locus-tag	class	description
F1614_RS00020	ENOG4105C9Q	fumarate hydratase class II
F1614_RS00025	ENOG4108YBP	pseudouridine synthase
F1614_RS00030	ENOG4105BZU	Histidine kinase
F1614_RS00035	ENOG4105WH1	Two component transcriptional regulator luxr family
F1614_RS00045	ENOG4108UH6	UPF0754 membrane protein
F1614_RS00050	ENOG4105WZB	UPF0342 protein
F1614_RS00055	ENOG4107VRP	DNA repair exonuclease
F1614_RS00065	ENOG4105EQI	Metal Dependent Phosphohydrolase
F1614_RS00075	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
F1614_RS00090	ENOG4105K59	histidine triad (HIT) protein
F1614_RS00110	ENOG4105Q24	Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation
F1614_RS00115	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
F1614_RS00120	ENOG4107TTW	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
F1614_RS00125	ENOG4105C1Q	protoporphyrinogen oxidase
F1614_RS00205	ENOG4105CEY	Amp-dependent synthetase and ligase
F1614_RS00215	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
F1614_RS00230	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
F1614_RS00235	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
F1614_RS00250	ENOG4106A8V	Protein CrcB homolog
F1614_RS00255	ENOG4106A8V	Protein CrcB homolog
F1614_RS00265	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
F1614_RS00295	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
F1614_RS00305	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
F1614_RS00310	ENOG4108R6K	riboflavin synthase, subunit alpha
F1614_RS00315	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
F1614_RS00320	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
F1614_RS00330	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
F1614_RS00345	ENOG4105N5T	Radical SAM Protein
F1614_RS00350	ENOG410605W	Major Facilitator
F1614_RS00355	ENOG4105C8T	Leucyl-tRNA synthetase
F1614_RS00370	ENOG4105CBX	hi0933 family
F1614_RS00390	ENOG4107QSE	Dipeptidase
F1614_RS00395	ENOG4105F0I	Aminotransferase
F1614_RS00400	ENOG4108V15	phosphotransferase enzyme family
F1614_RS00405	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
F1614_RS00425	ENOG4108NKM	UPF0354 protein
F1614_RS00430	ENOG4108VDD	TRNA binding domain protein
F1614_RS00440	ENOG4105DFU	Cell wall formation (By similarity)
F1614_RS00445	ENOG4105MQN	general stress protein
F1614_RS00455	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
F1614_RS00460	ENOG4105ETE	Transcriptional regulator (LacI family
F1614_RS00465	ENOG4105CKU	formyltetrahydrofolate synthetase
F1614_RS00475	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
F1614_RS00480	ENOG4105C0H	protease
F1614_RS00485	ENOG4105F6E	Acyl-transferase
F1614_RS00500	ENOG4108JQ1	Dehydrogenase
F1614_RS00510	ENOG4108X3M	OsmC Ohr family protein
F1614_RS00515	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
F1614_RS00520	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
F1614_RS00535	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
F1614_RS00540	ENOG4108RS6	transposase
F1614_RS00550	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
F1614_RS00560	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
F1614_RS00570	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
F1614_RS00575	ENOG4107YZX	Universal stress protein
F1614_RS00580	ENOG4105DCF	alanine dehydrogenase
F1614_RS00585	ENOG4105DC7	peptidase M24
F1614_RS00590	ENOG4105E8R	UPF0173 metal-dependent hydrolase
F1614_RS00605	ENOG4105SFS	phosphoesterase RecJ domain protein
F1614_RS00610	ENOG4105C0B	DNA polymerase III (alpha subunit)
F1614_RS00615	ENOG4105C6K	Malic enzyme
F1614_RS00620	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
F1614_RS00625	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
F1614_RS00630	ENOG4105CTQ	phosphohexokinase
F1614_RS00635	ENOG4105CA9	Pyruvate kinase
F1614_RS00640	ENOG4108RS6	transposase
F1614_RS00645	ENOG4105C85	amino acid
F1614_RS00650	ENOG4105BZN	citrate synthase
F1614_RS00655	ENOG4108HMX	isocitrate dehydrogenase (NADP)
F1614_RS00660	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
F1614_RS00665	ENOG4105BZU	Histidine kinase
F1614_RS00670	ENOG4105C2M	dna polymerase I
F1614_RS00675	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
F1614_RS00680	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
F1614_RS00695	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
F1614_RS00700	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
F1614_RS00715	ENOG4105C22	threonyL-tRNA synthetase
F1614_RS00720	ENOG4108IQI	permease
F1614_RS00725	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
F1614_RS00730	ENOG4105VJV	50s ribosomal protein L35
F1614_RS00735	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
F1614_RS00740	ENOG4105U6W	MutT NUDIX family protein
F1614_RS00750	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
F1614_RS00755	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
F1614_RS00760	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
F1614_RS00765	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
F1614_RS00775	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
F1614_RS00785	ENOG4105D52	delta-aminolevulinic acid dehydratase
F1614_RS00790	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
F1614_RS00800	ENOG4108R3E	Dna-3-methyladenine glycosylase i
F1614_RS00805	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
F1614_RS00810	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
F1614_RS00820	ENOG4105W5Q	DNA repair protein (RadC
F1614_RS00840	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
F1614_RS00850	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
F1614_RS00855	ENOG4105X36	(ribosomal) protein
F1614_RS00860	ENOG4105K46	50S ribosomal protein l27
F1614_RS00865	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1614_RS00870	ENOG41090I5	UPF0735 ACT domain-containing protein
F1614_RS00875	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
F1614_RS00880	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
F1614_RS00885	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
F1614_RS00890	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
F1614_RS00895	ENOG4105VIE	preprotein translocase, subunit YajC
F1614_RS00900	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
F1614_RS00905	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
F1614_RS00910	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
F1614_RS00920	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
F1614_RS00925	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
F1614_RS00930	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
F1614_RS00935	ENOG4105CUT	histidyl-tRNA synthetase
F1614_RS00940	ENOG4105C9M	aspartyl-trna synthetase
F1614_RS00950	ENOG4105CUZ	uba thif-type nad fad binding protein
F1614_RS00955	ENOG4105D1H	recombination factor protein RarA
F1614_RS00970	ENOG4105DEN	Luciferase family
F1614_RS00975	ENOG4105C3J	Cysteine desulfurase
F1614_RS00980	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
F1614_RS00990	ENOG4105C7H	Helicase, RecD TraA family
F1614_RS00995	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
F1614_RS01000	ENOG4105VBH	UPF0297 protein
F1614_RS01005	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
F1614_RS01010	ENOG4105VPH	UPF0473 protein
F1614_RS01020	ENOG4105XYU	peptidase (U32 family)
F1614_RS01025	ENOG4105CFP	Peptidase U32
F1614_RS01030	ENOG4105DBI	uridine monophosphokinase
F1614_RS01035	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
F1614_RS01040	ENOG4105P4J	Allophanate hydrolase, subunit 1
F1614_RS01050	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
F1614_RS01055	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
F1614_RS01060	ENOG4105E7W	lamb ycsf family protein
F1614_RS01065	ENOG4105C5A	transporter
F1614_RS01070	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
F1614_RS01075	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
F1614_RS01080	ENOG4105CQW	ribosome biogenesis GTPase YqeH
F1614_RS01085	ENOG4105E2X	shikimate dehydrogenase
F1614_RS01090	ENOG410812S	Rna-binding protein
F1614_RS01095	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
F1614_RS01100	ENOG4108WF2	Metal Dependent Phosphohydrolase
F1614_RS01105	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
F1614_RS01110	ENOG4108D32	Methyltransferase
F1614_RS01120	ENOG4108UK2	deaminase
F1614_RS01125	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
F1614_RS01130	ENOG4105TQK	DNA polymerase iii, delta' subunit
F1614_RS01135	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
F1614_RS01140	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
F1614_RS01145	ENOG4105CSA	Coproporphyrinogen iii oxidase
F1614_RS01150	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
F1614_RS01155	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1614_RS01160	ENOG4105CFG	Acts as a chaperone (By similarity)
F1614_RS01165	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
F1614_RS01170	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
F1614_RS01175	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
F1614_RS01180	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
F1614_RS01190	ENOG4105F7J	membrane-bound serine protease
F1614_RS01195	ENOG4105DI5	UPF0365 protein
F1614_RS01205	ENOG4105C9A	Phoh family
F1614_RS01210	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
F1614_RS01215	ENOG41080IJ	Diacylglycerol kinase
F1614_RS01220	ENOG4105KG3	cytidine deaminase
F1614_RS01225	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
F1614_RS01230	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
F1614_RS01235	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
F1614_RS01245	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
F1614_RS01250	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
F1614_RS01255	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
F1614_RS01265	ENOG4105EGD	dinuclear metal center protein, YbgI family
