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ATM22_RS04340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ATM22_RS04345	COG4496	protein, YerC YecD
ATM22_RS04350	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ATM22_RS04355	COG0210	DNA helicase
ATM22_RS04360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ATM22_RS04365	COG4851	CamS sex pheromone cAM373 precursor
ATM22_RS04370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ATM22_RS04375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATM22_RS04380	COG0154	amidase activity
ATM22_RS04385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATM22_RS04390	COG1597	lipid kinase activity
ATM22_RS04395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATM22_RS04405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATM22_RS04415	COG1528	Iron-storage protein
ATM22_RS04435	COG4129	membrane
ATM22_RS04440	COG0024	Methionine aminopeptidase
ATM22_RS04455	COG4585	Histidine kinase
ATM22_RS04460	COG2197	response regulator
ATM22_RS04465	COG1295	ribonuclease BN
ATM22_RS04475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATM22_RS04480	COG4840	Belongs to the UPF0435 family
ATM22_RS04485	COG2309	aminopeptidase activity
ATM22_RS04490	COG1607	acyl-coa hydrolase
ATM22_RS04495	COG0535	radical SAM domain protein
ATM22_RS04510	COG0693	protein deglycase activity
ATM22_RS04515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ATM22_RS04520	COG2137	regulation of response to DNA damage stimulus
ATM22_RS04530	COG1388	LysM domain
ATM22_RS04530	COG1134	teichoic acid transport
ATM22_RS04540	COG1988	membrane-bound metal-dependent
ATM22_RS04550	COG3557	Belongs to the UPF0374 family
ATM22_RS04560	COG4129	membrane
ATM22_RS04565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATM22_RS04570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ATM22_RS04575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATM22_RS04580	COG0735	belongs to the Fur family
ATM22_RS04750	COG0765	amino acid transport
ATM22_RS04755	COG1126	abc transporter atp-binding protein
ATM22_RS04765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ATM22_RS04790	COG0114	fumarate hydratase activity
ATM22_RS04795	COG0564	pseudouridine synthase activity
ATM22_RS04800	COG2203	Gaf domain
ATM22_RS04800	COG4585	Histidine kinase
ATM22_RS04805	COG2197	response regulator
ATM22_RS04815	COG4399	Belongs to the UPF0754 family
ATM22_RS04820	COG3679	Belongs to the UPF0342 family
ATM22_RS04825	COG0420	3'-5' exonuclease activity
ATM22_RS04835	COG3481	metal-dependent phosphohydrolase, HD sub domain
ATM22_RS04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATM22_RS04860	COG0537	adenosine 5'-monophosphoramidase activity
ATM22_RS04865	COG1131	(ABC) transporter
ATM22_RS04870	COG4473	ABC transporter
ATM22_RS04880	COG2329	Antibiotic biosynthesis monooxygenase
ATM22_RS04885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ATM22_RS04890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ATM22_RS04895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ATM22_RS04970	COG0318	PFAM AMP-dependent synthetase and ligase
ATM22_RS04980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ATM22_RS04985	COG0494	nUDIX hydrolase
ATM22_RS04990	COG1506	peptidase
ATM22_RS04995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ATM22_RS05000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ATM22_RS05010	COG0656	L-ascorbic acid biosynthetic process
ATM22_RS05020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATM22_RS05025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATM22_RS05035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ATM22_RS05060	COG3266	domain, Protein
ATM22_RS05060	COG5632	N-Acetylmuramoyl-L-alanine amidase
ATM22_RS05060	COG4193	domain, Protein
ATM22_RS05070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATM22_RS05070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATM22_RS05080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATM22_RS05080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ATM22_RS05085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ATM22_RS05090	COG0506	proline dehydrogenase activity
ATM22_RS05095	COG2267	carboxylic ester hydrolase activity
ATM22_RS05105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ATM22_RS05110	COG1242	4 iron, 4 sulfur cluster binding
ATM22_RS05115	COG2814	Major facilitator Superfamily
ATM22_RS05120	COG0495	leucyl-tRNA aminoacylation
ATM22_RS05135	COG2081	HI0933 family
ATM22_RS05140	COG2244	polysaccharide biosynthetic process
ATM22_RS05145	COG1187	pseudouridine synthase activity
ATM22_RS05155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATM22_RS05160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ATM22_RS05165	COG0510	thiamine kinase activity
ATM22_RS05170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATM22_RS05180	COG1363	Peptidase, m42
ATM22_RS05185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATM22_RS05190	COG4848	Belongs to the UPF0354 family
ATM22_RS05195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATM22_RS05200	COG1674	ftsk spoiiie
ATM22_RS05205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ATM22_RS05210	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ATM22_RS05220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ATM22_RS05220	COG1605	Chorismate mutase
ATM22_RS05225	COG1609	Transcriptional regulator
ATM22_RS05230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ATM22_RS05240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ATM22_RS05245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATM22_RS05250	COG0204	Acyl-transferase
ATM22_RS05255	COG1263	PTS System
ATM22_RS05255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ATM22_RS05265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ATM22_RS05275	COG1764	response to oxidative stress
ATM22_RS05280	COG0584	glycerophosphoryl diester phosphodiesterase
ATM22_RS05285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ATM22_RS05290	COG1956	GAF domain-containing protein
ATM22_RS05295	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ATM22_RS05305	COG0301	tRNA thio-modification
ATM22_RS05315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ATM22_RS05320	COG0827	DNA restriction-modification system
ATM22_RS05325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ATM22_RS05335	COG0589	response to stress
ATM22_RS05340	COG0686	Belongs to the AlaDH PNT family
ATM22_RS05345	COG0006	proline dipeptidase activity
ATM22_RS05350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ATM22_RS05360	COG4109	DRTGG domain
ATM22_RS05365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ATM22_RS05370	COG0587	DNA-directed DNA polymerase activity
ATM22_RS05375	COG0281	malic enzyme
ATM22_RS05380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ATM22_RS05385	COG0825	malonyl-CoA metabolic process
ATM22_RS05390	COG0205	6-phosphofructokinase activity
ATM22_RS05395	COG0469	pyruvate kinase activity
ATM22_RS05400	COG1113	amino acid transport
ATM22_RS05405	COG0372	Belongs to the citrate synthase family
