locus-tag	class	description
I6J06_RS00020	COG0300	oxidoreductase activity
I6J06_RS00030	COG2211	Major facilitator Superfamily
I6J06_RS00035	COG1486	melibiose metabolic process
I6J06_RS00040	COG2169	Transcriptional regulator
I6J06_RS00045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J06_RS00050	COG3002	Belongs to the UPF0753 family
I6J06_RS00055	COG5609	conserved protein (DUF2294)
I6J06_RS00060	COG0668	transmembrane transport
I6J06_RS00065	COG4481	Protein conserved in bacteria
I6J06_RS00070	COG0012	GTP binding
I6J06_RS00080	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J06_RS00090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J06_RS00115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J06_RS00120	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J06_RS00125	COG2723	6-phospho-beta-galactosidase activity
I6J06_RS00135	COG4195	phage-related replication protein
I6J06_RS00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J06_RS00165	COG2076	Multidrug Resistance protein
I6J06_RS00170	COG2076	Multidrug Resistance protein
I6J06_RS00175	COG1280	lysine exporter protein (LysE YggA)
I6J06_RS00185	COG0588	phosphoglycerate mutase activity
I6J06_RS00200	COG3634	alkyl hydroperoxide reductase activity
I6J06_RS00205	COG0450	alkyl hydroperoxide reductase
I6J06_RS00220	COG3279	Response regulator of the LytR AlgR family
I6J06_RS00225	COG3620	sequence-specific DNA binding
I6J06_RS00230	COG0753	catalase activity
I6J06_RS00240	COG0778	Nitroreductase
I6J06_RS00250	COG1823	symporter activity
I6J06_RS00255	COG5183	chlorophyll binding
I6J06_RS00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J06_RS00275	COG2233	PERMEase
I6J06_RS00280	COG0517	IMP dehydrogenase activity
I6J06_RS00280	COG0516	GMP reductase activity
I6J06_RS00285	COG0519	Catalyzes the synthesis of GMP from XMP
I6J06_RS00285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J06_RS00345	COG2814	Major facilitator Superfamily
I6J06_RS00350	COG0583	DNA-binding transcription factor activity
I6J06_RS00360	COG1595	DNA-templated transcription, initiation
I6J06_RS00370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J06_RS00380	COG0406	alpha-ribazole phosphatase activity
I6J06_RS00385	COG2807	transmembrane transport
I6J06_RS00390	COG4195	phage-related replication protein
I6J06_RS00405	COG5646	InterPro IPR014922
I6J06_RS00410	COG1114	Component of the transport system for branched-chain amino acids
I6J06_RS00415	COG0733	neurotransmitter:sodium symporter activity
I6J06_RS00420	COG0129	dihydroxy-acid dehydratase activity
I6J06_RS00430	COG1388	LysM domain
I6J06_RS00430	COG3942	CHAP domain
I6J06_RS00445	COG0004	ammonium transporteR
I6J06_RS00460	COG0583	DNA-binding transcription factor activity
I6J06_RS00465	COG0070	glutamate synthase
I6J06_RS00465	COG0069	glutamate synthase activity
I6J06_RS00465	COG0067	glutamate synthase
I6J06_RS00470	COG0493	'glutamate synthase
I6J06_RS00480	COG1263	PTS System
I6J06_RS00480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS00485	COG0366	Alpha amylase catalytic
I6J06_RS00490	COG2188	Transcriptional regulator
I6J06_RS00500	COG3153	acetyltransferase
I6J06_RS00505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J06_RS00510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J06_RS00515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J06_RS00550	COG1982	Orn Lys Arg decarboxylase major
I6J06_RS00555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J06_RS00560	COG3870	Protein conserved in bacteria
I6J06_RS00565	COG0470	DNA polymerase III
I6J06_RS00570	COG1774	PSP1 C-terminal conserved region
I6J06_RS00575	COG4467	Involved in initiation control of chromosome replication
I6J06_RS00580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J06_RS00585	COG2827	Endonuclease containing a URI domain
I6J06_RS00590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J06_RS00595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J06_RS00595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J06_RS00600	COG0084	hydrolase, TatD family'
I6J06_RS00605	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6J06_RS00610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J06_RS00615	COG4466	Protein conserved in bacteria
I6J06_RS00620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J06_RS00625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J06_RS00630	COG0251	oxidation-reduction process
I6J06_RS00635	COG2088	sporulation resulting in formation of a cellular spore
I6J06_RS00640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J06_RS00645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J06_RS00650	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J06_RS00655	COG0193	aminoacyl-tRNA hydrolase activity
I6J06_RS00660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J06_RS00665	COG2244	polysaccharide biosynthetic process
I6J06_RS00670	COG3956	TIGRFAM MazG family protein
I6J06_RS00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J06_RS00685	COG1098	S1 RNA binding domain
I6J06_RS00700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J06_RS00705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J06_RS00725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J06_RS00730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J06_RS00815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J06_RS00820	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J06_RS00825	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J06_RS00830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J06_RS00835	COG4463	regulation of RNA biosynthetic process
I6J06_RS00840	COG3880	PFAM UvrB UvrC protein
I6J06_RS00845	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6J06_RS00850	COG0542	response to heat
I6J06_RS00855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J06_RS00860	COG4956	integral membrane protein (PIN domain superfamily)
I6J06_RS00865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J06_RS00870	COG1045	serine acetyltransferase
I6J06_RS00875	COG0215	cysteine-tRNA ligase activity
I6J06_RS00880	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6J06_RS00885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J06_RS00890	COG3688	RNA-binding protein containing a PIN domain
I6J06_RS00900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J06_RS00910	COG0250	Participates in transcription elongation, termination and antitermination
I6J06_RS00915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J06_RS00920	COG0081	regulation of translation
I6J06_RS00925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J06_RS00935	COG2813	Specifically methylates the guanine in position
I6J06_RS00940	COG0085	RNA polymerase activity
I6J06_RS00945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J06_RS00955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J06_RS00960	COG0049	tRNA binding
I6J06_RS00965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J06_RS00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J06_RS00975	COG1473	amidohydrolase
I6J06_RS00990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J06_RS00990	COG1215	transferase activity, transferring glycosyl groups
I6J06_RS01005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J06_RS01010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J06_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS01050	COG0583	DNA-binding transcription factor activity
I6J06_RS01060	COG0800	Aldolase
I6J06_RS01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J06_RS01085	COG1904	glucuronate isomerase
I6J06_RS01090	COG1312	Catalyzes the dehydration of D-mannonate
I6J06_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS01100	COG1132	(ABC) transporter
I6J06_RS01105	COG1069	ribulokinase activity
I6J06_RS01110	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J06_RS01115	COG0010	Belongs to the arginase family
I6J06_RS01125	COG0833	amino acid
I6J06_RS01130	COG2040	homocysteine
I6J06_RS01135	COG3239	Fatty acid desaturase
I6J06_RS01150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J06_RS01160	COG0667	Aldo Keto reductase
I6J06_RS01175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J06_RS01220	COG0706	membrane insertase activity
I6J06_RS01235	COG1682	transport, permease protein
I6J06_RS01245	COG1902	pentaerythritol trinitrate reductase activity
I6J06_RS01250	COG1733	regulation of RNA biosynthetic process
I6J06_RS01260	COG1486	melibiose metabolic process
I6J06_RS01265	COG2211	Major facilitator Superfamily
I6J06_RS01270	COG4221	oxidoreductase activity
I6J06_RS01275	COG0604	alcohol dehydrogenase
I6J06_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS01325	COG1279	arginine transmembrane transporter activity
I6J06_RS01335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J06_RS01340	COG1733	regulation of RNA biosynthetic process
I6J06_RS01345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J06_RS01370	COG0702	epimerase
I6J06_RS01375	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6J06_RS01410	COG0415	Belongs to the DNA photolyase family
I6J06_RS01420	COG1136	(ABC) transporter
I6J06_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS01470	COG0546	phosphoglycolate phosphatase activity
I6J06_RS01480	COG1428	Deoxynucleoside kinase
I6J06_RS01485	COG1428	Deoxynucleoside kinase
I6J06_RS01495	COG0561	phosphatase activity
I6J06_RS01500	COG0431	NADPH-dependent FMN reductase
I6J06_RS01515	COG1469	GTP cyclohydrolase I activity
I6J06_RS01520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J06_RS01530	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J06_RS01540	COG1115	amino acid carrier protein
I6J06_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
I6J06_RS01550	COG0183	Belongs to the thiolase family
I6J06_RS01585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J06_RS01595	COG2363	Small membrane protein
I6J06_RS01610	COG2966	Psort location CytoplasmicMembrane, score
I6J06_RS01615	COG3253	May function as heme-dependent peroxidase
I6J06_RS01620	COG0280	phosphate acetyltransferase
I6J06_RS01625	COG0095	Lipoate-protein ligase
I6J06_RS01630	COG0083	homoserine kinase activity
I6J06_RS01645	COG1263	PTS System
I6J06_RS01645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS01650	COG1737	Transcriptional regulator
I6J06_RS01655	COG0673	inositol 2-dehydrogenase activity
I6J06_RS01665	COG0673	inositol 2-dehydrogenase activity
I6J06_RS01670	COG1082	Xylose isomerase domain protein TIM barrel
I6J06_RS01675	COG4844	belongs to the
I6J06_RS01680	COG0667	Aldo Keto reductase
I6J06_RS01685	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J06_RS01690	COG0456	acetyltransferase
I6J06_RS01695	COG1078	dGTPase activity
I6J06_RS01710	COG0018	arginyl-trna synthetase
I6J06_RS01715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J06_RS01720	COG0789	Transcriptional regulator
I6J06_RS01725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS01730	COG4139	cobalamin transport
I6J06_RS01735	COG0546	phosphoglycolate phosphatase activity
I6J06_RS01755	COG0596	Alpha beta hydrolase
I6J06_RS01790	COG4974	Belongs to the 'phage' integrase family
I6J06_RS01795	COG2111	Na H antiporter
I6J06_RS01795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J06_RS01800	COG2111	Na H antiporter