F1614_RS01270	ENOG4105C1J	atp-dependent rna helicase
F1614_RS01275	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
F1614_RS01280	ENOG4105FDK	ABC transporter
F1614_RS01285	ENOG4105FAV	ABC, transporter
F1614_RS01290	ENOG4105N80	Ferric uptake regulator, Fur family
F1614_RS01295	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
F1614_RS01300	ENOG4107RF6	penicillin-binding protein
F1614_RS01305	ENOG4105WDJ	50S ribosomal protein L33
F1614_RS01310	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
F1614_RS01315	ENOG4107U91	Rhomboid family
F1614_RS01345	ENOG4105D7Q	type ii secretion system
F1614_RS01350	ENOG4106855	Competence protein
F1614_RS01370	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
F1614_RS01375	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
F1614_RS01380	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1614_RS01385	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1614_RS01395	ENOG4105WZW	rhodanese family
F1614_RS01400	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
F1614_RS01415	ENOG4105DC7	peptidase M24
F1614_RS01420	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
F1614_RS01425	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
F1614_RS01430	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
F1614_RS01435	ENOG4105CAS	nag kinase
F1614_RS01440	ENOG4105C8Y	Acetylornithine aminotransferase
F1614_RS01450	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
F1614_RS01455	ENOG4108ZSR	alkaline shock protein
F1614_RS01460	ENOG4105M7K	Involved in the transcription termination process (By similarity)
F1614_RS01465	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
F1614_RS01470	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
F1614_RS01480	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
F1614_RS01485	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
F1614_RS01500	ENOG4105CPP	Dehydrogenase, E1 component
F1614_RS01505	ENOG4105C7S	Dehydrogenase
F1614_RS01510	ENOG4108Y6J	UPF0403 protein
F1614_RS01515	ENOG4108QEG	Membrane
F1614_RS01525	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
F1614_RS01530	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
F1614_RS01550	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
F1614_RS01555	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
F1614_RS01560	ENOG4105II7	pyrroline-5-carboxylate reductase
F1614_RS01565	ENOG4108QJ2	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
F1614_RS01570	ENOG4105CPC	Aldo Keto reductase
F1614_RS01575	ENOG4108YZ4	nudix hydrolase
F1614_RS01580	ENOG4105I3K	Ferric uptake regulator, Fur family
F1614_RS01585	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
F1614_RS01595	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
F1614_RS01600	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
F1614_RS01605	ENOG4105FE9	pseudouridine synthase
F1614_RS01610	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
F1614_RS01615	ENOG4105BZU	Histidine kinase
F1614_RS01640	ENOG4105C9U	ATP-dependent DNA helicase RecQ
F1614_RS01645	ENOG4106BU8	elastin-binding protein ebpS
F1614_RS01650	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
F1614_RS01655	ENOG4107RB3	L-asparaginase
F1614_RS01660	ENOG4105CAT	Cytidine monophosphate kinase
F1614_RS01665	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
F1614_RS01670	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
F1614_RS01675	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
F1614_RS01680	ENOG4105K70	DNA-binding protein
F1614_RS01690	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
F1614_RS01700	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
F1614_RS01705	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
F1614_RS01710	ENOG4105D49	3-dehydroquinate synthase
F1614_RS01715	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
F1614_RS01725	ENOG4105QKB	UPF0302 protein
F1614_RS01740	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
F1614_RS01745	ENOG4105CPK	Glycosyl transferase (Group 1
F1614_RS01750	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
F1614_RS01760	ENOG4105DVT	helicase
F1614_RS01765	ENOG4105C5S	asparaginyl-tRNA synthetase
F1614_RS01775	ENOG4105CSM	endonuclease III
F1614_RS01785	ENOG4105BZ4	penicillin-binding protein
F1614_RS01790	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
F1614_RS01800	ENOG4108UKS	UPF0398 protein
F1614_RS01805	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
F1614_RS01815	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
F1614_RS01825	ENOG410890F	Dynamin family
F1614_RS01860	ENOG4106QQ5	PBS lyase HEAT domain protein repeat-containing protein
F1614_RS01865	ENOG4108Y6J	UPF0403 protein
F1614_RS01875	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
F1614_RS01885	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
F1614_RS01895	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
F1614_RS01900	ENOG4105E0X	reductase
F1614_RS01905	ENOG4105C5Y	PTS System
F1614_RS01910	ENOG4106E6V	UPF0346 protein
F1614_RS01915	ENOG4105CN1	protease
F1614_RS01930	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
F1614_RS01935	ENOG410841Q	phosphoesterase PA-phosphatase related protein
F1614_RS01940	ENOG4108IJ9	(ABC) transporter
F1614_RS01955	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
F1614_RS01965	ENOG4105UQX	Mate efflux family protein
F1614_RS01970	ENOG4105E98	transcriptional regulator DeoR family
F1614_RS01980	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
F1614_RS01985	ENOG4105GR3	Histidine kinase
F1614_RS01995	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
F1614_RS02000	ENOG4105C7S	Dehydrogenase
F1614_RS02020	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
F1614_RS02025	ENOG4107T89	von Willebrand factor, type A
F1614_RS02030	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
F1614_RS02035	ENOG4105CDW	Resistance protein
F1614_RS02045	ENOG410855V	Acylphosphatase
F1614_RS02055	ENOG4105VEQ	Cold shock protein
F1614_RS02070	ENOG4105CJ1	ABC, transporter
F1614_RS02080	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
F1614_RS02085	ENOG4108XFP	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
F1614_RS02090	ENOG4105CH2	amidohydrolase
F1614_RS02095	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
F1614_RS02100	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
F1614_RS02105	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
F1614_RS02110	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
F1614_RS02115	ENOG4105CFH	Aspartokinase
F1614_RS02120	ENOG4105C5H	ABC transporter
F1614_RS02125	ENOG4105QNR	S1 RNA binding domain protein
F1614_RS02130	ENOG4105CVA	phosphate
F1614_RS02135	ENOG4105C8U	phosphate abc transporter
F1614_RS02140	ENOG4105E2Z	phosphate ABC transporter (Permease
F1614_RS02145	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS02150	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
F1614_RS02155	ENOG4105DPN	Oligoendopeptidase f
F1614_RS02170	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
F1614_RS02195	ENOG4108TV1	Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity)
F1614_RS02200	ENOG4108RMH	femAB family
F1614_RS02215	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
F1614_RS02220	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
F1614_RS02225	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
F1614_RS02230	ENOG4105DK0	Indole-3-glycerol phosphate synthase
F1614_RS02235	ENOG4108I0Q	anthranilate phosphoribosyltransferase
F1614_RS02240	ENOG4105DDQ	anthranilate synthase
F1614_RS02245	ENOG4105CRQ	synthase (Component I)
F1614_RS02250	ENOG4105EVN	Prephenate dehydrogenase
F1614_RS02255	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
F1614_RS02260	ENOG41069HH	4-oxalocrotonate tautomerase
F1614_RS02265	ENOG4108RCF	TRANSCRIPTIONal
F1614_RS02270	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
F1614_RS02275	ENOG4105FF5	Membrane
F1614_RS02285	ENOG4105CID	antiterminator
F1614_RS02295	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1614_RS02300	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1614_RS02305	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
F1614_RS02320	ENOG4108I0Z	Aconitate hydratase
F1614_RS02325	ENOG4105C94	Transporter
F1614_RS02330	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
F1614_RS02335	ENOG4105EYH	Exonuclease
F1614_RS02340	ENOG4107RFY	SbcCD D subunit
F1614_RS02355	ENOG4105CV1	Transketolase (EC 2.2.1.1)
F1614_RS02360	ENOG4105VPS	UPF0291 protein
F1614_RS02370	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
F1614_RS02380	ENOG4106UY4	Inherit from COG: Scp-like extracellular
F1614_RS02385	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
F1614_RS02390	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
F1614_RS02400	ENOG4105CH6	catalase
F1614_RS02405	ENOG4108IQI	permease
F1614_RS02420	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
F1614_RS02425	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
F1614_RS02430	ENOG4105D6E	homoserine dehydrogenase
F1614_RS02435	ENOG4105CFH	Aspartokinase
F1614_RS02465	ENOG4108ZGX	Histidine kinase
F1614_RS02475	ENOG4105CJ1	ABC, transporter
F1614_RS02480	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
F1614_RS02515	ENOG4105C5F	glutamine synthetase
F1614_RS02520	ENOG4105KV4	Transcriptional regulator
F1614_RS02525	ENOG4105CXI	aluminum resistance protein
F1614_RS02530	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
F1614_RS02535	ENOG4108V06	Glutathione peroxidase
F1614_RS02540	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
F1614_RS02545	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
F1614_RS02555	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
F1614_RS02560	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
F1614_RS02570	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
F1614_RS02575	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
F1614_RS02580	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
