locus-tag	class	description
AVJ22_RS00010	COG0594	ribonuclease P activity
AVJ22_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVJ22_RS00020	COG0445	tRNA wobble uridine modification
AVJ22_RS00025	COG0357	Ribosomal RNA small subunit methyltransferase G
AVJ22_RS00030	COG1475	DNA binding
AVJ22_RS00035	COG1966	Carbon starvation protein
AVJ22_RS00075	COG0656	L-ascorbic acid biosynthetic process
AVJ22_RS00080	COG0531	amino acid
AVJ22_RS00085	COG3386	PFAM SMP-30 Gluconolaconase
AVJ22_RS00095	COG3940	Belongs to the glycosyl hydrolase 43 family
AVJ22_RS00100	COG2223	nitrite transmembrane transporter activity
AVJ22_RS00110	COG0561	phosphatase activity
AVJ22_RS00135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVJ22_RS00160	COG0577	efflux transmembrane transporter activity
AVJ22_RS00180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
AVJ22_RS00210	COG0183	Belongs to the thiolase family
AVJ22_RS00220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVJ22_RS00240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AVJ22_RS00245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AVJ22_RS00245	COG0646	methionine synthase
AVJ22_RS00250	COG0626	cystathionine gamma-synthase activity
AVJ22_RS00255	COG0626	cystathionine gamma-synthase activity
AVJ22_RS00260	COG1475	DNA binding
AVJ22_RS00265	COG1228	amidohydrolase
AVJ22_RS00270	COG1017	nitric oxide dioxygenase activity
AVJ22_RS00270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVJ22_RS00275	COG0175	sulfate reduction
AVJ22_RS00280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVJ22_RS00285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVJ22_RS00305	COG0730	response to heat
AVJ22_RS00310	COG2046	Belongs to the sulfate adenylyltransferase family
AVJ22_RS00315	COG0529	Catalyzes the synthesis of activated sulfate
AVJ22_RS00325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AVJ22_RS00330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVJ22_RS00335	COG0772	Belongs to the SEDS family
AVJ22_RS00360	COG1131	(ABC) transporter
AVJ22_RS00375	COG0753	catalase activity
AVJ22_RS00390	COG1846	Transcriptional regulator
AVJ22_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS00400	COG2030	dehydratase
AVJ22_RS00405	COG1733	regulation of RNA biosynthetic process
AVJ22_RS00415	COG1473	amidohydrolase
AVJ22_RS00420	COG2814	Major facilitator Superfamily
AVJ22_RS00425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVJ22_RS00430	COG1388	LysM domain
AVJ22_RS00440	COG0789	Transcriptional regulator
AVJ22_RS00450	COG2314	TM2 domain
AVJ22_RS00475	COG0300	oxidoreductase activity
AVJ22_RS00490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVJ22_RS00495	COG3002	Belongs to the UPF0753 family
AVJ22_RS00500	COG5609	conserved protein (DUF2294)
AVJ22_RS00505	COG0668	transmembrane transport
AVJ22_RS00510	COG4481	Protein conserved in bacteria
AVJ22_RS00515	COG0012	GTP binding
AVJ22_RS00530	COG0360	Binds together with S18 to 16S ribosomal RNA
AVJ22_RS00540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVJ22_RS00575	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS00580	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVJ22_RS00585	COG1082	Xylose isomerase domain protein TIM barrel
AVJ22_RS00590	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS00595	COG1349	DNA-binding transcription factor activity
AVJ22_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS00605	COG3718	enzyme involved in inositol metabolism
AVJ22_RS00610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVJ22_RS00615	COG3962	Belongs to the TPP enzyme family
AVJ22_RS00620	COG0191	fructose-bisphosphate aldolase activity
AVJ22_RS00625	COG1942	4-Oxalocrotonate Tautomerase
AVJ22_RS00635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AVJ22_RS00640	COG1447	Phosphotransferase system cellobiose-specific component IIA
AVJ22_RS00645	COG2723	6-phospho-beta-galactosidase activity
AVJ22_RS00650	COG3711	transcriptional antiterminator
AVJ22_RS00650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS00655	COG1876	peptidase activity
AVJ22_RS00665	COG4195	phage-related replication protein
AVJ22_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVJ22_RS00690	COG2076	Multidrug Resistance protein
AVJ22_RS00695	COG2076	Multidrug Resistance protein
AVJ22_RS00710	COG0588	phosphoglycerate mutase activity
AVJ22_RS00725	COG3634	alkyl hydroperoxide reductase activity
AVJ22_RS00730	COG0450	alkyl hydroperoxide reductase
AVJ22_RS00745	COG3279	Response regulator of the LytR AlgR family
AVJ22_RS00750	COG3620	sequence-specific DNA binding
AVJ22_RS00755	COG0753	catalase activity
AVJ22_RS00765	COG0778	Nitroreductase
AVJ22_RS00775	COG1823	symporter activity
AVJ22_RS00780	COG5183	chlorophyll binding
AVJ22_RS00795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVJ22_RS00800	COG2233	PERMEase
AVJ22_RS00805	COG0517	IMP dehydrogenase activity
AVJ22_RS00805	COG0516	GMP reductase activity
AVJ22_RS00810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVJ22_RS00810	COG0519	Catalyzes the synthesis of GMP from XMP
AVJ22_RS00860	COG1595	DNA-templated transcription, initiation
AVJ22_RS00870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVJ22_RS00880	COG0406	alpha-ribazole phosphatase activity
AVJ22_RS00885	COG2807	transmembrane transport
AVJ22_RS00905	COG5646	InterPro IPR014922
AVJ22_RS00910	COG1114	Component of the transport system for branched-chain amino acids
AVJ22_RS00915	COG0733	neurotransmitter:sodium symporter activity
AVJ22_RS00920	COG0129	dihydroxy-acid dehydratase activity
AVJ22_RS00930	COG1388	LysM domain
AVJ22_RS00930	COG3942	CHAP domain
AVJ22_RS00945	COG0004	ammonium transporteR
AVJ22_RS00960	COG0583	DNA-binding transcription factor activity
AVJ22_RS00965	COG0069	glutamate synthase activity
AVJ22_RS00965	COG0070	glutamate synthase
AVJ22_RS00965	COG0067	glutamate synthase
AVJ22_RS00970	COG0493	'glutamate synthase
AVJ22_RS00980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS00980	COG1263	PTS System
AVJ22_RS00985	COG0366	Alpha amylase catalytic
AVJ22_RS00990	COG2188	Transcriptional regulator
AVJ22_RS01000	COG3153	acetyltransferase
AVJ22_RS01005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVJ22_RS01010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVJ22_RS01015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVJ22_RS01050	COG1982	Orn Lys Arg decarboxylase major
AVJ22_RS01055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVJ22_RS01060	COG3870	Protein conserved in bacteria
AVJ22_RS01065	COG0470	DNA polymerase III
AVJ22_RS01070	COG1774	PSP1 C-terminal conserved region
AVJ22_RS01075	COG4467	Involved in initiation control of chromosome replication
AVJ22_RS01080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AVJ22_RS01085	COG2827	Endonuclease containing a URI domain
AVJ22_RS01090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVJ22_RS01095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVJ22_RS01095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVJ22_RS01100	COG0084	hydrolase, TatD family'
AVJ22_RS01105	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AVJ22_RS01110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVJ22_RS01115	COG4466	Protein conserved in bacteria
AVJ22_RS01120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVJ22_RS01125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVJ22_RS01130	COG0251	oxidation-reduction process
AVJ22_RS01135	COG2088	sporulation resulting in formation of a cellular spore
AVJ22_RS01140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVJ22_RS01145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVJ22_RS01150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVJ22_RS01155	COG0193	aminoacyl-tRNA hydrolase activity
AVJ22_RS01160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVJ22_RS01165	COG2244	polysaccharide biosynthetic process
AVJ22_RS01170	COG3956	TIGRFAM MazG family protein
AVJ22_RS01175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AVJ22_RS01185	COG1098	S1 RNA binding domain
AVJ22_RS01200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVJ22_RS01205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVJ22_RS01225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AVJ22_RS01230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVJ22_RS01315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVJ22_RS01320	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AVJ22_RS01325	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AVJ22_RS01330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVJ22_RS01335	COG4463	regulation of RNA biosynthetic process
AVJ22_RS01340	COG3880	PFAM UvrB UvrC protein
AVJ22_RS01345	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AVJ22_RS01350	COG0542	response to heat
AVJ22_RS01355	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AVJ22_RS01360	COG4956	integral membrane protein (PIN domain superfamily)
AVJ22_RS01365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVJ22_RS01370	COG1045	serine acetyltransferase
AVJ22_RS01375	COG0215	cysteine-tRNA ligase activity
AVJ22_RS01380	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AVJ22_RS01385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVJ22_RS01390	COG3688	RNA-binding protein containing a PIN domain
AVJ22_RS01405	COG0250	Participates in transcription elongation, termination and antitermination
AVJ22_RS01410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVJ22_RS01415	COG0081	regulation of translation
AVJ22_RS01420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVJ22_RS01425	COG0222	ribosome binding
AVJ22_RS01430	COG2813	Specifically methylates the guanine in position
AVJ22_RS01435	COG0085	RNA polymerase activity
AVJ22_RS01440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVJ22_RS01450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVJ22_RS01455	COG0049	tRNA binding
AVJ22_RS01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVJ22_RS01465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVJ22_RS01470	COG1473	amidohydrolase
AVJ22_RS01500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AVJ22_RS01505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AVJ22_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS01525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AVJ22_RS01550	COG1215	transferase activity, transferring glycosyl groups
AVJ22_RS01550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVJ22_RS01580	COG0583	DNA-binding transcription factor activity
AVJ22_RS01590	COG0800	Aldolase
AVJ22_RS01615	COG1904	glucuronate isomerase
AVJ22_RS01620	COG1312	Catalyzes the dehydration of D-mannonate
AVJ22_RS01625	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS01630	COG1132	(ABC) transporter
AVJ22_RS01635	COG1069	ribulokinase activity
AVJ22_RS01640	COG1914	H( )-stimulated, divalent metal cation uptake system
AVJ22_RS01645	COG0010	Belongs to the arginase family
AVJ22_RS01655	COG0833	amino acid
AVJ22_RS01660	COG2040	homocysteine
AVJ22_RS01665	COG3239	Fatty acid desaturase
AVJ22_RS01685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVJ22_RS01705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVJ22_RS01735	COG1349	DNA-binding transcription factor activity
AVJ22_RS01775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVJ22_RS01785	COG2357	RelA SpoT domain protein
AVJ22_RS01800	COG0546	phosphoglycolate phosphatase activity
AVJ22_RS01810	COG1428	Deoxynucleoside kinase
AVJ22_RS01815	COG1428	Deoxynucleoside kinase
