locus-tag	class	description
CUZ62_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CUZ62_RS00010	COG0592	DNA-directed DNA polymerase activity
CUZ62_RS00015	COG2501	S4 domain
CUZ62_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUZ62_RS00025	COG0187	DNA topoisomerase II activity
CUZ62_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CUZ62_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CUZ62_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CUZ62_RS00045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CUZ62_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CUZ62_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CUZ62_RS00070	COG0359	binds to the 23S rRNA
CUZ62_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
CUZ62_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CUZ62_RS00095	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS00100	COG5002	protein histidine kinase activity
CUZ62_RS00105	COG4863	YycH protein
CUZ62_RS00115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CUZ62_RS00120	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CUZ62_RS00170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUZ62_RS00210	COG0640	Transcriptional regulator
CUZ62_RS00220	COG2217	Heavy metal translocating P-type atpase
CUZ62_RS00225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUZ62_RS00230	COG2210	Belongs to the sulfur carrier protein TusA family
CUZ62_RS00235	COG1937	Protein conserved in bacteria
CUZ62_RS00240	COG0730	response to heat
CUZ62_RS00250	COG1388	LysM domain
CUZ62_RS00255	COG1397	ADP-ribosylglycohydrolase
CUZ62_RS00265	COG1105	Belongs to the carbohydrate kinase PfkB family
CUZ62_RS00310	COG0640	Transcriptional regulator
CUZ62_RS00315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUZ62_RS00340	COG2030	dehydratase
CUZ62_RS00345	COG0584	glycerophosphoryl diester phosphodiesterase
CUZ62_RS00355	COG3425	synthase
CUZ62_RS00365	COG2217	Heavy metal translocating P-type atpase
CUZ62_RS00370	COG1388	LysM domain
CUZ62_RS00395	COG0789	Transcriptional regulator
CUZ62_RS00405	COG0702	epimerase
CUZ62_RS00410	COG2130	NADP-dependent
CUZ62_RS00425	COG0640	Transcriptional regulator
CUZ62_RS00430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUZ62_RS00435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CUZ62_RS00450	COG0668	transmembrane transport
CUZ62_RS00465	COG0523	cobalamin synthesis protein
CUZ62_RS00470	COG0803	Belongs to the bacterial solute-binding protein 9 family
CUZ62_RS00480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CUZ62_RS00500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUZ62_RS00525	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CUZ62_RS00535	COG0803	Belongs to the bacterial solute-binding protein 9 family
CUZ62_RS00540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CUZ62_RS00545	COG1121	(ABC) transporter
CUZ62_RS00550	COG0523	cobalamin synthesis protein
CUZ62_RS00555	COG1114	Component of the transport system for branched-chain amino acids
CUZ62_RS00570	COG0747	negative chemotaxis
CUZ62_RS00580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUZ62_RS00585	COG4172	Belongs to the ABC transporter superfamily
CUZ62_RS00615	COG0789	Transcriptional regulator
CUZ62_RS00625	COG1253	flavin adenine dinucleotide binding
CUZ62_RS00630	COG1959	2 iron, 2 sulfur cluster binding
CUZ62_RS00635	COG2910	NAD(P)H-binding
CUZ62_RS00660	COG1113	amino acid transport
CUZ62_RS00710	COG1609	Transcriptional regulator
CUZ62_RS00715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUZ62_RS00720	COG1869	D-ribose catabolic process
CUZ62_RS00725	COG1129	ABC transporter
CUZ62_RS00730	COG1172	Belongs to the binding-protein-dependent transport system permease family
CUZ62_RS00735	COG1879	ABC-type sugar transport system periplasmic component
CUZ62_RS00745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CUZ62_RS00750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CUZ62_RS00755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CUZ62_RS00765	COG1876	peptidase activity
CUZ62_RS00770	COG1737	Transcriptional regulator
CUZ62_RS00775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CUZ62_RS00780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CUZ62_RS00785	COG1447	Phosphotransferase system cellobiose-specific component IIA
CUZ62_RS00800	COG2971	BadF BadG BcrA BcrD
CUZ62_RS00810	COG3152	Membrane
CUZ62_RS00820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUZ62_RS00830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CUZ62_RS00835	COG2249	NAD(P)H dehydrogenase (quinone) activity
CUZ62_RS00840	COG1288	antiporter activity
CUZ62_RS00855	COG2318	DinB family
CUZ62_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS00895	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS00900	COG1063	alcohol dehydrogenase
CUZ62_RS00905	COG1846	Transcriptional regulator
CUZ62_RS00910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUZ62_RS00925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CUZ62_RS00935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUZ62_RS00940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CUZ62_RS00945	COG0022	dehydrogenase e1 component
CUZ62_RS00950	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUZ62_RS00955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUZ62_RS00960	COG1695	Transcriptional regulator
CUZ62_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS00975	COG0246	Mannitol dehydrogenase
CUZ62_RS00985	COG3711	transcriptional antiterminator
CUZ62_RS00990	COG2213	PTS system mannitol-specific
CUZ62_RS01005	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CUZ62_RS01010	COG2962	Rard protein
CUZ62_RS01020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CUZ62_RS01035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CUZ62_RS01075	COG0789	Transcriptional regulator
CUZ62_RS01100	COG2314	TM2 domain
CUZ62_RS01110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CUZ62_RS01115	COG0549	Belongs to the carbamate kinase family
CUZ62_RS01125	COG3093	addiction module antidote protein HigA
CUZ62_RS01155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CUZ62_RS01165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CUZ62_RS01175	COG0471	metal ion transport
CUZ62_RS01180	COG5505	Protein of unknown function (DUF819)
CUZ62_RS01185	COG4336	lyase activity
CUZ62_RS01200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CUZ62_RS01210	COG0363	glucosamine-6-phosphate deaminase activity
CUZ62_RS01215	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CUZ62_RS01230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUZ62_RS01235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUZ62_RS01260	COG1124	(ABC) transporter
CUZ62_RS01265	COG0444	Belongs to the ABC transporter superfamily
CUZ62_RS01280	COG0747	negative chemotaxis
CUZ62_RS01285	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CUZ62_RS01305	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CUZ62_RS01315	COG1054	Belongs to the UPF0176 family
CUZ62_RS01320	COG3386	PFAM SMP-30 Gluconolaconase
CUZ62_RS01325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUZ62_RS01345	COG4716	Myosin-crossreactive antigen
CUZ62_RS01365	COG1131	(ABC) transporter
CUZ62_RS01375	COG1476	TRANSCRIPTIONal
CUZ62_RS01380	COG1959	2 iron, 2 sulfur cluster binding
CUZ62_RS01385	COG0697	spore germination
CUZ62_RS01390	COG2814	Major facilitator Superfamily
CUZ62_RS01400	COG0737	Belongs to the 5'-nucleotidase family
CUZ62_RS01410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CUZ62_RS01415	COG3639	organic phosphonate transmembrane transporter activity
CUZ62_RS01440	COG3391	amine dehydrogenase activity
CUZ62_RS01445	COG0201	protein transport
CUZ62_RS01455	COG1073	alpha beta
CUZ62_RS01465	COG0653	protein targeting
CUZ62_RS01480	COG0642	Histidine kinase
CUZ62_RS01485	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS01505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUZ62_RS01525	COG2814	Major facilitator Superfamily
CUZ62_RS01535	COG2113	Glycine betaine
CUZ62_RS01540	COG2409	Drug exporters of the RND superfamily
CUZ62_RS01545	COG0583	DNA-binding transcription factor activity
CUZ62_RS01550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CUZ62_RS01560	COG1288	antiporter activity
CUZ62_RS01565	COG2190	(PTS) system
CUZ62_RS01565	COG1263	PTS System
CUZ62_RS01565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS01570	COG3942	CHAP domain
CUZ62_RS01570	COG1705	Flagellar rod assembly protein muramidase FlgJ
CUZ62_RS01570	COG1705	Flagellar rod assembly protein muramidase FlgJ
CUZ62_RS01570	COG3942	CHAP domain
CUZ62_RS01605	COG2235	arginine
CUZ62_RS01615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CUZ62_RS01640	COG5658	integral membrane protein
CUZ62_RS01650	COG3961	Belongs to the TPP enzyme family