I6J06_RS01805	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J06_RS01810	COG0651	ATP synthesis coupled electron transport
I6J06_RS01815	COG1863	multisubunit Na H antiporter MnhE subunit
I6J06_RS01820	COG2212	antiporter activity
I6J06_RS01825	COG1320	monovalent cation:proton antiporter activity
I6J06_RS01835	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J06_RS01840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J06_RS01845	COG1121	(ABC) transporter
I6J06_RS01860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6J06_RS01865	COG1134	teichoic acid transport
I6J06_RS01870	COG1682	transport, permease protein
I6J06_RS01875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J06_RS01885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J06_RS01895	COG1132	(ABC) transporter
I6J06_RS01900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J06_RS01905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J06_RS01910	COG1120	ATPase activity
I6J06_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS01925	COG2376	Dihydroxyacetone kinase
I6J06_RS01930	COG1461	Dihydroxyacetone kinase
I6J06_RS01935	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J06_RS01945	COG3949	Membrane
I6J06_RS01960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J06_RS01965	COG0745	RESPONSE REGULATOR receiver
I6J06_RS01970	COG2205	protein histidine kinase activity
I6J06_RS01975	COG1392	Phosphate transport regulator
I6J06_RS01980	COG0306	phosphate transporter
I6J06_RS01985	COG3942	CHAP domain
I6J06_RS01985	COG1388	LysM domain
I6J06_RS02000	COG0217	transcriptional regulatory protein
I6J06_RS02010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J06_RS02020	COG0583	DNA-binding transcription factor activity
I6J06_RS02030	COG2839	Protein conserved in bacteria
I6J06_RS02035	COG2814	Major facilitator Superfamily
I6J06_RS02065	COG1279	arginine transmembrane transporter activity
I6J06_RS02070	COG1611	Belongs to the LOG family
I6J06_RS02075	COG1671	Belongs to the UPF0178 family
I6J06_RS02085	COG1968	undecaprenyl-diphosphatase activity
I6J06_RS02090	COG4988	ABC transporter
I6J06_RS02095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J06_RS02105	COG0523	cobalamin synthesis protein
I6J06_RS02110	COG4989	oxidoreductase activity
I6J06_RS02120	COG0586	Pfam SNARE associated Golgi protein
I6J06_RS02125	COG0039	L-malate dehydrogenase activity
I6J06_RS02150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J06_RS02155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J06_RS02160	COG1349	DNA-binding transcription factor activity
I6J06_RS02165	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J06_RS02170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J06_RS02170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS02170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J06_RS02175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J06_RS02180	COG1253	flavin adenine dinucleotide binding
I6J06_RS02185	COG0656	L-ascorbic acid biosynthetic process
I6J06_RS02190	COG0463	Glycosyl transferase, family 2
I6J06_RS02205	COG0602	queuosine metabolic process
I6J06_RS02210	COG0720	synthase
I6J06_RS02215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J06_RS02220	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J06_RS02225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J06_RS02240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J06_RS02250	COG1368	sulfuric ester hydrolase activity
I6J06_RS02260	COG0488	(ABC) transporter
I6J06_RS02265	COG0514	ATP-dependent DNA helicase (RecQ)
I6J06_RS02275	COG1174	glycine betaine transport
I6J06_RS02280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J06_RS02290	COG1597	lipid kinase activity
I6J06_RS02295	COG3104	oligopeptide transport
I6J06_RS02300	COG3104	oligopeptide transport
I6J06_RS02305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J06_RS02315	COG1780	Probably involved in ribonucleotide reductase function
I6J06_RS02320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J06_RS02325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J06_RS02330	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS02335	COG4605	iron ion homeostasis
I6J06_RS02340	COG4604	ABC transporter, ATP-binding protein
I6J06_RS02345	COG4607	ABC-type enterochelin transport system periplasmic component
I6J06_RS02360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J06_RS02380	COG1929	Belongs to the glycerate kinase type-1 family
I6J06_RS02385	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J06_RS02400	COG2199	diguanylate cyclase activity
I6J06_RS02405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J06_RS02410	COG1739	Uncharacterized protein family UPF0029
I6J06_RS02420	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J06_RS02425	COG1040	competence protein
I6J06_RS02430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J06_RS02435	COG0653	protein targeting
I6J06_RS02445	COG3942	CHAP domain
I6J06_RS02445	COG1388	LysM domain
I6J06_RS02460	COG0556	nucleotide-excision repair
I6J06_RS02465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J06_RS02470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6J06_RS02475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J06_RS02480	COG0110	maltose O-acetyltransferase activity
I6J06_RS02495	COG1660	Displays ATPase and GTPase activities
I6J06_RS02500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J06_RS02505	COG1481	regulation of sporulation
I6J06_RS02510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J06_RS02520	COG0740	serine-type endopeptidase activity
I6J06_RS02525	COG1090	epimerase
I6J06_RS02555	COG0126	phosphoglycerate kinase activity
I6J06_RS02560	COG0149	triose-phosphate isomerase activity
I6J06_RS02565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J06_RS02570	COG0148	phosphopyruvate hydratase activity
I6J06_RS02580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J06_RS02585	COG1647	Serine aminopeptidase, S33
I6J06_RS02590	COG0557	exoribonuclease II activity
I6J06_RS02595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J06_RS02780	COG0384	phenazine biosynthesis protein PhzF
I6J06_RS02805	COG1278	Cold shock
I6J06_RS02850	COG0346	lactoylglutathione lyase activity
I6J06_RS02895	COG2314	TM2 domain
I6J06_RS02910	COG2851	Citrate transporter
I6J06_RS02925	COG1764	response to oxidative stress
I6J06_RS02930	COG0710	3-dehydroquinate dehydratase activity
I6J06_RS02935	COG0778	Nitroreductase
I6J06_RS02940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J06_RS02945	COG1393	Belongs to the ArsC family
I6J06_RS02950	COG0509	glycine decarboxylation via glycine cleavage system
I6J06_RS02955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6J06_RS02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J06_RS02965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J06_RS02970	COG2011	ABC-type metal ion transport system permease component
I6J06_RS02975	COG1464	Belongs to the NlpA lipoprotein family
I6J06_RS02980	COG1253	flavin adenine dinucleotide binding
I6J06_RS02990	COG0396	ATPase activity
I6J06_RS02995	COG0719	Fe-S assembly protein
I6J06_RS03000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J06_RS03005	COG0822	iron-sulfur transferase activity
I6J06_RS03010	COG0719	Fe-S assembly protein
I6J06_RS03015	COG4536	flavin adenine dinucleotide binding
I6J06_RS03020	COG2070	2-Nitropropane dioxygenase
I6J06_RS03025	COG1801	Protein of unknown function DUF72
I6J06_RS03030	COG0730	response to heat
I6J06_RS03035	COG0737	Belongs to the 5'-nucleotidase family
I6J06_RS03040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J06_RS03045	COG4470	Protein conserved in bacteria
I6J06_RS03055	COG2445	Protein of unknown function DUF86
I6J06_RS03060	COG0647	UMP catabolic process
I6J06_RS03080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J06_RS03085	COG1696	Membrane protein involved in D-alanine export
I6J06_RS03090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J06_RS03095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6J06_RS03100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6J06_RS03105	COG4837	Protein of unknown function (DUF1462)
I6J06_RS03110	COG1252	NADH dehydrogenase
I6J06_RS03115	COG4844	belongs to the
I6J06_RS03120	COG0316	Belongs to the HesB IscA family
I6J06_RS03125	COG1252	NADH dehydrogenase
I6J06_RS03130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J06_RS03135	COG2056	Na+-H+ antiporter family
I6J06_RS03140	COG2050	protein possibly involved in aromatic compounds catabolism
I6J06_RS03150	COG1320	monovalent cation:proton antiporter activity
I6J06_RS03155	COG2212	antiporter activity
I6J06_RS03160	COG1863	multisubunit Na H antiporter MnhE subunit
I6J06_RS03165	COG0651	ATP synthesis coupled electron transport
I6J06_RS03170	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J06_RS03175	COG2111	Na H antiporter
I6J06_RS03180	COG2111	Na H antiporter
I6J06_RS03180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J06_RS03190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J06_RS03195	COG1098	S1 RNA binding domain
I6J06_RS03200	COG1902	pentaerythritol trinitrate reductase activity
I6J06_RS03205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J06_RS03225	COG2832	Protein of unknown function (DUF454)
I6J06_RS03230	COG0584	glycerophosphoryl diester phosphodiesterase
I6J06_RS03235	COG0165	Argininosuccinate lyase
I6J06_RS03240	COG0137	argininosuccinate synthase activity
I6J06_RS03245	COG0166	Belongs to the GPI family
I6J06_RS03250	COG0398	Pfam SNARE associated Golgi protein
I6J06_RS03265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J06_RS03270	COG1074	ATP-dependent DNA helicase activity
I6J06_RS03275	COG2311	Membrane
I6J06_RS03280	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J06_RS03290	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J06_RS03295	COG0561	phosphatase activity
I6J06_RS03315	COG0542	response to heat
I6J06_RS03325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J06_RS03345	COG0601	transmembrane transport
I6J06_RS03350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J06_RS03355	COG0444	Belongs to the ABC transporter superfamily
I6J06_RS03360	COG4608	Belongs to the ABC transporter superfamily
I6J06_RS03365	COG4166	transmembrane transport
I6J06_RS03370	COG0180	Tryptophanyl-tRNA synthetase
I6J06_RS03375	COG1393	Belongs to the ArsC family
I6J06_RS03380	COG4862	establishment of competence for transformation
I6J06_RS03390	COG1164	Oligoendopeptidase f
I6J06_RS03395	COG2910	NAD(P)H-binding
I6J06_RS03400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J06_RS03405	COG2346	COG2346, Truncated hemoglobins
I6J06_RS03410	COG4116	CYTH
I6J06_RS03420	COG2357	RelA SpoT domain protein
I6J06_RS03425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J06_RS03430	COG0564	pseudouridine synthase activity
I6J06_RS03435	COG2239	Acts as a magnesium transporter
I6J06_RS03440	COG0475	glutathione-regulated potassium exporter activity
I6J06_RS03440	COG0569	domain protein
I6J06_RS03450	COG0628	permease
I6J06_RS03455	COG1115	amino acid carrier protein
I6J06_RS03460	COG2382	esterase
I6J06_RS03465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6J06_RS03470	COG2814	Major facilitator Superfamily