ATM22_RS05410	COG0538	isocitrate dehydrogenase activity
ATM22_RS05415	COG0745	RESPONSE REGULATOR receiver
ATM22_RS05420	COG5002	protein histidine kinase activity
ATM22_RS05425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATM22_RS05425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATM22_RS05430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATM22_RS05435	COG0237	dephospho-CoA kinase activity
ATM22_RS05445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ATM22_RS05450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ATM22_RS05455	COG3611	Membrane attachment protein
ATM22_RS05460	COG1484	DNA-dependent DNA replication
ATM22_RS05465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ATM22_RS05470	COG0833	amino acid
ATM22_RS05475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ATM22_RS05480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ATM22_RS05485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ATM22_RS05490	COG4112	unkown
ATM22_RS05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
ATM22_RS05505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ATM22_RS05510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ATM22_RS05515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ATM22_RS05525	COG0181	hydroxymethylbilane synthase activity
ATM22_RS05535	COG0113	porphobilinogen synthase activity
ATM22_RS05540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATM22_RS05550	COG2818	Glycosylase
ATM22_RS05555	COG0525	valine-tRNA ligase activity
ATM22_RS05560	COG0285	dihydrofolate synthase activity
ATM22_RS05570	COG2003	Belongs to the UPF0758 family
ATM22_RS05600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ATM22_RS05605	COG2868	ribosomal protein
ATM22_RS05610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ATM22_RS05615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ATM22_RS05620	COG4492	Belongs to the UPF0735 family
ATM22_RS05625	COG0632	four-way junction helicase activity
ATM22_RS05630	COG2255	four-way junction helicase activity
ATM22_RS05635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ATM22_RS05640	COG0343	queuine tRNA-ribosyltransferase activity
ATM22_RS05645	COG1862	Preprotein translocase
ATM22_RS05650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATM22_RS05650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATM22_RS05660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ATM22_RS05660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ATM22_RS05665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATM22_RS05670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATM22_RS05675	COG1490	D-aminoacyl-tRNA deacylase activity
ATM22_RS05680	COG0860	N-Acetylmuramoyl-L-alanine amidase
ATM22_RS05685	COG0124	histidyl-tRNA synthetase
ATM22_RS05690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ATM22_RS05700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ATM22_RS05710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ATM22_RS05715	COG1959	2 iron, 2 sulfur cluster binding
ATM22_RS05725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATM22_RS05730	COG1104	cysteine desulfurase activity
ATM22_RS05735	COG0482	sulfurtransferase activity
ATM22_RS05745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ATM22_RS05750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ATM22_RS05755	COG4472	Bacterial protein of unknown function (DUF965)
ATM22_RS05760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ATM22_RS05765	COG3906	Belongs to the UPF0473 family
ATM22_RS05775	COG0826	peptidase U32
ATM22_RS05780	COG0826	peptidase U32
ATM22_RS05785	COG0572	uridine kinase
ATM22_RS05790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ATM22_RS05800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ATM22_RS05805	COG1984	allophanate hydrolase subunit 2
ATM22_RS05810	COG0511	ligase activity, forming carbon-carbon bonds
ATM22_RS05815	COG0439	Biotin carboxylase
ATM22_RS05820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ATM22_RS05825	COG1914	H( )-stimulated, divalent metal cation uptake system
ATM22_RS05830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ATM22_RS05835	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ATM22_RS05840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ATM22_RS05845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATM22_RS05850	COG1534	Rna-binding protein
ATM22_RS05855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ATM22_RS05860	COG1713	HD superfamily hydrolase involved in NAD metabolism
ATM22_RS05865	COG0799	negative regulation of ribosome biogenesis
ATM22_RS05870	COG2226	methyltransferase
ATM22_RS05880	COG2131	deaminase
ATM22_RS05885	COG2333	competence protein COMEC
ATM22_RS05885	COG0658	competence protein
ATM22_RS05890	COG1466	dna polymerase III delta subunit
ATM22_RS05895	COG0268	Binds directly to 16S ribosomal RNA
ATM22_RS05900	COG0481	GTPase activity
ATM22_RS05905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ATM22_RS05910	COG1420	regulation of RNA biosynthetic process
ATM22_RS05915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ATM22_RS05920	COG0443	Heat shock 70 kDa protein
ATM22_RS05925	COG0484	heat shock protein binding
ATM22_RS05930	COG2264	protein methyltransferase activity
ATM22_RS05935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ATM22_RS05940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATM22_RS05950	COG1030	water channel activity
ATM22_RS05955	COG4864	UPF0365 protein
ATM22_RS05965	COG1702	phosphate starvation-inducible protein PhoH
ATM22_RS05970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ATM22_RS05975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ATM22_RS05980	COG0295	cytidine deaminase activity
ATM22_RS05985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ATM22_RS05990	COG1381	Involved in DNA repair and RecF pathway recombination
ATM22_RS05995	COG0423	glycine-tRNA ligase activity
ATM22_RS06000	COG0517	IMP dehydrogenase activity
ATM22_RS06005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ATM22_RS06010	COG0358	DNA primase activity
ATM22_RS06015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ATM22_RS06020	COG2384	SAM-dependent methyltransferase
ATM22_RS06025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ATM22_RS06030	COG0513	Belongs to the DEAD box helicase family
ATM22_RS06035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ATM22_RS06040	COG1121	(ABC) transporter
ATM22_RS06045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATM22_RS06050	COG0735	belongs to the Fur family
ATM22_RS06055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ATM22_RS06060	COG0768	penicillin binding
ATM22_RS06065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATM22_RS06070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ATM22_RS06080	COG4483	Protein conserved in bacteria
ATM22_RS06085	COG1940	carbohydrate kinase activity
ATM22_RS06090	COG0011	TIGRFAM Protein of
ATM22_RS06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATM22_RS06100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ATM22_RS06105	COG1459	type II secretion system
