locus-tag	class	description
I6H71_RS00020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H71_RS00025	COG0542	response to heat
I6H71_RS00030	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H71_RS00035	COG0561	phosphatase activity
I6H71_RS00040	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H71_RS00050	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H71_RS00060	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H71_RS00075	COG0166	Belongs to the GPI family
I6H71_RS00080	COG0137	argininosuccinate synthase activity
I6H71_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS00105	COG1098	S1 RNA binding domain
I6H71_RS00125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H71_RS00135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H71_RS00135	COG2111	Na H antiporter
I6H71_RS00140	COG2111	Na H antiporter
I6H71_RS00145	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H71_RS00150	COG0651	ATP synthesis coupled electron transport
I6H71_RS00155	COG1863	multisubunit Na H antiporter MnhE subunit
I6H71_RS00160	COG2212	antiporter activity
I6H71_RS00165	COG1320	monovalent cation:proton antiporter activity
I6H71_RS00170	COG2050	protein possibly involved in aromatic compounds catabolism
I6H71_RS00175	COG2056	Na+-H+ antiporter family
I6H71_RS00180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H71_RS00185	COG1252	NADH dehydrogenase
I6H71_RS00190	COG3344	reverse transcriptase
I6H71_RS00195	COG0316	Belongs to the HesB IscA family
I6H71_RS00200	COG4844	belongs to the
I6H71_RS00205	COG1252	NADH dehydrogenase
I6H71_RS00210	COG4837	Protein of unknown function (DUF1462)
I6H71_RS00215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6H71_RS00225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H71_RS00230	COG0647	UMP catabolic process
I6H71_RS00235	COG2445	Protein of unknown function DUF86
I6H71_RS00245	COG0706	membrane insertase activity
I6H71_RS00250	COG0529	Catalyzes the synthesis of activated sulfate
I6H71_RS00255	COG2046	Belongs to the sulfate adenylyltransferase family
I6H71_RS00260	COG0730	response to heat
I6H71_RS00275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H71_RS00280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H71_RS00285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6H71_RS00290	COG0175	sulfate reduction
I6H71_RS00295	COG4470	Protein conserved in bacteria
I6H71_RS00300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H71_RS00305	COG0737	Belongs to the 5'-nucleotidase family
I6H71_RS00310	COG0730	response to heat
I6H71_RS00315	COG1801	Protein of unknown function DUF72
I6H71_RS00325	COG2070	2-Nitropropane dioxygenase
I6H71_RS00330	COG4536	flavin adenine dinucleotide binding
I6H71_RS00335	COG0719	Fe-S assembly protein
I6H71_RS00340	COG0822	iron-sulfur transferase activity
I6H71_RS00350	COG0719	Fe-S assembly protein
I6H71_RS00355	COG0396	ATPase activity
I6H71_RS00365	COG1464	Belongs to the NlpA lipoprotein family
I6H71_RS00370	COG1464	Belongs to the NlpA lipoprotein family
I6H71_RS00375	COG2011	ABC-type metal ion transport system permease component
I6H71_RS00380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H71_RS00390	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H71_RS00400	COG1393	Belongs to the ArsC family
I6H71_RS00405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H71_RS00415	COG0710	3-dehydroquinate dehydratase activity
I6H71_RS00425	COG1764	response to oxidative stress
I6H71_RS00465	COG5002	protein histidine kinase activity
I6H71_RS00515	COG1349	DNA-binding transcription factor activity
I6H71_RS00525	COG0745	RESPONSE REGULATOR receiver
I6H71_RS00535	COG1131	(ABC) transporter
I6H71_RS00540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H71_RS00570	COG0789	Transcriptional regulator
I6H71_RS00630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H71_RS00635	COG0101	tRNA pseudouridine synthase activity
I6H71_RS00645	COG1122	ATPase activity
I6H71_RS00655	COG0203	ribosomal protein L17
I6H71_RS00660	COG0202	RNA polymerase activity
I6H71_RS00675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H71_RS00690	COG0201	protein transport
I6H71_RS00695	COG0200	Binds to the 23S rRNA
I6H71_RS00700	COG1841	ribosomal large subunit assembly
I6H71_RS00720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H71_RS00725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H71_RS00735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H71_RS00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H71_RS00750	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H71_RS00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H71_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H71_RS00770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H71_RS00775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H71_RS00780	COG0089	rRNA binding
I6H71_RS00785	COG0088	Forms part of the polypeptide exit tunnel
I6H71_RS00790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H71_RS00805	COG2252	PERMEase
I6H71_RS00830	COG0436	Aminotransferase
I6H71_RS00835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H71_RS00840	COG2348	transferase activity, transferring amino-acyl groups
I6H71_RS00865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H71_RS00870	COG0746	molybdenum cofactor guanylyltransferase activity
I6H71_RS00885	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6H71_RS00900	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H71_RS00905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H71_RS00910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6H71_RS00915	COG4149	molybdate abc transporter
I6H71_RS00920	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H71_RS00925	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H71_RS00930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H71_RS00935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H71_RS00940	COG1609	Transcriptional regulator
I6H71_RS00955	COG1268	BioY protein
I6H71_RS00960	COG1940	carbohydrate kinase activity
I6H71_RS00965	COG2186	Transcriptional regulator
I6H71_RS00975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H71_RS00980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H71_RS00985	COG2832	Protein of unknown function (DUF454)
I6H71_RS00990	COG1960	acyl-CoA dehydrogenase activity
I6H71_RS01015	COG3942	CHAP domain
I6H71_RS01020	COG1757	Na H antiporter
I6H71_RS01040	COG2076	Multidrug Resistance protein
I6H71_RS01045	COG2076	Multidrug Resistance protein
I6H71_RS01050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H71_RS01075	COG3383	formate dehydrogenase (NAD+) activity
I6H71_RS01080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H71_RS01120	COG1113	amino acid transport
I6H71_RS01145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H71_RS01150	COG0346	lactoylglutathione lyase activity
I6H71_RS01160	COG0385	Bile acid
I6H71_RS01180	COG1473	amidohydrolase
I6H71_RS01185	COG1228	amidohydrolase
I6H71_RS01190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H71_RS01195	COG3314	Sporulation integral membrane protein YlbJ
I6H71_RS01200	COG0583	DNA-binding transcription factor activity
I6H71_RS01210	COG1266	CAAX protease self-immunity
I6H71_RS01215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H71_RS01220	COG2017	converts alpha-aldose to the beta-anomer
I6H71_RS01225	COG1742	UPF0060 membrane protein
I6H71_RS01230	COG1668	transmembrane transport
I6H71_RS01235	COG4152	abc transporter atp-binding protein
I6H71_RS01240	COG1288	antiporter activity
I6H71_RS01245	COG3344	reverse transcriptase
I6H71_RS01260	COG3152	Membrane
I6H71_RS01265	COG2094	Belongs to the DNA glycosylase MPG family
I6H71_RS01270	COG1757	Na H antiporter
I6H71_RS01320	COG2207	Transcriptional regulator
I6H71_RS01325	COG0786	glutamate:sodium symporter activity
I6H71_RS01330	COG0523	cobalamin synthesis protein
I6H71_RS01350	COG0657	acetylesterase activity
I6H71_RS01355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H71_RS01365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H71_RS01375	COG4640	response to antibiotic
I6H71_RS01395	COG0577	efflux transmembrane transporter activity
I6H71_RS01400	COG0745	RESPONSE REGULATOR receiver
I6H71_RS01410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H71_RS01415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H71_RS01445	COG1234	tRNA 3'-trailer cleavage
I6H71_RS01450	COG2814	Major facilitator Superfamily
I6H71_RS01455	COG0579	oxidoreductase
I6H71_RS01460	COG0438	transferase activity, transferring glycosyl groups
I6H71_RS01465	COG1620	l-lactate permease
I6H71_RS01475	COG0604	alcohol dehydrogenase
I6H71_RS01480	COG2814	Major facilitator Superfamily
I6H71_RS01485	COG0456	acetyltransferase
I6H71_RS01510	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H71_RS01530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H71_RS01535	COG2807	transmembrane transport
I6H71_RS01545	COG0697	spore germination
I6H71_RS01550	COG1363	Peptidase, m42
I6H71_RS01560	COG4187	Peptidase family M20/M25/M40
I6H71_RS01565	COG2223	nitrite transmembrane transporter activity
I6H71_RS01570	COG2197	response regulator
I6H71_RS01575	COG4585	Histidine kinase
I6H71_RS01585	COG2181	nitrate reductase activity
I6H71_RS01590	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6H71_RS01595	COG1140	nitrate reductase beta subunit
