locus-tag	class	description
ICN77_RS00010	COG3237	CsbD-like
ICN77_RS00030	COG1757	Na H antiporter
ICN77_RS00050	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS00065	COG3237	CsbD-like
ICN77_RS00195	COG3942	CHAP domain
ICN77_RS00195	COG1388	LysM domain
ICN77_RS00305	COG1686	Belongs to the peptidase S11 family
ICN77_RS00335	COG3237	CsbD-like
ICN77_RS00395	COG3764	Sortase (surface protein transpeptidase)
ICN77_RS00420	COG2814	Major facilitator Superfamily
ICN77_RS00435	COG1131	(ABC) transporter
ICN77_RS00440	COG4195	phage-related replication protein
ICN77_RS00455	COG1131	(ABC) transporter
ICN77_RS00470	COG2311	Membrane
ICN77_RS00500	COG3237	CsbD-like
ICN77_RS00540	COG2161	toxin-antitoxin pair type II binding
ICN77_RS00565	COG1686	Belongs to the peptidase S11 family
ICN77_RS00600	COG1192	Involved in chromosome partitioning
ICN77_RS00610	COG1611	Belongs to the LOG family
ICN77_RS00660	COG1136	(ABC) transporter
ICN77_RS00660	COG0577	efflux transmembrane transporter activity
ICN77_RS00730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ICN77_RS00735	COG0592	DNA-directed DNA polymerase activity
ICN77_RS00740	COG2501	S4 domain
ICN77_RS00745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ICN77_RS00750	COG0187	DNA topoisomerase II activity
ICN77_RS00755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICN77_RS00760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ICN77_RS00765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ICN77_RS00785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ICN77_RS00795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ICN77_RS00800	COG0359	binds to the 23S rRNA
ICN77_RS00805	COG0305	Participates in initiation and elongation during chromosome replication
ICN77_RS00810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ICN77_RS00825	COG0745	RESPONSE REGULATOR receiver
ICN77_RS00830	COG5002	protein histidine kinase activity
ICN77_RS00835	COG4863	YycH protein
ICN77_RS00845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ICN77_RS00850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ICN77_RS00895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ICN77_RS00955	COG0549	Belongs to the carbamate kinase family
ICN77_RS00960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ICN77_RS00965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ICN77_RS00975	COG2235	arginine
ICN77_RS00980	COG1438	arginine binding
ICN77_RS01015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ICN77_RS01020	COG1131	(ABC) transporter
ICN77_RS01035	COG0745	RESPONSE REGULATOR receiver
ICN77_RS01040	COG5002	protein histidine kinase activity
ICN77_RS01055	COG2217	Heavy metal translocating P-type atpase
ICN77_RS01060	COG2132	Multicopper oxidase
ICN77_RS01065	COG1388	LysM domain
ICN77_RS01070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ICN77_RS01075	COG2210	Belongs to the sulfur carrier protein TusA family
ICN77_RS01080	COG1937	Protein conserved in bacteria
ICN77_RS01085	COG0730	response to heat
ICN77_RS01095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ICN77_RS01115	COG0640	Transcriptional regulator
ICN77_RS01120	COG0701	Predicted permease
ICN77_RS01130	COG0668	transmembrane transport
ICN77_RS01135	COG0561	phosphatase activity
ICN77_RS01165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ICN77_RS01170	COG0579	oxidoreductase
ICN77_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS01185	COG1755	Isoprenylcysteine carboxyl methyltransferase
ICN77_RS01195	COG2207	Transcriptional regulator
ICN77_RS01195	COG4753	response regulator
ICN77_RS01200	COG2972	Histidine kinase
ICN77_RS01240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ICN77_RS01245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ICN77_RS01250	COG0156	8-amino-7-oxononanoate synthase activity
ICN77_RS01255	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ICN77_RS01280	COG0523	cobalamin synthesis protein
ICN77_RS01295	COG0803	Belongs to the bacterial solute-binding protein 9 family
ICN77_RS01305	COG1053	succinate dehydrogenase
ICN77_RS01305	COG3976	FMN-binding domain protein
ICN77_RS01305	COG0431	NADPH-dependent FMN reductase
ICN77_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS01350	COG0601	transmembrane transport
ICN77_RS01360	COG0444	Belongs to the ABC transporter superfamily
ICN77_RS01365	COG1124	(ABC) transporter
ICN77_RS01375	COG1882	Formate acetyltransferase
ICN77_RS01380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ICN77_RS01385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICN77_RS01390	COG1114	Component of the transport system for branched-chain amino acids
ICN77_RS01395	COG1309	transcriptional regulator
ICN77_RS01400	COG3246	L-lysine catabolic process to acetate
ICN77_RS01405	COG1250	3-hydroxyacyl-CoA dehydrogenase
ICN77_RS01440	COG1288	antiporter activity
ICN77_RS01445	COG0549	Belongs to the carbamate kinase family
ICN77_RS01450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ICN77_RS01460	COG0346	lactoylglutathione lyase activity
ICN77_RS01470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ICN77_RS01480	COG2376	Dihydroxyacetone kinase
ICN77_RS01485	COG1461	Dihydroxyacetone kinase
ICN77_RS01490	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ICN77_RS01505	COG2814	Major facilitator Superfamily
ICN77_RS01535	COG2814	Major facilitator Superfamily
ICN77_RS01550	COG2962	Rard protein
ICN77_RS01555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ICN77_RS01565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ICN77_RS01570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ICN77_RS01575	COG0022	dehydrogenase e1 component
ICN77_RS01580	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICN77_RS01600	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ICN77_RS01605	COG1054	Belongs to the UPF0176 family
ICN77_RS01610	COG3386	PFAM SMP-30 Gluconolaconase
ICN77_RS01615	COG2353	YceI-like domain
ICN77_RS01620	COG0579	oxidoreductase
ICN77_RS01645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ICN77_RS01650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ICN77_RS01655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ICN77_RS01660	COG0131	Imidazoleglycerol-phosphate dehydratase
ICN77_RS01665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ICN77_RS01670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ICN77_RS01675	COG0107	imidazoleglycerol-phosphate synthase activity
ICN77_RS01680	COG0140	phosphoribosyl-ATP diphosphatase activity
ICN77_RS01680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ICN77_RS01685	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ICN77_RS01690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ICN77_RS01705	COG2814	Major facilitator Superfamily
ICN77_RS01710	COG0737	Belongs to the 5'-nucleotidase family
ICN77_RS01725	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ICN77_RS01730	COG3639	organic phosphonate transmembrane transporter activity
ICN77_RS01750	COG0201	protein transport
ICN77_RS01760	COG1073	alpha beta
ICN77_RS01775	COG0438	transferase activity, transferring glycosyl groups
ICN77_RS01800	COG2814	Major facilitator Superfamily
ICN77_RS01805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ICN77_RS01825	COG1764	response to oxidative stress
ICN77_RS01835	COG3942	CHAP domain
ICN77_RS01835	COG1705	Flagellar rod assembly protein muramidase FlgJ
ICN77_RS01845	COG1482	cell wall glycoprotein biosynthetic process
ICN77_RS01850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ICN77_RS01850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ICN77_RS01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICN77_RS01855	COG3711	transcriptional antiterminator
ICN77_RS01855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICN77_RS01885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICN77_RS01890	COG3227	Zinc metalloprotease (Elastase)
ICN77_RS01895	COG1438	arginine binding
ICN77_RS01900	COG2235	arginine
ICN77_RS01905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ICN77_RS01915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ICN77_RS01925	COG2843	Capsule synthesis protein
ICN77_RS01930	COG3961	Belongs to the TPP enzyme family
ICN77_RS01960	COG4195	phage-related replication protein
ICN77_RS01970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ICN77_RS01980	COG1785	Belongs to the alkaline phosphatase family
ICN77_RS01995	COG2205	protein histidine kinase activity
ICN77_RS02000	COG1136	(ABC) transporter
ICN77_RS02015	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ICN77_RS02040	COG1846	Transcriptional regulator
ICN77_RS02050	COG0386	Belongs to the glutathione peroxidase family
ICN77_RS02055	COG0175	sulfate reduction
ICN77_RS02060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ICN77_RS02065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ICN77_RS02080	COG0730	response to heat
ICN77_RS02085	COG2046	Belongs to the sulfate adenylyltransferase family
ICN77_RS02090	COG0529	Catalyzes the synthesis of activated sulfate
ICN77_RS02100	COG1328	CTP reductase activity
ICN77_RS02105	COG0602	queuosine metabolic process
ICN77_RS02110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ICN77_RS02120	COG1510	regulation of RNA biosynthetic process
ICN77_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS02130	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ICN77_RS02135	COG1473	amidohydrolase
ICN77_RS02150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ICN77_RS02155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICN77_RS02155	COG0574	Belongs to the PEP-utilizing enzyme family
ICN77_RS02160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ICN77_RS02165	COG0579	oxidoreductase
ICN77_RS02175	COG3588	fructose-bisphosphate aldolase
ICN77_RS02180	COG0446	pyridine nucleotide-disulphide oxidoreductase
ICN77_RS02215	COG0531	amino acid
ICN77_RS02220	COG0583	DNA-binding transcription factor activity
ICN77_RS02225	COG0039	L-malate dehydrogenase activity
ICN77_RS02230	COG0028	Belongs to the TPP enzyme family
ICN77_RS02235	COG3527	Alpha-acetolactate decarboxylase
ICN77_RS02245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ICN77_RS02250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ICN77_RS02255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ICN77_RS02270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ICN77_RS02285	COG0167	dihydroorotate dehydrogenase activity
ICN77_RS02290	COG3001	Fructosamine kinase
ICN77_RS02295	COG1113	amino acid transport
ICN77_RS02310	COG0741	lytic transglycosylase activity
ICN77_RS02320	COG3942	CHAP domain