AVJ22_RS01825	COG0561	phosphatase activity
AVJ22_RS01830	COG0431	NADPH-dependent FMN reductase
AVJ22_RS01845	COG1469	GTP cyclohydrolase I activity
AVJ22_RS01850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AVJ22_RS01860	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AVJ22_RS01870	COG3383	formate dehydrogenase (NAD+) activity
AVJ22_RS01880	COG1115	amino acid carrier protein
AVJ22_RS01885	COG0318	PFAM AMP-dependent synthetase and ligase
AVJ22_RS01890	COG0183	Belongs to the thiolase family
AVJ22_RS01920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AVJ22_RS01930	COG2363	Small membrane protein
AVJ22_RS01945	COG2966	Psort location CytoplasmicMembrane, score
AVJ22_RS01950	COG3253	May function as heme-dependent peroxidase
AVJ22_RS01955	COG0280	phosphate acetyltransferase
AVJ22_RS01960	COG0095	Lipoate-protein ligase
AVJ22_RS01965	COG0083	homoserine kinase activity
AVJ22_RS01980	COG1263	PTS System
AVJ22_RS01980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS01985	COG1737	Transcriptional regulator
AVJ22_RS01990	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS02000	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS02005	COG1082	Xylose isomerase domain protein TIM barrel
AVJ22_RS02010	COG4844	belongs to the
AVJ22_RS02015	COG0667	Aldo Keto reductase
AVJ22_RS02020	COG0655	NAD(P)H dehydrogenase (quinone) activity
AVJ22_RS02025	COG0456	acetyltransferase
AVJ22_RS02030	COG1078	dGTPase activity
AVJ22_RS02045	COG0018	arginyl-trna synthetase
AVJ22_RS02050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVJ22_RS02055	COG0789	Transcriptional regulator
AVJ22_RS02060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS02065	COG4139	cobalamin transport
AVJ22_RS02070	COG0546	phosphoglycolate phosphatase activity
AVJ22_RS02075	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVJ22_RS02075	COG0596	Alpha beta hydrolase
AVJ22_RS02090	COG0596	Alpha beta hydrolase
AVJ22_RS02125	COG4974	Belongs to the 'phage' integrase family
AVJ22_RS02130	COG2111	Na H antiporter
AVJ22_RS02130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVJ22_RS02135	COG2111	Na H antiporter
AVJ22_RS02140	COG1006	Multisubunit Na H antiporter MnhC subunit
AVJ22_RS02145	COG0651	ATP synthesis coupled electron transport
AVJ22_RS02150	COG1863	multisubunit Na H antiporter MnhE subunit
AVJ22_RS02155	COG2212	antiporter activity
AVJ22_RS02160	COG1320	monovalent cation:proton antiporter activity
AVJ22_RS02170	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVJ22_RS02175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVJ22_RS02180	COG1121	(ABC) transporter
AVJ22_RS02195	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AVJ22_RS02200	COG1134	teichoic acid transport
AVJ22_RS02205	COG1682	transport, permease protein
AVJ22_RS02210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVJ22_RS02220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AVJ22_RS02230	COG1132	(ABC) transporter
AVJ22_RS02235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVJ22_RS02240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AVJ22_RS02245	COG1120	ATPase activity
AVJ22_RS02250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS02255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS02260	COG2376	Dihydroxyacetone kinase
AVJ22_RS02265	COG1461	Dihydroxyacetone kinase
AVJ22_RS02270	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AVJ22_RS02280	COG3949	Membrane
AVJ22_RS02295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVJ22_RS02300	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS02305	COG2205	protein histidine kinase activity
AVJ22_RS02310	COG1392	Phosphate transport regulator
AVJ22_RS02315	COG0306	phosphate transporter
AVJ22_RS02320	COG1388	LysM domain
AVJ22_RS02320	COG3942	CHAP domain
AVJ22_RS02335	COG0217	transcriptional regulatory protein
AVJ22_RS02345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AVJ22_RS02355	COG0583	DNA-binding transcription factor activity
AVJ22_RS02365	COG2839	Protein conserved in bacteria
AVJ22_RS02370	COG2814	Major facilitator Superfamily
AVJ22_RS02400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVJ22_RS02405	COG1279	arginine transmembrane transporter activity
AVJ22_RS02410	COG1611	Belongs to the LOG family
AVJ22_RS02415	COG1671	Belongs to the UPF0178 family
AVJ22_RS02425	COG1968	undecaprenyl-diphosphatase activity
AVJ22_RS02430	COG4988	ABC transporter
AVJ22_RS02435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AVJ22_RS02450	COG4989	oxidoreductase activity
AVJ22_RS02460	COG0586	Pfam SNARE associated Golgi protein
AVJ22_RS02465	COG0039	L-malate dehydrogenase activity
AVJ22_RS02490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVJ22_RS02495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVJ22_RS02500	COG1349	DNA-binding transcription factor activity
AVJ22_RS02505	COG1105	Belongs to the carbohydrate kinase PfkB family
AVJ22_RS02510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVJ22_RS02510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS02510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVJ22_RS02515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AVJ22_RS02520	COG1253	flavin adenine dinucleotide binding
AVJ22_RS02525	COG0656	L-ascorbic acid biosynthetic process
AVJ22_RS02530	COG0463	Glycosyl transferase, family 2
AVJ22_RS02545	COG0602	queuosine metabolic process
AVJ22_RS02550	COG0720	synthase
AVJ22_RS02555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVJ22_RS02560	COG0512	Glutamine amidotransferase of anthranilate synthase
AVJ22_RS02565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVJ22_RS02580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVJ22_RS02590	COG1368	sulfuric ester hydrolase activity
AVJ22_RS02605	COG0488	(ABC) transporter
AVJ22_RS02610	COG0514	ATP-dependent DNA helicase (RecQ)
AVJ22_RS02620	COG1174	glycine betaine transport
AVJ22_RS02625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVJ22_RS02635	COG1597	lipid kinase activity
AVJ22_RS02640	COG3104	oligopeptide transport
AVJ22_RS02645	COG3104	oligopeptide transport
AVJ22_RS02650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVJ22_RS02660	COG1780	Probably involved in ribonucleotide reductase function
AVJ22_RS02665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVJ22_RS02670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AVJ22_RS02675	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS02680	COG4605	iron ion homeostasis
AVJ22_RS02685	COG4604	ABC transporter, ATP-binding protein
AVJ22_RS02690	COG4607	ABC-type enterochelin transport system periplasmic component
AVJ22_RS02705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVJ22_RS02725	COG1929	Belongs to the glycerate kinase type-1 family
AVJ22_RS02730	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVJ22_RS02745	COG2199	diguanylate cyclase activity
AVJ22_RS02750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVJ22_RS02755	COG1739	Uncharacterized protein family UPF0029
AVJ22_RS02765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AVJ22_RS02770	COG1040	competence protein
AVJ22_RS02775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AVJ22_RS02780	COG0653	protein targeting
AVJ22_RS02785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVJ22_RS02790	COG3942	CHAP domain
AVJ22_RS02790	COG1388	LysM domain
AVJ22_RS02805	COG0556	nucleotide-excision repair
AVJ22_RS02810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVJ22_RS02815	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AVJ22_RS02820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVJ22_RS02825	COG0110	maltose O-acetyltransferase activity
AVJ22_RS02840	COG1660	Displays ATPase and GTPase activities
AVJ22_RS02845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVJ22_RS02850	COG1481	regulation of sporulation
AVJ22_RS02865	COG0740	serine-type endopeptidase activity
AVJ22_RS02870	COG1090	epimerase
AVJ22_RS02905	COG0126	phosphoglycerate kinase activity
AVJ22_RS02910	COG0149	triose-phosphate isomerase activity
AVJ22_RS02915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVJ22_RS02920	COG0148	phosphopyruvate hydratase activity
AVJ22_RS02930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVJ22_RS02935	COG1647	Serine aminopeptidase, S33
AVJ22_RS02940	COG0557	exoribonuclease II activity
AVJ22_RS02945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVJ22_RS03025	COG1278	Cold shock
AVJ22_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS03075	COG0346	lactoylglutathione lyase activity
AVJ22_RS03115	COG2314	TM2 domain
AVJ22_RS03145	COG1764	response to oxidative stress
AVJ22_RS03150	COG0710	3-dehydroquinate dehydratase activity
AVJ22_RS03155	COG0778	Nitroreductase
AVJ22_RS03160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVJ22_RS03165	COG1393	Belongs to the ArsC family
AVJ22_RS03170	COG0509	glycine decarboxylation via glycine cleavage system
AVJ22_RS03175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AVJ22_RS03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVJ22_RS03185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AVJ22_RS03190	COG2011	ABC-type metal ion transport system permease component
AVJ22_RS03195	COG1464	Belongs to the NlpA lipoprotein family
AVJ22_RS03205	COG1253	flavin adenine dinucleotide binding
AVJ22_RS03215	COG0396	ATPase activity
AVJ22_RS03220	COG0719	Fe-S assembly protein
AVJ22_RS03225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVJ22_RS03230	COG0822	iron-sulfur transferase activity
AVJ22_RS03235	COG0719	Fe-S assembly protein
AVJ22_RS03240	COG4536	flavin adenine dinucleotide binding
AVJ22_RS03245	COG2070	2-Nitropropane dioxygenase
AVJ22_RS03250	COG1801	Protein of unknown function DUF72
AVJ22_RS03255	COG0730	response to heat
AVJ22_RS03260	COG0737	Belongs to the 5'-nucleotidase family
AVJ22_RS03265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVJ22_RS03270	COG4470	Protein conserved in bacteria
AVJ22_RS03280	COG2445	Protein of unknown function DUF86
AVJ22_RS03285	COG0647	UMP catabolic process
AVJ22_RS03305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVJ22_RS03310	COG1696	Membrane protein involved in D-alanine export
AVJ22_RS03315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVJ22_RS03320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AVJ22_RS03325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVJ22_RS03330	COG4837	Protein of unknown function (DUF1462)
AVJ22_RS03335	COG1252	NADH dehydrogenase
AVJ22_RS03340	COG4844	belongs to the
AVJ22_RS03345	COG0316	Belongs to the HesB IscA family
AVJ22_RS03350	COG1252	NADH dehydrogenase
AVJ22_RS03355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVJ22_RS03360	COG2056	Na+-H+ antiporter family
AVJ22_RS03365	COG2050	protein possibly involved in aromatic compounds catabolism
AVJ22_RS03375	COG1320	monovalent cation:proton antiporter activity
AVJ22_RS03380	COG2212	antiporter activity
AVJ22_RS03385	COG1863	multisubunit Na H antiporter MnhE subunit
AVJ22_RS03390	COG0651	ATP synthesis coupled electron transport
AVJ22_RS03395	COG1006	Multisubunit Na H antiporter MnhC subunit
AVJ22_RS03400	COG2111	Na H antiporter
AVJ22_RS03405	COG2111	Na H antiporter
AVJ22_RS03405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVJ22_RS03415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVJ22_RS03420	COG1098	S1 RNA binding domain
AVJ22_RS03425	COG1902	pentaerythritol trinitrate reductase activity
AVJ22_RS03430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVJ22_RS03440	COG2832	Protein of unknown function (DUF454)