I6J06_RS03475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J06_RS03480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J06_RS03490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J06_RS03495	COG0861	Integral membrane protein TerC family
I6J06_RS03500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J06_RS03505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J06_RS03510	COG0737	Belongs to the 5'-nucleotidase family
I6J06_RS03520	COG4873	Protein conserved in bacteria
I6J06_RS03535	COG4903	ComK protein
I6J06_RS03555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J06_RS03560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J06_RS03570	COG2314	TM2 domain
I6J06_RS03580	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J06_RS03585	COG1169	isochorismate synthase
I6J06_RS03590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J06_RS03600	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J06_RS03610	COG0436	Aminotransferase
I6J06_RS03615	COG3594	Acyltransferase
I6J06_RS03640	COG1316	TRANSCRIPTIONal
I6J06_RS03645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J06_RS03660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J06_RS03665	COG1845	cytochrome c oxidase, subunit III
I6J06_RS03670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J06_RS03675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J06_RS03690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J06_RS03695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J06_RS03700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J06_RS03705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J06_RS03710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J06_RS03715	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J06_RS03720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J06_RS03730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J06_RS03740	COG0138	bifunctional purine biosynthesis protein purh
I6J06_RS03745	COG0151	Belongs to the GarS family
I6J06_RS03755	COG4172	Belongs to the ABC transporter superfamily
I6J06_RS03775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J06_RS03785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS03790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J06_RS03800	COG1271	oxidase subunit
I6J06_RS03805	COG1294	oxidase, subunit
I6J06_RS03810	COG0569	domain protein
I6J06_RS03815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J06_RS03820	COG5503	Protein of unknown function (DUF1447)
I6J06_RS03830	COG0242	peptide deformylase activity
I6J06_RS03850	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J06_RS03860	COG4476	Belongs to the UPF0223 family
I6J06_RS03865	COG3842	ATPase activity
I6J06_RS03875	COG1177	transmembrane transport
I6J06_RS03895	COG4493	Belongs to the UPF0637 family
I6J06_RS03900	COG0483	inositol monophosphate 1-phosphatase activity
I6J06_RS03910	COG1217	gtp-binding protein TYPA
I6J06_RS03915	COG4896	Protein conserved in bacteria
I6J06_RS03920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J06_RS03925	COG4838	Belongs to the UPF0358 family
I6J06_RS03930	COG0772	Belongs to the SEDS family
I6J06_RS03940	COG1612	heme a metabolic process
I6J06_RS03945	COG0109	protoheme IX farnesyltransferase activity
I6J06_RS03965	COG3679	Belongs to the UPF0342 family
I6J06_RS03975	COG4471	UPF0298 protein
I6J06_RS03985	COG0742	ribosomal rna small subunit methyltransferase
I6J06_RS03990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J06_RS03995	COG1323	Belongs to the UPF0348 family
I6J06_RS04005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J06_RS04015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J06_RS04020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J06_RS04025	COG0072	phenylalanine-tRNA ligase activity
I6J06_RS04030	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J06_RS04035	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6J06_RS04045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J06_RS04045	COG1796	DNA polymerase
I6J06_RS04050	COG1193	negative regulation of DNA recombination
I6J06_RS04055	COG3118	belongs to the thioredoxin family
I6J06_RS04060	COG0322	excinuclease ABC activity
I6J06_RS04065	COG2009	succinate dehydrogenase
I6J06_RS04070	COG1053	succinate dehydrogenase
I6J06_RS04075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J06_RS04080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J06_RS04115	COG0584	glycerophosphoryl diester phosphodiesterase
I6J06_RS04145	COG1011	Hydrolase
I6J06_RS04150	COG0454	-acetyltransferase
I6J06_RS04155	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6J06_RS04160	COG2001	Belongs to the MraZ family
I6J06_RS04165	COG0275	rRNA processing
I6J06_RS04170	COG4839	cell division protein FtsL
I6J06_RS04175	COG0768	penicillin binding
I6J06_RS04180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J06_RS04185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J06_RS04190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J06_RS04195	COG0849	cell division
I6J06_RS04200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J06_RS04205	COG1496	oxidoreductase activity
I6J06_RS04210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J06_RS04215	COG1799	cell septum assembly
I6J06_RS04220	COG0762	integral membrane protein
I6J06_RS04225	COG2302	S4 RNA-binding domain
I6J06_RS04230	COG3599	regulation of cell shape
I6J06_RS04235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J06_RS04245	COG3942	CHAP domain
I6J06_RS04245	COG1388	LysM domain
I6J06_RS04250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J06_RS04255	COG0564	pseudouridine synthase activity
I6J06_RS04260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J06_RS04265	COG2233	PERMEase
I6J06_RS04270	COG0540	Belongs to the ATCase OTCase family
I6J06_RS04280	COG0505	Belongs to the CarA family
I6J06_RS04285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J06_RS04290	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J06_RS04295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J06_RS04305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J06_RS04315	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6J06_RS04320	COG0194	GDP metabolic process
I6J06_RS04325	COG1758	RNA polymerase activity
I6J06_RS04330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J06_RS04335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J06_RS04350	COG0242	peptide deformylase activity
I6J06_RS04355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J06_RS04360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J06_RS04360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J06_RS04365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J06_RS04370	COG0631	protein serine/threonine phosphatase activity
I6J06_RS04385	COG1162	GTPase activity
I6J06_RS04390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J06_RS04395	COG1564	THIamine pyrophosphokinase
I6J06_RS04400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J06_RS04405	COG1302	Protein conserved in bacteria
I6J06_RS04410	COG1461	Dihydroxyacetone kinase
I6J06_RS04415	COG1760	l-serine dehydratase
I6J06_RS04420	COG1760	l-serine dehydratase
I6J06_RS04425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J06_RS04435	COG1349	DNA-binding transcription factor activity
I6J06_RS04440	COG0416	fatty acid biosynthetic process
I6J06_RS04455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J06_RS04460	COG0571	ribonuclease III activity
I6J06_RS04465	COG1196	nuclear chromosome segregation
I6J06_RS04470	COG0552	protein localization to endoplasmic reticulum
I6J06_RS04475	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6J06_RS04480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J06_RS04485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS04495	COG0228	four-way junction DNA binding
I6J06_RS04500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J06_RS04505	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J06_RS04510	COG0335	large ribosomal subunit rRNA binding
I6J06_RS04520	COG4485	Bacterial membrane protein, YfhO
I6J06_RS04530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J06_RS04535	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J06_RS04545	COG0758	DNA mediated transformation
I6J06_RS04550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J06_RS04555	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6J06_RS04560	COG4974	Belongs to the 'phage' integrase family
I6J06_RS04565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6J06_RS04570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6J06_RS04575	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J06_RS04580	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J06_RS04585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J06_RS04590	COG0528	UMP kinase activity
I6J06_RS04595	COG0233	cytoplasmic translational termination
I6J06_RS04600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J06_RS04605	COG4589	Belongs to the CDS family
I6J06_RS04615	COG0442	prolyl-tRNA aminoacylation
I6J06_RS04620	COG2176	DNA-directed DNA polymerase activity
I6J06_RS04625	COG0779	Required for maturation of 30S ribosomal subunits
I6J06_RS04630	COG0195	Participates in both transcription termination and antitermination
I6J06_RS04635	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J06_RS04640	COG1358	cellular component organization or biogenesis
I6J06_RS04645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J06_RS04660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J06_RS04665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J06_RS04670	COG0196	riboflavin kinase activity
I6J06_RS04675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J06_RS04680	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J06_RS04685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J06_RS04690	COG1674	ftsk spoiiie
I6J06_RS04695	COG2188	Transcriptional regulator
I6J06_RS04700	COG0612	Peptidase, M16
I6J06_RS04705	COG0612	Peptidase, M16
I6J06_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS04730	COG1058	Belongs to the CinA family
I6J06_RS04730	COG1546	Belongs to the CinA family
I6J06_RS04735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J06_RS04740	COG1418	mRNA catabolic process
I6J06_RS04750	COG1692	metallophosphoesterase
I6J06_RS04755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J06_RS04755	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J06_RS04760	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J06_RS04770	COG1959	2 iron, 2 sulfur cluster binding
I6J06_RS04775	COG0492	ferredoxin-NADP+ reductase activity
I6J06_RS04785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J06_RS04790	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6J06_RS04800	COG2207	Transcriptional regulator
I6J06_RS04810	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J06_RS04815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J06_RS04820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J06_RS04830	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J06_RS04835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J06_RS04840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J06_RS04845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J06_RS04870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J06_RS04875	COG1923	regulation of RNA biosynthetic process
I6J06_RS04880	COG0386	Belongs to the glutathione peroxidase family