ICN77_RS02325	COG0436	Aminotransferase
ICN77_RS02335	COG2608	mercury ion transmembrane transporter activity
ICN77_RS02340	COG2217	Heavy metal translocating P-type atpase
ICN77_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS02380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ICN77_RS02385	COG3425	synthase
ICN77_RS02405	COG0583	DNA-binding transcription factor activity
ICN77_RS02410	COG1380	Effector of murein hydrolase LrgA
ICN77_RS02415	COG1346	cytolysis
ICN77_RS02420	COG0028	Belongs to the TPP enzyme family
ICN77_RS02425	COG1263	PTS System
ICN77_RS02425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ICN77_RS02425	COG2190	(PTS) system
ICN77_RS02435	COG1063	alcohol dehydrogenase
ICN77_RS02445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ICN77_RS02460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ICN77_RS02470	COG2843	Capsule synthesis protein
ICN77_RS02485	COG4975	Glucose uptake
ICN77_RS02490	COG1869	D-ribose catabolic process
ICN77_RS02505	COG1070	Carbohydrate kinase
ICN77_RS02520	COG1760	l-serine dehydratase
ICN77_RS02525	COG1760	l-serine dehydratase
ICN77_RS02550	COG3764	Sortase (surface protein transpeptidase)
ICN77_RS02560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICN77_RS02565	COG0778	Nitroreductase
ICN77_RS02570	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS02580	COG2514	catechol 2,3-dioxygenase activity
ICN77_RS02595	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS02600	COG3949	Membrane
ICN77_RS02610	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ICN77_RS02615	COG0586	Pfam SNARE associated Golgi protein
ICN77_RS02620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ICN77_RS02625	COG2022	thiamine diphosphate biosynthetic process
ICN77_RS02635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ICN77_RS02645	COG2271	Major facilitator Superfamily
ICN77_RS02660	COG4876	unkown
ICN77_RS02665	COG2357	RelA SpoT domain protein
ICN77_RS02680	COG0789	Transcriptional regulator
ICN77_RS02685	COG2271	Major facilitator Superfamily
ICN77_RS02690	COG1802	Transcriptional regulator
ICN77_RS02700	COG2610	gluconate transmembrane transporter activity
ICN77_RS02705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ICN77_RS02710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ICN77_RS02715	COG0438	transferase activity, transferring glycosyl groups
ICN77_RS02740	COG4221	oxidoreductase activity
ICN77_RS02745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICN77_RS02750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ICN77_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS02770	COG1363	Peptidase, m42
ICN77_RS02780	COG0069	glutamate synthase activity
ICN77_RS02795	COG4619	ABC transporter
ICN77_RS02800	COG0390	transport system, permease component
ICN77_RS02805	COG2814	Major facilitator Superfamily
ICN77_RS02810	COG2272	Belongs to the type-B carboxylesterase lipase family
ICN77_RS02815	COG0531	amino acid
ICN77_RS02825	COG1063	alcohol dehydrogenase
ICN77_RS02845	COG1174	glycine betaine transport
ICN77_RS02850	COG1346	cytolysis
ICN77_RS02855	COG1380	Effector of murein hydrolase LrgA
ICN77_RS02860	COG3279	Response regulator of the LytR AlgR family
ICN77_RS02865	COG3275	phosphorelay sensor kinase activity
ICN77_RS02875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ICN77_RS02880	COG0706	membrane insertase activity
ICN77_RS02890	COG0531	amino acid
ICN77_RS02895	COG1113	amino acid transport
ICN77_RS02920	COG1929	Belongs to the glycerate kinase type-1 family
ICN77_RS02935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ICN77_RS02940	COG0588	phosphoglycerate mutase activity
ICN77_RS02950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ICN77_RS02955	COG0765	amino acid transport
ICN77_RS02960	COG1126	abc transporter atp-binding protein
ICN77_RS02965	COG2348	transferase activity, transferring amino-acyl groups
ICN77_RS02985	COG2116	formate transmembrane transporter activity
ICN77_RS03005	COG0747	negative chemotaxis
ICN77_RS03015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ICN77_RS03020	COG2146	nitrite reductase [NAD(P)H] activity
ICN77_RS03030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ICN77_RS03035	COG1140	nitrate reductase beta subunit
ICN77_RS03045	COG2181	nitrate reductase activity
ICN77_RS03055	COG4585	Histidine kinase
ICN77_RS03060	COG2197	response regulator
ICN77_RS03065	COG2223	nitrite transmembrane transporter activity
ICN77_RS03070	COG1846	Transcriptional regulator
ICN77_RS03075	COG0778	Nitroreductase
ICN77_RS03115	COG3871	stress protein (general stress protein 26)
ICN77_RS03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ICN77_RS03130	COG1263	PTS System
ICN77_RS03165	COG0604	alcohol dehydrogenase
ICN77_RS03170	COG0456	acetyltransferase
ICN77_RS03175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ICN77_RS03175	COG0463	Glycosyl transferase, family 2
ICN77_RS03185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ICN77_RS03185	COG0463	Glycosyl transferase, family 2
ICN77_RS03190	COG1620	l-lactate permease
ICN77_RS03195	COG0438	transferase activity, transferring glycosyl groups
ICN77_RS03200	COG0579	oxidoreductase
ICN77_RS03205	COG3850	Histidine kinase
ICN77_RS03205	COG5002	protein histidine kinase activity
ICN77_RS03210	COG0745	RESPONSE REGULATOR receiver
ICN77_RS03215	COG0577	efflux transmembrane transporter activity
ICN77_RS03220	COG1136	(ABC) transporter
ICN77_RS03235	COG4640	response to antibiotic
ICN77_RS03240	COG2814	Major facilitator Superfamily
ICN77_RS03250	COG1566	PFAM secretion protein HlyD family protein
ICN77_RS03255	COG2814	Major facilitator Superfamily
ICN77_RS03265	COG0657	acetylesterase activity
ICN77_RS03280	COG0598	Magnesium transport protein CorA
ICN77_RS03285	COG1304	FMN binding
ICN77_RS03290	COG0786	glutamate:sodium symporter activity
ICN77_RS03310	COG2094	Belongs to the DNA glycosylase MPG family
ICN77_RS03320	COG1069	ribulokinase activity
ICN77_RS03325	COG2017	converts alpha-aldose to the beta-anomer
ICN77_RS03330	COG2258	MOSC domain
ICN77_RS03335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ICN77_RS03345	COG1266	CAAX protease self-immunity
ICN77_RS03350	COG0010	Belongs to the arginase family
ICN77_RS03355	COG1473	amidohydrolase
ICN77_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS03365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ICN77_RS03395	COG1737	Transcriptional regulator
ICN77_RS03400	COG1263	PTS System
ICN77_RS03400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ICN77_RS03410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ICN77_RS03430	COG1113	amino acid transport
ICN77_RS03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ICN77_RS03440	COG1263	PTS System
ICN77_RS03445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ICN77_RS03460	COG1266	CAAX protease self-immunity
ICN77_RS03465	COG2378	regulation of single-species biofilm formation
ICN77_RS03470	COG0483	inositol monophosphate 1-phosphatase activity
ICN77_RS03475	COG1316	TRANSCRIPTIONal
ICN77_RS03495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICN77_RS03500	COG2076	Multidrug Resistance protein
ICN77_RS03505	COG2076	Multidrug Resistance protein
ICN77_RS03510	COG3942	CHAP domain
ICN77_RS03525	COG1757	Na H antiporter
ICN77_RS03530	COG3942	CHAP domain
ICN77_RS03555	COG0829	nickel cation binding
ICN77_RS03560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ICN77_RS03565	COG0830	nickel cation binding
ICN77_RS03570	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ICN77_RS03575	COG0804	urea catabolic process
ICN77_RS03580	COG0832	Belongs to the urease beta subunit family
ICN77_RS03585	COG0831	urea catabolic process
ICN77_RS03595	COG1960	acyl-CoA dehydrogenase activity
ICN77_RS03600	COG1957	nucleoside hydrolase
ICN77_RS03605	COG1268	BioY protein
ICN77_RS03620	COG0725	ABC transporter, periplasmic molybdate-binding protein
ICN77_RS03625	COG4149	molybdate abc transporter
ICN77_RS03630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ICN77_RS03635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ICN77_RS03640	COG0521	Mo-molybdopterin cofactor biosynthetic process
ICN77_RS03645	COG0315	cyclic pyranopterin monophosphate synthase activity
ICN77_RS03650	COG0303	'Molybdopterin
ICN77_RS03660	COG0314	molybdopterin synthase activity
ICN77_RS03670	COG0746	molybdenum cofactor guanylyltransferase activity
ICN77_RS03675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ICN77_RS03700	COG2814	Major facilitator Superfamily
ICN77_RS03715	COG2348	transferase activity, transferring amino-acyl groups
ICN77_RS03720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ICN77_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS03745	COG4975	Glucose uptake
ICN77_RS03750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ICN77_RS03750	COG0551	DNA topoisomerase type I activity
ICN77_RS03755	COG2252	PERMEase
ICN77_RS03770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ICN77_RS03775	COG0088	Forms part of the polypeptide exit tunnel
ICN77_RS03780	COG0089	rRNA binding
ICN77_RS03785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ICN77_RS03790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ICN77_RS03795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ICN77_RS03800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ICN77_RS03805	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ICN77_RS03815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ICN77_RS03820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ICN77_RS03825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ICN77_RS03830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ICN77_RS03835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ICN77_RS03840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ICN77_RS03845	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ICN77_RS03850	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ICN77_RS03855	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ICN77_RS03860	COG1841	ribosomal large subunit assembly
ICN77_RS03865	COG0200	Binds to the 23S rRNA
ICN77_RS03870	COG0201	protein transport
ICN77_RS03875	COG0563	adenylate kinase activity
ICN77_RS03880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ICN77_RS03885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ICN77_RS03890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ICN77_RS03895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ICN77_RS03900	COG0202	RNA polymerase activity
ICN77_RS03905	COG0203	ribosomal protein L17
ICN77_RS03910	COG1122	ATPase activity
ICN77_RS03915	COG1122	ATPase activity
