locus-tag	class	description
F1614_RS00020	COG0114	fumarate hydratase activity
F1614_RS00025	COG0564	pseudouridine synthase activity
F1614_RS00030	COG4585	Histidine kinase
F1614_RS00030	COG2203	Gaf domain
F1614_RS00035	COG2197	response regulator
F1614_RS00045	COG4399	Belongs to the UPF0754 family
F1614_RS00050	COG3679	Belongs to the UPF0342 family
F1614_RS00055	COG0420	3'-5' exonuclease activity
F1614_RS00065	COG3481	metal-dependent phosphohydrolase, HD sub domain
F1614_RS00075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1614_RS00090	COG0537	adenosine 5'-monophosphoramidase activity
F1614_RS00095	COG1131	(ABC) transporter
F1614_RS00100	COG4473	ABC transporter
F1614_RS00115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1614_RS00205	COG0318	PFAM AMP-dependent synthetase and ligase
F1614_RS00215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1614_RS00225	COG1506	peptidase
F1614_RS00230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F1614_RS00235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1614_RS00245	COG0656	L-ascorbic acid biosynthetic process
F1614_RS00250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1614_RS00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1614_RS00265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1614_RS00295	COG4193	domain, Protein
F1614_RS00295	COG5632	N-Acetylmuramoyl-L-alanine amidase
F1614_RS00295	COG3266	domain, Protein
F1614_RS00305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1614_RS00305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1614_RS00315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1614_RS00315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1614_RS00320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F1614_RS00325	COG0506	proline dehydrogenase activity
F1614_RS00330	COG2267	carboxylic ester hydrolase activity
F1614_RS00335	COG1846	Transcriptional regulator
F1614_RS00340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F1614_RS00345	COG1242	4 iron, 4 sulfur cluster binding
F1614_RS00350	COG2814	Major facilitator Superfamily
F1614_RS00355	COG0495	leucyl-tRNA aminoacylation
F1614_RS00370	COG2081	HI0933 family
F1614_RS00375	COG2244	polysaccharide biosynthetic process
F1614_RS00380	COG1187	pseudouridine synthase activity
F1614_RS00390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1614_RS00395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1614_RS00400	COG0510	thiamine kinase activity
F1614_RS00405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1614_RS00415	COG1363	Peptidase, m42
F1614_RS00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1614_RS00425	COG4848	Belongs to the UPF0354 family
F1614_RS00430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1614_RS00435	COG1674	ftsk spoiiie
F1614_RS00440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1614_RS00445	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F1614_RS00455	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F1614_RS00455	COG1605	Chorismate mutase
F1614_RS00460	COG1609	Transcriptional regulator
F1614_RS00465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F1614_RS00475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1614_RS00480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1614_RS00485	COG0204	Acyl-transferase
F1614_RS00490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1614_RS00490	COG1263	PTS System
F1614_RS00500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1614_RS00510	COG1764	response to oxidative stress
F1614_RS00515	COG0584	glycerophosphoryl diester phosphodiesterase
F1614_RS00520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1614_RS00530	COG1956	GAF domain-containing protein
F1614_RS00535	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F1614_RS00540	COG1943	Transposase
F1614_RS00550	COG0301	tRNA thio-modification
F1614_RS00560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F1614_RS00565	COG0827	DNA restriction-modification system
F1614_RS00570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1614_RS00575	COG0589	response to stress
F1614_RS00580	COG0686	Belongs to the AlaDH PNT family
F1614_RS00585	COG0006	proline dipeptidase activity
F1614_RS00590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1614_RS00600	COG4109	DRTGG domain
F1614_RS00605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1614_RS00610	COG0587	DNA-directed DNA polymerase activity
F1614_RS00615	COG0281	malic enzyme
F1614_RS00620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1614_RS00625	COG0825	malonyl-CoA metabolic process
F1614_RS00630	COG0205	6-phosphofructokinase activity
F1614_RS00635	COG0469	pyruvate kinase activity
F1614_RS00640	COG1943	Transposase
F1614_RS00645	COG1113	amino acid transport
F1614_RS00650	COG0372	Belongs to the citrate synthase family
F1614_RS00655	COG0538	isocitrate dehydrogenase activity
F1614_RS00660	COG0745	RESPONSE REGULATOR receiver
F1614_RS00665	COG5002	protein histidine kinase activity
F1614_RS00670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1614_RS00670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1614_RS00675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1614_RS00680	COG0237	dephospho-CoA kinase activity
F1614_RS00695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1614_RS00700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1614_RS00705	COG3611	Membrane attachment protein
F1614_RS00710	COG1484	DNA-dependent DNA replication
F1614_RS00715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1614_RS00720	COG0833	amino acid
F1614_RS00725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1614_RS00730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1614_RS00735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1614_RS00740	COG4112	unkown
F1614_RS00750	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1614_RS00755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1614_RS00760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F1614_RS00765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1614_RS00775	COG0181	hydroxymethylbilane synthase activity
F1614_RS00785	COG0113	porphobilinogen synthase activity
F1614_RS00790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1614_RS00800	COG2818	Glycosylase
F1614_RS00805	COG0525	valine-tRNA ligase activity
F1614_RS00810	COG0285	dihydrofolate synthase activity
F1614_RS00820	COG2003	Belongs to the UPF0758 family
F1614_RS00840	COG1792	Involved in formation and maintenance of cell shape
F1614_RS00850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1614_RS00855	COG2868	ribosomal protein
F1614_RS00860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1614_RS00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1614_RS00870	COG4492	Belongs to the UPF0735 family
F1614_RS00875	COG0632	four-way junction helicase activity
F1614_RS00880	COG2255	four-way junction helicase activity
F1614_RS00885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1614_RS00890	COG0343	queuine tRNA-ribosyltransferase activity
F1614_RS00895	COG1862	Preprotein translocase
F1614_RS00900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1614_RS00900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1614_RS00905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F1614_RS00905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F1614_RS00910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1614_RS00920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1614_RS00925	COG1490	D-aminoacyl-tRNA deacylase activity
F1614_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1614_RS00935	COG0124	histidyl-tRNA synthetase
F1614_RS00940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1614_RS00950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F1614_RS00955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F1614_RS00960	COG1959	2 iron, 2 sulfur cluster binding
F1614_RS00970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1614_RS00975	COG1104	cysteine desulfurase activity
F1614_RS00980	COG0482	sulfurtransferase activity
F1614_RS00990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1614_RS00995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1614_RS01000	COG4472	Bacterial protein of unknown function (DUF965)
F1614_RS01005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1614_RS01010	COG3906	Belongs to the UPF0473 family
F1614_RS01030	COG0572	uridine kinase
F1614_RS01035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1614_RS01040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F1614_RS01045	COG1984	allophanate hydrolase subunit 2
F1614_RS01050	COG0511	ligase activity, forming carbon-carbon bonds
F1614_RS01055	COG0439	Biotin carboxylase
F1614_RS01060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F1614_RS01065	COG1914	H( )-stimulated, divalent metal cation uptake system
F1614_RS01070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F1614_RS01075	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F1614_RS01080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F1614_RS01085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1614_RS01090	COG1534	Rna-binding protein
F1614_RS01095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1614_RS01100	COG1713	HD superfamily hydrolase involved in NAD metabolism
F1614_RS01105	COG0799	negative regulation of ribosome biogenesis
F1614_RS01110	COG2226	methyltransferase
F1614_RS01120	COG2131	deaminase
F1614_RS01125	COG2333	competence protein COMEC
F1614_RS01125	COG0658	competence protein
F1614_RS01130	COG1466	dna polymerase III delta subunit
F1614_RS01135	COG0268	Binds directly to 16S ribosomal RNA
F1614_RS01140	COG0481	GTPase activity
F1614_RS01145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1614_RS01150	COG1420	regulation of RNA biosynthetic process
F1614_RS01155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1614_RS01160	COG0443	Heat shock 70 kDa protein
F1614_RS01165	COG0484	heat shock protein binding
F1614_RS01170	COG2264	protein methyltransferase activity
F1614_RS01175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F1614_RS01180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1614_RS01190	COG1030	water channel activity
F1614_RS01195	COG4864	UPF0365 protein
F1614_RS01205	COG1702	phosphate starvation-inducible protein PhoH