I6J06_RS04885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J06_RS04890	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6J06_RS04895	COG0789	Transcriptional regulator
I6J06_RS04900	COG0174	glutamine synthetase
I6J06_RS04940	COG0527	aspartate kinase activity
I6J06_RS04945	COG0460	homoserine dehydrogenase
I6J06_RS04950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J06_RS04955	COG0083	homoserine kinase activity
I6J06_RS04970	COG0833	amino acid
I6J06_RS04975	COG0753	catalase activity
I6J06_RS04985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J06_RS04990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J06_RS04995	COG0516	GMP reductase activity
I6J06_RS05005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J06_RS05025	COG3763	UPF0154 protein
I6J06_RS05035	COG4846	Membrane protein involved in cytochrome C biogenesis
I6J06_RS05040	COG0420	3'-5' exonuclease activity
I6J06_RS05045	COG0419	ATPase involved in DNA repair
I6J06_RS05050	COG1970	mechanosensitive ion channel activity
I6J06_RS05055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J06_RS05060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J06_RS05070	COG4841	protein insertion into membrane
I6J06_RS05075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J06_RS05085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J06_RS05090	COG1115	amino acid carrier protein
I6J06_RS05095	COG3711	transcriptional antiterminator
I6J06_RS05105	COG0628	permease
I6J06_RS05110	COG0392	lysyltransferase activity
I6J06_RS05110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J06_RS05120	COG1609	Transcriptional regulator
I6J06_RS05125	COG1869	D-ribose catabolic process
I6J06_RS05130	COG1129	ABC transporter
I6J06_RS05135	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J06_RS05140	COG1879	ABC-type sugar transport system periplasmic component
I6J06_RS05155	COG1942	4-Oxalocrotonate Tautomerase
I6J06_RS05160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J06_RS05165	COG0287	Prephenate dehydrogenase
I6J06_RS05175	COG1363	Peptidase, m42
I6J06_RS05190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J06_RS05195	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J06_RS05200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J06_RS05205	COG0134	indole-3-glycerol-phosphate synthase activity
I6J06_RS05215	COG0133	tryptophan synthase activity
I6J06_RS05220	COG0159	tryptophan synthase activity
I6J06_RS05250	COG1164	Oligoendopeptidase f
I6J06_RS05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J06_RS05265	COG0581	inorganic phosphate transmembrane transporter activity
I6J06_RS05270	COG0573	inorganic phosphate transmembrane transporter activity
I6J06_RS05275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J06_RS05280	COG2996	Protein conserved in bacteria
I6J06_RS05285	COG0488	(ABC) transporter
I6J06_RS05295	COG0527	aspartate kinase activity
I6J06_RS05300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J06_RS05305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J06_RS05310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J06_RS05320	COG1473	amidohydrolase
I6J06_RS05335	COG1278	Cold shock
I6J06_RS05345	COG1254	Belongs to the acylphosphatase family
I6J06_RS05355	COG3853	Toxic anion resistance protein (TelA)
I6J06_RS05360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J06_RS05365	COG1114	Component of the transport system for branched-chain amino acids
I6J06_RS05370	COG4548	von Willebrand factor, type A
I6J06_RS05375	COG0714	Associated with various cellular activities
I6J06_RS05395	COG4152	abc transporter atp-binding protein
I6J06_RS05400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J06_RS05405	COG0673	inositol 2-dehydrogenase activity
I6J06_RS05415	COG1082	Xylose isomerase domain protein TIM barrel
I6J06_RS05425	COG2207	Transcriptional regulator
I6J06_RS05425	COG1917	Cupin 2, conserved barrel domain protein
I6J06_RS05435	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J06_RS05440	COG0567	Dehydrogenase, E1 component
I6J06_RS05445	COG5002	protein histidine kinase activity
I6J06_RS05450	COG0745	RESPONSE REGULATOR receiver
I6J06_RS05455	COG0671	phosphoesterase, PA-phosphatase related
I6J06_RS05460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J06_RS05470	COG0793	Belongs to the peptidase S41A family
I6J06_RS05475	COG4479	Belongs to the UPF0346 family
I6J06_RS05485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J06_RS05505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J06_RS05515	COG1413	lyase activity
I6J06_RS05520	COG1413	lyase activity
I6J06_RS05530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J06_RS05540	COG0328	RNA-DNA hybrid ribonuclease activity
I6J06_RS05545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J06_RS05550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J06_RS05560	COG2962	Rard protein
I6J06_RS05565	COG0116	Belongs to the methyltransferase superfamily
I6J06_RS05580	COG4474	Belongs to the UPF0398 family
I6J06_RS05590	COG3331	DNA recombination
I6J06_RS05595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J06_RS05595	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J06_RS05605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J06_RS05610	COG3935	DnaD domain protein
I6J06_RS05615	COG0017	Asparaginyl-tRNA synthetase
I6J06_RS05620	COG1199	ATP-dependent helicase activity
I6J06_RS05620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J06_RS05630	COG0617	tRNA 3'-terminal CCA addition
I6J06_RS05635	COG0438	transferase activity, transferring glycosyl groups
I6J06_RS05640	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J06_RS05645	COG2738	Putative neutral zinc metallopeptidase
I6J06_RS05650	COG4347	Protein of unknown function (DUF1405)
I6J06_RS05655	COG5582	Belongs to the UPF0302 family
I6J06_RS05665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J06_RS05670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J06_RS05675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J06_RS05680	COG0105	UTP biosynthetic process
I6J06_RS05685	COG0142	geranyltranstransferase activity
I6J06_RS05690	COG2226	methyltransferase
I6J06_RS05705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J06_RS05710	COG1160	GTP binding
I6J06_RS05715	COG0539	negative regulation of cytoplasmic translation
I6J06_RS05720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J06_RS05730	COG0492	ferredoxin-NADP+ reductase activity
I6J06_RS05735	COG1388	LysM domain
I6J06_RS05735	COG1388	LysM domain
I6J06_RS05740	COG0514	ATP-dependent DNA helicase (RecQ)
I6J06_RS05750	COG1141	Ferredoxin
I6J06_RS05765	COG0745	RESPONSE REGULATOR receiver
I6J06_RS05770	COG1187	pseudouridine synthase activity
I6J06_RS05775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J06_RS05780	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J06_RS05790	COG4974	Belongs to the 'phage' integrase family
I6J06_RS05795	COG0735	belongs to the Fur family
I6J06_RS05800	COG0494	nUDIX hydrolase
I6J06_RS05805	COG0667	Aldo Keto reductase
I6J06_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS05815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J06_RS05820	COG1234	tRNA 3'-trailer cleavage
I6J06_RS05825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J06_RS05835	COG0366	Alpha amylase catalytic
I6J06_RS05850	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J06_RS05860	COG4129	membrane
I6J06_RS05870	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J06_RS05875	COG0022	dehydrogenase e1 component
I6J06_RS05880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J06_RS05885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J06_RS05895	COG0280	phosphate acetyltransferase
I6J06_RS05900	COG0497	DNA recombination
I6J06_RS05905	COG1438	arginine binding
I6J06_RS05915	COG1722	exodeoxyribonuclease VII activity
I6J06_RS05920	COG1570	exodeoxyribonuclease VII activity
I6J06_RS05925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J06_RS05930	COG1302	Protein conserved in bacteria
I6J06_RS05935	COG0439	Biotin carboxylase
I6J06_RS05940	COG0511	ligase activity, forming carbon-carbon bonds
I6J06_RS05945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J06_RS05950	COG0006	proline dipeptidase activity
I6J06_RS05965	COG0095	Lipoate-protein ligase
I6J06_RS05970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J06_RS05975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J06_RS05980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J06_RS05985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J06_RS05990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J06_RS06005	COG4537	Required for transformation and DNA binding
I6J06_RS06015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J06_RS06020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J06_RS06025	COG0011	TIGRFAM Protein of
I6J06_RS06030	COG1940	carbohydrate kinase activity
I6J06_RS06035	COG4483	Protein conserved in bacteria
I6J06_RS06045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J06_RS06050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J06_RS06055	COG0768	penicillin binding
I6J06_RS06060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J06_RS06075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J06_RS06080	COG1121	(ABC) transporter
I6J06_RS06085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J06_RS06090	COG0513	Belongs to the DEAD box helicase family
I6J06_RS06095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J06_RS06100	COG2384	SAM-dependent methyltransferase
I6J06_RS06105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J06_RS06115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J06_RS06120	COG0517	IMP dehydrogenase activity
I6J06_RS06125	COG0423	glycine-tRNA ligase activity
I6J06_RS06130	COG1381	Involved in DNA repair and RecF pathway recombination
I6J06_RS06135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J06_RS06145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J06_RS06150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J06_RS06155	COG1702	phosphate starvation-inducible protein PhoH
I6J06_RS06165	COG4864	UPF0365 protein
I6J06_RS06175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J06_RS06180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J06_RS06185	COG2264	protein methyltransferase activity
I6J06_RS06190	COG0484	heat shock protein binding
I6J06_RS06195	COG0443	Heat shock 70 kDa protein
I6J06_RS06200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J06_RS06205	COG1420	regulation of RNA biosynthetic process
I6J06_RS06210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J06_RS06215	COG0481	GTPase activity
I6J06_RS06220	COG0268	Binds directly to 16S ribosomal RNA
I6J06_RS06225	COG1466	dna polymerase III delta subunit
I6J06_RS06230	COG2333	competence protein COMEC
I6J06_RS06230	COG0658	competence protein
I6J06_RS06235	COG2131	deaminase
I6J06_RS06240	COG1555	photosystem II stabilization
I6J06_RS06240	COG1596	polysaccharide export
I6J06_RS06245	COG2226	methyltransferase
I6J06_RS06250	COG0799	negative regulation of ribosome biogenesis
I6J06_RS06255	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J06_RS06260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J06_RS06265	COG1534	Rna-binding protein