ICN77_RS03925	COG0101	tRNA pseudouridine synthase activity
ICN77_RS03930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ICN77_RS03935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ICN77_RS03940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ICN77_RS03945	COG1349	DNA-binding transcription factor activity
ICN77_RS03950	COG0698	ribose 5-phosphate isomerase
ICN77_RS03955	COG0698	ribose 5-phosphate isomerase
ICN77_RS03960	COG1105	Belongs to the carbohydrate kinase PfkB family
ICN77_RS03965	COG3684	Belongs to the aldolase LacD family
ICN77_RS03970	COG1447	Phosphotransferase system cellobiose-specific component IIA
ICN77_RS03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ICN77_RS03995	COG2130	NADP-dependent
ICN77_RS04000	COG0604	alcohol dehydrogenase
ICN77_RS04015	COG1302	Protein conserved in bacteria
ICN77_RS04020	COG4264	IucA IucC family
ICN77_RS04025	COG2814	Major facilitator Superfamily
ICN77_RS04030	COG4264	IucA IucC family
ICN77_RS04035	COG3457	Alanine racemase
ICN77_RS04040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ICN77_RS04045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICN77_RS04050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICN77_RS04055	COG3314	Sporulation integral membrane protein YlbJ
ICN77_RS04060	COG2329	Antibiotic biosynthesis monooxygenase
ICN77_RS04070	COG1988	membrane-bound metal-dependent
ICN77_RS04075	COG4284	Utp--glucose-1-phosphate uridylyltransferase
ICN77_RS04095	COG2814	Major facilitator Superfamily
ICN77_RS04100	COG0489	protein tyrosine kinase activity
ICN77_RS04150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ICN77_RS04160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ICN77_RS04175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ICN77_RS04180	COG0561	phosphatase activity
ICN77_RS04200	COG0640	Transcriptional regulator
ICN77_RS04205	COG0702	epimerase
ICN77_RS04210	COG1482	cell wall glycoprotein biosynthetic process
ICN77_RS04230	COG0783	Belongs to the Dps family
ICN77_RS04235	COG0813	purine-nucleoside phosphorylase activity
ICN77_RS04240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ICN77_RS04245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ICN77_RS04250	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ICN77_RS04260	COG1854	S-ribosylhomocysteine lyase activity
ICN77_RS04280	COG5146	pantothenate kinase activity
ICN77_RS04295	COG0504	CTP synthase activity
ICN77_RS04305	COG0191	fructose-bisphosphate aldolase activity
ICN77_RS04310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ICN77_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS04320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ICN77_RS04325	COG0254	rRNA binding
ICN77_RS04330	COG1435	thymidine kinase activity
ICN77_RS04335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ICN77_RS04340	COG2890	protein-(glutamine-N5) methyltransferase activity
ICN77_RS04345	COG0009	L-threonylcarbamoyladenylate synthase
ICN77_RS04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ICN77_RS04355	COG4475	Protein of unknown function (DUF436)
ICN77_RS04360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ICN77_RS04365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ICN77_RS04370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ICN77_RS04380	COG0356	it plays a direct role in the translocation of protons across the membrane
ICN77_RS04390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ICN77_RS04395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ICN77_RS04400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ICN77_RS04405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ICN77_RS04410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ICN77_RS04415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ICN77_RS04425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ICN77_RS04430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ICN77_RS04440	COG0629	single-stranded DNA binding
ICN77_RS04445	COG1388	LysM domain
ICN77_RS04450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ICN77_RS04460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ICN77_RS04465	COG0352	thiamine-phosphate diphosphorylase activity
ICN77_RS04470	COG0706	membrane insertase activity
ICN77_RS04475	COG1418	mRNA catabolic process
ICN77_RS04480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICN77_RS04485	COG1937	Protein conserved in bacteria
ICN77_RS04500	COG0772	Belongs to the SEDS family
ICN77_RS04505	COG1181	Belongs to the D-alanine--D-alanine ligase family
ICN77_RS04510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ICN77_RS04515	COG0513	Belongs to the DEAD box helicase family
ICN77_RS04525	COG3428	Bacterial PH domain
ICN77_RS04530	COG3402	PFAM membrane-flanked domain
ICN77_RS04535	COG0736	holo-[acyl-carrier-protein] synthase activity
ICN77_RS04540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ICN77_RS04550	COG2337	Toxic component of a toxin-antitoxin (TA) module
ICN77_RS04555	COG2208	phosphoserine phosphatase activity
ICN77_RS04570	COG1191	sigma factor activity
ICN77_RS04575	COG2183	response to ionizing radiation
ICN77_RS04580	COG3091	SprT-like family
ICN77_RS04610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ICN77_RS04615	COG0066	3-isopropylmalate dehydratase activity
ICN77_RS04620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ICN77_RS04625	COG0473	3-isopropylmalate dehydrogenase activity
ICN77_RS04630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ICN77_RS04635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ICN77_RS04645	COG0028	Belongs to the TPP enzyme family
ICN77_RS04650	COG0129	dihydroxy-acid dehydratase activity
ICN77_RS04655	COG0802	atpase or kinase
ICN77_RS04660	COG1214	PFAM Peptidase M22, glycoprotease
ICN77_RS04665	COG0456	acetyltransferase
ICN77_RS04670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ICN77_RS04675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ICN77_RS04680	COG0488	(ABC) transporter
ICN77_RS04685	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ICN77_RS04695	COG2391	methyltransferase activity
ICN77_RS04700	COG0425	Belongs to the sulfur carrier protein TusA family
ICN77_RS04705	COG0004	ammonium transporteR
ICN77_RS04710	COG1609	Transcriptional regulator
ICN77_RS04715	COG1621	beta-fructofuranosidase activity
ICN77_RS04720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICN77_RS04725	COG3279	Response regulator of the LytR AlgR family
ICN77_RS04730	COG3290	protein histidine kinase activity
ICN77_RS04765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ICN77_RS04770	COG0459	protein refolding
ICN77_RS04790	COG1725	Transcriptional regulator
ICN77_RS04795	COG1131	(ABC) transporter
ICN77_RS04805	COG1131	(ABC) transporter
ICN77_RS04850	COG2706	6-phosphogluconolactonase activity
ICN77_RS04855	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS04860	COG1227	inorganic diphosphatase activity
ICN77_RS04865	COG1335	isochorismatase
ICN77_RS04875	COG0077	Prephenate dehydratase
ICN77_RS04885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ICN77_RS04890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ICN77_RS04895	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ICN77_RS04905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ICN77_RS04910	COG4496	protein, YerC YecD
ICN77_RS04915	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ICN77_RS04920	COG0210	DNA helicase
ICN77_RS04925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ICN77_RS04930	COG4851	CamS sex pheromone cAM373 precursor
ICN77_RS04935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ICN77_RS04940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICN77_RS04945	COG0154	amidase activity
ICN77_RS04950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICN77_RS04955	COG1597	lipid kinase activity
ICN77_RS04960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ICN77_RS04970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ICN77_RS04980	COG1528	Iron-storage protein
ICN77_RS05000	COG4129	membrane
ICN77_RS05005	COG0024	Methionine aminopeptidase
ICN77_RS05020	COG4585	Histidine kinase
ICN77_RS05025	COG2197	response regulator
ICN77_RS05030	COG1295	ribonuclease BN
ICN77_RS05040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ICN77_RS05045	COG4840	Belongs to the UPF0435 family
ICN77_RS05050	COG2309	aminopeptidase activity
ICN77_RS05055	COG1607	acyl-coa hydrolase
ICN77_RS05060	COG0535	radical SAM domain protein
ICN77_RS05070	COG0693	protein deglycase activity
ICN77_RS05075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ICN77_RS05080	COG2137	regulation of response to DNA damage stimulus
ICN77_RS05090	COG1388	LysM domain
ICN77_RS05090	COG1134	teichoic acid transport
ICN77_RS05100	COG1988	membrane-bound metal-dependent
ICN77_RS05110	COG3557	Belongs to the UPF0374 family
ICN77_RS05120	COG4129	membrane
ICN77_RS05125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ICN77_RS05130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ICN77_RS05135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICN77_RS05140	COG0735	belongs to the Fur family
ICN77_RS05310	COG0765	amino acid transport
ICN77_RS05315	COG1126	abc transporter atp-binding protein
ICN77_RS05325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ICN77_RS05350	COG0114	fumarate hydratase activity
ICN77_RS05355	COG0564	pseudouridine synthase activity
ICN77_RS05360	COG2203	Gaf domain
ICN77_RS05360	COG4585	Histidine kinase
ICN77_RS05365	COG2197	response regulator
ICN77_RS05375	COG4399	Belongs to the UPF0754 family
ICN77_RS05380	COG3679	Belongs to the UPF0342 family
ICN77_RS05385	COG0420	3'-5' exonuclease activity
ICN77_RS05395	COG3481	metal-dependent phosphohydrolase, HD sub domain
ICN77_RS05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ICN77_RS05420	COG0537	adenosine 5'-monophosphoramidase activity
ICN77_RS05425	COG1131	(ABC) transporter
ICN77_RS05430	COG4473	ABC transporter
ICN77_RS05440	COG2329	Antibiotic biosynthesis monooxygenase
ICN77_RS05445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ICN77_RS05450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ICN77_RS05455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ICN77_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
ICN77_RS05545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ICN77_RS05550	COG0494	nUDIX hydrolase
ICN77_RS05555	COG1506	peptidase
ICN77_RS05560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ICN77_RS05565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ICN77_RS05575	COG0656	L-ascorbic acid biosynthetic process
