locus-tag	class	description
AWC34_RS00010	COG0594	ribonuclease P activity
AWC34_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWC34_RS00020	COG0445	tRNA wobble uridine modification
AWC34_RS00025	COG0357	Ribosomal RNA small subunit methyltransferase G
AWC34_RS00030	COG1475	DNA binding
AWC34_RS00035	COG1966	Carbon starvation protein
AWC34_RS00045	COG2211	Major facilitator Superfamily
AWC34_RS00075	COG0656	L-ascorbic acid biosynthetic process
AWC34_RS00080	COG0531	amino acid
AWC34_RS00085	COG3386	PFAM SMP-30 Gluconolaconase
AWC34_RS00090	COG0640	Transcriptional regulator
AWC34_RS00145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS00145	COG3711	transcriptional antiterminator
AWC34_RS00160	COG3732	PTS system glucitol sorbitol-specific
AWC34_RS00170	COG0561	phosphatase activity
AWC34_RS00185	COG0450	alkyl hydroperoxide reductase
AWC34_RS00195	COG1063	alcohol dehydrogenase
AWC34_RS00225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS00240	COG0318	PFAM AMP-dependent synthetase and ligase
AWC34_RS00255	COG0183	Belongs to the thiolase family
AWC34_RS00265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AWC34_RS00280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWC34_RS00285	COG0646	methionine synthase
AWC34_RS00285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWC34_RS00290	COG0626	cystathionine gamma-synthase activity
AWC34_RS00295	COG0626	cystathionine gamma-synthase activity
AWC34_RS00300	COG1475	DNA binding
AWC34_RS00305	COG1228	amidohydrolase
AWC34_RS00310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AWC34_RS00310	COG1017	nitric oxide dioxygenase activity
AWC34_RS00315	COG0175	sulfate reduction
AWC34_RS00320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AWC34_RS00325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWC34_RS00345	COG0730	response to heat
AWC34_RS00350	COG2046	Belongs to the sulfate adenylyltransferase family
AWC34_RS00355	COG0529	Catalyzes the synthesis of activated sulfate
AWC34_RS00365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AWC34_RS00375	COG0772	Belongs to the SEDS family
AWC34_RS00400	COG1131	(ABC) transporter
AWC34_RS00415	COG0753	catalase activity
AWC34_RS00430	COG1846	Transcriptional regulator
AWC34_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS00440	COG2030	dehydratase
AWC34_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS00480	COG1120	ATPase activity
AWC34_RS00485	COG1733	regulation of RNA biosynthetic process
AWC34_RS00490	COG2814	Major facilitator Superfamily
AWC34_RS00495	COG1473	amidohydrolase
AWC34_RS00500	COG2814	Major facilitator Superfamily
AWC34_RS00505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWC34_RS00510	COG1388	LysM domain
AWC34_RS00525	COG2314	TM2 domain
AWC34_RS00535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWC34_RS00550	COG0300	oxidoreductase activity
AWC34_RS00560	COG2211	Major facilitator Superfamily
AWC34_RS00565	COG1486	melibiose metabolic process
AWC34_RS00570	COG2169	Transcriptional regulator
AWC34_RS00575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWC34_RS00580	COG3002	Belongs to the UPF0753 family
AWC34_RS00585	COG5609	conserved protein (DUF2294)
AWC34_RS00590	COG0668	transmembrane transport
AWC34_RS00595	COG4481	Protein conserved in bacteria
AWC34_RS00600	COG0012	GTP binding
AWC34_RS00610	COG0360	Binds together with S18 to 16S ribosomal RNA
AWC34_RS00620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWC34_RS00645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWC34_RS00650	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWC34_RS00655	COG2723	6-phospho-beta-galactosidase activity
AWC34_RS00660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS00660	COG3711	transcriptional antiterminator
AWC34_RS00665	COG4195	phage-related replication protein
AWC34_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWC34_RS00690	COG2076	Multidrug Resistance protein
AWC34_RS00695	COG2076	Multidrug Resistance protein
AWC34_RS00700	COG1280	lysine exporter protein (LysE YggA)
AWC34_RS00710	COG0588	phosphoglycerate mutase activity
AWC34_RS00725	COG3634	alkyl hydroperoxide reductase activity
AWC34_RS00730	COG0450	alkyl hydroperoxide reductase
AWC34_RS00745	COG3279	Response regulator of the LytR AlgR family
AWC34_RS00750	COG3620	sequence-specific DNA binding
AWC34_RS00755	COG0753	catalase activity
AWC34_RS00765	COG0778	Nitroreductase
AWC34_RS00775	COG1823	symporter activity
AWC34_RS00785	COG5183	chlorophyll binding
AWC34_RS00800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWC34_RS00805	COG2233	PERMEase
AWC34_RS00810	COG0516	GMP reductase activity
AWC34_RS00810	COG0517	IMP dehydrogenase activity
AWC34_RS00815	COG0519	Catalyzes the synthesis of GMP from XMP
AWC34_RS00815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWC34_RS00865	COG2814	Major facilitator Superfamily
AWC34_RS00870	COG0583	DNA-binding transcription factor activity
AWC34_RS00880	COG1595	DNA-templated transcription, initiation
AWC34_RS00890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWC34_RS00900	COG0406	alpha-ribazole phosphatase activity
AWC34_RS00905	COG2807	transmembrane transport
AWC34_RS00910	COG4195	phage-related replication protein
AWC34_RS00925	COG5646	InterPro IPR014922
AWC34_RS00930	COG1114	Component of the transport system for branched-chain amino acids
AWC34_RS00935	COG0733	neurotransmitter:sodium symporter activity
AWC34_RS00940	COG0129	dihydroxy-acid dehydratase activity
AWC34_RS00950	COG3942	CHAP domain
AWC34_RS00950	COG1388	LysM domain
AWC34_RS00965	COG0004	ammonium transporteR
AWC34_RS00980	COG0583	DNA-binding transcription factor activity
AWC34_RS00985	COG0070	glutamate synthase
AWC34_RS00985	COG0069	glutamate synthase activity
AWC34_RS00985	COG0067	glutamate synthase
AWC34_RS00990	COG0493	'glutamate synthase
AWC34_RS01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS01000	COG1263	PTS System
AWC34_RS01005	COG0366	Alpha amylase catalytic
AWC34_RS01010	COG2188	Transcriptional regulator
AWC34_RS01020	COG3153	acetyltransferase
AWC34_RS01025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWC34_RS01030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWC34_RS01035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWC34_RS01070	COG1982	Orn Lys Arg decarboxylase major
AWC34_RS01075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWC34_RS01080	COG3870	Protein conserved in bacteria
AWC34_RS01085	COG0470	DNA polymerase III
AWC34_RS01090	COG1774	PSP1 C-terminal conserved region
AWC34_RS01095	COG4467	Involved in initiation control of chromosome replication
AWC34_RS01100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWC34_RS01105	COG2827	Endonuclease containing a URI domain
AWC34_RS01110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWC34_RS01115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWC34_RS01115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWC34_RS01120	COG0084	hydrolase, TatD family'
AWC34_RS01125	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWC34_RS01130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWC34_RS01135	COG4466	Protein conserved in bacteria
AWC34_RS01140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWC34_RS01145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWC34_RS01150	COG0251	oxidation-reduction process
AWC34_RS01155	COG2088	sporulation resulting in formation of a cellular spore
AWC34_RS01160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWC34_RS01165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWC34_RS01170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWC34_RS01175	COG0193	aminoacyl-tRNA hydrolase activity
AWC34_RS01180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWC34_RS01185	COG2244	polysaccharide biosynthetic process
AWC34_RS01190	COG3956	TIGRFAM MazG family protein
AWC34_RS01195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWC34_RS01205	COG1098	S1 RNA binding domain
AWC34_RS01220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWC34_RS01225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWC34_RS01245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWC34_RS01250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWC34_RS01335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWC34_RS01340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AWC34_RS01345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AWC34_RS01350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWC34_RS01355	COG4463	regulation of RNA biosynthetic process
AWC34_RS01360	COG3880	PFAM UvrB UvrC protein
AWC34_RS01365	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AWC34_RS01370	COG0542	response to heat
AWC34_RS01375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWC34_RS01380	COG4956	integral membrane protein (PIN domain superfamily)
AWC34_RS01385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWC34_RS01390	COG1045	serine acetyltransferase
AWC34_RS01395	COG0215	cysteine-tRNA ligase activity
AWC34_RS01400	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWC34_RS01405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWC34_RS01410	COG3688	RNA-binding protein containing a PIN domain
AWC34_RS01425	COG0250	Participates in transcription elongation, termination and antitermination
AWC34_RS01430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AWC34_RS01435	COG0081	regulation of translation
AWC34_RS01440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWC34_RS01450	COG2813	Specifically methylates the guanine in position
AWC34_RS01455	COG0085	RNA polymerase activity
AWC34_RS01460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWC34_RS01470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWC34_RS01475	COG0049	tRNA binding
AWC34_RS01480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWC34_RS01485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWC34_RS01490	COG1473	amidohydrolase
AWC34_RS01535	COG1086	Polysaccharide biosynthesis protein
AWC34_RS01545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWC34_RS01550	COG0110	maltose O-acetyltransferase activity
AWC34_RS01580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWC34_RS01590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWC34_RS01595	COG1316	TRANSCRIPTIONal
AWC34_RS01600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWC34_RS01600	COG0463	Glycosyl transferase, family 2
AWC34_RS01610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWC34_RS01615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWC34_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS01655	COG0583	DNA-binding transcription factor activity
AWC34_RS01660	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
AWC34_RS01670	COG0800	Aldolase
AWC34_RS01695	COG1904	glucuronate isomerase
AWC34_RS01700	COG1312	Catalyzes the dehydration of D-mannonate
AWC34_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS01710	COG1132	(ABC) transporter
AWC34_RS01715	COG1069	ribulokinase activity
AWC34_RS01720	COG3949	Membrane
AWC34_RS01725	COG1914	H( )-stimulated, divalent metal cation uptake system
AWC34_RS01730	COG0010	Belongs to the arginase family
AWC34_RS01740	COG0833	amino acid
AWC34_RS01745	COG2040	homocysteine
AWC34_RS01750	COG3239	Fatty acid desaturase
AWC34_RS01765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWC34_RS01775	COG0667	Aldo Keto reductase
AWC34_RS01785	COG1522	sequence-specific DNA binding
AWC34_RS01790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWC34_RS01815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWC34_RS01820	COG1846	Transcriptional regulator
