locus-tag	class	description
JL104_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JL104_RS00010	COG0592	DNA-directed DNA polymerase activity
JL104_RS00015	COG2501	S4 domain
JL104_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JL104_RS00025	COG0187	DNA topoisomerase II activity
JL104_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JL104_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JL104_RS00040	COG2986	histidine ammonia-lyase
JL104_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JL104_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JL104_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JL104_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JL104_RS00075	COG0359	binds to the 23S rRNA
JL104_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
JL104_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JL104_RS00090	COG1819	glycosyl
JL104_RS00110	COG0477	Major facilitator Superfamily
JL104_RS00115	COG0745	RESPONSE REGULATOR receiver
JL104_RS00120	COG5002	protein histidine kinase activity
JL104_RS00125	COG4863	YycH protein
JL104_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JL104_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JL104_RS00260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JL104_RS00265	COG0110	maltose O-acetyltransferase activity
JL104_RS00270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JL104_RS00275	COG0789	Transcriptional regulator
JL104_RS00285	COG0702	epimerase
JL104_RS00305	COG1064	alcohol dehydrogenase
JL104_RS00310	COG3711	transcriptional antiterminator
JL104_RS00315	COG1263	PTS System
JL104_RS00315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS00320	COG2723	6-phospho-beta-galactosidase activity
JL104_RS00325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JL104_RS00330	COG3290	protein histidine kinase activity
JL104_RS00335	COG4565	transcriptional regulatory protein
JL104_RS00340	COG3493	citrate carrier protein
JL104_RS00350	COG0523	cobalamin synthesis protein
JL104_RS00385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS00395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JL104_RS00400	COG1215	transferase activity, transferring glycosyl groups
JL104_RS00430	COG4145	pantothenate transmembrane transporter activity
JL104_RS00435	COG2130	NADP-dependent
JL104_RS00445	COG3759	membrane
JL104_RS00465	COG1942	4-Oxalocrotonate Tautomerase
JL104_RS00475	COG1131	(ABC) transporter
JL104_RS00480	COG0535	radical SAM domain protein
JL104_RS00495	COG2207	Transcriptional regulator
JL104_RS00500	COG2211	Major facilitator Superfamily
JL104_RS00505	COG3250	beta-galactosidase activity
JL104_RS00510	COG0583	DNA-binding transcription factor activity
JL104_RS00515	COG1607	acyl-coa hydrolase
JL104_RS00535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS00540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS00545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS00555	COG2423	ornithine cyclodeaminase activity
JL104_RS00560	COG4264	IucA IucC family
JL104_RS00565	COG2814	Major facilitator Superfamily
JL104_RS00570	COG4264	IucA IucC family
JL104_RS00575	COG4264	IucA IucC family
JL104_RS00585	COG0019	diaminopimelate decarboxylase activity
JL104_RS00590	COG1475	DNA binding
JL104_RS00600	COG0556	nucleotide-excision repair
JL104_RS00605	COG0494	nUDIX hydrolase
JL104_RS00635	COG0463	Glycosyl transferase, family 2
JL104_RS00650	COG3850	Histidine kinase
JL104_RS00650	COG5002	protein histidine kinase activity
JL104_RS00655	COG0745	RESPONSE REGULATOR receiver
JL104_RS00665	COG1929	Belongs to the glycerate kinase type-1 family
JL104_RS00670	COG2059	Chromate
JL104_RS00675	COG1695	Transcriptional regulator
JL104_RS00690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JL104_RS00700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JL104_RS00700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JL104_RS00705	COG2186	Transcriptional regulator
JL104_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS00725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JL104_RS00730	COG1063	alcohol dehydrogenase
JL104_RS00740	COG1063	alcohol dehydrogenase
JL104_RS00745	COG3775	system Galactitol-specific IIC component
JL104_RS00750	COG3414	Phosphotransferase system galactitol-specific IIB component
JL104_RS00770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JL104_RS00770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JL104_RS00780	COG0471	metal ion transport
JL104_RS00785	COG2318	DinB family
JL104_RS00790	COG1388	LysM domain
JL104_RS00795	COG0564	pseudouridine synthase activity
JL104_RS00800	COG1388	LysM domain
JL104_RS00820	COG1054	Belongs to the UPF0176 family
JL104_RS00845	COG4975	Glucose uptake
JL104_RS00850	COG1609	Transcriptional regulator
JL104_RS00855	COG1609	Transcriptional regulator
JL104_RS00865	COG0235	Class ii aldolase
JL104_RS00870	COG2160	L-arabinose isomerase activity
JL104_RS00890	COG0730	response to heat
JL104_RS00895	COG1937	Protein conserved in bacteria
JL104_RS00900	COG2210	Belongs to the sulfur carrier protein TusA family
JL104_RS00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JL104_RS00910	COG1131	(ABC) transporter
JL104_RS00920	COG2814	Major facilitator Superfamily
JL104_RS00920	COG0477	Major facilitator Superfamily
JL104_RS00925	COG1070	Carbohydrate kinase
JL104_RS00930	COG2115	Belongs to the xylose isomerase family
JL104_RS00935	COG1846	Transcriptional regulator
JL104_RS00935	COG1940	carbohydrate kinase activity
JL104_RS00940	COG1511	domain protein
JL104_RS00960	COG1070	Carbohydrate kinase
JL104_RS00980	COG2022	thiamine diphosphate biosynthetic process
JL104_RS00985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JL104_RS00995	COG0602	queuosine metabolic process
JL104_RS01000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JL104_RS01005	COG0431	NADPH-dependent FMN reductase
JL104_RS01015	COG0346	lactoylglutathione lyase activity
JL104_RS01020	COG2188	Transcriptional regulator
JL104_RS01025	COG2084	Dehydrogenase
JL104_RS01035	COG2610	gluconate transmembrane transporter activity
JL104_RS01040	COG1136	(ABC) transporter
JL104_RS01065	COG1115	amino acid carrier protein
JL104_RS01075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JL104_RS01080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JL104_RS01085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JL104_RS01090	COG0579	oxidoreductase
JL104_RS01115	COG0477	Major facilitator Superfamily
JL104_RS01125	COG2814	Major facilitator Superfamily
JL104_RS01135	COG0584	glycerophosphoryl diester phosphodiesterase
JL104_RS01160	COG1846	Transcriptional regulator
JL104_RS01170	COG3961	Belongs to the TPP enzyme family
JL104_RS01180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS01220	COG0673	inositol 2-dehydrogenase activity
JL104_RS01225	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
JL104_RS01230	COG1691	(AIR) carboxylase
JL104_RS01235	COG1606	tRNA processing
JL104_RS01240	COG3875	lactate racemase activity
JL104_RS01250	COG1929	Belongs to the glycerate kinase type-1 family
JL104_RS01255	COG3835	regulator
JL104_RS01265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JL104_RS01265	COG0574	Belongs to the PEP-utilizing enzyme family
JL104_RS01270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JL104_RS01295	COG1476	TRANSCRIPTIONal
JL104_RS01300	COG2807	transmembrane transport
JL104_RS01310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JL104_RS01315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JL104_RS01320	COG1012	belongs to the aldehyde dehydrogenase family
JL104_RS01325	COG0531	amino acid
JL104_RS01345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JL104_RS01355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JL104_RS01360	COG1510	regulation of RNA biosynthetic process
JL104_RS01365	COG1012	belongs to the aldehyde dehydrogenase family
JL104_RS01370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JL104_RS01385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS01385	COG0463	Glycosyl transferase, family 2
JL104_RS01395	COG0778	Nitroreductase
JL104_RS01405	COG2843	Capsule synthesis protein
JL104_RS01410	COG1957	nucleoside hydrolase
JL104_RS01435	COG1131	(ABC) transporter
JL104_RS01440	COG2610	gluconate transmembrane transporter activity
JL104_RS01445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JL104_RS01450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JL104_RS01455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JL104_RS01460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JL104_RS01465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JL104_RS01475	COG0431	NADPH-dependent FMN reductase
JL104_RS01485	COG1620	l-lactate permease
JL104_RS01490	COG2814	Major facilitator Superfamily
JL104_RS01500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS01500	COG2190	(PTS) system
JL104_RS01500	COG1263	PTS System
JL104_RS01505	COG0363	glucosamine-6-phosphate deaminase activity
JL104_RS01510	COG2348	transferase activity, transferring amino-acyl groups
JL104_RS01515	COG1940	carbohydrate kinase activity
JL104_RS01515	COG1846	Transcriptional regulator
JL104_RS01520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JL104_RS01535	COG1447	Phosphotransferase system cellobiose-specific component IIA
JL104_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JL104_RS01555	COG3037	sugar-specific permease SgaT UlaA
JL104_RS01565	COG0438	transferase activity, transferring glycosyl groups
JL104_RS01570	COG2814	Major facilitator Superfamily
JL104_RS01580	COG0179	Fumarylacetoacetate (FAA) hydrolase
JL104_RS01595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JL104_RS01610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JL104_RS01615	COG1464	Belongs to the NlpA lipoprotein family
JL104_RS01620	COG0039	L-malate dehydrogenase activity
JL104_RS01630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JL104_RS01630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JL104_RS01630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JL104_RS01635	COG1482	cell wall glycoprotein biosynthetic process
JL104_RS01640	COG1940	carbohydrate kinase activity
JL104_RS01660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JL104_RS01665	COG0626	cystathionine gamma-synthase activity
JL104_RS01675	COG3949	Membrane
JL104_RS01685	COG0829	nickel cation binding
JL104_RS01690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JL104_RS01695	COG0830	nickel cation binding
JL104_RS01710	COG0747	negative chemotaxis
JL104_RS01735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS01755	COG0561	phosphatase activity
JL104_RS01765	COG0167	dihydroorotate dehydrogenase activity
JL104_RS01770	COG3001	Fructosamine kinase
JL104_RS01805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JL104_RS01810	COG3189	MarR family transcriptional regulator
JL104_RS01825	COG1388	LysM domain
JL104_RS01830	COG0436	Aminotransferase
JL104_RS01840	COG2608	mercury ion transmembrane transporter activity
JL104_RS01845	COG2217	Heavy metal translocating P-type atpase
JL104_RS01850	COG0659	secondary active sulfate transmembrane transporter activity
JL104_RS01855	COG1136	(ABC) transporter
JL104_RS01860	COG0577	efflux transmembrane transporter activity
JL104_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS01870	COG1136	(ABC) transporter
JL104_RS01870	COG0577	efflux transmembrane transporter activity
JL104_RS01895	COG0471	metal ion transport
JL104_RS01900	COG5505	Protein of unknown function (DUF819)
JL104_RS01915	COG4336	lyase activity
JL104_RS01930	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
JL104_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
JL104_RS01945	COG2409	Drug exporters of the RND superfamily
JL104_RS01960	COG1473	amidohydrolase