F1614_RS02595	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
F1614_RS02605	ENOG4105K7W	phage-related replication protein
F1614_RS02610	ENOG4105DQU	oxidoreductase, subunit beta
F1614_RS02615	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
F1614_RS02620	ENOG4105D48	metallophosphoesterase
F1614_RS02630	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
F1614_RS02635	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
F1614_RS02640	ENOG4105CEV	competence damage-inducible protein
F1614_RS02650	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
F1614_RS02665	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
F1614_RS02680	ENOG4105FDP	GntR family transcriptional regulator
F1614_RS02685	ENOG4105CNU	cell division protein FtsK
F1614_RS02690	ENOG4105CN5	Metallo-Beta-Lactamase
F1614_RS02695	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
F1614_RS02700	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
F1614_RS02705	ENOG4105DTN	riboflavin biosynthesis protein ribF
F1614_RS02710	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
F1614_RS02715	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
F1614_RS02720	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
F1614_RS02725	ENOG4105VHM	ribosomal protein
F1614_RS02730	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
F1614_RS02735	ENOG4105CHV	Transcription elongation factor NusA
F1614_RS02740	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
F1614_RS02745	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
F1614_RS02750	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
F1614_RS02760	ENOG4105KNE	Phosphatidate cytidylyltransferase
F1614_RS02765	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
F1614_RS02770	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
F1614_RS02775	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
F1614_RS02780	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
F1614_RS02785	ENOG4105CE9	30S ribosomal protein S2
F1614_RS02790	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
F1614_RS02795	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
F1614_RS02800	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
F1614_RS02805	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
F1614_RS02810	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
F1614_RS02815	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
F1614_RS02820	ENOG4105C79	DNA protecting protein DprA
F1614_RS02825	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
F1614_RS02830	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
F1614_RS02835	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
F1614_RS02850	ENOG4105EJV	Membrane
F1614_RS02860	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
F1614_RS02865	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
F1614_RS02870	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
F1614_RS02875	ENOG4105K5M	30s ribosomal protein S16
F1614_RS02885	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
F1614_RS02890	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
F1614_RS02895	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
F1614_RS02900	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
F1614_RS02905	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
F1614_RS02910	ENOG4105CHR	reductase
F1614_RS02920	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
F1614_RS02925	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
F1614_RS02930	ENOG4105CB5	ATP-dependent DNA helicase recG
F1614_RS02935	ENOG4105DP4	dak2 domain fusion protein ylov
F1614_RS02940	ENOG4108ZAA	Alkaline-shock protein
F1614_RS02945	ENOG4105VB9	50S ribosomal protein l28
F1614_RS02955	ENOG4105DJV	ribulose-phosphate 3-epimerase
F1614_RS02960	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
F1614_RS02970	ENOG4108ZF3	Phosphatase
F1614_RS02975	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
F1614_RS02980	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
F1614_RS02985	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
F1614_RS02990	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
F1614_RS03000	ENOG4105C25	Primosomal protein n'
F1614_RS03005	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
F1614_RS03010	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
F1614_RS03015	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
F1614_RS03020	ENOG4105F23	Fibronectin-binding protein
F1614_RS03035	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
F1614_RS03040	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
F1614_RS03045	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
F1614_RS03050	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
F1614_RS03055	ENOG4105CD3	dihydroorotase
F1614_RS03060	ENOG4105CXT	aspartate transcarbamylase
F1614_RS03070	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
F1614_RS03075	ENOG4105C34	Pseudouridine synthase
F1614_RS03080	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
F1614_RS03085	ENOG4105VRS	hydrolase family 18
F1614_RS03095	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
F1614_RS03110	ENOG41067XK	integral membrane protein
F1614_RS03115	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
F1614_RS03120	ENOG4105DFA	alanine racemase domain protein
F1614_RS03125	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
F1614_RS03130	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
F1614_RS03135	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
F1614_RS03140	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
F1614_RS03145	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
F1614_RS03150	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
F1614_RS03155	ENOG4105CJN	penicillin-binding protein
F1614_RS03160	ENOG41068DC	Essential cell division protein (By similarity)
F1614_RS03165	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
F1614_RS03170	ENOG4108V6E	Cell division protein mraZ
F1614_RS03175	ENOG41074B2	UPF0747 protein
F1614_RS03180	ENOG4108YG3	N-acetyltransferase
F1614_RS03220	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
F1614_RS03225	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
F1614_RS03230	ENOG4105E33	succinate dehydrogenase
F1614_RS03240	ENOG4108NU2	Succinate dehydrogenase cytochrome b558 subunit
F1614_RS03245	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
F1614_RS03250	ENOG4105K63	Thioredoxin
F1614_RS03255	ENOG4105C98	muts2 protein
F1614_RS03260	ENOG4105DCG	PHP domain protein
F1614_RS03270	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
F1614_RS03275	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
F1614_RS03280	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
F1614_RS03285	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
F1614_RS03290	ENOG4108RWN	rrna methyltransferase
F1614_RS03300	ENOG4108M1Z	surface protein
F1614_RS03305	ENOG41067VY	50S ribosomal protein L32
F1614_RS03315	ENOG4105CDE	UPF0348 protein
F1614_RS03320	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
F1614_RS03325	ENOG4106H78	methyltransferase
F1614_RS03335	ENOG4105WUC	UPF0298 protein
F1614_RS03345	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
F1614_RS03355	ENOG4106UY4	Inherit from COG: Scp-like extracellular
F1614_RS03365	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
F1614_RS03370	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
F1614_RS03375	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
F1614_RS03380	ENOG4105CNI	cell division protein FtsW
F1614_RS03385	ENOG4105ZPI	UPF0358 protein
F1614_RS03405	ENOG4105CI3	gtp-binding protein typa
F1614_RS03415	ENOG4105ECY	inositol monophosphatase
F1614_RS03420	ENOG4108WQ8	UPF0637 protein
F1614_RS03425	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
F1614_RS03450	ENOG4105F38	ABC transporter, permease
F1614_RS03455	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS03465	ENOG4105WBI	UPF0223 protein
F1614_RS03470	ENOG4107QN2	dihydrolipoyl dehydrogenase
F1614_RS03475	ENOG4105C7S	Dehydrogenase
F1614_RS03480	ENOG4105CPP	Dehydrogenase, E1 component
F1614_RS03485	ENOG4107RUY	(E1 component), alpha subunit
F1614_RS03495	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
F1614_RS03500	ENOG4106148	UPF0356 protein
F1614_RS03505	ENOG4105CN5	Metallo-Beta-Lactamase
F1614_RS03510	ENOG4107ZYR	domain protein
F1614_RS03530	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
F1614_RS03545	ENOG4105DR4	Methyltransferase
F1614_RS03560	ENOG4105CCI	Myosin-Cross-Reactive Antigen
F1614_RS03570	ENOG4108JJB	ABC transporter
F1614_RS03575	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
F1614_RS03580	ENOG4105C12	Phosphoribosylglycinamide synthetase
F1614_RS03585	ENOG4105DC1	bifunctional purine biosynthesis protein purh
F1614_RS03590	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
F1614_RS03595	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
F1614_RS03600	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
F1614_RS03605	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
F1614_RS03610	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
F1614_RS03615	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
F1614_RS03620	ENOG4105C8V	SAICAR synthetase
F1614_RS03625	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
F1614_RS03630	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
F1614_RS03635	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
F1614_RS03645	ENOG4105E2S	oxidase) subunit II
F1614_RS03650	ENOG4105BZ9	Cytochrome C oxidase, subunit I
F1614_RS03655	ENOG4105CCU	oxidase (Subunit III)
F1614_RS03660	ENOG41060D1	Quinol oxidase
F1614_RS03670	ENOG4108A04	Beta-lactamase
F1614_RS03675	ENOG4108KGH	TRANSCRIPTIONal
F1614_RS03685	ENOG41082BV	acetyltransferase
F1614_RS03690	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
F1614_RS03700	ENOG4108TGC	Acyltransferase
F1614_RS03705	ENOG4105CHM	Aminotransferase