I6J06_RS06270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J06_RS06275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J06_RS06280	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J06_RS06285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J06_RS06290	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J06_RS06295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J06_RS06300	COG0439	Biotin carboxylase
I6J06_RS06310	COG1984	allophanate hydrolase subunit 2
I6J06_RS06315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J06_RS06320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J06_RS06325	COG0572	uridine kinase
I6J06_RS06330	COG0826	peptidase U32
I6J06_RS06335	COG0826	peptidase U32
I6J06_RS06340	COG4122	O-methyltransferase activity
I6J06_RS06345	COG3906	Belongs to the UPF0473 family
I6J06_RS06350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J06_RS06355	COG4472	Bacterial protein of unknown function (DUF965)
I6J06_RS06360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J06_RS06365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J06_RS06375	COG0482	sulfurtransferase activity
I6J06_RS06380	COG1104	cysteine desulfurase activity
I6J06_RS06385	COG0488	(ABC) transporter
I6J06_RS06390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS06400	COG3237	CsbD-like
I6J06_RS06405	COG1959	2 iron, 2 sulfur cluster binding
I6J06_RS06410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J06_RS06415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J06_RS06425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J06_RS06430	COG0124	histidyl-tRNA synthetase
I6J06_RS06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J06_RS06440	COG1490	D-aminoacyl-tRNA deacylase activity
I6J06_RS06445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J06_RS06455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J06_RS06455	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J06_RS06460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J06_RS06460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J06_RS06465	COG1862	Preprotein translocase
I6J06_RS06470	COG0343	queuine tRNA-ribosyltransferase activity
I6J06_RS06475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J06_RS06480	COG2255	four-way junction helicase activity
I6J06_RS06485	COG0632	four-way junction helicase activity
I6J06_RS06490	COG4492	Belongs to the UPF0735 family
I6J06_RS06495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J06_RS06500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J06_RS06505	COG2868	ribosomal protein
I6J06_RS06545	COG0656	L-ascorbic acid biosynthetic process
I6J06_RS06560	COG2003	Belongs to the UPF0758 family
I6J06_RS06575	COG0285	dihydrofolate synthase activity
I6J06_RS06580	COG0525	valine-tRNA ligase activity
I6J06_RS06585	COG2818	Glycosylase
I6J06_RS06595	COG3180	Ammonia monooxygenase
I6J06_RS06600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J06_RS06605	COG0113	porphobilinogen synthase activity
I6J06_RS06610	COG1587	Uroporphyrinogen-III synthase
I6J06_RS06615	COG0181	hydroxymethylbilane synthase activity
I6J06_RS06620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J06_RS06625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J06_RS06630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J06_RS06635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J06_RS06640	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J06_RS06650	COG4112	unkown
I6J06_RS06655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J06_RS06660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J06_RS06665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J06_RS06670	COG0833	amino acid
I6J06_RS06675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J06_RS06680	COG1484	DNA-dependent DNA replication
I6J06_RS06690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J06_RS06695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J06_RS06700	COG0237	dephospho-CoA kinase activity
I6J06_RS06705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J06_RS06710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J06_RS06710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J06_RS06715	COG5002	protein histidine kinase activity
I6J06_RS06720	COG0745	RESPONSE REGULATOR receiver
I6J06_RS06725	COG0538	isocitrate dehydrogenase activity
I6J06_RS06730	COG0372	Belongs to the citrate synthase family
I6J06_RS06735	COG1113	amino acid transport
I6J06_RS06740	COG0469	pyruvate kinase activity
I6J06_RS06745	COG0205	6-phosphofructokinase activity
I6J06_RS06750	COG0825	malonyl-CoA metabolic process
I6J06_RS06755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J06_RS06760	COG0281	malic enzyme
I6J06_RS06765	COG0587	DNA-directed DNA polymerase activity
I6J06_RS06770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J06_RS06775	COG4109	DRTGG domain
I6J06_RS06785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J06_RS06790	COG0006	proline dipeptidase activity
I6J06_RS06795	COG3142	Participates in the control of copper homeostasis
I6J06_RS06800	COG0686	Belongs to the AlaDH PNT family
I6J06_RS06805	COG0589	response to stress
I6J06_RS06815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J06_RS06820	COG0827	DNA restriction-modification system
I6J06_RS06825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J06_RS06830	COG1714	RDD family
I6J06_RS06835	COG0616	signal peptide processing
I6J06_RS06845	COG0301	tRNA thio-modification
I6J06_RS06850	COG1104	cysteine desulfurase activity
I6J06_RS06855	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6J06_RS06860	COG1956	GAF domain-containing protein
I6J06_RS06865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J06_RS06875	COG0584	glycerophosphoryl diester phosphodiesterase
I6J06_RS06880	COG1764	response to oxidative stress
I6J06_RS06885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J06_RS06890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J06_RS06900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS06900	COG1263	PTS System
I6J06_RS06905	COG0204	Acyl-transferase
I6J06_RS06910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J06_RS06915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J06_RS06930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J06_RS06935	COG0454	-acetyltransferase
I6J06_RS06940	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6J06_RS06945	COG1609	Transcriptional regulator
I6J06_RS06950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J06_RS06950	COG1605	Chorismate mutase
I6J06_RS06960	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6J06_RS06965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J06_RS06970	COG1674	ftsk spoiiie
I6J06_RS06975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J06_RS06980	COG4848	Belongs to the UPF0354 family
I6J06_RS06985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J06_RS06990	COG1363	Peptidase, m42
I6J06_RS06995	COG5584	Small secreted protein
I6J06_RS07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J06_RS07005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J06_RS07010	COG0510	thiamine kinase activity
I6J06_RS07020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J06_RS07030	COG1187	pseudouridine synthase activity
I6J06_RS07035	COG2244	polysaccharide biosynthetic process
I6J06_RS07040	COG2081	HI0933 family
I6J06_RS07050	COG0495	leucyl-tRNA aminoacylation
I6J06_RS07055	COG2814	Major facilitator Superfamily
I6J06_RS07060	COG1242	4 iron, 4 sulfur cluster binding
I6J06_RS07065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J06_RS07075	COG0039	L-malate dehydrogenase activity
I6J06_RS07080	COG2267	carboxylic ester hydrolase activity
I6J06_RS07085	COG0506	proline dehydrogenase activity
I6J06_RS07090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J06_RS07095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J06_RS07095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J06_RS07100	COG0307	riboflavin synthase, alpha
I6J06_RS07105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J06_RS07105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J06_RS07120	COG4193	domain, Protein
I6J06_RS07120	COG3266	domain, Protein
I6J06_RS07120	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6J06_RS07150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J06_RS07160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J06_RS07165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J06_RS07170	COG0656	L-ascorbic acid biosynthetic process
I6J06_RS07180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J06_RS07185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J06_RS07190	COG1506	peptidase
I6J06_RS07200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J06_RS07230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J06_RS07275	COG3545	Serine hydrolase
I6J06_RS07280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J06_RS07285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J06_RS07290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J06_RS07300	COG4473	ABC transporter
I6J06_RS07305	COG1131	(ABC) transporter
I6J06_RS07310	COG0537	adenosine 5'-monophosphoramidase activity
I6J06_RS07325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J06_RS07330	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6J06_RS07335	COG4717	serine-type aminopeptidase activity
I6J06_RS07340	COG0420	3'-5' exonuclease activity
I6J06_RS07345	COG3679	Belongs to the UPF0342 family
I6J06_RS07350	COG4399	Belongs to the UPF0754 family
I6J06_RS07360	COG0788	formyltetrahydrofolate deformylase activity
I6J06_RS07375	COG1301	dicarboxylic acid transport
I6J06_RS07380	COG2197	response regulator
I6J06_RS07385	COG2203	Gaf domain
I6J06_RS07385	COG4585	Histidine kinase
I6J06_RS07390	COG0564	pseudouridine synthase activity
I6J06_RS07395	COG0114	fumarate hydratase activity
I6J06_RS07410	COG0363	glucosamine-6-phosphate deaminase activity
I6J06_RS07420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J06_RS07425	COG1126	abc transporter atp-binding protein
I6J06_RS07430	COG0765	amino acid transport
I6J06_RS07595	COG0735	belongs to the Fur family
I6J06_RS07600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J06_RS07605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J06_RS07610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J06_RS07615	COG4129	membrane
I6J06_RS07625	COG3557	Belongs to the UPF0374 family
I6J06_RS07630	COG1194	a g-specific adenine glycosylase
I6J06_RS07635	COG1988	membrane-bound metal-dependent
I6J06_RS07655	COG2137	regulation of response to DNA damage stimulus
I6J06_RS07660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J06_RS07665	COG0693	protein deglycase activity
I6J06_RS07675	COG1607	acyl-coa hydrolase
I6J06_RS07680	COG2309	aminopeptidase activity
I6J06_RS07685	COG4840	Belongs to the UPF0435 family
I6J06_RS07690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J06_RS07700	COG1295	ribonuclease BN
I6J06_RS07705	COG2197	response regulator
I6J06_RS07710	COG4585	Histidine kinase
I6J06_RS07725	COG0024	Methionine aminopeptidase
I6J06_RS07730	COG4129	membrane
I6J06_RS07745	COG1528	Iron-storage protein
I6J06_RS07755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J06_RS07765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J06_RS07770	COG1597	lipid kinase activity
