locus-tag	class	description
F1616_RS00010	COG0704	Plays a role in the regulation of phosphate uptake
F1616_RS00015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1616_RS00020	COG0581	inorganic phosphate transmembrane transporter activity
F1616_RS00025	COG0573	inorganic phosphate transmembrane transporter activity
F1616_RS00030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F1616_RS00035	COG2996	Protein conserved in bacteria
F1616_RS00040	COG0488	(ABC) transporter
F1616_RS00045	COG0527	aspartate kinase activity
F1616_RS00050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F1616_RS00055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1616_RS00060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1616_RS00065	COG2171	N-acyltransferase activity
F1616_RS00070	COG1473	amidohydrolase
F1616_RS00090	COG1131	(ABC) transporter
F1616_RS00105	COG1278	Cold shock
F1616_RS00115	COG1254	Belongs to the acylphosphatase family
F1616_RS00125	COG3853	Toxic anion resistance protein (TelA)
F1616_RS00130	COG1114	Component of the transport system for branched-chain amino acids
F1616_RS00135	COG4548	von Willebrand factor, type A
F1616_RS00140	COG0714	Associated with various cellular activities
F1616_RS00165	COG0567	Dehydrogenase, E1 component
F1616_RS00175	COG5002	protein histidine kinase activity
F1616_RS00180	COG0745	RESPONSE REGULATOR receiver
F1616_RS00195	COG0671	phosphoesterase, PA-phosphatase related
F1616_RS00200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1616_RS00215	COG0793	Belongs to the peptidase S41A family
F1616_RS00220	COG4479	Belongs to the UPF0346 family
F1616_RS00225	COG2190	(PTS) system
F1616_RS00230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1616_RS00235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1616_RS00255	COG1136	(ABC) transporter
F1616_RS00270	COG1413	lyase activity
F1616_RS00280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F1616_RS00305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F1616_RS00315	COG0116	Belongs to the methyltransferase superfamily
F1616_RS00325	COG3599	regulation of cell shape
F1616_RS00330	COG4474	Belongs to the UPF0398 family
F1616_RS00340	COG3331	DNA recombination
F1616_RS00345	COG4499	WXG100 protein secretion system (Wss), protein YukC
F1616_RS00345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1616_RS00355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1616_RS00360	COG3935	DnaD domain protein
F1616_RS00365	COG0017	Asparaginyl-tRNA synthetase
F1616_RS00370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F1616_RS00370	COG1199	ATP-dependent helicase activity
F1616_RS00375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F1616_RS00375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F1616_RS00380	COG0617	tRNA 3'-terminal CCA addition
F1616_RS00385	COG0438	transferase activity, transferring glycosyl groups
F1616_RS00390	COG1694	Mazg nucleotide pyrophosphohydrolase
F1616_RS00395	COG2738	Putative neutral zinc metallopeptidase
F1616_RS00400	COG4347	Protein of unknown function (DUF1405)
F1616_RS00405	COG5582	Belongs to the UPF0302 family
F1616_RS00415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1616_RS00420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1616_RS00425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1616_RS00430	COG0105	UTP biosynthetic process
F1616_RS00440	COG2226	methyltransferase
F1616_RS00455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1616_RS00460	COG1160	GTP binding
F1616_RS00465	COG0539	negative regulation of cytoplasmic translation
F1616_RS00470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1616_RS00475	COG0252	asparaginase activity
F1616_RS00480	COG0492	ferredoxin-NADP+ reductase activity
F1616_RS00485	COG1388	LysM domain
F1616_RS00490	COG0514	ATP-dependent DNA helicase (RecQ)
F1616_RS00500	COG1141	Ferredoxin
F1616_RS00520	COG0745	RESPONSE REGULATOR receiver
F1616_RS00525	COG1187	pseudouridine synthase activity
F1616_RS00530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1616_RS00535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F1616_RS00540	COG1547	Domain of unknown function (DUF309)
F1616_RS00545	COG4974	Belongs to the 'phage' integrase family
F1616_RS00550	COG0735	belongs to the Fur family
F1616_RS00555	COG0494	nUDIX hydrolase
F1616_RS00560	COG0667	Aldo Keto reductase
F1616_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS00570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F1616_RS00575	COG1234	tRNA 3'-trailer cleavage
F1616_RS00580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1616_RS00595	COG0366	Alpha amylase catalytic
F1616_RS00600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1616_RS00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1616_RS00615	COG4129	membrane
F1616_RS00625	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1616_RS00630	COG0022	dehydrogenase e1 component
F1616_RS00635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1616_RS00640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1616_RS00645	COG0497	DNA recombination
F1616_RS00650	COG1438	arginine binding
F1616_RS00660	COG1722	exodeoxyribonuclease VII activity
F1616_RS00665	COG1570	exodeoxyribonuclease VII activity
F1616_RS00670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1616_RS00675	COG1302	Protein conserved in bacteria
F1616_RS00680	COG0439	Biotin carboxylase
F1616_RS00685	COG0511	ligase activity, forming carbon-carbon bonds
F1616_RS00690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1616_RS00695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1616_RS00700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1616_RS00705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1616_RS00710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1616_RS00715	COG0006	proline dipeptidase activity
F1616_RS00730	COG0095	Lipoate-protein ligase
F1616_RS00735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1616_RS00740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1616_RS00745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1616_RS00750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1616_RS00755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1616_RS00775	COG4537	Required for transformation and DNA binding
F1616_RS00780	COG1459	type II secretion system
F1616_RS00785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1616_RS00795	COG0011	TIGRFAM Protein of
F1616_RS00800	COG1940	carbohydrate kinase activity
F1616_RS00805	COG4483	Protein conserved in bacteria
F1616_RS00815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1616_RS00820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1616_RS00835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1616_RS00840	COG0735	belongs to the Fur family
F1616_RS00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1616_RS00850	COG1121	(ABC) transporter
F1616_RS00855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F1616_RS00860	COG0513	Belongs to the DEAD box helicase family
F1616_RS00865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F1616_RS00870	COG2384	SAM-dependent methyltransferase
F1616_RS00875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1616_RS00880	COG0358	DNA primase activity
F1616_RS00885	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F1616_RS00890	COG0517	IMP dehydrogenase activity
F1616_RS00895	COG0423	glycine-tRNA ligase activity
F1616_RS00900	COG1381	Involved in DNA repair and RecF pathway recombination
F1616_RS00905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F1616_RS00910	COG0295	cytidine deaminase activity
F1616_RS00915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F1616_RS00920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1616_RS00925	COG1702	phosphate starvation-inducible protein PhoH
F1616_RS00935	COG4864	UPF0365 protein
F1616_RS00940	COG1030	water channel activity
F1616_RS00950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1616_RS00955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F1616_RS00960	COG2264	protein methyltransferase activity
F1616_RS00965	COG0484	heat shock protein binding
F1616_RS00970	COG0443	Heat shock 70 kDa protein
F1616_RS00975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1616_RS00980	COG1420	regulation of RNA biosynthetic process
F1616_RS00985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1616_RS00990	COG0481	GTPase activity
F1616_RS00995	COG0268	Binds directly to 16S ribosomal RNA
F1616_RS01000	COG1466	dna polymerase III delta subunit
F1616_RS01005	COG0658	competence protein
F1616_RS01005	COG2333	competence protein COMEC
F1616_RS01010	COG2131	deaminase
F1616_RS01020	COG2226	methyltransferase
F1616_RS01025	COG0799	negative regulation of ribosome biogenesis
F1616_RS01030	COG1713	HD superfamily hydrolase involved in NAD metabolism
F1616_RS01035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1616_RS01040	COG1534	Rna-binding protein
F1616_RS01045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1616_RS01050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F1616_RS01055	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F1616_RS01060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F1616_RS01065	COG1914	H( )-stimulated, divalent metal cation uptake system
F1616_RS01070	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F1616_RS01075	COG0439	Biotin carboxylase
F1616_RS01080	COG0511	ligase activity, forming carbon-carbon bonds
F1616_RS01085	COG1984	allophanate hydrolase subunit 2
F1616_RS01090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F1616_RS01095	COG1943	Transposase
F1616_RS01100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1616_RS01105	COG0572	uridine kinase
F1616_RS01125	COG3906	Belongs to the UPF0473 family
F1616_RS01130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1616_RS01135	COG4472	Bacterial protein of unknown function (DUF965)
F1616_RS01140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1616_RS01145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1616_RS01155	COG0482	sulfurtransferase activity
F1616_RS01160	COG1104	cysteine desulfurase activity
F1616_RS01165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1616_RS01175	COG1959	2 iron, 2 sulfur cluster binding