ATM22_RS06110	COG4537	Required for transformation and DNA binding
ATM22_RS06130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ATM22_RS06135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ATM22_RS06140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATM22_RS06145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATM22_RS06155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATM22_RS06160	COG0095	Lipoate-protein ligase
ATM22_RS06175	COG0006	proline dipeptidase activity
ATM22_RS06180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATM22_RS06185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ATM22_RS06190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ATM22_RS06195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATM22_RS06200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATM22_RS06205	COG0511	ligase activity, forming carbon-carbon bonds
ATM22_RS06210	COG0439	Biotin carboxylase
ATM22_RS06215	COG1302	Protein conserved in bacteria
ATM22_RS06220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATM22_RS06225	COG1570	exodeoxyribonuclease VII activity
ATM22_RS06230	COG1722	exodeoxyribonuclease VII activity
ATM22_RS06240	COG1438	arginine binding
ATM22_RS06245	COG0497	DNA recombination
ATM22_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATM22_RS06255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ATM22_RS06260	COG0022	dehydrogenase e1 component
ATM22_RS06265	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATM22_RS06275	COG4129	membrane
ATM22_RS06285	COG2195	Cleaves the N-terminal amino acid of tripeptides
ATM22_RS06290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ATM22_RS06295	COG0366	Alpha amylase catalytic
ATM22_RS06305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ATM22_RS06310	COG1234	tRNA 3'-trailer cleavage
ATM22_RS06315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ATM22_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS06325	COG0667	Aldo Keto reductase
ATM22_RS06330	COG0494	nUDIX hydrolase
ATM22_RS06335	COG0735	belongs to the Fur family
ATM22_RS06340	COG4974	Belongs to the 'phage' integrase family
ATM22_RS06345	COG1547	Domain of unknown function (DUF309)
ATM22_RS06350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ATM22_RS06355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ATM22_RS06360	COG1187	pseudouridine synthase activity
ATM22_RS06365	COG0745	RESPONSE REGULATOR receiver
ATM22_RS06380	COG1141	Ferredoxin
ATM22_RS06390	COG0514	ATP-dependent DNA helicase (RecQ)
ATM22_RS06395	COG1388	LysM domain
ATM22_RS06400	COG0492	ferredoxin-NADP+ reductase activity
ATM22_RS06405	COG0252	asparaginase activity
ATM22_RS06410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ATM22_RS06415	COG0539	negative regulation of cytoplasmic translation
ATM22_RS06420	COG1160	GTP binding
ATM22_RS06425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ATM22_RS06440	COG2226	methyltransferase
ATM22_RS06450	COG0105	UTP biosynthetic process
ATM22_RS06455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ATM22_RS06460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ATM22_RS06465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ATM22_RS06475	COG5582	Belongs to the UPF0302 family
ATM22_RS06480	COG4347	Protein of unknown function (DUF1405)
ATM22_RS06485	COG2738	Putative neutral zinc metallopeptidase
ATM22_RS06490	COG1694	Mazg nucleotide pyrophosphohydrolase
ATM22_RS06495	COG0438	transferase activity, transferring glycosyl groups
ATM22_RS06500	COG0617	tRNA 3'-terminal CCA addition
ATM22_RS06505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ATM22_RS06505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ATM22_RS06510	COG1199	ATP-dependent helicase activity
ATM22_RS06510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ATM22_RS06515	COG0017	Asparaginyl-tRNA synthetase
ATM22_RS06520	COG3935	DnaD domain protein
ATM22_RS06525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ATM22_RS06535	COG4499	WXG100 protein secretion system (Wss), protein YukC
ATM22_RS06535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ATM22_RS06540	COG3331	DNA recombination
ATM22_RS06550	COG4474	Belongs to the UPF0398 family
ATM22_RS06555	COG3599	regulation of cell shape
ATM22_RS06565	COG0116	Belongs to the methyltransferase superfamily
ATM22_RS06575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ATM22_RS06580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATM22_RS06585	COG4372	Transposase
ATM22_RS06585	COG1511	domain protein
ATM22_RS06585	COG1196	nuclear chromosome segregation
ATM22_RS06595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ATM22_RS06605	COG1413	lyase activity
ATM22_RS06620	COG1136	(ABC) transporter
ATM22_RS06645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATM22_RS06650	COG2190	(PTS) system
ATM22_RS06655	COG4479	Belongs to the UPF0346 family
ATM22_RS06660	COG0793	Belongs to the peptidase S41A family
ATM22_RS06670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATM22_RS06675	COG0671	phosphoesterase, PA-phosphatase related
ATM22_RS06680	COG3842	ATPase activity
ATM22_RS06685	COG4209	transmembrane transport
ATM22_RS06695	COG0395	ABC-type sugar transport system, permease component
ATM22_RS06705	COG0534	Mate efflux family protein
ATM22_RS06710	COG1349	DNA-binding transcription factor activity
ATM22_RS06715	COG0745	RESPONSE REGULATOR receiver
ATM22_RS06720	COG5002	protein histidine kinase activity
ATM22_RS06725	COG0567	Dehydrogenase, E1 component
ATM22_RS06730	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATM22_RS06740	COG1131	(ABC) transporter
ATM22_RS06760	COG0714	Associated with various cellular activities
ATM22_RS06765	COG4548	von Willebrand factor, type A
ATM22_RS06770	COG1114	Component of the transport system for branched-chain amino acids
ATM22_RS06775	COG3853	Toxic anion resistance protein (TelA)
ATM22_RS06785	COG1254	Belongs to the acylphosphatase family
ATM22_RS06795	COG1278	Cold shock
ATM22_RS06810	COG1131	(ABC) transporter
ATM22_RS06830	COG1473	amidohydrolase
ATM22_RS06835	COG2171	N-acyltransferase activity
ATM22_RS06840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ATM22_RS06845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATM22_RS06850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATM22_RS06855	COG0527	aspartate kinase activity
ATM22_RS06860	COG0488	(ABC) transporter
ATM22_RS06865	COG2996	Protein conserved in bacteria
ATM22_RS06870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATM22_RS06875	COG0573	inorganic phosphate transmembrane transporter activity
ATM22_RS06880	COG0581	inorganic phosphate transmembrane transporter activity
ATM22_RS06885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ATM22_RS06890	COG0704	Plays a role in the regulation of phosphate uptake
ATM22_RS06895	COG1164	Oligoendopeptidase f
ATM22_RS06925	COG4607	ABC-type enterochelin transport system periplasmic component
ATM22_RS06935	COG2348	transferase activity, transferring amino-acyl groups
ATM22_RS06940	COG2348	transferase activity, transferring amino-acyl groups
ATM22_RS06950	COG0159	tryptophan synthase activity