F1614_RS01210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1614_RS01215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F1614_RS01220	COG0295	cytidine deaminase activity
F1614_RS01225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F1614_RS01230	COG1381	Involved in DNA repair and RecF pathway recombination
F1614_RS01235	COG0423	glycine-tRNA ligase activity
F1614_RS01240	COG0517	IMP dehydrogenase activity
F1614_RS01245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F1614_RS01250	COG0358	DNA primase activity
F1614_RS01255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1614_RS01260	COG2384	SAM-dependent methyltransferase
F1614_RS01265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F1614_RS01270	COG0513	Belongs to the DEAD box helicase family
F1614_RS01275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F1614_RS01280	COG1121	(ABC) transporter
F1614_RS01285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1614_RS01290	COG0735	belongs to the Fur family
F1614_RS01295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1614_RS01305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1614_RS01310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1614_RS01320	COG4483	Protein conserved in bacteria
F1614_RS01325	COG1940	carbohydrate kinase activity
F1614_RS01330	COG0011	TIGRFAM Protein of
F1614_RS01340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1614_RS01345	COG1459	type II secretion system
F1614_RS01350	COG4537	Required for transformation and DNA binding
F1614_RS01370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1614_RS01375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1614_RS01380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1614_RS01385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1614_RS01395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1614_RS01400	COG0095	Lipoate-protein ligase
F1614_RS01415	COG0006	proline dipeptidase activity
F1614_RS01420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1614_RS01425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1614_RS01430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1614_RS01435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1614_RS01440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1614_RS01445	COG0511	ligase activity, forming carbon-carbon bonds
F1614_RS01450	COG0439	Biotin carboxylase
F1614_RS01455	COG1302	Protein conserved in bacteria
F1614_RS01460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1614_RS01465	COG1570	exodeoxyribonuclease VII activity
F1614_RS01470	COG1722	exodeoxyribonuclease VII activity
F1614_RS01480	COG1438	arginine binding
F1614_RS01485	COG0497	DNA recombination
F1614_RS01490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1614_RS01495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1614_RS01500	COG0022	dehydrogenase e1 component
F1614_RS01505	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1614_RS01515	COG4129	membrane
F1614_RS01525	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1614_RS01530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1614_RS01535	COG0366	Alpha amylase catalytic
F1614_RS01550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1614_RS01555	COG1234	tRNA 3'-trailer cleavage
F1614_RS01560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F1614_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS01570	COG0667	Aldo Keto reductase
F1614_RS01575	COG0494	nUDIX hydrolase
F1614_RS01580	COG0735	belongs to the Fur family
F1614_RS01585	COG4974	Belongs to the 'phage' integrase family
F1614_RS01590	COG1547	Domain of unknown function (DUF309)
F1614_RS01595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F1614_RS01600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1614_RS01605	COG1187	pseudouridine synthase activity
F1614_RS01610	COG0745	RESPONSE REGULATOR receiver
F1614_RS01630	COG1141	Ferredoxin
F1614_RS01640	COG0514	ATP-dependent DNA helicase (RecQ)
F1614_RS01645	COG1388	LysM domain
F1614_RS01650	COG0492	ferredoxin-NADP+ reductase activity
F1614_RS01655	COG0252	asparaginase activity
F1614_RS01660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1614_RS01665	COG0539	negative regulation of cytoplasmic translation
F1614_RS01670	COG1160	GTP binding
F1614_RS01675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1614_RS01690	COG2226	methyltransferase
F1614_RS01700	COG0105	UTP biosynthetic process
F1614_RS01705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1614_RS01710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1614_RS01715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1614_RS01725	COG5582	Belongs to the UPF0302 family
F1614_RS01730	COG4347	Protein of unknown function (DUF1405)
F1614_RS01735	COG2738	Putative neutral zinc metallopeptidase
F1614_RS01740	COG1694	Mazg nucleotide pyrophosphohydrolase
F1614_RS01745	COG0438	transferase activity, transferring glycosyl groups
F1614_RS01750	COG0617	tRNA 3'-terminal CCA addition
F1614_RS01760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F1614_RS01760	COG1199	ATP-dependent helicase activity
F1614_RS01765	COG0017	Asparaginyl-tRNA synthetase
F1614_RS01770	COG3935	DnaD domain protein
F1614_RS01775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1614_RS01785	COG4499	WXG100 protein secretion system (Wss), protein YukC
F1614_RS01785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1614_RS01790	COG3331	DNA recombination
F1614_RS01800	COG4474	Belongs to the UPF0398 family
F1614_RS01805	COG3599	regulation of cell shape
F1614_RS01815	COG0116	Belongs to the methyltransferase superfamily
F1614_RS01825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F1614_RS01830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1614_RS01850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F1614_RS01860	COG1413	lyase activity
F1614_RS01875	COG1136	(ABC) transporter
F1614_RS01895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1614_RS01900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1614_RS01905	COG2190	(PTS) system
F1614_RS01910	COG4479	Belongs to the UPF0346 family
F1614_RS01915	COG0793	Belongs to the peptidase S41A family
F1614_RS01930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1614_RS01935	COG0671	phosphoesterase, PA-phosphatase related
F1614_RS01940	COG3842	ATPase activity
F1614_RS01945	COG4209	transmembrane transport
F1614_RS01955	COG0395	ABC-type sugar transport system, permease component
F1614_RS01965	COG0534	Mate efflux family protein
F1614_RS01970	COG1349	DNA-binding transcription factor activity
F1614_RS01980	COG0745	RESPONSE REGULATOR receiver
F1614_RS01985	COG5002	protein histidine kinase activity
F1614_RS01995	COG0567	Dehydrogenase, E1 component
F1614_RS02000	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1614_RS02020	COG0714	Associated with various cellular activities
F1614_RS02025	COG4548	von Willebrand factor, type A
F1614_RS02030	COG1114	Component of the transport system for branched-chain amino acids
F1614_RS02035	COG3853	Toxic anion resistance protein (TelA)
F1614_RS02045	COG1254	Belongs to the acylphosphatase family
F1614_RS02055	COG1278	Cold shock
F1614_RS02070	COG1131	(ABC) transporter
F1614_RS02090	COG1473	amidohydrolase
F1614_RS02095	COG2171	N-acyltransferase activity
F1614_RS02100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1614_RS02105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1614_RS02110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F1614_RS02115	COG0527	aspartate kinase activity
F1614_RS02120	COG0488	(ABC) transporter
F1614_RS02125	COG2996	Protein conserved in bacteria
F1614_RS02130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F1614_RS02135	COG0573	inorganic phosphate transmembrane transporter activity
F1614_RS02140	COG0581	inorganic phosphate transmembrane transporter activity
F1614_RS02145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1614_RS02150	COG0704	Plays a role in the regulation of phosphate uptake
F1614_RS02155	COG1164	Oligoendopeptidase f
F1614_RS02185	COG4607	ABC-type enterochelin transport system periplasmic component
F1614_RS02195	COG2348	transferase activity, transferring amino-acyl groups
F1614_RS02200	COG2348	transferase activity, transferring amino-acyl groups
F1614_RS02215	COG0159	tryptophan synthase activity
F1614_RS02220	COG0133	tryptophan synthase activity
F1614_RS02225	COG0135	phosphoribosylanthranilate isomerase activity
F1614_RS02230	COG0134	indole-3-glycerol-phosphate synthase activity
F1614_RS02235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1614_RS02240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1614_RS02240	COG0512	Glutamine amidotransferase of anthranilate synthase
F1614_RS02245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1614_RS02250	COG0287	Prephenate dehydrogenase
F1614_RS02255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1614_RS02260	COG1942	4-Oxalocrotonate Tautomerase
F1614_RS02265	COG1316	TRANSCRIPTIONal
F1614_RS02270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1614_RS02275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1614_RS02275	COG0392	lysyltransferase activity
F1614_RS02280	COG0628	permease
F1614_RS02290	COG1115	amino acid carrier protein
F1614_RS02295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1614_RS02300	COG0187	DNA topoisomerase II activity
F1614_RS02305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F1614_RS02310	COG4841	protein insertion into membrane
F1614_RS02315	COG0824	Thioesterase
F1614_RS02320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F1614_RS02325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F1614_RS02330	COG1970	mechanosensitive ion channel activity
F1614_RS02335	COG0419	ATPase involved in DNA repair
F1614_RS02340	COG0420	3'-5' exonuclease activity
F1614_RS02345	COG4846	Membrane protein involved in cytochrome C biogenesis
F1614_RS02355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F1614_RS02360	COG4224	UPF0291 protein
F1614_RS02370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1614_RS02380	COG2340	Cysteine-rich secretory protein family
F1614_RS02385	COG0516	GMP reductase activity
F1614_RS02390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1614_RS02400	COG0753	catalase activity
F1614_RS02405	COG0833	amino acid
F1614_RS02420	COG0083	homoserine kinase activity
F1614_RS02425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1614_RS02430	COG0460	homoserine dehydrogenase