AWC34_RS01825	COG1063	alcohol dehydrogenase
AWC34_RS01830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWC34_RS01835	COG0697	spore germination
AWC34_RS01840	COG1063	alcohol dehydrogenase
AWC34_RS01845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWC34_RS01850	COG0693	protein deglycase activity
AWC34_RS01855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AWC34_RS01865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AWC34_RS01875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWC34_RS01880	COG2210	Belongs to the sulfur carrier protein TusA family
AWC34_RS01885	COG1937	Protein conserved in bacteria
AWC34_RS01890	COG0730	response to heat
AWC34_RS01895	COG1733	regulation of RNA biosynthetic process
AWC34_RS01900	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AWC34_RS01915	COG0702	epimerase
AWC34_RS01920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AWC34_RS01955	COG0415	Belongs to the DNA photolyase family
AWC34_RS01965	COG1136	(ABC) transporter
AWC34_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS02005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS02020	COG0546	phosphoglycolate phosphatase activity
AWC34_RS02030	COG1428	Deoxynucleoside kinase
AWC34_RS02035	COG1428	Deoxynucleoside kinase
AWC34_RS02045	COG0561	phosphatase activity
AWC34_RS02050	COG0431	NADPH-dependent FMN reductase
AWC34_RS02065	COG1469	GTP cyclohydrolase I activity
AWC34_RS02070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AWC34_RS02080	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AWC34_RS02090	COG1115	amino acid carrier protein
AWC34_RS02095	COG0318	PFAM AMP-dependent synthetase and ligase
AWC34_RS02100	COG0183	Belongs to the thiolase family
AWC34_RS02130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWC34_RS02140	COG2363	Small membrane protein
AWC34_RS02155	COG2966	Psort location CytoplasmicMembrane, score
AWC34_RS02160	COG3253	May function as heme-dependent peroxidase
AWC34_RS02165	COG0280	phosphate acetyltransferase
AWC34_RS02170	COG0095	Lipoate-protein ligase
AWC34_RS02175	COG0083	homoserine kinase activity
AWC34_RS02190	COG1263	PTS System
AWC34_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS02195	COG1737	Transcriptional regulator
AWC34_RS02200	COG0673	inositol 2-dehydrogenase activity
AWC34_RS02210	COG0673	inositol 2-dehydrogenase activity
AWC34_RS02215	COG1082	Xylose isomerase domain protein TIM barrel
AWC34_RS02220	COG4844	belongs to the
AWC34_RS02225	COG0667	Aldo Keto reductase
AWC34_RS02230	COG0655	NAD(P)H dehydrogenase (quinone) activity
AWC34_RS02235	COG0456	acetyltransferase
AWC34_RS02240	COG1078	dGTPase activity
AWC34_RS02255	COG0018	arginyl-trna synthetase
AWC34_RS02260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWC34_RS02265	COG0789	Transcriptional regulator
AWC34_RS02270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS02275	COG4139	cobalamin transport
AWC34_RS02280	COG0546	phosphoglycolate phosphatase activity
AWC34_RS02300	COG0596	Alpha beta hydrolase
AWC34_RS02335	COG4974	Belongs to the 'phage' integrase family
AWC34_RS02340	COG2111	Na H antiporter
AWC34_RS02340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWC34_RS02345	COG2111	Na H antiporter
AWC34_RS02350	COG1006	Multisubunit Na H antiporter MnhC subunit
AWC34_RS02355	COG0651	ATP synthesis coupled electron transport
AWC34_RS02360	COG1863	multisubunit Na H antiporter MnhE subunit
AWC34_RS02365	COG2212	antiporter activity
AWC34_RS02370	COG1320	monovalent cation:proton antiporter activity
AWC34_RS02380	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWC34_RS02385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWC34_RS02390	COG1121	(ABC) transporter
AWC34_RS02405	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AWC34_RS02410	COG1134	teichoic acid transport
AWC34_RS02415	COG1682	transport, permease protein
AWC34_RS02420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWC34_RS02430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AWC34_RS02440	COG1132	(ABC) transporter
AWC34_RS02445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AWC34_RS02450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWC34_RS02455	COG1120	ATPase activity
AWC34_RS02460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS02465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS02470	COG2376	Dihydroxyacetone kinase
AWC34_RS02475	COG1461	Dihydroxyacetone kinase
AWC34_RS02480	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWC34_RS02490	COG3949	Membrane
AWC34_RS02505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWC34_RS02510	COG0745	RESPONSE REGULATOR receiver
AWC34_RS02515	COG2205	protein histidine kinase activity
AWC34_RS02520	COG1392	Phosphate transport regulator
AWC34_RS02525	COG0306	phosphate transporter
AWC34_RS02530	COG3942	CHAP domain
AWC34_RS02530	COG1388	LysM domain
AWC34_RS02545	COG0217	transcriptional regulatory protein
AWC34_RS02555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWC34_RS02565	COG0583	DNA-binding transcription factor activity
AWC34_RS02575	COG2839	Protein conserved in bacteria
AWC34_RS02580	COG2814	Major facilitator Superfamily
AWC34_RS02610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWC34_RS02615	COG1279	arginine transmembrane transporter activity
AWC34_RS02620	COG1611	Belongs to the LOG family
AWC34_RS02625	COG1671	Belongs to the UPF0178 family
AWC34_RS02635	COG1968	undecaprenyl-diphosphatase activity
AWC34_RS02640	COG4988	ABC transporter
AWC34_RS02645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AWC34_RS02655	COG0523	cobalamin synthesis protein
AWC34_RS02660	COG4989	oxidoreductase activity
AWC34_RS02670	COG0586	Pfam SNARE associated Golgi protein
AWC34_RS02675	COG0039	L-malate dehydrogenase activity
AWC34_RS02705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWC34_RS02710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWC34_RS02715	COG1349	DNA-binding transcription factor activity
AWC34_RS02720	COG1105	Belongs to the carbohydrate kinase PfkB family
AWC34_RS02725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWC34_RS02725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWC34_RS02725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS02730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWC34_RS02735	COG1253	flavin adenine dinucleotide binding
AWC34_RS02740	COG0656	L-ascorbic acid biosynthetic process
AWC34_RS02745	COG0463	Glycosyl transferase, family 2
AWC34_RS02760	COG0602	queuosine metabolic process
AWC34_RS02765	COG0720	synthase
AWC34_RS02770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AWC34_RS02775	COG0512	Glutamine amidotransferase of anthranilate synthase
AWC34_RS02780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWC34_RS02795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWC34_RS02805	COG1368	sulfuric ester hydrolase activity
AWC34_RS02815	COG0488	(ABC) transporter
AWC34_RS02820	COG0514	ATP-dependent DNA helicase (RecQ)
AWC34_RS02830	COG1174	glycine betaine transport
AWC34_RS02835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWC34_RS02845	COG1597	lipid kinase activity
AWC34_RS02850	COG3104	oligopeptide transport
AWC34_RS02855	COG3104	oligopeptide transport
AWC34_RS02860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AWC34_RS02870	COG1780	Probably involved in ribonucleotide reductase function
AWC34_RS02875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWC34_RS02880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWC34_RS02885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS02890	COG4605	iron ion homeostasis
AWC34_RS02895	COG4604	ABC transporter, ATP-binding protein
AWC34_RS02900	COG4607	ABC-type enterochelin transport system periplasmic component
AWC34_RS02915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWC34_RS02935	COG1929	Belongs to the glycerate kinase type-1 family
AWC34_RS02940	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWC34_RS02955	COG2199	diguanylate cyclase activity
AWC34_RS02960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWC34_RS02965	COG1739	Uncharacterized protein family UPF0029
AWC34_RS02975	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWC34_RS02980	COG1040	competence protein
AWC34_RS02985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AWC34_RS02990	COG0653	protein targeting
AWC34_RS02995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWC34_RS03000	COG3942	CHAP domain
AWC34_RS03000	COG1388	LysM domain
AWC34_RS03015	COG0556	nucleotide-excision repair
AWC34_RS03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWC34_RS03025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWC34_RS03030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWC34_RS03035	COG0110	maltose O-acetyltransferase activity
AWC34_RS03050	COG1660	Displays ATPase and GTPase activities
AWC34_RS03055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWC34_RS03060	COG1481	regulation of sporulation
AWC34_RS03065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWC34_RS03075	COG0740	serine-type endopeptidase activity
AWC34_RS03080	COG1090	epimerase
AWC34_RS03110	COG0126	phosphoglycerate kinase activity
AWC34_RS03115	COG0149	triose-phosphate isomerase activity
AWC34_RS03120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWC34_RS03125	COG0148	phosphopyruvate hydratase activity
AWC34_RS03135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWC34_RS03140	COG1647	Serine aminopeptidase, S33
AWC34_RS03145	COG0557	exoribonuclease II activity
AWC34_RS03150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWC34_RS03210	COG0384	phenazine biosynthesis protein PhzF
AWC34_RS03230	COG1278	Cold shock
AWC34_RS03275	COG0346	lactoylglutathione lyase activity
AWC34_RS03315	COG2314	TM2 domain
AWC34_RS03330	COG2851	Citrate transporter
AWC34_RS03345	COG1764	response to oxidative stress
AWC34_RS03350	COG0710	3-dehydroquinate dehydratase activity
AWC34_RS03355	COG0778	Nitroreductase
AWC34_RS03360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWC34_RS03365	COG1393	Belongs to the ArsC family
AWC34_RS03370	COG0509	glycine decarboxylation via glycine cleavage system
AWC34_RS03375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWC34_RS03380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWC34_RS03385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWC34_RS03390	COG2011	ABC-type metal ion transport system permease component
AWC34_RS03395	COG1464	Belongs to the NlpA lipoprotein family
AWC34_RS03405	COG1253	flavin adenine dinucleotide binding
AWC34_RS03415	COG0396	ATPase activity
AWC34_RS03420	COG0719	Fe-S assembly protein
AWC34_RS03425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWC34_RS03430	COG0822	iron-sulfur transferase activity
AWC34_RS03435	COG0719	Fe-S assembly protein
AWC34_RS03440	COG4536	flavin adenine dinucleotide binding
AWC34_RS03445	COG2070	2-Nitropropane dioxygenase
AWC34_RS03450	COG1801	Protein of unknown function DUF72
AWC34_RS03455	COG0730	response to heat
AWC34_RS03460	COG0737	Belongs to the 5'-nucleotidase family
AWC34_RS03465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AWC34_RS03470	COG4470	Protein conserved in bacteria
AWC34_RS03480	COG2445	Protein of unknown function DUF86
AWC34_RS03485	COG0647	UMP catabolic process
AWC34_RS03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWC34_RS03510	COG1696	Membrane protein involved in D-alanine export
AWC34_RS03515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWC34_RS03520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AWC34_RS03525	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AWC34_RS03530	COG4837	Protein of unknown function (DUF1462)