F1616_RS01180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F1616_RS01185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F1616_RS01195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1616_RS01200	COG0124	histidyl-tRNA synthetase
F1616_RS01205	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1616_RS01210	COG1490	D-aminoacyl-tRNA deacylase activity
F1616_RS01215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1616_RS01225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1616_RS01230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F1616_RS01230	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F1616_RS01235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1616_RS01235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1616_RS01240	COG1862	Preprotein translocase
F1616_RS01245	COG0343	queuine tRNA-ribosyltransferase activity
F1616_RS01250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1616_RS01255	COG2255	four-way junction helicase activity
F1616_RS01260	COG0632	four-way junction helicase activity
F1616_RS01265	COG4492	Belongs to the UPF0735 family
F1616_RS01270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1616_RS01275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1616_RS01280	COG2868	ribosomal protein
F1616_RS01285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1616_RS01295	COG1792	Involved in formation and maintenance of cell shape
F1616_RS01315	COG2003	Belongs to the UPF0758 family
F1616_RS01325	COG0285	dihydrofolate synthase activity
F1616_RS01330	COG0525	valine-tRNA ligase activity
F1616_RS01335	COG2818	Glycosylase
F1616_RS01345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1616_RS01350	COG0113	porphobilinogen synthase activity
F1616_RS01360	COG0181	hydroxymethylbilane synthase activity
F1616_RS01370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1616_RS01375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F1616_RS01380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1616_RS01385	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1616_RS01395	COG4112	unkown
F1616_RS01400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1616_RS01405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1616_RS01410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1616_RS01415	COG0833	amino acid
F1616_RS01420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1616_RS01425	COG1484	DNA-dependent DNA replication
F1616_RS01430	COG3611	Membrane attachment protein
F1616_RS01435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1616_RS01445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1616_RS01460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1616_RS01465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1616_RS01465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1616_RS01470	COG5002	protein histidine kinase activity
F1616_RS01475	COG0745	RESPONSE REGULATOR receiver
F1616_RS01480	COG0538	isocitrate dehydrogenase activity
F1616_RS01485	COG0372	Belongs to the citrate synthase family
F1616_RS01490	COG1113	amino acid transport
F1616_RS01495	COG0469	pyruvate kinase activity
F1616_RS01500	COG0205	6-phosphofructokinase activity
F1616_RS01505	COG0825	malonyl-CoA metabolic process
F1616_RS01510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1616_RS01515	COG0281	malic enzyme
F1616_RS01520	COG0587	DNA-directed DNA polymerase activity
F1616_RS01525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1616_RS01530	COG4109	DRTGG domain
F1616_RS01540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1616_RS01545	COG0006	proline dipeptidase activity
F1616_RS01550	COG0686	Belongs to the AlaDH PNT family
F1616_RS01555	COG0589	response to stress
F1616_RS01565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1616_RS01570	COG0827	DNA restriction-modification system
F1616_RS01575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F1616_RS01585	COG0301	tRNA thio-modification
F1616_RS01595	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F1616_RS01600	COG1956	GAF domain-containing protein
F1616_RS01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1616_RS01615	COG0584	glycerophosphoryl diester phosphodiesterase
F1616_RS01620	COG1764	response to oxidative stress
F1616_RS01625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F1616_RS01630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1616_RS01640	COG1263	PTS System
F1616_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1616_RS01645	COG0204	Acyl-transferase
F1616_RS01650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1616_RS01655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1616_RS01665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F1616_RS01670	COG1609	Transcriptional regulator
F1616_RS01675	COG1605	Chorismate mutase
F1616_RS01675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F1616_RS01685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F1616_RS01690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1616_RS01695	COG1674	ftsk spoiiie
F1616_RS01700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1616_RS01705	COG4848	Belongs to the UPF0354 family
F1616_RS01710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1616_RS01715	COG1363	Peptidase, m42
F1616_RS01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1616_RS01730	COG0510	thiamine kinase activity
F1616_RS01735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1616_RS01740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1616_RS01750	COG1187	pseudouridine synthase activity
F1616_RS01755	COG2244	polysaccharide biosynthetic process
F1616_RS01760	COG2081	HI0933 family
F1616_RS01775	COG0495	leucyl-tRNA aminoacylation
F1616_RS01780	COG2814	Major facilitator Superfamily
F1616_RS01785	COG1242	4 iron, 4 sulfur cluster binding
F1616_RS01790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F1616_RS01795	COG1846	Transcriptional regulator
F1616_RS01800	COG2267	carboxylic ester hydrolase activity
F1616_RS01805	COG0506	proline dehydrogenase activity
F1616_RS01810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F1616_RS01815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1616_RS01815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1616_RS01825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1616_RS01825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1616_RS01835	COG4193	domain, Protein
F1616_RS01835	COG5632	N-Acetylmuramoyl-L-alanine amidase
F1616_RS01835	COG3266	domain, Protein
F1616_RS01865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1616_RS01875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1616_RS01880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1616_RS01895	COG0656	L-ascorbic acid biosynthetic process
F1616_RS01905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1616_RS01910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F1616_RS01915	COG1506	peptidase
F1616_RS01920	COG0494	nUDIX hydrolase
F1616_RS01925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1616_RS01935	COG0318	PFAM AMP-dependent synthetase and ligase
F1616_RS02040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1616_RS02055	COG4473	ABC transporter
F1616_RS02060	COG1131	(ABC) transporter
F1616_RS02065	COG0537	adenosine 5'-monophosphoramidase activity
F1616_RS02080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1616_RS02090	COG3481	metal-dependent phosphohydrolase, HD sub domain
F1616_RS02100	COG0420	3'-5' exonuclease activity
F1616_RS02105	COG3679	Belongs to the UPF0342 family
F1616_RS02110	COG4399	Belongs to the UPF0754 family
F1616_RS02120	COG2197	response regulator
F1616_RS02125	COG2203	Gaf domain
F1616_RS02125	COG4585	Histidine kinase
F1616_RS02130	COG0564	pseudouridine synthase activity
F1616_RS02135	COG0114	fumarate hydratase activity
F1616_RS02160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1616_RS02170	COG1126	abc transporter atp-binding protein
F1616_RS02175	COG0765	amino acid transport
F1616_RS02345	COG0735	belongs to the Fur family
F1616_RS02350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1616_RS02355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1616_RS02360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1616_RS02365	COG4129	membrane
F1616_RS02375	COG3557	Belongs to the UPF0374 family
F1616_RS02385	COG1988	membrane-bound metal-dependent
F1616_RS02395	COG1134	teichoic acid transport
F1616_RS02395	COG1388	LysM domain
F1616_RS02405	COG2137	regulation of response to DNA damage stimulus
F1616_RS02410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1616_RS02415	COG0693	protein deglycase activity
F1616_RS02425	COG0535	radical SAM domain protein
F1616_RS02430	COG1607	acyl-coa hydrolase
F1616_RS02435	COG2309	aminopeptidase activity
F1616_RS02440	COG4840	Belongs to the UPF0435 family
F1616_RS02445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1616_RS02455	COG1295	ribonuclease BN
F1616_RS02460	COG2197	response regulator
F1616_RS02465	COG4585	Histidine kinase
F1616_RS02480	COG0024	Methionine aminopeptidase
F1616_RS02485	COG4129	membrane
F1616_RS02505	COG1528	Iron-storage protein
F1616_RS02515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1616_RS02525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1616_RS02530	COG1597	lipid kinase activity
F1616_RS02535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1616_RS02540	COG0154	amidase activity
F1616_RS02545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1616_RS02550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1616_RS02555	COG4851	CamS sex pheromone cAM373 precursor
F1616_RS02560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1616_RS02565	COG0210	DNA helicase
F1616_RS02570	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
F1616_RS02575	COG4496	protein, YerC YecD
F1616_RS02580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F1616_RS02590	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
F1616_RS02595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1616_RS02600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F1616_RS02610	COG0077	Prephenate dehydratase
F1616_RS02620	COG1335	isochorismatase
F1616_RS02625	COG1227	inorganic diphosphatase activity
F1616_RS02630	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS02635	COG2706	6-phosphogluconolactonase activity
F1616_RS02675	COG4974	Belongs to the 'phage' integrase family