AVJ22_RS03445	COG0584	glycerophosphoryl diester phosphodiesterase
AVJ22_RS03450	COG0165	Argininosuccinate lyase
AVJ22_RS03455	COG0137	argininosuccinate synthase activity
AVJ22_RS03460	COG0166	Belongs to the GPI family
AVJ22_RS03465	COG0398	Pfam SNARE associated Golgi protein
AVJ22_RS03480	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AVJ22_RS03485	COG1074	ATP-dependent DNA helicase activity
AVJ22_RS03495	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVJ22_RS03510	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVJ22_RS03515	COG0561	phosphatase activity
AVJ22_RS03535	COG0542	response to heat
AVJ22_RS03545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVJ22_RS03565	COG0601	transmembrane transport
AVJ22_RS03570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVJ22_RS03575	COG0444	Belongs to the ABC transporter superfamily
AVJ22_RS03580	COG4608	Belongs to the ABC transporter superfamily
AVJ22_RS03585	COG4166	transmembrane transport
AVJ22_RS03590	COG0180	Tryptophanyl-tRNA synthetase
AVJ22_RS03595	COG1393	Belongs to the ArsC family
AVJ22_RS03600	COG4862	establishment of competence for transformation
AVJ22_RS03610	COG1164	Oligoendopeptidase f
AVJ22_RS03615	COG2910	NAD(P)H-binding
AVJ22_RS03620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AVJ22_RS03625	COG2346	COG2346, Truncated hemoglobins
AVJ22_RS03630	COG4116	CYTH
AVJ22_RS03640	COG2357	RelA SpoT domain protein
AVJ22_RS03645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVJ22_RS03650	COG0564	pseudouridine synthase activity
AVJ22_RS03655	COG2239	Acts as a magnesium transporter
AVJ22_RS03660	COG0475	glutathione-regulated potassium exporter activity
AVJ22_RS03660	COG0569	domain protein
AVJ22_RS03670	COG0628	permease
AVJ22_RS03675	COG1115	amino acid carrier protein
AVJ22_RS03680	COG2382	esterase
AVJ22_RS03685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AVJ22_RS03690	COG2814	Major facilitator Superfamily
AVJ22_RS03695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVJ22_RS03700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVJ22_RS03710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVJ22_RS03715	COG0861	Integral membrane protein TerC family
AVJ22_RS03720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVJ22_RS03725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVJ22_RS03730	COG0737	Belongs to the 5'-nucleotidase family
AVJ22_RS03740	COG4873	Protein conserved in bacteria
AVJ22_RS03755	COG4903	ComK protein
AVJ22_RS03775	COG0659	secondary active sulfate transmembrane transporter activity
AVJ22_RS03780	COG0589	response to stress
AVJ22_RS03795	COG0640	Transcriptional regulator
AVJ22_RS03805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVJ22_RS03810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVJ22_RS03820	COG2314	TM2 domain
AVJ22_RS03830	COG1575	Belongs to the MenA family. Type 1 subfamily
AVJ22_RS03835	COG1169	isochorismate synthase
AVJ22_RS03840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AVJ22_RS03850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AVJ22_RS03860	COG0436	Aminotransferase
AVJ22_RS03865	COG3594	Acyltransferase
AVJ22_RS03890	COG1316	TRANSCRIPTIONal
AVJ22_RS03895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVJ22_RS03900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVJ22_RS03915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AVJ22_RS03920	COG1845	cytochrome c oxidase, subunit III
AVJ22_RS03925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVJ22_RS03930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVJ22_RS03945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVJ22_RS03950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVJ22_RS03955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVJ22_RS03960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVJ22_RS03965	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVJ22_RS03970	COG0047	phosphoribosylformylglycinamidine synthase activity
AVJ22_RS03975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVJ22_RS03985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVJ22_RS03990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVJ22_RS03995	COG0138	bifunctional purine biosynthesis protein purh
AVJ22_RS04000	COG0151	Belongs to the GarS family
AVJ22_RS04010	COG4172	Belongs to the ABC transporter superfamily
AVJ22_RS04025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AVJ22_RS04035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS04040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVJ22_RS04050	COG1271	oxidase subunit
AVJ22_RS04055	COG1294	oxidase, subunit
AVJ22_RS04060	COG0569	domain protein
AVJ22_RS04065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AVJ22_RS04070	COG5503	Protein of unknown function (DUF1447)
AVJ22_RS04080	COG0242	peptide deformylase activity
AVJ22_RS04100	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVJ22_RS04110	COG4476	Belongs to the UPF0223 family
AVJ22_RS04115	COG3842	ATPase activity
AVJ22_RS04120	COG1176	ABC-type spermidine putrescine transport system, permease component I
AVJ22_RS04125	COG1177	transmembrane transport
AVJ22_RS04145	COG4493	Belongs to the UPF0637 family
AVJ22_RS04150	COG0483	inositol monophosphate 1-phosphatase activity
AVJ22_RS04160	COG1217	gtp-binding protein TYPA
AVJ22_RS04165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVJ22_RS04170	COG4838	Belongs to the UPF0358 family
AVJ22_RS04175	COG0772	Belongs to the SEDS family
AVJ22_RS04185	COG1612	heme a metabolic process
AVJ22_RS04190	COG0109	protoheme IX farnesyltransferase activity
AVJ22_RS04210	COG3679	Belongs to the UPF0342 family
AVJ22_RS04220	COG4471	UPF0298 protein
AVJ22_RS04230	COG0742	ribosomal rna small subunit methyltransferase
AVJ22_RS04235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVJ22_RS04240	COG1323	Belongs to the UPF0348 family
AVJ22_RS04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVJ22_RS04260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVJ22_RS04265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVJ22_RS04270	COG0072	phenylalanine-tRNA ligase activity
AVJ22_RS04275	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVJ22_RS04280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AVJ22_RS04290	COG1796	DNA polymerase
AVJ22_RS04290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AVJ22_RS04295	COG1193	negative regulation of DNA recombination
AVJ22_RS04300	COG3118	belongs to the thioredoxin family
AVJ22_RS04305	COG0322	excinuclease ABC activity
AVJ22_RS04310	COG2009	succinate dehydrogenase
AVJ22_RS04315	COG1053	succinate dehydrogenase
AVJ22_RS04320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVJ22_RS04325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVJ22_RS04360	COG0789	Transcriptional regulator
AVJ22_RS04365	COG4221	oxidoreductase activity
AVJ22_RS04375	COG1942	4-Oxalocrotonate Tautomerase
AVJ22_RS04410	COG0584	glycerophosphoryl diester phosphodiesterase
AVJ22_RS04440	COG1011	Hydrolase
AVJ22_RS04445	COG0454	-acetyltransferase
AVJ22_RS04450	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AVJ22_RS04455	COG2001	Belongs to the MraZ family
AVJ22_RS04460	COG0275	rRNA processing
AVJ22_RS04465	COG4839	cell division protein FtsL
AVJ22_RS04470	COG0768	penicillin binding
AVJ22_RS04475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVJ22_RS04480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVJ22_RS04485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AVJ22_RS04490	COG0849	cell division
AVJ22_RS04495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVJ22_RS04500	COG1496	oxidoreductase activity
AVJ22_RS04505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVJ22_RS04510	COG1799	cell septum assembly
AVJ22_RS04515	COG0762	integral membrane protein
AVJ22_RS04520	COG2302	S4 RNA-binding domain
AVJ22_RS04525	COG3599	regulation of cell shape
AVJ22_RS04530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVJ22_RS04545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVJ22_RS04550	COG0564	pseudouridine synthase activity
AVJ22_RS04555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AVJ22_RS04560	COG2233	PERMEase
AVJ22_RS04565	COG0540	Belongs to the ATCase OTCase family
AVJ22_RS04575	COG0505	Belongs to the CarA family
AVJ22_RS04580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVJ22_RS04585	COG0284	orotidine-5'-phosphate decarboxylase activity
AVJ22_RS04590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVJ22_RS04600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AVJ22_RS04610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AVJ22_RS04615	COG0194	GDP metabolic process
AVJ22_RS04620	COG1758	RNA polymerase activity
AVJ22_RS04625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVJ22_RS04630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVJ22_RS04650	COG0242	peptide deformylase activity
AVJ22_RS04655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVJ22_RS04660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVJ22_RS04660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVJ22_RS04665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVJ22_RS04670	COG0631	protein serine/threonine phosphatase activity
AVJ22_RS04685	COG1162	GTPase activity
AVJ22_RS04690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVJ22_RS04695	COG1564	THIamine pyrophosphokinase
AVJ22_RS04700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVJ22_RS04705	COG1302	Protein conserved in bacteria
AVJ22_RS04710	COG1461	Dihydroxyacetone kinase
AVJ22_RS04715	COG1760	l-serine dehydratase
AVJ22_RS04720	COG1760	l-serine dehydratase
AVJ22_RS04725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVJ22_RS04735	COG1349	DNA-binding transcription factor activity
AVJ22_RS04740	COG0416	fatty acid biosynthetic process
AVJ22_RS04755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVJ22_RS04760	COG0571	ribonuclease III activity
AVJ22_RS04765	COG1196	nuclear chromosome segregation
AVJ22_RS04770	COG0552	protein localization to endoplasmic reticulum
AVJ22_RS04775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AVJ22_RS04780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVJ22_RS04785	COG2801	Transposase and inactivated derivatives
AVJ22_RS04795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS04805	COG0228	four-way junction DNA binding
AVJ22_RS04810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVJ22_RS04815	COG0336	Belongs to the RNA methyltransferase TrmD family
AVJ22_RS04820	COG0335	large ribosomal subunit rRNA binding
AVJ22_RS04830	COG4485	Bacterial membrane protein, YfhO
AVJ22_RS04840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVJ22_RS04845	COG0045	succinate-CoA ligase (ADP-forming) activity
AVJ22_RS04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVJ22_RS04865	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AVJ22_RS04870	COG4974	Belongs to the 'phage' integrase family
AVJ22_RS04875	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AVJ22_RS04880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AVJ22_RS04885	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AVJ22_RS04890	COG0052	Belongs to the universal ribosomal protein uS2 family
AVJ22_RS04895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVJ22_RS04900	COG0528	UMP kinase activity
AVJ22_RS04905	COG0233	cytoplasmic translational termination
AVJ22_RS04910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVJ22_RS04915	COG4589	Belongs to the CDS family