ATM22_RS06955	COG0133	tryptophan synthase activity
ATM22_RS06960	COG0135	phosphoribosylanthranilate isomerase activity
ATM22_RS06965	COG0134	indole-3-glycerol-phosphate synthase activity
ATM22_RS06970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATM22_RS06975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATM22_RS06975	COG0512	Glutamine amidotransferase of anthranilate synthase
ATM22_RS06980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ATM22_RS06985	COG0287	Prephenate dehydrogenase
ATM22_RS06990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATM22_RS06995	COG1942	4-Oxalocrotonate Tautomerase
ATM22_RS07010	COG0392	lysyltransferase activity
ATM22_RS07010	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ATM22_RS07015	COG0628	permease
ATM22_RS07020	COG3711	transcriptional antiterminator
ATM22_RS07025	COG1115	amino acid carrier protein
ATM22_RS07030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ATM22_RS07035	COG0187	DNA topoisomerase II activity
ATM22_RS07040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ATM22_RS07045	COG4841	protein insertion into membrane
ATM22_RS07050	COG0824	Thioesterase
ATM22_RS07055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ATM22_RS07060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ATM22_RS07065	COG1970	mechanosensitive ion channel activity
ATM22_RS07070	COG0419	ATPase involved in DNA repair
ATM22_RS07075	COG0420	3'-5' exonuclease activity
ATM22_RS07080	COG4846	Membrane protein involved in cytochrome C biogenesis
ATM22_RS07090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ATM22_RS07095	COG4224	UPF0291 protein
ATM22_RS07105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ATM22_RS07110	COG2340	Cysteine-rich secretory protein family
ATM22_RS07115	COG0516	GMP reductase activity
ATM22_RS07120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ATM22_RS07135	COG0833	amino acid
ATM22_RS07150	COG0083	homoserine kinase activity
ATM22_RS07155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ATM22_RS07160	COG0460	homoserine dehydrogenase
ATM22_RS07165	COG0527	aspartate kinase activity
ATM22_RS07180	COG1525	nuclease
ATM22_RS07190	COG2197	response regulator
ATM22_RS07195	COG4585	Histidine kinase
ATM22_RS07205	COG1131	(ABC) transporter
ATM22_RS07210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATM22_RS07255	COG1192	Involved in chromosome partitioning
ATM22_RS07275	COG4824	toxin secretion phage lysis holin
ATM22_RS07360	COG0740	serine-type endopeptidase activity
ATM22_RS07470	COG0174	glutamine synthetase
ATM22_RS07475	COG0789	Transcriptional regulator
ATM22_RS07480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ATM22_RS07485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ATM22_RS07490	COG0386	Belongs to the glutathione peroxidase family
ATM22_RS07495	COG1923	regulation of RNA biosynthetic process
ATM22_RS07500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ATM22_RS07510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ATM22_RS07515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ATM22_RS07520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ATM22_RS07525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ATM22_RS07530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ATM22_RS07535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ATM22_RS07545	COG4550	Control of competence regulator ComK, YlbF/YmcA
ATM22_RS07550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATM22_RS07560	COG4195	phage-related replication protein
ATM22_RS07565	COG1013	pyruvate-flavodoxin oxidoreductase activity
ATM22_RS07570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ATM22_RS07570	COG0674	pyruvate-flavodoxin oxidoreductase activity
ATM22_RS07575	COG1692	metallophosphoesterase
ATM22_RS07585	COG1418	mRNA catabolic process
ATM22_RS07590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ATM22_RS07595	COG1058	Belongs to the CinA family
ATM22_RS07595	COG1546	Belongs to the CinA family
ATM22_RS07600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ATM22_RS07615	COG0300	oxidoreductase activity
ATM22_RS07620	COG0612	Peptidase, M16
ATM22_RS07625	COG0612	Peptidase, M16
ATM22_RS07630	COG2188	Transcriptional regulator
ATM22_RS07635	COG1674	ftsk spoiiie
ATM22_RS07640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ATM22_RS07645	COG1185	polyribonucleotide nucleotidyltransferase activity
ATM22_RS07650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ATM22_RS07655	COG0196	riboflavin kinase activity
ATM22_RS07660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ATM22_RS07665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ATM22_RS07670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ATM22_RS07675	COG1358	cellular component organization or biogenesis
ATM22_RS07680	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ATM22_RS07685	COG0195	Participates in both transcription termination and antitermination
ATM22_RS07690	COG0779	Required for maturation of 30S ribosomal subunits
ATM22_RS07695	COG2176	DNA-directed DNA polymerase activity
ATM22_RS07700	COG0442	prolyl-tRNA aminoacylation
ATM22_RS07710	COG4589	Belongs to the CDS family
ATM22_RS07715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATM22_RS07720	COG0233	cytoplasmic translational termination
ATM22_RS07725	COG0528	UMP kinase activity
ATM22_RS07730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ATM22_RS07735	COG0052	Belongs to the universal ribosomal protein uS2 family
ATM22_RS07740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ATM22_RS07745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ATM22_RS07750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ATM22_RS07755	COG4974	Belongs to the 'phage' integrase family
ATM22_RS07760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ATM22_RS07765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATM22_RS07770	COG0758	DNA mediated transformation
ATM22_RS07775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ATM22_RS07780	COG0045	succinate-CoA ligase (ADP-forming) activity
ATM22_RS07785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATM22_RS07795	COG4485	Bacterial membrane protein, YfhO
ATM22_RS07805	COG0335	large ribosomal subunit rRNA binding
ATM22_RS07810	COG0336	Belongs to the RNA methyltransferase TrmD family
ATM22_RS07815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ATM22_RS07820	COG0228	four-way junction DNA binding
ATM22_RS07825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ATM22_RS07830	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ATM22_RS07835	COG0552	protein localization to endoplasmic reticulum
ATM22_RS07840	COG1196	nuclear chromosome segregation
ATM22_RS07845	COG0571	ribonuclease III activity
ATM22_RS07850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATM22_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS07865	COG0416	fatty acid biosynthetic process
ATM22_RS07870	COG1349	DNA-binding transcription factor activity
ATM22_RS07875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ATM22_RS07880	COG1461	Dihydroxyacetone kinase