I6H71_RS01600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6H71_RS01605	COG0737	Belongs to the 5'-nucleotidase family
I6H71_RS01615	COG2146	nitrite reductase [NAD(P)H] activity
I6H71_RS01620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H71_RS01625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H71_RS01625	COG1648	precorrin-2 dehydrogenase activity
I6H71_RS01630	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I6H71_RS01635	COG0454	-acetyltransferase
I6H71_RS01650	COG0471	metal ion transport
I6H71_RS01675	COG1760	l-serine dehydratase
I6H71_RS01680	COG1760	l-serine dehydratase
I6H71_RS01685	COG0018	arginyl-trna synthetase
I6H71_RS01700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H71_RS01705	COG0601	transmembrane transport
I6H71_RS01710	COG4608	Belongs to the ABC transporter superfamily
I6H71_RS01715	COG0444	Belongs to the ABC transporter superfamily
I6H71_RS01720	COG4166	transmembrane transport
I6H71_RS01725	COG0702	epimerase
I6H71_RS01735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H71_RS01760	COG1929	Belongs to the glycerate kinase type-1 family
I6H71_RS01765	COG3764	Sortase (surface protein transpeptidase)
I6H71_RS01770	COG2271	Major facilitator Superfamily
I6H71_RS01785	COG1115	amino acid carrier protein
I6H71_RS01800	COG1132	(ABC) transporter
I6H71_RS01805	COG1132	(ABC) transporter
I6H71_RS01805	COG2375	cellular response to nickel ion
I6H71_RS01810	COG1129	ABC transporter
I6H71_RS01845	COG1132	(ABC) transporter
I6H71_RS01850	COG1132	(ABC) transporter
I6H71_RS01860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H71_RS01865	COG0159	tryptophan synthase activity
I6H71_RS01870	COG0133	tryptophan synthase activity
I6H71_RS01875	COG0134	indole-3-glycerol-phosphate synthase activity
I6H71_RS01880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H71_RS01885	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H71_RS01890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H71_RS01895	COG3961	Belongs to the TPP enzyme family
I6H71_RS01900	COG4336	lyase activity
I6H71_RS01910	COG3344	reverse transcriptase
I6H71_RS01920	COG3835	regulator
I6H71_RS01930	COG2816	NAD+ diphosphatase activity
I6H71_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
I6H71_RS01960	COG0753	catalase activity
I6H71_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
I6H71_RS01970	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H71_RS01970	COG3583	domain protein
I6H71_RS01970	COG4932	domain protein
I6H71_RS02010	COG1136	(ABC) transporter
I6H71_RS02020	COG2357	RelA SpoT domain protein
I6H71_RS02025	COG0778	Nitroreductase
I6H71_RS02030	COG1846	Transcriptional regulator
I6H71_RS02035	COG4607	ABC-type enterochelin transport system periplasmic component
I6H71_RS02040	COG4604	ABC transporter, ATP-binding protein
I6H71_RS02045	COG4605	iron ion homeostasis
I6H71_RS02050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS02070	COG0583	DNA-binding transcription factor activity
I6H71_RS02080	COG2348	transferase activity, transferring amino-acyl groups
I6H71_RS02090	COG0717	Belongs to the dCTP deaminase family
I6H71_RS02095	COG0804	urea catabolic process
I6H71_RS02100	COG0832	Belongs to the urease beta subunit family
I6H71_RS02110	COG4413	Urea transporter
I6H71_RS02125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6H71_RS02130	COG0577	efflux transmembrane transporter activity
I6H71_RS02135	COG1136	(ABC) transporter
I6H71_RS02155	COG3001	Fructosamine kinase
I6H71_RS02160	COG0778	Nitroreductase
I6H71_RS02165	COG3181	Tripartite tricarboxylate transporter family receptor
I6H71_RS02180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H71_RS02185	COG0438	transferase activity, transferring glycosyl groups
I6H71_RS02190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H71_RS02190	COG0463	Glycosyl transferase, family 2
I6H71_RS02195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H71_RS02195	COG0463	Glycosyl transferase, family 2
I6H71_RS02220	COG0747	negative chemotaxis
I6H71_RS02225	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H71_RS02245	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H71_RS02245	COG3942	CHAP domain
I6H71_RS02260	COG2832	Protein of unknown function (DUF454)
I6H71_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS02270	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H71_RS02280	COG1461	Dihydroxyacetone kinase
I6H71_RS02285	COG2376	Dihydroxyacetone kinase
I6H71_RS02315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H71_RS02325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H71_RS02330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H71_RS02350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6H71_RS02355	COG0107	imidazoleglycerol-phosphate synthase activity
I6H71_RS02365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H71_RS02400	COG1131	(ABC) transporter
I6H71_RS02405	COG0535	radical SAM domain protein
I6H71_RS02420	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6H71_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS02430	COG1510	regulation of RNA biosynthetic process
I6H71_RS02435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H71_RS02440	COG2258	MOSC domain
I6H71_RS02450	COG3527	Alpha-acetolactate decarboxylase
I6H71_RS02460	COG1785	Belongs to the alkaline phosphatase family
I6H71_RS02485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H71_RS02490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H71_RS02505	COG1957	nucleoside hydrolase
I6H71_RS02525	COG0588	phosphoglycerate mutase activity
I6H71_RS02535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H71_RS02540	COG1115	amino acid carrier protein
I6H71_RS02575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H71_RS02595	COG3588	fructose-bisphosphate aldolase
I6H71_RS02605	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H71_RS02635	COG0602	queuosine metabolic process
I6H71_RS02640	COG1328	CTP reductase activity
I6H71_RS02670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H71_RS02670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H71_RS02675	COG1937	Protein conserved in bacteria
I6H71_RS02680	COG0730	response to heat
I6H71_RS02700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H71_RS02710	COG0579	oxidoreductase
I6H71_RS02740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H71_RS02750	COG1136	(ABC) transporter
I6H71_RS02770	COG0783	Belongs to the Dps family
I6H71_RS02775	COG2353	YceI-like domain
I6H71_RS02785	COG2388	GCN5-related N-acetyl-transferase
I6H71_RS02790	COG1846	Transcriptional regulator
I6H71_RS02795	COG0346	lactoylglutathione lyase activity
I6H71_RS02800	COG0400	carboxylic ester hydrolase activity
I6H71_RS02810	COG2801	Transposase and inactivated derivatives
I6H71_RS02835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H71_RS02855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H71_RS02860	COG2814	Major facilitator Superfamily
I6H71_RS02865	COG2318	DinB family
I6H71_RS02870	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6H71_RS02880	COG1124	(ABC) transporter
I6H71_RS02885	COG0444	Belongs to the ABC transporter superfamily
I6H71_RS02895	COG0601	transmembrane transport
I6H71_RS02900	COG0747	negative chemotaxis
I6H71_RS02920	COG1438	arginine binding
I6H71_RS02925	COG2235	arginine
I6H71_RS02955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6H71_RS02960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6H71_RS02970	COG2205	protein histidine kinase activity
I6H71_RS02975	COG0745	RESPONSE REGULATOR receiver
I6H71_RS02980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H71_RS03010	COG1335	isochorismatase
I6H71_RS03020	COG2210	Belongs to the sulfur carrier protein TusA family
I6H71_RS03025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H71_RS03030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H71_RS03045	COG0490	domain, Protein
I6H71_RS03050	COG0475	glutathione-regulated potassium exporter activity
I6H71_RS03075	COG3314	Sporulation integral membrane protein YlbJ
I6H71_RS03085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H71_RS03090	COG1278	Cold shock
I6H71_RS03095	COG1279	arginine transmembrane transporter activity
I6H71_RS03130	COG0737	Belongs to the 5'-nucleotidase family
I6H71_RS03135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6H71_RS03140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H71_RS03145	COG0156	8-amino-7-oxononanoate synthase activity
I6H71_RS03165	COG1876	peptidase activity
I6H71_RS03185	COG1482	cell wall glycoprotein biosynthetic process
I6H71_RS03190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H71_RS03190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H71_RS03190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H71_RS03195	COG3711	transcriptional antiterminator
I6H71_RS03195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H71_RS03205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6H71_RS03210	COG2814	Major facilitator Superfamily
I6H71_RS03215	COG0813	purine-nucleoside phosphorylase activity
I6H71_RS03220	COG2188	Transcriptional regulator
I6H71_RS03225	COG1454	alcohol dehydrogenase
I6H71_RS03225	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
I6H71_RS03260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6H71_RS03270	COG1869	D-ribose catabolic process
I6H71_RS03280	COG1609	Transcriptional regulator