F1614_RS02435	COG0527	aspartate kinase activity
F1614_RS02450	COG1525	nuclease
F1614_RS02465	COG4585	Histidine kinase
F1614_RS02475	COG1131	(ABC) transporter
F1614_RS02480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1614_RS02515	COG0174	glutamine synthetase
F1614_RS02520	COG0789	Transcriptional regulator
F1614_RS02525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F1614_RS02535	COG0386	Belongs to the glutathione peroxidase family
F1614_RS02540	COG1923	regulation of RNA biosynthetic process
F1614_RS02545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1614_RS02555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1614_RS02560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1614_RS02565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F1614_RS02570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
F1614_RS02575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F1614_RS02580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1614_RS02590	COG4550	Control of competence regulator ComK, YlbF/YmcA
F1614_RS02595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1614_RS02605	COG4195	phage-related replication protein
F1614_RS02610	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1614_RS02615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1614_RS02615	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1614_RS02620	COG1692	metallophosphoesterase
F1614_RS02630	COG1418	mRNA catabolic process
F1614_RS02635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1614_RS02640	COG1058	Belongs to the CinA family
F1614_RS02640	COG1546	Belongs to the CinA family
F1614_RS02650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1614_RS02665	COG0300	oxidoreductase activity
F1614_RS02670	COG0612	Peptidase, M16
F1614_RS02675	COG0612	Peptidase, M16
F1614_RS02680	COG2188	Transcriptional regulator
F1614_RS02685	COG1674	ftsk spoiiie
F1614_RS02690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1614_RS02695	COG1185	polyribonucleotide nucleotidyltransferase activity
F1614_RS02700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1614_RS02705	COG0196	riboflavin kinase activity
F1614_RS02710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1614_RS02715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1614_RS02720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1614_RS02725	COG1358	cellular component organization or biogenesis
F1614_RS02730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F1614_RS02735	COG0195	Participates in both transcription termination and antitermination
F1614_RS02740	COG0779	Required for maturation of 30S ribosomal subunits
F1614_RS02745	COG2176	DNA-directed DNA polymerase activity
F1614_RS02750	COG0442	prolyl-tRNA aminoacylation
F1614_RS02760	COG4589	Belongs to the CDS family
F1614_RS02765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1614_RS02770	COG0233	cytoplasmic translational termination
F1614_RS02775	COG0528	UMP kinase activity
F1614_RS02780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1614_RS02785	COG0052	Belongs to the universal ribosomal protein uS2 family
F1614_RS02790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F1614_RS02795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F1614_RS02800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F1614_RS02805	COG4974	Belongs to the 'phage' integrase family
F1614_RS02810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F1614_RS02815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1614_RS02820	COG0758	DNA mediated transformation
F1614_RS02825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F1614_RS02830	COG0045	succinate-CoA ligase (ADP-forming) activity
F1614_RS02835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1614_RS02850	COG4485	Bacterial membrane protein, YfhO
F1614_RS02860	COG0335	large ribosomal subunit rRNA binding
F1614_RS02865	COG0336	Belongs to the RNA methyltransferase TrmD family
F1614_RS02870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1614_RS02875	COG0228	four-way junction DNA binding
F1614_RS02880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1614_RS02885	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F1614_RS02890	COG0552	protein localization to endoplasmic reticulum
F1614_RS02895	COG1196	nuclear chromosome segregation
F1614_RS02900	COG0571	ribonuclease III activity
F1614_RS02905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1614_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS02920	COG0416	fatty acid biosynthetic process
F1614_RS02925	COG1349	DNA-binding transcription factor activity
F1614_RS02930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1614_RS02935	COG1461	Dihydroxyacetone kinase
F1614_RS02940	COG1302	Protein conserved in bacteria
F1614_RS02945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1614_RS02955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1614_RS02960	COG1162	GTPase activity
F1614_RS02970	COG0631	protein serine/threonine phosphatase activity
F1614_RS02975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1614_RS02980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1614_RS02980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F1614_RS02985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1614_RS02990	COG0242	peptide deformylase activity
F1614_RS03000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F1614_RS03005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1614_RS03010	COG1758	RNA polymerase activity
F1614_RS03015	COG0194	GDP metabolic process
F1614_RS03035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1614_RS03040	COG0284	orotidine-5'-phosphate decarboxylase activity
F1614_RS03045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1614_RS03050	COG0505	Belongs to the CarA family
F1614_RS03055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1614_RS03060	COG0540	Belongs to the ATCase OTCase family
F1614_RS03065	COG2233	PERMEase
F1614_RS03070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F1614_RS03075	COG0564	pseudouridine synthase activity
F1614_RS03080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1614_RS03085	COG1388	LysM domain
F1614_RS03085	COG3942	CHAP domain
F1614_RS03095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1614_RS03100	COG3599	regulation of cell shape
F1614_RS03110	COG0762	integral membrane protein
F1614_RS03115	COG1799	cell septum assembly
F1614_RS03120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F1614_RS03130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F1614_RS03135	COG0849	cell division
F1614_RS03140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F1614_RS03145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1614_RS03150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1614_RS03160	COG4839	cell division protein FtsL
F1614_RS03165	COG0275	rRNA processing
F1614_RS03170	COG2001	Belongs to the MraZ family
F1614_RS03175	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
F1614_RS03180	COG0454	-acetyltransferase
F1614_RS03185	COG1011	Hydrolase
F1614_RS03220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1614_RS03225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1614_RS03230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1614_RS03235	COG1053	succinate dehydrogenase
F1614_RS03240	COG2009	succinate dehydrogenase
F1614_RS03245	COG0322	excinuclease ABC activity
F1614_RS03250	COG3118	belongs to the thioredoxin family
F1614_RS03255	COG1193	negative regulation of DNA recombination
F1614_RS03260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1614_RS03260	COG1796	DNA polymerase
F1614_RS03270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F1614_RS03275	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1614_RS03280	COG0072	phenylalanine-tRNA ligase activity
F1614_RS03280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1614_RS03285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1614_RS03290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1614_RS03305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1614_RS03315	COG1323	Belongs to the UPF0348 family
F1614_RS03320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1614_RS03325	COG0742	ribosomal rna small subunit methyltransferase
F1614_RS03335	COG4471	UPF0298 protein
F1614_RS03345	COG0584	glycerophosphoryl diester phosphodiesterase
F1614_RS03350	COG3679	Belongs to the UPF0342 family
F1614_RS03355	COG2340	Cysteine-rich secretory protein family
F1614_RS03365	COG0109	protoheme IX farnesyltransferase activity
F1614_RS03370	COG1612	heme a metabolic process
F1614_RS03375	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F1614_RS03380	COG0772	Belongs to the SEDS family
F1614_RS03385	COG4838	Belongs to the UPF0358 family
F1614_RS03390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1614_RS03395	COG4896	Protein conserved in bacteria
F1614_RS03415	COG0483	inositol monophosphate 1-phosphatase activity
F1614_RS03420	COG4493	Belongs to the UPF0637 family
F1614_RS03425	COG1914	H( )-stimulated, divalent metal cation uptake system
F1614_RS03450	COG1176	ABC-type spermidine putrescine transport system, permease component I
F1614_RS03455	COG3842	ATPase activity
F1614_RS03465	COG4476	Belongs to the UPF0223 family
F1614_RS03475	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1614_RS03480	COG0022	dehydrogenase e1 component
F1614_RS03485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1614_RS03495	COG0242	peptide deformylase activity
F1614_RS03505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1614_RS03510	COG0569	domain protein
F1614_RS03515	COG1294	oxidase, subunit
F1614_RS03530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1614_RS03535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1614_RS03545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F1614_RS03560	COG4716	Myosin-crossreactive antigen
F1614_RS03570	COG4172	Belongs to the ABC transporter superfamily
F1614_RS03575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F1614_RS03580	COG0151	Belongs to the GarS family
F1614_RS03585	COG0138	bifunctional purine biosynthesis protein purh
F1614_RS03590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F1614_RS03595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1614_RS03600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F1614_RS03605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1614_RS03610	COG0047	phosphoribosylformylglycinamidine synthase activity