JL104_RS01970	COG2819	hydrolase of the alpha beta superfamily
JL104_RS01985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JL104_RS01990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JL104_RS01995	COG3425	synthase
JL104_RS02010	COG3386	PFAM SMP-30 Gluconolaconase
JL104_RS02015	COG1757	Na H antiporter
JL104_RS02020	COG0583	DNA-binding transcription factor activity
JL104_RS02025	COG1380	Effector of murein hydrolase LrgA
JL104_RS02035	COG0028	Belongs to the TPP enzyme family
JL104_RS02050	COG1288	antiporter activity
JL104_RS02055	COG2190	(PTS) system
JL104_RS02055	COG1263	PTS System
JL104_RS02055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS02070	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JL104_RS02090	COG0657	acetylesterase activity
JL104_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JL104_RS02115	COG2843	Capsule synthesis protein
JL104_RS02130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JL104_RS02135	COG1063	alcohol dehydrogenase
JL104_RS02140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS02165	COG3764	Sortase (surface protein transpeptidase)
JL104_RS02170	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JL104_RS02175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JL104_RS02185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JL104_RS02190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JL104_RS02195	COG0561	phosphatase activity
JL104_RS02200	COG0778	Nitroreductase
JL104_RS02205	COG2514	catechol 2,3-dioxygenase activity
JL104_RS02215	COG1132	(ABC) transporter
JL104_RS02220	COG1132	(ABC) transporter
JL104_RS02230	COG0803	Belongs to the bacterial solute-binding protein 9 family
JL104_RS02235	COG1012	belongs to the aldehyde dehydrogenase family
JL104_RS02240	COG1846	Transcriptional regulator
JL104_RS02245	COG0346	lactoylglutathione lyase activity
JL104_RS02250	COG0346	lactoylglutathione lyase activity
JL104_RS02255	COG0400	carboxylic ester hydrolase activity
JL104_RS02260	COG3949	Membrane
JL104_RS02270	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JL104_RS02275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JL104_RS02285	COG3527	Alpha-acetolactate decarboxylase
JL104_RS02290	COG1289	transmembrane transporter activity
JL104_RS02305	COG4876	unkown
JL104_RS02310	COG2357	RelA SpoT domain protein
JL104_RS02315	COG1802	Transcriptional regulator
JL104_RS02325	COG2610	gluconate transmembrane transporter activity
JL104_RS02330	COG3949	Membrane
JL104_RS02340	COG2211	Major facilitator Superfamily
JL104_RS02370	COG4221	oxidoreductase activity
JL104_RS02385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS02395	COG0107	imidazoleglycerol-phosphate synthase activity
JL104_RS02400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JL104_RS02405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JL104_RS02410	COG0131	Imidazoleglycerol-phosphate dehydratase
JL104_RS02415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JL104_RS02420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JL104_RS02425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JL104_RS02430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JL104_RS02435	COG3048	D-serine ammonia-lyase activity
JL104_RS02445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JL104_RS02455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JL104_RS02460	COG1363	Peptidase, m42
JL104_RS02470	COG0069	glutamate synthase activity
JL104_RS02480	COG4619	ABC transporter
JL104_RS02485	COG0390	transport system, permease component
JL104_RS02490	COG2814	Major facilitator Superfamily
JL104_RS02495	COG0531	amino acid
JL104_RS02500	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
JL104_RS02510	COG3246	L-lysine catabolic process to acetate
JL104_RS02515	COG1250	3-hydroxyacyl-CoA dehydrogenase
JL104_RS02530	COG1174	glycine betaine transport
JL104_RS02540	COG1174	glycine betaine transport
JL104_RS02550	COG1960	acyl-CoA dehydrogenase activity
JL104_RS02555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JL104_RS02565	COG1116	anion transmembrane transporter activity
JL104_RS02575	COG4187	Peptidase family M20/M25/M40
JL104_RS02595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JL104_RS02620	COG2814	Major facilitator Superfamily
JL104_RS02630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JL104_RS02635	COG1388	LysM domain
JL104_RS02640	COG0588	phosphoglycerate mutase activity
JL104_RS02650	COG1131	(ABC) transporter
JL104_RS02660	COG2814	Major facilitator Superfamily
JL104_RS02675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JL104_RS02680	COG0803	Belongs to the bacterial solute-binding protein 9 family
JL104_RS02680	COG3443	Belongs to the bacterial solute-binding protein 9 family
JL104_RS02685	COG2353	YceI-like domain
JL104_RS02715	COG2723	6-phospho-beta-galactosidase activity
JL104_RS02725	COG2188	Transcriptional regulator
JL104_RS02730	COG1959	2 iron, 2 sulfur cluster binding
JL104_RS02735	COG2116	formate transmembrane transporter activity
JL104_RS02740	COG0454	-acetyltransferase
JL104_RS02755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JL104_RS02760	COG2146	nitrite reductase [NAD(P)H] activity
JL104_RS02765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JL104_RS02765	COG1648	precorrin-2 dehydrogenase activity
JL104_RS02770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JL104_RS02775	COG1140	nitrate reductase beta subunit
JL104_RS02780	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JL104_RS02785	COG2181	nitrate reductase activity
JL104_RS02795	COG4585	Histidine kinase
JL104_RS02800	COG2197	response regulator
JL104_RS02805	COG2223	nitrite transmembrane transporter activity
JL104_RS02815	COG1846	Transcriptional regulator
JL104_RS02840	COG1263	PTS System
JL104_RS02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS02860	COG1283	sodium-dependent phosphate transmembrane transporter activity
JL104_RS02865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS02875	COG1288	antiporter activity
JL104_RS02880	COG1349	DNA-binding transcription factor activity
JL104_RS02885	COG1063	alcohol dehydrogenase
JL104_RS02890	COG2376	Dihydroxyacetone kinase
JL104_RS02900	COG0698	ribose 5-phosphate isomerase
JL104_RS02910	COG4549	nuclear export factor GLE1
JL104_RS02920	COG0492	ferredoxin-NADP+ reductase activity
JL104_RS02930	COG2814	Major facilitator Superfamily
JL104_RS02935	COG0604	alcohol dehydrogenase
JL104_RS02950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS02955	COG1620	l-lactate permease
JL104_RS02960	COG0438	transferase activity, transferring glycosyl groups
JL104_RS02970	COG5002	protein histidine kinase activity
JL104_RS02970	COG3850	Histidine kinase
JL104_RS02975	COG0745	RESPONSE REGULATOR receiver
JL104_RS02980	COG0577	efflux transmembrane transporter activity
JL104_RS02985	COG1136	(ABC) transporter
JL104_RS03000	COG4640	response to antibiotic
JL104_RS03005	COG2814	Major facilitator Superfamily
JL104_RS03015	COG1566	PFAM secretion protein HlyD family protein
JL104_RS03020	COG2814	Major facilitator Superfamily
JL104_RS03050	COG1304	FMN binding
JL104_RS03055	COG0786	glutamate:sodium symporter activity
JL104_RS03060	COG1757	Na H antiporter
JL104_RS03065	COG2094	Belongs to the DNA glycosylase MPG family
JL104_RS03075	COG4152	abc transporter atp-binding protein
JL104_RS03080	COG1668	transmembrane transport
JL104_RS03090	COG2258	MOSC domain
JL104_RS03095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JL104_RS03100	COG1266	CAAX protease self-immunity
JL104_RS03105	COG0010	Belongs to the arginase family
JL104_RS03110	COG0583	DNA-binding transcription factor activity
JL104_RS03120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JL104_RS03125	COG1228	amidohydrolase
JL104_RS03130	COG0659	secondary active sulfate transmembrane transporter activity
JL104_RS03135	COG1473	amidohydrolase
JL104_RS03145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JL104_RS03165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS03165	COG1263	PTS System
JL104_RS03175	COG0385	Bile acid
JL104_RS03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JL104_RS03205	COG1113	amino acid transport
JL104_RS03210	COG1785	Belongs to the alkaline phosphatase family
JL104_RS03220	COG1263	PTS System
JL104_RS03220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS03225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JL104_RS03245	COG0483	inositol monophosphate 1-phosphatase activity
JL104_RS03250	COG1316	TRANSCRIPTIONal
JL104_RS03255	COG3383	formate dehydrogenase (NAD+) activity
JL104_RS03280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JL104_RS03285	COG2076	Multidrug Resistance protein
JL104_RS03290	COG2076	Multidrug Resistance protein
JL104_RS03310	COG1757	Na H antiporter
JL104_RS03320	COG3942	CHAP domain
JL104_RS03345	COG0765	amino acid transport
JL104_RS03350	COG0765	amino acid transport
JL104_RS03355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JL104_RS03360	COG1126	abc transporter atp-binding protein
JL104_RS03365	COG1960	acyl-CoA dehydrogenase activity
JL104_RS03370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS03375	COG1268	BioY protein
JL104_RS03390	COG1609	Transcriptional regulator
JL104_RS03395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JL104_RS03400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JL104_RS03405	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JL104_RS03410	COG0725	ABC transporter, periplasmic molybdate-binding protein
JL104_RS03415	COG4149	molybdate abc transporter
JL104_RS03420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JL104_RS03425	COG1510	regulation of RNA biosynthetic process
JL104_RS03430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JL104_RS03440	COG0315	cyclic pyranopterin monophosphate synthase activity
JL104_RS03450	COG1763	Mo-molybdopterin cofactor biosynthetic process
JL104_RS03465	COG0746	molybdenum cofactor guanylyltransferase activity
JL104_RS03470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JL104_RS03480	COG2814	Major facilitator Superfamily
JL104_RS03495	COG2348	transferase activity, transferring amino-acyl groups
JL104_RS03500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JL104_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS03525	COG4975	Glucose uptake
JL104_RS03535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JL104_RS03535	COG0551	DNA topoisomerase type I activity
JL104_RS03540	COG2252	PERMEase
JL104_RS03550	COG0051	transcription antitermination factor activity, RNA binding
JL104_RS03555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JL104_RS03560	COG0088	Forms part of the polypeptide exit tunnel
JL104_RS03565	COG0089	rRNA binding
JL104_RS03570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JL104_RS03575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JL104_RS03580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JL104_RS03585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JL104_RS03590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JL104_RS03595	COG0255	Belongs to the universal ribosomal protein uL29 family
JL104_RS03600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JL104_RS03605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JL104_RS03610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JL104_RS03615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JL104_RS03620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JL104_RS03625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JL104_RS03630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JL104_RS03635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JL104_RS03640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JL104_RS03645	COG1841	ribosomal large subunit assembly