AVJ22_RS04925	COG0442	prolyl-tRNA aminoacylation
AVJ22_RS04930	COG2176	DNA-directed DNA polymerase activity
AVJ22_RS04935	COG0779	Required for maturation of 30S ribosomal subunits
AVJ22_RS04940	COG0195	Participates in both transcription termination and antitermination
AVJ22_RS04945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AVJ22_RS04950	COG1358	cellular component organization or biogenesis
AVJ22_RS04955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVJ22_RS04970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVJ22_RS04975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVJ22_RS04980	COG0196	riboflavin kinase activity
AVJ22_RS04985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVJ22_RS04990	COG1185	polyribonucleotide nucleotidyltransferase activity
AVJ22_RS04995	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AVJ22_RS05000	COG1674	ftsk spoiiie
AVJ22_RS05005	COG2188	Transcriptional regulator
AVJ22_RS05010	COG0612	Peptidase, M16
AVJ22_RS05015	COG0612	Peptidase, M16
AVJ22_RS05020	COG0300	oxidoreductase activity
AVJ22_RS05040	COG1058	Belongs to the CinA family
AVJ22_RS05040	COG1546	Belongs to the CinA family
AVJ22_RS05045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVJ22_RS05050	COG1418	mRNA catabolic process
AVJ22_RS05060	COG1692	metallophosphoesterase
AVJ22_RS05065	COG0674	pyruvate-flavodoxin oxidoreductase activity
AVJ22_RS05065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVJ22_RS05070	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVJ22_RS05080	COG1959	2 iron, 2 sulfur cluster binding
AVJ22_RS05085	COG0492	ferredoxin-NADP+ reductase activity
AVJ22_RS05095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVJ22_RS05100	COG4550	Control of competence regulator ComK, YlbF/YmcA
AVJ22_RS05110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVJ22_RS05115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVJ22_RS05125	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVJ22_RS05130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AVJ22_RS05135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVJ22_RS05140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AVJ22_RS05160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVJ22_RS05165	COG1923	regulation of RNA biosynthetic process
AVJ22_RS05170	COG0386	Belongs to the glutathione peroxidase family
AVJ22_RS05175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVJ22_RS05180	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AVJ22_RS05185	COG0789	Transcriptional regulator
AVJ22_RS05190	COG0174	glutamine synthetase
AVJ22_RS05235	COG0527	aspartate kinase activity
AVJ22_RS05240	COG0460	homoserine dehydrogenase
AVJ22_RS05245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AVJ22_RS05250	COG0083	homoserine kinase activity
AVJ22_RS05265	COG0833	amino acid
AVJ22_RS05270	COG0753	catalase activity
AVJ22_RS05280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVJ22_RS05285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVJ22_RS05290	COG0516	GMP reductase activity
AVJ22_RS05305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVJ22_RS05325	COG3763	UPF0154 protein
AVJ22_RS05330	COG0582	viral genome integration into host DNA
AVJ22_RS05340	COG3620	sequence-specific DNA binding
AVJ22_RS05370	COG5377	YqaJ viral recombinase family
AVJ22_RS05375	COG3723	Recombinational DNA repair protein, rece pathway
AVJ22_RS05395	COG1484	DNA-dependent DNA replication
AVJ22_RS05515	COG3331	DNA recombination
AVJ22_RS05605	COG0739	heme binding
AVJ22_RS05670	COG4846	Membrane protein involved in cytochrome C biogenesis
AVJ22_RS05675	COG0420	3'-5' exonuclease activity
AVJ22_RS05680	COG0419	ATPase involved in DNA repair
AVJ22_RS05685	COG1970	mechanosensitive ion channel activity
AVJ22_RS05690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVJ22_RS05695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AVJ22_RS05705	COG4841	protein insertion into membrane
AVJ22_RS05710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVJ22_RS05720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVJ22_RS05725	COG1115	amino acid carrier protein
AVJ22_RS05730	COG3711	transcriptional antiterminator
AVJ22_RS05740	COG0628	permease
AVJ22_RS05745	COG1611	Belongs to the LOG family
AVJ22_RS05750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVJ22_RS05750	COG0392	lysyltransferase activity
AVJ22_RS05765	COG1609	Transcriptional regulator
AVJ22_RS05775	COG1129	ABC transporter
AVJ22_RS05780	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVJ22_RS05785	COG1879	ABC-type sugar transport system periplasmic component
AVJ22_RS05800	COG1942	4-Oxalocrotonate Tautomerase
AVJ22_RS05805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVJ22_RS05810	COG0287	Prephenate dehydrogenase
AVJ22_RS05840	COG1132	(ABC) transporter
AVJ22_RS05855	COG1363	Peptidase, m42
AVJ22_RS05865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVJ22_RS05870	COG0512	Glutamine amidotransferase of anthranilate synthase
AVJ22_RS05875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVJ22_RS05880	COG0134	indole-3-glycerol-phosphate synthase activity
AVJ22_RS05890	COG0133	tryptophan synthase activity
AVJ22_RS05895	COG0159	tryptophan synthase activity
AVJ22_RS05905	COG2348	transferase activity, transferring amino-acyl groups
AVJ22_RS05925	COG1164	Oligoendopeptidase f
AVJ22_RS05935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVJ22_RS05940	COG0581	inorganic phosphate transmembrane transporter activity
AVJ22_RS05945	COG0573	inorganic phosphate transmembrane transporter activity
AVJ22_RS05950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVJ22_RS05955	COG2996	Protein conserved in bacteria
AVJ22_RS05960	COG0488	(ABC) transporter
AVJ22_RS05970	COG0527	aspartate kinase activity
AVJ22_RS05975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AVJ22_RS05980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVJ22_RS05985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVJ22_RS05995	COG1473	amidohydrolase
AVJ22_RS06010	COG1278	Cold shock
AVJ22_RS06020	COG1254	Belongs to the acylphosphatase family
AVJ22_RS06030	COG3853	Toxic anion resistance protein (TelA)
AVJ22_RS06035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVJ22_RS06040	COG1114	Component of the transport system for branched-chain amino acids
AVJ22_RS06045	COG4548	von Willebrand factor, type A
AVJ22_RS06050	COG0714	Associated with various cellular activities
AVJ22_RS06090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVJ22_RS06095	COG0567	Dehydrogenase, E1 component
AVJ22_RS06100	COG5002	protein histidine kinase activity
AVJ22_RS06105	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS06110	COG0671	phosphoesterase, PA-phosphatase related
AVJ22_RS06115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVJ22_RS06125	COG0793	Belongs to the peptidase S41A family
AVJ22_RS06130	COG4479	Belongs to the UPF0346 family
AVJ22_RS06140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVJ22_RS06160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AVJ22_RS06170	COG1413	lyase activity
AVJ22_RS06175	COG1413	lyase activity
AVJ22_RS06185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AVJ22_RS06200	COG0328	RNA-DNA hybrid ribonuclease activity
AVJ22_RS06205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVJ22_RS06210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AVJ22_RS06220	COG2962	Rard protein
AVJ22_RS06225	COG0116	Belongs to the methyltransferase superfamily
AVJ22_RS06240	COG4474	Belongs to the UPF0398 family
AVJ22_RS06250	COG3331	DNA recombination
AVJ22_RS06255	COG4499	WXG100 protein secretion system (Wss), protein YukC
AVJ22_RS06255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVJ22_RS06265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVJ22_RS06270	COG3935	DnaD domain protein
AVJ22_RS06275	COG0017	Asparaginyl-tRNA synthetase
AVJ22_RS06280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AVJ22_RS06280	COG1199	ATP-dependent helicase activity
AVJ22_RS06290	COG0617	tRNA 3'-terminal CCA addition
AVJ22_RS06295	COG0438	transferase activity, transferring glycosyl groups
AVJ22_RS06300	COG1694	Mazg nucleotide pyrophosphohydrolase
AVJ22_RS06310	COG2738	Putative neutral zinc metallopeptidase
AVJ22_RS06315	COG4347	Protein of unknown function (DUF1405)
AVJ22_RS06320	COG5582	Belongs to the UPF0302 family
AVJ22_RS06330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVJ22_RS06335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVJ22_RS06340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVJ22_RS06345	COG0105	UTP biosynthetic process
AVJ22_RS06350	COG0142	geranyltranstransferase activity
AVJ22_RS06355	COG2226	methyltransferase
AVJ22_RS06370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVJ22_RS06375	COG1160	GTP binding
AVJ22_RS06380	COG0539	negative regulation of cytoplasmic translation
AVJ22_RS06385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVJ22_RS06395	COG0492	ferredoxin-NADP+ reductase activity
AVJ22_RS06400	COG1388	LysM domain
AVJ22_RS06405	COG0514	ATP-dependent DNA helicase (RecQ)
AVJ22_RS06415	COG1141	Ferredoxin
AVJ22_RS06430	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS06435	COG1187	pseudouridine synthase activity
AVJ22_RS06440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AVJ22_RS06445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AVJ22_RS06455	COG4974	Belongs to the 'phage' integrase family
AVJ22_RS06460	COG0735	belongs to the Fur family
AVJ22_RS06465	COG0494	nUDIX hydrolase
AVJ22_RS06470	COG0667	Aldo Keto reductase
AVJ22_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVJ22_RS06485	COG1234	tRNA 3'-trailer cleavage
AVJ22_RS06490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVJ22_RS06500	COG0366	Alpha amylase catalytic
AVJ22_RS06505	COG1609	Transcriptional regulator
AVJ22_RS06515	COG2195	Cleaves the N-terminal amino acid of tripeptides
AVJ22_RS06520	COG4129	membrane
AVJ22_RS06530	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVJ22_RS06535	COG0022	dehydrogenase e1 component
AVJ22_RS06540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVJ22_RS06545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVJ22_RS06555	COG0280	phosphate acetyltransferase
AVJ22_RS06560	COG0497	DNA recombination
AVJ22_RS06565	COG1438	arginine binding
AVJ22_RS06575	COG1722	exodeoxyribonuclease VII activity
AVJ22_RS06580	COG1570	exodeoxyribonuclease VII activity
AVJ22_RS06585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVJ22_RS06590	COG1302	Protein conserved in bacteria
AVJ22_RS06595	COG0439	Biotin carboxylase
AVJ22_RS06600	COG0511	ligase activity, forming carbon-carbon bonds
AVJ22_RS06605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVJ22_RS06610	COG0006	proline dipeptidase activity
AVJ22_RS06625	COG0095	Lipoate-protein ligase
AVJ22_RS06630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVJ22_RS06635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVJ22_RS06640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVJ22_RS06645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVJ22_RS06650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVJ22_RS06675	COG4537	Required for transformation and DNA binding
AVJ22_RS06685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVJ22_RS06690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVJ22_RS06695	COG0011	TIGRFAM Protein of
AVJ22_RS06700	COG1940	carbohydrate kinase activity