F1614_RS03615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1614_RS03620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1614_RS03625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F1614_RS03630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F1614_RS03635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1614_RS03645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1614_RS03650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1614_RS03655	COG1845	cytochrome c oxidase, subunit III
F1614_RS03660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F1614_RS03675	COG1316	TRANSCRIPTIONal
F1614_RS03685	COG2153	protein acetylation
F1614_RS03700	COG3594	Acyltransferase
F1614_RS03705	COG0436	Aminotransferase
F1614_RS03710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F1614_RS03720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F1614_RS03725	COG1169	isochorismate synthase
F1614_RS03735	COG1575	Belongs to the MenA family. Type 1 subfamily
F1614_RS03740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1614_RS03750	COG2314	TM2 domain
F1614_RS03795	COG4195	phage-related replication protein
F1614_RS04070	COG4873	Protein conserved in bacteria
F1614_RS04080	COG0737	Belongs to the 5'-nucleotidase family
F1614_RS04085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1614_RS04090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1614_RS04095	COG0861	Integral membrane protein TerC family
F1614_RS04100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F1614_RS04110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1614_RS04115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1614_RS04120	COG2814	Major facilitator Superfamily
F1614_RS04125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F1614_RS04130	COG2382	esterase
F1614_RS04135	COG0628	permease
F1614_RS04250	COG0475	glutathione-regulated potassium exporter activity
F1614_RS04250	COG0569	domain protein
F1614_RS04255	COG2239	Acts as a magnesium transporter
F1614_RS04260	COG0564	pseudouridine synthase activity
F1614_RS04265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1614_RS04270	COG2357	RelA SpoT domain protein
F1614_RS04285	COG2346	COG2346, Truncated hemoglobins
F1614_RS04295	COG1164	Oligoendopeptidase f
F1614_RS04305	COG4862	establishment of competence for transformation
F1614_RS04310	COG1393	Belongs to the ArsC family
F1614_RS04315	COG0180	Tryptophanyl-tRNA synthetase
F1614_RS04320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1614_RS04325	COG0601	transmembrane transport
F1614_RS04330	COG4608	Belongs to the ABC transporter superfamily
F1614_RS04335	COG0444	Belongs to the ABC transporter superfamily
F1614_RS04365	COG0542	response to heat
F1614_RS04380	COG0561	phosphatase activity
F1614_RS04385	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1614_RS04395	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1614_RS04400	COG1074	ATP-dependent DNA helicase activity
F1614_RS04405	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F1614_RS04420	COG0398	Pfam SNARE associated Golgi protein
F1614_RS04425	COG0166	Belongs to the GPI family
F1614_RS04430	COG0137	argininosuccinate synthase activity
F1614_RS04435	COG0165	Argininosuccinate lyase
F1614_RS04440	COG0584	glycerophosphoryl diester phosphodiesterase
F1614_RS04450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1614_RS04460	COG1902	pentaerythritol trinitrate reductase activity
F1614_RS04465	COG1098	S1 RNA binding domain
F1614_RS04470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1614_RS04480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1614_RS04480	COG2111	Na H antiporter
F1614_RS04485	COG2111	Na H antiporter
F1614_RS04490	COG1006	Multisubunit Na H antiporter MnhC subunit
F1614_RS04495	COG0651	ATP synthesis coupled electron transport
F1614_RS04500	COG1863	multisubunit Na H antiporter MnhE subunit
F1614_RS04505	COG2212	antiporter activity
F1614_RS04510	COG1320	monovalent cation:proton antiporter activity
F1614_RS04520	COG2050	protein possibly involved in aromatic compounds catabolism
F1614_RS04525	COG2056	Na+-H+ antiporter family
F1614_RS04530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1614_RS04535	COG1252	NADH dehydrogenase
F1614_RS04540	COG0316	Belongs to the HesB IscA family
F1614_RS04545	COG4844	belongs to the
F1614_RS04550	COG1252	NADH dehydrogenase
F1614_RS04555	COG4837	Protein of unknown function (DUF1462)
F1614_RS04560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F1614_RS04565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F1614_RS04570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1614_RS04575	COG1696	Membrane protein involved in D-alanine export
F1614_RS04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1614_RS04590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1614_RS04595	COG0647	UMP catabolic process
F1614_RS04600	COG2445	Protein of unknown function DUF86
F1614_RS04610	COG4470	Protein conserved in bacteria
F1614_RS04615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1614_RS04620	COG0737	Belongs to the 5'-nucleotidase family
F1614_RS04625	COG0730	response to heat
F1614_RS04630	COG1801	Protein of unknown function DUF72
F1614_RS04635	COG1253	flavin adenine dinucleotide binding
F1614_RS04665	COG0719	Fe-S assembly protein
F1614_RS04670	COG0822	iron-sulfur transferase activity
F1614_RS04675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1614_RS04680	COG0719	Fe-S assembly protein
F1614_RS04685	COG0396	ATPase activity
F1614_RS04695	COG3237	CsbD-like
F1614_RS04705	COG1464	Belongs to the NlpA lipoprotein family
F1614_RS04710	COG2011	ABC-type metal ion transport system permease component
F1614_RS04715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1614_RS04725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F1614_RS04735	COG0509	glycine decarboxylation via glycine cleavage system
F1614_RS04740	COG1393	Belongs to the ArsC family
F1614_RS04745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1614_RS04755	COG0710	3-dehydroquinate dehydratase activity
F1614_RS04760	COG1764	response to oxidative stress
F1614_RS04805	COG4195	phage-related replication protein
F1614_RS04820	COG1278	Cold shock
F1614_RS04860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1614_RS04905	COG5484	DNA packaging
F1614_RS04905	COG3728	DNA packaging
F1614_RS04925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1614_RS04930	COG0557	exoribonuclease II activity
F1614_RS04935	COG1647	Serine aminopeptidase, S33
F1614_RS04940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1614_RS04950	COG0148	phosphopyruvate hydratase activity
F1614_RS04955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F1614_RS04960	COG0149	triose-phosphate isomerase activity
F1614_RS04965	COG0126	phosphoglycerate kinase activity
F1614_RS04970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1614_RS04990	COG1090	epimerase
F1614_RS05000	COG0740	serine-type endopeptidase activity
F1614_RS05010	COG1481	regulation of sporulation
F1614_RS05015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F1614_RS05020	COG1660	Displays ATPase and GTPase activities
F1614_RS05025	COG0492	ferredoxin-NADP+ reductase activity
F1614_RS05040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1614_RS05045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F1614_RS05050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1614_RS05055	COG0556	nucleotide-excision repair
F1614_RS05075	COG1388	LysM domain
F1614_RS05075	COG3942	CHAP domain
F1614_RS05085	COG0653	protein targeting
F1614_RS05090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F1614_RS05095	COG1040	competence protein
F1614_RS05100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F1614_RS05110	COG1739	Uncharacterized protein family UPF0029
F1614_RS05115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1614_RS05120	COG2199	diguanylate cyclase activity
F1614_RS05135	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1614_RS05140	COG1929	Belongs to the glycerate kinase type-1 family
F1614_RS05160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F1614_RS05175	COG4604	ABC transporter, ATP-binding protein
F1614_RS05180	COG4605	iron ion homeostasis
F1614_RS05185	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1614_RS05195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1614_RS05200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1614_RS05205	COG1780	Probably involved in ribonucleotide reductase function
F1614_RS05215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F1614_RS05220	COG3104	oligopeptide transport
F1614_RS05230	COG1597	lipid kinase activity
F1614_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS05235	COG1454	alcohol dehydrogenase
F1614_RS05240	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
F1614_RS05245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1614_RS05255	COG1125	glycine betaine transport
F1614_RS05255	COG0517	IMP dehydrogenase activity
F1614_RS05260	COG0514	ATP-dependent DNA helicase (RecQ)
F1614_RS05265	COG0488	(ABC) transporter
F1614_RS05280	COG1368	sulfuric ester hydrolase activity
F1614_RS05290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F1614_RS05305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1614_RS05315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F1614_RS05320	COG0720	synthase
F1614_RS05325	COG0602	queuosine metabolic process
F1614_RS05345	COG0745	RESPONSE REGULATOR receiver
F1614_RS05350	COG5002	protein histidine kinase activity
F1614_RS05355	COG0463	Glycosyl transferase, family 2
F1614_RS05365	COG0656	L-ascorbic acid biosynthetic process
F1614_RS05370	COG1253	flavin adenine dinucleotide binding
F1614_RS05375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F1614_RS05380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1614_RS05380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1614_RS05380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1614_RS05385	COG1105	Belongs to the carbohydrate kinase PfkB family
F1614_RS05390	COG1349	DNA-binding transcription factor activity
F1614_RS05400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F1614_RS05430	COG0471	metal ion transport
F1614_RS05435	COG0039	L-malate dehydrogenase activity