ATM22_RS07885	COG1302	Protein conserved in bacteria
ATM22_RS07890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ATM22_RS07900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ATM22_RS07905	COG1162	GTPase activity
ATM22_RS07915	COG0631	protein serine/threonine phosphatase activity
ATM22_RS07920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ATM22_RS07925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATM22_RS07925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ATM22_RS07930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATM22_RS07935	COG0242	peptide deformylase activity
ATM22_RS07945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ATM22_RS07950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ATM22_RS07955	COG1758	RNA polymerase activity
ATM22_RS07960	COG0194	GDP metabolic process
ATM22_RS07980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATM22_RS07985	COG0284	orotidine-5'-phosphate decarboxylase activity
ATM22_RS07990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ATM22_RS07995	COG0505	Belongs to the CarA family
ATM22_RS08000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATM22_RS08005	COG0540	Belongs to the ATCase OTCase family
ATM22_RS08010	COG2233	PERMEase
ATM22_RS08015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ATM22_RS08020	COG0564	pseudouridine synthase activity
ATM22_RS08025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ATM22_RS08030	COG3942	CHAP domain
ATM22_RS08030	COG1388	LysM domain
ATM22_RS08040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ATM22_RS08045	COG3599	regulation of cell shape
ATM22_RS08055	COG0762	integral membrane protein
ATM22_RS08060	COG1799	cell septum assembly
ATM22_RS08065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ATM22_RS08070	COG1496	oxidoreductase activity
ATM22_RS08075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ATM22_RS08080	COG0849	cell division
ATM22_RS08085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ATM22_RS08090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ATM22_RS08095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATM22_RS08100	COG0768	penicillin binding
ATM22_RS08105	COG4839	cell division protein FtsL
ATM22_RS08110	COG0275	rRNA processing
ATM22_RS08115	COG2001	Belongs to the MraZ family
ATM22_RS08120	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ATM22_RS08125	COG0454	-acetyltransferase
ATM22_RS08130	COG1011	Hydrolase
ATM22_RS08165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ATM22_RS08170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ATM22_RS08175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ATM22_RS08180	COG1053	succinate dehydrogenase
ATM22_RS08185	COG2009	succinate dehydrogenase
ATM22_RS08190	COG0322	excinuclease ABC activity
ATM22_RS08195	COG3118	belongs to the thioredoxin family
ATM22_RS08200	COG1193	negative regulation of DNA recombination
ATM22_RS08205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ATM22_RS08205	COG1796	DNA polymerase
ATM22_RS08215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ATM22_RS08220	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATM22_RS08225	COG0072	phenylalanine-tRNA ligase activity
ATM22_RS08225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATM22_RS08230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ATM22_RS08235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATM22_RS08245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ATM22_RS08255	COG1323	Belongs to the UPF0348 family
ATM22_RS08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ATM22_RS08265	COG0742	ribosomal rna small subunit methyltransferase
ATM22_RS08275	COG4471	UPF0298 protein
ATM22_RS08280	COG0584	glycerophosphoryl diester phosphodiesterase
ATM22_RS08285	COG3679	Belongs to the UPF0342 family
ATM22_RS08290	COG2340	Cysteine-rich secretory protein family
ATM22_RS08300	COG0109	protoheme IX farnesyltransferase activity
ATM22_RS08305	COG1612	heme a metabolic process
ATM22_RS08315	COG0772	Belongs to the SEDS family
ATM22_RS08320	COG4838	Belongs to the UPF0358 family
ATM22_RS08325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ATM22_RS08330	COG4896	Protein conserved in bacteria
ATM22_RS08340	COG1217	gtp-binding protein TYPA
ATM22_RS08350	COG0483	inositol monophosphate 1-phosphatase activity
ATM22_RS08355	COG4493	Belongs to the UPF0637 family
ATM22_RS08360	COG1914	H( )-stimulated, divalent metal cation uptake system
ATM22_RS08375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ATM22_RS08385	COG1176	ABC-type spermidine putrescine transport system, permease component I
ATM22_RS08390	COG3842	ATPase activity
ATM22_RS08400	COG4476	Belongs to the UPF0223 family
ATM22_RS08410	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATM22_RS08415	COG0022	dehydrogenase e1 component
ATM22_RS08420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ATM22_RS08430	COG0242	peptide deformylase activity
ATM22_RS08435	COG5503	Protein of unknown function (DUF1447)
ATM22_RS08440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ATM22_RS08445	COG0569	domain protein
ATM22_RS08450	COG1294	oxidase, subunit
ATM22_RS08455	COG1271	oxidase subunit
ATM22_RS08470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATM22_RS08475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATM22_RS08485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ATM22_RS08495	COG4716	Myosin-crossreactive antigen
ATM22_RS08505	COG4172	Belongs to the ABC transporter superfamily
ATM22_RS08510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ATM22_RS08515	COG0151	Belongs to the GarS family
ATM22_RS08520	COG0138	bifunctional purine biosynthesis protein purh
ATM22_RS08525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ATM22_RS08530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ATM22_RS08535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ATM22_RS08540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATM22_RS08545	COG0047	phosphoribosylformylglycinamidine synthase activity
ATM22_RS08550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATM22_RS08555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ATM22_RS08560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ATM22_RS08565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ATM22_RS08570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATM22_RS08580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATM22_RS08585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATM22_RS08590	COG1845	cytochrome c oxidase, subunit III
ATM22_RS08595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ATM22_RS08610	COG1316	TRANSCRIPTIONal
ATM22_RS08635	COG3594	Acyltransferase
ATM22_RS08640	COG0436	Aminotransferase
ATM22_RS08645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ATM22_RS08655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ATM22_RS08660	COG1169	isochorismate synthase
ATM22_RS08665	COG1575	Belongs to the MenA family. Type 1 subfamily
ATM22_RS08670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATM22_RS08675	COG2314	TM2 domain