F1616_RS02725	COG1131	(ABC) transporter
F1616_RS02740	COG1725	Transcriptional regulator
F1616_RS02760	COG0459	protein refolding
F1616_RS02765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1616_RS02800	COG3290	protein histidine kinase activity
F1616_RS02805	COG3279	Response regulator of the LytR AlgR family
F1616_RS02810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1616_RS02815	COG1621	beta-fructofuranosidase activity
F1616_RS02825	COG1609	Transcriptional regulator
F1616_RS02830	COG0004	ammonium transporteR
F1616_RS02835	COG0425	Belongs to the sulfur carrier protein TusA family
F1616_RS02840	COG2391	methyltransferase activity
F1616_RS02850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F1616_RS02855	COG0488	(ABC) transporter
F1616_RS02860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1616_RS02865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1616_RS02870	COG0456	acetyltransferase
F1616_RS02875	COG1214	PFAM Peptidase M22, glycoprotease
F1616_RS02880	COG0802	atpase or kinase
F1616_RS02885	COG0129	dihydroxy-acid dehydratase activity
F1616_RS02890	COG0028	Belongs to the TPP enzyme family
F1616_RS02900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1616_RS02905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1616_RS02910	COG0473	3-isopropylmalate dehydrogenase activity
F1616_RS02915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1616_RS02920	COG0066	3-isopropylmalate dehydratase activity
F1616_RS02925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F1616_RS02965	COG3091	SprT-like family
F1616_RS02970	COG2183	response to ionizing radiation
F1616_RS02975	COG1191	sigma factor activity
F1616_RS02990	COG2208	phosphoserine phosphatase activity
F1616_RS02995	COG2337	Toxic component of a toxin-antitoxin (TA) module
F1616_RS03005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1616_RS03010	COG0736	holo-[acyl-carrier-protein] synthase activity
F1616_RS03015	COG3402	PFAM membrane-flanked domain
F1616_RS03020	COG3428	Bacterial PH domain
F1616_RS03030	COG0513	Belongs to the DEAD box helicase family
F1616_RS03035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F1616_RS03040	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1616_RS03045	COG0772	Belongs to the SEDS family
F1616_RS03060	COG1937	Protein conserved in bacteria
F1616_RS03065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1616_RS03070	COG1418	mRNA catabolic process
F1616_RS03075	COG0706	membrane insertase activity
F1616_RS03080	COG0352	thiamine-phosphate diphosphorylase activity
F1616_RS03085	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F1616_RS03095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F1616_RS03100	COG1388	LysM domain
F1616_RS03105	COG0629	single-stranded DNA binding
F1616_RS03115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1616_RS03120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1616_RS03130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1616_RS03135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1616_RS03140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1616_RS03145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1616_RS03150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1616_RS03155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1616_RS03165	COG0356	it plays a direct role in the translocation of protons across the membrane
F1616_RS03175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F1616_RS03180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F1616_RS03185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1616_RS03190	COG4475	Protein of unknown function (DUF436)
F1616_RS03195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1616_RS03200	COG0009	L-threonylcarbamoyladenylate synthase
F1616_RS03210	COG2890	protein-(glutamine-N5) methyltransferase activity
F1616_RS03215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1616_RS03220	COG1435	thymidine kinase activity
F1616_RS03225	COG0254	rRNA binding
F1616_RS03230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F1616_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS03240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1616_RS03245	COG0191	fructose-bisphosphate aldolase activity
F1616_RS03255	COG0504	CTP synthase activity
F1616_RS03260	COG3343	RNA polymerase activity
F1616_RS03270	COG5146	pantothenate kinase activity
F1616_RS03290	COG1854	S-ribosylhomocysteine lyase activity
F1616_RS03300	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F1616_RS03305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F1616_RS03310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F1616_RS03320	COG0783	Belongs to the Dps family
F1616_RS03345	COG1482	cell wall glycoprotein biosynthetic process
F1616_RS03355	COG0702	epimerase
F1616_RS03360	COG0640	Transcriptional regulator
F1616_RS03380	COG0561	phosphatase activity
F1616_RS03385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1616_RS03390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1616_RS03400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F1616_RS03450	COG0489	protein tyrosine kinase activity
F1616_RS03455	COG2814	Major facilitator Superfamily
F1616_RS03480	COG1988	membrane-bound metal-dependent
F1616_RS03490	COG2329	Antibiotic biosynthesis monooxygenase
F1616_RS03500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1616_RS03505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1616_RS03510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F1616_RS03515	COG3457	Alanine racemase
F1616_RS03520	COG4264	IucA IucC family
F1616_RS03525	COG2814	Major facilitator Superfamily
F1616_RS03530	COG4264	IucA IucC family
F1616_RS03535	COG1302	Protein conserved in bacteria
F1616_RS03550	COG0604	alcohol dehydrogenase
F1616_RS03555	COG2130	NADP-dependent
F1616_RS03560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1616_RS03570	COG2723	6-phospho-beta-galactosidase activity
F1616_RS03605	COG5484	DNA packaging
F1616_RS03605	COG3728	DNA packaging
F1616_RS03680	COG0582	viral genome integration into host DNA
F1616_RS03690	COG1447	Phosphotransferase system cellobiose-specific component IIA
F1616_RS03695	COG3684	Belongs to the aldolase LacD family
F1616_RS03700	COG1105	Belongs to the carbohydrate kinase PfkB family
F1616_RS03705	COG0698	ribose 5-phosphate isomerase
F1616_RS03710	COG0698	ribose 5-phosphate isomerase
F1616_RS03715	COG1349	DNA-binding transcription factor activity
F1616_RS03720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1616_RS03725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1616_RS03730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1616_RS03735	COG0101	tRNA pseudouridine synthase activity
F1616_RS03745	COG1122	ATPase activity
F1616_RS03750	COG1122	ATPase activity
F1616_RS03755	COG0203	ribosomal protein L17
F1616_RS03760	COG0202	RNA polymerase activity
F1616_RS03765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1616_RS03770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1616_RS03775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1616_RS03780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1616_RS03785	COG0563	adenylate kinase activity
F1616_RS03790	COG0201	protein transport
F1616_RS03795	COG0200	Binds to the 23S rRNA
F1616_RS03800	COG1841	ribosomal large subunit assembly
F1616_RS03805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1616_RS03810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1616_RS03815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1616_RS03820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1616_RS03825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1616_RS03830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1616_RS03835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1616_RS03840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1616_RS03845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1616_RS03855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F1616_RS03860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1616_RS03865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1616_RS03870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1616_RS03875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1616_RS03880	COG0089	rRNA binding
F1616_RS03885	COG0088	Forms part of the polypeptide exit tunnel
F1616_RS03890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1616_RS03905	COG2252	PERMEase
F1616_RS03910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1616_RS03910	COG0551	DNA topoisomerase type I activity
F1616_RS03915	COG4975	Glucose uptake
F1616_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS03940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1616_RS03945	COG2348	transferase activity, transferring amino-acyl groups
F1616_RS03985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1616_RS03990	COG0746	molybdenum cofactor guanylyltransferase activity
F1616_RS04000	COG0314	molybdopterin synthase activity
F1616_RS04010	COG0303	'Molybdopterin
F1616_RS04015	COG0315	cyclic pyranopterin monophosphate synthase activity
F1616_RS04020	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1616_RS04025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1616_RS04030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F1616_RS04035	COG4149	molybdate abc transporter
F1616_RS04040	COG0725	ABC transporter, periplasmic molybdate-binding protein
F1616_RS04050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1616_RS04060	COG1268	BioY protein
F1616_RS04065	COG1957	nucleoside hydrolase
F1616_RS04070	COG1960	acyl-CoA dehydrogenase activity
F1616_RS04085	COG0831	urea catabolic process
F1616_RS04090	COG0832	Belongs to the urease beta subunit family
F1616_RS04095	COG0804	urea catabolic process
F1616_RS04100	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F1616_RS04105	COG0830	nickel cation binding
F1616_RS04110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F1616_RS04115	COG0829	nickel cation binding
F1616_RS04145	COG1757	Na H antiporter
F1616_RS04165	COG2076	Multidrug Resistance protein
F1616_RS04170	COG2076	Multidrug Resistance protein
F1616_RS04175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1616_RS04200	COG0483	inositol monophosphate 1-phosphatase activity
F1616_RS04205	COG2378	regulation of single-species biofilm formation