F1614_RS03710	ENOG4108IPT	Naphthoate synthase
F1614_RS03720	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
F1614_RS03725	ENOG4105E4F	Isochorismate synthase
F1614_RS03735	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
F1614_RS03740	ENOG4108MK9	spermidine N(1)-acetyltransferase
F1614_RS03750	ENOG4105YB8	TM2 domain containing protein
F1614_RS03795	ENOG4105K7W	phage-related replication protein
F1614_RS04010	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
F1614_RS04080	ENOG4105CGH	5'-nucleotidase
F1614_RS04095	ENOG4107TS3	membrane protein, TerC
F1614_RS04100	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
F1614_RS04110	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
F1614_RS04115	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
F1614_RS04120	ENOG4108PK2	permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence
F1614_RS04135	ENOG4105C02	permease
F1614_RS04255	ENOG4105CJW	magnesium transporter
F1614_RS04260	ENOG4105EMS	pseudouridine synthase
F1614_RS04265	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
F1614_RS04275	ENOG4106EFP	UPF0738 protein
F1614_RS04285	ENOG4108Z18	K06886 hemoglobin
F1614_RS04290	ENOG4105T58	Dithiol-disulfide isomerase
F1614_RS04295	ENOG4105DPN	Oligoendopeptidase f
F1614_RS04305	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
F1614_RS04310	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
F1614_RS04315	ENOG4105C31	Tryptophanyl-tRNA synthetase
F1614_RS04320	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
F1614_RS04330	ENOG4108JQ7	(ABC) transporter
F1614_RS04335	ENOG4105C3U	ABC transporter
F1614_RS04350	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
F1614_RS04365	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
F1614_RS04380	ENOG4108KP7	hydrolase
F1614_RS04385	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
F1614_RS04390	ENOG4106BKT	UPF0344 protein
F1614_RS04395	ENOG4105ERH	Fumarylacetoacetate hydrolase
F1614_RS04400	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
F1614_RS04405	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F1614_RS04410	ENOG4105C3F	Signal peptidase i
F1614_RS04425	ENOG4107QYV	phosphohexose isomerase
F1614_RS04430	ENOG4105CDH	Citrulline--aspartate ligase
F1614_RS04435	ENOG4105CH7	arginosuccinase
F1614_RS04440	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
F1614_RS04445	ENOG4105D82	Glutamate dehydrogenase
F1614_RS04450	ENOG4105C8Y	Acetylornithine aminotransferase
F1614_RS04460	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
F1614_RS04465	ENOG41060GV	RNA binding s1 domain protein
F1614_RS04470	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
F1614_RS04480	ENOG4105D65	subunit l
F1614_RS04490	ENOG4105MKQ	Monovalent cation H antiporter subunit C
F1614_RS04495	ENOG4108JPZ	Monovalent cation H antiporter subunit D
F1614_RS04500	ENOG4105SC1	monovalent cation H antiporter subunit E
F1614_RS04505	ENOG4105W4C	monovalent cation H antiporter subunit F
F1614_RS04510	ENOG4105KJM	monovalent cation h antiporter subunit g
F1614_RS04520	ENOG4105KA0	thioesterase Superfamily protein
F1614_RS04530	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
F1614_RS04535	ENOG4105CEP	NADH dehydrogenase
F1614_RS04540	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
F1614_RS04545	ENOG4105ZKE	UPF0349 protein
F1614_RS04560	ENOG41083MR	nifu domain-containing protein
F1614_RS04565	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
F1614_RS04570	ENOG4106C1H	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
F1614_RS04575	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
F1614_RS04580	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
F1614_RS04590	ENOG4105C5I	Dehydrogenase
F1614_RS04595	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
F1614_RS04610	ENOG4105MMD	transcriptional regulator
F1614_RS04615	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
F1614_RS04620	ENOG4107R8B	5'-nucleotidase
F1614_RS04630	ENOG4105I3N	Conserved Protein
F1614_RS04665	ENOG4105DIW	FeS assembly protein SUFB
F1614_RS04670	ENOG4108UNV	SUF system FeS assembly protein, NifU family
F1614_RS04675	ENOG4105C9B	Cysteine desulfurase
F1614_RS04680	ENOG4105JRK	feS assembly protein SufD
F1614_RS04685	ENOG4105C3K	feS assembly ATPase SufC
F1614_RS04695	ENOG41061M1	UPF0337 protein
F1614_RS04705	ENOG4105D01	(LipO)protein
F1614_RS04710	ENOG4108UMI	ABC transporter, permease
F1614_RS04715	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS04735	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
F1614_RS04740	ENOG41080E8	Transcriptional regulator, Spx MgsR family
F1614_RS04745	ENOG4105SZ6	Thioredoxin
F1614_RS04755	ENOG4105FF2	Type I DHQase
F1614_RS04760	ENOG4108ZHJ	Organic hydroperoxide resistance protein
F1614_RS04805	ENOG4105K7W	phage-related replication protein
F1614_RS04820	ENOG4105VEQ	Cold shock protein
F1614_RS04830	ENOG4105PGM	cation diffusion facilitator family transporter
F1614_RS04860	ENOG4105CZN	Potassium uptake protein
F1614_RS04905	ENOG4108TFU	terminase (Small subunit)
F1614_RS04925	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
F1614_RS04930	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
F1614_RS04940	ENOG4105XZU	Preprotein translocase, subunit SecG
F1614_RS04950	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
F1614_RS04955	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
F1614_RS04960	ENOG4105CP7	Triose-phosphate isomerase
F1614_RS04965	ENOG4105BZA	Phosphoglycerate kinase
F1614_RS04970	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
F1614_RS04990	ENOG4105ECP	epimerase
F1614_RS05000	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
F1614_RS05010	ENOG4105CIE	May be required for sporulation (By similarity)
F1614_RS05015	ENOG4105CHW	UPF0052 protein
F1614_RS05020	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
F1614_RS05025	ENOG4105C3M	thioredoxin reductase
F1614_RS05040	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
F1614_RS05045	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
F1614_RS05050	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
F1614_RS05055	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
F1614_RS05075	ENOG41068JE	domain protein
F1614_RS05085	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
F1614_RS05090	ENOG4105MS2	ribosomal subunit Interface protein
F1614_RS05095	ENOG41081UC	Inherit from COG: Competence protein
F1614_RS05110	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
F1614_RS05115	ENOG4105ESV	Glycosyl transferase, family 4
F1614_RS05120	ENOG4105BZU	Histidine kinase
F1614_RS05135	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
F1614_RS05140	ENOG4105BZW	Glycerate kinase
F1614_RS05160	ENOG4105D4A	Cell wall formation (By similarity)
F1614_RS05175	ENOG4108IPW	abc transporter atp-binding protein
F1614_RS05180	ENOG4105CM4	permease protein
F1614_RS05185	ENOG4105DHS	permease protein
F1614_RS05195	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
F1614_RS05200	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
F1614_RS05205	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
F1614_RS05215	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
F1614_RS05220	ENOG4105DUX	Transporter
F1614_RS05230	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
F1614_RS05235	ENOG4108EKI	Dehydrogenase
F1614_RS05240	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
F1614_RS05245	ENOG4105CIH	Imidazole acetol-phosphate transaminase
F1614_RS05255	ENOG4108IJ8	ABC transporter
F1614_RS05260	ENOG4105C9U	ATP-dependent DNA helicase RecQ
F1614_RS05265	ENOG4105C5H	ABC transporter
F1614_RS05280	ENOG4105E0M	Sulfatase
F1614_RS05290	ENOG4105P4J	Allophanate hydrolase, subunit 1
F1614_RS05305	ENOG4105CRQ	synthase (Component I)
F1614_RS05310	ENOG4105DDQ	anthranilate synthase
F1614_RS05315	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
F1614_RS05320	ENOG4107ZAE	6-carboxy-5,6,7,8-tetrahydropterin synthase
F1614_RS05325	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
F1614_RS05345	ENOG4108WZ2	response regulator
F1614_RS05350	ENOG4108YBA	Histidine kinase
F1614_RS05355	ENOG4105CKK	Glycosyl transferase, family 2
F1614_RS05370	ENOG4105C37	(CBS) domain
F1614_RS05375	ENOG4105CE4	GlcNAc 6-P deacetylase
F1614_RS05380	ENOG4105DM4	PTS System
F1614_RS05385	ENOG4105DE4	1-phosphofructokinase
F1614_RS05390	ENOG4105E98	transcriptional regulator DeoR family
F1614_RS05400	ENOG4108Z66	YbaK ebsC protein
F1614_RS05410	ENOG4105DP8	Major facilitator superfamily MFS_1
F1614_RS05425	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
F1614_RS05430	ENOG4107QPK	)-transporter
F1614_RS05435	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
F1614_RS05455	ENOG41083AI	transcriptional regulator), MarR family
F1614_RS05460	ENOG4108JJ8	(ABC) transporter
F1614_RS05465	ENOG4108JJ9	ABC, transporter
F1614_RS05470	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
F1614_RS05485	ENOG4107XJU	UPF0178 protein
F1614_RS05490	ENOG4108URH	decarboxylase
F1614_RS05515	ENOG4105SXS	Protein of unknown function (DUF456)
F1614_RS05520	ENOG4105S8Q	sugar efflux transporter
F1614_RS05545	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
F1614_RS05555	ENOG4105CDY	transcriptional regulatory protein
F1614_RS05575	ENOG4105VRS	hydrolase family 18
F1614_RS05580	ENOG4105CJ3	phosphate transporter
F1614_RS05585	ENOG4107GRR	phosphate transport regulator
F1614_RS05595	ENOG4105C19	ABC transporter
F1614_RS05600	ENOG4105EWM	Histidine kinase
F1614_RS05605	ENOG4105CJZ	response regulator
F1614_RS05625	ENOG4108K88	Membrane
F1614_RS05635	ENOG4105E0A	ABC, transporter
F1614_RS05640	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
F1614_RS05655	ENOG4105BZ1	(ABC) transporter
F1614_RS05670	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
F1614_RS05690	ENOG4105EY8	ABC transporter
F1614_RS05695	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
F1614_RS05705	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