I6J06_RS07775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J06_RS07780	COG0154	amidase activity
I6J06_RS07785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J06_RS07790	COG4851	CamS sex pheromone cAM373 precursor
I6J06_RS07795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J06_RS07800	COG0210	DNA helicase
I6J06_RS07805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6J06_RS07815	COG4496	protein, YerC YecD
I6J06_RS07820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J06_RS07830	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6J06_RS07835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J06_RS07840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J06_RS07850	COG0077	Prephenate dehydratase
I6J06_RS07855	COG0471	metal ion transport
I6J06_RS07865	COG1335	isochorismatase
I6J06_RS07870	COG1227	inorganic diphosphatase activity
I6J06_RS07875	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS07880	COG2706	6-phosphogluconolactonase activity
I6J06_RS07935	COG1131	(ABC) transporter
I6J06_RS07950	COG1725	Transcriptional regulator
I6J06_RS07975	COG0459	protein refolding
I6J06_RS07980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J06_RS08005	COG4512	PFAM Accessory gene regulator B
I6J06_RS08015	COG3290	protein histidine kinase activity
I6J06_RS08020	COG3279	Response regulator of the LytR AlgR family
I6J06_RS08030	COG1621	beta-fructofuranosidase activity
I6J06_RS08035	COG1609	Transcriptional regulator
I6J06_RS08040	COG0425	Belongs to the sulfur carrier protein TusA family
I6J06_RS08045	COG2391	methyltransferase activity
I6J06_RS08050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J06_RS08055	COG0488	(ABC) transporter
I6J06_RS08065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J06_RS08070	COG0456	acetyltransferase
I6J06_RS08075	COG1214	PFAM Peptidase M22, glycoprotease
I6J06_RS08080	COG0802	atpase or kinase
I6J06_RS08085	COG0129	dihydroxy-acid dehydratase activity
I6J06_RS08090	COG0028	Belongs to the TPP enzyme family
I6J06_RS08095	COG0440	acetolactate synthase activity
I6J06_RS08100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J06_RS08105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J06_RS08110	COG0473	3-isopropylmalate dehydrogenase activity
I6J06_RS08115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J06_RS08120	COG0066	3-isopropylmalate dehydratase activity
I6J06_RS08125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J06_RS08155	COG3091	SprT-like family
I6J06_RS08160	COG2183	response to ionizing radiation
I6J06_RS08165	COG1191	sigma factor activity
I6J06_RS08180	COG2208	phosphoserine phosphatase activity
I6J06_RS08185	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J06_RS08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J06_RS08200	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J06_RS08210	COG3428	Bacterial PH domain
I6J06_RS08220	COG0513	Belongs to the DEAD box helicase family
I6J06_RS08225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J06_RS08230	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J06_RS08235	COG0772	Belongs to the SEDS family
I6J06_RS08250	COG1937	Protein conserved in bacteria
I6J06_RS08260	COG1418	mRNA catabolic process
I6J06_RS08265	COG0706	membrane insertase activity
I6J06_RS08270	COG0352	thiamine-phosphate diphosphorylase activity
I6J06_RS08275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6J06_RS08285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J06_RS08290	COG1388	LysM domain
I6J06_RS08295	COG0629	single-stranded DNA binding
I6J06_RS08305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J06_RS08310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J06_RS08320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J06_RS08325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J06_RS08330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J06_RS08335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J06_RS08340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J06_RS08345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J06_RS08350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J06_RS08355	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J06_RS08365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J06_RS08370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J06_RS08375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J06_RS08380	COG4475	Protein of unknown function (DUF436)
I6J06_RS08385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J06_RS08390	COG0009	L-threonylcarbamoyladenylate synthase
I6J06_RS08395	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J06_RS08400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J06_RS08405	COG1435	thymidine kinase activity
I6J06_RS08410	COG0254	rRNA binding
I6J06_RS08415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J06_RS08420	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS08430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J06_RS08435	COG0191	fructose-bisphosphate aldolase activity
I6J06_RS08440	COG0504	CTP synthase activity
I6J06_RS08445	COG3343	RNA polymerase activity
I6J06_RS08450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J06_RS08460	COG5146	pantothenate kinase activity
I6J06_RS08480	COG1854	S-ribosylhomocysteine lyase activity
I6J06_RS08490	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J06_RS08495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6J06_RS08500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J06_RS08505	COG0813	purine-nucleoside phosphorylase activity
I6J06_RS08510	COG0783	Belongs to the Dps family
I6J06_RS08515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J06_RS08530	COG2855	membrane
I6J06_RS08540	COG1482	cell wall glycoprotein biosynthetic process
I6J06_RS08545	COG2186	Transcriptional regulator
I6J06_RS08550	COG0702	epimerase
I6J06_RS08555	COG0640	Transcriptional regulator
I6J06_RS08580	COG1119	ATPase activity
I6J06_RS08605	COG3711	transcriptional antiterminator
I6J06_RS08615	COG0246	Mannitol dehydrogenase
I6J06_RS08620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J06_RS08630	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J06_RS08685	COG0489	protein tyrosine kinase activity
I6J06_RS08700	COG1272	protein, Hemolysin III
I6J06_RS08705	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6J06_RS08710	COG1988	membrane-bound metal-dependent
I6J06_RS08720	COG2329	Antibiotic biosynthesis monooxygenase
I6J06_RS08725	COG3314	Sporulation integral membrane protein YlbJ
I6J06_RS08730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS08735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS08740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J06_RS08745	COG3457	Alanine racemase
I6J06_RS08750	COG4264	IucA IucC family
I6J06_RS08755	COG4264	IucA IucC family
I6J06_RS08760	COG1302	Protein conserved in bacteria
I6J06_RS08775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J06_RS08780	COG0604	alcohol dehydrogenase
I6J06_RS08785	COG2130	NADP-dependent
I6J06_RS08790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS08805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J06_RS08810	COG0101	tRNA pseudouridine synthase activity
I6J06_RS08820	COG1122	ATPase activity
I6J06_RS08825	COG1122	ATPase activity
I6J06_RS08830	COG0203	ribosomal protein L17
I6J06_RS08835	COG0202	RNA polymerase activity
I6J06_RS08845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J06_RS08850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J06_RS08865	COG0201	protein transport
I6J06_RS08870	COG0200	Binds to the 23S rRNA
I6J06_RS08875	COG1841	ribosomal large subunit assembly
I6J06_RS08880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J06_RS08885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J06_RS08890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J06_RS08895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J06_RS08900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J06_RS08905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J06_RS08910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J06_RS08915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J06_RS08920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J06_RS08925	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J06_RS08930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J06_RS08935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J06_RS08940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J06_RS08945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J06_RS08950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J06_RS08955	COG0089	rRNA binding
I6J06_RS08960	COG0088	Forms part of the polypeptide exit tunnel
I6J06_RS08965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J06_RS08970	COG0051	transcription antitermination factor activity, RNA binding
I6J06_RS08980	COG2252	PERMEase
I6J06_RS08985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J06_RS08985	COG0551	DNA topoisomerase type I activity
I6J06_RS08995	COG4975	Glucose uptake
I6J06_RS09020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J06_RS09025	COG2348	transferase activity, transferring amino-acyl groups
I6J06_RS09040	COG2814	Major facilitator Superfamily
I6J06_RS09050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J06_RS09055	COG0746	molybdenum cofactor guanylyltransferase activity
I6J06_RS09070	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J06_RS09080	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J06_RS09085	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J06_RS09090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J06_RS09095	COG1510	regulation of RNA biosynthetic process
I6J06_RS09100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J06_RS09105	COG4149	molybdate abc transporter
I6J06_RS09110	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J06_RS09115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6J06_RS09120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J06_RS09125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J06_RS09130	COG1609	Transcriptional regulator
I6J06_RS09135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J06_RS09145	COG1268	BioY protein
I6J06_RS09150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS09155	COG1960	acyl-CoA dehydrogenase activity
I6J06_RS09160	COG1126	abc transporter atp-binding protein
I6J06_RS09165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J06_RS09170	COG0765	amino acid transport
I6J06_RS09175	COG0765	amino acid transport
I6J06_RS09200	COG3942	CHAP domain
I6J06_RS09210	COG1757	Na H antiporter
I6J06_RS09230	COG2076	Multidrug Resistance protein
I6J06_RS09235	COG2076	Multidrug Resistance protein
I6J06_RS09240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J06_RS09265	COG3383	formate dehydrogenase (NAD+) activity
I6J06_RS09270	COG1316	TRANSCRIPTIONal
I6J06_RS09275	COG0483	inositol monophosphate 1-phosphatase activity
I6J06_RS09295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J06_RS09300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS09300	COG1263	PTS System
I6J06_RS09310	COG1785	Belongs to the alkaline phosphatase family
I6J06_RS09315	COG1113	amino acid transport
I6J06_RS09335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J06_RS09340	COG0385	Bile acid