F1614_RS05455	COG1846	Transcriptional regulator
F1614_RS05460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F1614_RS05465	COG4988	ABC transporter
F1614_RS05470	COG1968	undecaprenyl-diphosphatase activity
F1614_RS05485	COG1671	Belongs to the UPF0178 family
F1614_RS05490	COG1611	Belongs to the LOG family
F1614_RS05515	COG2839	Protein conserved in bacteria
F1614_RS05520	COG2814	Major facilitator Superfamily
F1614_RS05525	COG0583	DNA-binding transcription factor activity
F1614_RS05545	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
F1614_RS05555	COG0217	transcriptional regulatory protein
F1614_RS05575	COG1388	LysM domain
F1614_RS05575	COG3942	CHAP domain
F1614_RS05580	COG0306	phosphate transporter
F1614_RS05585	COG1392	Phosphate transport regulator
F1614_RS05590	COG0577	efflux transmembrane transporter activity
F1614_RS05595	COG1136	(ABC) transporter
F1614_RS05600	COG2205	protein histidine kinase activity
F1614_RS05605	COG0745	RESPONSE REGULATOR receiver
F1614_RS05625	COG3949	Membrane
F1614_RS05635	COG1120	ATPase activity
F1614_RS05640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F1614_RS05650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F1614_RS05655	COG1132	(ABC) transporter
F1614_RS05670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1614_RS05680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1614_RS05685	COG1682	transport, permease protein
F1614_RS05690	COG1134	teichoic acid transport
F1614_RS05695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F1614_RS05705	COG1321	iron dependent repressor
F1614_RS05710	COG1121	(ABC) transporter
F1614_RS05715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1614_RS05720	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1614_RS05730	COG1320	monovalent cation:proton antiporter activity
F1614_RS05735	COG2212	antiporter activity
F1614_RS05740	COG1863	multisubunit Na H antiporter MnhE subunit
F1614_RS05745	COG0651	ATP synthesis coupled electron transport
F1614_RS05750	COG1006	Multisubunit Na H antiporter MnhC subunit
F1614_RS05755	COG2111	Na H antiporter
F1614_RS05760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1614_RS05760	COG2111	Na H antiporter
F1614_RS05800	COG0596	Alpha beta hydrolase
F1614_RS05820	COG0546	phosphoglycolate phosphatase activity
F1614_RS05825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1614_RS05830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1614_RS05835	COG0789	Transcriptional regulator
F1614_RS05840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1614_RS05845	COG0018	arginyl-trna synthetase
F1614_RS05865	COG1064	alcohol dehydrogenase
F1614_RS05870	COG3875	lactate racemase activity
F1614_RS05875	COG1606	tRNA processing
F1614_RS05880	COG1691	(AIR) carboxylase
F1614_RS05885	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
F1614_RS05895	COG1078	dGTPase activity
F1614_RS05905	COG0667	Aldo Keto reductase
F1614_RS05915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1614_RS05920	COG4844	belongs to the
F1614_RS05940	COG0095	Lipoate-protein ligase
F1614_RS05945	COG0280	phosphate acetyltransferase
F1614_RS05965	COG0531	amino acid
F1614_RS05970	COG2363	Small membrane protein
F1614_RS05980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F1614_RS05990	COG0351	phosphomethylpyrimidine kinase
F1614_RS06000	COG0477	Major facilitator Superfamily
F1614_RS06015	COG0183	Belongs to the thiolase family
F1614_RS06020	COG0318	PFAM AMP-dependent synthetase and ligase
F1614_RS06035	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F1614_RS06040	COG0363	glucosamine-6-phosphate deaminase activity
F1614_RS06050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1614_RS06055	COG1469	GTP cyclohydrolase I activity
F1614_RS06065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F1614_RS06070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1614_RS06085	COG0431	NADPH-dependent FMN reductase
F1614_RS06090	COG0561	phosphatase activity
F1614_RS06105	COG1428	Deoxynucleoside kinase
F1614_RS06110	COG1428	Deoxynucleoside kinase
F1614_RS06125	COG0546	phosphoglycolate phosphatase activity
F1614_RS06130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1614_RS06135	COG1063	alcohol dehydrogenase
F1614_RS06140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F1614_RS06145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1614_RS06170	COG1473	amidohydrolase
F1614_RS06180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1614_RS06185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1614_RS06195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1614_RS06205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1614_RS06210	COG0085	RNA polymerase activity
F1614_RS06215	COG2813	Specifically methylates the guanine in position
F1614_RS06220	COG0222	ribosome binding
F1614_RS06225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1614_RS06235	COG0081	regulation of translation
F1614_RS06240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1614_RS06245	COG0250	Participates in transcription elongation, termination and antitermination
F1614_RS06250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1614_RS06255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1614_RS06265	COG3688	RNA-binding protein containing a PIN domain
F1614_RS06270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1614_RS06275	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F1614_RS06280	COG0215	cysteine-tRNA ligase activity
F1614_RS06285	COG1045	serine acetyltransferase
F1614_RS06290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1614_RS06295	COG4956	integral membrane protein (PIN domain superfamily)
F1614_RS06300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F1614_RS06305	COG0542	response to heat
F1614_RS06310	COG3869	Catalyzes the specific phosphorylation of arginine residues in
F1614_RS06315	COG3880	PFAM UvrB UvrC protein
F1614_RS06320	COG4463	regulation of RNA biosynthetic process
F1614_RS06325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F1614_RS06330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F1614_RS06335	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F1614_RS06340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1614_RS06425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1614_RS06430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1614_RS06435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1614_RS06440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1614_RS06445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1614_RS06450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F1614_RS06455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1614_RS06465	COG0037	tRNA processing
F1614_RS06470	COG1098	S1 RNA binding domain
F1614_RS06480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F1614_RS06485	COG3956	TIGRFAM MazG family protein
F1614_RS06490	COG2244	polysaccharide biosynthetic process
F1614_RS06495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F1614_RS06500	COG0193	aminoacyl-tRNA hydrolase activity
F1614_RS06505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1614_RS06510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1614_RS06515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1614_RS06520	COG2088	sporulation resulting in formation of a cellular spore
F1614_RS06525	COG0251	oxidation-reduction process
F1614_RS06530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1614_RS06535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1614_RS06540	COG4466	Protein conserved in bacteria
F1614_RS06545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1614_RS06550	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F1614_RS06555	COG0084	hydrolase, TatD family'
F1614_RS06560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1614_RS06560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1614_RS06565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F1614_RS06570	COG2827	Endonuclease containing a URI domain
F1614_RS06575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F1614_RS06580	COG4467	Involved in initiation control of chromosome replication
F1614_RS06585	COG1774	PSP1 C-terminal conserved region
F1614_RS06590	COG0470	DNA polymerase III
F1614_RS06595	COG3870	Protein conserved in bacteria
F1614_RS06600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1614_RS06605	COG1982	Orn Lys Arg decarboxylase major
F1614_RS06630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1614_RS06635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1614_RS06640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F1614_RS06660	COG0493	'glutamate synthase
F1614_RS06665	COG0067	glutamate synthase
F1614_RS06665	COG0069	glutamate synthase activity
F1614_RS06665	COG0070	glutamate synthase
F1614_RS06670	COG0583	DNA-binding transcription factor activity
F1614_RS06700	COG3942	CHAP domain
F1614_RS06700	COG1388	LysM domain
F1614_RS06710	COG2011	ABC-type metal ion transport system permease component
F1614_RS06715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1614_RS06720	COG0626	cystathionine gamma-synthase activity
F1614_RS06725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1614_RS06735	COG0733	neurotransmitter:sodium symporter activity
F1614_RS06745	COG1647	Serine aminopeptidase, S33
F1614_RS06760	COG5609	conserved protein (DUF2294)
F1614_RS06770	COG3002	Belongs to the UPF0753 family
F1614_RS06775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1614_RS06795	COG0523	cobalamin synthesis protein
F1614_RS06850	COG0519	Catalyzes the synthesis of GMP from XMP
F1614_RS06850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1614_RS06855	COG0517	IMP dehydrogenase activity
F1614_RS06855	COG0516	GMP reductase activity
F1614_RS06860	COG2233	PERMEase
F1614_RS06865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1614_RS06880	COG5183	chlorophyll binding
F1614_RS06885	COG1823	symporter activity
F1614_RS06890	COG0778	Nitroreductase
F1614_RS06900	COG0450	alkyl hydroperoxide reductase
F1614_RS06905	COG3634	alkyl hydroperoxide reductase activity
F1614_RS06935	COG1280	lysine exporter protein (LysE YggA)
F1614_RS06960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1614_RS06970	COG0360	Binds together with S18 to 16S ribosomal RNA
F1614_RS06985	COG0012	GTP binding
F1614_RS06990	COG4481	Protein conserved in bacteria