AVJ22_RS06705	COG4483	Protein conserved in bacteria
AVJ22_RS06715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVJ22_RS06720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVJ22_RS06725	COG0768	penicillin binding
AVJ22_RS06730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVJ22_RS06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVJ22_RS06745	COG1121	(ABC) transporter
AVJ22_RS06750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AVJ22_RS06755	COG0513	Belongs to the DEAD box helicase family
AVJ22_RS06760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVJ22_RS06765	COG2384	SAM-dependent methyltransferase
AVJ22_RS06770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVJ22_RS06780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVJ22_RS06785	COG0517	IMP dehydrogenase activity
AVJ22_RS06790	COG0423	glycine-tRNA ligase activity
AVJ22_RS06795	COG1381	Involved in DNA repair and RecF pathway recombination
AVJ22_RS06800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVJ22_RS06810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AVJ22_RS06815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVJ22_RS06820	COG1702	phosphate starvation-inducible protein PhoH
AVJ22_RS06830	COG4864	UPF0365 protein
AVJ22_RS06840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVJ22_RS06865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVJ22_RS06870	COG2264	protein methyltransferase activity
AVJ22_RS06875	COG0484	heat shock protein binding
AVJ22_RS06880	COG0443	Heat shock 70 kDa protein
AVJ22_RS06885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVJ22_RS06890	COG1420	regulation of RNA biosynthetic process
AVJ22_RS06895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVJ22_RS06900	COG0481	GTPase activity
AVJ22_RS06905	COG0268	Binds directly to 16S ribosomal RNA
AVJ22_RS06910	COG1466	dna polymerase III delta subunit
AVJ22_RS06915	COG2333	competence protein COMEC
AVJ22_RS06915	COG0658	competence protein
AVJ22_RS06920	COG2131	deaminase
AVJ22_RS06925	COG1555	photosystem II stabilization
AVJ22_RS06925	COG1596	polysaccharide export
AVJ22_RS06930	COG2226	methyltransferase
AVJ22_RS06935	COG0799	negative regulation of ribosome biogenesis
AVJ22_RS06940	COG1713	HD superfamily hydrolase involved in NAD metabolism
AVJ22_RS06945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVJ22_RS06950	COG1534	Rna-binding protein
AVJ22_RS06955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVJ22_RS06960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AVJ22_RS06965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AVJ22_RS06970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVJ22_RS06975	COG1914	H( )-stimulated, divalent metal cation uptake system
AVJ22_RS06980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AVJ22_RS06985	COG0439	Biotin carboxylase
AVJ22_RS06995	COG1984	allophanate hydrolase subunit 2
AVJ22_RS07000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AVJ22_RS07005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AVJ22_RS07010	COG0572	uridine kinase
AVJ22_RS07015	COG0826	peptidase U32
AVJ22_RS07020	COG0826	peptidase U32
AVJ22_RS07025	COG4122	O-methyltransferase activity
AVJ22_RS07030	COG3906	Belongs to the UPF0473 family
AVJ22_RS07035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVJ22_RS07040	COG4472	Bacterial protein of unknown function (DUF965)
AVJ22_RS07045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVJ22_RS07050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVJ22_RS07060	COG0482	sulfurtransferase activity
AVJ22_RS07065	COG1104	cysteine desulfurase activity
AVJ22_RS07070	COG0488	(ABC) transporter
AVJ22_RS07075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS07080	COG3237	CsbD-like
AVJ22_RS07085	COG1959	2 iron, 2 sulfur cluster binding
AVJ22_RS07090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVJ22_RS07095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AVJ22_RS07105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVJ22_RS07110	COG0124	histidyl-tRNA synthetase
AVJ22_RS07115	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVJ22_RS07120	COG1490	D-aminoacyl-tRNA deacylase activity
AVJ22_RS07125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVJ22_RS07135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVJ22_RS07135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AVJ22_RS07140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVJ22_RS07140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVJ22_RS07145	COG1862	Preprotein translocase
AVJ22_RS07150	COG0343	queuine tRNA-ribosyltransferase activity
AVJ22_RS07155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVJ22_RS07160	COG2255	four-way junction helicase activity
AVJ22_RS07165	COG0632	four-way junction helicase activity
AVJ22_RS07170	COG4492	Belongs to the UPF0735 family
AVJ22_RS07175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVJ22_RS07180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVJ22_RS07185	COG2868	ribosomal protein
AVJ22_RS07190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVJ22_RS07230	COG2003	Belongs to the UPF0758 family
AVJ22_RS07245	COG0285	dihydrofolate synthase activity
AVJ22_RS07250	COG0525	valine-tRNA ligase activity
AVJ22_RS07255	COG2818	Glycosylase
AVJ22_RS07265	COG3180	Ammonia monooxygenase
AVJ22_RS07270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVJ22_RS07275	COG0113	porphobilinogen synthase activity
AVJ22_RS07280	COG1587	Uroporphyrinogen-III synthase
AVJ22_RS07285	COG0181	hydroxymethylbilane synthase activity
AVJ22_RS07290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVJ22_RS07295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVJ22_RS07300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AVJ22_RS07305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVJ22_RS07310	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVJ22_RS07320	COG4112	unkown
AVJ22_RS07325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVJ22_RS07330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVJ22_RS07335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVJ22_RS07340	COG0833	amino acid
AVJ22_RS07345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVJ22_RS07350	COG1484	DNA-dependent DNA replication
AVJ22_RS07360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AVJ22_RS07365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVJ22_RS07370	COG0237	dephospho-CoA kinase activity
AVJ22_RS07380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVJ22_RS07380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVJ22_RS07385	COG5002	protein histidine kinase activity
AVJ22_RS07390	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS07395	COG0538	isocitrate dehydrogenase activity
AVJ22_RS07400	COG0372	Belongs to the citrate synthase family
AVJ22_RS07405	COG1113	amino acid transport
AVJ22_RS07410	COG0469	pyruvate kinase activity
AVJ22_RS07415	COG0205	6-phosphofructokinase activity
AVJ22_RS07420	COG0825	malonyl-CoA metabolic process
AVJ22_RS07425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVJ22_RS07430	COG0281	malic enzyme
AVJ22_RS07435	COG0587	DNA-directed DNA polymerase activity
AVJ22_RS07440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AVJ22_RS07445	COG4109	DRTGG domain
AVJ22_RS07455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AVJ22_RS07460	COG0006	proline dipeptidase activity
AVJ22_RS07465	COG3142	Participates in the control of copper homeostasis
AVJ22_RS07470	COG0686	Belongs to the AlaDH PNT family
AVJ22_RS07475	COG0589	response to stress
AVJ22_RS07485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVJ22_RS07490	COG0827	DNA restriction-modification system
AVJ22_RS07495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AVJ22_RS07500	COG1714	RDD family
AVJ22_RS07505	COG0616	signal peptide processing
AVJ22_RS07515	COG0301	tRNA thio-modification
AVJ22_RS07520	COG1104	cysteine desulfurase activity
AVJ22_RS07525	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AVJ22_RS07530	COG1956	GAF domain-containing protein
AVJ22_RS07535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVJ22_RS07545	COG0584	glycerophosphoryl diester phosphodiesterase
AVJ22_RS07550	COG1764	response to oxidative stress
AVJ22_RS07555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVJ22_RS07560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVJ22_RS07570	COG1263	PTS System
AVJ22_RS07570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS07575	COG0204	Acyl-transferase
AVJ22_RS07580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVJ22_RS07585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVJ22_RS07600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVJ22_RS07605	COG0454	-acetyltransferase
AVJ22_RS07610	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVJ22_RS07615	COG1609	Transcriptional regulator
AVJ22_RS07620	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AVJ22_RS07620	COG1605	Chorismate mutase
AVJ22_RS07630	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AVJ22_RS07635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVJ22_RS07640	COG1674	ftsk spoiiie
AVJ22_RS07645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVJ22_RS07650	COG4848	Belongs to the UPF0354 family
AVJ22_RS07655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVJ22_RS07660	COG1363	Peptidase, m42
AVJ22_RS07665	COG5584	Small secreted protein
AVJ22_RS07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVJ22_RS07675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVJ22_RS07680	COG0510	thiamine kinase activity
AVJ22_RS07690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AVJ22_RS07700	COG1187	pseudouridine synthase activity
AVJ22_RS07705	COG2244	polysaccharide biosynthetic process
AVJ22_RS07710	COG2081	HI0933 family
AVJ22_RS07730	COG0495	leucyl-tRNA aminoacylation
AVJ22_RS07735	COG2814	Major facilitator Superfamily
AVJ22_RS07740	COG1242	4 iron, 4 sulfur cluster binding
AVJ22_RS07745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AVJ22_RS07755	COG0039	L-malate dehydrogenase activity
AVJ22_RS07760	COG2267	carboxylic ester hydrolase activity
AVJ22_RS07765	COG0506	proline dehydrogenase activity
AVJ22_RS07770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVJ22_RS07775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVJ22_RS07775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVJ22_RS07780	COG0307	riboflavin synthase, alpha
AVJ22_RS07785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVJ22_RS07785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVJ22_RS07800	COG3266	domain, Protein
AVJ22_RS07800	COG4193	domain, Protein
AVJ22_RS07800	COG5632	N-Acetylmuramoyl-L-alanine amidase
AVJ22_RS07830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVJ22_RS07840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVJ22_RS07845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVJ22_RS07850	COG0656	L-ascorbic acid biosynthetic process
AVJ22_RS07860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVJ22_RS07865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AVJ22_RS07870	COG1506	peptidase
AVJ22_RS07880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AVJ22_RS07890	COG0318	PFAM AMP-dependent synthetase and ligase
AVJ22_RS07905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AVJ22_RS07950	COG3545	Serine hydrolase
AVJ22_RS07955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AVJ22_RS07960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVJ22_RS07965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVJ22_RS07975	COG4473	ABC transporter