AWC34_RS03535	COG1252	NADH dehydrogenase
AWC34_RS03540	COG4844	belongs to the
AWC34_RS03545	COG0316	Belongs to the HesB IscA family
AWC34_RS03550	COG1252	NADH dehydrogenase
AWC34_RS03555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AWC34_RS03560	COG2056	Na+-H+ antiporter family
AWC34_RS03565	COG2050	protein possibly involved in aromatic compounds catabolism
AWC34_RS03575	COG1320	monovalent cation:proton antiporter activity
AWC34_RS03580	COG2212	antiporter activity
AWC34_RS03585	COG1863	multisubunit Na H antiporter MnhE subunit
AWC34_RS03590	COG0651	ATP synthesis coupled electron transport
AWC34_RS03595	COG1006	Multisubunit Na H antiporter MnhC subunit
AWC34_RS03600	COG2111	Na H antiporter
AWC34_RS03605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWC34_RS03605	COG2111	Na H antiporter
AWC34_RS03615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWC34_RS03620	COG1098	S1 RNA binding domain
AWC34_RS03625	COG1902	pentaerythritol trinitrate reductase activity
AWC34_RS03630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWC34_RS03650	COG2832	Protein of unknown function (DUF454)
AWC34_RS03655	COG0584	glycerophosphoryl diester phosphodiesterase
AWC34_RS03660	COG0165	Argininosuccinate lyase
AWC34_RS03665	COG0137	argininosuccinate synthase activity
AWC34_RS03670	COG0166	Belongs to the GPI family
AWC34_RS03675	COG0398	Pfam SNARE associated Golgi protein
AWC34_RS03690	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWC34_RS03695	COG1074	ATP-dependent DNA helicase activity
AWC34_RS03700	COG2311	Membrane
AWC34_RS03705	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWC34_RS03715	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWC34_RS03720	COG0561	phosphatase activity
AWC34_RS03740	COG0542	response to heat
AWC34_RS03750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWC34_RS03770	COG0601	transmembrane transport
AWC34_RS03775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWC34_RS03780	COG0444	Belongs to the ABC transporter superfamily
AWC34_RS03785	COG4608	Belongs to the ABC transporter superfamily
AWC34_RS03790	COG4166	transmembrane transport
AWC34_RS03795	COG0180	Tryptophanyl-tRNA synthetase
AWC34_RS03800	COG1393	Belongs to the ArsC family
AWC34_RS03805	COG4862	establishment of competence for transformation
AWC34_RS03815	COG1164	Oligoendopeptidase f
AWC34_RS03820	COG2910	NAD(P)H-binding
AWC34_RS03825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWC34_RS03830	COG2346	COG2346, Truncated hemoglobins
AWC34_RS03835	COG4116	CYTH
AWC34_RS03845	COG2357	RelA SpoT domain protein
AWC34_RS03850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWC34_RS03855	COG0564	pseudouridine synthase activity
AWC34_RS03860	COG2239	Acts as a magnesium transporter
AWC34_RS03865	COG0475	glutathione-regulated potassium exporter activity
AWC34_RS03865	COG0569	domain protein
AWC34_RS03875	COG0628	permease
AWC34_RS03880	COG1115	amino acid carrier protein
AWC34_RS03885	COG2382	esterase
AWC34_RS03890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AWC34_RS03895	COG2814	Major facilitator Superfamily
AWC34_RS03900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWC34_RS03905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWC34_RS03915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWC34_RS03920	COG0861	Integral membrane protein TerC family
AWC34_RS03925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWC34_RS03930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWC34_RS03935	COG0737	Belongs to the 5'-nucleotidase family
AWC34_RS03945	COG4873	Protein conserved in bacteria
AWC34_RS03960	COG4903	ComK protein
AWC34_RS03980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AWC34_RS03985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWC34_RS03995	COG2314	TM2 domain
AWC34_RS04005	COG1575	Belongs to the MenA family. Type 1 subfamily
AWC34_RS04010	COG1169	isochorismate synthase
AWC34_RS04015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AWC34_RS04025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AWC34_RS04035	COG0436	Aminotransferase
AWC34_RS04040	COG3594	Acyltransferase
AWC34_RS04065	COG1316	TRANSCRIPTIONal
AWC34_RS04070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWC34_RS04085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AWC34_RS04090	COG1845	cytochrome c oxidase, subunit III
AWC34_RS04095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWC34_RS04100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWC34_RS04115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWC34_RS04120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWC34_RS04125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWC34_RS04130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWC34_RS04135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWC34_RS04140	COG0047	phosphoribosylformylglycinamidine synthase activity
AWC34_RS04145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWC34_RS04155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWC34_RS04165	COG0138	bifunctional purine biosynthesis protein purh
AWC34_RS04170	COG0151	Belongs to the GarS family
AWC34_RS04180	COG4172	Belongs to the ABC transporter superfamily
AWC34_RS04195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWC34_RS04205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS04210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWC34_RS04220	COG1271	oxidase subunit
AWC34_RS04225	COG1294	oxidase, subunit
AWC34_RS04230	COG0569	domain protein
AWC34_RS04235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWC34_RS04240	COG5503	Protein of unknown function (DUF1447)
AWC34_RS04250	COG0242	peptide deformylase activity
AWC34_RS04270	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWC34_RS04280	COG4476	Belongs to the UPF0223 family
AWC34_RS04285	COG3842	ATPase activity
AWC34_RS04295	COG1177	transmembrane transport
AWC34_RS04315	COG4493	Belongs to the UPF0637 family
AWC34_RS04320	COG0483	inositol monophosphate 1-phosphatase activity
AWC34_RS04330	COG1217	gtp-binding protein TYPA
AWC34_RS04335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AWC34_RS04340	COG4838	Belongs to the UPF0358 family
AWC34_RS04345	COG0772	Belongs to the SEDS family
AWC34_RS04355	COG1612	heme a metabolic process
AWC34_RS04360	COG0109	protoheme IX farnesyltransferase activity
AWC34_RS04380	COG3679	Belongs to the UPF0342 family
AWC34_RS04390	COG4471	UPF0298 protein
AWC34_RS04400	COG0742	ribosomal rna small subunit methyltransferase
AWC34_RS04405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWC34_RS04410	COG1323	Belongs to the UPF0348 family
AWC34_RS04420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWC34_RS04430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWC34_RS04435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWC34_RS04440	COG0072	phenylalanine-tRNA ligase activity
AWC34_RS04445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWC34_RS04450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AWC34_RS04460	COG1796	DNA polymerase
AWC34_RS04460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWC34_RS04465	COG1193	negative regulation of DNA recombination
AWC34_RS04470	COG3118	belongs to the thioredoxin family
AWC34_RS04475	COG0322	excinuclease ABC activity
AWC34_RS04480	COG2009	succinate dehydrogenase
AWC34_RS04485	COG1053	succinate dehydrogenase
AWC34_RS04490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AWC34_RS04495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AWC34_RS04520	COG0584	glycerophosphoryl diester phosphodiesterase
AWC34_RS04555	COG1011	Hydrolase
AWC34_RS04560	COG0454	-acetyltransferase
AWC34_RS04565	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AWC34_RS04570	COG2001	Belongs to the MraZ family
AWC34_RS04575	COG0275	rRNA processing
AWC34_RS04580	COG4839	cell division protein FtsL
AWC34_RS04585	COG0768	penicillin binding
AWC34_RS04590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWC34_RS04595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWC34_RS04600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWC34_RS04605	COG0849	cell division
AWC34_RS04610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWC34_RS04615	COG1496	oxidoreductase activity
AWC34_RS04620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWC34_RS04625	COG1799	cell septum assembly
AWC34_RS04630	COG0762	integral membrane protein
AWC34_RS04635	COG2302	S4 RNA-binding domain
AWC34_RS04640	COG3599	regulation of cell shape
AWC34_RS04645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWC34_RS04655	COG3942	CHAP domain
AWC34_RS04655	COG1388	LysM domain
AWC34_RS04660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWC34_RS04665	COG0564	pseudouridine synthase activity
AWC34_RS04670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWC34_RS04680	COG0540	Belongs to the ATCase OTCase family
AWC34_RS04690	COG0505	Belongs to the CarA family
AWC34_RS04695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWC34_RS04700	COG0284	orotidine-5'-phosphate decarboxylase activity
AWC34_RS04705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWC34_RS04715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWC34_RS04725	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AWC34_RS04730	COG0194	GDP metabolic process
AWC34_RS04735	COG1758	RNA polymerase activity
AWC34_RS04740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWC34_RS04745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWC34_RS04760	COG0242	peptide deformylase activity
AWC34_RS04765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWC34_RS04770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWC34_RS04770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWC34_RS04775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWC34_RS04780	COG0631	protein serine/threonine phosphatase activity
AWC34_RS04790	COG1162	GTPase activity
AWC34_RS04795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWC34_RS04800	COG1564	THIamine pyrophosphokinase
AWC34_RS04805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWC34_RS04810	COG1302	Protein conserved in bacteria
AWC34_RS04815	COG1461	Dihydroxyacetone kinase
AWC34_RS04820	COG1760	l-serine dehydratase
AWC34_RS04825	COG1760	l-serine dehydratase
AWC34_RS04830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWC34_RS04840	COG1349	DNA-binding transcription factor activity
AWC34_RS04845	COG0416	fatty acid biosynthetic process
AWC34_RS04860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWC34_RS04865	COG0571	ribonuclease III activity
AWC34_RS04870	COG1196	nuclear chromosome segregation
AWC34_RS04875	COG0552	protein localization to endoplasmic reticulum
AWC34_RS04885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWC34_RS04890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS04895	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS04900	COG0228	four-way junction DNA binding
AWC34_RS04905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWC34_RS04910	COG0336	Belongs to the RNA methyltransferase TrmD family
AWC34_RS04915	COG0335	large ribosomal subunit rRNA binding
AWC34_RS04925	COG4485	Bacterial membrane protein, YfhO
AWC34_RS04935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWC34_RS04940	COG0045	succinate-CoA ligase (ADP-forming) activity
AWC34_RS04950	COG0758	DNA mediated transformation
AWC34_RS04955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWC34_RS04960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AWC34_RS04965	COG4974	Belongs to the 'phage' integrase family