F1614_RS06995	COG0668	transmembrane transport
F1614_RS07000	COG1475	DNA binding
F1614_RS07005	COG0626	cystathionine gamma-synthase activity
F1614_RS07010	COG0626	cystathionine gamma-synthase activity
F1614_RS07015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F1614_RS07015	COG0646	methionine synthase
F1614_RS07020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1614_RS07030	COG0183	Belongs to the thiolase family
F1614_RS07045	COG1476	TRANSCRIPTIONal
F1614_RS07055	COG4555	ABC transporter
F1614_RS07085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1614_RS07085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1614_RS07090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1614_RS07095	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F1614_RS07140	COG1136	(ABC) transporter
F1614_RS07145	COG0577	efflux transmembrane transporter activity
F1614_RS07165	COG0577	efflux transmembrane transporter activity
F1614_RS07170	COG1136	(ABC) transporter
F1614_RS07205	COG1475	DNA binding
F1614_RS07210	COG0357	Ribosomal RNA small subunit methyltransferase G
F1614_RS07215	COG0445	tRNA wobble uridine modification
F1614_RS07220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1614_RS07225	COG0594	ribonuclease P activity
F1614_RS07235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1614_RS07240	COG0592	DNA-directed DNA polymerase activity
F1614_RS07245	COG2501	S4 domain
F1614_RS07250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F1614_RS07255	COG0187	DNA topoisomerase II activity
F1614_RS07260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1614_RS07265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F1614_RS07270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1614_RS07290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1614_RS07300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
F1614_RS07305	COG0359	binds to the 23S rRNA
F1614_RS07310	COG0305	Participates in initiation and elongation during chromosome replication
F1614_RS07315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1614_RS07335	COG0745	RESPONSE REGULATOR receiver
F1614_RS07340	COG5002	protein histidine kinase activity
F1614_RS07345	COG4863	YycH protein
F1614_RS07355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F1614_RS07360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F1614_RS07460	COG0745	RESPONSE REGULATOR receiver
F1614_RS07465	COG2205	protein histidine kinase activity
F1614_RS07475	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F1614_RS07480	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F1614_RS07535	COG0732	type I restriction modification DNA specificity domain
F1614_RS07540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F1614_RS07605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F1614_RS07615	COG2217	Heavy metal translocating P-type atpase
F1614_RS07620	COG2132	Multicopper oxidase
F1614_RS07625	COG1388	LysM domain
F1614_RS07630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1614_RS07650	COG0640	Transcriptional regulator
F1614_RS07690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1614_RS07695	COG1131	(ABC) transporter
F1614_RS07710	COG0745	RESPONSE REGULATOR receiver
F1614_RS07715	COG5002	protein histidine kinase activity
F1614_RS07735	COG1131	(ABC) transporter
F1614_RS07765	COG0668	transmembrane transport
F1614_RS07780	COG2814	Major facilitator Superfamily
F1614_RS07785	COG0561	phosphatase activity
F1614_RS07815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F1614_RS07820	COG0579	oxidoreductase
F1614_RS07830	COG1755	Isoprenylcysteine carboxyl methyltransferase
F1614_RS07845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F1614_RS07850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1614_RS07860	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
F1614_RS07890	COG0523	cobalamin synthesis protein
F1614_RS07915	COG0431	NADPH-dependent FMN reductase
F1614_RS07915	COG1053	succinate dehydrogenase
F1614_RS07915	COG3976	FMN-binding domain protein
F1614_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS07980	COG0601	transmembrane transport
F1614_RS07990	COG0444	Belongs to the ABC transporter superfamily
F1614_RS07995	COG1124	(ABC) transporter
F1614_RS08005	COG1882	Formate acetyltransferase
F1614_RS08010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F1614_RS08015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1614_RS08020	COG1114	Component of the transport system for branched-chain amino acids
F1614_RS08025	COG1309	transcriptional regulator
F1614_RS08030	COG3246	L-lysine catabolic process to acetate
F1614_RS08035	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1614_RS08070	COG1288	antiporter activity
F1614_RS08075	COG0549	Belongs to the carbamate kinase family
F1614_RS08080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1614_RS08090	COG0346	lactoylglutathione lyase activity
F1614_RS08095	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F1614_RS08100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1614_RS08110	COG2376	Dihydroxyacetone kinase
F1614_RS08115	COG1461	Dihydroxyacetone kinase
F1614_RS08120	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
F1614_RS08130	COG2814	Major facilitator Superfamily
F1614_RS08135	COG0583	DNA-binding transcription factor activity
F1614_RS08145	COG2814	Major facilitator Superfamily
F1614_RS08180	COG2814	Major facilitator Superfamily
F1614_RS08195	COG2962	Rard protein
F1614_RS08200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F1614_RS08205	COG0471	metal ion transport
F1614_RS08210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1614_RS08215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1614_RS08220	COG0022	dehydrogenase e1 component
F1614_RS08225	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1614_RS08245	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F1614_RS08255	COG3386	PFAM SMP-30 Gluconolaconase
F1614_RS08260	COG2353	YceI-like domain
F1614_RS08270	COG0579	oxidoreductase
F1614_RS08295	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F1614_RS08300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1614_RS08305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1614_RS08310	COG0131	Imidazoleglycerol-phosphate dehydratase
F1614_RS08315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1614_RS08320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1614_RS08325	COG0107	imidazoleglycerol-phosphate synthase activity
F1614_RS08330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1614_RS08330	COG0140	phosphoribosyl-ATP diphosphatase activity
F1614_RS08335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
F1614_RS08345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F1614_RS08365	COG1215	transferase activity, transferring glycosyl groups
F1614_RS08380	COG2814	Major facilitator Superfamily
F1614_RS08385	COG0737	Belongs to the 5'-nucleotidase family
F1614_RS08400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F1614_RS08405	COG3639	organic phosphonate transmembrane transporter activity
F1614_RS08425	COG0201	protein transport
F1614_RS08435	COG1073	alpha beta
F1614_RS08445	COG0653	protein targeting
F1614_RS08450	COG0438	transferase activity, transferring glycosyl groups
F1614_RS08475	COG2814	Major facilitator Superfamily
F1614_RS08480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1614_RS08495	COG1764	response to oxidative stress
F1614_RS08505	COG1705	Flagellar rod assembly protein muramidase FlgJ
F1614_RS08505	COG3942	CHAP domain
F1614_RS08515	COG1482	cell wall glycoprotein biosynthetic process
F1614_RS08520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1614_RS08520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1614_RS08520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1614_RS08525	COG3711	transcriptional antiterminator
F1614_RS08525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1614_RS08555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1614_RS08565	COG1438	arginine binding
F1614_RS08570	COG2235	arginine
F1614_RS08575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1614_RS08585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1614_RS08595	COG2843	Capsule synthesis protein
F1614_RS08605	COG3961	Belongs to the TPP enzyme family
F1614_RS08630	COG4195	phage-related replication protein
F1614_RS08640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1614_RS08645	COG0702	epimerase
F1614_RS08650	COG1785	Belongs to the alkaline phosphatase family
F1614_RS08665	COG2205	protein histidine kinase activity
F1614_RS08670	COG1136	(ABC) transporter
F1614_RS08685	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1614_RS08710	COG1846	Transcriptional regulator
F1614_RS08720	COG0386	Belongs to the glutathione peroxidase family
F1614_RS08730	COG0175	sulfate reduction
F1614_RS08735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F1614_RS08740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1614_RS08755	COG0730	response to heat
F1614_RS08760	COG2046	Belongs to the sulfate adenylyltransferase family
F1614_RS08765	COG0529	Catalyzes the synthesis of activated sulfate
F1614_RS08775	COG1328	CTP reductase activity
F1614_RS08780	COG0602	queuosine metabolic process
F1614_RS08785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F1614_RS08805	COG1510	regulation of RNA biosynthetic process
F1614_RS08815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F1614_RS08820	COG1473	amidohydrolase
F1614_RS08835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1614_RS08840	COG0574	Belongs to the PEP-utilizing enzyme family
F1614_RS08840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1614_RS08845	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F1614_RS08850	COG0579	oxidoreductase
F1614_RS08860	COG3588	fructose-bisphosphate aldolase
F1614_RS08870	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1614_RS08905	COG0531	amino acid
F1614_RS08910	COG0583	DNA-binding transcription factor activity
F1614_RS08915	COG0039	L-malate dehydrogenase activity
F1614_RS08920	COG0028	Belongs to the TPP enzyme family
F1614_RS08925	COG3527	Alpha-acetolactate decarboxylase
F1614_RS08935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F1614_RS08940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1614_RS08945	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1614_RS08960	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1614_RS08975	COG0167	dihydroorotate dehydrogenase activity