ATM22_RS08690	COG3177	Filamentation induced by cAMP protein fic
ATM22_RS08695	COG1388	LysM domain
ATM22_RS08695	COG0860	N-Acetylmuramoyl-L-alanine amidase
ATM22_RS09030	COG4873	Protein conserved in bacteria
ATM22_RS09040	COG0737	Belongs to the 5'-nucleotidase family
ATM22_RS09045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATM22_RS09050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATM22_RS09055	COG0861	Integral membrane protein TerC family
ATM22_RS09060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ATM22_RS09070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ATM22_RS09075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATM22_RS09080	COG2814	Major facilitator Superfamily
ATM22_RS09085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ATM22_RS09090	COG2382	esterase
ATM22_RS09095	COG0628	permease
ATM22_RS09120	COG0569	domain protein
ATM22_RS09120	COG0475	glutathione-regulated potassium exporter activity
ATM22_RS09125	COG2239	Acts as a magnesium transporter
ATM22_RS09130	COG0564	pseudouridine synthase activity
ATM22_RS09135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATM22_RS09140	COG2357	RelA SpoT domain protein
ATM22_RS09155	COG2346	COG2346, Truncated hemoglobins
ATM22_RS09160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ATM22_RS09165	COG1164	Oligoendopeptidase f
ATM22_RS09175	COG4862	establishment of competence for transformation
ATM22_RS09180	COG1393	Belongs to the ArsC family
ATM22_RS09185	COG0180	Tryptophanyl-tRNA synthetase
ATM22_RS09190	COG4166	transmembrane transport
ATM22_RS09195	COG4608	Belongs to the ABC transporter superfamily
ATM22_RS09200	COG0444	Belongs to the ABC transporter superfamily
ATM22_RS09205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ATM22_RS09210	COG0601	transmembrane transport
ATM22_RS09225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATM22_RS09235	COG0542	response to heat
ATM22_RS09250	COG0561	phosphatase activity
ATM22_RS09255	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATM22_RS09275	COG0179	Fumarylacetoacetate (FAA) hydrolase
ATM22_RS09280	COG1074	ATP-dependent DNA helicase activity
ATM22_RS09285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ATM22_RS09300	COG0398	Pfam SNARE associated Golgi protein
ATM22_RS09305	COG0166	Belongs to the GPI family
ATM22_RS09310	COG0137	argininosuccinate synthase activity
ATM22_RS09315	COG0165	Argininosuccinate lyase
ATM22_RS09320	COG0584	glycerophosphoryl diester phosphodiesterase
ATM22_RS09330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATM22_RS09340	COG1902	pentaerythritol trinitrate reductase activity
ATM22_RS09345	COG1098	S1 RNA binding domain
ATM22_RS09350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ATM22_RS09360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATM22_RS09360	COG2111	Na H antiporter
ATM22_RS09365	COG2111	Na H antiporter
ATM22_RS09370	COG1006	Multisubunit Na H antiporter MnhC subunit
ATM22_RS09375	COG0651	ATP synthesis coupled electron transport
ATM22_RS09380	COG1863	multisubunit Na H antiporter MnhE subunit
ATM22_RS09385	COG2212	antiporter activity
ATM22_RS09390	COG1320	monovalent cation:proton antiporter activity
ATM22_RS09400	COG2050	protein possibly involved in aromatic compounds catabolism
ATM22_RS09405	COG2056	Na+-H+ antiporter family
ATM22_RS09410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ATM22_RS09415	COG1252	NADH dehydrogenase
ATM22_RS09420	COG0316	Belongs to the HesB IscA family
ATM22_RS09425	COG4844	belongs to the
ATM22_RS09430	COG1252	NADH dehydrogenase
ATM22_RS09435	COG4837	Protein of unknown function (DUF1462)
ATM22_RS09440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ATM22_RS09445	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ATM22_RS09450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATM22_RS09455	COG1696	Membrane protein involved in D-alanine export
ATM22_RS09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ATM22_RS09470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATM22_RS09475	COG0647	UMP catabolic process
ATM22_RS09480	COG2445	Protein of unknown function DUF86
ATM22_RS09490	COG4470	Protein conserved in bacteria
ATM22_RS09495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ATM22_RS09500	COG0737	Belongs to the 5'-nucleotidase family
ATM22_RS09505	COG0730	response to heat
ATM22_RS09510	COG1801	Protein of unknown function DUF72
ATM22_RS09515	COG1253	flavin adenine dinucleotide binding
ATM22_RS09540	COG0719	Fe-S assembly protein
ATM22_RS09545	COG0822	iron-sulfur transferase activity
ATM22_RS09550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ATM22_RS09555	COG0719	Fe-S assembly protein
ATM22_RS09560	COG0396	ATPase activity
ATM22_RS09570	COG3237	CsbD-like
ATM22_RS09580	COG1464	Belongs to the NlpA lipoprotein family
ATM22_RS09585	COG2011	ABC-type metal ion transport system permease component
ATM22_RS09590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ATM22_RS09600	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ATM22_RS09605	COG0509	glycine decarboxylation via glycine cleavage system
ATM22_RS09610	COG1393	Belongs to the ArsC family
ATM22_RS09615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATM22_RS09625	COG0710	3-dehydroquinate dehydratase activity
ATM22_RS09630	COG1764	response to oxidative stress
ATM22_RS09670	COG4195	phage-related replication protein
ATM22_RS09685	COG1278	Cold shock
ATM22_RS09715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ATM22_RS09755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ATM22_RS09760	COG0557	exoribonuclease II activity
ATM22_RS09765	COG1647	Serine aminopeptidase, S33
ATM22_RS09770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATM22_RS09780	COG0148	phosphopyruvate hydratase activity
ATM22_RS09785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ATM22_RS09790	COG0149	triose-phosphate isomerase activity
ATM22_RS09795	COG0126	phosphoglycerate kinase activity
ATM22_RS09800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ATM22_RS09820	COG1090	epimerase
ATM22_RS09830	COG0740	serine-type endopeptidase activity
ATM22_RS09840	COG1481	regulation of sporulation
ATM22_RS09845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ATM22_RS09850	COG1660	Displays ATPase and GTPase activities
ATM22_RS09855	COG0492	ferredoxin-NADP+ reductase activity
ATM22_RS09870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ATM22_RS09875	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ATM22_RS09880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ATM22_RS09885	COG0556	nucleotide-excision repair
ATM22_RS09900	COG3942	CHAP domain
ATM22_RS09900	COG1388	LysM domain
ATM22_RS09910	COG0653	protein targeting
ATM22_RS09915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ATM22_RS09920	COG1040	competence protein
ATM22_RS09925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ATM22_RS09935	COG1739	Uncharacterized protein family UPF0029
ATM22_RS09940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATM22_RS09945	COG2199	diguanylate cyclase activity
ATM22_RS09960	COG2195	Cleaves the N-terminal amino acid of tripeptides