AWC34_RS04970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AWC34_RS04975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AWC34_RS04980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWC34_RS04985	COG0052	Belongs to the universal ribosomal protein uS2 family
AWC34_RS04990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWC34_RS04995	COG0528	UMP kinase activity
AWC34_RS05000	COG0233	cytoplasmic translational termination
AWC34_RS05005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWC34_RS05010	COG4589	Belongs to the CDS family
AWC34_RS05020	COG0442	prolyl-tRNA aminoacylation
AWC34_RS05025	COG2176	DNA-directed DNA polymerase activity
AWC34_RS05030	COG0779	Required for maturation of 30S ribosomal subunits
AWC34_RS05035	COG0195	Participates in both transcription termination and antitermination
AWC34_RS05040	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWC34_RS05045	COG1358	cellular component organization or biogenesis
AWC34_RS05050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWC34_RS05065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWC34_RS05070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWC34_RS05075	COG0196	riboflavin kinase activity
AWC34_RS05080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWC34_RS05085	COG1185	polyribonucleotide nucleotidyltransferase activity
AWC34_RS05090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWC34_RS05095	COG1674	ftsk spoiiie
AWC34_RS05100	COG2188	Transcriptional regulator
AWC34_RS05105	COG0612	Peptidase, M16
AWC34_RS05110	COG0612	Peptidase, M16
AWC34_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS05135	COG1058	Belongs to the CinA family
AWC34_RS05135	COG1546	Belongs to the CinA family
AWC34_RS05140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWC34_RS05145	COG1418	mRNA catabolic process
AWC34_RS05155	COG1692	metallophosphoesterase
AWC34_RS05160	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWC34_RS05160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWC34_RS05165	COG1013	pyruvate-flavodoxin oxidoreductase activity
AWC34_RS05175	COG1959	2 iron, 2 sulfur cluster binding
AWC34_RS05180	COG0492	ferredoxin-NADP+ reductase activity
AWC34_RS05190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWC34_RS05195	COG4550	Control of competence regulator ComK, YlbF/YmcA
AWC34_RS05205	COG2207	Transcriptional regulator
AWC34_RS05215	COG1472	Belongs to the glycosyl hydrolase 3 family
AWC34_RS05220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWC34_RS05225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWC34_RS05235	COG1619	proteins homologs of microcin C7 resistance protein MccF
AWC34_RS05240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWC34_RS05245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWC34_RS05250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWC34_RS05275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWC34_RS05280	COG1923	regulation of RNA biosynthetic process
AWC34_RS05285	COG0386	Belongs to the glutathione peroxidase family
AWC34_RS05290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWC34_RS05295	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AWC34_RS05300	COG0789	Transcriptional regulator
AWC34_RS05305	COG0174	glutamine synthetase
AWC34_RS05350	COG0527	aspartate kinase activity
AWC34_RS05355	COG0460	homoserine dehydrogenase
AWC34_RS05360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AWC34_RS05365	COG0083	homoserine kinase activity
AWC34_RS05380	COG0833	amino acid
AWC34_RS05385	COG0753	catalase activity
AWC34_RS05395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWC34_RS05400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWC34_RS05405	COG0516	GMP reductase activity
AWC34_RS05415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWC34_RS05435	COG3763	UPF0154 protein
AWC34_RS05445	COG4846	Membrane protein involved in cytochrome C biogenesis
AWC34_RS05450	COG0420	3'-5' exonuclease activity
AWC34_RS05455	COG0419	ATPase involved in DNA repair
AWC34_RS05460	COG1970	mechanosensitive ion channel activity
AWC34_RS05465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWC34_RS05470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AWC34_RS05480	COG4841	protein insertion into membrane
AWC34_RS05485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWC34_RS05495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWC34_RS05500	COG1115	amino acid carrier protein
AWC34_RS05505	COG3711	transcriptional antiterminator
AWC34_RS05515	COG0628	permease
AWC34_RS05520	COG0392	lysyltransferase activity
AWC34_RS05520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AWC34_RS05530	COG1609	Transcriptional regulator
AWC34_RS05535	COG1869	D-ribose catabolic process
AWC34_RS05540	COG1129	ABC transporter
AWC34_RS05545	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWC34_RS05550	COG1879	ABC-type sugar transport system periplasmic component
AWC34_RS05565	COG1942	4-Oxalocrotonate Tautomerase
AWC34_RS05570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWC34_RS05575	COG0287	Prephenate dehydrogenase
AWC34_RS05590	COG1363	Peptidase, m42
AWC34_RS05600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWC34_RS05605	COG0512	Glutamine amidotransferase of anthranilate synthase
AWC34_RS05610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWC34_RS05615	COG0134	indole-3-glycerol-phosphate synthase activity
AWC34_RS05625	COG0133	tryptophan synthase activity
AWC34_RS05630	COG0159	tryptophan synthase activity
AWC34_RS05660	COG1164	Oligoendopeptidase f
AWC34_RS05670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWC34_RS05675	COG0581	inorganic phosphate transmembrane transporter activity
AWC34_RS05680	COG0573	inorganic phosphate transmembrane transporter activity
AWC34_RS05685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWC34_RS05690	COG2996	Protein conserved in bacteria
AWC34_RS05695	COG0488	(ABC) transporter
AWC34_RS05705	COG0527	aspartate kinase activity
AWC34_RS05710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWC34_RS05715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWC34_RS05720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWC34_RS05730	COG1473	amidohydrolase
AWC34_RS05745	COG1278	Cold shock
AWC34_RS05755	COG1254	Belongs to the acylphosphatase family
AWC34_RS05765	COG3853	Toxic anion resistance protein (TelA)
AWC34_RS05770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWC34_RS05775	COG1114	Component of the transport system for branched-chain amino acids
AWC34_RS05780	COG4548	von Willebrand factor, type A
AWC34_RS05785	COG0714	Associated with various cellular activities
AWC34_RS05805	COG4152	abc transporter atp-binding protein
AWC34_RS05810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWC34_RS05815	COG0673	inositol 2-dehydrogenase activity
AWC34_RS05825	COG1082	Xylose isomerase domain protein TIM barrel
AWC34_RS05835	COG1917	Cupin 2, conserved barrel domain protein
AWC34_RS05835	COG2207	Transcriptional regulator
AWC34_RS05845	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWC34_RS05850	COG0567	Dehydrogenase, E1 component
AWC34_RS05855	COG5002	protein histidine kinase activity
AWC34_RS05860	COG0745	RESPONSE REGULATOR receiver
AWC34_RS05865	COG0671	phosphoesterase, PA-phosphatase related
AWC34_RS05870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWC34_RS05880	COG0793	Belongs to the peptidase S41A family
AWC34_RS05885	COG4479	Belongs to the UPF0346 family
AWC34_RS05895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWC34_RS05915	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWC34_RS05925	COG1413	lyase activity
AWC34_RS05930	COG1413	lyase activity
AWC34_RS05940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AWC34_RS05950	COG0328	RNA-DNA hybrid ribonuclease activity
AWC34_RS05955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWC34_RS05960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AWC34_RS05970	COG2962	Rard protein
AWC34_RS05975	COG0116	Belongs to the methyltransferase superfamily
AWC34_RS05990	COG4474	Belongs to the UPF0398 family
AWC34_RS06000	COG3331	DNA recombination
AWC34_RS06005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWC34_RS06005	COG4499	WXG100 protein secretion system (Wss), protein YukC
AWC34_RS06015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWC34_RS06020	COG3935	DnaD domain protein
AWC34_RS06025	COG0017	Asparaginyl-tRNA synthetase
AWC34_RS06030	COG1199	ATP-dependent helicase activity
AWC34_RS06030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWC34_RS06040	COG0617	tRNA 3'-terminal CCA addition
AWC34_RS06045	COG0438	transferase activity, transferring glycosyl groups
AWC34_RS06050	COG1694	Mazg nucleotide pyrophosphohydrolase
AWC34_RS06055	COG2738	Putative neutral zinc metallopeptidase
AWC34_RS06060	COG4347	Protein of unknown function (DUF1405)
AWC34_RS06065	COG5582	Belongs to the UPF0302 family
AWC34_RS06075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWC34_RS06080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWC34_RS06085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWC34_RS06090	COG0105	UTP biosynthetic process
AWC34_RS06095	COG0142	geranyltranstransferase activity
AWC34_RS06100	COG2226	methyltransferase
AWC34_RS06115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWC34_RS06120	COG1160	GTP binding
AWC34_RS06125	COG0539	negative regulation of cytoplasmic translation
AWC34_RS06130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWC34_RS06140	COG0492	ferredoxin-NADP+ reductase activity
AWC34_RS06145	COG1388	LysM domain
AWC34_RS06145	COG1388	LysM domain
AWC34_RS06150	COG0514	ATP-dependent DNA helicase (RecQ)
AWC34_RS06160	COG1141	Ferredoxin
AWC34_RS06175	COG0745	RESPONSE REGULATOR receiver
AWC34_RS06180	COG1187	pseudouridine synthase activity
AWC34_RS06185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWC34_RS06190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWC34_RS06200	COG4974	Belongs to the 'phage' integrase family
AWC34_RS06205	COG0735	belongs to the Fur family
AWC34_RS06210	COG0494	nUDIX hydrolase
AWC34_RS06215	COG0667	Aldo Keto reductase
AWC34_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS06225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWC34_RS06230	COG1234	tRNA 3'-trailer cleavage
AWC34_RS06235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWC34_RS06245	COG0366	Alpha amylase catalytic
AWC34_RS06260	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWC34_RS06265	COG4129	membrane
AWC34_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWC34_RS06280	COG0022	dehydrogenase e1 component
AWC34_RS06285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWC34_RS06290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWC34_RS06300	COG0280	phosphate acetyltransferase
AWC34_RS06305	COG0497	DNA recombination
AWC34_RS06310	COG1438	arginine binding
AWC34_RS06320	COG1722	exodeoxyribonuclease VII activity
AWC34_RS06325	COG1570	exodeoxyribonuclease VII activity
AWC34_RS06330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWC34_RS06335	COG1302	Protein conserved in bacteria
AWC34_RS06340	COG0439	Biotin carboxylase
AWC34_RS06345	COG0511	ligase activity, forming carbon-carbon bonds
AWC34_RS06350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWC34_RS06355	COG0006	proline dipeptidase activity
AWC34_RS06370	COG0095	Lipoate-protein ligase