JL104_RS03650	COG0200	Binds to the 23S rRNA
JL104_RS03655	COG0201	protein transport
JL104_RS03670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JL104_RS03675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JL104_RS03685	COG0202	RNA polymerase activity
JL104_RS03690	COG0203	ribosomal protein L17
JL104_RS03695	COG1122	ATPase activity
JL104_RS03700	COG1122	ATPase activity
JL104_RS03710	COG0101	tRNA pseudouridine synthase activity
JL104_RS03715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JL104_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS03735	COG2130	NADP-dependent
JL104_RS03740	COG0604	alcohol dehydrogenase
JL104_RS03745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JL104_RS03760	COG1302	Protein conserved in bacteria
JL104_RS03765	COG4264	IucA IucC family
JL104_RS03770	COG4264	IucA IucC family
JL104_RS03775	COG3457	Alanine racemase
JL104_RS03780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JL104_RS03785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS03790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS03795	COG3314	Sporulation integral membrane protein YlbJ
JL104_RS03800	COG2329	Antibiotic biosynthesis monooxygenase
JL104_RS03810	COG1988	membrane-bound metal-dependent
JL104_RS03815	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JL104_RS03820	COG1272	protein, Hemolysin III
JL104_RS03835	COG0489	protein tyrosine kinase activity
JL104_RS03890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JL104_RS03900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JL104_RS03905	COG0246	Mannitol dehydrogenase
JL104_RS03915	COG3711	transcriptional antiterminator
JL104_RS03940	COG1119	ATPase activity
JL104_RS03965	COG0640	Transcriptional regulator
JL104_RS03970	COG0702	epimerase
JL104_RS03975	COG2186	Transcriptional regulator
JL104_RS03980	COG1482	cell wall glycoprotein biosynthetic process
JL104_RS03990	COG2855	membrane
JL104_RS04005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JL104_RS04010	COG0783	Belongs to the Dps family
JL104_RS04015	COG0813	purine-nucleoside phosphorylase activity
JL104_RS04020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JL104_RS04025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JL104_RS04030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JL104_RS04040	COG1854	S-ribosylhomocysteine lyase activity
JL104_RS04060	COG5146	pantothenate kinase activity
JL104_RS04070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JL104_RS04075	COG3343	RNA polymerase activity
JL104_RS04080	COG0504	CTP synthase activity
JL104_RS04085	COG0191	fructose-bisphosphate aldolase activity
JL104_RS04090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JL104_RS04100	COG1012	belongs to the aldehyde dehydrogenase family
JL104_RS04105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JL104_RS04110	COG0254	rRNA binding
JL104_RS04115	COG1435	thymidine kinase activity
JL104_RS04120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JL104_RS04125	COG2890	protein-(glutamine-N5) methyltransferase activity
JL104_RS04130	COG0009	L-threonylcarbamoyladenylate synthase
JL104_RS04135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JL104_RS04140	COG4475	Protein of unknown function (DUF436)
JL104_RS04145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JL104_RS04150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JL104_RS04155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JL104_RS04165	COG0356	it plays a direct role in the translocation of protons across the membrane
JL104_RS04170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JL104_RS04175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JL104_RS04180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JL104_RS04185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JL104_RS04190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JL104_RS04195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JL104_RS04200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JL104_RS04210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JL104_RS04215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JL104_RS04225	COG0629	single-stranded DNA binding
JL104_RS04230	COG1388	LysM domain
JL104_RS04235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JL104_RS04245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JL104_RS04250	COG0352	thiamine-phosphate diphosphorylase activity
JL104_RS04255	COG0706	membrane insertase activity
JL104_RS04260	COG1418	mRNA catabolic process
JL104_RS04270	COG1937	Protein conserved in bacteria
JL104_RS04285	COG0772	Belongs to the SEDS family
JL104_RS04290	COG1181	Belongs to the D-alanine--D-alanine ligase family
JL104_RS04295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JL104_RS04300	COG0513	Belongs to the DEAD box helicase family
JL104_RS04310	COG3428	Bacterial PH domain
JL104_RS04320	COG0736	holo-[acyl-carrier-protein] synthase activity
JL104_RS04325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JL104_RS04335	COG2337	Toxic component of a toxin-antitoxin (TA) module
JL104_RS04340	COG2208	phosphoserine phosphatase activity
JL104_RS04355	COG1191	sigma factor activity
JL104_RS04360	COG2183	response to ionizing radiation
JL104_RS04365	COG3091	SprT-like family
JL104_RS04395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JL104_RS04400	COG0066	3-isopropylmalate dehydratase activity
JL104_RS04405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JL104_RS04410	COG0473	3-isopropylmalate dehydrogenase activity
JL104_RS04415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JL104_RS04420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JL104_RS04425	COG0440	acetolactate synthase activity
JL104_RS04430	COG0028	Belongs to the TPP enzyme family
JL104_RS04435	COG0129	dihydroxy-acid dehydratase activity
JL104_RS04440	COG0802	atpase or kinase
JL104_RS04445	COG1214	PFAM Peptidase M22, glycoprotease
JL104_RS04450	COG0456	acetyltransferase
JL104_RS04455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JL104_RS04465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JL104_RS04470	COG0488	(ABC) transporter
JL104_RS04475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JL104_RS04480	COG2391	methyltransferase activity
JL104_RS04485	COG0425	Belongs to the sulfur carrier protein TusA family
JL104_RS04490	COG1609	Transcriptional regulator
JL104_RS04495	COG1621	beta-fructofuranosidase activity
JL104_RS04505	COG3279	Response regulator of the LytR AlgR family
JL104_RS04510	COG3290	protein histidine kinase activity
JL104_RS04520	COG4512	PFAM Accessory gene regulator B
JL104_RS04545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JL104_RS04550	COG0459	protein refolding
JL104_RS04575	COG1725	Transcriptional regulator
JL104_RS04590	COG1131	(ABC) transporter
JL104_RS04625	COG0561	phosphatase activity
JL104_RS04660	COG2706	6-phosphogluconolactonase activity
JL104_RS04670	COG1227	inorganic diphosphatase activity
JL104_RS04675	COG1335	isochorismatase
JL104_RS04685	COG0471	metal ion transport
JL104_RS04690	COG0077	Prephenate dehydratase
JL104_RS04700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JL104_RS04705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JL104_RS04710	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JL104_RS04720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JL104_RS04725	COG4496	protein, YerC YecD
JL104_RS04735	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JL104_RS04740	COG0210	DNA helicase
JL104_RS04745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JL104_RS04750	COG4851	CamS sex pheromone cAM373 precursor
JL104_RS04755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JL104_RS04760	COG0154	amidase activity
JL104_RS04765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JL104_RS04770	COG1597	lipid kinase activity
JL104_RS04775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JL104_RS04785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JL104_RS04795	COG1528	Iron-storage protein
JL104_RS04810	COG4129	membrane
JL104_RS04815	COG0024	Methionine aminopeptidase
JL104_RS04830	COG4585	Histidine kinase
JL104_RS04835	COG2197	response regulator
JL104_RS04840	COG1295	ribonuclease BN
JL104_RS04850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JL104_RS04855	COG4840	Belongs to the UPF0435 family
JL104_RS04860	COG2309	aminopeptidase activity
JL104_RS04865	COG1607	acyl-coa hydrolase
JL104_RS04875	COG0693	protein deglycase activity
JL104_RS04880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JL104_RS04885	COG2137	regulation of response to DNA damage stimulus
JL104_RS04905	COG1988	membrane-bound metal-dependent
JL104_RS04910	COG1194	a g-specific adenine glycosylase
JL104_RS04915	COG3557	Belongs to the UPF0374 family
JL104_RS04925	COG4129	membrane
JL104_RS04930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JL104_RS04935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JL104_RS04940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JL104_RS04945	COG0735	belongs to the Fur family
JL104_RS05105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JL104_RS05225	COG0756	dUTP diphosphatase activity
JL104_RS05250	COG1780	Probably involved in ribonucleotide reductase function
JL104_RS05260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JL104_RS05270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JL104_RS05290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JL104_RS05520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS05520	COG0463	Glycosyl transferase, family 2
JL104_RS05545	COG0765	amino acid transport
JL104_RS05550	COG1126	abc transporter atp-binding protein
JL104_RS05555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JL104_RS05565	COG0363	glucosamine-6-phosphate deaminase activity
JL104_RS05580	COG0114	fumarate hydratase activity
JL104_RS05585	COG0564	pseudouridine synthase activity
JL104_RS05590	COG4585	Histidine kinase
JL104_RS05590	COG2203	Gaf domain
JL104_RS05595	COG2197	response regulator
JL104_RS05600	COG1301	dicarboxylic acid transport
JL104_RS05615	COG0788	formyltetrahydrofolate deformylase activity
JL104_RS05625	COG4399	Belongs to the UPF0754 family
JL104_RS05630	COG3679	Belongs to the UPF0342 family
JL104_RS05635	COG0420	3'-5' exonuclease activity
JL104_RS05640	COG4717	serine-type aminopeptidase activity
JL104_RS05645	COG3481	metal-dependent phosphohydrolase, HD sub domain
JL104_RS05650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JL104_RS05665	COG0537	adenosine 5'-monophosphoramidase activity
JL104_RS05670	COG1131	(ABC) transporter
JL104_RS05675	COG4473	ABC transporter
JL104_RS05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JL104_RS05690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JL104_RS05695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JL104_RS05700	COG3545	Serine hydrolase
JL104_RS05745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JL104_RS05775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JL104_RS05785	COG1506	peptidase
JL104_RS05790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JL104_RS05795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JL104_RS05805	COG0656	L-ascorbic acid biosynthetic process
JL104_RS05810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JL104_RS05815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JL104_RS05825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JL104_RS05855	COG3266	domain, Protein
JL104_RS05855	COG4193	domain, Protein
JL104_RS05855	COG5632	N-Acetylmuramoyl-L-alanine amidase
JL104_RS05870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JL104_RS05870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JL104_RS05875	COG0307	riboflavin synthase, alpha