CUZ62_RS01660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CUZ62_RS01700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CUZ62_RS01725	COG0297	glycogen (starch) synthase activity
CUZ62_RS01730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CUZ62_RS01740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CUZ62_RS01745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CUZ62_RS01750	COG1316	TRANSCRIPTIONal
CUZ62_RS01755	COG1785	Belongs to the alkaline phosphatase family
CUZ62_RS01765	COG2205	protein histidine kinase activity
CUZ62_RS01770	COG1136	(ABC) transporter
CUZ62_RS01800	COG0175	sulfate reduction
CUZ62_RS01805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CUZ62_RS01810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CUZ62_RS01825	COG0730	response to heat
CUZ62_RS01830	COG2046	Belongs to the sulfate adenylyltransferase family
CUZ62_RS01835	COG0529	Catalyzes the synthesis of activated sulfate
CUZ62_RS01840	COG2851	Citrate transporter
CUZ62_RS01855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CUZ62_RS01860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CUZ62_RS01865	COG1510	regulation of RNA biosynthetic process
CUZ62_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS01875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CUZ62_RS01885	COG1473	amidohydrolase
CUZ62_RS01895	COG1473	amidohydrolase
CUZ62_RS01910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CUZ62_RS01920	COG0583	DNA-binding transcription factor activity
CUZ62_RS01930	COG0574	Belongs to the PEP-utilizing enzyme family
CUZ62_RS01930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUZ62_RS01935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CUZ62_RS01940	COG0579	oxidoreductase
CUZ62_RS01950	COG2723	6-phospho-beta-galactosidase activity
CUZ62_RS01970	COG3588	fructose-bisphosphate aldolase
CUZ62_RS01975	COG0563	adenylate kinase activity
CUZ62_RS02000	COG1464	Belongs to the NlpA lipoprotein family
CUZ62_RS02010	COG0531	amino acid
CUZ62_RS02015	COG0028	Belongs to the TPP enzyme family
CUZ62_RS02020	COG3527	Alpha-acetolactate decarboxylase
CUZ62_RS02055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUZ62_RS02065	COG0167	dihydroorotate dehydrogenase activity
CUZ62_RS02070	COG3001	Fructosamine kinase
CUZ62_RS02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CUZ62_RS02130	COG0741	lytic transglycosylase activity
CUZ62_RS02140	COG1233	COG1233 Phytoene dehydrogenase and related
CUZ62_RS02145	COG0463	Glycosyl transferase, family 2
CUZ62_RS02150	COG1562	ergosterol biosynthetic process
CUZ62_RS02155	COG1233	COG1233 Phytoene dehydrogenase and related
CUZ62_RS02160	COG0436	Aminotransferase
CUZ62_RS02170	COG2608	mercury ion transmembrane transporter activity
CUZ62_RS02175	COG2217	Heavy metal translocating P-type atpase
CUZ62_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS02190	COG0110	maltose O-acetyltransferase activity
CUZ62_RS02195	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS02215	COG0598	Magnesium transport protein CorA
CUZ62_RS02225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CUZ62_RS02230	COG3425	synthase
CUZ62_RS02245	COG3942	CHAP domain
CUZ62_RS02245	COG1388	LysM domain
CUZ62_RS02255	COG0583	DNA-binding transcription factor activity
CUZ62_RS02265	COG1380	Effector of murein hydrolase LrgA
CUZ62_RS02270	COG1346	cytolysis
CUZ62_RS02275	COG0028	Belongs to the TPP enzyme family
CUZ62_RS02285	COG2190	(PTS) system
CUZ62_RS02285	COG1263	PTS System
CUZ62_RS02285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS02290	COG1063	alcohol dehydrogenase
CUZ62_RS02300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUZ62_RS02305	COG0039	L-malate dehydrogenase activity
CUZ62_RS02315	COG0697	spore germination
CUZ62_RS02325	COG2207	Transcriptional regulator
CUZ62_RS02325	COG1917	Cupin 2, conserved barrel domain protein
CUZ62_RS02335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUZ62_RS02355	COG1070	Carbohydrate kinase
CUZ62_RS02365	COG1760	l-serine dehydratase
CUZ62_RS02370	COG1760	l-serine dehydratase
CUZ62_RS02385	COG3764	Sortase (surface protein transpeptidase)
CUZ62_RS02405	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS02415	COG2514	catechol 2,3-dioxygenase activity
CUZ62_RS02430	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS02435	COG1846	Transcriptional regulator
CUZ62_RS02440	COG0346	lactoylglutathione lyase activity
CUZ62_RS02445	COG0346	lactoylglutathione lyase activity
CUZ62_RS02450	COG0400	carboxylic ester hydrolase activity
CUZ62_RS02455	COG3949	Membrane
CUZ62_RS02465	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CUZ62_RS02470	COG0586	Pfam SNARE associated Golgi protein
CUZ62_RS02480	COG2022	thiamine diphosphate biosynthetic process
CUZ62_RS02485	COG2022	thiamine diphosphate biosynthetic process
CUZ62_RS02485	COG2104	thiamine diphosphate biosynthetic process
CUZ62_RS02490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CUZ62_RS02500	COG2271	Major facilitator Superfamily
CUZ62_RS02515	COG4876	unkown
CUZ62_RS02520	COG2357	RelA SpoT domain protein
CUZ62_RS02535	COG1802	Transcriptional regulator
CUZ62_RS02540	COG1070	Carbohydrate kinase
CUZ62_RS02545	COG2610	gluconate transmembrane transporter activity
CUZ62_RS02555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CUZ62_RS02560	COG0494	nUDIX hydrolase
CUZ62_RS02585	COG4221	oxidoreductase activity
CUZ62_RS02590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUZ62_RS02595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CUZ62_RS02605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CUZ62_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS02615	COG1363	Peptidase, m42
CUZ62_RS02630	COG0069	glutamate synthase activity
CUZ62_RS02645	COG4619	ABC transporter
CUZ62_RS02650	COG0390	transport system, permease component
CUZ62_RS02655	COG2205	protein histidine kinase activity
CUZ62_RS02660	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS02670	COG2814	Major facilitator Superfamily
CUZ62_RS02675	COG2272	Belongs to the type-B carboxylesterase lipase family
CUZ62_RS02680	COG0531	amino acid
CUZ62_RS02685	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CUZ62_RS02690	COG1063	alcohol dehydrogenase
CUZ62_RS02710	COG1174	glycine betaine transport
CUZ62_RS02715	COG1346	cytolysis
CUZ62_RS02720	COG1380	Effector of murein hydrolase LrgA
CUZ62_RS02725	COG3279	Response regulator of the LytR AlgR family
CUZ62_RS02730	COG3275	phosphorelay sensor kinase activity
CUZ62_RS02740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CUZ62_RS02745	COG3477	response to acidic pH
CUZ62_RS02755	COG0706	membrane insertase activity
CUZ62_RS02765	COG0531	amino acid
CUZ62_RS02770	COG0025	NhaP-type Na H and K H
CUZ62_RS02775	COG1113	amino acid transport
CUZ62_RS02795	COG2226	methyltransferase
CUZ62_RS02800	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CUZ62_RS02805	COG2814	Major facilitator Superfamily
CUZ62_RS02815	COG1929	Belongs to the glycerate kinase type-1 family
CUZ62_RS02830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CUZ62_RS02835	COG0741	lytic transglycosylase activity
CUZ62_RS02840	COG0588	phosphoglycerate mutase activity
CUZ62_RS02850	COG2814	Major facilitator Superfamily
CUZ62_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CUZ62_RS02860	COG0765	amino acid transport
CUZ62_RS02865	COG1126	abc transporter atp-binding protein
CUZ62_RS02885	COG3443	Belongs to the bacterial solute-binding protein 9 family
CUZ62_RS02885	COG0803	Belongs to the bacterial solute-binding protein 9 family
CUZ62_RS02890	COG2353	YceI-like domain
CUZ62_RS02915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CUZ62_RS02920	COG2146	nitrite reductase [NAD(P)H] activity
CUZ62_RS02930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CUZ62_RS02935	COG1140	nitrate reductase beta subunit
CUZ62_RS02940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CUZ62_RS02945	COG2181	nitrate reductase activity
CUZ62_RS02955	COG4585	Histidine kinase
CUZ62_RS02960	COG2197	response regulator
CUZ62_RS02965	COG2223	nitrite transmembrane transporter activity
CUZ62_RS02975	COG1846	Transcriptional regulator
CUZ62_RS03000	COG3871	stress protein (general stress protein 26)
CUZ62_RS03015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS03015	COG1263	PTS System
CUZ62_RS03030	COG1511	domain protein
CUZ62_RS03060	COG0492	ferredoxin-NADP+ reductase activity
CUZ62_RS03070	COG0604	alcohol dehydrogenase
CUZ62_RS03075	COG2822	iron ion transport
CUZ62_RS03080	COG2837	iron assimilation
CUZ62_RS03085	COG0672	)-iron permease
CUZ62_RS03090	COG0805	protein transport
CUZ62_RS03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CUZ62_RS03105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CUZ62_RS03105	COG0463	Glycosyl transferase, family 2
CUZ62_RS03110	COG1620	l-lactate permease