AWC34_RS06375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWC34_RS06380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWC34_RS06385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWC34_RS06390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWC34_RS06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWC34_RS06420	COG4537	Required for transformation and DNA binding
AWC34_RS06430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWC34_RS06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWC34_RS06440	COG0011	TIGRFAM Protein of
AWC34_RS06445	COG1940	carbohydrate kinase activity
AWC34_RS06450	COG4483	Protein conserved in bacteria
AWC34_RS06460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWC34_RS06465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWC34_RS06470	COG0768	penicillin binding
AWC34_RS06475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWC34_RS06485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWC34_RS06490	COG1121	(ABC) transporter
AWC34_RS06495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWC34_RS06500	COG0513	Belongs to the DEAD box helicase family
AWC34_RS06505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWC34_RS06510	COG2384	SAM-dependent methyltransferase
AWC34_RS06515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWC34_RS06525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWC34_RS06530	COG0517	IMP dehydrogenase activity
AWC34_RS06535	COG0423	glycine-tRNA ligase activity
AWC34_RS06540	COG1381	Involved in DNA repair and RecF pathway recombination
AWC34_RS06545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWC34_RS06555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AWC34_RS06560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWC34_RS06565	COG1702	phosphate starvation-inducible protein PhoH
AWC34_RS06575	COG4864	UPF0365 protein
AWC34_RS06585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWC34_RS06590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWC34_RS06595	COG2264	protein methyltransferase activity
AWC34_RS06600	COG0484	heat shock protein binding
AWC34_RS06605	COG0443	Heat shock 70 kDa protein
AWC34_RS06610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWC34_RS06615	COG1420	regulation of RNA biosynthetic process
AWC34_RS06620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWC34_RS06625	COG0481	GTPase activity
AWC34_RS06630	COG0268	Binds directly to 16S ribosomal RNA
AWC34_RS06635	COG1466	dna polymerase III delta subunit
AWC34_RS06640	COG2333	competence protein COMEC
AWC34_RS06640	COG0658	competence protein
AWC34_RS06645	COG2131	deaminase
AWC34_RS06650	COG1555	photosystem II stabilization
AWC34_RS06650	COG1596	polysaccharide export
AWC34_RS06655	COG2226	methyltransferase
AWC34_RS06660	COG0799	negative regulation of ribosome biogenesis
AWC34_RS06665	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWC34_RS06670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWC34_RS06675	COG1534	Rna-binding protein
AWC34_RS06680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWC34_RS06685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWC34_RS06690	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AWC34_RS06695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWC34_RS06700	COG1914	H( )-stimulated, divalent metal cation uptake system
AWC34_RS06705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AWC34_RS06710	COG0439	Biotin carboxylase
AWC34_RS06720	COG1984	allophanate hydrolase subunit 2
AWC34_RS06725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWC34_RS06730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWC34_RS06735	COG0572	uridine kinase
AWC34_RS06740	COG0826	peptidase U32
AWC34_RS06745	COG0826	peptidase U32
AWC34_RS06750	COG4122	O-methyltransferase activity
AWC34_RS06755	COG3906	Belongs to the UPF0473 family
AWC34_RS06760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AWC34_RS06765	COG4472	Bacterial protein of unknown function (DUF965)
AWC34_RS06770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWC34_RS06775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWC34_RS06785	COG0482	sulfurtransferase activity
AWC34_RS06790	COG1104	cysteine desulfurase activity
AWC34_RS06795	COG0488	(ABC) transporter
AWC34_RS06800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS06810	COG3237	CsbD-like
AWC34_RS06815	COG1959	2 iron, 2 sulfur cluster binding
AWC34_RS06820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWC34_RS06825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AWC34_RS06835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWC34_RS06840	COG0124	histidyl-tRNA synthetase
AWC34_RS06845	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWC34_RS06850	COG1490	D-aminoacyl-tRNA deacylase activity
AWC34_RS06855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWC34_RS06865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWC34_RS06865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWC34_RS06870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWC34_RS06870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWC34_RS06875	COG1862	Preprotein translocase
AWC34_RS06880	COG0343	queuine tRNA-ribosyltransferase activity
AWC34_RS06885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWC34_RS06890	COG2255	four-way junction helicase activity
AWC34_RS06895	COG0632	four-way junction helicase activity
AWC34_RS06900	COG4492	Belongs to the UPF0735 family
AWC34_RS06905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AWC34_RS06910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWC34_RS06915	COG2868	ribosomal protein
AWC34_RS06945	COG0656	L-ascorbic acid biosynthetic process
AWC34_RS06960	COG2003	Belongs to the UPF0758 family
AWC34_RS06975	COG0285	dihydrofolate synthase activity
AWC34_RS06980	COG0525	valine-tRNA ligase activity
AWC34_RS06985	COG2818	Glycosylase
AWC34_RS06995	COG3180	Ammonia monooxygenase
AWC34_RS07000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWC34_RS07005	COG0113	porphobilinogen synthase activity
AWC34_RS07010	COG1587	Uroporphyrinogen-III synthase
AWC34_RS07015	COG0181	hydroxymethylbilane synthase activity
AWC34_RS07020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWC34_RS07025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AWC34_RS07030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWC34_RS07035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWC34_RS07040	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWC34_RS07050	COG4112	unkown
AWC34_RS07055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWC34_RS07060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AWC34_RS07065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWC34_RS07070	COG0833	amino acid
AWC34_RS07075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWC34_RS07080	COG1484	DNA-dependent DNA replication
AWC34_RS07090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWC34_RS07095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWC34_RS07100	COG0237	dephospho-CoA kinase activity
AWC34_RS07105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWC34_RS07110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWC34_RS07110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWC34_RS07115	COG5002	protein histidine kinase activity
AWC34_RS07120	COG0745	RESPONSE REGULATOR receiver
AWC34_RS07125	COG0538	isocitrate dehydrogenase activity
AWC34_RS07130	COG0372	Belongs to the citrate synthase family
AWC34_RS07135	COG1113	amino acid transport
AWC34_RS07140	COG0469	pyruvate kinase activity
AWC34_RS07145	COG0205	6-phosphofructokinase activity
AWC34_RS07150	COG0825	malonyl-CoA metabolic process
AWC34_RS07155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWC34_RS07160	COG0281	malic enzyme
AWC34_RS07165	COG0587	DNA-directed DNA polymerase activity
AWC34_RS07170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWC34_RS07175	COG4109	DRTGG domain
AWC34_RS07185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWC34_RS07190	COG0006	proline dipeptidase activity
AWC34_RS07195	COG3142	Participates in the control of copper homeostasis
AWC34_RS07200	COG0686	Belongs to the AlaDH PNT family
AWC34_RS07205	COG0589	response to stress
AWC34_RS07215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWC34_RS07220	COG0827	DNA restriction-modification system
AWC34_RS07225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWC34_RS07230	COG1714	RDD family
AWC34_RS07235	COG0616	signal peptide processing
AWC34_RS07245	COG0301	tRNA thio-modification
AWC34_RS07250	COG1104	cysteine desulfurase activity
AWC34_RS07255	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWC34_RS07260	COG1956	GAF domain-containing protein
AWC34_RS07265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWC34_RS07275	COG0584	glycerophosphoryl diester phosphodiesterase
AWC34_RS07280	COG1764	response to oxidative stress
AWC34_RS07285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWC34_RS07290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWC34_RS07300	COG1263	PTS System
AWC34_RS07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS07305	COG0204	Acyl-transferase
AWC34_RS07310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWC34_RS07315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWC34_RS07330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWC34_RS07335	COG0454	-acetyltransferase
AWC34_RS07340	COG0123	including yeast histone deacetylase and acetoin utilization protein
AWC34_RS07345	COG1609	Transcriptional regulator
AWC34_RS07350	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWC34_RS07350	COG1605	Chorismate mutase
AWC34_RS07360	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AWC34_RS07365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWC34_RS07370	COG1674	ftsk spoiiie
AWC34_RS07375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWC34_RS07380	COG4848	Belongs to the UPF0354 family
AWC34_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWC34_RS07390	COG1363	Peptidase, m42
AWC34_RS07395	COG5584	Small secreted protein
AWC34_RS07400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWC34_RS07405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWC34_RS07410	COG0510	thiamine kinase activity
AWC34_RS07420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWC34_RS07430	COG1187	pseudouridine synthase activity
AWC34_RS07435	COG2244	polysaccharide biosynthetic process
AWC34_RS07440	COG2081	HI0933 family
AWC34_RS07450	COG0495	leucyl-tRNA aminoacylation
AWC34_RS07455	COG2814	Major facilitator Superfamily
AWC34_RS07460	COG1242	4 iron, 4 sulfur cluster binding
AWC34_RS07465	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWC34_RS07475	COG0039	L-malate dehydrogenase activity
AWC34_RS07480	COG2267	carboxylic ester hydrolase activity
AWC34_RS07485	COG0506	proline dehydrogenase activity
AWC34_RS07490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AWC34_RS07495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWC34_RS07495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWC34_RS07500	COG0307	riboflavin synthase, alpha
AWC34_RS07505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWC34_RS07505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWC34_RS07520	COG3266	domain, Protein
AWC34_RS07520	COG5632	N-Acetylmuramoyl-L-alanine amidase
AWC34_RS07520	COG4193	domain, Protein
AWC34_RS07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWC34_RS07560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWC34_RS07565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWC34_RS07570	COG0656	L-ascorbic acid biosynthetic process