I6H71_RS03285	COG0586	Pfam SNARE associated Golgi protein
I6H71_RS03300	COG0702	epimerase
I6H71_RS03305	COG1349	DNA-binding transcription factor activity
I6H71_RS03310	COG0534	Mate efflux family protein
I6H71_RS03320	COG0395	ABC-type sugar transport system, permease component
I6H71_RS03330	COG4209	transmembrane transport
I6H71_RS03335	COG3842	ATPase activity
I6H71_RS03340	COG0642	Histidine kinase
I6H71_RS03345	COG0745	RESPONSE REGULATOR receiver
I6H71_RS03355	COG0492	ferredoxin-NADP+ reductase activity
I6H71_RS03360	COG0415	Belongs to the DNA photolyase family
I6H71_RS03370	COG3477	response to acidic pH
I6H71_RS03395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H71_RS03405	COG1131	(ABC) transporter
I6H71_RS03410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H71_RS03415	COG0745	RESPONSE REGULATOR receiver
I6H71_RS03420	COG2205	protein histidine kinase activity
I6H71_RS03425	COG1136	(ABC) transporter
I6H71_RS03430	COG0577	efflux transmembrane transporter activity
I6H71_RS03475	COG0492	ferredoxin-NADP+ reductase activity
I6H71_RS03480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H71_RS03485	COG2207	Transcriptional regulator
I6H71_RS03530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H71_RS03540	COG4863	YycH protein
I6H71_RS03545	COG5002	protein histidine kinase activity
I6H71_RS03550	COG0745	RESPONSE REGULATOR receiver
I6H71_RS03565	COG1104	cysteine desulfurase activity
I6H71_RS03570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6H71_RS03575	COG0157	Belongs to the NadC ModD family
I6H71_RS03580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H71_RS03595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H71_RS03605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H71_RS03610	COG0305	Participates in initiation and elongation during chromosome replication
I6H71_RS03615	COG0359	binds to the 23S rRNA
I6H71_RS03620	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6H71_RS03630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H71_RS03640	COG2986	histidine ammonia-lyase
I6H71_RS03645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H71_RS03655	COG0187	DNA topoisomerase II activity
I6H71_RS03660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H71_RS03670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H71_RS03675	COG0592	DNA-directed DNA polymerase activity
I6H71_RS03680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H71_RS03690	COG0594	ribonuclease P activity
I6H71_RS03695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H71_RS03700	COG0445	tRNA wobble uridine modification
I6H71_RS03705	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H71_RS03715	COG0366	Alpha amylase catalytic
I6H71_RS03725	COG2222	sugar isomerase
I6H71_RS03730	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H71_RS03745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H71_RS03750	COG3715	PTS system
I6H71_RS03755	COG3716	PTS system mannose fructose sorbose family IID component
I6H71_RS03765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6H71_RS03780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H71_RS03805	COG1966	Carbon starvation protein
I6H71_RS03815	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6H71_RS03820	COG0830	nickel cation binding
I6H71_RS03825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6H71_RS03830	COG0829	nickel cation binding
I6H71_RS03850	COG0646	methionine synthase
I6H71_RS03850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H71_RS03855	COG0626	cystathionine gamma-synthase activity
I6H71_RS03860	COG0626	cystathionine gamma-synthase activity
I6H71_RS03865	COG1475	DNA binding
I6H71_RS03870	COG0668	transmembrane transport
I6H71_RS03875	COG4481	Protein conserved in bacteria
I6H71_RS03880	COG0012	GTP binding
I6H71_RS03890	COG2814	Major facilitator Superfamily
I6H71_RS03895	COG0494	nUDIX hydrolase
I6H71_RS03930	COG3344	reverse transcriptase
I6H71_RS03935	COG2910	NAD(P)H-binding
I6H71_RS03945	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H71_RS03955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H71_RS03960	COG1464	Belongs to the NlpA lipoprotein family
I6H71_RS03965	COG2011	ABC-type metal ion transport system permease component
I6H71_RS03970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H71_RS03990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H71_RS04000	COG3634	alkyl hydroperoxide reductase activity
I6H71_RS04005	COG0450	alkyl hydroperoxide reductase
I6H71_RS04025	COG0778	Nitroreductase
I6H71_RS04030	COG1823	symporter activity
I6H71_RS04035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H71_RS04040	COG5183	chlorophyll binding
I6H71_RS04055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H71_RS04060	COG2233	PERMEase
I6H71_RS04065	COG0516	GMP reductase activity
I6H71_RS04065	COG0517	IMP dehydrogenase activity
I6H71_RS04070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H71_RS04070	COG0519	Catalyzes the synthesis of GMP from XMP
I6H71_RS04095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6H71_RS04105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6H71_RS04105	COG0456	acetyltransferase
I6H71_RS04120	COG0531	amino acid
I6H71_RS04145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H71_RS04155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H71_RS04155	COG0574	Belongs to the PEP-utilizing enzyme family
I6H71_RS04160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H71_RS04180	COG0733	neurotransmitter:sodium symporter activity
I6H71_RS04185	COG2272	Belongs to the type-B carboxylesterase lipase family
I6H71_RS04190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H71_RS04195	COG0626	cystathionine gamma-synthase activity
I6H71_RS04215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H71_RS04230	COG0583	DNA-binding transcription factor activity
I6H71_RS04235	COG0069	glutamate synthase activity
I6H71_RS04235	COG0067	glutamate synthase
I6H71_RS04235	COG0070	glutamate synthase
I6H71_RS04240	COG0493	'glutamate synthase
I6H71_RS04250	COG2814	Major facilitator Superfamily
I6H71_RS04255	COG1263	PTS System
I6H71_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H71_RS04260	COG0366	Alpha amylase catalytic
I6H71_RS04265	COG2188	Transcriptional regulator
I6H71_RS04280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H71_RS04285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H71_RS04290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H71_RS04315	COG1982	Orn Lys Arg decarboxylase major
I6H71_RS04320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H71_RS04325	COG3870	Protein conserved in bacteria
I6H71_RS04330	COG0470	DNA polymerase III
I6H71_RS04335	COG1774	PSP1 C-terminal conserved region
I6H71_RS04340	COG4467	Involved in initiation control of chromosome replication
I6H71_RS04345	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H71_RS04350	COG2827	Endonuclease containing a URI domain
I6H71_RS04355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H71_RS04360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H71_RS04360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H71_RS04365	COG0084	hydrolase, TatD family'
I6H71_RS04370	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H71_RS04375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H71_RS04380	COG4466	Protein conserved in bacteria
I6H71_RS04385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H71_RS04390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H71_RS04395	COG0251	oxidation-reduction process
I6H71_RS04400	COG2088	sporulation resulting in formation of a cellular spore
I6H71_RS04405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H71_RS04410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H71_RS04415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H71_RS04425	COG0193	aminoacyl-tRNA hydrolase activity
I6H71_RS04430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H71_RS04435	COG2244	polysaccharide biosynthetic process
I6H71_RS04440	COG3956	TIGRFAM MazG family protein
I6H71_RS04445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H71_RS04455	COG1098	S1 RNA binding domain
I6H71_RS04470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H71_RS04475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H71_RS04485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H71_RS04495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H71_RS04500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H71_RS04505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H71_RS04595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H71_RS04600	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6H71_RS04605	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6H71_RS04610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H71_RS04620	COG3880	PFAM UvrB UvrC protein
I6H71_RS04625	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6H71_RS04635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H71_RS04640	COG4956	integral membrane protein (PIN domain superfamily)
I6H71_RS04650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H71_RS04660	COG1045	serine acetyltransferase
I6H71_RS04665	COG0215	cysteine-tRNA ligase activity
I6H71_RS04670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H71_RS04680	COG3688	RNA-binding protein containing a PIN domain