I6J06_RS09350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS09350	COG1263	PTS System
I6J06_RS09370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J06_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS09380	COG1473	amidohydrolase
I6J06_RS09385	COG0659	secondary active sulfate transmembrane transporter activity
I6J06_RS09390	COG1228	amidohydrolase
I6J06_RS09395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J06_RS09400	COG3314	Sporulation integral membrane protein YlbJ
I6J06_RS09405	COG0583	DNA-binding transcription factor activity
I6J06_RS09410	COG0010	Belongs to the arginase family
I6J06_RS09415	COG1266	CAAX protease self-immunity
I6J06_RS09420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J06_RS09425	COG2258	MOSC domain
I6J06_RS09435	COG1668	transmembrane transport
I6J06_RS09440	COG4152	abc transporter atp-binding protein
I6J06_RS09450	COG2094	Belongs to the DNA glycosylase MPG family
I6J06_RS09455	COG1757	Na H antiporter
I6J06_RS09460	COG0786	glutamate:sodium symporter activity
I6J06_RS09465	COG1304	FMN binding
I6J06_RS09495	COG2814	Major facilitator Superfamily
I6J06_RS09500	COG1566	PFAM secretion protein HlyD family protein
I6J06_RS09510	COG2814	Major facilitator Superfamily
I6J06_RS09515	COG4640	response to antibiotic
I6J06_RS09530	COG1136	(ABC) transporter
I6J06_RS09535	COG0577	efflux transmembrane transporter activity
I6J06_RS09540	COG0745	RESPONSE REGULATOR receiver
I6J06_RS09545	COG5002	protein histidine kinase activity
I6J06_RS09545	COG3850	Histidine kinase
I6J06_RS09555	COG0438	transferase activity, transferring glycosyl groups
I6J06_RS09560	COG1620	l-lactate permease
I6J06_RS09565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J06_RS09580	COG0604	alcohol dehydrogenase
I6J06_RS09585	COG2814	Major facilitator Superfamily
I6J06_RS09595	COG0492	ferredoxin-NADP+ reductase activity
I6J06_RS09605	COG4549	nuclear export factor GLE1
I6J06_RS09615	COG0698	ribose 5-phosphate isomerase
I6J06_RS09625	COG2376	Dihydroxyacetone kinase
I6J06_RS09630	COG1063	alcohol dehydrogenase
I6J06_RS09635	COG1349	DNA-binding transcription factor activity
I6J06_RS09640	COG1288	antiporter activity
I6J06_RS09645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS09655	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J06_RS09675	COG1263	PTS System
I6J06_RS09675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS09700	COG1846	Transcriptional regulator
I6J06_RS09710	COG2223	nitrite transmembrane transporter activity
I6J06_RS09715	COG2197	response regulator
I6J06_RS09720	COG4585	Histidine kinase
I6J06_RS09730	COG2181	nitrate reductase activity
I6J06_RS09735	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J06_RS09740	COG1140	nitrate reductase beta subunit
I6J06_RS09745	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J06_RS09750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J06_RS09750	COG1648	precorrin-2 dehydrogenase activity
I6J06_RS09755	COG2146	nitrite reductase [NAD(P)H] activity
I6J06_RS09775	COG0454	-acetyltransferase
I6J06_RS09780	COG2116	formate transmembrane transporter activity
I6J06_RS09785	COG1959	2 iron, 2 sulfur cluster binding
I6J06_RS09815	COG2353	YceI-like domain
I6J06_RS09820	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J06_RS09820	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J06_RS09825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J06_RS09840	COG2814	Major facilitator Superfamily
I6J06_RS09850	COG1131	(ABC) transporter
I6J06_RS09855	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6J06_RS09860	COG0588	phosphoglycerate mutase activity
I6J06_RS09865	COG1388	LysM domain
I6J06_RS09870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J06_RS09880	COG2814	Major facilitator Superfamily
I6J06_RS09905	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J06_RS09925	COG4187	Peptidase family M20/M25/M40
I6J06_RS09935	COG1116	anion transmembrane transporter activity
I6J06_RS09945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J06_RS09950	COG1960	acyl-CoA dehydrogenase activity
I6J06_RS09960	COG1174	glycine betaine transport
I6J06_RS09970	COG1174	glycine betaine transport
I6J06_RS09985	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J06_RS09990	COG3246	L-lysine catabolic process to acetate
I6J06_RS10000	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6J06_RS10005	COG0531	amino acid
I6J06_RS10010	COG2814	Major facilitator Superfamily
I6J06_RS10015	COG0390	transport system, permease component
I6J06_RS10020	COG4619	ABC transporter
I6J06_RS10030	COG0069	glutamate synthase activity
I6J06_RS10040	COG1363	Peptidase, m42
I6J06_RS10045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6J06_RS10050	COG0248	Ppx GppA phosphatase
I6J06_RS10055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J06_RS10065	COG3048	D-serine ammonia-lyase activity
I6J06_RS10070	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6J06_RS10075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J06_RS10080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J06_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J06_RS10090	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J06_RS10095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J06_RS10100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J06_RS10105	COG0107	imidazoleglycerol-phosphate synthase activity
I6J06_RS10115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS10130	COG4221	oxidoreductase activity
I6J06_RS10155	COG3250	beta-galactosidase activity
I6J06_RS10160	COG2211	Major facilitator Superfamily
I6J06_RS10170	COG3949	Membrane
I6J06_RS10175	COG2610	gluconate transmembrane transporter activity
I6J06_RS10185	COG1802	Transcriptional regulator
I6J06_RS10190	COG2357	RelA SpoT domain protein
I6J06_RS10195	COG4876	unkown
I6J06_RS10210	COG1289	transmembrane transporter activity
I6J06_RS10215	COG3527	Alpha-acetolactate decarboxylase
I6J06_RS10225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J06_RS10230	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J06_RS10240	COG3949	Membrane
I6J06_RS10245	COG0400	carboxylic ester hydrolase activity
I6J06_RS10250	COG0346	lactoylglutathione lyase activity
I6J06_RS10255	COG0346	lactoylglutathione lyase activity
I6J06_RS10260	COG1846	Transcriptional regulator
I6J06_RS10265	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS10270	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J06_RS10280	COG1132	(ABC) transporter
I6J06_RS10285	COG1132	(ABC) transporter
I6J06_RS10295	COG2514	catechol 2,3-dioxygenase activity
I6J06_RS10300	COG0778	Nitroreductase
I6J06_RS10305	COG0561	phosphatase activity
I6J06_RS10310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J06_RS10315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J06_RS10325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J06_RS10330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J06_RS10335	COG3764	Sortase (surface protein transpeptidase)
I6J06_RS10360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J06_RS10365	COG1063	alcohol dehydrogenase
I6J06_RS10370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J06_RS10385	COG2843	Capsule synthesis protein
I6J06_RS10395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J06_RS10410	COG0657	acetylesterase activity
I6J06_RS10430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J06_RS10445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J06_RS10445	COG2190	(PTS) system
I6J06_RS10445	COG1263	PTS System
I6J06_RS10450	COG1288	antiporter activity
I6J06_RS10465	COG0028	Belongs to the TPP enzyme family
I6J06_RS10475	COG1380	Effector of murein hydrolase LrgA
I6J06_RS10480	COG0583	DNA-binding transcription factor activity
I6J06_RS10485	COG1757	Na H antiporter
I6J06_RS10490	COG3386	PFAM SMP-30 Gluconolaconase
I6J06_RS10505	COG3425	synthase
I6J06_RS10510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J06_RS10515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J06_RS10530	COG2819	hydrolase of the alpha beta superfamily
I6J06_RS10540	COG1473	amidohydrolase
I6J06_RS10555	COG2409	Drug exporters of the RND superfamily
I6J06_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS10570	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I6J06_RS10585	COG4336	lyase activity
I6J06_RS10605	COG0471	metal ion transport
I6J06_RS10630	COG1136	(ABC) transporter
I6J06_RS10630	COG0577	efflux transmembrane transporter activity
I6J06_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS10640	COG0577	efflux transmembrane transporter activity
I6J06_RS10645	COG1136	(ABC) transporter
I6J06_RS10650	COG0659	secondary active sulfate transmembrane transporter activity
I6J06_RS10655	COG2217	Heavy metal translocating P-type atpase
I6J06_RS10660	COG2608	mercury ion transmembrane transporter activity
I6J06_RS10670	COG0436	Aminotransferase
I6J06_RS10675	COG1388	LysM domain
I6J06_RS10690	COG3189	MarR family transcriptional regulator
I6J06_RS10695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J06_RS10730	COG3001	Fructosamine kinase
I6J06_RS10735	COG0167	dihydroorotate dehydrogenase activity
I6J06_RS10745	COG0561	phosphatase activity
I6J06_RS10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS10790	COG0747	negative chemotaxis
I6J06_RS10795	COG4413	Urea transporter
I6J06_RS10800	COG0831	urea catabolic process
I6J06_RS10805	COG0832	Belongs to the urease beta subunit family
I6J06_RS10810	COG0804	urea catabolic process
I6J06_RS10815	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6J06_RS10820	COG0830	nickel cation binding
I6J06_RS10825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J06_RS10830	COG0829	nickel cation binding
I6J06_RS10840	COG3949	Membrane
I6J06_RS10850	COG0626	cystathionine gamma-synthase activity
I6J06_RS10855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J06_RS10875	COG1940	carbohydrate kinase activity
I6J06_RS10880	COG1482	cell wall glycoprotein biosynthetic process
I6J06_RS10885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J06_RS10885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J06_RS10885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS10890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS10890	COG3711	transcriptional antiterminator
I6J06_RS10895	COG0039	L-malate dehydrogenase activity
I6J06_RS10900	COG1464	Belongs to the NlpA lipoprotein family
I6J06_RS10905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J06_RS10920	COG3181	Tripartite tricarboxylate transporter family receptor
I6J06_RS10940	COG0438	transferase activity, transferring glycosyl groups
I6J06_RS10950	COG3037	sugar-specific permease SgaT UlaA
I6J06_RS10960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS10970	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J06_RS10985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J06_RS10990	COG1940	carbohydrate kinase activity
I6J06_RS10990	COG1846	Transcriptional regulator
I6J06_RS11005	COG2348	transferase activity, transferring amino-acyl groups
I6J06_RS11010	COG0363	glucosamine-6-phosphate deaminase activity
I6J06_RS11025	COG2814	Major facilitator Superfamily
I6J06_RS11030	COG1620	l-lactate permease
I6J06_RS11040	COG0431	NADPH-dependent FMN reductase