AWC34_RS07580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWC34_RS07585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AWC34_RS07590	COG1506	peptidase
AWC34_RS07600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWC34_RS07630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AWC34_RS07675	COG3545	Serine hydrolase
AWC34_RS07680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AWC34_RS07685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AWC34_RS07690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWC34_RS07700	COG4473	ABC transporter
AWC34_RS07705	COG1131	(ABC) transporter
AWC34_RS07710	COG0537	adenosine 5'-monophosphoramidase activity
AWC34_RS07725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWC34_RS07730	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWC34_RS07735	COG4717	serine-type aminopeptidase activity
AWC34_RS07740	COG0420	3'-5' exonuclease activity
AWC34_RS07745	COG3679	Belongs to the UPF0342 family
AWC34_RS07750	COG4399	Belongs to the UPF0754 family
AWC34_RS07760	COG0788	formyltetrahydrofolate deformylase activity
AWC34_RS07775	COG1301	dicarboxylic acid transport
AWC34_RS07780	COG2197	response regulator
AWC34_RS07785	COG4585	Histidine kinase
AWC34_RS07785	COG2203	Gaf domain
AWC34_RS07790	COG0564	pseudouridine synthase activity
AWC34_RS07795	COG0114	fumarate hydratase activity
AWC34_RS07810	COG0363	glucosamine-6-phosphate deaminase activity
AWC34_RS07820	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWC34_RS07825	COG1126	abc transporter atp-binding protein
AWC34_RS07830	COG0765	amino acid transport
AWC34_RS07980	COG0735	belongs to the Fur family
AWC34_RS07985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWC34_RS07990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AWC34_RS07995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWC34_RS08000	COG4129	membrane
AWC34_RS08010	COG3557	Belongs to the UPF0374 family
AWC34_RS08015	COG1194	a g-specific adenine glycosylase
AWC34_RS08020	COG1988	membrane-bound metal-dependent
AWC34_RS08040	COG2137	regulation of response to DNA damage stimulus
AWC34_RS08045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWC34_RS08050	COG0693	protein deglycase activity
AWC34_RS08055	COG1607	acyl-coa hydrolase
AWC34_RS08060	COG2309	aminopeptidase activity
AWC34_RS08065	COG4840	Belongs to the UPF0435 family
AWC34_RS08070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWC34_RS08080	COG1295	ribonuclease BN
AWC34_RS08085	COG2197	response regulator
AWC34_RS08090	COG4585	Histidine kinase
AWC34_RS08105	COG0024	Methionine aminopeptidase
AWC34_RS08110	COG4129	membrane
AWC34_RS08125	COG1528	Iron-storage protein
AWC34_RS08135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWC34_RS08145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWC34_RS08150	COG1597	lipid kinase activity
AWC34_RS08155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWC34_RS08160	COG0154	amidase activity
AWC34_RS08165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWC34_RS08170	COG4851	CamS sex pheromone cAM373 precursor
AWC34_RS08175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWC34_RS08180	COG0210	DNA helicase
AWC34_RS08185	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AWC34_RS08195	COG4496	protein, YerC YecD
AWC34_RS08200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWC34_RS08210	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWC34_RS08215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AWC34_RS08220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWC34_RS08230	COG0077	Prephenate dehydratase
AWC34_RS08235	COG0471	metal ion transport
AWC34_RS08245	COG1335	isochorismatase
AWC34_RS08250	COG1227	inorganic diphosphatase activity
AWC34_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS08260	COG2706	6-phosphogluconolactonase activity
AWC34_RS08300	COG1131	(ABC) transporter
AWC34_RS08315	COG1725	Transcriptional regulator
AWC34_RS08340	COG0459	protein refolding
AWC34_RS08345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWC34_RS08370	COG4512	PFAM Accessory gene regulator B
AWC34_RS08380	COG3290	protein histidine kinase activity
AWC34_RS08385	COG3279	Response regulator of the LytR AlgR family
AWC34_RS08395	COG1621	beta-fructofuranosidase activity
AWC34_RS08400	COG1609	Transcriptional regulator
AWC34_RS08405	COG0425	Belongs to the sulfur carrier protein TusA family
AWC34_RS08410	COG2391	methyltransferase activity
AWC34_RS08415	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AWC34_RS08420	COG0488	(ABC) transporter
AWC34_RS08430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWC34_RS08435	COG0456	acetyltransferase
AWC34_RS08440	COG1214	PFAM Peptidase M22, glycoprotease
AWC34_RS08445	COG0802	atpase or kinase
AWC34_RS08450	COG0129	dihydroxy-acid dehydratase activity
AWC34_RS08455	COG0028	Belongs to the TPP enzyme family
AWC34_RS08460	COG0440	acetolactate synthase activity
AWC34_RS08465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWC34_RS08470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWC34_RS08475	COG0473	3-isopropylmalate dehydrogenase activity
AWC34_RS08480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWC34_RS08485	COG0066	3-isopropylmalate dehydratase activity
AWC34_RS08490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWC34_RS08520	COG3091	SprT-like family
AWC34_RS08525	COG2183	response to ionizing radiation
AWC34_RS08530	COG1191	sigma factor activity
AWC34_RS08545	COG2208	phosphoserine phosphatase activity
AWC34_RS08550	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWC34_RS08560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AWC34_RS08565	COG0736	holo-[acyl-carrier-protein] synthase activity
AWC34_RS08575	COG3428	Bacterial PH domain
AWC34_RS08585	COG0513	Belongs to the DEAD box helicase family
AWC34_RS08590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWC34_RS08595	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWC34_RS08600	COG0772	Belongs to the SEDS family
AWC34_RS08610	COG1937	Protein conserved in bacteria
AWC34_RS08620	COG1418	mRNA catabolic process
AWC34_RS08625	COG0706	membrane insertase activity
AWC34_RS08630	COG0352	thiamine-phosphate diphosphorylase activity
AWC34_RS08635	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AWC34_RS08645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWC34_RS08650	COG1388	LysM domain
AWC34_RS08655	COG0629	single-stranded DNA binding
AWC34_RS08665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWC34_RS08670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWC34_RS08680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AWC34_RS08685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AWC34_RS08690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AWC34_RS08695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AWC34_RS08700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWC34_RS08705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWC34_RS08710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWC34_RS08715	COG0356	it plays a direct role in the translocation of protons across the membrane
AWC34_RS08725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWC34_RS08730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWC34_RS08735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWC34_RS08740	COG4475	Protein of unknown function (DUF436)
AWC34_RS08745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWC34_RS08750	COG0009	L-threonylcarbamoyladenylate synthase
AWC34_RS08755	COG2890	protein-(glutamine-N5) methyltransferase activity
AWC34_RS08760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWC34_RS08765	COG1435	thymidine kinase activity
AWC34_RS08770	COG0254	rRNA binding
AWC34_RS08775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWC34_RS08780	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS08790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWC34_RS08795	COG0191	fructose-bisphosphate aldolase activity
AWC34_RS08800	COG0504	CTP synthase activity
AWC34_RS08805	COG3343	RNA polymerase activity
AWC34_RS08810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWC34_RS08820	COG5146	pantothenate kinase activity
AWC34_RS08840	COG1854	S-ribosylhomocysteine lyase activity
AWC34_RS08850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AWC34_RS08855	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AWC34_RS08860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWC34_RS08865	COG0813	purine-nucleoside phosphorylase activity
AWC34_RS08870	COG0783	Belongs to the Dps family
AWC34_RS08875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWC34_RS08890	COG2855	membrane
AWC34_RS08900	COG1482	cell wall glycoprotein biosynthetic process
AWC34_RS08905	COG2186	Transcriptional regulator
AWC34_RS08910	COG0702	epimerase
AWC34_RS08915	COG0640	Transcriptional regulator
AWC34_RS08940	COG1119	ATPase activity
AWC34_RS08965	COG3711	transcriptional antiterminator
AWC34_RS08975	COG0246	Mannitol dehydrogenase
AWC34_RS08980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWC34_RS08990	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AWC34_RS09045	COG0489	protein tyrosine kinase activity
AWC34_RS09060	COG1272	protein, Hemolysin III
AWC34_RS09065	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AWC34_RS09070	COG1988	membrane-bound metal-dependent
AWC34_RS09080	COG2329	Antibiotic biosynthesis monooxygenase
AWC34_RS09085	COG3314	Sporulation integral membrane protein YlbJ
AWC34_RS09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS09095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS09100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AWC34_RS09105	COG3457	Alanine racemase
AWC34_RS09110	COG4264	IucA IucC family
AWC34_RS09115	COG4264	IucA IucC family
AWC34_RS09120	COG1302	Protein conserved in bacteria
AWC34_RS09135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWC34_RS09140	COG0604	alcohol dehydrogenase
AWC34_RS09145	COG2130	NADP-dependent
AWC34_RS09150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS09160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWC34_RS09165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWC34_RS09170	COG0101	tRNA pseudouridine synthase activity
AWC34_RS09180	COG1122	ATPase activity
AWC34_RS09185	COG1122	ATPase activity
AWC34_RS09190	COG0203	ribosomal protein L17
AWC34_RS09195	COG0202	RNA polymerase activity
AWC34_RS09205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWC34_RS09210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWC34_RS09225	COG0201	protein transport
AWC34_RS09230	COG0200	Binds to the 23S rRNA
AWC34_RS09235	COG1841	ribosomal large subunit assembly
AWC34_RS09240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWC34_RS09245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWC34_RS09250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWC34_RS09255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWC34_RS09260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWC34_RS09265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWC34_RS09270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWC34_RS09275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWC34_RS09280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWC34_RS09285	COG0255	Belongs to the universal ribosomal protein uL29 family
AWC34_RS09290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWC34_RS09295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWC34_RS09300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWC34_RS09305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWC34_RS09310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWC34_RS09315	COG0089	rRNA binding