I6H71_RS04690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H71_RS04695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H71_RS04700	COG0250	Participates in transcription elongation, termination and antitermination
I6H71_RS04705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H71_RS04710	COG0081	regulation of translation
I6H71_RS04715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H71_RS04725	COG2813	Specifically methylates the guanine in position
I6H71_RS04735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H71_RS04745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H71_RS04750	COG0049	tRNA binding
I6H71_RS04755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H71_RS04760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H71_RS04765	COG1473	amidohydrolase
I6H71_RS04775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H71_RS04790	COG0546	phosphoglycolate phosphatase activity
I6H71_RS04795	COG1428	Deoxynucleoside kinase
I6H71_RS04800	COG1428	Deoxynucleoside kinase
I6H71_RS04810	COG0561	phosphatase activity
I6H71_RS04815	COG0431	NADPH-dependent FMN reductase
I6H71_RS04825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6H71_RS04835	COG0517	IMP dehydrogenase activity
I6H71_RS04835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H71_RS04840	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H71_RS04845	COG0363	glucosamine-6-phosphate deaminase activity
I6H71_RS04850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6H71_RS04865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H71_RS04875	COG2363	Small membrane protein
I6H71_RS04880	COG0531	amino acid
I6H71_RS04885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H71_RS04905	COG1566	PFAM secretion protein HlyD family protein
I6H71_RS04910	COG2814	Major facilitator Superfamily
I6H71_RS04920	COG0095	Lipoate-protein ligase
I6H71_RS04925	COG0280	phosphate acetyltransferase
I6H71_RS04935	COG0531	amino acid
I6H71_RS04950	COG0471	metal ion transport
I6H71_RS04955	COG4844	belongs to the
I6H71_RS04965	COG1078	dGTPase activity
I6H71_RS04985	COG0018	arginyl-trna synthetase
I6H71_RS04995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H71_RS05000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS05005	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6H71_RS05010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H71_RS05050	COG0582	viral genome integration into host DNA
I6H71_RS05055	COG2111	Na H antiporter
I6H71_RS05055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H71_RS05060	COG2111	Na H antiporter
I6H71_RS05065	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H71_RS05075	COG1863	multisubunit Na H antiporter MnhE subunit
I6H71_RS05080	COG2212	antiporter activity
I6H71_RS05085	COG1320	monovalent cation:proton antiporter activity
I6H71_RS05090	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H71_RS05095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H71_RS05100	COG1121	(ABC) transporter
I6H71_RS05120	COG1134	teichoic acid transport
I6H71_RS05125	COG1682	transport, permease protein
I6H71_RS05130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H71_RS05135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H71_RS05145	COG1132	(ABC) transporter
I6H71_RS05165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H71_RS05170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H71_RS05175	COG1120	ATPase activity
I6H71_RS05180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS05185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS05195	COG3344	reverse transcriptase
I6H71_RS05200	COG0477	Major facilitator Superfamily
I6H71_RS05210	COG0657	acetylesterase activity
I6H71_RS05220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H71_RS05225	COG0745	RESPONSE REGULATOR receiver
I6H71_RS05235	COG1136	(ABC) transporter
I6H71_RS05240	COG0577	efflux transmembrane transporter activity
I6H71_RS05245	COG1392	Phosphate transport regulator
I6H71_RS05250	COG0306	phosphate transporter
I6H71_RS05260	COG1388	LysM domain
I6H71_RS05260	COG3942	CHAP domain
I6H71_RS05280	COG2022	thiamine diphosphate biosynthetic process
I6H71_RS05290	COG0217	transcriptional regulatory protein
I6H71_RS05300	COG0583	DNA-binding transcription factor activity
I6H71_RS05305	COG2814	Major facilitator Superfamily
I6H71_RS05310	COG2839	Protein conserved in bacteria
I6H71_RS05340	COG1611	Belongs to the LOG family
I6H71_RS05345	COG1671	Belongs to the UPF0178 family
I6H71_RS05355	COG1968	undecaprenyl-diphosphatase activity
I6H71_RS05360	COG4988	ABC transporter
I6H71_RS05365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H71_RS05375	COG0523	cobalamin synthesis protein
I6H71_RS05380	COG4989	oxidoreductase activity
I6H71_RS05390	COG0039	L-malate dehydrogenase activity
I6H71_RS05410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H71_RS05410	COG0463	Glycosyl transferase, family 2
I6H71_RS05415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H71_RS05420	COG1349	DNA-binding transcription factor activity
I6H71_RS05425	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H71_RS05430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H71_RS05430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H71_RS05430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H71_RS05435	COG1253	flavin adenine dinucleotide binding
I6H71_RS05440	COG0463	Glycosyl transferase, family 2
I6H71_RS05465	COG0720	synthase
I6H71_RS05470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H71_RS05475	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H71_RS05505	COG1368	sulfuric ester hydrolase activity
I6H71_RS05515	COG0488	(ABC) transporter
I6H71_RS05520	COG0514	ATP-dependent DNA helicase (RecQ)
I6H71_RS05530	COG1174	glycine betaine transport
I6H71_RS05540	COG1131	(ABC) transporter
I6H71_RS05545	COG0842	Transport permease protein
I6H71_RS05550	COG2203	Gaf domain
I6H71_RS05550	COG4585	Histidine kinase
I6H71_RS05555	COG2197	response regulator
I6H71_RS05570	COG3104	oligopeptide transport
I6H71_RS05575	COG3104	oligopeptide transport
I6H71_RS05580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H71_RS05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H71_RS05600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H71_RS05610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H71_RS05625	COG3118	belongs to the thioredoxin family
I6H71_RS05635	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H71_RS05655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H71_RS05660	COG1739	Uncharacterized protein family UPF0029
I6H71_RS05670	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H71_RS05675	COG1040	competence protein
I6H71_RS05680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H71_RS05685	COG0653	protein targeting
I6H71_RS05725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H71_RS05730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H71_RS05735	COG0110	maltose O-acetyltransferase activity
I6H71_RS05745	COG0492	ferredoxin-NADP+ reductase activity
I6H71_RS05750	COG1660	Displays ATPase and GTPase activities
I6H71_RS05755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H71_RS05760	COG1481	regulation of sporulation
I6H71_RS05795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H71_RS05810	COG1302	Protein conserved in bacteria
I6H71_RS05825	COG2801	Transposase and inactivated derivatives
I6H71_RS05835	COG0740	serine-type endopeptidase activity
I6H71_RS05845	COG1278	Cold shock
I6H71_RS05850	COG3844	kynureninase activity
I6H71_RS05905	COG0126	phosphoglycerate kinase activity
I6H71_RS05910	COG0149	triose-phosphate isomerase activity
I6H71_RS05915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6H71_RS05920	COG0148	phosphopyruvate hydratase activity
I6H71_RS05930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H71_RS05935	COG1647	Serine aminopeptidase, S33
I6H71_RS05940	COG0557	exoribonuclease II activity
I6H71_RS05945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H71_RS05990	COG0346	lactoylglutathione lyase activity
I6H71_RS06000	COG1518	maintenance of DNA repeat elements
I6H71_RS06020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H71_RS06055	COG2814	Major facilitator Superfamily
I6H71_RS06065	COG2814	Major facilitator Superfamily
I6H71_RS06070	COG4264	IucA IucC family
I6H71_RS06075	COG3457	Alanine racemase
I6H71_RS06080	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6H71_RS06085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS06090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H71_RS06095	COG3314	Sporulation integral membrane protein YlbJ
I6H71_RS06105	COG1988	membrane-bound metal-dependent
I6H71_RS06110	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6H71_RS06115	COG1272	protein, Hemolysin III
I6H71_RS06130	COG2814	Major facilitator Superfamily
I6H71_RS06135	COG0489	protein tyrosine kinase activity
I6H71_RS06195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H71_RS06200	COG2801	Transposase and inactivated derivatives
I6H71_RS06210	COG0246	Mannitol dehydrogenase
I6H71_RS06220	COG3711	transcriptional antiterminator
I6H71_RS06235	COG3344	reverse transcriptase
I6H71_RS06240	COG1119	ATPase activity
I6H71_RS06255	COG2186	Transcriptional regulator
I6H71_RS06260	COG1482	cell wall glycoprotein biosynthetic process