I6J06_RS11050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J06_RS11055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J06_RS11060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J06_RS11065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J06_RS11070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J06_RS11075	COG2610	gluconate transmembrane transporter activity
I6J06_RS11080	COG1131	(ABC) transporter
I6J06_RS11105	COG1957	nucleoside hydrolase
I6J06_RS11110	COG2843	Capsule synthesis protein
I6J06_RS11120	COG0778	Nitroreductase
I6J06_RS11130	COG0463	Glycosyl transferase, family 2
I6J06_RS11130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J06_RS11145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6J06_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS11155	COG1510	regulation of RNA biosynthetic process
I6J06_RS11160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J06_RS11170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J06_RS11190	COG0531	amino acid
I6J06_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS11200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J06_RS11205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J06_RS11215	COG2807	transmembrane transport
I6J06_RS11220	COG1476	TRANSCRIPTIONal
I6J06_RS11245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J06_RS11250	COG0574	Belongs to the PEP-utilizing enzyme family
I6J06_RS11250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J06_RS11255	COG3835	regulator
I6J06_RS11260	COG1929	Belongs to the glycerate kinase type-1 family
I6J06_RS11270	COG3875	lactate racemase activity
I6J06_RS11275	COG1606	tRNA processing
I6J06_RS11280	COG1691	(AIR) carboxylase
I6J06_RS11285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6J06_RS11290	COG0673	inositol 2-dehydrogenase activity
I6J06_RS11330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS11340	COG3961	Belongs to the TPP enzyme family
I6J06_RS11350	COG1846	Transcriptional regulator
I6J06_RS11375	COG0584	glycerophosphoryl diester phosphodiesterase
I6J06_RS11385	COG2814	Major facilitator Superfamily
I6J06_RS11395	COG0477	Major facilitator Superfamily
I6J06_RS11415	COG0579	oxidoreductase
I6J06_RS11420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J06_RS11425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J06_RS11465	COG1136	(ABC) transporter
I6J06_RS11470	COG2610	gluconate transmembrane transporter activity
I6J06_RS11480	COG2084	Dehydrogenase
I6J06_RS11485	COG2188	Transcriptional regulator
I6J06_RS11490	COG0346	lactoylglutathione lyase activity
I6J06_RS11500	COG0431	NADPH-dependent FMN reductase
I6J06_RS11505	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6J06_RS11510	COG0602	queuosine metabolic process
I6J06_RS11515	COG1328	CTP reductase activity
I6J06_RS11520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J06_RS11525	COG2022	thiamine diphosphate biosynthetic process
I6J06_RS11535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J06_RS11545	COG1070	Carbohydrate kinase
I6J06_RS11565	COG1511	domain protein
I6J06_RS11580	COG1131	(ABC) transporter
I6J06_RS11590	COG1846	Transcriptional regulator
I6J06_RS11590	COG1940	carbohydrate kinase activity
I6J06_RS11595	COG2115	Belongs to the xylose isomerase family
I6J06_RS11600	COG1070	Carbohydrate kinase
I6J06_RS11605	COG2814	Major facilitator Superfamily
I6J06_RS11605	COG0477	Major facilitator Superfamily
I6J06_RS11615	COG1131	(ABC) transporter
I6J06_RS11630	COG2160	L-arabinose isomerase activity
I6J06_RS11635	COG0235	Class ii aldolase
I6J06_RS11645	COG1609	Transcriptional regulator
I6J06_RS11650	COG1609	Transcriptional regulator
I6J06_RS11655	COG4975	Glucose uptake
I6J06_RS11680	COG1054	Belongs to the UPF0176 family
I6J06_RS11695	COG1388	LysM domain
I6J06_RS11700	COG0564	pseudouridine synthase activity
I6J06_RS11705	COG1388	LysM domain
I6J06_RS11710	COG2318	DinB family
I6J06_RS11715	COG0471	metal ion transport
I6J06_RS11725	COG1012	belongs to the aldehyde dehydrogenase family
I6J06_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS11740	COG3192	ethanolamine utilization protein
I6J06_RS11765	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J06_RS11770	COG3775	system Galactitol-specific IIC component
I6J06_RS11775	COG1063	alcohol dehydrogenase
I6J06_RS11785	COG1063	alcohol dehydrogenase
I6J06_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS11810	COG2186	Transcriptional regulator
I6J06_RS11815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6J06_RS11815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6J06_RS11825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J06_RS11840	COG1695	Transcriptional regulator
I6J06_RS11845	COG2059	Chromate
I6J06_RS11850	COG1929	Belongs to the glycerate kinase type-1 family
I6J06_RS11860	COG0745	RESPONSE REGULATOR receiver
I6J06_RS11865	COG5002	protein histidine kinase activity
I6J06_RS11865	COG3850	Histidine kinase
I6J06_RS11880	COG0463	Glycosyl transferase, family 2
I6J06_RS11900	COG1475	DNA binding
I6J06_RS11905	COG0019	diaminopimelate decarboxylase activity
I6J06_RS11915	COG4264	IucA IucC family
I6J06_RS11920	COG4264	IucA IucC family
I6J06_RS11925	COG2814	Major facilitator Superfamily
I6J06_RS11930	COG4264	IucA IucC family
I6J06_RS11935	COG2423	ornithine cyclodeaminase activity
I6J06_RS11945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS11950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS11955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J06_RS11970	COG1607	acyl-coa hydrolase
I6J06_RS11975	COG0583	DNA-binding transcription factor activity
I6J06_RS11980	COG3250	beta-galactosidase activity
I6J06_RS11985	COG2211	Major facilitator Superfamily
I6J06_RS11990	COG2207	Transcriptional regulator
I6J06_RS12000	COG1476	TRANSCRIPTIONal
I6J06_RS12010	COG4555	ABC transporter
I6J06_RS12045	COG1942	4-Oxalocrotonate Tautomerase
I6J06_RS12065	COG3759	membrane
I6J06_RS12075	COG2130	NADP-dependent
I6J06_RS12080	COG4145	pantothenate transmembrane transporter activity
I6J06_RS12090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J06_RS12110	COG1215	transferase activity, transferring glycosyl groups
I6J06_RS12115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J06_RS12125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J06_RS12130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J06_RS12160	COG0523	cobalamin synthesis protein
I6J06_RS12165	COG0281	malic enzyme
I6J06_RS12170	COG3493	citrate carrier protein
I6J06_RS12175	COG4565	transcriptional regulatory protein
I6J06_RS12180	COG3290	protein histidine kinase activity
I6J06_RS12185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J06_RS12190	COG1064	alcohol dehydrogenase
I6J06_RS12285	COG4268	DNA restriction-modification system
I6J06_RS12290	COG1401	restriction endodeoxyribonuclease activity
I6J06_RS12300	COG0513	Belongs to the DEAD box helicase family
I6J06_RS12310	COG0202	RNA polymerase activity
I6J06_RS12330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J06_RS12370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J06_RS12375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J06_RS12385	COG4863	YycH protein
I6J06_RS12390	COG5002	protein histidine kinase activity
I6J06_RS12395	COG0745	RESPONSE REGULATOR receiver
I6J06_RS12400	COG0477	Major facilitator Superfamily
I6J06_RS12420	COG1819	glycosyl
I6J06_RS12425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J06_RS12430	COG0305	Participates in initiation and elongation during chromosome replication
I6J06_RS12435	COG0359	binds to the 23S rRNA
I6J06_RS12450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J06_RS12460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J06_RS12465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J06_RS12470	COG2986	histidine ammonia-lyase
I6J06_RS12475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J06_RS12480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J06_RS12485	COG0187	DNA topoisomerase II activity
I6J06_RS12490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J06_RS12495	COG2501	S4 domain
I6J06_RS12500	COG0592	DNA-directed DNA polymerase activity
I6J06_RS12505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J06_RS12515	COG0594	ribonuclease P activity
I6J06_RS12520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J06_RS12525	COG0445	tRNA wobble uridine modification
I6J06_RS12530	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J06_RS12535	COG1475	DNA binding
I6J06_RS12540	COG1966	Carbon starvation protein
I6J06_RS12550	COG2211	Major facilitator Superfamily
I6J06_RS12585	COG0656	L-ascorbic acid biosynthetic process
I6J06_RS12595	COG0531	amino acid
I6J06_RS12600	COG3386	PFAM SMP-30 Gluconolaconase
I6J06_RS12605	COG0640	Transcriptional regulator
I6J06_RS12650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J06_RS12650	COG3711	transcriptional antiterminator
I6J06_RS12665	COG3732	PTS system glucitol sorbitol-specific
I6J06_RS12675	COG0561	phosphatase activity
I6J06_RS12690	COG0450	alkyl hydroperoxide reductase
I6J06_RS12700	COG1063	alcohol dehydrogenase
I6J06_RS12705	COG0667	Aldo Keto reductase
I6J06_RS12750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J06_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
I6J06_RS12780	COG0183	Belongs to the thiolase family
I6J06_RS12790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J06_RS12810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J06_RS12815	COG0646	methionine synthase
I6J06_RS12815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J06_RS12820	COG0626	cystathionine gamma-synthase activity
I6J06_RS12825	COG0626	cystathionine gamma-synthase activity
I6J06_RS12830	COG1475	DNA binding
I6J06_RS12835	COG1228	amidohydrolase
I6J06_RS12840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J06_RS12840	COG1017	nitric oxide dioxygenase activity
I6J06_RS12845	COG0175	sulfate reduction
I6J06_RS12850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J06_RS12855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J06_RS12875	COG0730	response to heat
I6J06_RS12880	COG2046	Belongs to the sulfate adenylyltransferase family
I6J06_RS12885	COG0529	Catalyzes the synthesis of activated sulfate
I6J06_RS12890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J06_RS12900	COG0772	Belongs to the SEDS family
I6J06_RS12925	COG1131	(ABC) transporter
I6J06_RS12940	COG0753	catalase activity
I6J06_RS12955	COG1846	Transcriptional regulator
I6J06_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS12965	COG2030	dehydratase
I6J06_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
I6J06_RS13005	COG1120	ATPase activity
I6J06_RS13010	COG1733	regulation of RNA biosynthetic process
I6J06_RS13015	COG2814	Major facilitator Superfamily
I6J06_RS13020	COG1473	amidohydrolase
I6J06_RS13025	COG2814	Major facilitator Superfamily
I6J06_RS13030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J06_RS13035	COG1388	LysM domain
I6J06_RS13050	COG2314	TM2 domain
I6J06_RS13070	COG1131	(ABC) transporter
I6J06_RS13085	COG3226	Transcriptional regulator
I6J06_RS13095	COG3173	Aminoglycoside phosphotransferase
I6J06_RS13100	COG0477	Major facilitator Superfamily
I6J06_RS13125	COG3682	Transcriptional regulator
I6J06_RS13155	COG1607	acyl-coa hydrolase
I6J06_RS13165	COG1063	alcohol dehydrogenase
I6J06_RS13185	COG0693	protein deglycase activity