AWC34_RS09320	COG0088	Forms part of the polypeptide exit tunnel
AWC34_RS09325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWC34_RS09330	COG0051	transcription antitermination factor activity, RNA binding
AWC34_RS09340	COG2252	PERMEase
AWC34_RS09345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWC34_RS09345	COG0551	DNA topoisomerase type I activity
AWC34_RS09355	COG4975	Glucose uptake
AWC34_RS09375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWC34_RS09380	COG2348	transferase activity, transferring amino-acyl groups
AWC34_RS09400	COG2814	Major facilitator Superfamily
AWC34_RS09410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AWC34_RS09415	COG0746	molybdenum cofactor guanylyltransferase activity
AWC34_RS09430	COG1763	Mo-molybdopterin cofactor biosynthetic process
AWC34_RS09440	COG0315	cyclic pyranopterin monophosphate synthase activity
AWC34_RS09445	COG0521	Mo-molybdopterin cofactor biosynthetic process
AWC34_RS09450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWC34_RS09455	COG1510	regulation of RNA biosynthetic process
AWC34_RS09460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AWC34_RS09465	COG4149	molybdate abc transporter
AWC34_RS09470	COG0725	ABC transporter, periplasmic molybdate-binding protein
AWC34_RS09475	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AWC34_RS09480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWC34_RS09485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AWC34_RS09490	COG1609	Transcriptional regulator
AWC34_RS09495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWC34_RS09505	COG1268	BioY protein
AWC34_RS09510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS09515	COG1960	acyl-CoA dehydrogenase activity
AWC34_RS09520	COG1126	abc transporter atp-binding protein
AWC34_RS09525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWC34_RS09530	COG0765	amino acid transport
AWC34_RS09535	COG0765	amino acid transport
AWC34_RS09560	COG3942	CHAP domain
AWC34_RS09570	COG1757	Na H antiporter
AWC34_RS09590	COG2076	Multidrug Resistance protein
AWC34_RS09595	COG2076	Multidrug Resistance protein
AWC34_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWC34_RS09625	COG3383	formate dehydrogenase (NAD+) activity
AWC34_RS09630	COG1316	TRANSCRIPTIONal
AWC34_RS09635	COG0483	inositol monophosphate 1-phosphatase activity
AWC34_RS09655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AWC34_RS09660	COG1263	PTS System
AWC34_RS09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS09670	COG1785	Belongs to the alkaline phosphatase family
AWC34_RS09675	COG1113	amino acid transport
AWC34_RS09700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWC34_RS09705	COG0385	Bile acid
AWC34_RS09715	COG1263	PTS System
AWC34_RS09715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS09735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWC34_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS09745	COG1473	amidohydrolase
AWC34_RS09750	COG0659	secondary active sulfate transmembrane transporter activity
AWC34_RS09755	COG1228	amidohydrolase
AWC34_RS09760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AWC34_RS09765	COG3314	Sporulation integral membrane protein YlbJ
AWC34_RS09770	COG0583	DNA-binding transcription factor activity
AWC34_RS09775	COG0010	Belongs to the arginase family
AWC34_RS09780	COG1266	CAAX protease self-immunity
AWC34_RS09785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AWC34_RS09790	COG2258	MOSC domain
AWC34_RS09800	COG1668	transmembrane transport
AWC34_RS09805	COG4152	abc transporter atp-binding protein
AWC34_RS09815	COG2094	Belongs to the DNA glycosylase MPG family
AWC34_RS09820	COG1757	Na H antiporter
AWC34_RS09825	COG0786	glutamate:sodium symporter activity
AWC34_RS09830	COG1304	FMN binding
AWC34_RS09860	COG2814	Major facilitator Superfamily
AWC34_RS09865	COG1566	PFAM secretion protein HlyD family protein
AWC34_RS09875	COG2814	Major facilitator Superfamily
AWC34_RS09880	COG4640	response to antibiotic
AWC34_RS09895	COG1136	(ABC) transporter
AWC34_RS09900	COG0577	efflux transmembrane transporter activity
AWC34_RS09905	COG0745	RESPONSE REGULATOR receiver
AWC34_RS09910	COG5002	protein histidine kinase activity
AWC34_RS09910	COG3850	Histidine kinase
AWC34_RS09920	COG0438	transferase activity, transferring glycosyl groups
AWC34_RS09925	COG1620	l-lactate permease
AWC34_RS09930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWC34_RS09945	COG0604	alcohol dehydrogenase
AWC34_RS09950	COG2814	Major facilitator Superfamily
AWC34_RS09960	COG0492	ferredoxin-NADP+ reductase activity
AWC34_RS09970	COG4549	nuclear export factor GLE1
AWC34_RS09980	COG0698	ribose 5-phosphate isomerase
AWC34_RS09990	COG2376	Dihydroxyacetone kinase
AWC34_RS09995	COG1063	alcohol dehydrogenase
AWC34_RS10000	COG1349	DNA-binding transcription factor activity
AWC34_RS10005	COG1288	antiporter activity
AWC34_RS10010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS10015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS10020	COG1283	sodium-dependent phosphate transmembrane transporter activity
AWC34_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS10040	COG1263	PTS System
AWC34_RS10065	COG1846	Transcriptional regulator
AWC34_RS10075	COG2223	nitrite transmembrane transporter activity
AWC34_RS10080	COG2197	response regulator
AWC34_RS10085	COG4585	Histidine kinase
AWC34_RS10095	COG2181	nitrate reductase activity
AWC34_RS10100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AWC34_RS10105	COG1140	nitrate reductase beta subunit
AWC34_RS10110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AWC34_RS10115	COG1648	precorrin-2 dehydrogenase activity
AWC34_RS10115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWC34_RS10120	COG2146	nitrite reductase [NAD(P)H] activity
AWC34_RS10125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWC34_RS10140	COG0454	-acetyltransferase
AWC34_RS10145	COG2116	formate transmembrane transporter activity
AWC34_RS10150	COG1959	2 iron, 2 sulfur cluster binding
AWC34_RS10175	COG2353	YceI-like domain
AWC34_RS10180	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWC34_RS10180	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWC34_RS10185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AWC34_RS10200	COG2814	Major facilitator Superfamily
AWC34_RS10205	COG1131	(ABC) transporter
AWC34_RS10210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWC34_RS10215	COG0588	phosphoglycerate mutase activity
AWC34_RS10220	COG1388	LysM domain
AWC34_RS10225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWC34_RS10235	COG2814	Major facilitator Superfamily
AWC34_RS10260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AWC34_RS10280	COG4187	Peptidase family M20/M25/M40
AWC34_RS10290	COG1116	anion transmembrane transporter activity
AWC34_RS10300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWC34_RS10305	COG1960	acyl-CoA dehydrogenase activity
AWC34_RS10315	COG1174	glycine betaine transport
AWC34_RS10325	COG1174	glycine betaine transport
AWC34_RS10340	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWC34_RS10345	COG3246	L-lysine catabolic process to acetate
AWC34_RS10355	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AWC34_RS10360	COG0531	amino acid
AWC34_RS10365	COG2814	Major facilitator Superfamily
AWC34_RS10370	COG0390	transport system, permease component
AWC34_RS10375	COG4619	ABC transporter
AWC34_RS10385	COG0069	glutamate synthase activity
AWC34_RS10395	COG1363	Peptidase, m42
AWC34_RS10400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AWC34_RS10410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWC34_RS10420	COG3048	D-serine ammonia-lyase activity
AWC34_RS10425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWC34_RS10430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWC34_RS10435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWC34_RS10440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWC34_RS10445	COG0131	Imidazoleglycerol-phosphate dehydratase
AWC34_RS10450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWC34_RS10455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWC34_RS10460	COG0107	imidazoleglycerol-phosphate synthase activity
AWC34_RS10470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS10485	COG4221	oxidoreductase activity
AWC34_RS10510	COG3250	beta-galactosidase activity
AWC34_RS10515	COG2211	Major facilitator Superfamily
AWC34_RS10525	COG3949	Membrane
AWC34_RS10530	COG2610	gluconate transmembrane transporter activity
AWC34_RS10540	COG1802	Transcriptional regulator
AWC34_RS10545	COG2357	RelA SpoT domain protein
AWC34_RS10550	COG4876	unkown
AWC34_RS10565	COG1289	transmembrane transporter activity
AWC34_RS10570	COG3527	Alpha-acetolactate decarboxylase
AWC34_RS10580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWC34_RS10585	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWC34_RS10595	COG3949	Membrane
AWC34_RS10600	COG0400	carboxylic ester hydrolase activity
AWC34_RS10605	COG0346	lactoylglutathione lyase activity
AWC34_RS10610	COG0346	lactoylglutathione lyase activity
AWC34_RS10615	COG1846	Transcriptional regulator
AWC34_RS10620	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS10625	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWC34_RS10635	COG1132	(ABC) transporter
AWC34_RS10640	COG1132	(ABC) transporter
AWC34_RS10650	COG2514	catechol 2,3-dioxygenase activity
AWC34_RS10655	COG0778	Nitroreductase
AWC34_RS10660	COG0561	phosphatase activity
AWC34_RS10665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWC34_RS10670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWC34_RS10680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWC34_RS10685	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AWC34_RS10690	COG3764	Sortase (surface protein transpeptidase)
AWC34_RS10720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWC34_RS10725	COG1063	alcohol dehydrogenase
AWC34_RS10730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AWC34_RS10740	COG2843	Capsule synthesis protein
AWC34_RS10750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWC34_RS10765	COG0657	acetylesterase activity
AWC34_RS10785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AWC34_RS10800	COG2190	(PTS) system
AWC34_RS10800	COG1263	PTS System
AWC34_RS10800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS10805	COG1288	antiporter activity
AWC34_RS10820	COG0028	Belongs to the TPP enzyme family
AWC34_RS10835	COG0583	DNA-binding transcription factor activity
AWC34_RS10840	COG1757	Na H antiporter
AWC34_RS10845	COG3386	PFAM SMP-30 Gluconolaconase
AWC34_RS10860	COG3425	synthase
AWC34_RS10865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWC34_RS10870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWC34_RS10885	COG2819	hydrolase of the alpha beta superfamily
AWC34_RS10895	COG1473	amidohydrolase
AWC34_RS10910	COG2409	Drug exporters of the RND superfamily
AWC34_RS10920	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS10925	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
AWC34_RS10940	COG4336	lyase activity
AWC34_RS10955	COG5505	Protein of unknown function (DUF819)
AWC34_RS10960	COG0471	metal ion transport
AWC34_RS10985	COG0577	efflux transmembrane transporter activity
AWC34_RS10985	COG1136	(ABC) transporter
AWC34_RS10990	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS10995	COG0577	efflux transmembrane transporter activity
AWC34_RS11000	COG1136	(ABC) transporter