F1616_RS04210	COG1266	CAAX protease self-immunity
F1616_RS04225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F1616_RS04230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1616_RS04230	COG1263	PTS System
F1616_RS04240	COG1113	amino acid transport
F1616_RS04260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1616_RS04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1616_RS04270	COG1263	PTS System
F1616_RS04275	COG1737	Transcriptional regulator
F1616_RS04305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1616_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS04315	COG1473	amidohydrolase
F1616_RS04320	COG0010	Belongs to the arginase family
F1616_RS04325	COG1266	CAAX protease self-immunity
F1616_RS04340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F1616_RS04345	COG2258	MOSC domain
F1616_RS04350	COG2017	converts alpha-aldose to the beta-anomer
F1616_RS04355	COG1069	ribulokinase activity
F1616_RS04380	COG2094	Belongs to the DNA glycosylase MPG family
F1616_RS04400	COG0786	glutamate:sodium symporter activity
F1616_RS04405	COG1304	FMN binding
F1616_RS04410	COG0598	Magnesium transport protein CorA
F1616_RS04425	COG0657	acetylesterase activity
F1616_RS04440	COG2814	Major facilitator Superfamily
F1616_RS04445	COG1566	PFAM secretion protein HlyD family protein
F1616_RS04455	COG2814	Major facilitator Superfamily
F1616_RS04460	COG4640	response to antibiotic
F1616_RS04475	COG1136	(ABC) transporter
F1616_RS04480	COG0577	efflux transmembrane transporter activity
F1616_RS04485	COG0745	RESPONSE REGULATOR receiver
F1616_RS04490	COG3850	Histidine kinase
F1616_RS04490	COG5002	protein histidine kinase activity
F1616_RS04495	COG0579	oxidoreductase
F1616_RS04500	COG0438	transferase activity, transferring glycosyl groups
F1616_RS04505	COG1620	l-lactate permease
F1616_RS04510	COG0463	Glycosyl transferase, family 2
F1616_RS04510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1616_RS04520	COG0463	Glycosyl transferase, family 2
F1616_RS04520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1616_RS04525	COG0456	acetyltransferase
F1616_RS04530	COG0604	alcohol dehydrogenase
F1616_RS04565	COG1263	PTS System
F1616_RS04565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1616_RS04580	COG3871	stress protein (general stress protein 26)
F1616_RS04600	COG0778	Nitroreductase
F1616_RS04605	COG1846	Transcriptional regulator
F1616_RS04610	COG2223	nitrite transmembrane transporter activity
F1616_RS04615	COG2197	response regulator
F1616_RS04620	COG4585	Histidine kinase
F1616_RS04630	COG2181	nitrate reductase activity
F1616_RS04640	COG1140	nitrate reductase beta subunit
F1616_RS04645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F1616_RS04655	COG2146	nitrite reductase [NAD(P)H] activity
F1616_RS04660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1616_RS04675	COG0747	negative chemotaxis
F1616_RS04685	COG0454	-acetyltransferase
F1616_RS04690	COG2116	formate transmembrane transporter activity
F1616_RS04710	COG2348	transferase activity, transferring amino-acyl groups
F1616_RS04720	COG1126	abc transporter atp-binding protein
F1616_RS04725	COG0765	amino acid transport
F1616_RS04730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1616_RS04740	COG0588	phosphoglycerate mutase activity
F1616_RS04745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1616_RS04760	COG1929	Belongs to the glycerate kinase type-1 family
F1616_RS04785	COG1113	amino acid transport
F1616_RS04790	COG0531	amino acid
F1616_RS04800	COG0706	membrane insertase activity
F1616_RS04805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F1616_RS04815	COG3275	phosphorelay sensor kinase activity
F1616_RS04820	COG3279	Response regulator of the LytR AlgR family
F1616_RS04825	COG1380	Effector of murein hydrolase LrgA
F1616_RS04830	COG1346	cytolysis
F1616_RS04835	COG1174	glycine betaine transport
F1616_RS04855	COG1063	alcohol dehydrogenase
F1616_RS04865	COG0531	amino acid
F1616_RS04870	COG2272	Belongs to the type-B carboxylesterase lipase family
F1616_RS04875	COG2814	Major facilitator Superfamily
F1616_RS04880	COG0390	transport system, permease component
F1616_RS04885	COG4619	ABC transporter
F1616_RS04900	COG0069	glutamate synthase activity
F1616_RS04910	COG1363	Peptidase, m42
F1616_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS04930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F1616_RS04935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1616_RS04940	COG4221	oxidoreductase activity
F1616_RS04955	COG0556	nucleotide-excision repair
F1616_RS04960	COG0494	nUDIX hydrolase
F1616_RS04970	COG3316	Transposase and inactivated derivatives
F1616_RS04990	COG3316	Transposase and inactivated derivatives
F1616_RS05005	COG1388	LysM domain
F1616_RS05005	COG3942	CHAP domain
F1616_RS05010	COG0306	phosphate transporter
F1616_RS05015	COG1392	Phosphate transport regulator
F1616_RS05020	COG0577	efflux transmembrane transporter activity
F1616_RS05025	COG1136	(ABC) transporter
F1616_RS05030	COG2205	protein histidine kinase activity
F1616_RS05035	COG0745	RESPONSE REGULATOR receiver
F1616_RS05055	COG3949	Membrane
F1616_RS05065	COG1120	ATPase activity
F1616_RS05070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F1616_RS05080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F1616_RS05085	COG1132	(ABC) transporter
F1616_RS05100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1616_RS05110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1616_RS05115	COG1682	transport, permease protein
F1616_RS05120	COG1134	teichoic acid transport
F1616_RS05125	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F1616_RS05135	COG1321	iron dependent repressor
F1616_RS05140	COG1121	(ABC) transporter
F1616_RS05145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1616_RS05150	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1616_RS05160	COG1320	monovalent cation:proton antiporter activity
F1616_RS05165	COG2212	antiporter activity
F1616_RS05170	COG1863	multisubunit Na H antiporter MnhE subunit
F1616_RS05175	COG0651	ATP synthesis coupled electron transport
F1616_RS05180	COG1006	Multisubunit Na H antiporter MnhC subunit
F1616_RS05185	COG2111	Na H antiporter
F1616_RS05190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1616_RS05190	COG2111	Na H antiporter
F1616_RS05230	COG0596	Alpha beta hydrolase
F1616_RS05250	COG0546	phosphoglycolate phosphatase activity
F1616_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1616_RS05260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1616_RS05265	COG0789	Transcriptional regulator
F1616_RS05270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1616_RS05275	COG0018	arginyl-trna synthetase
F1616_RS05300	COG1064	alcohol dehydrogenase
F1616_RS05305	COG3875	lactate racemase activity
F1616_RS05310	COG1606	tRNA processing
F1616_RS05315	COG1691	(AIR) carboxylase
F1616_RS05320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
F1616_RS05330	COG1078	dGTPase activity
F1616_RS05340	COG0667	Aldo Keto reductase
F1616_RS05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1616_RS05355	COG4844	belongs to the
F1616_RS05375	COG0095	Lipoate-protein ligase
F1616_RS05380	COG0280	phosphate acetyltransferase
F1616_RS05405	COG0531	amino acid
F1616_RS05410	COG2363	Small membrane protein
F1616_RS05420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F1616_RS05430	COG0351	phosphomethylpyrimidine kinase
F1616_RS05450	COG0183	Belongs to the thiolase family
F1616_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
F1616_RS05465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F1616_RS05470	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F1616_RS05475	COG0363	glucosamine-6-phosphate deaminase activity
F1616_RS05485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1616_RS05490	COG1469	GTP cyclohydrolase I activity
F1616_RS05500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F1616_RS05505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F1616_RS05510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1616_RS05525	COG0431	NADPH-dependent FMN reductase
F1616_RS05530	COG0561	phosphatase activity
F1616_RS05545	COG1428	Deoxynucleoside kinase
F1616_RS05550	COG1428	Deoxynucleoside kinase
F1616_RS05565	COG0546	phosphoglycolate phosphatase activity
F1616_RS05570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1616_RS05575	COG1063	alcohol dehydrogenase
F1616_RS05580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F1616_RS05585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1616_RS05590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1616_RS05610	COG1473	amidohydrolase
F1616_RS05615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1616_RS05620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1616_RS05630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1616_RS05640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1616_RS05645	COG0085	RNA polymerase activity
F1616_RS05650	COG2813	Specifically methylates the guanine in position
F1616_RS05655	COG0222	ribosome binding
F1616_RS05660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1616_RS05670	COG0081	regulation of translation
F1616_RS05675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1616_RS05680	COG0250	Participates in transcription elongation, termination and antitermination
F1616_RS05685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1616_RS05690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1616_RS05700	COG3688	RNA-binding protein containing a PIN domain
F1616_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1616_RS05710	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F1616_RS05715	COG0215	cysteine-tRNA ligase activity
F1616_RS05720	COG1045	serine acetyltransferase
F1616_RS05725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1616_RS05730	COG4956	integral membrane protein (PIN domain superfamily)
F1616_RS05735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F1616_RS05740	COG0542	response to heat
F1616_RS05745	COG3869	Catalyzes the specific phosphorylation of arginine residues in
F1616_RS05750	COG3880	PFAM UvrB UvrC protein
F1616_RS05755	COG4463	regulation of RNA biosynthetic process