AVJ22_RS07980	COG1131	(ABC) transporter
AVJ22_RS07985	COG0537	adenosine 5'-monophosphoramidase activity
AVJ22_RS08000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVJ22_RS08005	COG3481	metal-dependent phosphohydrolase, HD sub domain
AVJ22_RS08010	COG4717	serine-type aminopeptidase activity
AVJ22_RS08015	COG0420	3'-5' exonuclease activity
AVJ22_RS08020	COG3679	Belongs to the UPF0342 family
AVJ22_RS08025	COG4399	Belongs to the UPF0754 family
AVJ22_RS08035	COG0788	formyltetrahydrofolate deformylase activity
AVJ22_RS08050	COG1301	dicarboxylic acid transport
AVJ22_RS08055	COG2197	response regulator
AVJ22_RS08060	COG2203	Gaf domain
AVJ22_RS08060	COG4585	Histidine kinase
AVJ22_RS08065	COG0564	pseudouridine synthase activity
AVJ22_RS08080	COG0114	fumarate hydratase activity
AVJ22_RS08100	COG0363	glucosamine-6-phosphate deaminase activity
AVJ22_RS08110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVJ22_RS08115	COG1126	abc transporter atp-binding protein
AVJ22_RS08120	COG0765	amino acid transport
AVJ22_RS08270	COG0735	belongs to the Fur family
AVJ22_RS08275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVJ22_RS08280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVJ22_RS08285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVJ22_RS08290	COG4129	membrane
AVJ22_RS08300	COG3557	Belongs to the UPF0374 family
AVJ22_RS08305	COG1194	a g-specific adenine glycosylase
AVJ22_RS08310	COG1988	membrane-bound metal-dependent
AVJ22_RS08330	COG2137	regulation of response to DNA damage stimulus
AVJ22_RS08335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AVJ22_RS08340	COG0693	protein deglycase activity
AVJ22_RS08345	COG1607	acyl-coa hydrolase
AVJ22_RS08350	COG2309	aminopeptidase activity
AVJ22_RS08355	COG4840	Belongs to the UPF0435 family
AVJ22_RS08360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVJ22_RS08370	COG1295	ribonuclease BN
AVJ22_RS08375	COG2197	response regulator
AVJ22_RS08380	COG4585	Histidine kinase
AVJ22_RS08395	COG0024	Methionine aminopeptidase
AVJ22_RS08400	COG4129	membrane
AVJ22_RS08415	COG1528	Iron-storage protein
AVJ22_RS08430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AVJ22_RS08440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVJ22_RS08445	COG1597	lipid kinase activity
AVJ22_RS08450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVJ22_RS08455	COG0154	amidase activity
AVJ22_RS08460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVJ22_RS08465	COG4851	CamS sex pheromone cAM373 precursor
AVJ22_RS08470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVJ22_RS08475	COG0210	DNA helicase
AVJ22_RS08480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AVJ22_RS08490	COG4496	protein, YerC YecD
AVJ22_RS08495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVJ22_RS08505	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AVJ22_RS08510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AVJ22_RS08515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AVJ22_RS08525	COG0077	Prephenate dehydratase
AVJ22_RS08530	COG0471	metal ion transport
AVJ22_RS08540	COG1335	isochorismatase
AVJ22_RS08545	COG1227	inorganic diphosphatase activity
AVJ22_RS08550	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS08555	COG2706	6-phosphogluconolactonase activity
AVJ22_RS08595	COG1131	(ABC) transporter
AVJ22_RS08610	COG1725	Transcriptional regulator
AVJ22_RS08650	COG0346	lactoylglutathione lyase activity
AVJ22_RS08680	COG0459	protein refolding
AVJ22_RS08685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVJ22_RS08710	COG4512	PFAM Accessory gene regulator B
AVJ22_RS08725	COG3279	Response regulator of the LytR AlgR family
AVJ22_RS08735	COG1621	beta-fructofuranosidase activity
AVJ22_RS08740	COG1609	Transcriptional regulator
AVJ22_RS08745	COG0425	Belongs to the sulfur carrier protein TusA family
AVJ22_RS08750	COG2391	methyltransferase activity
AVJ22_RS08755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AVJ22_RS08760	COG0488	(ABC) transporter
AVJ22_RS08770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVJ22_RS08775	COG0456	acetyltransferase
AVJ22_RS08780	COG1214	PFAM Peptidase M22, glycoprotease
AVJ22_RS08785	COG0802	atpase or kinase
AVJ22_RS08790	COG0129	dihydroxy-acid dehydratase activity
AVJ22_RS08795	COG0028	Belongs to the TPP enzyme family
AVJ22_RS08800	COG0440	acetolactate synthase activity
AVJ22_RS08805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVJ22_RS08810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVJ22_RS08815	COG0473	3-isopropylmalate dehydrogenase activity
AVJ22_RS08820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVJ22_RS08825	COG0066	3-isopropylmalate dehydratase activity
AVJ22_RS08830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVJ22_RS08865	COG3091	SprT-like family
AVJ22_RS08870	COG2183	response to ionizing radiation
AVJ22_RS08875	COG1191	sigma factor activity
AVJ22_RS08890	COG2208	phosphoserine phosphatase activity
AVJ22_RS08895	COG2337	Toxic component of a toxin-antitoxin (TA) module
AVJ22_RS08905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVJ22_RS08910	COG0736	holo-[acyl-carrier-protein] synthase activity
AVJ22_RS08920	COG3428	Bacterial PH domain
AVJ22_RS08930	COG0513	Belongs to the DEAD box helicase family
AVJ22_RS08935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVJ22_RS08940	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVJ22_RS08945	COG0772	Belongs to the SEDS family
AVJ22_RS08960	COG1937	Protein conserved in bacteria
AVJ22_RS08970	COG1418	mRNA catabolic process
AVJ22_RS08975	COG0706	membrane insertase activity
AVJ22_RS08980	COG0352	thiamine-phosphate diphosphorylase activity
AVJ22_RS08985	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AVJ22_RS08995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AVJ22_RS09000	COG1388	LysM domain
AVJ22_RS09005	COG0629	single-stranded DNA binding
AVJ22_RS09015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVJ22_RS09020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVJ22_RS09030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVJ22_RS09035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVJ22_RS09040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVJ22_RS09045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVJ22_RS09050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVJ22_RS09055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVJ22_RS09060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVJ22_RS09065	COG0356	it plays a direct role in the translocation of protons across the membrane
AVJ22_RS09075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AVJ22_RS09080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVJ22_RS09085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVJ22_RS09090	COG4475	Protein of unknown function (DUF436)
AVJ22_RS09095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVJ22_RS09100	COG0009	L-threonylcarbamoyladenylate synthase
AVJ22_RS09105	COG2890	protein-(glutamine-N5) methyltransferase activity
AVJ22_RS09110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVJ22_RS09115	COG1435	thymidine kinase activity
AVJ22_RS09120	COG0254	rRNA binding
AVJ22_RS09125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AVJ22_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS09140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVJ22_RS09145	COG0191	fructose-bisphosphate aldolase activity
AVJ22_RS09150	COG0504	CTP synthase activity
AVJ22_RS09155	COG3343	RNA polymerase activity
AVJ22_RS09160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVJ22_RS09170	COG5146	pantothenate kinase activity
AVJ22_RS09190	COG1854	S-ribosylhomocysteine lyase activity
AVJ22_RS09200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AVJ22_RS09205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AVJ22_RS09210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AVJ22_RS09215	COG0813	purine-nucleoside phosphorylase activity
AVJ22_RS09220	COG0783	Belongs to the Dps family
AVJ22_RS09225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVJ22_RS09240	COG2855	membrane
AVJ22_RS09250	COG1482	cell wall glycoprotein biosynthetic process
AVJ22_RS09255	COG2186	Transcriptional regulator
AVJ22_RS09260	COG0702	epimerase
AVJ22_RS09265	COG0640	Transcriptional regulator
AVJ22_RS09290	COG1119	ATPase activity
AVJ22_RS09315	COG3711	transcriptional antiterminator
AVJ22_RS09325	COG0246	Mannitol dehydrogenase
AVJ22_RS09330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVJ22_RS09340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AVJ22_RS09405	COG0489	protein tyrosine kinase activity
AVJ22_RS09420	COG1272	protein, Hemolysin III
AVJ22_RS09425	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AVJ22_RS09430	COG1988	membrane-bound metal-dependent
AVJ22_RS09440	COG2329	Antibiotic biosynthesis monooxygenase
AVJ22_RS09445	COG3314	Sporulation integral membrane protein YlbJ
AVJ22_RS09450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS09455	COG3457	Alanine racemase
AVJ22_RS09460	COG4264	IucA IucC family
AVJ22_RS09470	COG1302	Protein conserved in bacteria
AVJ22_RS09485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVJ22_RS09490	COG0604	alcohol dehydrogenase
AVJ22_RS09495	COG2130	NADP-dependent
AVJ22_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS09555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVJ22_RS09560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVJ22_RS09565	COG0101	tRNA pseudouridine synthase activity
AVJ22_RS09575	COG1122	ATPase activity
AVJ22_RS09580	COG1122	ATPase activity
AVJ22_RS09585	COG0203	ribosomal protein L17
AVJ22_RS09590	COG0202	RNA polymerase activity
AVJ22_RS09600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVJ22_RS09605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVJ22_RS09620	COG0201	protein transport
AVJ22_RS09630	COG1841	ribosomal large subunit assembly
AVJ22_RS09635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVJ22_RS09640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVJ22_RS09645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVJ22_RS09650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVJ22_RS09655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVJ22_RS09660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVJ22_RS09665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVJ22_RS09670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVJ22_RS09675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVJ22_RS09680	COG0255	Belongs to the universal ribosomal protein uL29 family
AVJ22_RS09685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVJ22_RS09690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVJ22_RS09695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVJ22_RS09700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVJ22_RS09705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVJ22_RS09710	COG0089	rRNA binding
AVJ22_RS09715	COG0088	Forms part of the polypeptide exit tunnel
AVJ22_RS09720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVJ22_RS09725	COG0051	transcription antitermination factor activity, RNA binding
AVJ22_RS09735	COG2252	PERMEase
AVJ22_RS09740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVJ22_RS09740	COG0551	DNA topoisomerase type I activity
AVJ22_RS09750	COG4975	Glucose uptake