JL104_RS05880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JL104_RS05880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JL104_RS05885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JL104_RS05890	COG0506	proline dehydrogenase activity
JL104_RS05895	COG2267	carboxylic ester hydrolase activity
JL104_RS05900	COG0039	L-malate dehydrogenase activity
JL104_RS05910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JL104_RS05915	COG1242	4 iron, 4 sulfur cluster binding
JL104_RS05920	COG2814	Major facilitator Superfamily
JL104_RS05925	COG0495	leucyl-tRNA aminoacylation
JL104_RS05935	COG2081	HI0933 family
JL104_RS05940	COG2244	polysaccharide biosynthetic process
JL104_RS05945	COG1187	pseudouridine synthase activity
JL104_RS05955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JL104_RS05965	COG0510	thiamine kinase activity
JL104_RS05970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JL104_RS05975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JL104_RS05980	COG5584	Small secreted protein
JL104_RS05985	COG1363	Peptidase, m42
JL104_RS05990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JL104_RS05995	COG4848	Belongs to the UPF0354 family
JL104_RS06000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JL104_RS06005	COG1674	ftsk spoiiie
JL104_RS06010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JL104_RS06015	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JL104_RS06025	COG1605	Chorismate mutase
JL104_RS06025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JL104_RS06030	COG1609	Transcriptional regulator
JL104_RS06035	COG0123	including yeast histone deacetylase and acetoin utilization protein
JL104_RS06040	COG0454	-acetyltransferase
JL104_RS06045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JL104_RS06060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JL104_RS06065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JL104_RS06070	COG0204	Acyl-transferase
JL104_RS06075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS06075	COG1263	PTS System
JL104_RS06085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JL104_RS06090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JL104_RS06095	COG1764	response to oxidative stress
JL104_RS06100	COG0584	glycerophosphoryl diester phosphodiesterase
JL104_RS06110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JL104_RS06115	COG1956	GAF domain-containing protein
JL104_RS06120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JL104_RS06125	COG1104	cysteine desulfurase activity
JL104_RS06130	COG0301	tRNA thio-modification
JL104_RS06140	COG0616	signal peptide processing
JL104_RS06145	COG1714	RDD family
JL104_RS06150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JL104_RS06155	COG0827	DNA restriction-modification system
JL104_RS06160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JL104_RS06170	COG0589	response to stress
JL104_RS06175	COG0686	Belongs to the AlaDH PNT family
JL104_RS06180	COG3142	Participates in the control of copper homeostasis
JL104_RS06185	COG0006	proline dipeptidase activity
JL104_RS06190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JL104_RS06200	COG4109	DRTGG domain
JL104_RS06205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JL104_RS06210	COG0587	DNA-directed DNA polymerase activity
JL104_RS06215	COG0281	malic enzyme
JL104_RS06220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JL104_RS06225	COG0825	malonyl-CoA metabolic process
JL104_RS06230	COG0205	6-phosphofructokinase activity
JL104_RS06235	COG0469	pyruvate kinase activity
JL104_RS06240	COG1113	amino acid transport
JL104_RS06245	COG0372	Belongs to the citrate synthase family
JL104_RS06250	COG0538	isocitrate dehydrogenase activity
JL104_RS06255	COG0745	RESPONSE REGULATOR receiver
JL104_RS06260	COG5002	protein histidine kinase activity
JL104_RS06265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JL104_RS06265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JL104_RS06270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JL104_RS06275	COG0237	dephospho-CoA kinase activity
JL104_RS06280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JL104_RS06285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JL104_RS06295	COG1484	DNA-dependent DNA replication
JL104_RS06300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JL104_RS06305	COG0833	amino acid
JL104_RS06310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JL104_RS06315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JL104_RS06320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JL104_RS06325	COG4112	unkown
JL104_RS06335	COG0544	peptidyl-prolyl cis-trans isomerase activity
JL104_RS06340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JL104_RS06345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JL104_RS06350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JL104_RS06355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JL104_RS06360	COG0181	hydroxymethylbilane synthase activity
JL104_RS06365	COG1587	Uroporphyrinogen-III synthase
JL104_RS06370	COG0113	porphobilinogen synthase activity
JL104_RS06375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JL104_RS06380	COG3180	Ammonia monooxygenase
JL104_RS06385	COG2818	Glycosylase
JL104_RS06390	COG0525	valine-tRNA ligase activity
JL104_RS06395	COG0285	dihydrofolate synthase activity
JL104_RS06410	COG2003	Belongs to the UPF0758 family
JL104_RS06465	COG2868	ribosomal protein
JL104_RS06470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JL104_RS06475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JL104_RS06480	COG4492	Belongs to the UPF0735 family
JL104_RS06485	COG0632	four-way junction helicase activity
JL104_RS06490	COG2255	four-way junction helicase activity
JL104_RS06495	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JL104_RS06500	COG0343	queuine tRNA-ribosyltransferase activity
JL104_RS06505	COG1862	Preprotein translocase
JL104_RS06510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JL104_RS06510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JL104_RS06515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JL104_RS06515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JL104_RS06525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JL104_RS06530	COG1490	D-aminoacyl-tRNA deacylase activity
JL104_RS06535	COG0860	N-Acetylmuramoyl-L-alanine amidase
JL104_RS06540	COG0124	histidyl-tRNA synthetase
JL104_RS06545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JL104_RS06555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JL104_RS06560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JL104_RS06565	COG1959	2 iron, 2 sulfur cluster binding
JL104_RS06570	COG3237	CsbD-like
JL104_RS06580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS06585	COG0488	(ABC) transporter
JL104_RS06590	COG1104	cysteine desulfurase activity
JL104_RS06595	COG0482	sulfurtransferase activity
JL104_RS06605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JL104_RS06610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JL104_RS06615	COG4472	Bacterial protein of unknown function (DUF965)
JL104_RS06620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JL104_RS06625	COG3906	Belongs to the UPF0473 family
JL104_RS06630	COG4122	O-methyltransferase activity
JL104_RS06635	COG0826	peptidase U32
JL104_RS06640	COG0826	peptidase U32
JL104_RS06645	COG0572	uridine kinase
JL104_RS06650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JL104_RS06655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JL104_RS06660	COG1984	allophanate hydrolase subunit 2
JL104_RS06670	COG0439	Biotin carboxylase
JL104_RS06675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JL104_RS06680	COG1914	H( )-stimulated, divalent metal cation uptake system
JL104_RS06685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JL104_RS06690	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JL104_RS06695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JL104_RS06700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JL104_RS06705	COG1534	Rna-binding protein
JL104_RS06710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JL104_RS06715	COG1713	HD superfamily hydrolase involved in NAD metabolism
JL104_RS06720	COG0799	negative regulation of ribosome biogenesis
JL104_RS06725	COG2226	methyltransferase
JL104_RS06730	COG1555	photosystem II stabilization
JL104_RS06730	COG1596	polysaccharide export
JL104_RS06735	COG2131	deaminase
JL104_RS06740	COG0658	competence protein
JL104_RS06740	COG2333	competence protein COMEC
JL104_RS06745	COG1466	dna polymerase III delta subunit
JL104_RS06750	COG0268	Binds directly to 16S ribosomal RNA
JL104_RS06755	COG0481	GTPase activity
JL104_RS06760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JL104_RS06765	COG1420	regulation of RNA biosynthetic process
JL104_RS06770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JL104_RS06775	COG0443	Heat shock 70 kDa protein
JL104_RS06780	COG0484	heat shock protein binding
JL104_RS06785	COG2264	protein methyltransferase activity
JL104_RS06790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JL104_RS06795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JL104_RS06805	COG4864	UPF0365 protein
JL104_RS06815	COG1702	phosphate starvation-inducible protein PhoH
JL104_RS06820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JL104_RS06825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JL104_RS06835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JL104_RS06840	COG1381	Involved in DNA repair and RecF pathway recombination
JL104_RS06845	COG0423	glycine-tRNA ligase activity
JL104_RS06850	COG0517	IMP dehydrogenase activity
JL104_RS06855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JL104_RS06865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JL104_RS06870	COG2384	SAM-dependent methyltransferase
JL104_RS06875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JL104_RS06880	COG0513	Belongs to the DEAD box helicase family
JL104_RS06885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JL104_RS06890	COG1121	(ABC) transporter
JL104_RS06895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JL104_RS06905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JL104_RS06910	COG0768	penicillin binding
JL104_RS06915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JL104_RS06920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JL104_RS06930	COG4483	Protein conserved in bacteria
JL104_RS06935	COG1940	carbohydrate kinase activity
JL104_RS06940	COG0011	TIGRFAM Protein of
JL104_RS06945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JL104_RS06950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JL104_RS06960	COG4537	Required for transformation and DNA binding
JL104_RS06980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JL104_RS06985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JL104_RS06990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JL104_RS06995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JL104_RS07000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JL104_RS07005	COG0095	Lipoate-protein ligase
JL104_RS07020	COG0006	proline dipeptidase activity
JL104_RS07025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JL104_RS07030	COG0511	ligase activity, forming carbon-carbon bonds
JL104_RS07035	COG0439	Biotin carboxylase
JL104_RS07040	COG1302	Protein conserved in bacteria
JL104_RS07045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JL104_RS07050	COG1570	exodeoxyribonuclease VII activity
JL104_RS07055	COG1722	exodeoxyribonuclease VII activity
JL104_RS07065	COG1438	arginine binding
JL104_RS07070	COG0497	DNA recombination
JL104_RS07075	COG0280	phosphate acetyltransferase
JL104_RS07085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JL104_RS07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JL104_RS07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