ICN77_RS05590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ICN77_RS05595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ICN77_RS05605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ICN77_RS05630	COG4193	domain, Protein
ICN77_RS05630	COG3266	domain, Protein
ICN77_RS05630	COG5632	N-Acetylmuramoyl-L-alanine amidase
ICN77_RS05640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ICN77_RS05640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ICN77_RS05650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ICN77_RS05650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ICN77_RS05655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ICN77_RS05660	COG0506	proline dehydrogenase activity
ICN77_RS05665	COG2267	carboxylic ester hydrolase activity
ICN77_RS05675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ICN77_RS05680	COG1242	4 iron, 4 sulfur cluster binding
ICN77_RS05685	COG2814	Major facilitator Superfamily
ICN77_RS05690	COG0495	leucyl-tRNA aminoacylation
ICN77_RS05705	COG2081	HI0933 family
ICN77_RS05710	COG2244	polysaccharide biosynthetic process
ICN77_RS05715	COG1187	pseudouridine synthase activity
ICN77_RS05725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICN77_RS05730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ICN77_RS05735	COG0510	thiamine kinase activity
ICN77_RS05740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ICN77_RS05750	COG1363	Peptidase, m42
ICN77_RS05755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ICN77_RS05760	COG4848	Belongs to the UPF0354 family
ICN77_RS05765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICN77_RS05770	COG1674	ftsk spoiiie
ICN77_RS05775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ICN77_RS05780	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ICN77_RS05790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ICN77_RS05790	COG1605	Chorismate mutase
ICN77_RS05795	COG1609	Transcriptional regulator
ICN77_RS05800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ICN77_RS05810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ICN77_RS05815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ICN77_RS05820	COG0204	Acyl-transferase
ICN77_RS05825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ICN77_RS05825	COG1263	PTS System
ICN77_RS05835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ICN77_RS05840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ICN77_RS05845	COG1764	response to oxidative stress
ICN77_RS05850	COG0584	glycerophosphoryl diester phosphodiesterase
ICN77_RS05855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ICN77_RS05860	COG1956	GAF domain-containing protein
ICN77_RS05865	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ICN77_RS05875	COG0301	tRNA thio-modification
ICN77_RS05885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ICN77_RS05890	COG0827	DNA restriction-modification system
ICN77_RS05895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ICN77_RS05905	COG0589	response to stress
ICN77_RS05910	COG0686	Belongs to the AlaDH PNT family
ICN77_RS05915	COG0006	proline dipeptidase activity
ICN77_RS05920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ICN77_RS05940	COG4109	DRTGG domain
ICN77_RS05945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ICN77_RS05950	COG0587	DNA-directed DNA polymerase activity
ICN77_RS05955	COG0281	malic enzyme
ICN77_RS05960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ICN77_RS05965	COG0825	malonyl-CoA metabolic process
ICN77_RS05970	COG0205	6-phosphofructokinase activity
ICN77_RS05975	COG0469	pyruvate kinase activity
ICN77_RS05980	COG1113	amino acid transport
ICN77_RS05985	COG0372	Belongs to the citrate synthase family
ICN77_RS05990	COG0538	isocitrate dehydrogenase activity
ICN77_RS05995	COG0745	RESPONSE REGULATOR receiver
ICN77_RS06000	COG5002	protein histidine kinase activity
ICN77_RS06005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICN77_RS06005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICN77_RS06010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ICN77_RS06015	COG0237	dephospho-CoA kinase activity
ICN77_RS06025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ICN77_RS06035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ICN77_RS06040	COG3611	Membrane attachment protein
ICN77_RS06045	COG1484	DNA-dependent DNA replication
ICN77_RS06050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ICN77_RS06055	COG0833	amino acid
ICN77_RS06060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ICN77_RS06065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ICN77_RS06070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ICN77_RS06075	COG4112	unkown
ICN77_RS06085	COG0544	peptidyl-prolyl cis-trans isomerase activity
ICN77_RS06090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ICN77_RS06095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ICN77_RS06100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ICN77_RS06110	COG0181	hydroxymethylbilane synthase activity
ICN77_RS06120	COG0113	porphobilinogen synthase activity
ICN77_RS06125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ICN77_RS06135	COG2818	Glycosylase
ICN77_RS06140	COG0525	valine-tRNA ligase activity
ICN77_RS06145	COG0285	dihydrofolate synthase activity
ICN77_RS06155	COG2003	Belongs to the UPF0758 family
ICN77_RS06185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ICN77_RS06190	COG2868	ribosomal protein
ICN77_RS06195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ICN77_RS06200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ICN77_RS06205	COG4492	Belongs to the UPF0735 family
ICN77_RS06210	COG0632	four-way junction helicase activity
ICN77_RS06215	COG2255	four-way junction helicase activity
ICN77_RS06220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ICN77_RS06225	COG0343	queuine tRNA-ribosyltransferase activity
ICN77_RS06230	COG1862	Preprotein translocase
ICN77_RS06235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ICN77_RS06235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ICN77_RS06240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ICN77_RS06240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ICN77_RS06245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ICN77_RS06250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ICN77_RS06255	COG1490	D-aminoacyl-tRNA deacylase activity
ICN77_RS06260	COG0860	N-Acetylmuramoyl-L-alanine amidase
ICN77_RS06265	COG0124	histidyl-tRNA synthetase
ICN77_RS06270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ICN77_RS06280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ICN77_RS06285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ICN77_RS06290	COG1959	2 iron, 2 sulfur cluster binding
ICN77_RS06300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ICN77_RS06305	COG1104	cysteine desulfurase activity
ICN77_RS06310	COG0482	sulfurtransferase activity
ICN77_RS06320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ICN77_RS06325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ICN77_RS06330	COG4472	Bacterial protein of unknown function (DUF965)
ICN77_RS06335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ICN77_RS06340	COG3906	Belongs to the UPF0473 family
ICN77_RS06350	COG0826	peptidase U32
ICN77_RS06355	COG0826	peptidase U32
ICN77_RS06360	COG0572	uridine kinase
ICN77_RS06365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ICN77_RS06375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ICN77_RS06380	COG1984	allophanate hydrolase subunit 2
ICN77_RS06385	COG0511	ligase activity, forming carbon-carbon bonds
ICN77_RS06390	COG0439	Biotin carboxylase
ICN77_RS06395	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ICN77_RS06400	COG1914	H( )-stimulated, divalent metal cation uptake system
ICN77_RS06405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ICN77_RS06410	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ICN77_RS06415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ICN77_RS06420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ICN77_RS06425	COG1534	Rna-binding protein
ICN77_RS06430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ICN77_RS06435	COG1713	HD superfamily hydrolase involved in NAD metabolism
ICN77_RS06440	COG0799	negative regulation of ribosome biogenesis
ICN77_RS06445	COG2226	methyltransferase
ICN77_RS06455	COG2131	deaminase
ICN77_RS06460	COG2333	competence protein COMEC
ICN77_RS06460	COG0658	competence protein
ICN77_RS06465	COG1466	dna polymerase III delta subunit
ICN77_RS06470	COG0268	Binds directly to 16S ribosomal RNA
ICN77_RS06475	COG0481	GTPase activity
ICN77_RS06480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ICN77_RS06485	COG1420	regulation of RNA biosynthetic process
ICN77_RS06490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ICN77_RS06495	COG0443	Heat shock 70 kDa protein
ICN77_RS06500	COG0484	heat shock protein binding
ICN77_RS06505	COG2264	protein methyltransferase activity
ICN77_RS06510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ICN77_RS06515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ICN77_RS06525	COG1030	water channel activity
ICN77_RS06530	COG4864	UPF0365 protein
ICN77_RS06540	COG1702	phosphate starvation-inducible protein PhoH
ICN77_RS06545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ICN77_RS06550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ICN77_RS06555	COG0295	cytidine deaminase activity
ICN77_RS06560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ICN77_RS06565	COG1381	Involved in DNA repair and RecF pathway recombination
ICN77_RS06570	COG0423	glycine-tRNA ligase activity
ICN77_RS06575	COG0517	IMP dehydrogenase activity
ICN77_RS06580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ICN77_RS06585	COG0358	DNA primase activity
ICN77_RS06590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ICN77_RS06595	COG2384	SAM-dependent methyltransferase
ICN77_RS06600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ICN77_RS06605	COG0513	Belongs to the DEAD box helicase family
ICN77_RS06610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ICN77_RS06615	COG1121	(ABC) transporter
ICN77_RS06620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ICN77_RS06625	COG0735	belongs to the Fur family
ICN77_RS06630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ICN77_RS06635	COG0768	penicillin binding
ICN77_RS06640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ICN77_RS06645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ICN77_RS06655	COG4483	Protein conserved in bacteria
ICN77_RS06660	COG1940	carbohydrate kinase activity