AVJ22_RS09770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVJ22_RS09775	COG2348	transferase activity, transferring amino-acyl groups
AVJ22_RS09795	COG2814	Major facilitator Superfamily
AVJ22_RS09805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVJ22_RS09810	COG0746	molybdenum cofactor guanylyltransferase activity
AVJ22_RS09825	COG1763	Mo-molybdopterin cofactor biosynthetic process
AVJ22_RS09835	COG0315	cyclic pyranopterin monophosphate synthase activity
AVJ22_RS09840	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVJ22_RS09845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVJ22_RS09850	COG1510	regulation of RNA biosynthetic process
AVJ22_RS09855	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AVJ22_RS09860	COG4149	molybdate abc transporter
AVJ22_RS09865	COG0725	ABC transporter, periplasmic molybdate-binding protein
AVJ22_RS09870	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AVJ22_RS09875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVJ22_RS09880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AVJ22_RS09885	COG1609	Transcriptional regulator
AVJ22_RS09890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AVJ22_RS09900	COG1268	BioY protein
AVJ22_RS09905	COG2801	Transposase and inactivated derivatives
AVJ22_RS09910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS09915	COG1960	acyl-CoA dehydrogenase activity
AVJ22_RS09920	COG1126	abc transporter atp-binding protein
AVJ22_RS09925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVJ22_RS09930	COG0765	amino acid transport
AVJ22_RS09935	COG0765	amino acid transport
AVJ22_RS09960	COG3942	CHAP domain
AVJ22_RS09975	COG1757	Na H antiporter
AVJ22_RS09995	COG2076	Multidrug Resistance protein
AVJ22_RS10000	COG2076	Multidrug Resistance protein
AVJ22_RS10005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVJ22_RS10015	COG4193	domain, Protein
AVJ22_RS10030	COG3383	formate dehydrogenase (NAD+) activity
AVJ22_RS10035	COG1316	TRANSCRIPTIONal
AVJ22_RS10040	COG0483	inositol monophosphate 1-phosphatase activity
AVJ22_RS10060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AVJ22_RS10065	COG1263	PTS System
AVJ22_RS10065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS10075	COG1785	Belongs to the alkaline phosphatase family
AVJ22_RS10080	COG1113	amino acid transport
AVJ22_RS10105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVJ22_RS10110	COG0385	Bile acid
AVJ22_RS10120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS10120	COG1263	PTS System
AVJ22_RS10140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVJ22_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS10150	COG1473	amidohydrolase
AVJ22_RS10155	COG0659	secondary active sulfate transmembrane transporter activity
AVJ22_RS10160	COG1228	amidohydrolase
AVJ22_RS10165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AVJ22_RS10170	COG3314	Sporulation integral membrane protein YlbJ
AVJ22_RS10175	COG0583	DNA-binding transcription factor activity
AVJ22_RS10180	COG0010	Belongs to the arginase family
AVJ22_RS10185	COG1266	CAAX protease self-immunity
AVJ22_RS10190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVJ22_RS10195	COG2258	MOSC domain
AVJ22_RS10205	COG1668	transmembrane transport
AVJ22_RS10210	COG4152	abc transporter atp-binding protein
AVJ22_RS10220	COG2094	Belongs to the DNA glycosylase MPG family
AVJ22_RS10225	COG1757	Na H antiporter
AVJ22_RS10230	COG0786	glutamate:sodium symporter activity
AVJ22_RS10235	COG1304	FMN binding
AVJ22_RS10240	COG0598	Magnesium transport protein CorA
AVJ22_RS10265	COG2814	Major facilitator Superfamily
AVJ22_RS10270	COG1566	PFAM secretion protein HlyD family protein
AVJ22_RS10280	COG2814	Major facilitator Superfamily
AVJ22_RS10285	COG4640	response to antibiotic
AVJ22_RS10300	COG1136	(ABC) transporter
AVJ22_RS10305	COG0577	efflux transmembrane transporter activity
AVJ22_RS10310	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS10315	COG5002	protein histidine kinase activity
AVJ22_RS10315	COG3850	Histidine kinase
AVJ22_RS10325	COG0438	transferase activity, transferring glycosyl groups
AVJ22_RS10330	COG1620	l-lactate permease
AVJ22_RS10335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVJ22_RS10350	COG0604	alcohol dehydrogenase
AVJ22_RS10355	COG2814	Major facilitator Superfamily
AVJ22_RS10365	COG0492	ferredoxin-NADP+ reductase activity
AVJ22_RS10390	COG0698	ribose 5-phosphate isomerase
AVJ22_RS10400	COG2376	Dihydroxyacetone kinase
AVJ22_RS10405	COG1063	alcohol dehydrogenase
AVJ22_RS10410	COG1349	DNA-binding transcription factor activity
AVJ22_RS10420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS10425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS10430	COG1283	sodium-dependent phosphate transmembrane transporter activity
AVJ22_RS10450	COG1263	PTS System
AVJ22_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS10475	COG1846	Transcriptional regulator
AVJ22_RS10485	COG2223	nitrite transmembrane transporter activity
AVJ22_RS10495	COG4585	Histidine kinase
AVJ22_RS10505	COG2181	nitrate reductase activity
AVJ22_RS10510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AVJ22_RS10515	COG1140	nitrate reductase beta subunit
AVJ22_RS10520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AVJ22_RS10525	COG1648	precorrin-2 dehydrogenase activity
AVJ22_RS10525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVJ22_RS10530	COG2146	nitrite reductase [NAD(P)H] activity
AVJ22_RS10535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVJ22_RS10550	COG0454	-acetyltransferase
AVJ22_RS10555	COG2116	formate transmembrane transporter activity
AVJ22_RS10560	COG1959	2 iron, 2 sulfur cluster binding
AVJ22_RS10585	COG2353	YceI-like domain
AVJ22_RS10590	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVJ22_RS10590	COG3443	Belongs to the bacterial solute-binding protein 9 family
AVJ22_RS10595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVJ22_RS10610	COG2814	Major facilitator Superfamily
AVJ22_RS10625	COG0588	phosphoglycerate mutase activity
AVJ22_RS10630	COG1388	LysM domain
AVJ22_RS10635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AVJ22_RS10645	COG2814	Major facilitator Superfamily
AVJ22_RS10660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVJ22_RS10670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AVJ22_RS10690	COG4187	Peptidase family M20/M25/M40
AVJ22_RS10710	COG1960	acyl-CoA dehydrogenase activity
AVJ22_RS10720	COG1174	glycine betaine transport
AVJ22_RS10730	COG1174	glycine betaine transport
AVJ22_RS10745	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVJ22_RS10750	COG3246	L-lysine catabolic process to acetate
AVJ22_RS10760	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AVJ22_RS10765	COG0531	amino acid
AVJ22_RS10770	COG2814	Major facilitator Superfamily
AVJ22_RS10775	COG0390	transport system, permease component
AVJ22_RS10780	COG4619	ABC transporter
AVJ22_RS10790	COG0069	glutamate synthase activity
AVJ22_RS10800	COG1363	Peptidase, m42
AVJ22_RS10805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AVJ22_RS10815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVJ22_RS10825	COG3048	D-serine ammonia-lyase activity
AVJ22_RS10835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVJ22_RS10840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVJ22_RS10845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVJ22_RS10850	COG0131	Imidazoleglycerol-phosphate dehydratase
AVJ22_RS10855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVJ22_RS10860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVJ22_RS10865	COG0107	imidazoleglycerol-phosphate synthase activity
AVJ22_RS10875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS10895	COG4221	oxidoreductase activity
AVJ22_RS10920	COG3949	Membrane
AVJ22_RS10925	COG2610	gluconate transmembrane transporter activity
AVJ22_RS10935	COG1802	Transcriptional regulator
AVJ22_RS10940	COG2357	RelA SpoT domain protein
AVJ22_RS10945	COG4876	unkown
AVJ22_RS10960	COG1289	transmembrane transporter activity
AVJ22_RS10975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVJ22_RS10980	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AVJ22_RS10990	COG3949	Membrane
AVJ22_RS10995	COG0400	carboxylic ester hydrolase activity
AVJ22_RS11000	COG0346	lactoylglutathione lyase activity
AVJ22_RS11005	COG0346	lactoylglutathione lyase activity
AVJ22_RS11010	COG1846	Transcriptional regulator
AVJ22_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS11020	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVJ22_RS11030	COG1132	(ABC) transporter
AVJ22_RS11035	COG1132	(ABC) transporter
AVJ22_RS11045	COG2514	catechol 2,3-dioxygenase activity
AVJ22_RS11050	COG0778	Nitroreductase
AVJ22_RS11055	COG0561	phosphatase activity
AVJ22_RS11060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVJ22_RS11065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVJ22_RS11075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AVJ22_RS11080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AVJ22_RS11085	COG3764	Sortase (surface protein transpeptidase)
AVJ22_RS11110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVJ22_RS11115	COG1063	alcohol dehydrogenase
AVJ22_RS11120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVJ22_RS11130	COG2843	Capsule synthesis protein
AVJ22_RS11140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVJ22_RS11155	COG0657	acetylesterase activity
AVJ22_RS11170	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AVJ22_RS11185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS11185	COG1263	PTS System
AVJ22_RS11185	COG2190	(PTS) system
AVJ22_RS11195	COG0028	Belongs to the TPP enzyme family
AVJ22_RS11210	COG0583	DNA-binding transcription factor activity
AVJ22_RS11215	COG1757	Na H antiporter
AVJ22_RS11220	COG3386	PFAM SMP-30 Gluconolaconase
AVJ22_RS11235	COG3425	synthase
AVJ22_RS11240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVJ22_RS11245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVJ22_RS11265	COG2409	Drug exporters of the RND superfamily
AVJ22_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS11280	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
AVJ22_RS11295	COG4336	lyase activity
AVJ22_RS11310	COG5505	Protein of unknown function (DUF819)
AVJ22_RS11315	COG0471	metal ion transport
AVJ22_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS11335	COG0577	efflux transmembrane transporter activity
AVJ22_RS11340	COG1136	(ABC) transporter
AVJ22_RS11345	COG0659	secondary active sulfate transmembrane transporter activity
AVJ22_RS11350	COG2217	Heavy metal translocating P-type atpase
AVJ22_RS11355	COG2608	mercury ion transmembrane transporter activity
AVJ22_RS11365	COG0436	Aminotransferase
AVJ22_RS11370	COG0741	lytic transglycosylase activity
AVJ22_RS11385	COG3189	MarR family transcriptional regulator
AVJ22_RS11390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AVJ22_RS11400	COG1957	nucleoside hydrolase
AVJ22_RS11425	COG3001	Fructosamine kinase
AVJ22_RS11430	COG0167	dihydroorotate dehydrogenase activity
AVJ22_RS11440	COG0561	phosphatase activity
AVJ22_RS11455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS11480	COG0747	negative chemotaxis
AVJ22_RS11485	COG4413	Urea transporter
AVJ22_RS11490	COG0831	urea catabolic process
AVJ22_RS11495	COG0832	Belongs to the urease beta subunit family
AVJ22_RS11500	COG0804	urea catabolic process
AVJ22_RS11505	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVJ22_RS11510	COG0830	nickel cation binding
AVJ22_RS11515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVJ22_RS11520	COG0829	nickel cation binding