F1616_RS05760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F1616_RS05770	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F1616_RS05775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F1616_RS05780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1616_RS05865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1616_RS05870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1616_RS05875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1616_RS05880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1616_RS05885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1616_RS05890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F1616_RS05895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1616_RS05905	COG0037	tRNA processing
F1616_RS05910	COG1098	S1 RNA binding domain
F1616_RS05920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F1616_RS05925	COG3956	TIGRFAM MazG family protein
F1616_RS05930	COG2244	polysaccharide biosynthetic process
F1616_RS05935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F1616_RS05940	COG0193	aminoacyl-tRNA hydrolase activity
F1616_RS05945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1616_RS05950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1616_RS05955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1616_RS05960	COG2088	sporulation resulting in formation of a cellular spore
F1616_RS05965	COG0251	oxidation-reduction process
F1616_RS05970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1616_RS05975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1616_RS05980	COG4466	Protein conserved in bacteria
F1616_RS05985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1616_RS05990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F1616_RS05995	COG0084	hydrolase, TatD family'
F1616_RS06000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1616_RS06000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1616_RS06005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F1616_RS06010	COG2827	Endonuclease containing a URI domain
F1616_RS06015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F1616_RS06020	COG4467	Involved in initiation control of chromosome replication
F1616_RS06025	COG1774	PSP1 C-terminal conserved region
F1616_RS06030	COG0470	DNA polymerase III
F1616_RS06035	COG3870	Protein conserved in bacteria
F1616_RS06040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1616_RS06045	COG1982	Orn Lys Arg decarboxylase major
F1616_RS06070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1616_RS06075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1616_RS06080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F1616_RS06095	COG2855	membrane
F1616_RS06100	COG0583	DNA-binding transcription factor activity
F1616_RS06110	COG0493	'glutamate synthase
F1616_RS06115	COG0070	glutamate synthase
F1616_RS06115	COG0067	glutamate synthase
F1616_RS06115	COG0069	glutamate synthase activity
F1616_RS06120	COG0583	DNA-binding transcription factor activity
F1616_RS06145	COG0438	transferase activity, transferring glycosyl groups
F1616_RS06150	COG3942	CHAP domain
F1616_RS06150	COG1388	LysM domain
F1616_RS06160	COG2011	ABC-type metal ion transport system permease component
F1616_RS06165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1616_RS06170	COG0626	cystathionine gamma-synthase activity
F1616_RS06175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1616_RS06185	COG0733	neurotransmitter:sodium symporter activity
F1616_RS06195	COG1647	Serine aminopeptidase, S33
F1616_RS06210	COG5609	conserved protein (DUF2294)
F1616_RS06220	COG3002	Belongs to the UPF0753 family
F1616_RS06225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1616_RS06245	COG0523	cobalamin synthesis protein
F1616_RS06260	COG0655	NAD(P)H dehydrogenase (quinone) activity
F1616_RS06300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1616_RS06300	COG0519	Catalyzes the synthesis of GMP from XMP
F1616_RS06305	COG0516	GMP reductase activity
F1616_RS06305	COG0517	IMP dehydrogenase activity
F1616_RS06310	COG2233	PERMEase
F1616_RS06315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1616_RS06330	COG5183	chlorophyll binding
F1616_RS06335	COG1823	symporter activity
F1616_RS06340	COG0778	Nitroreductase
F1616_RS06350	COG0450	alkyl hydroperoxide reductase
F1616_RS06355	COG3634	alkyl hydroperoxide reductase activity
F1616_RS06385	COG1280	lysine exporter protein (LysE YggA)
F1616_RS06410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1616_RS06420	COG0360	Binds together with S18 to 16S ribosomal RNA
F1616_RS06435	COG0012	GTP binding
F1616_RS06440	COG4481	Protein conserved in bacteria
F1616_RS06445	COG0668	transmembrane transport
F1616_RS06450	COG1475	DNA binding
F1616_RS06455	COG0626	cystathionine gamma-synthase activity
F1616_RS06460	COG0626	cystathionine gamma-synthase activity
F1616_RS06465	COG0646	methionine synthase
F1616_RS06465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F1616_RS06470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1616_RS06480	COG0183	Belongs to the thiolase family
F1616_RS06495	COG1476	TRANSCRIPTIONal
F1616_RS06505	COG4555	ABC transporter
F1616_RS06540	COG4932	domain protein
F1616_RS06540	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F1616_RS06540	COG3266	domain, Protein
F1616_RS06565	COG1136	(ABC) transporter
F1616_RS06570	COG0577	efflux transmembrane transporter activity
F1616_RS06590	COG0577	efflux transmembrane transporter activity
F1616_RS06595	COG1136	(ABC) transporter
F1616_RS06635	COG1475	DNA binding
F1616_RS06640	COG0357	Ribosomal RNA small subunit methyltransferase G
F1616_RS06645	COG0445	tRNA wobble uridine modification
F1616_RS06650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1616_RS06655	COG0594	ribonuclease P activity
F1616_RS06665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1616_RS06670	COG0592	DNA-directed DNA polymerase activity
F1616_RS06675	COG2501	S4 domain
F1616_RS06680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F1616_RS06685	COG0187	DNA topoisomerase II activity
F1616_RS06690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1616_RS06695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F1616_RS06700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1616_RS06720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1616_RS06730	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
F1616_RS06735	COG0359	binds to the 23S rRNA
F1616_RS06740	COG0305	Participates in initiation and elongation during chromosome replication
F1616_RS06745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1616_RS06765	COG0745	RESPONSE REGULATOR receiver
F1616_RS06770	COG5002	protein histidine kinase activity
F1616_RS06775	COG4863	YycH protein
F1616_RS06785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F1616_RS06790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F1616_RS06845	COG2217	Heavy metal translocating P-type atpase
F1616_RS06850	COG2132	Multicopper oxidase
F1616_RS06855	COG1388	LysM domain
F1616_RS06860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1616_RS06885	COG0640	Transcriptional regulator
F1616_RS06925	COG2801	Transposase and inactivated derivatives
F1616_RS06930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1616_RS06980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1616_RS06985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1616_RS06995	COG2235	arginine
F1616_RS07045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1616_RS07050	COG4172	Belongs to the ABC transporter superfamily
F1616_RS07055	COG1124	(ABC) transporter
F1616_RS07065	COG0668	transmembrane transport
F1616_RS07070	COG0561	phosphatase activity
F1616_RS07110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F1616_RS07115	COG0579	oxidoreductase
F1616_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS07140	COG1755	Isoprenylcysteine carboxyl methyltransferase
F1616_RS07150	COG4753	response regulator
F1616_RS07150	COG2207	Transcriptional regulator
F1616_RS07155	COG2972	Histidine kinase
F1616_RS07205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F1616_RS07210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1616_RS07215	COG0156	8-amino-7-oxononanoate synthase activity
F1616_RS07220	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
F1616_RS07245	COG0523	cobalamin synthesis protein
F1616_RS07270	COG0431	NADPH-dependent FMN reductase
F1616_RS07270	COG1053	succinate dehydrogenase
F1616_RS07270	COG3976	FMN-binding domain protein
F1616_RS07280	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS07285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F1616_RS07320	COG0601	transmembrane transport
F1616_RS07330	COG0444	Belongs to the ABC transporter superfamily
F1616_RS07335	COG1124	(ABC) transporter
F1616_RS07345	COG1882	Formate acetyltransferase
F1616_RS07350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F1616_RS07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1616_RS07360	COG1114	Component of the transport system for branched-chain amino acids
F1616_RS07365	COG1309	transcriptional regulator
F1616_RS07370	COG3246	L-lysine catabolic process to acetate
F1616_RS07375	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1616_RS07410	COG1288	antiporter activity
F1616_RS07415	COG0549	Belongs to the carbamate kinase family
F1616_RS07420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1616_RS07435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F1616_RS07440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1616_RS07450	COG2376	Dihydroxyacetone kinase
F1616_RS07455	COG1461	Dihydroxyacetone kinase
F1616_RS07460	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
F1616_RS07470	COG2814	Major facilitator Superfamily
F1616_RS07475	COG0583	DNA-binding transcription factor activity
F1616_RS07485	COG2814	Major facilitator Superfamily
F1616_RS07520	COG2814	Major facilitator Superfamily
F1616_RS07535	COG2962	Rard protein
F1616_RS07540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F1616_RS07545	COG0471	metal ion transport
F1616_RS07550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1616_RS07555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1616_RS07560	COG0022	dehydrogenase e1 component
F1616_RS07565	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1616_RS07590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F1616_RS07600	COG3386	PFAM SMP-30 Gluconolaconase
F1616_RS07605	COG2353	YceI-like domain