CUZ62_RS03115	COG0438	transferase activity, transferring glycosyl groups
CUZ62_RS03120	COG0579	oxidoreductase
CUZ62_RS03135	COG5002	protein histidine kinase activity
CUZ62_RS03135	COG3850	Histidine kinase
CUZ62_RS03140	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS03145	COG0577	efflux transmembrane transporter activity
CUZ62_RS03150	COG1136	(ABC) transporter
CUZ62_RS03165	COG4640	response to antibiotic
CUZ62_RS03170	COG2814	Major facilitator Superfamily
CUZ62_RS03180	COG1566	PFAM secretion protein HlyD family protein
CUZ62_RS03185	COG2814	Major facilitator Superfamily
CUZ62_RS03210	COG0598	Magnesium transport protein CorA
CUZ62_RS03215	COG1304	FMN binding
CUZ62_RS03220	COG0786	glutamate:sodium symporter activity
CUZ62_RS03225	COG2094	Belongs to the DNA glycosylase MPG family
CUZ62_RS03240	COG1742	UPF0060 membrane protein
CUZ62_RS03250	COG2258	MOSC domain
CUZ62_RS03255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CUZ62_RS03265	COG1266	CAAX protease self-immunity
CUZ62_RS03270	COG0010	Belongs to the arginase family
CUZ62_RS03280	COG1473	amidohydrolase
CUZ62_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS03290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CUZ62_RS03305	COG1737	Transcriptional regulator
CUZ62_RS03310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS03310	COG1263	PTS System
CUZ62_RS03320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CUZ62_RS03340	COG1113	amino acid transport
CUZ62_RS03355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS03355	COG1263	PTS System
CUZ62_RS03360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CUZ62_RS03375	COG2378	regulation of single-species biofilm formation
CUZ62_RS03385	COG1316	TRANSCRIPTIONal
CUZ62_RS03390	COG3383	formate dehydrogenase (NAD+) activity
CUZ62_RS03395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CUZ62_RS03415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CUZ62_RS03420	COG2076	Multidrug Resistance protein
CUZ62_RS03425	COG2076	Multidrug Resistance protein
CUZ62_RS03430	COG3942	CHAP domain
CUZ62_RS03445	COG1757	Na H antiporter
CUZ62_RS03455	COG3942	CHAP domain
CUZ62_RS03490	COG1960	acyl-CoA dehydrogenase activity
CUZ62_RS03495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CUZ62_RS03500	COG1957	nucleoside hydrolase
CUZ62_RS03505	COG1268	BioY protein
CUZ62_RS03515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CUZ62_RS03520	COG0725	ABC transporter, periplasmic molybdate-binding protein
CUZ62_RS03525	COG4149	molybdate abc transporter
CUZ62_RS03530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CUZ62_RS03535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CUZ62_RS03545	COG0315	cyclic pyranopterin monophosphate synthase activity
CUZ62_RS03570	COG0746	molybdenum cofactor guanylyltransferase activity
CUZ62_RS03575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CUZ62_RS03605	COG2348	transferase activity, transferring amino-acyl groups
CUZ62_RS03610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CUZ62_RS03630	COG4975	Glucose uptake
CUZ62_RS03640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CUZ62_RS03640	COG0551	DNA topoisomerase type I activity
CUZ62_RS03645	COG2252	PERMEase
CUZ62_RS03655	COG0051	transcription antitermination factor activity, RNA binding
CUZ62_RS03660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CUZ62_RS03665	COG0088	Forms part of the polypeptide exit tunnel
CUZ62_RS03670	COG0089	rRNA binding
CUZ62_RS03675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CUZ62_RS03680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CUZ62_RS03685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CUZ62_RS03690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CUZ62_RS03695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CUZ62_RS03700	COG0255	Belongs to the universal ribosomal protein uL29 family
CUZ62_RS03705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CUZ62_RS03710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CUZ62_RS03715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CUZ62_RS03720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CUZ62_RS03730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CUZ62_RS03735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CUZ62_RS03740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CUZ62_RS03745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CUZ62_RS03750	COG1841	ribosomal large subunit assembly
CUZ62_RS03755	COG0200	Binds to the 23S rRNA
CUZ62_RS03760	COG0201	protein transport
CUZ62_RS03765	COG0563	adenylate kinase activity
CUZ62_RS03770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CUZ62_RS03775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CUZ62_RS03780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CUZ62_RS03790	COG0202	RNA polymerase activity
CUZ62_RS03795	COG0203	ribosomal protein L17
CUZ62_RS03800	COG1122	ATPase activity
CUZ62_RS03805	COG1122	ATPase activity
CUZ62_RS03815	COG0101	tRNA pseudouridine synthase activity
CUZ62_RS03820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CUZ62_RS03825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CUZ62_RS03830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CUZ62_RS03835	COG1349	DNA-binding transcription factor activity
CUZ62_RS03845	COG0698	ribose 5-phosphate isomerase
CUZ62_RS03850	COG0698	ribose 5-phosphate isomerase
CUZ62_RS03855	COG1105	Belongs to the carbohydrate kinase PfkB family
CUZ62_RS03860	COG3684	Belongs to the aldolase LacD family
CUZ62_RS03865	COG1447	Phosphotransferase system cellobiose-specific component IIA
CUZ62_RS03870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CUZ62_RS03870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CUZ62_RS03875	COG2723	6-phospho-beta-galactosidase activity
CUZ62_RS03885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CUZ62_RS03890	COG0604	alcohol dehydrogenase
CUZ62_RS03895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CUZ62_RS03910	COG1302	Protein conserved in bacteria
CUZ62_RS03920	COG4264	IucA IucC family
CUZ62_RS03925	COG2814	Major facilitator Superfamily
CUZ62_RS03935	COG3457	Alanine racemase
CUZ62_RS03940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CUZ62_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS03950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS03955	COG3314	Sporulation integral membrane protein YlbJ
CUZ62_RS03960	COG2329	Antibiotic biosynthesis monooxygenase
CUZ62_RS03970	COG1988	membrane-bound metal-dependent
CUZ62_RS03975	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CUZ62_RS03980	COG1272	protein, Hemolysin III
CUZ62_RS03995	COG2814	Major facilitator Superfamily
CUZ62_RS04000	COG0489	protein tyrosine kinase activity
CUZ62_RS04055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CUZ62_RS04065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CUZ62_RS04075	COG1119	ATPase activity
CUZ62_RS04080	COG0561	phosphatase activity
CUZ62_RS04105	COG0640	Transcriptional regulator
CUZ62_RS04110	COG0702	epimerase
CUZ62_RS04115	COG1482	cell wall glycoprotein biosynthetic process
CUZ62_RS04140	COG0783	Belongs to the Dps family
CUZ62_RS04145	COG0813	purine-nucleoside phosphorylase activity
CUZ62_RS04150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CUZ62_RS04155	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CUZ62_RS04160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CUZ62_RS04170	COG1854	S-ribosylhomocysteine lyase activity
CUZ62_RS04190	COG5146	pantothenate kinase activity
CUZ62_RS04205	COG0504	CTP synthase activity
CUZ62_RS04215	COG0191	fructose-bisphosphate aldolase activity
CUZ62_RS04220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUZ62_RS04230	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS04235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CUZ62_RS04240	COG0254	rRNA binding
CUZ62_RS04245	COG1435	thymidine kinase activity
CUZ62_RS04250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CUZ62_RS04255	COG2890	protein-(glutamine-N5) methyltransferase activity
CUZ62_RS04260	COG0009	L-threonylcarbamoyladenylate synthase
CUZ62_RS04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUZ62_RS04270	COG4475	Protein of unknown function (DUF436)
CUZ62_RS04275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CUZ62_RS04280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CUZ62_RS04285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CUZ62_RS04295	COG0356	it plays a direct role in the translocation of protons across the membrane
CUZ62_RS04300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUZ62_RS04305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CUZ62_RS04310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CUZ62_RS04315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CUZ62_RS04320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CUZ62_RS04325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CUZ62_RS04330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CUZ62_RS04340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CUZ62_RS04345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CUZ62_RS04355	COG0629	single-stranded DNA binding