ATM22_RS09965	COG1929	Belongs to the glycerate kinase type-1 family
ATM22_RS09985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ATM22_RS10000	COG4604	ABC transporter, ATP-binding protein
ATM22_RS10005	COG4605	iron ion homeostasis
ATM22_RS10010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATM22_RS10020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATM22_RS10025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATM22_RS10030	COG1780	Probably involved in ribonucleotide reductase function
ATM22_RS10040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ATM22_RS10045	COG3104	oligopeptide transport
ATM22_RS10055	COG1597	lipid kinase activity
ATM22_RS10060	COG1012	belongs to the aldehyde dehydrogenase family
ATM22_RS10060	COG1454	alcohol dehydrogenase
ATM22_RS10065	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ATM22_RS10070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATM22_RS10075	COG1174	glycine betaine transport
ATM22_RS10085	COG0514	ATP-dependent DNA helicase (RecQ)
ATM22_RS10090	COG0488	(ABC) transporter
ATM22_RS10105	COG1368	sulfuric ester hydrolase activity
ATM22_RS10115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ATM22_RS10130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ATM22_RS10140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ATM22_RS10145	COG0720	synthase
ATM22_RS10150	COG0602	queuosine metabolic process
ATM22_RS10170	COG0745	RESPONSE REGULATOR receiver
ATM22_RS10175	COG5002	protein histidine kinase activity
ATM22_RS10180	COG0463	Glycosyl transferase, family 2
ATM22_RS10185	COG0656	L-ascorbic acid biosynthetic process
ATM22_RS10190	COG1253	flavin adenine dinucleotide binding
ATM22_RS10195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ATM22_RS10200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATM22_RS10200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATM22_RS10200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATM22_RS10205	COG1105	Belongs to the carbohydrate kinase PfkB family
ATM22_RS10210	COG1349	DNA-binding transcription factor activity
ATM22_RS10215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ATM22_RS10240	COG0415	Belongs to the DNA photolyase family
ATM22_RS10245	COG0471	metal ion transport
ATM22_RS10250	COG0039	L-malate dehydrogenase activity
ATM22_RS10270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ATM22_RS10275	COG4988	ABC transporter
ATM22_RS10280	COG1968	undecaprenyl-diphosphatase activity
ATM22_RS10295	COG1671	Belongs to the UPF0178 family
ATM22_RS10300	COG1611	Belongs to the LOG family
ATM22_RS10325	COG2839	Protein conserved in bacteria
ATM22_RS10330	COG2814	Major facilitator Superfamily
ATM22_RS10335	COG0583	DNA-binding transcription factor activity
ATM22_RS10355	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ATM22_RS10365	COG0217	transcriptional regulatory protein
ATM22_RS10385	COG3942	CHAP domain
ATM22_RS10385	COG1388	LysM domain
ATM22_RS10390	COG0306	phosphate transporter
ATM22_RS10395	COG1392	Phosphate transport regulator
ATM22_RS10400	COG0577	efflux transmembrane transporter activity
ATM22_RS10405	COG1136	(ABC) transporter
ATM22_RS10410	COG2205	protein histidine kinase activity
ATM22_RS10415	COG0745	RESPONSE REGULATOR receiver
ATM22_RS10420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATM22_RS10435	COG3949	Membrane
ATM22_RS10445	COG1120	ATPase activity
ATM22_RS10450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ATM22_RS10460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ATM22_RS10465	COG1132	(ABC) transporter
ATM22_RS10470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ATM22_RS10480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS10485	COG1682	transport, permease protein
ATM22_RS10490	COG1134	teichoic acid transport
ATM22_RS10495	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ATM22_RS10505	COG1321	iron dependent repressor
ATM22_RS10510	COG1121	(ABC) transporter
ATM22_RS10515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATM22_RS10520	COG0803	Belongs to the bacterial solute-binding protein 9 family
ATM22_RS10530	COG1320	monovalent cation:proton antiporter activity
ATM22_RS10535	COG2212	antiporter activity
ATM22_RS10540	COG1863	multisubunit Na H antiporter MnhE subunit
ATM22_RS10545	COG0651	ATP synthesis coupled electron transport
ATM22_RS10550	COG1006	Multisubunit Na H antiporter MnhC subunit
ATM22_RS10555	COG2111	Na H antiporter
ATM22_RS10560	COG2111	Na H antiporter
ATM22_RS10560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATM22_RS10590	COG0596	Alpha beta hydrolase
ATM22_RS10610	COG0546	phosphoglycolate phosphatase activity
ATM22_RS10615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ATM22_RS10620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ATM22_RS10630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ATM22_RS10635	COG0018	arginyl-trna synthetase
ATM22_RS10650	COG1064	alcohol dehydrogenase
ATM22_RS10655	COG3875	lactate racemase activity
ATM22_RS10660	COG1606	tRNA processing
ATM22_RS10665	COG1691	(AIR) carboxylase
ATM22_RS10670	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ATM22_RS10680	COG1078	dGTPase activity
ATM22_RS10690	COG0667	Aldo Keto reductase
ATM22_RS10700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATM22_RS10705	COG4844	belongs to the
ATM22_RS10725	COG0095	Lipoate-protein ligase
ATM22_RS10730	COG0280	phosphate acetyltransferase
ATM22_RS10735	COG3253	May function as heme-dependent peroxidase
ATM22_RS10750	COG0531	amino acid
ATM22_RS10755	COG2363	Small membrane protein
ATM22_RS10765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ATM22_RS10775	COG0351	phosphomethylpyrimidine kinase
ATM22_RS10785	COG0477	Major facilitator Superfamily
ATM22_RS10800	COG0183	Belongs to the thiolase family
ATM22_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
ATM22_RS10820	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ATM22_RS10825	COG0363	glucosamine-6-phosphate deaminase activity
ATM22_RS10835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ATM22_RS10840	COG1469	GTP cyclohydrolase I activity
ATM22_RS10845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ATM22_RS10850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATM22_RS10865	COG0431	NADPH-dependent FMN reductase
ATM22_RS10870	COG0561	phosphatase activity
ATM22_RS10880	COG1428	Deoxynucleoside kinase
ATM22_RS10885	COG1428	Deoxynucleoside kinase
ATM22_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
ATM22_RS10895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATM22_RS10900	COG0546	phosphoglycolate phosphatase activity
ATM22_RS10905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ATM22_RS10910	COG1063	alcohol dehydrogenase
ATM22_RS10915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ATM22_RS10920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ATM22_RS10925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATM22_RS10945	COG1473	amidohydrolase
ATM22_RS10950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATM22_RS10955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ATM22_RS10965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATM22_RS10975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ATM22_RS10980	COG0085	RNA polymerase activity