ICN77_RS06665	COG0011	TIGRFAM Protein of
ICN77_RS06675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ICN77_RS06680	COG1459	type II secretion system
ICN77_RS06685	COG4537	Required for transformation and DNA binding
ICN77_RS06705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ICN77_RS06710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ICN77_RS06715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ICN77_RS06720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ICN77_RS06730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ICN77_RS06735	COG0095	Lipoate-protein ligase
ICN77_RS06750	COG0006	proline dipeptidase activity
ICN77_RS06755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ICN77_RS06760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ICN77_RS06765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ICN77_RS06770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ICN77_RS06775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ICN77_RS06780	COG0511	ligase activity, forming carbon-carbon bonds
ICN77_RS06785	COG0439	Biotin carboxylase
ICN77_RS06790	COG1302	Protein conserved in bacteria
ICN77_RS06795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ICN77_RS06800	COG1570	exodeoxyribonuclease VII activity
ICN77_RS06805	COG1722	exodeoxyribonuclease VII activity
ICN77_RS06815	COG1438	arginine binding
ICN77_RS06820	COG0497	DNA recombination
ICN77_RS06825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ICN77_RS06830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ICN77_RS06835	COG0022	dehydrogenase e1 component
ICN77_RS06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICN77_RS06850	COG4129	membrane
ICN77_RS06860	COG2195	Cleaves the N-terminal amino acid of tripeptides
ICN77_RS06865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ICN77_RS06870	COG0366	Alpha amylase catalytic
ICN77_RS06880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICN77_RS06885	COG1234	tRNA 3'-trailer cleavage
ICN77_RS06890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ICN77_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS06900	COG0667	Aldo Keto reductase
ICN77_RS06905	COG0494	nUDIX hydrolase
ICN77_RS06910	COG0735	belongs to the Fur family
ICN77_RS06915	COG4974	Belongs to the 'phage' integrase family
ICN77_RS06920	COG1547	Domain of unknown function (DUF309)
ICN77_RS06925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ICN77_RS06930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ICN77_RS06935	COG1187	pseudouridine synthase activity
ICN77_RS06940	COG0745	RESPONSE REGULATOR receiver
ICN77_RS06955	COG1141	Ferredoxin
ICN77_RS06965	COG0514	ATP-dependent DNA helicase (RecQ)
ICN77_RS06970	COG1388	LysM domain
ICN77_RS06975	COG0492	ferredoxin-NADP+ reductase activity
ICN77_RS06980	COG0252	asparaginase activity
ICN77_RS06985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ICN77_RS06990	COG0539	negative regulation of cytoplasmic translation
ICN77_RS06995	COG1160	GTP binding
ICN77_RS07000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ICN77_RS07015	COG2226	methyltransferase
ICN77_RS07025	COG0105	UTP biosynthetic process
ICN77_RS07030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ICN77_RS07035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ICN77_RS07040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ICN77_RS07050	COG5582	Belongs to the UPF0302 family
ICN77_RS07055	COG4347	Protein of unknown function (DUF1405)
ICN77_RS07060	COG2738	Putative neutral zinc metallopeptidase
ICN77_RS07065	COG1694	Mazg nucleotide pyrophosphohydrolase
ICN77_RS07070	COG0438	transferase activity, transferring glycosyl groups
ICN77_RS07075	COG0617	tRNA 3'-terminal CCA addition
ICN77_RS07080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ICN77_RS07080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ICN77_RS07085	COG1199	ATP-dependent helicase activity
ICN77_RS07085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ICN77_RS07090	COG0017	Asparaginyl-tRNA synthetase
ICN77_RS07095	COG3935	DnaD domain protein
ICN77_RS07100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ICN77_RS07110	COG4499	WXG100 protein secretion system (Wss), protein YukC
ICN77_RS07110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ICN77_RS07115	COG3331	DNA recombination
ICN77_RS07125	COG4474	Belongs to the UPF0398 family
ICN77_RS07130	COG3599	regulation of cell shape
ICN77_RS07140	COG0116	Belongs to the methyltransferase superfamily
ICN77_RS07150	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ICN77_RS07155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICN77_RS07175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ICN77_RS07185	COG1413	lyase activity
ICN77_RS07200	COG1136	(ABC) transporter
ICN77_RS07225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ICN77_RS07230	COG2190	(PTS) system
ICN77_RS07235	COG4479	Belongs to the UPF0346 family
ICN77_RS07240	COG0793	Belongs to the peptidase S41A family
ICN77_RS07250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ICN77_RS07255	COG0671	phosphoesterase, PA-phosphatase related
ICN77_RS07260	COG3842	ATPase activity
ICN77_RS07265	COG4209	transmembrane transport
ICN77_RS07275	COG0395	ABC-type sugar transport system, permease component
ICN77_RS07285	COG0534	Mate efflux family protein
ICN77_RS07290	COG1349	DNA-binding transcription factor activity
ICN77_RS07295	COG0745	RESPONSE REGULATOR receiver
ICN77_RS07300	COG5002	protein histidine kinase activity
ICN77_RS07305	COG0567	Dehydrogenase, E1 component
ICN77_RS07310	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICN77_RS07320	COG1131	(ABC) transporter
ICN77_RS07340	COG0714	Associated with various cellular activities
ICN77_RS07345	COG4548	von Willebrand factor, type A
ICN77_RS07350	COG1114	Component of the transport system for branched-chain amino acids
ICN77_RS07355	COG3853	Toxic anion resistance protein (TelA)
ICN77_RS07365	COG1254	Belongs to the acylphosphatase family
ICN77_RS07375	COG1278	Cold shock
ICN77_RS07390	COG1131	(ABC) transporter
ICN77_RS07410	COG1473	amidohydrolase
ICN77_RS07415	COG2171	N-acyltransferase activity
ICN77_RS07420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ICN77_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ICN77_RS07430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ICN77_RS07435	COG0527	aspartate kinase activity
ICN77_RS07440	COG0488	(ABC) transporter
ICN77_RS07445	COG2996	Protein conserved in bacteria
ICN77_RS07450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ICN77_RS07455	COG0573	inorganic phosphate transmembrane transporter activity
ICN77_RS07460	COG0581	inorganic phosphate transmembrane transporter activity
ICN77_RS07465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ICN77_RS07470	COG0704	Plays a role in the regulation of phosphate uptake
ICN77_RS07505	COG4607	ABC-type enterochelin transport system periplasmic component
ICN77_RS07515	COG2348	transferase activity, transferring amino-acyl groups
ICN77_RS07520	COG2348	transferase activity, transferring amino-acyl groups
ICN77_RS07530	COG0159	tryptophan synthase activity
ICN77_RS07535	COG0133	tryptophan synthase activity
ICN77_RS07540	COG0135	phosphoribosylanthranilate isomerase activity
ICN77_RS07545	COG0134	indole-3-glycerol-phosphate synthase activity
ICN77_RS07555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ICN77_RS07555	COG0512	Glutamine amidotransferase of anthranilate synthase
ICN77_RS07560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ICN77_RS07565	COG0287	Prephenate dehydrogenase
ICN77_RS07570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ICN77_RS07575	COG1942	4-Oxalocrotonate Tautomerase
ICN77_RS07590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ICN77_RS07590	COG0392	lysyltransferase activity
ICN77_RS07595	COG0628	permease
ICN77_RS07600	COG3711	transcriptional antiterminator
ICN77_RS07610	COG1115	amino acid carrier protein
ICN77_RS07615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICN77_RS07620	COG0187	DNA topoisomerase II activity
ICN77_RS07625	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ICN77_RS07630	COG4841	protein insertion into membrane
ICN77_RS07635	COG0824	Thioesterase
ICN77_RS07640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ICN77_RS07645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ICN77_RS07650	COG1970	mechanosensitive ion channel activity
ICN77_RS07655	COG0419	ATPase involved in DNA repair
ICN77_RS07660	COG0420	3'-5' exonuclease activity
ICN77_RS07665	COG4846	Membrane protein involved in cytochrome C biogenesis
ICN77_RS07675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ICN77_RS07680	COG4224	UPF0291 protein
ICN77_RS07690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ICN77_RS07695	COG2340	Cysteine-rich secretory protein family
ICN77_RS07700	COG0516	GMP reductase activity
ICN77_RS07705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ICN77_RS07715	COG0753	catalase activity
ICN77_RS07720	COG0833	amino acid
ICN77_RS07735	COG0083	homoserine kinase activity
ICN77_RS07740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ICN77_RS07745	COG0460	homoserine dehydrogenase
ICN77_RS07750	COG0527	aspartate kinase activity
ICN77_RS07765	COG1525	nuclease
ICN77_RS07775	COG2197	response regulator
ICN77_RS07780	COG4585	Histidine kinase
ICN77_RS07790	COG1131	(ABC) transporter
ICN77_RS07795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICN77_RS07835	COG0174	glutamine synthetase
ICN77_RS07840	COG0789	Transcriptional regulator
ICN77_RS07845	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ICN77_RS07850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ICN77_RS07855	COG0386	Belongs to the glutathione peroxidase family
ICN77_RS07860	COG1923	regulation of RNA biosynthetic process
ICN77_RS07865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ICN77_RS07875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ICN77_RS07880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ICN77_RS07885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ICN77_RS07890	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ICN77_RS07895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ICN77_RS07900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ICN77_RS07910	COG4550	Control of competence regulator ComK, YlbF/YmcA
ICN77_RS07915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ICN77_RS07925	COG4195	phage-related replication protein
ICN77_RS07930	COG1013	pyruvate-flavodoxin oxidoreductase activity
ICN77_RS07935	COG0674	pyruvate-flavodoxin oxidoreductase activity