CUZ62_RS04360	COG1388	LysM domain
CUZ62_RS04365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CUZ62_RS04375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CUZ62_RS04380	COG0352	thiamine-phosphate diphosphorylase activity
CUZ62_RS04385	COG0706	membrane insertase activity
CUZ62_RS04395	COG1418	mRNA catabolic process
CUZ62_RS04400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUZ62_RS04405	COG1937	Protein conserved in bacteria
CUZ62_RS04425	COG0772	Belongs to the SEDS family
CUZ62_RS04430	COG1181	Belongs to the D-alanine--D-alanine ligase family
CUZ62_RS04435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CUZ62_RS04440	COG0513	Belongs to the DEAD box helicase family
CUZ62_RS04450	COG3428	Bacterial PH domain
CUZ62_RS04460	COG0736	holo-[acyl-carrier-protein] synthase activity
CUZ62_RS04465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CUZ62_RS04475	COG2337	Toxic component of a toxin-antitoxin (TA) module
CUZ62_RS04480	COG2208	phosphoserine phosphatase activity
CUZ62_RS04495	COG1191	sigma factor activity
CUZ62_RS04500	COG2183	response to ionizing radiation
CUZ62_RS04540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CUZ62_RS04545	COG0066	3-isopropylmalate dehydratase activity
CUZ62_RS04550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CUZ62_RS04555	COG0473	3-isopropylmalate dehydrogenase activity
CUZ62_RS04560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CUZ62_RS04565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CUZ62_RS04570	COG0440	acetolactate synthase activity
CUZ62_RS04575	COG0028	Belongs to the TPP enzyme family
CUZ62_RS04580	COG0129	dihydroxy-acid dehydratase activity
CUZ62_RS04585	COG0802	atpase or kinase
CUZ62_RS04590	COG1214	PFAM Peptidase M22, glycoprotease
CUZ62_RS04595	COG0456	acetyltransferase
CUZ62_RS04600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CUZ62_RS04605	COG0488	(ABC) transporter
CUZ62_RS04610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CUZ62_RS04615	COG2391	methyltransferase activity
CUZ62_RS04620	COG0425	Belongs to the sulfur carrier protein TusA family
CUZ62_RS04625	COG0004	ammonium transporteR
CUZ62_RS04630	COG1609	Transcriptional regulator
CUZ62_RS04635	COG1621	beta-fructofuranosidase activity
CUZ62_RS04640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CUZ62_RS04645	COG3279	Response regulator of the LytR AlgR family
CUZ62_RS04660	COG4512	PFAM Accessory gene regulator B
CUZ62_RS04685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CUZ62_RS04690	COG0459	protein refolding
CUZ62_RS04695	COG0582	viral genome integration into host DNA
CUZ62_RS04755	COG1725	Transcriptional regulator
CUZ62_RS04770	COG1131	(ABC) transporter
CUZ62_RS04810	COG2706	6-phosphogluconolactonase activity
CUZ62_RS04815	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS04820	COG1227	inorganic diphosphatase activity
CUZ62_RS04825	COG1335	isochorismatase
CUZ62_RS04835	COG1605	Chorismate mutase
CUZ62_RS04835	COG0077	Prephenate dehydratase
CUZ62_RS04845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CUZ62_RS04850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CUZ62_RS04855	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CUZ62_RS04865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CUZ62_RS04870	COG4496	protein, YerC YecD
CUZ62_RS04875	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CUZ62_RS04880	COG0210	DNA helicase
CUZ62_RS04885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CUZ62_RS04890	COG4851	CamS sex pheromone cAM373 precursor
CUZ62_RS04895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CUZ62_RS04900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUZ62_RS04905	COG0154	amidase activity
CUZ62_RS04910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CUZ62_RS04915	COG1597	lipid kinase activity
CUZ62_RS04920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CUZ62_RS04930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CUZ62_RS04940	COG1528	Iron-storage protein
CUZ62_RS04955	COG4129	membrane
CUZ62_RS04960	COG0024	Methionine aminopeptidase
CUZ62_RS04965	COG4221	oxidoreductase activity
CUZ62_RS04985	COG4585	Histidine kinase
CUZ62_RS04990	COG2197	response regulator
CUZ62_RS04995	COG1295	ribonuclease BN
CUZ62_RS05005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CUZ62_RS05010	COG4840	Belongs to the UPF0435 family
CUZ62_RS05015	COG2309	aminopeptidase activity
CUZ62_RS05020	COG1607	acyl-coa hydrolase
CUZ62_RS05030	COG0535	radical SAM domain protein
CUZ62_RS05040	COG0693	protein deglycase activity
CUZ62_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUZ62_RS05050	COG2137	regulation of response to DNA damage stimulus
CUZ62_RS05060	COG1134	teichoic acid transport
CUZ62_RS05060	COG1388	LysM domain
CUZ62_RS05070	COG1988	membrane-bound metal-dependent
CUZ62_RS05075	COG1194	a g-specific adenine glycosylase
CUZ62_RS05080	COG3557	Belongs to the UPF0374 family
CUZ62_RS05090	COG4129	membrane
CUZ62_RS05095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CUZ62_RS05100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CUZ62_RS05105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CUZ62_RS05110	COG0735	belongs to the Fur family
CUZ62_RS05270	COG0765	amino acid transport
CUZ62_RS05275	COG1126	abc transporter atp-binding protein
CUZ62_RS05280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CUZ62_RS05290	COG0363	glucosamine-6-phosphate deaminase activity
CUZ62_RS05305	COG0114	fumarate hydratase activity
CUZ62_RS05310	COG0564	pseudouridine synthase activity
CUZ62_RS05315	COG4585	Histidine kinase
CUZ62_RS05315	COG2203	Gaf domain
CUZ62_RS05320	COG2197	response regulator
CUZ62_RS05330	COG4399	Belongs to the UPF0754 family
CUZ62_RS05335	COG3679	Belongs to the UPF0342 family
CUZ62_RS05345	COG4717	serine-type aminopeptidase activity
CUZ62_RS05350	COG3481	metal-dependent phosphohydrolase, HD sub domain
CUZ62_RS05355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CUZ62_RS05370	COG0537	adenosine 5'-monophosphoramidase activity
CUZ62_RS05375	COG1131	(ABC) transporter
CUZ62_RS05380	COG4473	ABC transporter
CUZ62_RS05410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CUZ62_RS05415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CUZ62_RS05420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CUZ62_RS05475	COG0318	PFAM AMP-dependent synthetase and ligase
CUZ62_RS05485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CUZ62_RS05490	COG0494	nUDIX hydrolase
CUZ62_RS05495	COG1506	peptidase
CUZ62_RS05500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CUZ62_RS05505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CUZ62_RS05515	COG0656	L-ascorbic acid biosynthetic process
CUZ62_RS05520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUZ62_RS05525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CUZ62_RS05535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CUZ62_RS05560	COG3266	domain, Protein
CUZ62_RS05560	COG5632	N-Acetylmuramoyl-L-alanine amidase
CUZ62_RS05560	COG4193	domain, Protein
CUZ62_RS05575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUZ62_RS05575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CUZ62_RS05580	COG0307	riboflavin synthase, alpha
CUZ62_RS05585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUZ62_RS05585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CUZ62_RS05590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CUZ62_RS05595	COG0506	proline dehydrogenase activity
CUZ62_RS05600	COG2267	carboxylic ester hydrolase activity
CUZ62_RS05620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CUZ62_RS05625	COG1242	4 iron, 4 sulfur cluster binding
CUZ62_RS05630	COG2814	Major facilitator Superfamily
CUZ62_RS05635	COG0495	leucyl-tRNA aminoacylation
CUZ62_RS05655	COG2081	HI0933 family
CUZ62_RS05660	COG2244	polysaccharide biosynthetic process
CUZ62_RS05665	COG1187	pseudouridine synthase activity
CUZ62_RS05675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CUZ62_RS05685	COG0510	thiamine kinase activity
CUZ62_RS05690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CUZ62_RS05700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUZ62_RS05710	COG1363	Peptidase, m42
CUZ62_RS05720	COG4848	Belongs to the UPF0354 family
CUZ62_RS05725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUZ62_RS05730	COG1674	ftsk spoiiie
CUZ62_RS05735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CUZ62_RS05740	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CUZ62_RS05750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CUZ62_RS05750	COG1605	Chorismate mutase