JL104_RS07110	COG4129	membrane
JL104_RS07120	COG2195	Cleaves the N-terminal amino acid of tripeptides
JL104_RS07130	COG1609	Transcriptional regulator
JL104_RS07135	COG0366	Alpha amylase catalytic
JL104_RS07145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JL104_RS07150	COG1234	tRNA 3'-trailer cleavage
JL104_RS07155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JL104_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS07165	COG0667	Aldo Keto reductase
JL104_RS07170	COG0494	nUDIX hydrolase
JL104_RS07175	COG0735	belongs to the Fur family
JL104_RS07180	COG4974	Belongs to the 'phage' integrase family
JL104_RS07190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JL104_RS07195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JL104_RS07200	COG1187	pseudouridine synthase activity
JL104_RS07205	COG0745	RESPONSE REGULATOR receiver
JL104_RS07220	COG1141	Ferredoxin
JL104_RS07230	COG0514	ATP-dependent DNA helicase (RecQ)
JL104_RS07235	COG1388	LysM domain
JL104_RS07235	COG1388	LysM domain
JL104_RS07240	COG0492	ferredoxin-NADP+ reductase activity
JL104_RS07250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JL104_RS07255	COG0539	negative regulation of cytoplasmic translation
JL104_RS07260	COG1160	GTP binding
JL104_RS07265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JL104_RS07280	COG2226	methyltransferase
JL104_RS07285	COG0142	geranyltranstransferase activity
JL104_RS07290	COG0105	UTP biosynthetic process
JL104_RS07295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JL104_RS07305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JL104_RS07315	COG5582	Belongs to the UPF0302 family
JL104_RS07320	COG4347	Protein of unknown function (DUF1405)
JL104_RS07325	COG2738	Putative neutral zinc metallopeptidase
JL104_RS07330	COG1694	Mazg nucleotide pyrophosphohydrolase
JL104_RS07335	COG0438	transferase activity, transferring glycosyl groups
JL104_RS07340	COG0617	tRNA 3'-terminal CCA addition
JL104_RS07350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JL104_RS07350	COG1199	ATP-dependent helicase activity
JL104_RS07355	COG0017	Asparaginyl-tRNA synthetase
JL104_RS07360	COG3935	DnaD domain protein
JL104_RS07365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JL104_RS07375	COG4499	WXG100 protein secretion system (Wss), protein YukC
JL104_RS07375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JL104_RS07380	COG3331	DNA recombination
JL104_RS07390	COG4474	Belongs to the UPF0398 family
JL104_RS07405	COG0116	Belongs to the methyltransferase superfamily
JL104_RS07410	COG2962	Rard protein
JL104_RS07420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JL104_RS07425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JL104_RS07430	COG0328	RNA-DNA hybrid ribonuclease activity
JL104_RS07440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JL104_RS07450	COG1413	lyase activity
JL104_RS07455	COG1413	lyase activity
JL104_RS07465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JL104_RS07485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JL104_RS07495	COG4479	Belongs to the UPF0346 family
JL104_RS07500	COG0793	Belongs to the peptidase S41A family
JL104_RS07510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JL104_RS07515	COG0671	phosphoesterase, PA-phosphatase related
JL104_RS07520	COG0745	RESPONSE REGULATOR receiver
JL104_RS07525	COG5002	protein histidine kinase activity
JL104_RS07530	COG0567	Dehydrogenase, E1 component
JL104_RS07535	COG0508	dehydrogenase complex catalyzes the overall conversion of
JL104_RS07545	COG1917	Cupin 2, conserved barrel domain protein
JL104_RS07545	COG2207	Transcriptional regulator
JL104_RS07555	COG1082	Xylose isomerase domain protein TIM barrel
JL104_RS07565	COG0673	inositol 2-dehydrogenase activity
JL104_RS07575	COG4152	abc transporter atp-binding protein
JL104_RS07595	COG0714	Associated with various cellular activities
JL104_RS07600	COG4548	von Willebrand factor, type A
JL104_RS07605	COG1114	Component of the transport system for branched-chain amino acids
JL104_RS07610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JL104_RS07615	COG3853	Toxic anion resistance protein (TelA)
JL104_RS07625	COG1254	Belongs to the acylphosphatase family
JL104_RS07635	COG1278	Cold shock
JL104_RS07650	COG1473	amidohydrolase
JL104_RS07660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JL104_RS07665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JL104_RS07670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JL104_RS07675	COG0527	aspartate kinase activity
JL104_RS07685	COG0488	(ABC) transporter
JL104_RS07690	COG2996	Protein conserved in bacteria
JL104_RS07695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JL104_RS07700	COG0573	inorganic phosphate transmembrane transporter activity
JL104_RS07705	COG0581	inorganic phosphate transmembrane transporter activity
JL104_RS07710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JL104_RS07720	COG1164	Oligoendopeptidase f
JL104_RS07750	COG0159	tryptophan synthase activity
JL104_RS07755	COG0133	tryptophan synthase activity
JL104_RS07765	COG0134	indole-3-glycerol-phosphate synthase activity
JL104_RS07770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JL104_RS07775	COG0512	Glutamine amidotransferase of anthranilate synthase
JL104_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JL104_RS07795	COG1363	Peptidase, m42
JL104_RS07805	COG0287	Prephenate dehydrogenase
JL104_RS07810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JL104_RS07815	COG1942	4-Oxalocrotonate Tautomerase
JL104_RS07830	COG1879	ABC-type sugar transport system periplasmic component
JL104_RS07835	COG1172	Belongs to the binding-protein-dependent transport system permease family
JL104_RS07840	COG1129	ABC transporter
JL104_RS07845	COG1869	D-ribose catabolic process
JL104_RS07850	COG1609	Transcriptional regulator
JL104_RS07865	COG0628	permease
JL104_RS07875	COG3711	transcriptional antiterminator
JL104_RS07880	COG1115	amino acid carrier protein
JL104_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JL104_RS07895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JL104_RS07900	COG4841	protein insertion into membrane
JL104_RS07910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JL104_RS07915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JL104_RS07920	COG1970	mechanosensitive ion channel activity
JL104_RS07925	COG0419	ATPase involved in DNA repair
JL104_RS07930	COG0420	3'-5' exonuclease activity
JL104_RS07935	COG4846	Membrane protein involved in cytochrome C biogenesis
JL104_RS08030	COG0739	heme binding
JL104_RS08120	COG3331	DNA recombination
JL104_RS08155	COG1396	sequence-specific DNA binding
JL104_RS08185	COG0756	dUTP diphosphatase activity
JL104_RS08250	COG1484	DNA-dependent DNA replication
JL104_RS08270	COG3723	Recombinational DNA repair protein, rece pathway
JL104_RS08280	COG5377	YqaJ viral recombinase family
JL104_RS08310	COG3620	sequence-specific DNA binding
JL104_RS08320	COG0582	viral genome integration into host DNA
JL104_RS08325	COG3763	UPF0154 protein
JL104_RS08345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JL104_RS08355	COG0516	GMP reductase activity
JL104_RS08360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JL104_RS08365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JL104_RS08375	COG0753	catalase activity
JL104_RS08380	COG0833	amino acid
JL104_RS08395	COG0083	homoserine kinase activity
JL104_RS08400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JL104_RS08405	COG0460	homoserine dehydrogenase
JL104_RS08410	COG0527	aspartate kinase activity
JL104_RS08450	COG0174	glutamine synthetase
JL104_RS08455	COG0789	Transcriptional regulator
JL104_RS08460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JL104_RS08465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JL104_RS08470	COG0386	Belongs to the glutathione peroxidase family
JL104_RS08475	COG1923	regulation of RNA biosynthetic process
JL104_RS08480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JL104_RS08505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JL104_RS08510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JL104_RS08515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JL104_RS08520	COG1619	proteins homologs of microcin C7 resistance protein MccF
JL104_RS08530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JL104_RS08535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JL104_RS08540	COG1472	Belongs to the glycosyl hydrolase 3 family
JL104_RS08555	COG2207	Transcriptional regulator
JL104_RS08565	COG4550	Control of competence regulator ComK, YlbF/YmcA
JL104_RS08570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JL104_RS08580	COG0492	ferredoxin-NADP+ reductase activity
JL104_RS08585	COG1959	2 iron, 2 sulfur cluster binding
JL104_RS08595	COG1013	pyruvate-flavodoxin oxidoreductase activity
JL104_RS08600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JL104_RS08600	COG0674	pyruvate-flavodoxin oxidoreductase activity
JL104_RS08605	COG1692	metallophosphoesterase
JL104_RS08615	COG1418	mRNA catabolic process
JL104_RS08620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JL104_RS08625	COG1546	Belongs to the CinA family
JL104_RS08625	COG1058	Belongs to the CinA family
JL104_RS08645	COG0300	oxidoreductase activity
JL104_RS08650	COG0612	Peptidase, M16
JL104_RS08655	COG0612	Peptidase, M16
JL104_RS08660	COG2188	Transcriptional regulator
JL104_RS08665	COG1674	ftsk spoiiie
JL104_RS08670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JL104_RS08675	COG1185	polyribonucleotide nucleotidyltransferase activity
JL104_RS08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JL104_RS08685	COG0196	riboflavin kinase activity
JL104_RS08690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JL104_RS08695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JL104_RS08710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JL104_RS08715	COG1358	cellular component organization or biogenesis
JL104_RS08720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JL104_RS08725	COG0195	Participates in both transcription termination and antitermination
JL104_RS08730	COG0779	Required for maturation of 30S ribosomal subunits
JL104_RS08735	COG2176	DNA-directed DNA polymerase activity
JL104_RS08740	COG0442	prolyl-tRNA aminoacylation
JL104_RS08750	COG4589	Belongs to the CDS family
JL104_RS08755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JL104_RS08760	COG0233	cytoplasmic translational termination
JL104_RS08765	COG0528	UMP kinase activity
JL104_RS08770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JL104_RS08775	COG0052	Belongs to the universal ribosomal protein uS2 family
JL104_RS08780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JL104_RS08785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JL104_RS08790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JL104_RS08795	COG4974	Belongs to the 'phage' integrase family
JL104_RS08800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JL104_RS08805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JL104_RS08810	COG0758	DNA mediated transformation
JL104_RS08820	COG0045	succinate-CoA ligase (ADP-forming) activity
JL104_RS08825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JL104_RS08835	COG4485	Bacterial membrane protein, YfhO
JL104_RS08845	COG0335	large ribosomal subunit rRNA binding
JL104_RS08850	COG0336	Belongs to the RNA methyltransferase TrmD family
JL104_RS08855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JL104_RS08860	COG0228	four-way junction DNA binding