ICN77_RS07935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ICN77_RS07940	COG1692	metallophosphoesterase
ICN77_RS07960	COG1418	mRNA catabolic process
ICN77_RS07965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ICN77_RS07970	COG1546	Belongs to the CinA family
ICN77_RS07970	COG1058	Belongs to the CinA family
ICN77_RS07975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ICN77_RS07990	COG0300	oxidoreductase activity
ICN77_RS07995	COG0612	Peptidase, M16
ICN77_RS08000	COG0612	Peptidase, M16
ICN77_RS08005	COG2188	Transcriptional regulator
ICN77_RS08010	COG1674	ftsk spoiiie
ICN77_RS08015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ICN77_RS08020	COG1185	polyribonucleotide nucleotidyltransferase activity
ICN77_RS08025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ICN77_RS08030	COG0196	riboflavin kinase activity
ICN77_RS08035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ICN77_RS08040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ICN77_RS08045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ICN77_RS08050	COG1358	cellular component organization or biogenesis
ICN77_RS08055	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ICN77_RS08060	COG0195	Participates in both transcription termination and antitermination
ICN77_RS08065	COG0779	Required for maturation of 30S ribosomal subunits
ICN77_RS08070	COG2176	DNA-directed DNA polymerase activity
ICN77_RS08075	COG0442	prolyl-tRNA aminoacylation
ICN77_RS08085	COG4589	Belongs to the CDS family
ICN77_RS08090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ICN77_RS08095	COG0233	cytoplasmic translational termination
ICN77_RS08100	COG0528	UMP kinase activity
ICN77_RS08105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ICN77_RS08110	COG0052	Belongs to the universal ribosomal protein uS2 family
ICN77_RS08115	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ICN77_RS08120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ICN77_RS08125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ICN77_RS08130	COG4974	Belongs to the 'phage' integrase family
ICN77_RS08135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ICN77_RS08140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ICN77_RS08145	COG0758	DNA mediated transformation
ICN77_RS08150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ICN77_RS08155	COG0045	succinate-CoA ligase (ADP-forming) activity
ICN77_RS08160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ICN77_RS08170	COG4485	Bacterial membrane protein, YfhO
ICN77_RS08180	COG0335	large ribosomal subunit rRNA binding
ICN77_RS08185	COG0336	Belongs to the RNA methyltransferase TrmD family
ICN77_RS08190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ICN77_RS08195	COG0228	four-way junction DNA binding
ICN77_RS08200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ICN77_RS08205	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ICN77_RS08210	COG0552	protein localization to endoplasmic reticulum
ICN77_RS08215	COG1196	nuclear chromosome segregation
ICN77_RS08220	COG0571	ribonuclease III activity
ICN77_RS08225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ICN77_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS08240	COG0416	fatty acid biosynthetic process
ICN77_RS08245	COG1349	DNA-binding transcription factor activity
ICN77_RS08250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ICN77_RS08255	COG1461	Dihydroxyacetone kinase
ICN77_RS08260	COG1302	Protein conserved in bacteria
ICN77_RS08265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ICN77_RS08275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ICN77_RS08280	COG1162	GTPase activity
ICN77_RS08290	COG0631	protein serine/threonine phosphatase activity
ICN77_RS08295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ICN77_RS08300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ICN77_RS08300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ICN77_RS08305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ICN77_RS08310	COG0242	peptide deformylase activity
ICN77_RS08320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ICN77_RS08325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ICN77_RS08330	COG1758	RNA polymerase activity
ICN77_RS08335	COG0194	GDP metabolic process
ICN77_RS08355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ICN77_RS08360	COG0284	orotidine-5'-phosphate decarboxylase activity
ICN77_RS08365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ICN77_RS08370	COG0505	Belongs to the CarA family
ICN77_RS08375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ICN77_RS08380	COG0540	Belongs to the ATCase OTCase family
ICN77_RS08385	COG2233	PERMEase
ICN77_RS08390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ICN77_RS08395	COG0564	pseudouridine synthase activity
ICN77_RS08400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ICN77_RS08405	COG3942	CHAP domain
ICN77_RS08405	COG1388	LysM domain
ICN77_RS08415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ICN77_RS08420	COG3599	regulation of cell shape
ICN77_RS08430	COG0762	integral membrane protein
ICN77_RS08435	COG1799	cell septum assembly
ICN77_RS08440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ICN77_RS08445	COG1496	oxidoreductase activity
ICN77_RS08465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ICN77_RS08470	COG0849	cell division
ICN77_RS08475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ICN77_RS08480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ICN77_RS08485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ICN77_RS08490	COG0768	penicillin binding
ICN77_RS08495	COG4839	cell division protein FtsL
ICN77_RS08500	COG0275	rRNA processing
ICN77_RS08505	COG2001	Belongs to the MraZ family
ICN77_RS08510	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ICN77_RS08515	COG0454	-acetyltransferase
ICN77_RS08520	COG1011	Hydrolase
ICN77_RS08555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ICN77_RS08560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ICN77_RS08565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ICN77_RS08570	COG1053	succinate dehydrogenase
ICN77_RS08575	COG2009	succinate dehydrogenase
ICN77_RS08580	COG0322	excinuclease ABC activity
ICN77_RS08585	COG3118	belongs to the thioredoxin family
ICN77_RS08590	COG1193	negative regulation of DNA recombination
ICN77_RS08595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ICN77_RS08595	COG1796	DNA polymerase
ICN77_RS08605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ICN77_RS08610	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ICN77_RS08615	COG0072	phenylalanine-tRNA ligase activity
ICN77_RS08615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICN77_RS08620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ICN77_RS08625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ICN77_RS08635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ICN77_RS08645	COG1323	Belongs to the UPF0348 family
ICN77_RS08650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ICN77_RS08655	COG0742	ribosomal rna small subunit methyltransferase
ICN77_RS08665	COG4471	UPF0298 protein
ICN77_RS08670	COG0584	glycerophosphoryl diester phosphodiesterase
ICN77_RS08675	COG3679	Belongs to the UPF0342 family
ICN77_RS08680	COG2340	Cysteine-rich secretory protein family
ICN77_RS08690	COG0109	protoheme IX farnesyltransferase activity
ICN77_RS08695	COG1612	heme a metabolic process
ICN77_RS08705	COG0772	Belongs to the SEDS family
ICN77_RS08710	COG4838	Belongs to the UPF0358 family
ICN77_RS08715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ICN77_RS08720	COG4896	Protein conserved in bacteria
ICN77_RS08740	COG1217	gtp-binding protein TYPA
ICN77_RS08750	COG0483	inositol monophosphate 1-phosphatase activity
ICN77_RS08755	COG4493	Belongs to the UPF0637 family
ICN77_RS08760	COG1914	H( )-stimulated, divalent metal cation uptake system
ICN77_RS08785	COG1176	ABC-type spermidine putrescine transport system, permease component I
ICN77_RS08790	COG3842	ATPase activity
ICN77_RS08800	COG4476	Belongs to the UPF0223 family
ICN77_RS08810	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICN77_RS08815	COG0022	dehydrogenase e1 component
ICN77_RS08820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ICN77_RS08830	COG0242	peptide deformylase activity
ICN77_RS08835	COG5503	Protein of unknown function (DUF1447)
ICN77_RS08840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ICN77_RS08845	COG0569	domain protein
ICN77_RS08850	COG1294	oxidase, subunit
ICN77_RS08855	COG1271	oxidase subunit
ICN77_RS08875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICN77_RS08880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICN77_RS08890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ICN77_RS08905	COG4716	Myosin-crossreactive antigen
ICN77_RS08915	COG4172	Belongs to the ABC transporter superfamily
ICN77_RS08920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ICN77_RS08925	COG0151	Belongs to the GarS family
ICN77_RS08930	COG0138	bifunctional purine biosynthesis protein purh
ICN77_RS08935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ICN77_RS08940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ICN77_RS08945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ICN77_RS08950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICN77_RS08955	COG0047	phosphoribosylformylglycinamidine synthase activity
ICN77_RS08960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICN77_RS08965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ICN77_RS08970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ICN77_RS08975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ICN77_RS08980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ICN77_RS08990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ICN77_RS08995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ICN77_RS09000	COG1845	cytochrome c oxidase, subunit III
ICN77_RS09005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ICN77_RS09020	COG1316	TRANSCRIPTIONal
ICN77_RS09045	COG3594	Acyltransferase
ICN77_RS09050	COG0436	Aminotransferase
ICN77_RS09055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ICN77_RS09065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ICN77_RS09070	COG1169	isochorismate synthase
ICN77_RS09075	COG1575	Belongs to the MenA family. Type 1 subfamily
ICN77_RS09080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ICN77_RS09085	COG2314	TM2 domain
ICN77_RS09145	COG4873	Protein conserved in bacteria
ICN77_RS09155	COG0737	Belongs to the 5'-nucleotidase family