CUZ62_RS05755	COG1609	Transcriptional regulator
CUZ62_RS05765	COG0454	-acetyltransferase
CUZ62_RS05770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CUZ62_RS05790	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CUZ62_RS05800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CUZ62_RS05810	COG0477	Major facilitator Superfamily
CUZ62_RS05815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUZ62_RS05820	COG0204	Acyl-transferase
CUZ62_RS05825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS05825	COG1263	PTS System
CUZ62_RS05835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CUZ62_RS05845	COG1764	response to oxidative stress
CUZ62_RS05850	COG0584	glycerophosphoryl diester phosphodiesterase
CUZ62_RS05855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CUZ62_RS05865	COG1956	GAF domain-containing protein
CUZ62_RS05875	COG1104	cysteine desulfurase activity
CUZ62_RS05880	COG0301	tRNA thio-modification
CUZ62_RS05885	COG0730	response to heat
CUZ62_RS05890	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CUZ62_RS05895	COG0827	DNA restriction-modification system
CUZ62_RS05900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CUZ62_RS05905	COG0589	response to stress
CUZ62_RS05910	COG0686	Belongs to the AlaDH PNT family
CUZ62_RS05915	COG0006	proline dipeptidase activity
CUZ62_RS05920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CUZ62_RS05930	COG4109	DRTGG domain
CUZ62_RS05935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CUZ62_RS05940	COG0587	DNA-directed DNA polymerase activity
CUZ62_RS05945	COG0281	malic enzyme
CUZ62_RS05950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CUZ62_RS05955	COG0825	malonyl-CoA metabolic process
CUZ62_RS05960	COG0205	6-phosphofructokinase activity
CUZ62_RS05965	COG0469	pyruvate kinase activity
CUZ62_RS05975	COG1113	amino acid transport
CUZ62_RS05980	COG0372	Belongs to the citrate synthase family
CUZ62_RS05985	COG0538	isocitrate dehydrogenase activity
CUZ62_RS05990	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS05995	COG5002	protein histidine kinase activity
CUZ62_RS06000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUZ62_RS06000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUZ62_RS06010	COG0237	dephospho-CoA kinase activity
CUZ62_RS06015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CUZ62_RS06020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CUZ62_RS06030	COG1484	DNA-dependent DNA replication
CUZ62_RS06035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CUZ62_RS06040	COG0833	amino acid
CUZ62_RS06045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CUZ62_RS06050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CUZ62_RS06055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CUZ62_RS06060	COG4112	unkown
CUZ62_RS06070	COG0544	peptidyl-prolyl cis-trans isomerase activity
CUZ62_RS06075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CUZ62_RS06085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CUZ62_RS06090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CUZ62_RS06095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CUZ62_RS06100	COG0181	hydroxymethylbilane synthase activity
CUZ62_RS06115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CUZ62_RS06125	COG2818	Glycosylase
CUZ62_RS06130	COG0525	valine-tRNA ligase activity
CUZ62_RS06135	COG0285	dihydrofolate synthase activity
CUZ62_RS06145	COG2003	Belongs to the UPF0758 family
CUZ62_RS06170	COG1792	Involved in formation and maintenance of cell shape
CUZ62_RS06180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CUZ62_RS06185	COG2868	ribosomal protein
CUZ62_RS06190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CUZ62_RS06195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CUZ62_RS06200	COG4492	Belongs to the UPF0735 family
CUZ62_RS06205	COG0632	four-way junction helicase activity
CUZ62_RS06210	COG2255	four-way junction helicase activity
CUZ62_RS06215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CUZ62_RS06220	COG0343	queuine tRNA-ribosyltransferase activity
CUZ62_RS06225	COG1862	Preprotein translocase
CUZ62_RS06230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUZ62_RS06230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CUZ62_RS06235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CUZ62_RS06235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CUZ62_RS06240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUZ62_RS06245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CUZ62_RS06250	COG1490	D-aminoacyl-tRNA deacylase activity
CUZ62_RS06255	COG0860	N-Acetylmuramoyl-L-alanine amidase
CUZ62_RS06260	COG0124	histidyl-tRNA synthetase
CUZ62_RS06265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CUZ62_RS06275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CUZ62_RS06280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CUZ62_RS06285	COG1959	2 iron, 2 sulfur cluster binding
CUZ62_RS06290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CUZ62_RS06295	COG1104	cysteine desulfurase activity
CUZ62_RS06300	COG0482	sulfurtransferase activity
CUZ62_RS06310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CUZ62_RS06315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CUZ62_RS06320	COG4472	Bacterial protein of unknown function (DUF965)
CUZ62_RS06325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CUZ62_RS06330	COG3906	Belongs to the UPF0473 family
CUZ62_RS06340	COG0826	peptidase U32
CUZ62_RS06345	COG0826	peptidase U32
CUZ62_RS06350	COG0572	uridine kinase
CUZ62_RS06355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CUZ62_RS06360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CUZ62_RS06365	COG1984	allophanate hydrolase subunit 2
CUZ62_RS06370	COG0511	ligase activity, forming carbon-carbon bonds
CUZ62_RS06375	COG0439	Biotin carboxylase
CUZ62_RS06380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CUZ62_RS06385	COG1914	H( )-stimulated, divalent metal cation uptake system
CUZ62_RS06390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CUZ62_RS06395	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CUZ62_RS06400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CUZ62_RS06405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CUZ62_RS06410	COG1534	Rna-binding protein
CUZ62_RS06415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CUZ62_RS06420	COG1713	HD superfamily hydrolase involved in NAD metabolism
CUZ62_RS06425	COG0799	negative regulation of ribosome biogenesis
CUZ62_RS06430	COG2226	methyltransferase
CUZ62_RS06435	COG1555	photosystem II stabilization
CUZ62_RS06435	COG1596	polysaccharide export
CUZ62_RS06440	COG2131	deaminase
CUZ62_RS06445	COG2333	competence protein COMEC
CUZ62_RS06445	COG0658	competence protein
CUZ62_RS06450	COG1466	dna polymerase III delta subunit
CUZ62_RS06460	COG0268	Binds directly to 16S ribosomal RNA
CUZ62_RS06465	COG0481	GTPase activity
CUZ62_RS06470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CUZ62_RS06475	COG1420	regulation of RNA biosynthetic process
CUZ62_RS06480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CUZ62_RS06485	COG0443	Heat shock 70 kDa protein
CUZ62_RS06490	COG0484	heat shock protein binding
CUZ62_RS06495	COG2264	protein methyltransferase activity
CUZ62_RS06500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CUZ62_RS06505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUZ62_RS06515	COG1030	water channel activity
CUZ62_RS06520	COG4864	UPF0365 protein
CUZ62_RS06530	COG1702	phosphate starvation-inducible protein PhoH
CUZ62_RS06535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CUZ62_RS06540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CUZ62_RS06550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CUZ62_RS06555	COG1381	Involved in DNA repair and RecF pathway recombination
CUZ62_RS06560	COG0423	glycine-tRNA ligase activity
CUZ62_RS06565	COG0517	IMP dehydrogenase activity
CUZ62_RS06570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CUZ62_RS06580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CUZ62_RS06585	COG2384	SAM-dependent methyltransferase
CUZ62_RS06590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CUZ62_RS06595	COG0513	Belongs to the DEAD box helicase family
CUZ62_RS06600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CUZ62_RS06605	COG1121	(ABC) transporter
CUZ62_RS06610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CUZ62_RS06625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CUZ62_RS06630	COG0768	penicillin binding
CUZ62_RS06635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUZ62_RS06640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CUZ62_RS06650	COG4483	Protein conserved in bacteria
CUZ62_RS06655	COG1940	carbohydrate kinase activity
CUZ62_RS06660	COG0011	TIGRFAM Protein of