JL104_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS08870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JL104_RS08875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JL104_RS08880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JL104_RS08885	COG0552	protein localization to endoplasmic reticulum
JL104_RS08890	COG1196	nuclear chromosome segregation
JL104_RS08895	COG0571	ribonuclease III activity
JL104_RS08900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JL104_RS08915	COG0416	fatty acid biosynthetic process
JL104_RS08920	COG1349	DNA-binding transcription factor activity
JL104_RS08930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JL104_RS08935	COG1760	l-serine dehydratase
JL104_RS08940	COG1760	l-serine dehydratase
JL104_RS08945	COG1461	Dihydroxyacetone kinase
JL104_RS08950	COG1302	Protein conserved in bacteria
JL104_RS08955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JL104_RS08960	COG1564	THIamine pyrophosphokinase
JL104_RS08965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JL104_RS08970	COG1162	GTPase activity
JL104_RS08980	COG0631	protein serine/threonine phosphatase activity
JL104_RS08985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JL104_RS08990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JL104_RS08990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JL104_RS08995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JL104_RS09000	COG0242	peptide deformylase activity
JL104_RS09015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JL104_RS09020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JL104_RS09025	COG1758	RNA polymerase activity
JL104_RS09030	COG0194	GDP metabolic process
JL104_RS09035	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JL104_RS09045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JL104_RS09055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JL104_RS09060	COG0284	orotidine-5'-phosphate decarboxylase activity
JL104_RS09065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JL104_RS09070	COG0505	Belongs to the CarA family
JL104_RS09080	COG0540	Belongs to the ATCase OTCase family
JL104_RS09085	COG2233	PERMEase
JL104_RS09090	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JL104_RS09095	COG0564	pseudouridine synthase activity
JL104_RS09100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JL104_RS09105	COG1388	LysM domain
JL104_RS09105	COG3942	CHAP domain
JL104_RS09115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JL104_RS09120	COG3599	regulation of cell shape
JL104_RS09125	COG2302	S4 RNA-binding domain
JL104_RS09130	COG0762	integral membrane protein
JL104_RS09135	COG1799	cell septum assembly
JL104_RS09140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JL104_RS09145	COG1496	oxidoreductase activity
JL104_RS09150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JL104_RS09155	COG0849	cell division
JL104_RS09160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JL104_RS09165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JL104_RS09170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JL104_RS09175	COG0768	penicillin binding
JL104_RS09180	COG4839	cell division protein FtsL
JL104_RS09185	COG0275	rRNA processing
JL104_RS09190	COG2001	Belongs to the MraZ family
JL104_RS09195	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JL104_RS09200	COG0454	-acetyltransferase
JL104_RS09205	COG1011	Hydrolase
JL104_RS09235	COG0584	glycerophosphoryl diester phosphodiesterase
JL104_RS09260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JL104_RS09265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JL104_RS09270	COG1053	succinate dehydrogenase
JL104_RS09275	COG2009	succinate dehydrogenase
JL104_RS09280	COG0322	excinuclease ABC activity
JL104_RS09285	COG3118	belongs to the thioredoxin family
JL104_RS09290	COG1193	negative regulation of DNA recombination
JL104_RS09295	COG1796	DNA polymerase
JL104_RS09295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JL104_RS09305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JL104_RS09310	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JL104_RS09315	COG0072	phenylalanine-tRNA ligase activity
JL104_RS09320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JL104_RS09325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JL104_RS09335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JL104_RS09345	COG1323	Belongs to the UPF0348 family
JL104_RS09350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JL104_RS09355	COG0742	ribosomal rna small subunit methyltransferase
JL104_RS09365	COG4471	UPF0298 protein
JL104_RS09375	COG3679	Belongs to the UPF0342 family
JL104_RS09395	COG0109	protoheme IX farnesyltransferase activity
JL104_RS09400	COG1612	heme a metabolic process
JL104_RS09410	COG0772	Belongs to the SEDS family
JL104_RS09415	COG4838	Belongs to the UPF0358 family
JL104_RS09420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JL104_RS09425	COG4896	Protein conserved in bacteria
JL104_RS09430	COG1217	gtp-binding protein TYPA
JL104_RS09440	COG0483	inositol monophosphate 1-phosphatase activity
JL104_RS09445	COG4493	Belongs to the UPF0637 family
JL104_RS09465	COG1177	transmembrane transport
JL104_RS09475	COG3842	ATPase activity
JL104_RS09480	COG4476	Belongs to the UPF0223 family
JL104_RS09490	COG0508	dehydrogenase complex catalyzes the overall conversion of
JL104_RS09510	COG0242	peptide deformylase activity
JL104_RS09520	COG5503	Protein of unknown function (DUF1447)
JL104_RS09525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JL104_RS09530	COG0569	domain protein
JL104_RS09535	COG1294	oxidase, subunit
JL104_RS09540	COG1271	oxidase subunit
JL104_RS09550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JL104_RS09555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JL104_RS09565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JL104_RS09585	COG4172	Belongs to the ABC transporter superfamily
JL104_RS09595	COG0151	Belongs to the GarS family
JL104_RS09600	COG0138	bifunctional purine biosynthesis protein purh
JL104_RS09610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JL104_RS09620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JL104_RS09625	COG0047	phosphoribosylformylglycinamidine synthase activity
JL104_RS09630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JL104_RS09635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JL104_RS09640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JL104_RS09645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JL104_RS09650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JL104_RS09665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JL104_RS09670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JL104_RS09675	COG1845	cytochrome c oxidase, subunit III
JL104_RS09680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JL104_RS09695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JL104_RS09700	COG1316	TRANSCRIPTIONal
JL104_RS09730	COG3594	Acyltransferase
JL104_RS09735	COG0436	Aminotransferase
JL104_RS09745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JL104_RS09755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JL104_RS09760	COG1169	isochorismate synthase
JL104_RS09765	COG1575	Belongs to the MenA family. Type 1 subfamily
JL104_RS09775	COG2314	TM2 domain
JL104_RS09785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JL104_RS09790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JL104_RS09810	COG4903	ComK protein
JL104_RS09825	COG4873	Protein conserved in bacteria
JL104_RS09835	COG0737	Belongs to the 5'-nucleotidase family
JL104_RS09840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JL104_RS09845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JL104_RS09850	COG0861	Integral membrane protein TerC family
JL104_RS09855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JL104_RS09865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JL104_RS09870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JL104_RS09875	COG2814	Major facilitator Superfamily
JL104_RS09880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JL104_RS09885	COG2382	esterase
JL104_RS09890	COG1115	amino acid carrier protein
JL104_RS09895	COG0628	permease
JL104_RS09905	COG0475	glutathione-regulated potassium exporter activity
JL104_RS09905	COG0569	domain protein
JL104_RS09910	COG2239	Acts as a magnesium transporter
JL104_RS09915	COG0564	pseudouridine synthase activity
JL104_RS09920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JL104_RS09925	COG2357	RelA SpoT domain protein
JL104_RS09935	COG4116	CYTH
JL104_RS09940	COG2346	COG2346, Truncated hemoglobins
JL104_RS09945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JL104_RS09950	COG2910	NAD(P)H-binding
JL104_RS09955	COG1164	Oligoendopeptidase f
JL104_RS09965	COG4862	establishment of competence for transformation
JL104_RS09970	COG1393	Belongs to the ArsC family
JL104_RS09975	COG0180	Tryptophanyl-tRNA synthetase
JL104_RS09980	COG4166	transmembrane transport
JL104_RS09985	COG4608	Belongs to the ABC transporter superfamily
JL104_RS09990	COG0444	Belongs to the ABC transporter superfamily
JL104_RS09995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JL104_RS10000	COG0601	transmembrane transport
JL104_RS10020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JL104_RS10030	COG0542	response to heat
JL104_RS10050	COG0561	phosphatase activity
JL104_RS10055	COG0446	pyridine nucleotide-disulphide oxidoreductase
JL104_RS10065	COG0179	Fumarylacetoacetate (FAA) hydrolase
JL104_RS10070	COG2311	Membrane
JL104_RS10075	COG1074	ATP-dependent DNA helicase activity
JL104_RS10080	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JL104_RS10095	COG0398	Pfam SNARE associated Golgi protein
JL104_RS10100	COG0166	Belongs to the GPI family
JL104_RS10105	COG0137	argininosuccinate synthase activity
JL104_RS10110	COG0165	Argininosuccinate lyase
JL104_RS10115	COG0584	glycerophosphoryl diester phosphodiesterase
JL104_RS10120	COG2832	Protein of unknown function (DUF454)
JL104_RS10140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JL104_RS10145	COG1902	pentaerythritol trinitrate reductase activity
JL104_RS10150	COG1098	S1 RNA binding domain
JL104_RS10155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JL104_RS10165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JL104_RS10165	COG2111	Na H antiporter
JL104_RS10170	COG2111	Na H antiporter
JL104_RS10175	COG1006	Multisubunit Na H antiporter MnhC subunit
JL104_RS10180	COG0651	ATP synthesis coupled electron transport
JL104_RS10185	COG1863	multisubunit Na H antiporter MnhE subunit
JL104_RS10190	COG2212	antiporter activity
JL104_RS10195	COG1320	monovalent cation:proton antiporter activity
JL104_RS10205	COG2050	protein possibly involved in aromatic compounds catabolism
JL104_RS10210	COG2056	Na+-H+ antiporter family
JL104_RS10215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JL104_RS10220	COG1252	NADH dehydrogenase
JL104_RS10225	COG0316	Belongs to the HesB IscA family
JL104_RS10230	COG4844	belongs to the
JL104_RS10235	COG1252	NADH dehydrogenase
JL104_RS10240	COG4837	Protein of unknown function (DUF1462)
JL104_RS10245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JL104_RS10250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JL104_RS10255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JL104_RS10260	COG1696	Membrane protein involved in D-alanine export
JL104_RS10265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JL104_RS10285	COG0647	UMP catabolic process
JL104_RS10290	COG2445	Protein of unknown function DUF86
JL104_RS10300	COG4470	Protein conserved in bacteria
JL104_RS10305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JL104_RS10310	COG0737	Belongs to the 5'-nucleotidase family
JL104_RS10315	COG0730	response to heat
JL104_RS10320	COG1801	Protein of unknown function DUF72
JL104_RS10325	COG2070	2-Nitropropane dioxygenase