AVJ22_RS11530	COG3949	Membrane
AVJ22_RS11540	COG0626	cystathionine gamma-synthase activity
AVJ22_RS11545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVJ22_RS11565	COG1940	carbohydrate kinase activity
AVJ22_RS11570	COG1482	cell wall glycoprotein biosynthetic process
AVJ22_RS11575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVJ22_RS11575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AVJ22_RS11575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS11580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS11580	COG3711	transcriptional antiterminator
AVJ22_RS11585	COG0039	L-malate dehydrogenase activity
AVJ22_RS11590	COG1464	Belongs to the NlpA lipoprotein family
AVJ22_RS11595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVJ22_RS11610	COG3181	Tripartite tricarboxylate transporter family receptor
AVJ22_RS11620	COG3037	sugar-specific permease SgaT UlaA
AVJ22_RS11630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AVJ22_RS11640	COG1447	Phosphotransferase system cellobiose-specific component IIA
AVJ22_RS11655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AVJ22_RS11665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVJ22_RS11670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVJ22_RS11680	COG2348	transferase activity, transferring amino-acyl groups
AVJ22_RS11685	COG0363	glucosamine-6-phosphate deaminase activity
AVJ22_RS11690	COG2190	(PTS) system
AVJ22_RS11690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AVJ22_RS11690	COG1263	PTS System
AVJ22_RS11700	COG2814	Major facilitator Superfamily
AVJ22_RS11705	COG1620	l-lactate permease
AVJ22_RS11715	COG0431	NADPH-dependent FMN reductase
AVJ22_RS11725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVJ22_RS11730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVJ22_RS11735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVJ22_RS11740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVJ22_RS11750	COG1131	(ABC) transporter
AVJ22_RS11775	COG1957	nucleoside hydrolase
AVJ22_RS11780	COG2843	Capsule synthesis protein
AVJ22_RS11790	COG0778	Nitroreductase
AVJ22_RS11800	COG0463	Glycosyl transferase, family 2
AVJ22_RS11800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AVJ22_RS11815	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AVJ22_RS11820	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS11825	COG1510	regulation of RNA biosynthetic process
AVJ22_RS11830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AVJ22_RS11835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVJ22_RS11860	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS11865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVJ22_RS11870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVJ22_RS11880	COG2807	transmembrane transport
AVJ22_RS11885	COG1476	TRANSCRIPTIONal
AVJ22_RS11910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AVJ22_RS11915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVJ22_RS11915	COG0574	Belongs to the PEP-utilizing enzyme family
AVJ22_RS11920	COG3835	regulator
AVJ22_RS11925	COG1929	Belongs to the glycerate kinase type-1 family
AVJ22_RS11935	COG3875	lactate racemase activity
AVJ22_RS11940	COG1606	tRNA processing
AVJ22_RS11945	COG1691	(AIR) carboxylase
AVJ22_RS11950	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AVJ22_RS11955	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS11995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS12005	COG3961	Belongs to the TPP enzyme family
AVJ22_RS12015	COG1846	Transcriptional regulator
AVJ22_RS12040	COG0584	glycerophosphoryl diester phosphodiesterase
AVJ22_RS12050	COG2814	Major facilitator Superfamily
AVJ22_RS12060	COG0477	Major facilitator Superfamily
AVJ22_RS12075	COG0579	oxidoreductase
AVJ22_RS12080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVJ22_RS12085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVJ22_RS12090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVJ22_RS12100	COG1115	amino acid carrier protein
AVJ22_RS12125	COG1136	(ABC) transporter
AVJ22_RS12130	COG2610	gluconate transmembrane transporter activity
AVJ22_RS12140	COG2084	Dehydrogenase
AVJ22_RS12145	COG2188	Transcriptional regulator
AVJ22_RS12150	COG0346	lactoylglutathione lyase activity
AVJ22_RS12160	COG0431	NADPH-dependent FMN reductase
AVJ22_RS12165	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AVJ22_RS12170	COG0602	queuosine metabolic process
AVJ22_RS12175	COG1328	CTP reductase activity
AVJ22_RS12180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVJ22_RS12185	COG2022	thiamine diphosphate biosynthetic process
AVJ22_RS12205	COG1070	Carbohydrate kinase
AVJ22_RS12235	COG1511	domain protein
AVJ22_RS12250	COG1131	(ABC) transporter
AVJ22_RS12260	COG1940	carbohydrate kinase activity
AVJ22_RS12260	COG1846	Transcriptional regulator
AVJ22_RS12265	COG2115	Belongs to the xylose isomerase family
AVJ22_RS12270	COG1070	Carbohydrate kinase
AVJ22_RS12275	COG2814	Major facilitator Superfamily
AVJ22_RS12275	COG0477	Major facilitator Superfamily
AVJ22_RS12285	COG2188	Transcriptional regulator
AVJ22_RS12305	COG3964	amidohydrolase
AVJ22_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS12315	COG1250	3-hydroxyacyl-CoA dehydrogenase
AVJ22_RS12320	COG2610	gluconate transmembrane transporter activity
AVJ22_RS12325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVJ22_RS12330	COG1609	Transcriptional regulator
AVJ22_RS12340	COG1131	(ABC) transporter
AVJ22_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVJ22_RS12350	COG2210	Belongs to the sulfur carrier protein TusA family
AVJ22_RS12355	COG1937	Protein conserved in bacteria
AVJ22_RS12360	COG0730	response to heat
AVJ22_RS12380	COG2160	L-arabinose isomerase activity
AVJ22_RS12385	COG0235	Class ii aldolase
AVJ22_RS12395	COG1609	Transcriptional regulator
AVJ22_RS12400	COG1609	Transcriptional regulator
AVJ22_RS12405	COG4975	Glucose uptake
AVJ22_RS12430	COG1054	Belongs to the UPF0176 family
AVJ22_RS12445	COG1388	LysM domain
AVJ22_RS12450	COG0564	pseudouridine synthase activity
AVJ22_RS12455	COG1388	LysM domain
AVJ22_RS12460	COG2318	DinB family
AVJ22_RS12470	COG1012	belongs to the aldehyde dehydrogenase family
AVJ22_RS12480	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS12485	COG3192	ethanolamine utilization protein
AVJ22_RS12500	COG1349	DNA-binding transcription factor activity
AVJ22_RS12515	COG3414	Phosphotransferase system galactitol-specific IIB component
AVJ22_RS12520	COG3775	system Galactitol-specific IIC component
AVJ22_RS12525	COG1063	alcohol dehydrogenase
AVJ22_RS12530	COG1063	alcohol dehydrogenase
AVJ22_RS12535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AVJ22_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
AVJ22_RS12555	COG1695	Transcriptional regulator
AVJ22_RS12560	COG2059	Chromate
AVJ22_RS12575	COG0494	nUDIX hydrolase
AVJ22_RS12580	COG0556	nucleotide-excision repair
AVJ22_RS12590	COG1475	DNA binding
AVJ22_RS12595	COG0019	diaminopimelate decarboxylase activity
AVJ22_RS12605	COG4264	IucA IucC family
AVJ22_RS12610	COG4264	IucA IucC family
AVJ22_RS12615	COG2814	Major facilitator Superfamily
AVJ22_RS12620	COG4264	IucA IucC family
AVJ22_RS12625	COG2423	ornithine cyclodeaminase activity
AVJ22_RS12635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVJ22_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS12645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVJ22_RS12655	COG0415	Belongs to the DNA photolyase family
AVJ22_RS12660	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AVJ22_RS12690	COG0702	epimerase
AVJ22_RS12705	COG1846	Transcriptional regulator
AVJ22_RS12720	COG1607	acyl-coa hydrolase
AVJ22_RS12725	COG0583	DNA-binding transcription factor activity
AVJ22_RS12735	COG3250	beta-galactosidase activity
AVJ22_RS12740	COG2211	Major facilitator Superfamily
AVJ22_RS12745	COG2207	Transcriptional regulator
AVJ22_RS12755	COG0535	radical SAM domain protein
AVJ22_RS12760	COG1994	Peptidase M50
AVJ22_RS12765	COG1131	(ABC) transporter
AVJ22_RS12775	COG0673	inositol 2-dehydrogenase activity
AVJ22_RS12780	COG0561	phosphatase activity
AVJ22_RS12785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AVJ22_RS12790	COG1609	Transcriptional regulator
AVJ22_RS12795	COG1942	4-Oxalocrotonate Tautomerase
AVJ22_RS12815	COG3759	membrane
AVJ22_RS12825	COG2130	NADP-dependent
AVJ22_RS12835	COG4145	pantothenate transmembrane transporter activity
AVJ22_RS12850	COG1215	transferase activity, transferring glycosyl groups
AVJ22_RS12855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVJ22_RS12875	COG0523	cobalamin synthesis protein
AVJ22_RS12880	COG0281	malic enzyme
AVJ22_RS12885	COG3493	citrate carrier protein
AVJ22_RS12890	COG4565	transcriptional regulatory protein
AVJ22_RS12895	COG3290	protein histidine kinase activity
AVJ22_RS12900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVJ22_RS12905	COG1064	alcohol dehydrogenase
AVJ22_RS12935	COG0702	epimerase
AVJ22_RS12945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AVJ22_RS12950	COG1733	regulation of RNA biosynthetic process
AVJ22_RS12955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AVJ22_RS12960	COG0697	spore germination
AVJ22_RS12965	COG1063	alcohol dehydrogenase
AVJ22_RS12970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVJ22_RS12975	COG0693	protein deglycase activity
AVJ22_RS12980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVJ22_RS12990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AVJ22_RS13000	COG3961	Belongs to the TPP enzyme family
AVJ22_RS13040	COG0415	Belongs to the DNA photolyase family
AVJ22_RS13075	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AVJ22_RS13080	COG0702	epimerase
AVJ22_RS13095	COG2130	NADP-dependent
AVJ22_RS13100	COG0702	epimerase
AVJ22_RS13110	COG0789	Transcriptional regulator
AVJ22_RS13125	COG1705	Flagellar rod assembly protein muramidase FlgJ
AVJ22_RS13125	COG3942	CHAP domain
AVJ22_RS13135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AVJ22_RS13140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AVJ22_RS13150	COG4863	YycH protein
AVJ22_RS13155	COG5002	protein histidine kinase activity
AVJ22_RS13160	COG0745	RESPONSE REGULATOR receiver
AVJ22_RS13165	COG0477	Major facilitator Superfamily
AVJ22_RS13185	COG1819	glycosyl
AVJ22_RS13190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVJ22_RS13195	COG0305	Participates in initiation and elongation during chromosome replication
AVJ22_RS13200	COG0359	binds to the 23S rRNA
AVJ22_RS13205	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AVJ22_RS13215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVJ22_RS13225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AVJ22_RS13230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVJ22_RS13235	COG2986	histidine ammonia-lyase
AVJ22_RS13240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVJ22_RS13250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVJ22_RS13255	COG0187	DNA topoisomerase II activity
AVJ22_RS13260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVJ22_RS13265	COG2501	S4 domain
AVJ22_RS13270	COG0592	DNA-directed DNA polymerase activity
AVJ22_RS13275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVJ22_RS13290	COG0594	ribonuclease P activity
AVJ22_RS13490	COG4670	ketone body catabolic process
AVJ22_RS13530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVJ22_RS13785	COG3386	PFAM SMP-30 Gluconolaconase
AVJ22_RS13990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34