CUZ62_RS06665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CUZ62_RS06670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CUZ62_RS06675	COG1459	type II secretion system
CUZ62_RS06680	COG4537	Required for transformation and DNA binding
CUZ62_RS06705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CUZ62_RS06710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CUZ62_RS06715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUZ62_RS06720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CUZ62_RS06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CUZ62_RS06730	COG0095	Lipoate-protein ligase
CUZ62_RS06745	COG0006	proline dipeptidase activity
CUZ62_RS06750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CUZ62_RS06755	COG0511	ligase activity, forming carbon-carbon bonds
CUZ62_RS06760	COG0439	Biotin carboxylase
CUZ62_RS06765	COG1302	Protein conserved in bacteria
CUZ62_RS06770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUZ62_RS06775	COG1570	exodeoxyribonuclease VII activity
CUZ62_RS06780	COG1722	exodeoxyribonuclease VII activity
CUZ62_RS06790	COG1438	arginine binding
CUZ62_RS06795	COG0497	DNA recombination
CUZ62_RS06800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUZ62_RS06805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CUZ62_RS06810	COG0022	dehydrogenase e1 component
CUZ62_RS06815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUZ62_RS06825	COG4129	membrane
CUZ62_RS06835	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUZ62_RS06845	COG1609	Transcriptional regulator
CUZ62_RS06850	COG0366	Alpha amylase catalytic
CUZ62_RS06860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CUZ62_RS06865	COG1234	tRNA 3'-trailer cleavage
CUZ62_RS06870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CUZ62_RS06875	COG0300	oxidoreductase activity
CUZ62_RS06885	COG0667	Aldo Keto reductase
CUZ62_RS06890	COG0494	nUDIX hydrolase
CUZ62_RS06895	COG0735	belongs to the Fur family
CUZ62_RS06900	COG4974	Belongs to the 'phage' integrase family
CUZ62_RS06910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CUZ62_RS06915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CUZ62_RS06925	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS06940	COG1141	Ferredoxin
CUZ62_RS06950	COG0514	ATP-dependent DNA helicase (RecQ)
CUZ62_RS06955	COG1388	LysM domain
CUZ62_RS06965	COG0492	ferredoxin-NADP+ reductase activity
CUZ62_RS06975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CUZ62_RS06980	COG0539	negative regulation of cytoplasmic translation
CUZ62_RS06985	COG1160	GTP binding
CUZ62_RS06990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CUZ62_RS07010	COG2226	methyltransferase
CUZ62_RS07015	COG0142	geranyltranstransferase activity
CUZ62_RS07020	COG0105	UTP biosynthetic process
CUZ62_RS07025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CUZ62_RS07030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CUZ62_RS07035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CUZ62_RS07045	COG5582	Belongs to the UPF0302 family
CUZ62_RS07050	COG4347	Protein of unknown function (DUF1405)
CUZ62_RS07055	COG2738	Putative neutral zinc metallopeptidase
CUZ62_RS07060	COG1694	Mazg nucleotide pyrophosphohydrolase
CUZ62_RS07065	COG0438	transferase activity, transferring glycosyl groups
CUZ62_RS07070	COG0617	tRNA 3'-terminal CCA addition
CUZ62_RS07080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CUZ62_RS07080	COG1199	ATP-dependent helicase activity
CUZ62_RS07085	COG0017	Asparaginyl-tRNA synthetase
CUZ62_RS07090	COG3935	DnaD domain protein
CUZ62_RS07095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUZ62_RS07105	COG4499	WXG100 protein secretion system (Wss), protein YukC
CUZ62_RS07105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CUZ62_RS07110	COG3331	DNA recombination
CUZ62_RS07120	COG4474	Belongs to the UPF0398 family
CUZ62_RS07125	COG3599	regulation of cell shape
CUZ62_RS07135	COG0116	Belongs to the methyltransferase superfamily
CUZ62_RS07145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CUZ62_RS07150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CUZ62_RS07175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CUZ62_RS07185	COG1413	lyase activity
CUZ62_RS07190	COG1413	lyase activity
CUZ62_RS07200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CUZ62_RS07220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CUZ62_RS07225	COG2190	(PTS) system
CUZ62_RS07230	COG4479	Belongs to the UPF0346 family
CUZ62_RS07235	COG0793	Belongs to the peptidase S41A family
CUZ62_RS07245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUZ62_RS07250	COG0671	phosphoesterase, PA-phosphatase related
CUZ62_RS07255	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS07260	COG5002	protein histidine kinase activity
CUZ62_RS07265	COG0567	Dehydrogenase, E1 component
CUZ62_RS07270	COG0508	dehydrogenase complex catalyzes the overall conversion of
CUZ62_RS07290	COG0714	Associated with various cellular activities
CUZ62_RS07295	COG4548	von Willebrand factor, type A
CUZ62_RS07300	COG1114	Component of the transport system for branched-chain amino acids
CUZ62_RS07305	COG3853	Toxic anion resistance protein (TelA)
CUZ62_RS07315	COG1254	Belongs to the acylphosphatase family
CUZ62_RS07325	COG1278	Cold shock
CUZ62_RS07345	COG1473	amidohydrolase
CUZ62_RS07350	COG2171	N-acyltransferase activity
CUZ62_RS07355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CUZ62_RS07360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CUZ62_RS07365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CUZ62_RS07375	COG0488	(ABC) transporter
CUZ62_RS07380	COG2996	Protein conserved in bacteria
CUZ62_RS07385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CUZ62_RS07390	COG0573	inorganic phosphate transmembrane transporter activity
CUZ62_RS07395	COG0581	inorganic phosphate transmembrane transporter activity
CUZ62_RS07400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CUZ62_RS07405	COG0704	Plays a role in the regulation of phosphate uptake
CUZ62_RS07410	COG1164	Oligoendopeptidase f
CUZ62_RS07420	COG4607	ABC-type enterochelin transport system periplasmic component
CUZ62_RS07425	COG0561	phosphatase activity
CUZ62_RS07430	COG2348	transferase activity, transferring amino-acyl groups
CUZ62_RS07435	COG2348	transferase activity, transferring amino-acyl groups
CUZ62_RS07445	COG0159	tryptophan synthase activity
CUZ62_RS07455	COG0135	phosphoribosylanthranilate isomerase activity
CUZ62_RS07460	COG0134	indole-3-glycerol-phosphate synthase activity
CUZ62_RS07465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUZ62_RS07470	COG0512	Glutamine amidotransferase of anthranilate synthase
CUZ62_RS07475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CUZ62_RS07480	COG1363	Peptidase, m42
CUZ62_RS07485	COG0287	Prephenate dehydrogenase
CUZ62_RS07490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CUZ62_RS07495	COG1942	4-Oxalocrotonate Tautomerase
CUZ62_RS07510	COG0392	lysyltransferase activity
CUZ62_RS07510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CUZ62_RS07515	COG0628	permease
CUZ62_RS07520	COG3711	transcriptional antiterminator
CUZ62_RS07525	COG1115	amino acid carrier protein
CUZ62_RS07530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CUZ62_RS07535	COG0187	DNA topoisomerase II activity
CUZ62_RS07540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CUZ62_RS07545	COG4841	protein insertion into membrane
CUZ62_RS07550	COG0824	Thioesterase
CUZ62_RS07555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CUZ62_RS07560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CUZ62_RS07565	COG1970	mechanosensitive ion channel activity
CUZ62_RS07570	COG0419	ATPase involved in DNA repair
CUZ62_RS07575	COG0420	3'-5' exonuclease activity
CUZ62_RS07580	COG4846	Membrane protein involved in cytochrome C biogenesis
CUZ62_RS07595	COG4224	UPF0291 protein
CUZ62_RS07605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CUZ62_RS07610	COG2340	Cysteine-rich secretory protein family
CUZ62_RS07615	COG0516	GMP reductase activity
CUZ62_RS07620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CUZ62_RS07630	COG0753	catalase activity
CUZ62_RS07635	COG0833	amino acid
CUZ62_RS07650	COG0083	homoserine kinase activity
CUZ62_RS07655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CUZ62_RS07660	COG0460	homoserine dehydrogenase
CUZ62_RS07665	COG0527	aspartate kinase activity
CUZ62_RS07695	COG2197	response regulator
CUZ62_RS07700	COG4585	Histidine kinase
CUZ62_RS07710	COG1131	(ABC) transporter
CUZ62_RS07715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CUZ62_RS07785	COG4824	toxin secretion phage lysis holin
CUZ62_RS07820	COG3953	SLT domain
CUZ62_RS07820	COG5412	phage tail tape measure protein
CUZ62_RS07865	COG0740	serine-type endopeptidase activity
CUZ62_RS07950	COG1484	DNA-dependent DNA replication