F1616_RS07615	COG0579	oxidoreductase
F1616_RS07640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F1616_RS07645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1616_RS07650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1616_RS07655	COG0131	Imidazoleglycerol-phosphate dehydratase
F1616_RS07660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1616_RS07665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1616_RS07670	COG0107	imidazoleglycerol-phosphate synthase activity
F1616_RS07675	COG0140	phosphoribosyl-ATP diphosphatase activity
F1616_RS07675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1616_RS07680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
F1616_RS07725	COG2814	Major facilitator Superfamily
F1616_RS07730	COG0737	Belongs to the 5'-nucleotidase family
F1616_RS07745	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F1616_RS07750	COG3639	organic phosphonate transmembrane transporter activity
F1616_RS07770	COG0201	protein transport
F1616_RS07780	COG1073	alpha beta
F1616_RS07790	COG0653	protein targeting
F1616_RS07795	COG0438	transferase activity, transferring glycosyl groups
F1616_RS07820	COG2814	Major facilitator Superfamily
F1616_RS07825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1616_RS07845	COG1764	response to oxidative stress
F1616_RS07855	COG1705	Flagellar rod assembly protein muramidase FlgJ
F1616_RS07855	COG3942	CHAP domain
F1616_RS07865	COG1482	cell wall glycoprotein biosynthetic process
F1616_RS07870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1616_RS07870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1616_RS07870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1616_RS07875	COG3711	transcriptional antiterminator
F1616_RS07875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1616_RS07910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1616_RS07915	COG3227	Zinc metalloprotease (Elastase)
F1616_RS07920	COG1438	arginine binding
F1616_RS07925	COG2235	arginine
F1616_RS07930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1616_RS07940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1616_RS07950	COG2843	Capsule synthesis protein
F1616_RS07960	COG3961	Belongs to the TPP enzyme family
F1616_RS07970	COG1943	Transposase
F1616_RS07990	COG0659	secondary active sulfate transmembrane transporter activity
F1616_RS08010	COG4195	phage-related replication protein
F1616_RS08020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1616_RS08025	COG0702	epimerase
F1616_RS08030	COG1785	Belongs to the alkaline phosphatase family
F1616_RS08045	COG2205	protein histidine kinase activity
F1616_RS08050	COG1136	(ABC) transporter
F1616_RS08065	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1616_RS08090	COG1846	Transcriptional regulator
F1616_RS08095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1616_RS08100	COG0386	Belongs to the glutathione peroxidase family
F1616_RS08110	COG0175	sulfate reduction
F1616_RS08115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F1616_RS08120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1616_RS08135	COG0730	response to heat
F1616_RS08140	COG2046	Belongs to the sulfate adenylyltransferase family
F1616_RS08145	COG0529	Catalyzes the synthesis of activated sulfate
F1616_RS08155	COG1328	CTP reductase activity
F1616_RS08160	COG0602	queuosine metabolic process
F1616_RS08165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F1616_RS08180	COG1510	regulation of RNA biosynthetic process
F1616_RS08190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F1616_RS08195	COG1473	amidohydrolase
F1616_RS08210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1616_RS08215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1616_RS08215	COG0574	Belongs to the PEP-utilizing enzyme family
F1616_RS08220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F1616_RS08225	COG0579	oxidoreductase
F1616_RS08235	COG3588	fructose-bisphosphate aldolase
F1616_RS08245	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1616_RS08280	COG0531	amino acid
F1616_RS08285	COG0583	DNA-binding transcription factor activity
F1616_RS08290	COG0039	L-malate dehydrogenase activity
F1616_RS08295	COG0028	Belongs to the TPP enzyme family
F1616_RS08300	COG3527	Alpha-acetolactate decarboxylase
F1616_RS08310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F1616_RS08315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1616_RS08320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1616_RS08335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1616_RS08350	COG0167	dihydroorotate dehydrogenase activity
F1616_RS08360	COG1113	amino acid transport
F1616_RS08380	COG0741	lytic transglycosylase activity
F1616_RS08400	COG0436	Aminotransferase
F1616_RS08410	COG2608	mercury ion transmembrane transporter activity
F1616_RS08415	COG2217	Heavy metal translocating P-type atpase
F1616_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS08455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1616_RS08460	COG3425	synthase
F1616_RS08480	COG0583	DNA-binding transcription factor activity
F1616_RS08485	COG1380	Effector of murein hydrolase LrgA
F1616_RS08490	COG1346	cytolysis
F1616_RS08495	COG0028	Belongs to the TPP enzyme family
F1616_RS08510	COG1063	alcohol dehydrogenase
F1616_RS08520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F1616_RS08535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1616_RS08545	COG2843	Capsule synthesis protein
F1616_RS08560	COG4975	Glucose uptake
F1616_RS08565	COG1869	D-ribose catabolic process
F1616_RS08575	COG1070	Carbohydrate kinase
F1616_RS08595	COG1760	l-serine dehydratase
F1616_RS08600	COG1760	l-serine dehydratase
F1616_RS08620	COG3764	Sortase (surface protein transpeptidase)
F1616_RS08630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1616_RS08635	COG0778	Nitroreductase
F1616_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS08655	COG2514	catechol 2,3-dioxygenase activity
F1616_RS08670	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS08675	COG3949	Membrane
F1616_RS08690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
F1616_RS08695	COG0586	Pfam SNARE associated Golgi protein
F1616_RS08700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1616_RS08705	COG2022	thiamine diphosphate biosynthetic process
F1616_RS08715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1616_RS08725	COG2271	Major facilitator Superfamily
F1616_RS08740	COG4876	unkown
F1616_RS08745	COG2357	RelA SpoT domain protein
F1616_RS08765	COG0789	Transcriptional regulator
F1616_RS08770	COG2271	Major facilitator Superfamily
F1616_RS08775	COG1802	Transcriptional regulator
F1616_RS08785	COG2610	gluconate transmembrane transporter activity
F1616_RS08790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1616_RS08795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1616_RS08805	COG3316	Transposase and inactivated derivatives
F1616_RS08810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F1616_RS08815	COG3316	Transposase and inactivated derivatives
F1616_RS08850	COG1611	Belongs to the LOG family
F1616_RS08925	COG0217	transcriptional regulatory protein
F1616_RS08935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
F1616_RS08955	COG0583	DNA-binding transcription factor activity
F1616_RS08960	COG2814	Major facilitator Superfamily
F1616_RS08965	COG2839	Protein conserved in bacteria
F1616_RS08990	COG1611	Belongs to the LOG family
F1616_RS08995	COG1671	Belongs to the UPF0178 family
F1616_RS09010	COG1968	undecaprenyl-diphosphatase activity
F1616_RS09015	COG4988	ABC transporter
F1616_RS09020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F1616_RS09025	COG1846	Transcriptional regulator
F1616_RS09045	COG0039	L-malate dehydrogenase activity
F1616_RS09050	COG0471	metal ion transport
F1616_RS09080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F1616_RS09090	COG1349	DNA-binding transcription factor activity
F1616_RS09095	COG1105	Belongs to the carbohydrate kinase PfkB family
F1616_RS09100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1616_RS09100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1616_RS09100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1616_RS09105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F1616_RS09110	COG1253	flavin adenine dinucleotide binding
F1616_RS09115	COG0656	L-ascorbic acid biosynthetic process
F1616_RS09125	COG0463	Glycosyl transferase, family 2
F1616_RS09130	COG5002	protein histidine kinase activity
F1616_RS09135	COG0745	RESPONSE REGULATOR receiver
F1616_RS09165	COG0602	queuosine metabolic process
F1616_RS09170	COG0720	synthase
F1616_RS09175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F1616_RS09185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1616_RS09200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F1616_RS09210	COG1368	sulfuric ester hydrolase activity
F1616_RS09235	COG0488	(ABC) transporter
F1616_RS09240	COG0514	ATP-dependent DNA helicase (RecQ)
F1616_RS09255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1616_RS09260	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
F1616_RS09265	COG1012	belongs to the aldehyde dehydrogenase family
F1616_RS09265	COG1454	alcohol dehydrogenase
F1616_RS09270	COG1597	lipid kinase activity
F1616_RS09280	COG3104	oligopeptide transport
F1616_RS09285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F1616_RS09295	COG1780	Probably involved in ribonucleotide reductase function
F1616_RS09300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1616_RS09305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1616_RS09315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1616_RS09320	COG4605	iron ion homeostasis
F1616_RS09325	COG4604	ABC transporter, ATP-binding protein
F1616_RS09340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F1616_RS09360	COG1929	Belongs to the glycerate kinase type-1 family
F1616_RS09365	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1616_RS09380	COG2199	diguanylate cyclase activity
F1616_RS09385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1616_RS09390	COG1739	Uncharacterized protein family UPF0029
F1616_RS09400	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F1616_RS09405	COG1040	competence protein
F1616_RS09410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F1616_RS09415	COG0653	protein targeting