F1614_RS05710	ENOG4105DIK	(ABC) transporter
F1614_RS05715	ENOG4105CC5	ABC transporter
F1614_RS05720	ENOG4105DSE	periplasmic solute binding protein
F1614_RS05725	ENOG4105EEQ	Na H antiporter
F1614_RS05735	ENOG410684G	monovalent cation H antiporter subunit F
F1614_RS05740	ENOG4105IMY	monovalent cation H antiporter subunit E
F1614_RS05745	ENOG4108JPZ	Monovalent cation H antiporter subunit D
F1614_RS05750	ENOG4105MKQ	Monovalent cation H antiporter subunit C
F1614_RS05755	ENOG4108PMQ	Na H antiporter MnhB subunit-related protein
F1614_RS05760	ENOG4105C8S	subunit m
F1614_RS05800	ENOG4105F2Z	3-oxoadipate enol-lactonase
F1614_RS05820	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
F1614_RS05825	ENOG4105EHG	Permease protein
F1614_RS05830	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
F1614_RS05835	ENOG4107TXC	Transcriptional regulator
F1614_RS05840	ENOG4105CSM	endonuclease III
F1614_RS05845	ENOG4105C75	arginyL-tRNA synthetase
F1614_RS05865	ENOG4105DQ4	alcohol dehydrogenase
F1614_RS05870	ENOG4105QUH	Domain of unknown function (DUF2088)
F1614_RS05875	ENOG4105DVM	PP-loop domain protein
F1614_RS05880	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
F1614_RS05885	ENOG4105C8M	UPF0272 protein
F1614_RS05890	ENOG4108XFG	YwhD family
F1614_RS05895	ENOG4105DCI	Phosphohydrolase
F1614_RS05905	ENOG4105CPC	Aldo Keto reductase
F1614_RS05915	ENOG4107QN2	dihydrolipoyl dehydrogenase
F1614_RS05920	ENOG4105QAT	UPF0741 protein
F1614_RS05940	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
F1614_RS05945	ENOG4108IJ2	phosphate acetyltransferase
F1614_RS05950	ENOG4107JTW	chlorite dismutase
F1614_RS05965	ENOG4105CUB	amino acid
F1614_RS05970	ENOG4105M08	Membrane
F1614_RS05980	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
F1614_RS05990	ENOG4105DWF	phosphomethylpyrimidine kinase
F1614_RS06000	ENOG4105CSH	Transporter
F1614_RS06015	ENOG4105CHU	acetyl-coa acetyltransferase
F1614_RS06020	ENOG4107F3J	Amp-dependent synthetase and ligase
F1614_RS06035	ENOG4108VA3	3-hexulose-6-phosphate synthase
F1614_RS06040	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
F1614_RS06050	ENOG4107YEI	lmbE family
F1614_RS06055	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
F1614_RS06065	ENOG4108KUF	arsenical pump membrane protein
F1614_RS06070	ENOG4108UXE	Protein tyrosine phosphatase
F1614_RS06080	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
F1614_RS06080	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
F1614_RS06085	ENOG4107YFT	Nadph-dependent fmn reductase
F1614_RS06090	ENOG410667J	hydrolase
F1614_RS06100	ENOG4108Z6B	deaminase
F1614_RS06110	ENOG4105ZMH	deoxynucleoside kinase
F1614_RS06115	ENOG4105CHR	reductase
F1614_RS06120	ENOG4105CPU	Monooxygenase
F1614_RS06125	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
F1614_RS06130	ENOG4107RZX	Teichoic acid biosynthesis protein
F1614_RS06135	ENOG4105EJJ	Dehydrogenase
F1614_RS06140	ENOG4108QHG	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
F1614_RS06145	ENOG4105CM2	brancheD-chain amino acid aminotransferase
F1614_RS06180	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
F1614_RS06185	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
F1614_RS06195	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
F1614_RS06205	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1614_RS06210	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1614_RS06215	ENOG4107Y49	methyltransferase
F1614_RS06220	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
F1614_RS06225	ENOG4108VZM	50s ribosomal protein L10
F1614_RS06235	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
F1614_RS06240	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
F1614_RS06245	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
F1614_RS06250	ENOG410683Z	Preprotein translocase SecE subunit
F1614_RS06255	ENOG4107FTN	50S ribosomal protein L33
F1614_RS06265	ENOG4105M0M	Tetracycline resistance protein
F1614_RS06270	ENOG4105C2N	RNA methyltransferase TrmH family group 3
F1614_RS06275	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F1614_RS06280	ENOG4105C8N	cysteinyl-tRNA synthetase
F1614_RS06285	ENOG4105D7W	serine acetyltransferase
F1614_RS06290	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
F1614_RS06295	ENOG4105CTP	PilT protein domain protein
F1614_RS06300	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
F1614_RS06305	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
F1614_RS06310	ENOG41066A3	ATP guanido phosphotransferase
F1614_RS06315	ENOG4108Z0C	Uvrb UvrC protein
F1614_RS06320	ENOG4105KEX	transcriptional regulator, ctsr
F1614_RS06325	ENOG4105D9N	nucleoside
F1614_RS06330	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
F1614_RS06335	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
F1614_RS06340	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
F1614_RS06425	ENOG4105CRK	lysyL-tRNA synthetase
F1614_RS06430	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1614_RS06435	ENOG4105KRF	dihydroneopterin aldolase
F1614_RS06440	ENOG4105EEI	dihydropteroate synthase
F1614_RS06445	ENOG4105C6T	cysteine synthase
F1614_RS06450	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
F1614_RS06455	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
F1614_RS06460	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
F1614_RS06465	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
F1614_RS06470	ENOG41060GV	RNA binding s1 domain protein
F1614_RS06480	ENOG41082I2	s4 domain protein
F1614_RS06485	ENOG4108IY2	MazG family
F1614_RS06495	ENOG4108JA2	transcriptioN-repair coupling factor
F1614_RS06500	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
F1614_RS06505	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
F1614_RS06510	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
F1614_RS06515	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
F1614_RS06520	ENOG4105K4W	Could be involved in septation (By similarity)
F1614_RS06525	ENOG4105KME	endoribonuclease L-psp
F1614_RS06530	ENOG4105DFT	pur operon repressor
F1614_RS06535	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
F1614_RS06540	ENOG4105W42	Veg protein
F1614_RS06545	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
F1614_RS06550	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
F1614_RS06555	ENOG4105F8V	Hydrolase, tatD family
F1614_RS06560	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
F1614_RS06565	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
F1614_RS06570	ENOG4105VC4	domain protein
F1614_RS06575	ENOG41060K3	Methyltransferase
F1614_RS06580	ENOG4105QD5	Involved in initiation control of chromosome replication (By similarity)
F1614_RS06585	ENOG4105MA4	psp1 domain protein
F1614_RS06590	ENOG4105FA2	dna polymerase iii
F1614_RS06595	ENOG4105X0R	protein from nitrogen regulatory protein P-II
F1614_RS06600	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
F1614_RS06605	ENOG4105CXN	decarboxylase
F1614_RS06630	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
F1614_RS06635	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
F1614_RS06640	ENOG4105C6E	dna polymerase iii
F1614_RS06660	ENOG4105BZ8	glutamate synthase
F1614_RS06665	ENOG4105CBC	glutamate synthase
F1614_RS06670	ENOG4105C5Q	Transcriptional regulator
F1614_RS06700	ENOG41068JE	domain protein
F1614_RS06705	ENOG4105D01	(LipO)protein
F1614_RS06710	ENOG4108UMI	ABC transporter, permease
F1614_RS06715	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS06720	ENOG4105C28	cystathionine
F1614_RS06735	ENOG4105C8J	)-transporter
F1614_RS06760	ENOG4105GPN	Uncharacterized conserved protein (DUF2294)
F1614_RS06770	ENOG4105EVH	UPF0753 protein
F1614_RS06775	ENOG4108TWJ	NADH dehydrogenase subunit 5
F1614_RS06795	ENOG4105CKI	cobalamin synthesis protein
F1614_RS06850	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
F1614_RS06855	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
F1614_RS06860	ENOG4105C2W	permease
F1614_RS06865	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
F1614_RS06885	ENOG4107R6U	sodium dicarboxylate symporter
F1614_RS06890	ENOG4108DBC	nitroreductase
F1614_RS06900	ENOG4105D3R	alkyl hydroperoxide reductase
F1614_RS06905	ENOG4108JU3	Alkyl hydroperoxide reductase
F1614_RS06930	ENOG4105CVJ	phosphoglycerate mutase
F1614_RS06935	ENOG4105N14	lysine exporter protein LysE YggA
F1614_RS06960	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
F1614_RS06965	ENOG4108UUM	single-stranded DNA-binding protein
F1614_RS06970	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
F1614_RS06985	ENOG4105C3G	gtp-binding protein
F1614_RS06990	ENOG4105VDK	protein, conserved in bacteria
F1614_RS06995	ENOG4105D8X	mechanosensitive ion channel
F1614_RS07000	ENOG4105FA0	parb-like partition protein
F1614_RS07005	ENOG4105C28	cystathionine
F1614_RS07010	ENOG4105C28	cystathionine
F1614_RS07020	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
F1614_RS07030	ENOG4105CHU	acetyl-coa acetyltransferase
F1614_RS07045	ENOG4105VZ8	Transcriptional regulator
F1614_RS07055	ENOG4108IUW	ABC transporter
F1614_RS07085	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
F1614_RS07085	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
F1614_RS07090	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
F1614_RS07095	ENOG4108VA3	3-hexulose-6-phosphate synthase
F1614_RS07115	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
F1614_RS07115	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
F1614_RS07125	ENOG4105C3F	Signal peptidase i
F1614_RS07140	ENOG4105C19	ABC transporter
F1614_RS07165	ENOG4107RBB	ABC transporter, permease
F1614_RS07170	ENOG4105C19	ABC transporter
F1614_RS07205	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
F1614_RS07210	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
F1614_RS07215	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
F1614_RS07220	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