F1614_RS08985	COG1113	amino acid transport
F1614_RS09005	COG0741	lytic transglycosylase activity
F1614_RS09025	COG0436	Aminotransferase
F1614_RS09035	COG2608	mercury ion transmembrane transporter activity
F1614_RS09040	COG2217	Heavy metal translocating P-type atpase
F1614_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS09080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1614_RS09085	COG3425	synthase
F1614_RS09105	COG0583	DNA-binding transcription factor activity
F1614_RS09110	COG1380	Effector of murein hydrolase LrgA
F1614_RS09115	COG1346	cytolysis
F1614_RS09120	COG0028	Belongs to the TPP enzyme family
F1614_RS09140	COG1063	alcohol dehydrogenase
F1614_RS09145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1614_RS09150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F1614_RS09165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1614_RS09175	COG2843	Capsule synthesis protein
F1614_RS09190	COG4975	Glucose uptake
F1614_RS09195	COG1869	D-ribose catabolic process
F1614_RS09205	COG1070	Carbohydrate kinase
F1614_RS09225	COG1760	l-serine dehydratase
F1614_RS09230	COG1760	l-serine dehydratase
F1614_RS09245	COG3764	Sortase (surface protein transpeptidase)
F1614_RS09260	COG0778	Nitroreductase
F1614_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS09280	COG2514	catechol 2,3-dioxygenase activity
F1614_RS09295	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS09300	COG3949	Membrane
F1614_RS09315	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
F1614_RS09320	COG0586	Pfam SNARE associated Golgi protein
F1614_RS09325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1614_RS09330	COG2022	thiamine diphosphate biosynthetic process
F1614_RS09340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1614_RS09365	COG4876	unkown
F1614_RS09370	COG2357	RelA SpoT domain protein
F1614_RS09385	COG0789	Transcriptional regulator
F1614_RS09390	COG2271	Major facilitator Superfamily
F1614_RS09395	COG1802	Transcriptional regulator
F1614_RS09405	COG2610	gluconate transmembrane transporter activity
F1614_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1614_RS09415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1614_RS09420	COG1215	transferase activity, transferring glycosyl groups
F1614_RS09425	COG0438	transferase activity, transferring glycosyl groups
F1614_RS09455	COG4221	oxidoreductase activity
F1614_RS09460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1614_RS09465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F1614_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS09485	COG1363	Peptidase, m42
F1614_RS09495	COG0069	glutamate synthase activity
F1614_RS09510	COG4619	ABC transporter
F1614_RS09515	COG0390	transport system, permease component
F1614_RS09520	COG2814	Major facilitator Superfamily
F1614_RS09530	COG0531	amino acid
F1614_RS09535	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
F1614_RS09540	COG1063	alcohol dehydrogenase
F1614_RS09560	COG1174	glycine betaine transport
F1614_RS09565	COG1346	cytolysis
F1614_RS09570	COG1380	Effector of murein hydrolase LrgA
F1614_RS09575	COG3279	Response regulator of the LytR AlgR family
F1614_RS09580	COG3275	phosphorelay sensor kinase activity
F1614_RS09590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F1614_RS09595	COG0706	membrane insertase activity
F1614_RS09605	COG0531	amino acid
F1614_RS09610	COG1113	amino acid transport
F1614_RS09615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1614_RS09635	COG1929	Belongs to the glycerate kinase type-1 family
F1614_RS09650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1614_RS09655	COG0588	phosphoglycerate mutase activity
F1614_RS09670	COG0765	amino acid transport
F1614_RS09675	COG1126	abc transporter atp-binding protein
F1614_RS09685	COG2348	transferase activity, transferring amino-acyl groups
F1614_RS09705	COG2116	formate transmembrane transporter activity
F1614_RS09710	COG0454	-acetyltransferase
F1614_RS09720	COG0747	negative chemotaxis
F1614_RS09735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1614_RS09740	COG2146	nitrite reductase [NAD(P)H] activity
F1614_RS09750	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F1614_RS09755	COG1140	nitrate reductase beta subunit
F1614_RS09765	COG2181	nitrate reductase activity
F1614_RS09775	COG4585	Histidine kinase
F1614_RS09780	COG2197	response regulator
F1614_RS09785	COG2223	nitrite transmembrane transporter activity
F1614_RS09790	COG1846	Transcriptional regulator
F1614_RS09795	COG0778	Nitroreductase
F1614_RS09815	COG3871	stress protein (general stress protein 26)
F1614_RS09830	COG1263	PTS System
F1614_RS09830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1614_RS09860	COG0604	alcohol dehydrogenase
F1614_RS09865	COG0456	acetyltransferase
F1614_RS09870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1614_RS09870	COG0463	Glycosyl transferase, family 2
F1614_RS09880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1614_RS09880	COG0463	Glycosyl transferase, family 2
F1614_RS09885	COG1620	l-lactate permease
F1614_RS09895	COG0579	oxidoreductase
F1614_RS09900	COG3850	Histidine kinase
F1614_RS09900	COG5002	protein histidine kinase activity
F1614_RS09905	COG0745	RESPONSE REGULATOR receiver
F1614_RS09910	COG0577	efflux transmembrane transporter activity
F1614_RS09915	COG1136	(ABC) transporter
F1614_RS09930	COG4640	response to antibiotic
F1614_RS09935	COG2814	Major facilitator Superfamily
F1614_RS09945	COG1566	PFAM secretion protein HlyD family protein
F1614_RS09950	COG2814	Major facilitator Superfamily
F1614_RS09965	COG0657	acetylesterase activity
F1614_RS09980	COG0598	Magnesium transport protein CorA
F1614_RS09985	COG1304	FMN binding
F1614_RS09990	COG0786	glutamate:sodium symporter activity
F1614_RS10010	COG2094	Belongs to the DNA glycosylase MPG family
F1614_RS10025	COG1069	ribulokinase activity
F1614_RS10030	COG2017	converts alpha-aldose to the beta-anomer
F1614_RS10035	COG2258	MOSC domain
F1614_RS10040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F1614_RS10055	COG1266	CAAX protease self-immunity
F1614_RS10060	COG0010	Belongs to the arginase family
F1614_RS10065	COG1473	amidohydrolase
F1614_RS10070	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS10075	COG3316	Transposase and inactivated derivatives
F1614_RS10085	COG3316	Transposase and inactivated derivatives
F1614_RS10110	COG3316	Transposase and inactivated derivatives
F1614_RS10170	COG3316	Transposase and inactivated derivatives
F1614_RS10200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1614_RS10200	COG1263	PTS System
F1614_RS10210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1614_RS10230	COG1113	amino acid transport
F1614_RS10240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1614_RS10240	COG1263	PTS System
F1614_RS10245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F1614_RS10260	COG1266	CAAX protease self-immunity
F1614_RS10270	COG0483	inositol monophosphate 1-phosphatase activity
F1614_RS10305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1614_RS10310	COG2076	Multidrug Resistance protein
F1614_RS10315	COG2076	Multidrug Resistance protein
F1614_RS10335	COG1757	Na H antiporter
F1614_RS10365	COG0829	nickel cation binding
F1614_RS10370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F1614_RS10375	COG0830	nickel cation binding
F1614_RS10380	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F1614_RS10385	COG0804	urea catabolic process
F1614_RS10390	COG0832	Belongs to the urease beta subunit family
F1614_RS10395	COG0831	urea catabolic process
F1614_RS10410	COG1960	acyl-CoA dehydrogenase activity
F1614_RS10415	COG1957	nucleoside hydrolase
F1614_RS10420	COG1268	BioY protein
F1614_RS10435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1614_RS10440	COG0725	ABC transporter, periplasmic molybdate-binding protein
F1614_RS10445	COG4149	molybdate abc transporter
F1614_RS10450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F1614_RS10455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1614_RS10460	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1614_RS10465	COG0315	cyclic pyranopterin monophosphate synthase activity
F1614_RS10470	COG0303	'Molybdopterin
F1614_RS10480	COG0314	molybdopterin synthase activity
F1614_RS10490	COG0746	molybdenum cofactor guanylyltransferase activity
F1614_RS10495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1614_RS10510	COG2814	Major facilitator Superfamily
F1614_RS10525	COG2348	transferase activity, transferring amino-acyl groups
F1614_RS10530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1614_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
F1614_RS10555	COG4975	Glucose uptake
F1614_RS10560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1614_RS10560	COG0551	DNA topoisomerase type I activity
F1614_RS10565	COG2252	PERMEase
F1614_RS10580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1614_RS10585	COG0088	Forms part of the polypeptide exit tunnel
F1614_RS10590	COG0089	rRNA binding
F1614_RS10595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1614_RS10600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1614_RS10605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1614_RS10610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1614_RS10615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F1614_RS10625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1614_RS10630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1614_RS10635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1614_RS10640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1614_RS10645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1614_RS10650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1614_RS10655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1614_RS10660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1614_RS10665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1614_RS10670	COG1841	ribosomal large subunit assembly
F1614_RS10675	COG0200	Binds to the 23S rRNA
F1614_RS10680	COG0201	protein transport
F1614_RS10685	COG0563	adenylate kinase activity
F1614_RS10690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1614_RS10695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1614_RS10700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1614_RS10705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1614_RS10710	COG0202	RNA polymerase activity