F1616_RS09425	COG3942	CHAP domain
F1616_RS09425	COG1388	LysM domain
F1616_RS09445	COG0556	nucleotide-excision repair
F1616_RS09450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1616_RS09455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F1616_RS09460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1616_RS09475	COG0492	ferredoxin-NADP+ reductase activity
F1616_RS09480	COG1660	Displays ATPase and GTPase activities
F1616_RS09485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F1616_RS09490	COG1481	regulation of sporulation
F1616_RS09500	COG0740	serine-type endopeptidase activity
F1616_RS09510	COG1090	epimerase
F1616_RS09530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1616_RS09535	COG0126	phosphoglycerate kinase activity
F1616_RS09540	COG0149	triose-phosphate isomerase activity
F1616_RS09545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F1616_RS09550	COG0148	phosphopyruvate hydratase activity
F1616_RS09560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1616_RS09565	COG1647	Serine aminopeptidase, S33
F1616_RS09570	COG0557	exoribonuclease II activity
F1616_RS09575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1616_RS09615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1616_RS09655	COG1278	Cold shock
F1616_RS09670	COG4195	phage-related replication protein
F1616_RS09725	COG1764	response to oxidative stress
F1616_RS09730	COG0710	3-dehydroquinate dehydratase activity
F1616_RS09740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1616_RS09745	COG1393	Belongs to the ArsC family
F1616_RS09750	COG0509	glycine decarboxylation via glycine cleavage system
F1616_RS09760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F1616_RS09770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1616_RS09775	COG2011	ABC-type metal ion transport system permease component
F1616_RS09780	COG1464	Belongs to the NlpA lipoprotein family
F1616_RS09790	COG3237	CsbD-like
F1616_RS09800	COG0396	ATPase activity
F1616_RS09805	COG0719	Fe-S assembly protein
F1616_RS09810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1616_RS09815	COG0822	iron-sulfur transferase activity
F1616_RS09820	COG0719	Fe-S assembly protein
F1616_RS09850	COG1253	flavin adenine dinucleotide binding
F1616_RS09855	COG1801	Protein of unknown function DUF72
F1616_RS09860	COG0730	response to heat
F1616_RS09865	COG0737	Belongs to the 5'-nucleotidase family
F1616_RS09870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1616_RS09875	COG4470	Protein conserved in bacteria
F1616_RS09885	COG2445	Protein of unknown function DUF86
F1616_RS09890	COG0647	UMP catabolic process
F1616_RS09895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1616_RS09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1616_RS09910	COG1696	Membrane protein involved in D-alanine export
F1616_RS09915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1616_RS09920	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F1616_RS09925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F1616_RS09930	COG4837	Protein of unknown function (DUF1462)
F1616_RS09935	COG1252	NADH dehydrogenase
F1616_RS09940	COG4844	belongs to the
F1616_RS09945	COG0316	Belongs to the HesB IscA family
F1616_RS09950	COG1252	NADH dehydrogenase
F1616_RS09955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1616_RS09960	COG2056	Na+-H+ antiporter family
F1616_RS09965	COG2050	protein possibly involved in aromatic compounds catabolism
F1616_RS09975	COG1320	monovalent cation:proton antiporter activity
F1616_RS09980	COG2212	antiporter activity
F1616_RS09985	COG1863	multisubunit Na H antiporter MnhE subunit
F1616_RS09990	COG0651	ATP synthesis coupled electron transport
F1616_RS09995	COG1006	Multisubunit Na H antiporter MnhC subunit
F1616_RS10000	COG2111	Na H antiporter
F1616_RS10005	COG2111	Na H antiporter
F1616_RS10005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1616_RS10015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1616_RS10020	COG1098	S1 RNA binding domain
F1616_RS10025	COG1902	pentaerythritol trinitrate reductase activity
F1616_RS10040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1616_RS10050	COG0584	glycerophosphoryl diester phosphodiesterase
F1616_RS10055	COG0165	Argininosuccinate lyase
F1616_RS10060	COG0137	argininosuccinate synthase activity
F1616_RS10065	COG0166	Belongs to the GPI family
F1616_RS10070	COG0398	Pfam SNARE associated Golgi protein
F1616_RS10085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F1616_RS10090	COG1074	ATP-dependent DNA helicase activity
F1616_RS10095	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1616_RS10115	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1616_RS10120	COG0561	phosphatase activity
F1616_RS10135	COG0542	response to heat
F1616_RS10150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1616_RS10165	COG0601	transmembrane transport
F1616_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1616_RS10175	COG0444	Belongs to the ABC transporter superfamily
F1616_RS10180	COG4608	Belongs to the ABC transporter superfamily
F1616_RS10185	COG4166	transmembrane transport
F1616_RS10190	COG0180	Tryptophanyl-tRNA synthetase
F1616_RS10195	COG1393	Belongs to the ArsC family
F1616_RS10205	COG4862	establishment of competence for transformation
F1616_RS10215	COG1164	Oligoendopeptidase f
F1616_RS10225	COG2346	COG2346, Truncated hemoglobins
F1616_RS10240	COG2357	RelA SpoT domain protein
F1616_RS10245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1616_RS10250	COG0564	pseudouridine synthase activity
F1616_RS10255	COG2239	Acts as a magnesium transporter
F1616_RS10260	COG0475	glutathione-regulated potassium exporter activity
F1616_RS10260	COG0569	domain protein
F1616_RS10285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1616_RS10295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1616_RS10300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1616_RS10310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1616_RS10310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1616_RS10330	COG1943	Transposase
F1616_RS10340	COG0628	permease
F1616_RS10345	COG2382	esterase
F1616_RS10350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F1616_RS10355	COG2814	Major facilitator Superfamily
F1616_RS10360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1616_RS10365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1616_RS10375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F1616_RS10380	COG0861	Integral membrane protein TerC family
F1616_RS10385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1616_RS10390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1616_RS10395	COG0737	Belongs to the 5'-nucleotidase family
F1616_RS10405	COG4873	Protein conserved in bacteria
F1616_RS10465	COG2314	TM2 domain
F1616_RS10475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1616_RS10480	COG1575	Belongs to the MenA family. Type 1 subfamily
F1616_RS10490	COG1169	isochorismate synthase
F1616_RS10495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F1616_RS10505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F1616_RS10510	COG0436	Aminotransferase
F1616_RS10515	COG3594	Acyltransferase
F1616_RS10530	COG2153	protein acetylation
F1616_RS10540	COG1316	TRANSCRIPTIONal
F1616_RS10555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F1616_RS10560	COG1845	cytochrome c oxidase, subunit III
F1616_RS10565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1616_RS10570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1616_RS10580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1616_RS10585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F1616_RS10590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F1616_RS10595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1616_RS10600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1616_RS10605	COG0047	phosphoribosylformylglycinamidine synthase activity
F1616_RS10610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1616_RS10615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F1616_RS10620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1616_RS10625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F1616_RS10630	COG0138	bifunctional purine biosynthesis protein purh
F1616_RS10635	COG0151	Belongs to the GarS family
F1616_RS10640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F1616_RS10645	COG4172	Belongs to the ABC transporter superfamily
F1616_RS10655	COG4716	Myosin-crossreactive antigen
F1616_RS10670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F1616_RS10680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1616_RS10685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1616_RS10695	COG1271	oxidase subunit
F1616_RS10700	COG1294	oxidase, subunit
F1616_RS10705	COG0569	domain protein
F1616_RS10710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1616_RS10720	COG0242	peptide deformylase activity
F1616_RS10730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1616_RS10735	COG0022	dehydrogenase e1 component
F1616_RS10740	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1616_RS10750	COG4476	Belongs to the UPF0223 family
F1616_RS10760	COG3842	ATPase activity
F1616_RS10765	COG1176	ABC-type spermidine putrescine transport system, permease component I
F1616_RS10790	COG1914	H( )-stimulated, divalent metal cation uptake system
F1616_RS10795	COG4493	Belongs to the UPF0637 family
F1616_RS10800	COG0483	inositol monophosphate 1-phosphatase activity
F1616_RS10825	COG4896	Protein conserved in bacteria
F1616_RS10830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1616_RS10835	COG4838	Belongs to the UPF0358 family
F1616_RS10840	COG0772	Belongs to the SEDS family
F1616_RS10845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F1616_RS10850	COG1612	heme a metabolic process
F1616_RS10855	COG0109	protoheme IX farnesyltransferase activity
F1616_RS10865	COG2340	Cysteine-rich secretory protein family
F1616_RS10870	COG3679	Belongs to the UPF0342 family
F1616_RS10875	COG0584	glycerophosphoryl diester phosphodiesterase
F1616_RS10885	COG4471	UPF0298 protein
F1616_RS10895	COG0742	ribosomal rna small subunit methyltransferase
F1616_RS10900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1616_RS10905	COG1323	Belongs to the UPF0348 family