ICN77_RS09160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ICN77_RS09165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ICN77_RS09170	COG0861	Integral membrane protein TerC family
ICN77_RS09175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ICN77_RS09185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ICN77_RS09190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ICN77_RS09195	COG2814	Major facilitator Superfamily
ICN77_RS09200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ICN77_RS09205	COG2382	esterase
ICN77_RS09210	COG0628	permease
ICN77_RS09255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICN77_RS09260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICN77_RS09300	COG0475	glutathione-regulated potassium exporter activity
ICN77_RS09300	COG0569	domain protein
ICN77_RS09305	COG2239	Acts as a magnesium transporter
ICN77_RS09310	COG0564	pseudouridine synthase activity
ICN77_RS09315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ICN77_RS09320	COG2357	RelA SpoT domain protein
ICN77_RS09335	COG2346	COG2346, Truncated hemoglobins
ICN77_RS09340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ICN77_RS09345	COG1164	Oligoendopeptidase f
ICN77_RS09355	COG4862	establishment of competence for transformation
ICN77_RS09360	COG1393	Belongs to the ArsC family
ICN77_RS09365	COG0180	Tryptophanyl-tRNA synthetase
ICN77_RS09370	COG4166	transmembrane transport
ICN77_RS09375	COG4608	Belongs to the ABC transporter superfamily
ICN77_RS09380	COG0444	Belongs to the ABC transporter superfamily
ICN77_RS09385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ICN77_RS09405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ICN77_RS09420	COG0542	response to heat
ICN77_RS09435	COG0561	phosphatase activity
ICN77_RS09440	COG0446	pyridine nucleotide-disulphide oxidoreductase
ICN77_RS09460	COG0179	Fumarylacetoacetate (FAA) hydrolase
ICN77_RS09465	COG1074	ATP-dependent DNA helicase activity
ICN77_RS09470	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ICN77_RS09490	COG0166	Belongs to the GPI family
ICN77_RS09495	COG0137	argininosuccinate synthase activity
ICN77_RS09500	COG0165	Argininosuccinate lyase
ICN77_RS09505	COG0584	glycerophosphoryl diester phosphodiesterase
ICN77_RS09515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ICN77_RS09530	COG1902	pentaerythritol trinitrate reductase activity
ICN77_RS09535	COG1098	S1 RNA binding domain
ICN77_RS09540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ICN77_RS09550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ICN77_RS09550	COG2111	Na H antiporter
ICN77_RS09555	COG2111	Na H antiporter
ICN77_RS09560	COG1006	Multisubunit Na H antiporter MnhC subunit
ICN77_RS09565	COG0651	ATP synthesis coupled electron transport
ICN77_RS09570	COG1863	multisubunit Na H antiporter MnhE subunit
ICN77_RS09575	COG2212	antiporter activity
ICN77_RS09580	COG1320	monovalent cation:proton antiporter activity
ICN77_RS09590	COG2050	protein possibly involved in aromatic compounds catabolism
ICN77_RS09595	COG2056	Na+-H+ antiporter family
ICN77_RS09600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ICN77_RS09605	COG1252	NADH dehydrogenase
ICN77_RS09610	COG0316	Belongs to the HesB IscA family
ICN77_RS09615	COG4844	belongs to the
ICN77_RS09620	COG1252	NADH dehydrogenase
ICN77_RS09625	COG4837	Protein of unknown function (DUF1462)
ICN77_RS09630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ICN77_RS09635	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ICN77_RS09640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ICN77_RS09645	COG1696	Membrane protein involved in D-alanine export
ICN77_RS09650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ICN77_RS09660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICN77_RS09665	COG0647	UMP catabolic process
ICN77_RS09670	COG2445	Protein of unknown function DUF86
ICN77_RS09680	COG4470	Protein conserved in bacteria
ICN77_RS09685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ICN77_RS09690	COG0737	Belongs to the 5'-nucleotidase family
ICN77_RS09695	COG0730	response to heat
ICN77_RS09700	COG1801	Protein of unknown function DUF72
ICN77_RS09705	COG1253	flavin adenine dinucleotide binding
ICN77_RS09720	COG5632	N-Acetylmuramoyl-L-alanine amidase
ICN77_RS09720	COG1388	LysM domain
ICN77_RS09745	COG4195	phage-related replication protein
ICN77_RS09870	COG0756	dUTP diphosphatase activity
ICN77_RS09915	COG1484	DNA-dependent DNA replication
ICN77_RS10015	COG4974	Belongs to the 'phage' integrase family
ICN77_RS10020	COG0719	Fe-S assembly protein
ICN77_RS10025	COG0822	iron-sulfur transferase activity
ICN77_RS10030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ICN77_RS10035	COG0719	Fe-S assembly protein
ICN77_RS10040	COG0396	ATPase activity
ICN77_RS10050	COG3237	CsbD-like
ICN77_RS10060	COG1464	Belongs to the NlpA lipoprotein family
ICN77_RS10065	COG2011	ABC-type metal ion transport system permease component
ICN77_RS10070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ICN77_RS10080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ICN77_RS10085	COG0509	glycine decarboxylation via glycine cleavage system
ICN77_RS10090	COG1393	Belongs to the ArsC family
ICN77_RS10095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ICN77_RS10105	COG0710	3-dehydroquinate dehydratase activity
ICN77_RS10110	COG1764	response to oxidative stress
ICN77_RS10160	COG4195	phage-related replication protein
ICN77_RS10175	COG1278	Cold shock
ICN77_RS10205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ICN77_RS10245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ICN77_RS10250	COG0557	exoribonuclease II activity
ICN77_RS10255	COG1647	Serine aminopeptidase, S33
ICN77_RS10260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ICN77_RS10270	COG0148	phosphopyruvate hydratase activity
ICN77_RS10275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ICN77_RS10280	COG0149	triose-phosphate isomerase activity
ICN77_RS10285	COG0126	phosphoglycerate kinase activity
ICN77_RS10290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ICN77_RS10310	COG1090	epimerase
ICN77_RS10320	COG0740	serine-type endopeptidase activity
ICN77_RS10330	COG1481	regulation of sporulation
ICN77_RS10335	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ICN77_RS10340	COG1660	Displays ATPase and GTPase activities
ICN77_RS10345	COG0492	ferredoxin-NADP+ reductase activity
ICN77_RS10360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ICN77_RS10365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ICN77_RS10370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ICN77_RS10375	COG0556	nucleotide-excision repair
ICN77_RS10390	COG3942	CHAP domain
ICN77_RS10390	COG1388	LysM domain
ICN77_RS10400	COG0653	protein targeting
ICN77_RS10405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ICN77_RS10410	COG1040	competence protein
ICN77_RS10425	COG1739	Uncharacterized protein family UPF0029
ICN77_RS10430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ICN77_RS10435	COG2199	diguanylate cyclase activity
ICN77_RS10450	COG2195	Cleaves the N-terminal amino acid of tripeptides
ICN77_RS10455	COG1929	Belongs to the glycerate kinase type-1 family
ICN77_RS10475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ICN77_RS10490	COG4604	ABC transporter, ATP-binding protein
ICN77_RS10495	COG4605	iron ion homeostasis
ICN77_RS10500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICN77_RS10510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICN77_RS10515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICN77_RS10520	COG1780	Probably involved in ribonucleotide reductase function
ICN77_RS10530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ICN77_RS10535	COG3104	oligopeptide transport
ICN77_RS10545	COG1597	lipid kinase activity
ICN77_RS10550	COG1012	belongs to the aldehyde dehydrogenase family
ICN77_RS10550	COG1454	alcohol dehydrogenase
ICN77_RS10555	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ICN77_RS10560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ICN77_RS10565	COG1174	glycine betaine transport
ICN77_RS10575	COG0514	ATP-dependent DNA helicase (RecQ)
ICN77_RS10580	COG0488	(ABC) transporter
ICN77_RS10600	COG1368	sulfuric ester hydrolase activity
ICN77_RS10610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ICN77_RS10625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ICN77_RS10635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ICN77_RS10640	COG0720	synthase
ICN77_RS10645	COG0602	queuosine metabolic process
ICN77_RS10665	COG0745	RESPONSE REGULATOR receiver
ICN77_RS10670	COG5002	protein histidine kinase activity
ICN77_RS10675	COG0463	Glycosyl transferase, family 2
ICN77_RS10680	COG0656	L-ascorbic acid biosynthetic process
ICN77_RS10685	COG1253	flavin adenine dinucleotide binding
ICN77_RS10690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ICN77_RS10695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ICN77_RS10695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ICN77_RS10695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICN77_RS10700	COG1105	Belongs to the carbohydrate kinase PfkB family
ICN77_RS10705	COG1349	DNA-binding transcription factor activity
ICN77_RS10710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ICN77_RS10735	COG0415	Belongs to the DNA photolyase family
ICN77_RS10740	COG0471	metal ion transport
ICN77_RS10745	COG0039	L-malate dehydrogenase activity
ICN77_RS10765	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ICN77_RS10770	COG4988	ABC transporter
ICN77_RS10775	COG1968	undecaprenyl-diphosphatase activity
ICN77_RS10790	COG1671	Belongs to the UPF0178 family
ICN77_RS10795	COG1611	Belongs to the LOG family
ICN77_RS10820	COG2839	Protein conserved in bacteria
ICN77_RS10825	COG2814	Major facilitator Superfamily
ICN77_RS10830	COG0583	DNA-binding transcription factor activity
ICN77_RS10850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ICN77_RS10860	COG0217	transcriptional regulatory protein
ICN77_RS10880	COG1388	LysM domain
ICN77_RS10880	COG3942	CHAP domain
ICN77_RS10885	COG0306	phosphate transporter
ICN77_RS10890	COG1392	Phosphate transport regulator
ICN77_RS10895	COG0577	efflux transmembrane transporter activity
ICN77_RS10900	COG1136	(ABC) transporter
ICN77_RS10905	COG2205	protein histidine kinase activity
ICN77_RS10910	COG0745	RESPONSE REGULATOR receiver
ICN77_RS10915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ICN77_RS10930	COG3949	Membrane
ICN77_RS10940	COG1120	ATPase activity
ICN77_RS10945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ICN77_RS10950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ICN77_RS10955	COG1132	(ABC) transporter