JL104_RS10330	COG4536	flavin adenine dinucleotide binding
JL104_RS10335	COG0719	Fe-S assembly protein
JL104_RS10340	COG0822	iron-sulfur transferase activity
JL104_RS10345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JL104_RS10350	COG0719	Fe-S assembly protein
JL104_RS10355	COG0396	ATPase activity
JL104_RS10365	COG1253	flavin adenine dinucleotide binding
JL104_RS10375	COG0156	8-amino-7-oxononanoate synthase activity
JL104_RS10385	COG1464	Belongs to the NlpA lipoprotein family
JL104_RS10390	COG2011	ABC-type metal ion transport system permease component
JL104_RS10395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JL104_RS10400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JL104_RS10405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JL104_RS10410	COG0509	glycine decarboxylation via glycine cleavage system
JL104_RS10415	COG1393	Belongs to the ArsC family
JL104_RS10420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JL104_RS10430	COG0710	3-dehydroquinate dehydratase activity
JL104_RS10435	COG1764	response to oxidative stress
JL104_RS10450	COG2851	Citrate transporter
JL104_RS10465	COG2314	TM2 domain
JL104_RS10515	COG0346	lactoylglutathione lyase activity
JL104_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS10560	COG1278	Cold shock
JL104_RS10575	COG0384	phenazine biosynthesis protein PhzF
JL104_RS10650	COG0456	acetyltransferase
JL104_RS10770	COG1396	sequence-specific DNA binding
JL104_RS10785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JL104_RS10790	COG0557	exoribonuclease II activity
JL104_RS10795	COG1647	Serine aminopeptidase, S33
JL104_RS10800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JL104_RS10810	COG0148	phosphopyruvate hydratase activity
JL104_RS10815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JL104_RS10820	COG0149	triose-phosphate isomerase activity
JL104_RS10825	COG0126	phosphoglycerate kinase activity
JL104_RS10855	COG1090	epimerase
JL104_RS10860	COG0740	serine-type endopeptidase activity
JL104_RS10895	COG1316	TRANSCRIPTIONal
JL104_RS10900	COG1388	LysM domain
JL104_RS10900	COG5632	N-Acetylmuramoyl-L-alanine amidase
JL104_RS11095	COG1484	DNA-dependent DNA replication
JL104_RS11170	COG3646	Phage regulatory protein
JL104_RS11170	COG3645	SOS response
JL104_RS11215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JL104_RS11220	COG1481	regulation of sporulation
JL104_RS11225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JL104_RS11230	COG1660	Displays ATPase and GTPase activities
JL104_RS11245	COG0110	maltose O-acetyltransferase activity
JL104_RS11250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JL104_RS11255	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JL104_RS11260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JL104_RS11265	COG0556	nucleotide-excision repair
JL104_RS11280	COG1388	LysM domain
JL104_RS11280	COG3942	CHAP domain
JL104_RS11290	COG0653	protein targeting
JL104_RS11295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JL104_RS11300	COG1040	competence protein
JL104_RS11305	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JL104_RS11315	COG1739	Uncharacterized protein family UPF0029
JL104_RS11320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JL104_RS11325	COG2199	diguanylate cyclase activity
JL104_RS11340	COG2195	Cleaves the N-terminal amino acid of tripeptides
JL104_RS11345	COG1929	Belongs to the glycerate kinase type-1 family
JL104_RS11365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JL104_RS11380	COG4607	ABC-type enterochelin transport system periplasmic component
JL104_RS11385	COG4604	ABC transporter, ATP-binding protein
JL104_RS11390	COG4605	iron ion homeostasis
JL104_RS11395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JL104_RS11405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JL104_RS11410	COG1780	Probably involved in ribonucleotide reductase function
JL104_RS11420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JL104_RS11425	COG3104	oligopeptide transport
JL104_RS11430	COG3104	oligopeptide transport
JL104_RS11435	COG1597	lipid kinase activity
JL104_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JL104_RS11450	COG1174	glycine betaine transport
JL104_RS11460	COG0514	ATP-dependent DNA helicase (RecQ)
JL104_RS11465	COG0488	(ABC) transporter
JL104_RS11475	COG1368	sulfuric ester hydrolase activity
JL104_RS11485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JL104_RS11495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JL104_RS11500	COG0512	Glutamine amidotransferase of anthranilate synthase
JL104_RS11505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JL104_RS11510	COG0720	synthase
JL104_RS11515	COG0602	queuosine metabolic process
JL104_RS11530	COG0463	Glycosyl transferase, family 2
JL104_RS11535	COG0656	L-ascorbic acid biosynthetic process
JL104_RS11540	COG1253	flavin adenine dinucleotide binding
JL104_RS11545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JL104_RS11550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JL104_RS11550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JL104_RS11550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JL104_RS11555	COG1105	Belongs to the carbohydrate kinase PfkB family
JL104_RS11560	COG1349	DNA-binding transcription factor activity
JL104_RS11565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JL104_RS11570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JL104_RS11595	COG0039	L-malate dehydrogenase activity
JL104_RS11600	COG0586	Pfam SNARE associated Golgi protein
JL104_RS11610	COG4989	oxidoreductase activity
JL104_RS11615	COG0523	cobalamin synthesis protein
JL104_RS11625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JL104_RS11630	COG4988	ABC transporter
JL104_RS11635	COG1968	undecaprenyl-diphosphatase activity
JL104_RS11645	COG1671	Belongs to the UPF0178 family
JL104_RS11650	COG1611	Belongs to the LOG family
JL104_RS11655	COG1279	arginine transmembrane transporter activity
JL104_RS11660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JL104_RS11690	COG2814	Major facilitator Superfamily
JL104_RS11695	COG2839	Protein conserved in bacteria
JL104_RS11705	COG0583	DNA-binding transcription factor activity
JL104_RS11715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JL104_RS11725	COG0217	transcriptional regulatory protein
JL104_RS11740	COG3942	CHAP domain
JL104_RS11740	COG1388	LysM domain
JL104_RS11745	COG0306	phosphate transporter
JL104_RS11750	COG1392	Phosphate transport regulator
JL104_RS11755	COG2205	protein histidine kinase activity
JL104_RS11760	COG0745	RESPONSE REGULATOR receiver
JL104_RS11765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JL104_RS11780	COG3949	Membrane
JL104_RS11790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JL104_RS11795	COG1461	Dihydroxyacetone kinase
JL104_RS11800	COG2376	Dihydroxyacetone kinase
JL104_RS11805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS11810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JL104_RS11815	COG1120	ATPase activity
JL104_RS11820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JL104_RS11825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JL104_RS11830	COG1132	(ABC) transporter
JL104_RS11840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JL104_RS11850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS11855	COG1682	transport, permease protein
JL104_RS11860	COG1134	teichoic acid transport
JL104_RS11865	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JL104_RS11880	COG1121	(ABC) transporter
JL104_RS11885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JL104_RS11890	COG0803	Belongs to the bacterial solute-binding protein 9 family
JL104_RS11900	COG1320	monovalent cation:proton antiporter activity
JL104_RS11905	COG2212	antiporter activity
JL104_RS11910	COG1863	multisubunit Na H antiporter MnhE subunit
JL104_RS11915	COG0651	ATP synthesis coupled electron transport
JL104_RS11920	COG1006	Multisubunit Na H antiporter MnhC subunit
JL104_RS11925	COG2111	Na H antiporter
JL104_RS11930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JL104_RS11930	COG2111	Na H antiporter
JL104_RS11935	COG4974	Belongs to the 'phage' integrase family
JL104_RS11970	COG0596	Alpha beta hydrolase
JL104_RS11990	COG0546	phosphoglycolate phosphatase activity
JL104_RS11995	COG4139	cobalamin transport
JL104_RS12000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS12005	COG0789	Transcriptional regulator
JL104_RS12010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JL104_RS12015	COG0018	arginyl-trna synthetase
JL104_RS12030	COG1078	dGTPase activity
JL104_RS12035	COG0456	acetyltransferase
JL104_RS12040	COG0655	NAD(P)H dehydrogenase (quinone) activity
JL104_RS12045	COG0667	Aldo Keto reductase
JL104_RS12050	COG4844	belongs to the
JL104_RS12055	COG1082	Xylose isomerase domain protein TIM barrel
JL104_RS12060	COG0673	inositol 2-dehydrogenase activity
JL104_RS12070	COG0673	inositol 2-dehydrogenase activity
JL104_RS12075	COG1737	Transcriptional regulator
JL104_RS12080	COG1263	PTS System
JL104_RS12080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS12100	COG0095	Lipoate-protein ligase
JL104_RS12105	COG0280	phosphate acetyltransferase
JL104_RS12110	COG3253	May function as heme-dependent peroxidase
JL104_RS12115	COG2966	Psort location CytoplasmicMembrane, score
JL104_RS12130	COG2363	Small membrane protein
JL104_RS12140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JL104_RS12175	COG0183	Belongs to the thiolase family
JL104_RS12180	COG0318	PFAM AMP-dependent synthetase and ligase
JL104_RS12185	COG1115	amino acid carrier protein
JL104_RS12195	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JL104_RS12205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JL104_RS12210	COG1469	GTP cyclohydrolase I activity
JL104_RS12225	COG0431	NADPH-dependent FMN reductase
JL104_RS12230	COG0561	phosphatase activity
JL104_RS12240	COG1428	Deoxynucleoside kinase
JL104_RS12245	COG1428	Deoxynucleoside kinase
JL104_RS12255	COG0546	phosphoglycolate phosphatase activity
JL104_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS12335	COG0604	alcohol dehydrogenase
JL104_RS12340	COG4221	oxidoreductase activity
JL104_RS12365	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JL104_RS12370	COG1733	regulation of RNA biosynthetic process
JL104_RS12380	COG1063	alcohol dehydrogenase
JL104_RS12385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JL104_RS12390	COG0693	protein deglycase activity
JL104_RS12395	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JL104_RS12400	COG3321	synthase
JL104_RS12400	COG0604	alcohol dehydrogenase
JL104_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS12445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JL104_RS12460	COG4607	ABC-type enterochelin transport system periplasmic component
JL104_RS12475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JL104_RS12480	COG1522	sequence-specific DNA binding
JL104_RS12485	COG2814	Major facilitator Superfamily
JL104_RS12490	COG1309	transcriptional regulator
JL104_RS12495	COG3848	Pyruvate phosphate dikinase
JL104_RS12495	COG0574	Belongs to the PEP-utilizing enzyme family
JL104_RS12500	COG0574	Belongs to the PEP-utilizing enzyme family
JL104_RS12500	COG3848	Pyruvate phosphate dikinase
JL104_RS12510	COG1131	(ABC) transporter
JL104_RS12525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JL104_RS12540	COG3239	Fatty acid desaturase
JL104_RS12545	COG2040	homocysteine
JL104_RS12550	COG0833	amino acid
JL104_RS12560	COG0010	Belongs to the arginase family
JL104_RS12565	COG1914	H( )-stimulated, divalent metal cation uptake system
JL104_RS12570	COG1069	ribulokinase activity
JL104_RS12575	COG1132	(ABC) transporter
JL104_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS12585	COG1312	Catalyzes the dehydration of D-mannonate