AWC34_RS11005	COG0659	secondary active sulfate transmembrane transporter activity
AWC34_RS11010	COG2217	Heavy metal translocating P-type atpase
AWC34_RS11015	COG2608	mercury ion transmembrane transporter activity
AWC34_RS11025	COG0436	Aminotransferase
AWC34_RS11030	COG0741	lytic transglycosylase activity
AWC34_RS11045	COG3189	MarR family transcriptional regulator
AWC34_RS11050	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AWC34_RS11085	COG3001	Fructosamine kinase
AWC34_RS11090	COG0167	dihydroorotate dehydrogenase activity
AWC34_RS11100	COG0561	phosphatase activity
AWC34_RS11120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS11145	COG0747	negative chemotaxis
AWC34_RS11150	COG4413	Urea transporter
AWC34_RS11155	COG0831	urea catabolic process
AWC34_RS11160	COG0832	Belongs to the urease beta subunit family
AWC34_RS11165	COG0804	urea catabolic process
AWC34_RS11170	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AWC34_RS11175	COG0830	nickel cation binding
AWC34_RS11180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWC34_RS11185	COG0829	nickel cation binding
AWC34_RS11195	COG3949	Membrane
AWC34_RS11205	COG0626	cystathionine gamma-synthase activity
AWC34_RS11210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWC34_RS11230	COG1940	carbohydrate kinase activity
AWC34_RS11235	COG1482	cell wall glycoprotein biosynthetic process
AWC34_RS11240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS11240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWC34_RS11240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWC34_RS11245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS11245	COG3711	transcriptional antiterminator
AWC34_RS11250	COG0039	L-malate dehydrogenase activity
AWC34_RS11255	COG1464	Belongs to the NlpA lipoprotein family
AWC34_RS11260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWC34_RS11275	COG3181	Tripartite tricarboxylate transporter family receptor
AWC34_RS11285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWC34_RS11300	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWC34_RS11310	COG2814	Major facilitator Superfamily
AWC34_RS11320	COG3037	sugar-specific permease SgaT UlaA
AWC34_RS11330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWC34_RS11340	COG1447	Phosphotransferase system cellobiose-specific component IIA
AWC34_RS11355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWC34_RS11360	COG1846	Transcriptional regulator
AWC34_RS11360	COG1940	carbohydrate kinase activity
AWC34_RS11375	COG2348	transferase activity, transferring amino-acyl groups
AWC34_RS11380	COG0363	glucosamine-6-phosphate deaminase activity
AWC34_RS11385	COG2190	(PTS) system
AWC34_RS11385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWC34_RS11385	COG1263	PTS System
AWC34_RS11395	COG2814	Major facilitator Superfamily
AWC34_RS11400	COG1620	l-lactate permease
AWC34_RS11410	COG0431	NADPH-dependent FMN reductase
AWC34_RS11420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWC34_RS11425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWC34_RS11430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWC34_RS11435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWC34_RS11440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWC34_RS11445	COG2610	gluconate transmembrane transporter activity
AWC34_RS11450	COG1131	(ABC) transporter
AWC34_RS11475	COG1957	nucleoside hydrolase
AWC34_RS11480	COG2843	Capsule synthesis protein
AWC34_RS11490	COG0778	Nitroreductase
AWC34_RS11500	COG0463	Glycosyl transferase, family 2
AWC34_RS11500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AWC34_RS11515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AWC34_RS11520	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS11525	COG1510	regulation of RNA biosynthetic process
AWC34_RS11530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWC34_RS11540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWC34_RS11560	COG0531	amino acid
AWC34_RS11565	COG1012	belongs to the aldehyde dehydrogenase family
AWC34_RS11570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWC34_RS11575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWC34_RS11585	COG2807	transmembrane transport
AWC34_RS11590	COG1476	TRANSCRIPTIONal
AWC34_RS11615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWC34_RS11620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWC34_RS11620	COG0574	Belongs to the PEP-utilizing enzyme family
AWC34_RS11625	COG3835	regulator
AWC34_RS11630	COG1929	Belongs to the glycerate kinase type-1 family
AWC34_RS11640	COG3875	lactate racemase activity
AWC34_RS11645	COG1606	tRNA processing
AWC34_RS11650	COG1691	(AIR) carboxylase
AWC34_RS11655	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AWC34_RS11660	COG0673	inositol 2-dehydrogenase activity
AWC34_RS11700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS11710	COG3961	Belongs to the TPP enzyme family
AWC34_RS11715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWC34_RS11720	COG1846	Transcriptional regulator
AWC34_RS11745	COG0584	glycerophosphoryl diester phosphodiesterase
AWC34_RS11755	COG2814	Major facilitator Superfamily
AWC34_RS11765	COG0477	Major facilitator Superfamily
AWC34_RS11805	COG0579	oxidoreductase
AWC34_RS11810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AWC34_RS11815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AWC34_RS11820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWC34_RS11830	COG1115	amino acid carrier protein
AWC34_RS11855	COG1136	(ABC) transporter
AWC34_RS11860	COG0346	lactoylglutathione lyase activity
AWC34_RS11870	COG0431	NADPH-dependent FMN reductase
AWC34_RS11875	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AWC34_RS11880	COG0602	queuosine metabolic process
AWC34_RS11885	COG1328	CTP reductase activity
AWC34_RS11890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWC34_RS11895	COG2022	thiamine diphosphate biosynthetic process
AWC34_RS11905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWC34_RS11915	COG1070	Carbohydrate kinase
AWC34_RS11935	COG1511	domain protein
AWC34_RS11940	COG1846	Transcriptional regulator
AWC34_RS11940	COG1940	carbohydrate kinase activity
AWC34_RS11945	COG2115	Belongs to the xylose isomerase family
AWC34_RS11950	COG1070	Carbohydrate kinase
AWC34_RS11955	COG0477	Major facilitator Superfamily
AWC34_RS11955	COG2814	Major facilitator Superfamily
AWC34_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS11965	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWC34_RS11970	COG2610	gluconate transmembrane transporter activity
AWC34_RS11975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWC34_RS11980	COG1609	Transcriptional regulator
AWC34_RS11990	COG1131	(ABC) transporter
AWC34_RS12005	COG2160	L-arabinose isomerase activity
AWC34_RS12010	COG0235	Class ii aldolase
AWC34_RS12020	COG1609	Transcriptional regulator
AWC34_RS12025	COG1609	Transcriptional regulator
AWC34_RS12030	COG4975	Glucose uptake
AWC34_RS12055	COG1054	Belongs to the UPF0176 family
AWC34_RS12070	COG1388	LysM domain
AWC34_RS12075	COG0564	pseudouridine synthase activity
AWC34_RS12080	COG1388	LysM domain
AWC34_RS12085	COG2318	DinB family
AWC34_RS12090	COG0471	metal ion transport
AWC34_RS12100	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AWC34_RS12100	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AWC34_RS12120	COG3414	Phosphotransferase system galactitol-specific IIB component
AWC34_RS12125	COG3775	system Galactitol-specific IIC component
AWC34_RS12130	COG1063	alcohol dehydrogenase
AWC34_RS12135	COG1063	alcohol dehydrogenase
AWC34_RS12140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWC34_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
AWC34_RS12155	COG2186	Transcriptional regulator
AWC34_RS12160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWC34_RS12160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWC34_RS12170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWC34_RS12185	COG1695	Transcriptional regulator
AWC34_RS12190	COG2059	Chromate
AWC34_RS12195	COG1929	Belongs to the glycerate kinase type-1 family
AWC34_RS12205	COG0745	RESPONSE REGULATOR receiver
AWC34_RS12210	COG5002	protein histidine kinase activity
AWC34_RS12210	COG3850	Histidine kinase
AWC34_RS12225	COG0463	Glycosyl transferase, family 2
AWC34_RS12255	COG0494	nUDIX hydrolase
AWC34_RS12260	COG0556	nucleotide-excision repair
AWC34_RS12270	COG1475	DNA binding
AWC34_RS12275	COG0019	diaminopimelate decarboxylase activity
AWC34_RS12285	COG4264	IucA IucC family
AWC34_RS12290	COG4264	IucA IucC family
AWC34_RS12295	COG2814	Major facilitator Superfamily
AWC34_RS12300	COG4264	IucA IucC family
AWC34_RS12305	COG2423	ornithine cyclodeaminase activity
AWC34_RS12315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWC34_RS12320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS12325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWC34_RS12350	COG1607	acyl-coa hydrolase
AWC34_RS12355	COG0583	DNA-binding transcription factor activity
AWC34_RS12360	COG3250	beta-galactosidase activity
AWC34_RS12365	COG2211	Major facilitator Superfamily
AWC34_RS12370	COG2207	Transcriptional regulator
AWC34_RS12375	COG1942	4-Oxalocrotonate Tautomerase
AWC34_RS12395	COG3759	membrane
AWC34_RS12405	COG2130	NADP-dependent
AWC34_RS12410	COG4145	pantothenate transmembrane transporter activity
AWC34_RS12430	COG1215	transferase activity, transferring glycosyl groups
AWC34_RS12435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWC34_RS12445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWC34_RS12450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWC34_RS12500	COG0523	cobalamin synthesis protein
AWC34_RS12505	COG0281	malic enzyme
AWC34_RS12510	COG3493	citrate carrier protein
AWC34_RS12515	COG4565	transcriptional regulatory protein
AWC34_RS12520	COG3290	protein histidine kinase activity
AWC34_RS12525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AWC34_RS12530	COG1064	alcohol dehydrogenase
AWC34_RS12545	COG0702	epimerase
AWC34_RS12555	COG0789	Transcriptional regulator
AWC34_RS12560	COG4268	DNA restriction-modification system
AWC34_RS12565	COG1401	restriction endodeoxyribonuclease activity
AWC34_RS12575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWC34_RS12670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWC34_RS12675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWC34_RS12685	COG4863	YycH protein
AWC34_RS12690	COG5002	protein histidine kinase activity
AWC34_RS12695	COG0745	RESPONSE REGULATOR receiver
AWC34_RS12700	COG0477	Major facilitator Superfamily
AWC34_RS12720	COG1819	glycosyl
AWC34_RS12725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWC34_RS12730	COG0305	Participates in initiation and elongation during chromosome replication
AWC34_RS12735	COG0359	binds to the 23S rRNA
AWC34_RS12740	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AWC34_RS12750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AWC34_RS12760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWC34_RS12765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWC34_RS12770	COG2986	histidine ammonia-lyase
AWC34_RS12775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWC34_RS12780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWC34_RS12785	COG0187	DNA topoisomerase II activity
AWC34_RS12790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWC34_RS12795	COG2501	S4 domain
AWC34_RS12800	COG0592	DNA-directed DNA polymerase activity
AWC34_RS12805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AWC34_RS13235	COG1063	alcohol dehydrogenase