F1616_RS10915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1616_RS10930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1616_RS10935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1616_RS10940	COG0072	phenylalanine-tRNA ligase activity
F1616_RS10940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1616_RS10945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1616_RS10950	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F1616_RS10960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1616_RS10960	COG1796	DNA polymerase
F1616_RS10965	COG1193	negative regulation of DNA recombination
F1616_RS10970	COG3118	belongs to the thioredoxin family
F1616_RS10975	COG0322	excinuclease ABC activity
F1616_RS10980	COG2009	succinate dehydrogenase
F1616_RS10985	COG1053	succinate dehydrogenase
F1616_RS10990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1616_RS10995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1616_RS11000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1616_RS11035	COG1011	Hydrolase
F1616_RS11040	COG0454	-acetyltransferase
F1616_RS11045	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
F1616_RS11050	COG2001	Belongs to the MraZ family
F1616_RS11055	COG0275	rRNA processing
F1616_RS11060	COG4839	cell division protein FtsL
F1616_RS11070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1616_RS11075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1616_RS11080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F1616_RS11085	COG0849	cell division
F1616_RS11090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F1616_RS11100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F1616_RS11105	COG1799	cell septum assembly
F1616_RS11110	COG0762	integral membrane protein
F1616_RS11120	COG3599	regulation of cell shape
F1616_RS11125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1616_RS11135	COG3942	CHAP domain
F1616_RS11135	COG1388	LysM domain
F1616_RS11140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1616_RS11145	COG0564	pseudouridine synthase activity
F1616_RS11150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F1616_RS11155	COG2233	PERMEase
F1616_RS11160	COG0540	Belongs to the ATCase OTCase family
F1616_RS11165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1616_RS11170	COG0505	Belongs to the CarA family
F1616_RS11175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1616_RS11180	COG0284	orotidine-5'-phosphate decarboxylase activity
F1616_RS11185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1616_RS11205	COG0194	GDP metabolic process
F1616_RS11210	COG1758	RNA polymerase activity
F1616_RS11215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1616_RS11220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F1616_RS11230	COG0242	peptide deformylase activity
F1616_RS11235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1616_RS11240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F1616_RS11240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1616_RS11245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1616_RS11250	COG0631	protein serine/threonine phosphatase activity
F1616_RS11260	COG1162	GTPase activity
F1616_RS11265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1616_RS11275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1616_RS11280	COG1302	Protein conserved in bacteria
F1616_RS11285	COG1461	Dihydroxyacetone kinase
F1616_RS11290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1616_RS11295	COG1349	DNA-binding transcription factor activity
F1616_RS11300	COG0416	fatty acid biosynthetic process
F1616_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
F1616_RS11315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1616_RS11320	COG0571	ribonuclease III activity
F1616_RS11325	COG1196	nuclear chromosome segregation
F1616_RS11330	COG0552	protein localization to endoplasmic reticulum
F1616_RS11335	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F1616_RS11340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1616_RS11345	COG0228	four-way junction DNA binding
F1616_RS11350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1616_RS11355	COG0336	Belongs to the RNA methyltransferase TrmD family
F1616_RS11360	COG0335	large ribosomal subunit rRNA binding
F1616_RS11370	COG4485	Bacterial membrane protein, YfhO
F1616_RS11385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1616_RS11390	COG0045	succinate-CoA ligase (ADP-forming) activity
F1616_RS11395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F1616_RS11400	COG0758	DNA mediated transformation
F1616_RS11405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1616_RS11410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F1616_RS11415	COG4974	Belongs to the 'phage' integrase family
F1616_RS11420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F1616_RS11425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F1616_RS11430	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F1616_RS11435	COG0052	Belongs to the universal ribosomal protein uS2 family
F1616_RS11440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1616_RS11445	COG0528	UMP kinase activity
F1616_RS11450	COG0233	cytoplasmic translational termination
F1616_RS11455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1616_RS11460	COG4589	Belongs to the CDS family
F1616_RS11470	COG0442	prolyl-tRNA aminoacylation
F1616_RS11475	COG2176	DNA-directed DNA polymerase activity
F1616_RS11480	COG0779	Required for maturation of 30S ribosomal subunits
F1616_RS11485	COG0195	Participates in both transcription termination and antitermination
F1616_RS11490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F1616_RS11495	COG1358	cellular component organization or biogenesis
F1616_RS11500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1616_RS11505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1616_RS11510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1616_RS11515	COG0196	riboflavin kinase activity
F1616_RS11520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1616_RS11525	COG1185	polyribonucleotide nucleotidyltransferase activity
F1616_RS11530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1616_RS11535	COG1674	ftsk spoiiie
F1616_RS11540	COG2188	Transcriptional regulator
F1616_RS11545	COG0612	Peptidase, M16
F1616_RS11550	COG0612	Peptidase, M16
F1616_RS11555	COG0300	oxidoreductase activity
F1616_RS11570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1616_RS11580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1616_RS11585	COG1418	mRNA catabolic process
F1616_RS11595	COG1692	metallophosphoesterase
F1616_RS11600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1616_RS11600	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1616_RS11605	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1616_RS11610	COG4195	phage-related replication protein
F1616_RS11620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1616_RS11625	COG4550	Control of competence regulator ComK, YlbF/YmcA
F1616_RS11635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1616_RS11640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F1616_RS11645	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
F1616_RS11650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F1616_RS11655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1616_RS11660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1616_RS11670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1616_RS11675	COG1923	regulation of RNA biosynthetic process
F1616_RS11680	COG0386	Belongs to the glutathione peroxidase family
F1616_RS11690	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F1616_RS11695	COG0789	Transcriptional regulator
F1616_RS11700	COG0174	glutamine synthetase
F1616_RS11745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1616_RS11750	COG1131	(ABC) transporter
F1616_RS11760	COG4585	Histidine kinase
F1616_RS11765	COG2197	response regulator
F1616_RS11775	COG1525	nuclease
F1616_RS11790	COG0527	aspartate kinase activity
F1616_RS11795	COG0460	homoserine dehydrogenase
F1616_RS11800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1616_RS11805	COG0083	homoserine kinase activity
F1616_RS11820	COG0833	amino acid
F1616_RS11825	COG0753	catalase activity
F1616_RS11835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1616_RS11840	COG0516	GMP reductase activity
F1616_RS11845	COG2340	Cysteine-rich secretory protein family
F1616_RS11855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1616_RS11865	COG4224	UPF0291 protein
F1616_RS11870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F1616_RS11880	COG4846	Membrane protein involved in cytochrome C biogenesis
F1616_RS11885	COG0420	3'-5' exonuclease activity
F1616_RS11890	COG0419	ATPase involved in DNA repair
F1616_RS11895	COG1970	mechanosensitive ion channel activity
F1616_RS11900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F1616_RS11905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F1616_RS11910	COG0824	Thioesterase
F1616_RS11915	COG4841	protein insertion into membrane
F1616_RS11920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F1616_RS11925	COG0187	DNA topoisomerase II activity
F1616_RS11930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1616_RS11935	COG1115	amino acid carrier protein
F1616_RS11945	COG0628	permease
F1616_RS11950	COG0392	lysyltransferase activity
F1616_RS11950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1616_RS11955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1616_RS11960	COG1316	TRANSCRIPTIONal
F1616_RS11970	COG1942	4-Oxalocrotonate Tautomerase
F1616_RS11975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1616_RS11980	COG0287	Prephenate dehydrogenase
F1616_RS11985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1616_RS11990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1616_RS11990	COG0512	Glutamine amidotransferase of anthranilate synthase
F1616_RS11995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1616_RS12000	COG0134	indole-3-glycerol-phosphate synthase activity
F1616_RS12005	COG0135	phosphoribosylanthranilate isomerase activity
F1616_RS12010	COG0133	tryptophan synthase activity
F1616_RS12015	COG0159	tryptophan synthase activity
F1616_RS12030	COG2348	transferase activity, transferring amino-acyl groups
F1616_RS12035	COG2348	transferase activity, transferring amino-acyl groups