CUZ62_RS08040	COG0789	Transcriptional regulator
CUZ62_RS08045	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CUZ62_RS08050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CUZ62_RS08055	COG0386	Belongs to the glutathione peroxidase family
CUZ62_RS08060	COG1923	regulation of RNA biosynthetic process
CUZ62_RS08065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CUZ62_RS08075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CUZ62_RS08080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CUZ62_RS08085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CUZ62_RS08095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CUZ62_RS08100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CUZ62_RS08110	COG4550	Control of competence regulator ComK, YlbF/YmcA
CUZ62_RS08115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CUZ62_RS08125	COG4195	phage-related replication protein
CUZ62_RS08130	COG1013	pyruvate-flavodoxin oxidoreductase activity
CUZ62_RS08135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CUZ62_RS08135	COG0674	pyruvate-flavodoxin oxidoreductase activity
CUZ62_RS08140	COG1692	metallophosphoesterase
CUZ62_RS08150	COG1418	mRNA catabolic process
CUZ62_RS08165	COG0456	acetyltransferase
CUZ62_RS08175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CUZ62_RS08180	COG1058	Belongs to the CinA family
CUZ62_RS08180	COG1546	Belongs to the CinA family
CUZ62_RS08200	COG0300	oxidoreductase activity
CUZ62_RS08205	COG0612	Peptidase, M16
CUZ62_RS08210	COG0612	Peptidase, M16
CUZ62_RS08215	COG2188	Transcriptional regulator
CUZ62_RS08220	COG1674	ftsk spoiiie
CUZ62_RS08225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CUZ62_RS08230	COG1185	polyribonucleotide nucleotidyltransferase activity
CUZ62_RS08235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CUZ62_RS08240	COG0196	riboflavin kinase activity
CUZ62_RS08245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CUZ62_RS08250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CUZ62_RS08255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CUZ62_RS08260	COG1358	cellular component organization or biogenesis
CUZ62_RS08265	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CUZ62_RS08270	COG0195	Participates in both transcription termination and antitermination
CUZ62_RS08275	COG0779	Required for maturation of 30S ribosomal subunits
CUZ62_RS08280	COG2176	DNA-directed DNA polymerase activity
CUZ62_RS08285	COG0442	prolyl-tRNA aminoacylation
CUZ62_RS08295	COG4589	Belongs to the CDS family
CUZ62_RS08300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CUZ62_RS08305	COG0233	cytoplasmic translational termination
CUZ62_RS08310	COG0528	UMP kinase activity
CUZ62_RS08315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CUZ62_RS08320	COG0052	Belongs to the universal ribosomal protein uS2 family
CUZ62_RS08325	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CUZ62_RS08330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CUZ62_RS08335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CUZ62_RS08340	COG4974	Belongs to the 'phage' integrase family
CUZ62_RS08345	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CUZ62_RS08350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CUZ62_RS08355	COG0758	DNA mediated transformation
CUZ62_RS08365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CUZ62_RS08370	COG0045	succinate-CoA ligase (ADP-forming) activity
CUZ62_RS08375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUZ62_RS08385	COG4485	Bacterial membrane protein, YfhO
CUZ62_RS08395	COG0335	large ribosomal subunit rRNA binding
CUZ62_RS08400	COG0336	Belongs to the RNA methyltransferase TrmD family
CUZ62_RS08405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CUZ62_RS08410	COG0228	four-way junction DNA binding
CUZ62_RS08415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CUZ62_RS08420	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CUZ62_RS08425	COG0552	protein localization to endoplasmic reticulum
CUZ62_RS08430	COG1196	nuclear chromosome segregation
CUZ62_RS08435	COG0571	ribonuclease III activity
CUZ62_RS08440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUZ62_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
CUZ62_RS08455	COG0416	fatty acid biosynthetic process
CUZ62_RS08460	COG1349	DNA-binding transcription factor activity
CUZ62_RS08475	COG1461	Dihydroxyacetone kinase
CUZ62_RS08480	COG1302	Protein conserved in bacteria
CUZ62_RS08485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CUZ62_RS08490	COG1564	THIamine pyrophosphokinase
CUZ62_RS08495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CUZ62_RS08500	COG1162	GTPase activity
CUZ62_RS08510	COG0631	protein serine/threonine phosphatase activity
CUZ62_RS08515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CUZ62_RS08520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CUZ62_RS08520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CUZ62_RS08525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CUZ62_RS08540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CUZ62_RS08545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CUZ62_RS08550	COG1758	RNA polymerase activity
CUZ62_RS08555	COG0194	GDP metabolic process
CUZ62_RS08575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CUZ62_RS08580	COG0284	orotidine-5'-phosphate decarboxylase activity
CUZ62_RS08585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CUZ62_RS08590	COG0505	Belongs to the CarA family
CUZ62_RS08600	COG0540	Belongs to the ATCase OTCase family
CUZ62_RS08605	COG2233	PERMEase
CUZ62_RS08610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CUZ62_RS08615	COG0564	pseudouridine synthase activity
CUZ62_RS08620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CUZ62_RS08625	COG1388	LysM domain
CUZ62_RS08625	COG3942	CHAP domain
CUZ62_RS08635	COG0702	epimerase
CUZ62_RS08640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CUZ62_RS08645	COG3599	regulation of cell shape
CUZ62_RS08655	COG0762	integral membrane protein
CUZ62_RS08660	COG1799	cell septum assembly
CUZ62_RS08665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CUZ62_RS08670	COG1496	oxidoreductase activity
CUZ62_RS08675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CUZ62_RS08680	COG0849	cell division
CUZ62_RS08685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CUZ62_RS08690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CUZ62_RS08695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUZ62_RS08700	COG0768	penicillin binding
CUZ62_RS08705	COG4839	cell division protein FtsL
CUZ62_RS08710	COG0275	rRNA processing
CUZ62_RS08715	COG2001	Belongs to the MraZ family
CUZ62_RS08720	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CUZ62_RS08725	COG0454	-acetyltransferase
CUZ62_RS08730	COG1011	Hydrolase
CUZ62_RS08770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CUZ62_RS08775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CUZ62_RS08780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CUZ62_RS08785	COG1053	succinate dehydrogenase
CUZ62_RS08790	COG2009	succinate dehydrogenase
CUZ62_RS08795	COG0322	excinuclease ABC activity
CUZ62_RS08800	COG3118	belongs to the thioredoxin family
CUZ62_RS08805	COG1193	negative regulation of DNA recombination
CUZ62_RS08810	COG1796	DNA polymerase
CUZ62_RS08810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CUZ62_RS08820	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CUZ62_RS08825	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CUZ62_RS08830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUZ62_RS08830	COG0072	phenylalanine-tRNA ligase activity
CUZ62_RS08835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CUZ62_RS08840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUZ62_RS08845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CUZ62_RS08860	COG1323	Belongs to the UPF0348 family
CUZ62_RS08865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CUZ62_RS08870	COG0742	ribosomal rna small subunit methyltransferase
CUZ62_RS08880	COG4471	UPF0298 protein
CUZ62_RS08890	COG3679	Belongs to the UPF0342 family
CUZ62_RS08895	COG2340	Cysteine-rich secretory protein family
CUZ62_RS08905	COG0109	protoheme IX farnesyltransferase activity
CUZ62_RS08910	COG1612	heme a metabolic process
CUZ62_RS08920	COG0772	Belongs to the SEDS family
CUZ62_RS08925	COG4838	Belongs to the UPF0358 family
CUZ62_RS08930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CUZ62_RS08935	COG4896	Protein conserved in bacteria
CUZ62_RS08940	COG1217	gtp-binding protein TYPA
CUZ62_RS08950	COG0483	inositol monophosphate 1-phosphatase activity
CUZ62_RS08955	COG4493	Belongs to the UPF0637 family
CUZ62_RS08960	COG1914	H( )-stimulated, divalent metal cation uptake system
CUZ62_RS08980	COG1177	transmembrane transport