I6H71_RS06275	COG1757	Na H antiporter
I6H71_RS06290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H71_RS06320	COG5146	pantothenate kinase activity
I6H71_RS06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H71_RS06345	COG4821	SIS domain
I6H71_RS06350	COG0191	fructose-bisphosphate aldolase activity
I6H71_RS06355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H71_RS06360	COG1733	regulation of RNA biosynthetic process
I6H71_RS06365	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS06370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H71_RS06375	COG0254	rRNA binding
I6H71_RS06380	COG1435	thymidine kinase activity
I6H71_RS06385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H71_RS06390	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H71_RS06395	COG0009	L-threonylcarbamoyladenylate synthase
I6H71_RS06400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H71_RS06405	COG4475	Protein of unknown function (DUF436)
I6H71_RS06410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H71_RS06415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H71_RS06420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6H71_RS06430	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H71_RS06435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H71_RS06440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H71_RS06445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H71_RS06455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H71_RS06460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H71_RS06465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H71_RS06470	COG4836	Membrane
I6H71_RS06475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H71_RS06500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H71_RS06510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H71_RS06515	COG0352	thiamine-phosphate diphosphorylase activity
I6H71_RS06520	COG0706	membrane insertase activity
I6H71_RS06525	COG1418	mRNA catabolic process
I6H71_RS06535	COG1937	Protein conserved in bacteria
I6H71_RS06545	COG2608	mercury ion transmembrane transporter activity
I6H71_RS06550	COG2217	Heavy metal translocating P-type atpase
I6H71_RS06560	COG0772	Belongs to the SEDS family
I6H71_RS06565	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H71_RS06570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H71_RS06575	COG0513	Belongs to the DEAD box helicase family
I6H71_RS06595	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H71_RS06610	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H71_RS06615	COG2208	phosphoserine phosphatase activity
I6H71_RS06620	COG1366	Belongs to the anti-sigma-factor antagonist family
I6H71_RS06630	COG1191	sigma factor activity
I6H71_RS06635	COG2183	response to ionizing radiation
I6H71_RS06640	COG3091	SprT-like family
I6H71_RS06670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H71_RS06675	COG0066	3-isopropylmalate dehydratase activity
I6H71_RS06680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H71_RS06685	COG0473	3-isopropylmalate dehydrogenase activity
I6H71_RS06690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H71_RS06695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H71_RS06705	COG0028	Belongs to the TPP enzyme family
I6H71_RS06710	COG0129	dihydroxy-acid dehydratase activity
I6H71_RS06715	COG0802	atpase or kinase
I6H71_RS06720	COG1214	PFAM Peptidase M22, glycoprotease
I6H71_RS06725	COG0456	acetyltransferase
I6H71_RS06730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H71_RS06735	COG0488	(ABC) transporter
I6H71_RS06740	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6H71_RS06745	COG2391	methyltransferase activity
I6H71_RS06750	COG0425	Belongs to the sulfur carrier protein TusA family
I6H71_RS06755	COG1621	beta-fructofuranosidase activity
I6H71_RS06775	COG4512	PFAM Accessory gene regulator B
I6H71_RS06800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H71_RS06845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H71_RS06850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H71_RS06860	COG0436	Aminotransferase
I6H71_RS06875	COG1725	Transcriptional regulator
I6H71_RS06880	COG1131	(ABC) transporter
I6H71_RS06890	COG1131	(ABC) transporter
I6H71_RS06900	COG1802	Transcriptional regulator
I6H71_RS06910	COG2610	gluconate transmembrane transporter activity
I6H71_RS06950	COG2706	6-phosphogluconolactonase activity
I6H71_RS06955	COG1012	belongs to the aldehyde dehydrogenase family
I6H71_RS06965	COG1227	inorganic diphosphatase activity
I6H71_RS06970	COG1335	isochorismatase
I6H71_RS06980	COG0077	Prephenate dehydratase
I6H71_RS06990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H71_RS06995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H71_RS07000	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6H71_RS07015	COG4496	protein, YerC YecD
I6H71_RS07020	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6H71_RS07025	COG0210	DNA helicase
I6H71_RS07030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H71_RS07035	COG4851	CamS sex pheromone cAM373 precursor
I6H71_RS07040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H71_RS07045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H71_RS07055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H71_RS07060	COG1597	lipid kinase activity
I6H71_RS07070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H71_RS07080	COG1528	Iron-storage protein
I6H71_RS07095	COG4129	membrane
I6H71_RS07100	COG0024	Methionine aminopeptidase
I6H71_RS07120	COG2197	response regulator
I6H71_RS07125	COG0288	reversible hydration of carbon dioxide
I6H71_RS07130	COG1295	ribonuclease BN
I6H71_RS07140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H71_RS07145	COG4840	Belongs to the UPF0435 family
I6H71_RS07150	COG2309	aminopeptidase activity
I6H71_RS07155	COG1607	acyl-coa hydrolase
I6H71_RS07160	COG0535	radical SAM domain protein
I6H71_RS07170	COG0693	protein deglycase activity
I6H71_RS07175	COG2348	transferase activity, transferring amino-acyl groups
I6H71_RS07180	COG0028	Belongs to the TPP enzyme family
I6H71_RS07185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H71_RS07190	COG2137	regulation of response to DNA damage stimulus
I6H71_RS07200	COG1388	LysM domain
I6H71_RS07200	COG1134	teichoic acid transport
I6H71_RS07210	COG1988	membrane-bound metal-dependent
I6H71_RS07220	COG3557	Belongs to the UPF0374 family
I6H71_RS07230	COG0069	glutamate synthase activity
I6H71_RS07235	COG4129	membrane
I6H71_RS07240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H71_RS07245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H71_RS07250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H71_RS07255	COG0735	belongs to the Fur family
I6H71_RS07400	COG4974	Belongs to the 'phage' integrase family
I6H71_RS07480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H71_RS07480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H71_RS07520	COG1780	Probably involved in ribonucleotide reductase function
I6H71_RS07530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H71_RS07535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H71_RS07550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H71_RS07575	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6H71_RS07795	COG0765	amino acid transport
I6H71_RS07800	COG1126	abc transporter atp-binding protein
I6H71_RS07805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H71_RS07815	COG0363	glucosamine-6-phosphate deaminase activity
I6H71_RS07840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6H71_RS07845	COG0564	pseudouridine synthase activity
I6H71_RS07850	COG2203	Gaf domain
I6H71_RS07850	COG4585	Histidine kinase
I6H71_RS07855	COG2197	response regulator
I6H71_RS07860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H71_RS07875	COG4399	Belongs to the UPF0754 family
I6H71_RS07880	COG3679	Belongs to the UPF0342 family
I6H71_RS07885	COG0420	3'-5' exonuclease activity
I6H71_RS07890	COG4717	serine-type aminopeptidase activity
I6H71_RS07900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H71_RS07910	COG1846	Transcriptional regulator
I6H71_RS07920	COG0537	adenosine 5'-monophosphoramidase activity
I6H71_RS07925	COG1131	(ABC) transporter
I6H71_RS07930	COG4473	ABC transporter
I6H71_RS07935	COG3344	reverse transcriptase
I6H71_RS07945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H71_RS07950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H71_RS07955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6H71_RS08030	COG0318	PFAM AMP-dependent synthetase and ligase
I6H71_RS08040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H71_RS08050	COG1506	peptidase
I6H71_RS08055	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6H71_RS08060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H71_RS08070	COG0656	L-ascorbic acid biosynthetic process
I6H71_RS08075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H71_RS08080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H71_RS08090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H71_RS08110	COG1595	DNA-templated transcription, initiation
I6H71_RS08120	COG3266	domain, Protein
I6H71_RS08120	COG4193	domain, Protein
I6H71_RS08120	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6H71_RS08130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H71_RS08130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H71_RS08135	COG0307	riboflavin synthase, alpha