F1614_RS07225	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
F1614_RS07235	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
F1614_RS07240	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
F1614_RS07245	ENOG410848D	S4 domain protein YaaA
F1614_RS07250	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
F1614_RS07255	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1614_RS07260	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
F1614_RS07265	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
F1614_RS07270	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
F1614_RS07275	ENOG4108QYW	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity)
F1614_RS07290	ENOG4105DWV	Homoserine O-trans-acetylase
F1614_RS07300	ENOG4105BZR	domain protein
F1614_RS07305	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
F1614_RS07310	ENOG4105CDU	Replicative dna helicase
F1614_RS07315	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
F1614_RS07335	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
F1614_RS07340	ENOG4105BZU	Histidine kinase
F1614_RS07355	ENOG4105Q2H	domain protein
F1614_RS07360	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
F1614_RS07460	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
F1614_RS07465	ENOG4105C08	Histidine kinase
F1614_RS07475	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
F1614_RS07480	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
F1614_RS07485	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
F1614_RS07515	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
F1614_RS07520	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
F1614_RS07535	ENOG4105EKX	Restriction modification system DNA (Specificity
F1614_RS07540	ENOG4105CVR	type I restriction-modification system
F1614_RS07605	ENOG4105DZR	Type I site-specific deoxyribonuclease
F1614_RS07620	ENOG4107STQ	Multicopper oxidase
F1614_RS07625	ENOG41090UD	(LipO)protein
F1614_RS07630	ENOG4108UXE	Protein tyrosine phosphatase
F1614_RS07650	ENOG41085FC	arsR family transcriptional regulator
F1614_RS07670	ENOG4105BZ1	(ABC) transporter
F1614_RS07690	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1614_RS07695	ENOG4105DA5	(ABC) transporter
F1614_RS07710	ENOG4108WZ2	response regulator
F1614_RS07715	ENOG4105BZU	Histidine kinase
F1614_RS07735	ENOG4105CJ1	ABC, transporter
F1614_RS07750	ENOG4106QP9	(LipO)protein
F1614_RS07755	ENOG4106QP9	(LipO)protein
F1614_RS07765	ENOG4105D8X	mechanosensitive ion channel
F1614_RS07780	ENOG4105F27	Major Facilitator
F1614_RS07785	ENOG4105TRI	Hydrolase
F1614_RS07815	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
F1614_RS07820	ENOG4105DWT	malate dehydrogenase (quinone)
F1614_RS07830	ENOG4108WWS	isoprenylcysteine carboxyl methyltransferase
F1614_RS07845	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
F1614_RS07850	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
F1614_RS07855	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
F1614_RS07860	ENOG4108W8G	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity)
F1614_RS07875	ENOG4107DDB	Cysteine protease able to
F1614_RS07890	ENOG4105CKI	cobalamin synthesis protein
F1614_RS07900	ENOG4107T5J	pyridine nucleotide-disulfide oxidoreductase
F1614_RS07915	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
F1614_RS07925	ENOG4105CHR	reductase
F1614_RS07930	ENOG4108IJ6	ABC transporter
F1614_RS07980	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
F1614_RS07990	ENOG4108RZA	ABC transporter
F1614_RS07995	ENOG4108S9F	abc transporter, atp-binding protein
F1614_RS08005	ENOG4105C6N	Formate acetyltransferase
F1614_RS08010	ENOG4105F1A	Pyruvate formate-lyase
F1614_RS08015	ENOG4107PP3	Acetylornithine deacetylase
F1614_RS08020	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
F1614_RS08025	ENOG4108RZE	Tetr family transcriptional regulator
F1614_RS08035	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
F1614_RS08070	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
F1614_RS08075	ENOG4105C5B	carbamate kinase
F1614_RS08080	ENOG4105DBV	ornithine carbamoyltransferase
F1614_RS08090	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
F1614_RS08095	ENOG4105CUR	5'-nucleotidase, lipoprotein e(p4) family
F1614_RS08100	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
F1614_RS08110	ENOG4105CMT	Dihydroxyacetone kinase
F1614_RS08115	ENOG4108UTZ	Dihydroxyacetone kinase
F1614_RS08120	ENOG4105VDH	Dihydroxyacetone kinase
F1614_RS08130	ENOG4105CZM	Major Facilitator
F1614_RS08135	ENOG4105DDW	LysR family Transcriptional regulator
F1614_RS08170	ENOG4105J1V	Triacylglycerol lipase
F1614_RS08180	ENOG4107QNK	)-transporter
F1614_RS08195	ENOG4105FR1	rard protein
F1614_RS08200	ENOG4107Z6I	Thiamine biosynthesis protein
F1614_RS08205	ENOG4107QPK	)-transporter
F1614_RS08215	ENOG4107RUY	(E1 component), alpha subunit
F1614_RS08225	ENOG4107QKR	Dehydrogenase
F1614_RS08245	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
F1614_RS08250	ENOG4105C72	UPF0176 protein
F1614_RS08255	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
F1614_RS08260	ENOG4108YYC	ycei family
F1614_RS08270	ENOG4105DWT	malate dehydrogenase (quinone)
F1614_RS08280	ENOG4105G7B	Protein of unknown function (DUF2992)
F1614_RS08295	ENOG41071FY	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
F1614_RS08300	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
F1614_RS08305	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
F1614_RS08310	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
F1614_RS08315	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
F1614_RS08320	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
F1614_RS08325	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
F1614_RS08330	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
F1614_RS08335	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
F1614_RS08345	ENOG4105J1V	Triacylglycerol lipase
F1614_RS08355	ENOG4107UVV	polysaccharide deacetylase
F1614_RS08365	ENOG4107QJZ	Glycosyl transferase, family 2
F1614_RS08370	ENOG4108IG5	Transcriptional regulator
F1614_RS08380	ENOG4105F27	Major Facilitator
F1614_RS08385	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
F1614_RS08400	ENOG4105D5T	phosphonate abc transporter
F1614_RS08420	ENOG4106432	Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity)
F1614_RS08425	ENOG4106YAG	Part of the accessory SecA2 SecY2 system specifically required for export of
F1614_RS08430	ENOG4108XJK	accessory Sec system protein Asp1
F1614_RS08435	ENOG41089G2	accessory Sec system protein Asp2
F1614_RS08445	ENOG4108MGR	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity)
F1614_RS08455	ENOG4105EDE	A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity)
F1614_RS08465	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
F1614_RS08475	ENOG4105E5M	Multidrug resistance protein D
F1614_RS08480	ENOG4105EW6	flavin reductase domain protein, FMN-binding
F1614_RS08495	ENOG4108ZHJ	Organic hydroperoxide resistance protein
F1614_RS08505	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
F1614_RS08515	ENOG4105DG6	mannose-6-phosphate isomerase
F1614_RS08520	ENOG4105DM4	PTS System
F1614_RS08525	ENOG4105EMD	TRANSCRIPTIONal
F1614_RS08535	ENOG4105CHR	reductase
F1614_RS08555	ENOG4107PP3	Acetylornithine deacetylase
F1614_RS08560	ENOG4105D4Y	metalloprotease
F1614_RS08565	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
F1614_RS08570	ENOG4105CEU	Arginine dihydrolase
F1614_RS08575	ENOG4105DBV	ornithine carbamoyltransferase
F1614_RS08585	ENOG4105IJS	Transcriptional regulator
F1614_RS08595	ENOG4105PNM	synthesis protein
F1614_RS08605	ENOG4107RA9	decarboxylase
F1614_RS08630	ENOG4105K7W	phage-related replication protein
F1614_RS08640	ENOG4107SJB	teichoic acid biosynthesis
F1614_RS08645	ENOG4105CGD	Nad-dependent epimerase dehydratase
F1614_RS08650	ENOG4105G6Z	alkaline phosphatase
F1614_RS08665	ENOG4105EWM	Histidine kinase
F1614_RS08685	ENOG4107RUZ	Sss sodium solute transporter superfamily
F1614_RS08710	ENOG4105K56	Transcriptional regulator
F1614_RS08730	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
F1614_RS08735	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
F1614_RS08740	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
F1614_RS08745	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
F1614_RS08750	ENOG4108Z73	Siroheme synthase
F1614_RS08755	ENOG410635A	Membrane
F1614_RS08760	ENOG4107RIQ	Sulfate adenylate transferase
F1614_RS08765	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
F1614_RS08775	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
F1614_RS08780	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
F1614_RS08785	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
F1614_RS08795	ENOG4105C94	Transporter
F1614_RS08805	ENOG4105TRT	Transcriptional regulator
F1614_RS08810	ENOG4105C26	Dehydrogenase
F1614_RS08815	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
F1614_RS08835	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
F1614_RS08840	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
F1614_RS08845	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
F1614_RS08850	ENOG4105DWT	malate dehydrogenase (quinone)
F1614_RS08860	ENOG4105WYW	fructose-bisphosphate aldolase
F1614_RS08870	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
F1614_RS08900	ENOG4108JPW	Aminotransferase
F1614_RS08905	ENOG4105CUB	amino acid
F1614_RS08910	ENOG4105CMU	LysR family (Transcriptional regulator
F1614_RS08915	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
F1614_RS08925	ENOG4107FQX	Alpha-acetolactate decarboxylase
F1614_RS08935	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
F1614_RS08940	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
F1614_RS08945	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
F1614_RS08975	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
F1614_RS08980	ENOG4105FGM	Fructosamine kinase