JL104_RS12590	COG1904	glucuronate isomerase
JL104_RS12615	COG0800	Aldolase
JL104_RS12625	COG0583	DNA-binding transcription factor activity
JL104_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS12665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JL104_RS12670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JL104_RS12685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JL104_RS12685	COG1215	transferase activity, transferring glycosyl groups
JL104_RS12700	COG1473	amidohydrolase
JL104_RS12705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JL104_RS12710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JL104_RS12715	COG0049	tRNA binding
JL104_RS12720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JL104_RS12730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JL104_RS12735	COG0085	RNA polymerase activity
JL104_RS12740	COG2813	Specifically methylates the guanine in position
JL104_RS12750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JL104_RS12755	COG0081	regulation of translation
JL104_RS12760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JL104_RS12765	COG0250	Participates in transcription elongation, termination and antitermination
JL104_RS12775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JL104_RS12785	COG3688	RNA-binding protein containing a PIN domain
JL104_RS12790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JL104_RS12795	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JL104_RS12800	COG0215	cysteine-tRNA ligase activity
JL104_RS12805	COG1045	serine acetyltransferase
JL104_RS12810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JL104_RS12815	COG4956	integral membrane protein (PIN domain superfamily)
JL104_RS12820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JL104_RS12825	COG0542	response to heat
JL104_RS12830	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JL104_RS12835	COG3880	PFAM UvrB UvrC protein
JL104_RS12840	COG4463	regulation of RNA biosynthetic process
JL104_RS12845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JL104_RS12850	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JL104_RS12855	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JL104_RS12860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JL104_RS12945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JL104_RS12950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JL104_RS12970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JL104_RS12975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JL104_RS12990	COG1098	S1 RNA binding domain
JL104_RS13000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JL104_RS13005	COG3956	TIGRFAM MazG family protein
JL104_RS13010	COG2244	polysaccharide biosynthetic process
JL104_RS13015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JL104_RS13020	COG0193	aminoacyl-tRNA hydrolase activity
JL104_RS13025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JL104_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JL104_RS13035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JL104_RS13040	COG2088	sporulation resulting in formation of a cellular spore
JL104_RS13045	COG0251	oxidation-reduction process
JL104_RS13050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JL104_RS13055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JL104_RS13060	COG4466	Protein conserved in bacteria
JL104_RS13065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JL104_RS13070	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JL104_RS13075	COG0084	hydrolase, TatD family'
JL104_RS13080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JL104_RS13080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JL104_RS13085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JL104_RS13090	COG2827	Endonuclease containing a URI domain
JL104_RS13095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JL104_RS13100	COG4467	Involved in initiation control of chromosome replication
JL104_RS13105	COG1774	PSP1 C-terminal conserved region
JL104_RS13110	COG0470	DNA polymerase III
JL104_RS13115	COG3870	Protein conserved in bacteria
JL104_RS13120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JL104_RS13125	COG1982	Orn Lys Arg decarboxylase major
JL104_RS13160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JL104_RS13165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JL104_RS13170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JL104_RS13175	COG3153	acetyltransferase
JL104_RS13185	COG2188	Transcriptional regulator
JL104_RS13190	COG0366	Alpha amylase catalytic
JL104_RS13195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JL104_RS13195	COG1263	PTS System
JL104_RS13205	COG0493	'glutamate synthase
JL104_RS13210	COG0067	glutamate synthase
JL104_RS13210	COG0070	glutamate synthase
JL104_RS13210	COG0069	glutamate synthase activity
JL104_RS13215	COG0583	DNA-binding transcription factor activity
JL104_RS13230	COG0004	ammonium transporteR
JL104_RS13245	COG3942	CHAP domain
JL104_RS13245	COG1388	LysM domain
JL104_RS13255	COG0129	dihydroxy-acid dehydratase activity
JL104_RS13260	COG0733	neurotransmitter:sodium symporter activity
JL104_RS13265	COG1114	Component of the transport system for branched-chain amino acids
JL104_RS13270	COG5646	InterPro IPR014922
JL104_RS13285	COG4195	phage-related replication protein
JL104_RS13290	COG2807	transmembrane transport
JL104_RS13295	COG0406	alpha-ribazole phosphatase activity
JL104_RS13305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JL104_RS13315	COG1595	DNA-templated transcription, initiation
JL104_RS13325	COG0583	DNA-binding transcription factor activity
JL104_RS13330	COG2814	Major facilitator Superfamily
JL104_RS13390	COG0519	Catalyzes the synthesis of GMP from XMP
JL104_RS13390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JL104_RS13395	COG0516	GMP reductase activity
JL104_RS13395	COG0517	IMP dehydrogenase activity
JL104_RS13400	COG2233	PERMEase
JL104_RS13405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JL104_RS13420	COG5183	chlorophyll binding
JL104_RS13425	COG1823	symporter activity
JL104_RS13435	COG0778	Nitroreductase
JL104_RS13445	COG0753	catalase activity
JL104_RS13450	COG3620	sequence-specific DNA binding
JL104_RS13455	COG3279	Response regulator of the LytR AlgR family
JL104_RS13470	COG0450	alkyl hydroperoxide reductase
JL104_RS13475	COG3634	alkyl hydroperoxide reductase activity
JL104_RS13490	COG0588	phosphoglycerate mutase activity
JL104_RS13500	COG1280	lysine exporter protein (LysE YggA)
JL104_RS13505	COG2076	Multidrug Resistance protein
JL104_RS13510	COG2076	Multidrug Resistance protein
JL104_RS13525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JL104_RS13540	COG4195	phage-related replication protein
JL104_RS13555	COG2723	6-phospho-beta-galactosidase activity
JL104_RS13565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JL104_RS13590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JL104_RS13600	COG0360	Binds together with S18 to 16S ribosomal RNA
JL104_RS13610	COG0012	GTP binding
JL104_RS13615	COG4481	Protein conserved in bacteria
JL104_RS13620	COG0668	transmembrane transport
JL104_RS13625	COG5609	conserved protein (DUF2294)
JL104_RS13630	COG3002	Belongs to the UPF0753 family
JL104_RS13635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JL104_RS13640	COG2169	Transcriptional regulator
JL104_RS13645	COG1486	melibiose metabolic process
JL104_RS13650	COG2211	Major facilitator Superfamily
JL104_RS13660	COG0300	oxidoreductase activity
JL104_RS13685	COG2314	TM2 domain
JL104_RS13700	COG1388	LysM domain
JL104_RS13705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JL104_RS13710	COG2814	Major facilitator Superfamily
JL104_RS13715	COG1473	amidohydrolase
JL104_RS13720	COG2814	Major facilitator Superfamily
JL104_RS13725	COG1733	regulation of RNA biosynthetic process
JL104_RS13730	COG1120	ATPase activity
JL104_RS13765	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS13770	COG2030	dehydratase
JL104_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS13780	COG1846	Transcriptional regulator
JL104_RS13795	COG0753	catalase activity
JL104_RS13810	COG1131	(ABC) transporter
JL104_RS13835	COG0772	Belongs to the SEDS family
JL104_RS13845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JL104_RS13850	COG0529	Catalyzes the synthesis of activated sulfate
JL104_RS13855	COG2046	Belongs to the sulfate adenylyltransferase family
JL104_RS13860	COG0730	response to heat
JL104_RS13880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JL104_RS13885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JL104_RS13890	COG0175	sulfate reduction
JL104_RS13895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JL104_RS13895	COG1017	nitric oxide dioxygenase activity
JL104_RS13900	COG1228	amidohydrolase
JL104_RS13905	COG1475	DNA binding
JL104_RS13910	COG0626	cystathionine gamma-synthase activity
JL104_RS13915	COG0626	cystathionine gamma-synthase activity
JL104_RS13920	COG0646	methionine synthase
JL104_RS13920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JL104_RS13925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JL104_RS13945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JL104_RS13955	COG0183	Belongs to the thiolase family
JL104_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
JL104_RS13985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JL104_RS14025	COG0667	Aldo Keto reductase
JL104_RS14035	COG1063	alcohol dehydrogenase
JL104_RS14045	COG0450	alkyl hydroperoxide reductase
JL104_RS14060	COG0561	phosphatase activity
JL104_RS14070	COG3732	PTS system glucitol sorbitol-specific
JL104_RS14085	COG3711	transcriptional antiterminator
JL104_RS14085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JL104_RS14125	COG0640	Transcriptional regulator
JL104_RS14130	COG3386	PFAM SMP-30 Gluconolaconase
JL104_RS14135	COG0531	amino acid
JL104_RS14145	COG0656	L-ascorbic acid biosynthetic process
JL104_RS14180	COG2211	Major facilitator Superfamily
JL104_RS14190	COG1966	Carbon starvation protein
JL104_RS14195	COG1475	DNA binding
JL104_RS14200	COG0357	Ribosomal RNA small subunit methyltransferase G
JL104_RS14205	COG0445	tRNA wobble uridine modification
JL104_RS14210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JL104_RS14215	COG0594	ribonuclease P activity
JL104_RS14250	COG0783	Belongs to the Dps family
JL104_RS14295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JL104_RS14300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JL104_RS14310	COG0446	pyridine nucleotide-disulphide oxidoreductase
JL104_RS14330	COG0640	Transcriptional regulator
JL104_RS14365	COG0456	acetyltransferase
JL104_RS14385	COG1063	alcohol dehydrogenase
JL104_RS14395	COG1607	acyl-coa hydrolase
JL104_RS14400	COG0583	DNA-binding transcription factor activity
JL104_RS14420	COG0783	Belongs to the Dps family
JL104_RS14425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JL104_RS14445	COG0730	response to heat
JL104_RS14450	COG1937	Protein conserved in bacteria
JL104_RS14455	COG2210	Belongs to the sulfur carrier protein TusA family
JL104_RS14460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JL104_RS14470	COG3321	synthase
JL104_RS14470	COG0604	alcohol dehydrogenase
JL104_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
JL104_RS14485	COG3118	belongs to the thioredoxin family
JL104_RS14505	COG0492	ferredoxin-NADP+ reductase activity
JL104_RS14515	COG1064	alcohol dehydrogenase
JL104_RS14520	COG1846	Transcriptional regulator
JL104_RS14525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JL104_RS14540	COG0583	DNA-binding transcription factor activity
JL104_RS14600	COG1388	LysM domain
JL104_RS14610	COG2132	Multicopper oxidase
JL104_RS14630	COG2348	transferase activity, transferring amino-acyl groups