I6H71_RS08140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H71_RS08140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H71_RS08145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H71_RS08150	COG0506	proline dehydrogenase activity
I6H71_RS08160	COG2267	carboxylic ester hydrolase activity
I6H71_RS08165	COG0039	L-malate dehydrogenase activity
I6H71_RS08175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H71_RS08180	COG1242	4 iron, 4 sulfur cluster binding
I6H71_RS08190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H71_RS08195	COG2081	HI0933 family
I6H71_RS08200	COG2244	polysaccharide biosynthetic process
I6H71_RS08205	COG1187	pseudouridine synthase activity
I6H71_RS08215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H71_RS08220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H71_RS08225	COG0510	thiamine kinase activity
I6H71_RS08230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H71_RS08235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H71_RS08245	COG1363	Peptidase, m42
I6H71_RS08250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H71_RS08260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H71_RS08265	COG1674	ftsk spoiiie
I6H71_RS08270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H71_RS08275	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6H71_RS08285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H71_RS08285	COG1605	Chorismate mutase
I6H71_RS08295	COG1609	Transcriptional regulator
I6H71_RS08300	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6H71_RS08305	COG0454	-acetyltransferase
I6H71_RS08310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H71_RS08315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H71_RS08320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6H71_RS08330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H71_RS08335	COG0204	Acyl-transferase
I6H71_RS08345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H71_RS08360	COG0584	glycerophosphoryl diester phosphodiesterase
I6H71_RS08370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H71_RS08375	COG1956	GAF domain-containing protein
I6H71_RS08380	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6H71_RS08385	COG1104	cysteine desulfurase activity
I6H71_RS08390	COG0301	tRNA thio-modification
I6H71_RS08395	COG0616	signal peptide processing
I6H71_RS08400	COG1714	RDD family
I6H71_RS08410	COG0827	DNA restriction-modification system
I6H71_RS08415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H71_RS08420	COG0589	response to stress
I6H71_RS08445	COG4109	DRTGG domain
I6H71_RS08450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H71_RS08455	COG0587	DNA-directed DNA polymerase activity
I6H71_RS08460	COG0281	malic enzyme
I6H71_RS08465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H71_RS08470	COG0825	malonyl-CoA metabolic process
I6H71_RS08475	COG0205	6-phosphofructokinase activity
I6H71_RS08480	COG0469	pyruvate kinase activity
I6H71_RS08485	COG0372	Belongs to the citrate synthase family
I6H71_RS08490	COG0538	isocitrate dehydrogenase activity
I6H71_RS08495	COG0745	RESPONSE REGULATOR receiver
I6H71_RS08500	COG5002	protein histidine kinase activity
I6H71_RS08505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H71_RS08505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H71_RS08510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H71_RS08515	COG0237	dephospho-CoA kinase activity
I6H71_RS08520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H71_RS08530	COG3611	Membrane attachment protein
I6H71_RS08535	COG1484	DNA-dependent DNA replication
I6H71_RS08545	COG0833	amino acid
I6H71_RS08550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H71_RS08555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H71_RS08565	COG4112	unkown
I6H71_RS08575	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H71_RS08580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H71_RS08585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H71_RS08595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H71_RS08600	COG0181	hydroxymethylbilane synthase activity
I6H71_RS08615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H71_RS08620	COG3180	Ammonia monooxygenase
I6H71_RS08625	COG0525	valine-tRNA ligase activity
I6H71_RS08630	COG0285	dihydrofolate synthase activity
I6H71_RS08640	COG2003	Belongs to the UPF0758 family
I6H71_RS08685	COG2003	Belongs to the UPF0758 family
I6H71_RS08700	COG1792	Involved in formation and maintenance of cell shape
I6H71_RS08715	COG2868	ribosomal protein
I6H71_RS08725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H71_RS08730	COG4492	Belongs to the UPF0735 family
I6H71_RS08735	COG0632	four-way junction helicase activity
I6H71_RS08740	COG2255	four-way junction helicase activity
I6H71_RS08745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H71_RS08750	COG0343	queuine tRNA-ribosyltransferase activity
I6H71_RS08755	COG1862	Preprotein translocase
I6H71_RS08760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H71_RS08760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H71_RS08765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H71_RS08765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H71_RS08775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H71_RS08780	COG1490	D-aminoacyl-tRNA deacylase activity
I6H71_RS08785	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H71_RS08795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H71_RS08805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H71_RS08810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H71_RS08815	COG1959	2 iron, 2 sulfur cluster binding
I6H71_RS08825	COG3237	CsbD-like
I6H71_RS08835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H71_RS08840	COG1104	cysteine desulfurase activity
I6H71_RS08845	COG0482	sulfurtransferase activity
I6H71_RS08855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H71_RS08860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H71_RS08865	COG4472	Bacterial protein of unknown function (DUF965)
I6H71_RS08870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H71_RS08875	COG3906	Belongs to the UPF0473 family
I6H71_RS08880	COG4122	O-methyltransferase activity
I6H71_RS08885	COG0826	peptidase U32
I6H71_RS08890	COG0826	peptidase U32
I6H71_RS08895	COG0572	uridine kinase
I6H71_RS08900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H71_RS08905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6H71_RS08910	COG1984	allophanate hydrolase subunit 2
I6H71_RS08915	COG0511	ligase activity, forming carbon-carbon bonds
I6H71_RS08920	COG0439	Biotin carboxylase
I6H71_RS08925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6H71_RS08930	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H71_RS08935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H71_RS08940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H71_RS08945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H71_RS08950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H71_RS08955	COG1534	Rna-binding protein
I6H71_RS08960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H71_RS08965	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H71_RS08970	COG0799	negative regulation of ribosome biogenesis
I6H71_RS08980	COG1555	photosystem II stabilization
I6H71_RS08985	COG2131	deaminase
I6H71_RS08990	COG2333	competence protein COMEC
I6H71_RS08990	COG0658	competence protein
I6H71_RS09000	COG0268	Binds directly to 16S ribosomal RNA
I6H71_RS09005	COG0481	GTPase activity
I6H71_RS09010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H71_RS09015	COG1420	regulation of RNA biosynthetic process
I6H71_RS09020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H71_RS09025	COG0443	Heat shock 70 kDa protein
I6H71_RS09030	COG0484	heat shock protein binding
I6H71_RS09035	COG2264	protein methyltransferase activity
I6H71_RS09040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H71_RS09045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H71_RS09055	COG1030	water channel activity
I6H71_RS09060	COG4864	UPF0365 protein
I6H71_RS09070	COG1702	phosphate starvation-inducible protein PhoH
I6H71_RS09075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H71_RS09080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H71_RS09090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H71_RS09105	COG0423	glycine-tRNA ligase activity
I6H71_RS09110	COG0517	IMP dehydrogenase activity
I6H71_RS09115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H71_RS09120	COG0358	DNA primase activity
I6H71_RS09125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H71_RS09130	COG2384	SAM-dependent methyltransferase
I6H71_RS09135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H71_RS09140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H71_RS09145	COG0513	Belongs to the DEAD box helicase family
I6H71_RS09150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6H71_RS09155	COG1121	(ABC) transporter
I6H71_RS09160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H71_RS09170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H71_RS09180	COG0768	penicillin binding
I6H71_RS09185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H71_RS09190	COG0573	inorganic phosphate transmembrane transporter activity