F1614_RS08995	ENOG4105CSR	polyphosphate kinase 2
F1614_RS09005	ENOG4106770	Is able to cleave peptidoglycan (By similarity)
F1614_RS09035	ENOG410681U	heavy metal transport detoxification protein
F1614_RS09040	ENOG4105C59	p-type ATPase
F1614_RS09050	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
F1614_RS09055	ENOG4105C26	Dehydrogenase
F1614_RS09080	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
F1614_RS09085	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
F1614_RS09105	ENOG4105DND	Transcriptional regulator
F1614_RS09110	ENOG4105VAW	lrga family
F1614_RS09115	ENOG41067MG	lrgb family
F1614_RS09125	ENOG4105CI1	PTS System
F1614_RS09140	ENOG4105E2A	Dehydrogenase
F1614_RS09145	ENOG4105XXY	Thioredoxin
F1614_RS09150	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
F1614_RS09165	ENOG4105N98	Capsule biosynthesis protein capB
F1614_RS09175	ENOG4105PNM	synthesis protein
F1614_RS09190	ENOG4105EV1	Ribose uptake protein RbsU
F1614_RS09195	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
F1614_RS09205	ENOG4105CMG	Carbohydrate kinase
F1614_RS09230	ENOG4105EJQ	L-serine dehydratase
F1614_RS09240	ENOG4108Z7F	N-acetyltransferase
F1614_RS09245	ENOG4108Z6X	(sortase) family
F1614_RS09250	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
F1614_RS09260	ENOG4108RCM	Nitroreductase
F1614_RS09270	ENOG4105C26	Dehydrogenase
F1614_RS09280	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
F1614_RS09295	ENOG4105C26	Dehydrogenase
F1614_RS09300	ENOG4108K88	Membrane
F1614_RS09315	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
F1614_RS09320	ENOG4107T5V	SNARE associated Golgi
F1614_RS09325	ENOG4105D06	uba thif-type nad fad binding protein
F1614_RS09330	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
F1614_RS09340	ENOG41080HI	glycine oxidase
F1614_RS09365	ENOG4105NRR	Uncharacterized protein conserved in bacteria (DUF2188)
F1614_RS09390	ENOG4105CXY	transporter
F1614_RS09395	ENOG4105G3Z	GntR family transcriptional regulator
F1614_RS09400	ENOG4105CMG	Carbohydrate kinase
F1614_RS09405	ENOG4105C6Z	Gluconate
F1614_RS09410	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
F1614_RS09415	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
F1614_RS09420	ENOG4107R8N	Glycosyl transferase, family 2
F1614_RS09425	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
F1614_RS09455	ENOG4105EMU	Dehydrogenase
F1614_RS09465	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
F1614_RS09475	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
F1614_RS09485	ENOG4105CN9	Peptidase m42 family protein
F1614_RS09495	ENOG4105CBC	glutamate synthase
F1614_RS09510	ENOG41083J0	(ABC) transporter
F1614_RS09515	ENOG4105C4B	ABC transporter, permease
F1614_RS09520	ENOG4105F27	Major Facilitator
F1614_RS09525	ENOG4105EBR	Carboxylesterase
F1614_RS09530	ENOG4107QTZ	amino acid
F1614_RS09535	ENOG4105CZ9	Domain of unknown function (DU1801)
F1614_RS09560	ENOG4105R40	Glycine betaine carnitine choline
F1614_RS09565	ENOG41067MG	lrgb family
F1614_RS09570	ENOG4105Z9F	murein hydrolase regulator LrgA
F1614_RS09575	ENOG4105DY9	regulatoR
F1614_RS09580	ENOG4108HRK	Histidine kinase
F1614_RS09585	ENOG4105C57	major facilitator superfamily
F1614_RS09590	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
F1614_RS09595	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
F1614_RS09605	ENOG4105C0X	amino acid
F1614_RS09610	ENOG4105C85	amino acid
F1614_RS09615	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
F1614_RS09635	ENOG4105BZW	Glycerate kinase
F1614_RS09655	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
F1614_RS09670	ENOG4105DRP	amino acid AbC transporter
F1614_RS09675	ENOG4105CDA	abc transporter atp-binding protein
F1614_RS09685	ENOG4108RMH	femAB family
F1614_RS09705	ENOG4105TMB	Formate nitrite transporter
F1614_RS09710	ENOG4108XSB	acetyltransferase, (GNAT) family
F1614_RS09720	ENOG4107RRN	ABC transporter substrate-binding protein
F1614_RS09735	ENOG4108IFG	nitrite reductase, (NAD(P)H)
F1614_RS09740	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
F1614_RS09745	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
F1614_RS09755	ENOG4108IUE	nitrate reductase beta subunit
F1614_RS09775	ENOG4105BZU	Histidine kinase
F1614_RS09780	ENOG4105WH1	Two component transcriptional regulator luxr family
F1614_RS09785	ENOG4105DQQ	Major facilitator superfamily MFS_1
F1614_RS09790	ENOG4105K56	Transcriptional regulator
F1614_RS09795	ENOG4108TVJ	Nitroreductase
F1614_RS09815	ENOG410606W	general stress protein
F1614_RS09865	ENOG41090PH	Protease synthase and sporulation negative regulatory protein pai 1
F1614_RS09870	ENOG4107SJB	teichoic acid biosynthesis
F1614_RS09880	ENOG4107SJB	teichoic acid biosynthesis
F1614_RS09895	ENOG4105DWT	malate dehydrogenase (quinone)
F1614_RS09900	ENOG4105BZU	Histidine kinase
F1614_RS09905	ENOG4105EFI	regulatoR
F1614_RS09910	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
F1614_RS09915	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
F1614_RS09930	ENOG4105T65	Membrane-associated protein
F1614_RS09935	ENOG4105C2C	drug resistance transporter, Bcr CflA
F1614_RS09945	ENOG4105CW7	secretion protein, HlyD family
F1614_RS09950	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
F1614_RS09980	ENOG4105D7N	magnesium and cobalt transport protein CorA
F1614_RS09985	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
F1614_RS09990	ENOG4105D6U	Sodium Glutamate Symporter
F1614_RS10010	ENOG4108VX5	3-methyladenine DNA glycosylase
F1614_RS10025	ENOG4105EF1	ribulokinase
F1614_RS10030	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
F1614_RS10040	ENOG4105E66	phosphoriboisomerase A
F1614_RS10055	ENOG4106E7R	Lysostaphin resistance protein A
F1614_RS10060	ENOG41088SP	formiminoglutamate hydrolase
F1614_RS10065	ENOG4105CH2	amidohydrolase
F1614_RS10070	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
F1614_RS10095	ENOG4108PCX	Major Facilitator
F1614_RS10100	ENOG4106PHI	plasmid recombination enzyme
F1614_RS10200	ENOG4105CI1	PTS System
F1614_RS10210	ENOG4107YBY	Hydrolase
F1614_RS10240	ENOG4105C5Y	PTS System
F1614_RS10245	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F1614_RS10260	ENOG4108TYN	CAAX amino terminal protease family protein
F1614_RS10270	ENOG4105ECY	inositol monophosphatase
F1614_RS10275	ENOG4108KGH	TRANSCRIPTIONal
F1614_RS10295	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
F1614_RS10305	ENOG4105C5I	Dehydrogenase
F1614_RS10310	ENOG41080TC	multidrug resistance protein
F1614_RS10315	ENOG4105KPY	Small multidrug resistance protein
F1614_RS10335	ENOG4105DFD	Na H antiporter
F1614_RS10365	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
F1614_RS10370	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
F1614_RS10375	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
F1614_RS10380	ENOG4105HFU	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
F1614_RS10385	ENOG4105CQM	Urea amidohydrolase subunit alpha
F1614_RS10390	ENOG4105KI2	Urea amidohydrolase subunit beta
F1614_RS10395	ENOG4108YZ9	Urea amidohydrolase subunit gamma
F1614_RS10410	ENOG4105FDT	acyl-CoA dehydrogenase
F1614_RS10415	ENOG4105DU0	nucleoside hydrolase
F1614_RS10420	ENOG4107ZYJ	bioY protein
F1614_RS10435	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
F1614_RS10440	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
F1614_RS10445	ENOG4105E0C	molybdate abc transporter
F1614_RS10450	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS10455	ENOG4105D06	uba thif-type nad fad binding protein
F1614_RS10460	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
F1614_RS10465	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1614_RS10470	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
F1614_RS10480	ENOG4108ZAF	Molybdopterin
F1614_RS10490	ENOG41082CS	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
F1614_RS10495	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
F1614_RS10510	ENOG4105C6X	Major Facilitator
F1614_RS10525	ENOG4108TV1	Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity)
F1614_RS10550	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
F1614_RS10555	ENOG4105CSC	Glucose uptake protein
F1614_RS10560	ENOG4105C9U	ATP-dependent DNA helicase RecQ
F1614_RS10565	ENOG4105C7N	Xanthine uracil vitamin C permease
F1614_RS10580	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
F1614_RS10585	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
F1614_RS10590	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
F1614_RS10595	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1614_RS10600	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
F1614_RS10605	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
F1614_RS10610	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
F1614_RS10615	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
F1614_RS10625	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
F1614_RS10630	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
F1614_RS10635	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
F1614_RS10640	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1614_RS10645	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
F1614_RS10650	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
F1614_RS10655	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
F1614_RS10660	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
F1614_RS10665	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
F1614_RS10670	ENOG4105VPB	50S ribosomal protein L30
F1614_RS10675	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
F1614_RS10680	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
F1614_RS10685	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
F1614_RS10690	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
F1614_RS10695	ENOG41067V7	50S ribosomal protein L36
F1614_RS10700	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1614_RS10705	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