ATM22_RS10985	COG2813	Specifically methylates the guanine in position
ATM22_RS10990	COG0222	ribosome binding
ATM22_RS10995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ATM22_RS11000	COG0081	regulation of translation
ATM22_RS11005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ATM22_RS11010	COG0250	Participates in transcription elongation, termination and antitermination
ATM22_RS11015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATM22_RS11020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATM22_RS11030	COG3688	RNA-binding protein containing a PIN domain
ATM22_RS11035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATM22_RS11040	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ATM22_RS11045	COG0215	cysteine-tRNA ligase activity
ATM22_RS11050	COG1045	serine acetyltransferase
ATM22_RS11055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATM22_RS11060	COG4956	integral membrane protein (PIN domain superfamily)
ATM22_RS11065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ATM22_RS11070	COG0542	response to heat
ATM22_RS11075	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ATM22_RS11080	COG3880	PFAM UvrB UvrC protein
ATM22_RS11085	COG4463	regulation of RNA biosynthetic process
ATM22_RS11090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ATM22_RS11095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ATM22_RS11100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ATM22_RS11105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ATM22_RS11190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATM22_RS11195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ATM22_RS11200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ATM22_RS11205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ATM22_RS11210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ATM22_RS11215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ATM22_RS11220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATM22_RS11225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ATM22_RS11230	COG0037	tRNA processing
ATM22_RS11235	COG1098	S1 RNA binding domain
ATM22_RS11245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ATM22_RS11250	COG3956	TIGRFAM MazG family protein
ATM22_RS11255	COG2244	polysaccharide biosynthetic process
ATM22_RS11260	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ATM22_RS11265	COG0193	aminoacyl-tRNA hydrolase activity
ATM22_RS11270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ATM22_RS11275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ATM22_RS11280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATM22_RS11285	COG2088	sporulation resulting in formation of a cellular spore
ATM22_RS11290	COG0251	oxidation-reduction process
ATM22_RS11295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATM22_RS11300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATM22_RS11305	COG4466	Protein conserved in bacteria
ATM22_RS11310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATM22_RS11315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ATM22_RS11320	COG0084	hydrolase, TatD family'
ATM22_RS11325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATM22_RS11325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATM22_RS11330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ATM22_RS11335	COG2827	Endonuclease containing a URI domain
ATM22_RS11340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ATM22_RS11345	COG4467	Involved in initiation control of chromosome replication
ATM22_RS11350	COG1774	PSP1 C-terminal conserved region
ATM22_RS11355	COG0470	DNA polymerase III
ATM22_RS11360	COG3870	Protein conserved in bacteria
ATM22_RS11365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ATM22_RS11370	COG1982	Orn Lys Arg decarboxylase major
ATM22_RS11395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ATM22_RS11400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ATM22_RS11405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ATM22_RS11425	COG0493	'glutamate synthase
ATM22_RS11430	COG0067	glutamate synthase
ATM22_RS11430	COG0069	glutamate synthase activity
ATM22_RS11430	COG0070	glutamate synthase
ATM22_RS11435	COG0583	DNA-binding transcription factor activity
ATM22_RS11460	COG0438	transferase activity, transferring glycosyl groups
ATM22_RS11465	COG1388	LysM domain
ATM22_RS11465	COG3942	CHAP domain
ATM22_RS11475	COG2011	ABC-type metal ion transport system permease component
ATM22_RS11480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ATM22_RS11485	COG0626	cystathionine gamma-synthase activity
ATM22_RS11490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ATM22_RS11500	COG0733	neurotransmitter:sodium symporter activity
ATM22_RS11510	COG1647	Serine aminopeptidase, S33
ATM22_RS11525	COG5609	conserved protein (DUF2294)
ATM22_RS11530	COG3002	Belongs to the UPF0753 family
ATM22_RS11535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATM22_RS11555	COG0523	cobalamin synthesis protein
ATM22_RS11570	COG0655	NAD(P)H dehydrogenase (quinone) activity
ATM22_RS11610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ATM22_RS11610	COG0519	Catalyzes the synthesis of GMP from XMP
ATM22_RS11615	COG0517	IMP dehydrogenase activity
ATM22_RS11615	COG0516	GMP reductase activity
ATM22_RS11620	COG2233	PERMEase
ATM22_RS11625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ATM22_RS11640	COG5183	chlorophyll binding
ATM22_RS11645	COG1823	symporter activity
ATM22_RS11650	COG0778	Nitroreductase
ATM22_RS11660	COG0450	alkyl hydroperoxide reductase
ATM22_RS11665	COG3634	alkyl hydroperoxide reductase activity
ATM22_RS11685	COG1280	lysine exporter protein (LysE YggA)
ATM22_RS11700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ATM22_RS11710	COG0360	Binds together with S18 to 16S ribosomal RNA
ATM22_RS11725	COG0012	GTP binding
ATM22_RS11730	COG4481	Protein conserved in bacteria
ATM22_RS11735	COG0668	transmembrane transport
ATM22_RS11740	COG1475	DNA binding
ATM22_RS11745	COG0626	cystathionine gamma-synthase activity
ATM22_RS11750	COG0626	cystathionine gamma-synthase activity
ATM22_RS11755	COG0646	methionine synthase
ATM22_RS11755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ATM22_RS11760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ATM22_RS11770	COG0183	Belongs to the thiolase family
ATM22_RS11780	COG1476	TRANSCRIPTIONal
ATM22_RS11790	COG4555	ABC transporter
ATM22_RS11810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ATM22_RS11850	COG1136	(ABC) transporter
ATM22_RS11855	COG0577	efflux transmembrane transporter activity
ATM22_RS11875	COG0577	efflux transmembrane transporter activity
ATM22_RS11880	COG1136	(ABC) transporter
ATM22_RS11915	COG1475	DNA binding
ATM22_RS11920	COG0357	Ribosomal RNA small subunit methyltransferase G
ATM22_RS11925	COG0445	tRNA wobble uridine modification
ATM22_RS11930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ATM22_RS11935	COG0594	ribonuclease P activity