I6H71_RS09195	COG0581	inorganic phosphate transmembrane transporter activity
I6H71_RS09200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H71_RS09205	COG0704	Plays a role in the regulation of phosphate uptake
I6H71_RS09210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H71_RS09215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H71_RS09220	COG0705	Rhomboid family
I6H71_RS09225	COG4483	Protein conserved in bacteria
I6H71_RS09230	COG1940	carbohydrate kinase activity
I6H71_RS09235	COG0011	TIGRFAM Protein of
I6H71_RS09240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H71_RS09245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H71_RS09255	COG4537	Required for transformation and DNA binding
I6H71_RS09270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H71_RS09275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6H71_RS09285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6H71_RS09290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H71_RS09295	COG0095	Lipoate-protein ligase
I6H71_RS09310	COG0006	proline dipeptidase activity
I6H71_RS09315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H71_RS09320	COG0511	ligase activity, forming carbon-carbon bonds
I6H71_RS09325	COG0439	Biotin carboxylase
I6H71_RS09330	COG1302	Protein conserved in bacteria
I6H71_RS09335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H71_RS09340	COG1570	exodeoxyribonuclease VII activity
I6H71_RS09350	COG0142	geranyltranstransferase activity
I6H71_RS09355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H71_RS09365	COG0497	DNA recombination
I6H71_RS09370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H71_RS09375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H71_RS09380	COG0022	dehydrogenase e1 component
I6H71_RS09385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H71_RS09395	COG4129	membrane
I6H71_RS09405	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H71_RS09420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H71_RS09425	COG1234	tRNA 3'-trailer cleavage
I6H71_RS09430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H71_RS09435	COG0667	Aldo Keto reductase
I6H71_RS09440	COG0494	nUDIX hydrolase
I6H71_RS09445	COG0735	belongs to the Fur family
I6H71_RS09450	COG4974	Belongs to the 'phage' integrase family
I6H71_RS09460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H71_RS09465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H71_RS09470	COG1187	pseudouridine synthase activity
I6H71_RS09475	COG0745	RESPONSE REGULATOR receiver
I6H71_RS09480	COG5002	protein histidine kinase activity
I6H71_RS09495	COG1141	Ferredoxin
I6H71_RS09505	COG0514	ATP-dependent DNA helicase (RecQ)
I6H71_RS09515	COG0492	ferredoxin-NADP+ reductase activity
I6H71_RS09520	COG0252	asparaginase activity
I6H71_RS09525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H71_RS09530	COG0539	negative regulation of cytoplasmic translation
I6H71_RS09535	COG1160	GTP binding
I6H71_RS09540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H71_RS09555	COG2226	methyltransferase
I6H71_RS09560	COG0142	geranyltranstransferase activity
I6H71_RS09565	COG0105	UTP biosynthetic process
I6H71_RS09575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H71_RS09585	COG0457	Tetratricopeptide repeat
I6H71_RS09595	COG4347	Protein of unknown function (DUF1405)
I6H71_RS09600	COG2738	Putative neutral zinc metallopeptidase
I6H71_RS09605	COG1694	Mazg nucleotide pyrophosphohydrolase
I6H71_RS09610	COG0438	transferase activity, transferring glycosyl groups
I6H71_RS09615	COG0617	tRNA 3'-terminal CCA addition
I6H71_RS09625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H71_RS09625	COG1199	ATP-dependent helicase activity
I6H71_RS09630	COG0017	Asparaginyl-tRNA synthetase
I6H71_RS09635	COG3935	DnaD domain protein
I6H71_RS09640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H71_RS09650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H71_RS09650	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6H71_RS09665	COG4474	Belongs to the UPF0398 family
I6H71_RS09670	COG3599	regulation of cell shape
I6H71_RS09680	COG0116	Belongs to the methyltransferase superfamily
I6H71_RS09685	COG2962	Rard protein
I6H71_RS09690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6H71_RS09695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H71_RS09700	COG0328	RNA-DNA hybrid ribonuclease activity
I6H71_RS09705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6H71_RS09715	COG1413	lyase activity
I6H71_RS09745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H71_RS09760	COG0793	Belongs to the peptidase S41A family
I6H71_RS09770	COG0671	phosphoesterase, PA-phosphatase related
I6H71_RS09780	COG5002	protein histidine kinase activity
I6H71_RS09790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H71_RS09810	COG0714	Associated with various cellular activities
I6H71_RS09815	COG4548	von Willebrand factor, type A
I6H71_RS09820	COG1114	Component of the transport system for branched-chain amino acids
I6H71_RS09825	COG3853	Toxic anion resistance protein (TelA)
I6H71_RS09845	COG1278	Cold shock
I6H71_RS09865	COG2171	N-acyltransferase activity
I6H71_RS09870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H71_RS09875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H71_RS09880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H71_RS09885	COG0488	(ABC) transporter
I6H71_RS09890	COG2996	Protein conserved in bacteria
I6H71_RS09905	COG2348	transferase activity, transferring amino-acyl groups
I6H71_RS09910	COG2348	transferase activity, transferring amino-acyl groups
I6H71_RS09915	COG0287	Prephenate dehydrogenase
I6H71_RS09920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H71_RS09940	COG0628	permease
I6H71_RS09945	COG3711	transcriptional antiterminator
I6H71_RS09950	COG1115	amino acid carrier protein
I6H71_RS09955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H71_RS09965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H71_RS09970	COG4841	protein insertion into membrane
I6H71_RS09975	COG0824	Thioesterase
I6H71_RS09985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H71_RS09990	COG1970	mechanosensitive ion channel activity
I6H71_RS10000	COG2801	Transposase and inactivated derivatives
I6H71_RS10005	COG0419	ATPase involved in DNA repair
I6H71_RS10010	COG0420	3'-5' exonuclease activity
I6H71_RS10020	COG4846	Membrane protein involved in cytochrome C biogenesis
I6H71_RS10025	COG3763	UPF0154 protein
I6H71_RS10035	COG4224	UPF0291 protein
I6H71_RS10055	COG0516	GMP reductase activity
I6H71_RS10060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H71_RS10070	COG0753	catalase activity
I6H71_RS10075	COG0833	amino acid
I6H71_RS10085	COG0561	phosphatase activity
I6H71_RS10090	COG0083	homoserine kinase activity
I6H71_RS10095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H71_RS10100	COG0460	homoserine dehydrogenase
I6H71_RS10105	COG0527	aspartate kinase activity
I6H71_RS10125	COG1525	nuclease
I6H71_RS10155	COG0174	glutamine synthetase
I6H71_RS10160	COG0789	Transcriptional regulator
I6H71_RS10165	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6H71_RS10170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H71_RS10175	COG0386	Belongs to the glutathione peroxidase family
I6H71_RS10180	COG1923	regulation of RNA biosynthetic process
I6H71_RS10185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H71_RS10195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6H71_RS10205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H71_RS10210	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H71_RS10215	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6H71_RS10220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H71_RS10235	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6H71_RS10240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H71_RS10250	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H71_RS10255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H71_RS10255	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H71_RS10260	COG1692	metallophosphoesterase
I6H71_RS10280	COG1418	mRNA catabolic process
I6H71_RS10285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H71_RS10290	COG1546	Belongs to the CinA family
I6H71_RS10290	COG1058	Belongs to the CinA family
I6H71_RS10315	COG0612	Peptidase, M16
I6H71_RS10320	COG0612	Peptidase, M16
I6H71_RS10325	COG2188	Transcriptional regulator
I6H71_RS10340	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H71_RS10350	COG0196	riboflavin kinase activity
I6H71_RS10355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H71_RS10360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H71_RS10365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H71_RS10370	COG1358	cellular component organization or biogenesis
I6H71_RS10375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H71_RS10380	COG0195	Participates in both transcription termination and antitermination
I6H71_RS10385	COG0779	Required for maturation of 30S ribosomal subunits
I6H71_RS10390	COG2176	DNA-directed DNA polymerase activity
I6H71_RS10395	COG0442	prolyl-tRNA aminoacylation
I6H71_RS10405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6H71_RS10410	COG4589	Belongs to the CDS family
I6H71_RS10420	COG0233	cytoplasmic translational termination