ICN77_RS10960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ICN77_RS10970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ICN77_RS10975	COG1682	transport, permease protein
ICN77_RS10980	COG1134	teichoic acid transport
ICN77_RS10985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ICN77_RS10995	COG1321	iron dependent repressor
ICN77_RS11000	COG1121	(ABC) transporter
ICN77_RS11005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ICN77_RS11010	COG0803	Belongs to the bacterial solute-binding protein 9 family
ICN77_RS11020	COG1320	monovalent cation:proton antiporter activity
ICN77_RS11025	COG2212	antiporter activity
ICN77_RS11030	COG1863	multisubunit Na H antiporter MnhE subunit
ICN77_RS11035	COG0651	ATP synthesis coupled electron transport
ICN77_RS11040	COG1006	Multisubunit Na H antiporter MnhC subunit
ICN77_RS11045	COG2111	Na H antiporter
ICN77_RS11050	COG2111	Na H antiporter
ICN77_RS11050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ICN77_RS11080	COG0596	Alpha beta hydrolase
ICN77_RS11100	COG0546	phosphoglycolate phosphatase activity
ICN77_RS11105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICN77_RS11110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ICN77_RS11120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ICN77_RS11125	COG0018	arginyl-trna synthetase
ICN77_RS11140	COG1064	alcohol dehydrogenase
ICN77_RS11145	COG3875	lactate racemase activity
ICN77_RS11150	COG1606	tRNA processing
ICN77_RS11155	COG1691	(AIR) carboxylase
ICN77_RS11160	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ICN77_RS11170	COG1078	dGTPase activity
ICN77_RS11180	COG0667	Aldo Keto reductase
ICN77_RS11190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ICN77_RS11195	COG4844	belongs to the
ICN77_RS11215	COG0095	Lipoate-protein ligase
ICN77_RS11220	COG0280	phosphate acetyltransferase
ICN77_RS11225	COG3253	May function as heme-dependent peroxidase
ICN77_RS11250	COG0531	amino acid
ICN77_RS11255	COG2363	Small membrane protein
ICN77_RS11265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ICN77_RS11275	COG0351	phosphomethylpyrimidine kinase
ICN77_RS11300	COG0183	Belongs to the thiolase family
ICN77_RS11305	COG0318	PFAM AMP-dependent synthetase and ligase
ICN77_RS11315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ICN77_RS11320	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ICN77_RS11325	COG0363	glucosamine-6-phosphate deaminase activity
ICN77_RS11335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ICN77_RS11340	COG1469	GTP cyclohydrolase I activity
ICN77_RS11365	COG0431	NADPH-dependent FMN reductase
ICN77_RS11370	COG0561	phosphatase activity
ICN77_RS11380	COG1428	Deoxynucleoside kinase
ICN77_RS11385	COG1428	Deoxynucleoside kinase
ICN77_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
ICN77_RS11400	COG0546	phosphoglycolate phosphatase activity
ICN77_RS11405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ICN77_RS11410	COG1063	alcohol dehydrogenase
ICN77_RS11415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ICN77_RS11420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ICN77_RS11425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ICN77_RS11445	COG1473	amidohydrolase
ICN77_RS11450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ICN77_RS11455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ICN77_RS11465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ICN77_RS11475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ICN77_RS11480	COG0085	RNA polymerase activity
ICN77_RS11485	COG2813	Specifically methylates the guanine in position
ICN77_RS11490	COG0222	ribosome binding
ICN77_RS11495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ICN77_RS11500	COG0081	regulation of translation
ICN77_RS11505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ICN77_RS11510	COG0250	Participates in transcription elongation, termination and antitermination
ICN77_RS11515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ICN77_RS11520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ICN77_RS11530	COG3688	RNA-binding protein containing a PIN domain
ICN77_RS11535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ICN77_RS11540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ICN77_RS11545	COG0215	cysteine-tRNA ligase activity
ICN77_RS11550	COG1045	serine acetyltransferase
ICN77_RS11555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ICN77_RS11560	COG4956	integral membrane protein (PIN domain superfamily)
ICN77_RS11565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ICN77_RS11570	COG0542	response to heat
ICN77_RS11575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ICN77_RS11580	COG3880	PFAM UvrB UvrC protein
ICN77_RS11585	COG4463	regulation of RNA biosynthetic process
ICN77_RS11590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ICN77_RS11600	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ICN77_RS11605	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ICN77_RS11610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ICN77_RS11695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ICN77_RS11700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ICN77_RS11705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ICN77_RS11710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ICN77_RS11715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ICN77_RS11720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ICN77_RS11725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ICN77_RS11730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ICN77_RS11735	COG0037	tRNA processing
ICN77_RS11740	COG1098	S1 RNA binding domain
ICN77_RS11750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ICN77_RS11755	COG3956	TIGRFAM MazG family protein
ICN77_RS11760	COG2244	polysaccharide biosynthetic process
ICN77_RS11765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ICN77_RS11770	COG0193	aminoacyl-tRNA hydrolase activity
ICN77_RS11775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ICN77_RS11780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ICN77_RS11785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ICN77_RS11790	COG2088	sporulation resulting in formation of a cellular spore
ICN77_RS11795	COG0251	oxidation-reduction process
ICN77_RS11800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ICN77_RS11805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ICN77_RS11810	COG4466	Protein conserved in bacteria
ICN77_RS11815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ICN77_RS11820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ICN77_RS11825	COG0084	hydrolase, TatD family'
ICN77_RS11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICN77_RS11830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICN77_RS11835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ICN77_RS11840	COG2827	Endonuclease containing a URI domain
ICN77_RS11845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ICN77_RS11850	COG4467	Involved in initiation control of chromosome replication
ICN77_RS11855	COG1774	PSP1 C-terminal conserved region
ICN77_RS11860	COG0470	DNA polymerase III
ICN77_RS11865	COG3870	Protein conserved in bacteria
ICN77_RS11870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ICN77_RS11875	COG1982	Orn Lys Arg decarboxylase major
ICN77_RS11900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ICN77_RS11905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ICN77_RS11910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ICN77_RS11925	COG2855	membrane
ICN77_RS11930	COG0583	DNA-binding transcription factor activity
ICN77_RS11940	COG0493	'glutamate synthase
ICN77_RS11945	COG0067	glutamate synthase
ICN77_RS11945	COG0070	glutamate synthase
ICN77_RS11945	COG0069	glutamate synthase activity
ICN77_RS11950	COG0583	DNA-binding transcription factor activity
ICN77_RS11975	COG0438	transferase activity, transferring glycosyl groups
ICN77_RS11980	COG1388	LysM domain
ICN77_RS11980	COG3942	CHAP domain
ICN77_RS11990	COG2011	ABC-type metal ion transport system permease component
ICN77_RS11995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ICN77_RS12000	COG0626	cystathionine gamma-synthase activity
ICN77_RS12005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ICN77_RS12015	COG0733	neurotransmitter:sodium symporter activity
ICN77_RS12025	COG1647	Serine aminopeptidase, S33
ICN77_RS12040	COG5609	conserved protein (DUF2294)
ICN77_RS12045	COG3002	Belongs to the UPF0753 family
ICN77_RS12050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ICN77_RS12070	COG0523	cobalamin synthesis protein
ICN77_RS12085	COG0655	NAD(P)H dehydrogenase (quinone) activity
ICN77_RS12150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ICN77_RS12150	COG0519	Catalyzes the synthesis of GMP from XMP
ICN77_RS12155	COG0516	GMP reductase activity
ICN77_RS12155	COG0517	IMP dehydrogenase activity
ICN77_RS12160	COG2233	PERMEase
ICN77_RS12165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ICN77_RS12180	COG5183	chlorophyll binding
ICN77_RS12185	COG1823	symporter activity
ICN77_RS12190	COG0778	Nitroreductase
ICN77_RS12200	COG0450	alkyl hydroperoxide reductase
ICN77_RS12205	COG3634	alkyl hydroperoxide reductase activity
ICN77_RS12225	COG1280	lysine exporter protein (LysE YggA)
ICN77_RS12240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ICN77_RS12250	COG0360	Binds together with S18 to 16S ribosomal RNA
ICN77_RS12265	COG0012	GTP binding
ICN77_RS12270	COG4481	Protein conserved in bacteria
ICN77_RS12275	COG0668	transmembrane transport
ICN77_RS12280	COG1475	DNA binding
ICN77_RS12285	COG0626	cystathionine gamma-synthase activity
ICN77_RS12290	COG0626	cystathionine gamma-synthase activity
ICN77_RS12295	COG0646	methionine synthase
ICN77_RS12295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ICN77_RS12300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ICN77_RS12310	COG0183	Belongs to the thiolase family
ICN77_RS12320	COG1476	TRANSCRIPTIONal
ICN77_RS12330	COG4555	ABC transporter
ICN77_RS12375	COG1136	(ABC) transporter
ICN77_RS12380	COG0577	efflux transmembrane transporter activity
ICN77_RS12395	COG0577	efflux transmembrane transporter activity
ICN77_RS12400	COG1136	(ABC) transporter
ICN77_RS12435	COG1475	DNA binding
ICN77_RS12440	COG0357	Ribosomal RNA small subunit methyltransferase G
ICN77_RS12445	COG0445	tRNA wobble uridine modification
ICN77_RS12450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ICN77_RS12455	COG0594	ribonuclease P activity