F1614_RS10710	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
F1614_RS10715	ENOG4108ZT0	50S ribosomal protein l17
F1614_RS10720	ENOG4108JJB	ABC transporter
F1614_RS10725	ENOG4108JJB	ABC transporter
F1614_RS10735	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
F1614_RS10740	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
F1614_RS10745	ENOG4108UJD	30S ribosomal protein S9
F1614_RS10750	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
F1614_RS10755	ENOG4105E98	transcriptional regulator DeoR family
F1614_RS10760	ENOG4105RSI	Galactose-6-phosphate isomerase subunit LacA
F1614_RS10770	ENOG4106VEM	tagatose-6-phosphate kinase
F1614_RS10775	ENOG4105D2M	Aldolase
F1614_RS10780	ENOG4105VCP	PTS System
F1614_RS10785	ENOG4105CK1	PTS System
F1614_RS10800	ENOG4105DEN	Luciferase family
F1614_RS10805	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
F1614_RS10810	ENOG4105CIS	alcohol dehydrogenase
F1614_RS10825	ENOG4105VBF	alkaline shock protein
F1614_RS10830	ENOG4105DBM	Siderophore biosynthesis protein
F1614_RS10835	ENOG4107SFI	Major Facilitator superfamily
F1614_RS10845	ENOG4106M28	alanine racemase domain protein
F1614_RS10850	ENOG4108HUF	Transporter
F1614_RS10855	ENOG4105DQ5	transport system permease protein
F1614_RS10860	ENOG4108U1V	ABC transporter, permease
F1614_RS10865	ENOG4105DWD	nucleoside recognition domain protein
F1614_RS10870	ENOG4106EQQ	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity)
F1614_RS10875	ENOG4107DUR	UPF0457 protein
F1614_RS10880	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
F1614_RS10885	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
F1614_RS10910	ENOG4105D1F	ATP-binding protein
F1614_RS10960	ENOG4105C8B	TIGR00159 family
F1614_RS10970	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
F1614_RS10975	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
F1614_RS10995	ENOG4105PGM	cation diffusion facilitator family transporter
F1614_RS11015	ENOG4105DG6	mannose-6-phosphate isomerase
F1614_RS11040	ENOG4108RMU	ferritin dps family protein
F1614_RS11045	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
F1614_RS11050	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
F1614_RS11055	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
F1614_RS11060	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
F1614_RS11070	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
F1614_RS11090	ENOG4105HNY	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
F1614_RS11100	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
F1614_RS11105	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
F1614_RS11115	ENOG4105D2N	Aldolase
F1614_RS11120	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
F1614_RS11125	ENOG4105C26	Dehydrogenase
F1614_RS11130	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
F1614_RS11135	ENOG41082DI	50s ribosomal protein l31
F1614_RS11140	ENOG4107104	thymidine kinase
F1614_RS11145	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
F1614_RS11150	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
F1614_RS11160	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
F1614_RS11165	ENOG4107WAU	Protein tyrosine phosphatase
F1614_RS11170	ENOG4108UIC	UPF0340 protein
F1614_RS11175	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
F1614_RS11180	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
F1614_RS11185	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
F1614_RS11195	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
F1614_RS11205	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
F1614_RS11215	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
F1614_RS11220	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
F1614_RS11225	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
F1614_RS11230	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
F1614_RS11240	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
F1614_RS11245	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
F1614_RS11265	ENOG4105JH5	thiaminase II
F1614_RS11275	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
F1614_RS11280	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
F1614_RS11285	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
F1614_RS11295	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
F1614_RS11300	ENOG4105VPX	protein, conserved in bacteria
F1614_RS11320	ENOG4105CPF	Cell wall formation (By similarity)
F1614_RS11325	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
F1614_RS11330	ENOG4105C1J	atp-dependent rna helicase
F1614_RS11340	ENOG4105CKV	Membrane
F1614_RS11345	ENOG410905X	membrane-flanked domain protein
F1614_RS11350	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
F1614_RS11355	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
F1614_RS11365	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
F1614_RS11370	ENOG4107SGM	protein serine threonine phosphatase
F1614_RS11375	ENOG4105WN5	stage II sporulation protein
F1614_RS11380	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
F1614_RS11395	ENOG410906U	SprT-like
F1614_RS11435	ENOG4105C7B	Threonine dehydratase
F1614_RS11440	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
F1614_RS11445	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
F1614_RS11450	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
F1614_RS11460	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
F1614_RS11470	ENOG4105C7K	acetolactate synthase
F1614_RS11475	ENOG4105C01	Dihydroxy-acid dehydratase
F1614_RS11480	ENOG4105K8N	protein family UPF0079, ATPase
F1614_RS11485	ENOG41072GX	Peptidase M22 Glycoprotease
F1614_RS11490	ENOG410801F	ribosomal-protein-alanine acetyltransferase
F1614_RS11495	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
F1614_RS11500	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
F1614_RS11505	ENOG4105C5H	ABC transporter
F1614_RS11510	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
F1614_RS11520	ENOG4105CUC	YeeE YedE family protein
F1614_RS11530	ENOG4105BZU	Histidine kinase
F1614_RS11555	ENOG4108WCX	response regulator
F1614_RS11570	ENOG410695V	Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity)
F1614_RS11580	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
F1614_RS11595	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
F1614_RS11600	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
F1614_RS11620	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
F1614_RS11625	ENOG4105DA5	(ABC) transporter
F1614_RS11635	ENOG4105CJ1	ABC, transporter
F1614_RS11680	ENOG4108FPN	Integrase
F1614_RS11685	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
F1614_RS11725	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
F1614_RS11730	ENOG4105C26	Dehydrogenase
F1614_RS11735	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
F1614_RS11750	ENOG4105CQC	Prephenate dehydratase
F1614_RS11760	ENOG4105DAP	Nicotinate phosphoribosyltransferase
F1614_RS11765	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
F1614_RS11770	ENOG4108U5N	UPF0316 protein
F1614_RS11780	ENOG4105C83	adenylosuccinate lyase
F1614_RS11785	ENOG4105KGF	protein, YerC YecD
F1614_RS11790	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
F1614_RS11795	ENOG4105C4R	Atp-dependent dna helicase
F1614_RS11800	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
F1614_RS11810	ENOG4105CK7	Sodium proline symporter
F1614_RS11815	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
F1614_RS11820	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
F1614_RS11825	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
F1614_RS11830	ENOG4105CBD	Diacylglycerol kinase
F1614_RS11835	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
F1614_RS11845	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
F1614_RS11855	ENOG41090A1	ferritin
F1614_RS11875	ENOG4108V3A	UPF0421 protein
F1614_RS11880	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
F1614_RS11895	ENOG4105ENE	Histidine kinase
F1614_RS11900	ENOG4105WH1	Two component transcriptional regulator luxr family
F1614_RS11905	ENOG4107U9T	Pfam:Ribonuclease_BN
F1614_RS11915	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
F1614_RS11920	ENOG41068PA	UPF0435 protein
F1614_RS11930	ENOG4108S4H	thioesterase Superfamily protein
F1614_RS11945	ENOG4108Z0Z	intracellular protease Pfpi family
F1614_RS11950	ENOG4105BZ4	penicillin-binding protein
F1614_RS11955	ENOG410902V	Modulates RecA activity (By similarity)
F1614_RS11965	ENOG4105EY8	ABC transporter
F1614_RS11975	ENOG41067AE	Membrane-bound metal-dependent hydrolase
F1614_RS11985	ENOG4105EVI	UPF0374 protein
F1614_RS11995	ENOG4107NBY	Membrane
F1614_RS12000	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
F1614_RS12005	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1614_RS12010	ENOG4105C5I	Dehydrogenase
F1614_RS12015	ENOG4105G5W	regulator Fur family
F1614_RS12175	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
F1614_RS12185	ENOG4105E5Q	amino acid AbC transporter
F1614_RS12190	ENOG4105CDA	abc transporter atp-binding protein
F1614_RS12200	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
F1614_RS12230	ENOG4106PHI	plasmid recombination enzyme
F1614_RS12235	ENOG41084HI	prevent-host-death family
F1614_RS12285	ENOG41061M1	UPF0337 protein
F1614_RS12330	ENOG4105CJ1	ABC, transporter
F1614_RS12350	ENOG4105KVH	Transcriptional regulator
F1614_RS12370	ENOG4105K7W	phage-related replication protein
F1614_RS12390	ENOG4108WS4	fmn reductase
F1614_RS12420	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
F1614_RS12425	ENOG4107TJV	N-acetylglutamate semialdehyde dehydrogenase
F1614_RS12430	ENOG4107SBK	Acetylornithine deacetylase
F1614_RS12435	ENOG4108HHA	Transketolase
F1614_RS12440	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
F1614_RS12485	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
F1614_RS12490	ENOG4108URH	decarboxylase
F1614_RS12505	ENOG4107QJE	Chromosome Partitioning Protein