I6H71_RS10425	COG0528	UMP kinase activity
I6H71_RS10435	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H71_RS10440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6H71_RS10445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6H71_RS10455	COG4974	Belongs to the 'phage' integrase family
I6H71_RS10465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H71_RS10470	COG0758	DNA mediated transformation
I6H71_RS10480	COG0045	succinate-CoA ligase (ADP-forming) activity
I6H71_RS10495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H71_RS10510	COG4485	Bacterial membrane protein, YfhO
I6H71_RS10525	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H71_RS10530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H71_RS10535	COG0228	four-way junction DNA binding
I6H71_RS10540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H71_RS10545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H71_RS10550	COG0552	protein localization to endoplasmic reticulum
I6H71_RS10555	COG1196	nuclear chromosome segregation
I6H71_RS10560	COG0571	ribonuclease III activity
I6H71_RS10565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H71_RS10585	COG1349	DNA-binding transcription factor activity
I6H71_RS10595	COG1760	l-serine dehydratase
I6H71_RS10600	COG1760	l-serine dehydratase
I6H71_RS10610	COG1302	Protein conserved in bacteria
I6H71_RS10625	COG2801	Transposase and inactivated derivatives
I6H71_RS10635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H71_RS10640	COG1162	GTPase activity
I6H71_RS10645	COG2124	cytochrome p450
I6H71_RS10655	COG0631	protein serine/threonine phosphatase activity
I6H71_RS10660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H71_RS10665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H71_RS10665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H71_RS10670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H71_RS10680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H71_RS10685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H71_RS10690	COG1758	RNA polymerase activity
I6H71_RS10700	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H71_RS10710	COG0546	phosphoglycolate phosphatase activity
I6H71_RS10720	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H71_RS10725	COG0167	dihydroorotate dehydrogenase activity
I6H71_RS10730	COG0543	2 iron, 2 sulfur cluster binding
I6H71_RS10735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H71_RS10740	COG0505	Belongs to the CarA family
I6H71_RS10750	COG0540	Belongs to the ATCase OTCase family
I6H71_RS10760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H71_RS10765	COG0564	pseudouridine synthase activity
I6H71_RS10770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H71_RS10775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H71_RS10780	COG3599	regulation of cell shape
I6H71_RS10790	COG0762	integral membrane protein
I6H71_RS10795	COG1799	cell septum assembly
I6H71_RS10800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H71_RS10810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H71_RS10815	COG0849	cell division
I6H71_RS10825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H71_RS10835	COG0768	penicillin binding
I6H71_RS10840	COG4839	cell division protein FtsL
I6H71_RS10845	COG0275	rRNA processing
I6H71_RS10850	COG2001	Belongs to the MraZ family
I6H71_RS10855	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6H71_RS10860	COG0454	-acetyltransferase
I6H71_RS10865	COG1011	Hydrolase
I6H71_RS10895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H71_RS10920	COG0577	efflux transmembrane transporter activity
I6H71_RS10920	COG1136	(ABC) transporter
I6H71_RS10935	COG1131	(ABC) transporter
I6H71_RS10945	COG0733	neurotransmitter:sodium symporter activity
I6H71_RS10965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H71_RS10970	COG1053	succinate dehydrogenase
I6H71_RS10975	COG2009	succinate dehydrogenase
I6H71_RS10980	COG0322	excinuclease ABC activity
I6H71_RS10985	COG3118	belongs to the thioredoxin family
I6H71_RS10995	COG1796	DNA polymerase
I6H71_RS10995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6H71_RS11010	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H71_RS11015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H71_RS11015	COG0072	phenylalanine-tRNA ligase activity
I6H71_RS11020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H71_RS11025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H71_RS11030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H71_RS11045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H71_RS11050	COG0742	ribosomal rna small subunit methyltransferase
I6H71_RS11060	COG4471	UPF0298 protein
I6H71_RS11065	COG0584	glycerophosphoryl diester phosphodiesterase
I6H71_RS11070	COG3679	Belongs to the UPF0342 family
I6H71_RS11085	COG0109	protoheme IX farnesyltransferase activity
I6H71_RS11090	COG1612	heme a metabolic process
I6H71_RS11100	COG0772	Belongs to the SEDS family
I6H71_RS11105	COG4838	Belongs to the UPF0358 family
I6H71_RS11110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6H71_RS11115	COG4896	Protein conserved in bacteria
I6H71_RS11120	COG1902	pentaerythritol trinitrate reductase activity
I6H71_RS11125	COG1217	gtp-binding protein TYPA
I6H71_RS11135	COG0483	inositol monophosphate 1-phosphatase activity
I6H71_RS11165	COG1177	transmembrane transport
I6H71_RS11170	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H71_RS11185	COG4476	Belongs to the UPF0223 family
I6H71_RS11215	COG0242	peptide deformylase activity
I6H71_RS11235	COG0569	domain protein
I6H71_RS11240	COG1294	oxidase, subunit
I6H71_RS11245	COG1271	oxidase subunit
I6H71_RS11280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H71_RS11290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H71_RS11310	COG1122	ATPase activity
I6H71_RS11320	COG0151	Belongs to the GarS family
I6H71_RS11325	COG0138	bifunctional purine biosynthesis protein purh
I6H71_RS11335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H71_RS11340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H71_RS11345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H71_RS11355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H71_RS11360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H71_RS11365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H71_RS11370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H71_RS11375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H71_RS11385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H71_RS11385	COG1017	nitric oxide dioxygenase activity
I6H71_RS11395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6H71_RS11405	COG1845	cytochrome c oxidase, subunit III
I6H71_RS11410	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6H71_RS11425	COG1134	teichoic acid transport
I6H71_RS11445	COG0438	transferase activity, transferring glycosyl groups
I6H71_RS11450	COG0463	Glycosyl transferase, family 2
I6H71_RS11470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H71_RS11475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H71_RS11480	COG1316	TRANSCRIPTIONal
I6H71_RS11505	COG3594	Acyltransferase
I6H71_RS11510	COG0436	Aminotransferase
I6H71_RS11515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H71_RS11520	COG2267	carboxylic ester hydrolase activity
I6H71_RS11525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H71_RS11530	COG1169	isochorismate synthase
I6H71_RS11540	COG1575	Belongs to the MenA family. Type 1 subfamily
I6H71_RS11545	COG0390	transport system, permease component
I6H71_RS11550	COG4619	ABC transporter
I6H71_RS11555	COG0456	acetyltransferase
I6H71_RS11595	COG2801	Transposase and inactivated derivatives
I6H71_RS11655	COG4873	Protein conserved in bacteria
I6H71_RS11665	COG0737	Belongs to the 5'-nucleotidase family
I6H71_RS11670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H71_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H71_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H71_RS11680	COG0861	Integral membrane protein TerC family
I6H71_RS11695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H71_RS11700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H71_RS11705	COG2814	Major facilitator Superfamily
I6H71_RS11710	COG3119	arylsulfatase activity
I6H71_RS11715	COG3715	PTS system
I6H71_RS11720	COG3716	PTS system mannose fructose sorbose family IID component
I6H71_RS11725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6H71_RS11730	COG2382	esterase
I6H71_RS11735	COG1115	amino acid carrier protein
I6H71_RS11740	COG0628	permease
I6H71_RS11750	COG0475	glutathione-regulated potassium exporter activity
I6H71_RS11750	COG0569	domain protein
I6H71_RS11755	COG2239	Acts as a magnesium transporter
I6H71_RS11760	COG0564	pseudouridine synthase activity
I6H71_RS11765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H71_RS11770	COG2357	RelA SpoT domain protein
I6H71_RS11780	COG4116	CYTH
I6H71_RS11785	COG2346	COG2346, Truncated hemoglobins
I6H71_RS11800	COG1164	Oligoendopeptidase f
I6H71_RS11815	COG1393	Belongs to the ArsC family
I6H71_RS11825	COG4166	transmembrane transport
I6H71_RS11830	COG4608	Belongs to the ABC transporter superfamily
I6H71_RS11835	COG0444	Belongs to the ABC transporter superfamily
I6H71_RS11840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H71_RS11845	COG0601	transmembrane transport