F1614_RS10715	COG0203	ribosomal protein L17
F1614_RS10720	COG1122	ATPase activity
F1614_RS10725	COG1122	ATPase activity
F1614_RS10735	COG0101	tRNA pseudouridine synthase activity
F1614_RS10740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1614_RS10745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1614_RS10750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1614_RS10755	COG1349	DNA-binding transcription factor activity
F1614_RS10760	COG0698	ribose 5-phosphate isomerase
F1614_RS10765	COG0698	ribose 5-phosphate isomerase
F1614_RS10770	COG1105	Belongs to the carbohydrate kinase PfkB family
F1614_RS10775	COG3684	Belongs to the aldolase LacD family
F1614_RS10780	COG1447	Phosphotransferase system cellobiose-specific component IIA
F1614_RS10785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F1614_RS10785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F1614_RS10800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1614_RS10805	COG2130	NADP-dependent
F1614_RS10810	COG0604	alcohol dehydrogenase
F1614_RS10825	COG1302	Protein conserved in bacteria
F1614_RS10830	COG4264	IucA IucC family
F1614_RS10835	COG2814	Major facilitator Superfamily
F1614_RS10840	COG4264	IucA IucC family
F1614_RS10845	COG3457	Alanine racemase
F1614_RS10850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F1614_RS10855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1614_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1614_RS10870	COG2329	Antibiotic biosynthesis monooxygenase
F1614_RS10880	COG1988	membrane-bound metal-dependent
F1614_RS10885	COG4284	Utp--glucose-1-phosphate uridylyltransferase
F1614_RS10905	COG2814	Major facilitator Superfamily
F1614_RS10910	COG0489	protein tyrosine kinase activity
F1614_RS10960	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F1614_RS10970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1614_RS10975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1614_RS10980	COG0561	phosphatase activity
F1614_RS11000	COG0640	Transcriptional regulator
F1614_RS11005	COG0702	epimerase
F1614_RS11015	COG1482	cell wall glycoprotein biosynthetic process
F1614_RS11040	COG0783	Belongs to the Dps family
F1614_RS11050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F1614_RS11055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F1614_RS11060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F1614_RS11070	COG1854	S-ribosylhomocysteine lyase activity
F1614_RS11090	COG5146	pantothenate kinase activity
F1614_RS11100	COG3343	RNA polymerase activity
F1614_RS11105	COG0504	CTP synthase activity
F1614_RS11115	COG0191	fructose-bisphosphate aldolase activity
F1614_RS11120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1614_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS11130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F1614_RS11135	COG0254	rRNA binding
F1614_RS11140	COG1435	thymidine kinase activity
F1614_RS11145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1614_RS11150	COG2890	protein-(glutamine-N5) methyltransferase activity
F1614_RS11160	COG0009	L-threonylcarbamoyladenylate synthase
F1614_RS11165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1614_RS11170	COG4475	Protein of unknown function (DUF436)
F1614_RS11175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1614_RS11180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F1614_RS11185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F1614_RS11195	COG0356	it plays a direct role in the translocation of protons across the membrane
F1614_RS11205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1614_RS11210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1614_RS11215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1614_RS11220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1614_RS11225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1614_RS11230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1614_RS11240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1614_RS11245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1614_RS11255	COG0629	single-stranded DNA binding
F1614_RS11260	COG1388	LysM domain
F1614_RS11265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F1614_RS11275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F1614_RS11280	COG0352	thiamine-phosphate diphosphorylase activity
F1614_RS11285	COG0706	membrane insertase activity
F1614_RS11290	COG1418	mRNA catabolic process
F1614_RS11295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1614_RS11300	COG1937	Protein conserved in bacteria
F1614_RS11315	COG0772	Belongs to the SEDS family
F1614_RS11320	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1614_RS11325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F1614_RS11330	COG0513	Belongs to the DEAD box helicase family
F1614_RS11340	COG3428	Bacterial PH domain
F1614_RS11345	COG3402	PFAM membrane-flanked domain
F1614_RS11350	COG0736	holo-[acyl-carrier-protein] synthase activity
F1614_RS11355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1614_RS11365	COG2337	Toxic component of a toxin-antitoxin (TA) module
F1614_RS11370	COG2208	phosphoserine phosphatase activity
F1614_RS11385	COG1191	sigma factor activity
F1614_RS11390	COG2183	response to ionizing radiation
F1614_RS11395	COG3091	SprT-like family
F1614_RS11435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F1614_RS11440	COG0066	3-isopropylmalate dehydratase activity
F1614_RS11445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1614_RS11450	COG0473	3-isopropylmalate dehydrogenase activity
F1614_RS11460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1614_RS11470	COG0028	Belongs to the TPP enzyme family
F1614_RS11475	COG0129	dihydroxy-acid dehydratase activity
F1614_RS11480	COG0802	atpase or kinase
F1614_RS11485	COG1214	PFAM Peptidase M22, glycoprotease
F1614_RS11490	COG0456	acetyltransferase
F1614_RS11495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1614_RS11500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1614_RS11505	COG0488	(ABC) transporter
F1614_RS11510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F1614_RS11520	COG2391	methyltransferase activity
F1614_RS11525	COG0425	Belongs to the sulfur carrier protein TusA family
F1614_RS11530	COG0004	ammonium transporteR
F1614_RS11535	COG1609	Transcriptional regulator
F1614_RS11545	COG1621	beta-fructofuranosidase activity
F1614_RS11550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1614_RS11555	COG3279	Response regulator of the LytR AlgR family
F1614_RS11560	COG3290	protein histidine kinase activity
F1614_RS11595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1614_RS11600	COG0459	protein refolding
F1614_RS11620	COG1725	Transcriptional regulator
F1614_RS11635	COG1131	(ABC) transporter
F1614_RS11685	COG4974	Belongs to the 'phage' integrase family
F1614_RS11725	COG2706	6-phosphogluconolactonase activity
F1614_RS11730	COG1012	belongs to the aldehyde dehydrogenase family
F1614_RS11735	COG1227	inorganic diphosphatase activity
F1614_RS11740	COG1335	isochorismatase
F1614_RS11750	COG0077	Prephenate dehydratase
F1614_RS11760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F1614_RS11765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1614_RS11770	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
F1614_RS11780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F1614_RS11785	COG4496	protein, YerC YecD
F1614_RS11790	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
F1614_RS11795	COG0210	DNA helicase
F1614_RS11800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1614_RS11805	COG4851	CamS sex pheromone cAM373 precursor
F1614_RS11810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1614_RS11815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1614_RS11820	COG0154	amidase activity
F1614_RS11825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1614_RS11830	COG1597	lipid kinase activity
F1614_RS11835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1614_RS11845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1614_RS11855	COG1528	Iron-storage protein
F1614_RS11875	COG4129	membrane
F1614_RS11880	COG0024	Methionine aminopeptidase
F1614_RS11895	COG4585	Histidine kinase
F1614_RS11900	COG2197	response regulator
F1614_RS11905	COG1295	ribonuclease BN
F1614_RS11915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1614_RS11920	COG4840	Belongs to the UPF0435 family
F1614_RS11925	COG2309	aminopeptidase activity
F1614_RS11930	COG1607	acyl-coa hydrolase
F1614_RS11935	COG0535	radical SAM domain protein
F1614_RS11945	COG0693	protein deglycase activity
F1614_RS11950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1614_RS11955	COG2137	regulation of response to DNA damage stimulus
F1614_RS11965	COG1134	teichoic acid transport
F1614_RS11965	COG1388	LysM domain
F1614_RS11975	COG1988	membrane-bound metal-dependent
F1614_RS11985	COG3557	Belongs to the UPF0374 family
F1614_RS11995	COG4129	membrane
F1614_RS12000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1614_RS12005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1614_RS12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1614_RS12015	COG0735	belongs to the Fur family
F1614_RS12185	COG0765	amino acid transport
F1614_RS12190	COG1126	abc transporter atp-binding protein
F1614_RS12200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1614_RS12235	COG2161	toxin-antitoxin pair type II binding
F1614_RS12285	COG3237	CsbD-like
F1614_RS12315	COG2311	Membrane
F1614_RS12330	COG1131	(ABC) transporter
F1614_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1614_RS12350	COG1733	regulation of RNA biosynthetic process
F1614_RS12370	COG4195	phage-related replication protein
F1614_RS12390	COG0655	NAD(P)H dehydrogenase (quinone) activity
F1614_RS12420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F1614_RS12425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1614_RS12430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1614_RS12435	COG3959	Transketolase, thiamine diphosphate binding domain
F1614_RS12440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1614_RS12485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1614_RS12490	COG1611	Belongs to the LOG family
F1614_RS12505	COG1192	Involved in chromosome partitioning