CUZ62_RS08985	COG1176	ABC-type spermidine putrescine transport system, permease component I
CUZ62_RS08990	COG3842	ATPase activity
CUZ62_RS08995	COG3800	Transcriptional regulator
CUZ62_RS08995	COG1396	sequence-specific DNA binding
CUZ62_RS09000	COG4476	Belongs to the UPF0223 family
CUZ62_RS09030	COG0242	peptide deformylase activity
CUZ62_RS09035	COG5503	Protein of unknown function (DUF1447)
CUZ62_RS09040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CUZ62_RS09050	COG2832	Protein of unknown function (DUF454)
CUZ62_RS09055	COG0569	domain protein
CUZ62_RS09060	COG1294	oxidase, subunit
CUZ62_RS09065	COG1271	oxidase subunit
CUZ62_RS09085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CUZ62_RS09100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CUZ62_RS09120	COG4172	Belongs to the ABC transporter superfamily
CUZ62_RS09125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CUZ62_RS09130	COG0151	Belongs to the GarS family
CUZ62_RS09135	COG0138	bifunctional purine biosynthesis protein purh
CUZ62_RS09145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CUZ62_RS09155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUZ62_RS09160	COG0047	phosphoribosylformylglycinamidine synthase activity
CUZ62_RS09165	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CUZ62_RS09170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CUZ62_RS09175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CUZ62_RS09180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CUZ62_RS09185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CUZ62_RS09210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CUZ62_RS09215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CUZ62_RS09220	COG1845	cytochrome c oxidase, subunit III
CUZ62_RS09225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CUZ62_RS09235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CUZ62_RS09240	COG1316	TRANSCRIPTIONal
CUZ62_RS09270	COG3594	Acyltransferase
CUZ62_RS09275	COG0436	Aminotransferase
CUZ62_RS09280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CUZ62_RS09285	COG0596	Alpha beta hydrolase
CUZ62_RS09290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CUZ62_RS09295	COG1169	isochorismate synthase
CUZ62_RS09300	COG1575	Belongs to the MenA family. Type 1 subfamily
CUZ62_RS09355	COG4873	Protein conserved in bacteria
CUZ62_RS09375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUZ62_RS09380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CUZ62_RS09385	COG0861	Integral membrane protein TerC family
CUZ62_RS09390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CUZ62_RS09400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CUZ62_RS09405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CUZ62_RS09410	COG2814	Major facilitator Superfamily
CUZ62_RS09420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CUZ62_RS09425	COG2382	esterase
CUZ62_RS09430	COG0628	permease
CUZ62_RS09440	COG0569	domain protein
CUZ62_RS09440	COG0475	glutathione-regulated potassium exporter activity
CUZ62_RS09445	COG2239	Acts as a magnesium transporter
CUZ62_RS09450	COG0564	pseudouridine synthase activity
CUZ62_RS09455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CUZ62_RS09460	COG2357	RelA SpoT domain protein
CUZ62_RS09470	COG4116	CYTH
CUZ62_RS09475	COG2346	COG2346, Truncated hemoglobins
CUZ62_RS09480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CUZ62_RS09485	COG1164	Oligoendopeptidase f
CUZ62_RS09495	COG4862	establishment of competence for transformation
CUZ62_RS09500	COG1393	Belongs to the ArsC family
CUZ62_RS09505	COG0180	Tryptophanyl-tRNA synthetase
CUZ62_RS09515	COG4166	transmembrane transport
CUZ62_RS09520	COG4608	Belongs to the ABC transporter superfamily
CUZ62_RS09525	COG0444	Belongs to the ABC transporter superfamily
CUZ62_RS09530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CUZ62_RS09535	COG0601	transmembrane transport
CUZ62_RS09550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CUZ62_RS09560	COG0542	response to heat
CUZ62_RS09575	COG0561	phosphatase activity
CUZ62_RS09580	COG0446	pyridine nucleotide-disulphide oxidoreductase
CUZ62_RS09595	COG0179	Fumarylacetoacetate (FAA) hydrolase
CUZ62_RS09600	COG1074	ATP-dependent DNA helicase activity
CUZ62_RS09605	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CUZ62_RS09620	COG0398	Pfam SNARE associated Golgi protein
CUZ62_RS09625	COG0166	Belongs to the GPI family
CUZ62_RS09630	COG0137	argininosuccinate synthase activity
CUZ62_RS09635	COG0165	Argininosuccinate lyase
CUZ62_RS09640	COG0584	glycerophosphoryl diester phosphodiesterase
CUZ62_RS09655	COG1902	pentaerythritol trinitrate reductase activity
CUZ62_RS09660	COG1098	S1 RNA binding domain
CUZ62_RS09665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CUZ62_RS09675	COG2111	Na H antiporter
CUZ62_RS09675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CUZ62_RS09680	COG2111	Na H antiporter
CUZ62_RS09685	COG1006	Multisubunit Na H antiporter MnhC subunit
CUZ62_RS09690	COG0651	ATP synthesis coupled electron transport
CUZ62_RS09695	COG1863	multisubunit Na H antiporter MnhE subunit
CUZ62_RS09700	COG2212	antiporter activity
CUZ62_RS09705	COG1320	monovalent cation:proton antiporter activity
CUZ62_RS09715	COG2050	protein possibly involved in aromatic compounds catabolism
CUZ62_RS09720	COG2056	Na+-H+ antiporter family
CUZ62_RS09725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CUZ62_RS09730	COG1252	NADH dehydrogenase
CUZ62_RS09735	COG0316	Belongs to the HesB IscA family
CUZ62_RS09740	COG4844	belongs to the
CUZ62_RS09745	COG1252	NADH dehydrogenase
CUZ62_RS09750	COG4837	Protein of unknown function (DUF1462)
CUZ62_RS09755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CUZ62_RS09765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CUZ62_RS09770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CUZ62_RS09775	COG1696	Membrane protein involved in D-alanine export
CUZ62_RS09780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CUZ62_RS09795	COG0647	UMP catabolic process
CUZ62_RS09800	COG2445	Protein of unknown function DUF86
CUZ62_RS09810	COG4470	Protein conserved in bacteria
CUZ62_RS09815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CUZ62_RS09820	COG0737	Belongs to the 5'-nucleotidase family
CUZ62_RS09825	COG0730	response to heat
CUZ62_RS09830	COG1801	Protein of unknown function DUF72
CUZ62_RS09835	COG2070	2-Nitropropane dioxygenase
CUZ62_RS09845	COG0719	Fe-S assembly protein
CUZ62_RS09850	COG0822	iron-sulfur transferase activity
CUZ62_RS09860	COG0719	Fe-S assembly protein
CUZ62_RS09865	COG0396	ATPase activity
CUZ62_RS09880	COG3237	CsbD-like
CUZ62_RS09885	COG1464	Belongs to the NlpA lipoprotein family
CUZ62_RS09890	COG2011	ABC-type metal ion transport system permease component
CUZ62_RS09895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CUZ62_RS09905	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CUZ62_RS09910	COG0509	glycine decarboxylation via glycine cleavage system
CUZ62_RS09915	COG1393	Belongs to the ArsC family
CUZ62_RS09920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CUZ62_RS09930	COG0710	3-dehydroquinate dehydratase activity
CUZ62_RS09935	COG1764	response to oxidative stress
CUZ62_RS09945	COG1279	arginine transmembrane transporter activity
CUZ62_RS09950	COG0406	alpha-ribazole phosphatase activity
CUZ62_RS09990	COG0456	acetyltransferase
CUZ62_RS09995	COG4195	phage-related replication protein
CUZ62_RS10025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CUZ62_RS10030	COG0557	exoribonuclease II activity
CUZ62_RS10035	COG1647	Serine aminopeptidase, S33
CUZ62_RS10040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CUZ62_RS10050	COG0148	phosphopyruvate hydratase activity
CUZ62_RS10055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CUZ62_RS10060	COG0149	triose-phosphate isomerase activity
CUZ62_RS10065	COG0126	phosphoglycerate kinase activity
CUZ62_RS10075	COG2390	Transcriptional regulator
CUZ62_RS10095	COG1090	epimerase
CUZ62_RS10105	COG0740	serine-type endopeptidase activity
CUZ62_RS10115	COG1481	regulation of sporulation
CUZ62_RS10120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CUZ62_RS10125	COG1660	Displays ATPase and GTPase activities
CUZ62_RS10130	COG0492	ferredoxin-NADP+ reductase activity
CUZ62_RS10145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CUZ62_RS10150	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CUZ62_RS10155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CUZ62_RS10160	COG0556	nucleotide-excision repair
CUZ62_RS10175	COG0300	oxidoreductase activity
CUZ62_RS10180	COG1388	LysM domain
CUZ62_RS10180	COG3942	CHAP domain
CUZ62_RS10190	COG0653	protein targeting
CUZ62_RS10195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CUZ62_RS10200	COG1040	competence protein
CUZ62_RS10205	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CUZ62_RS10215	COG1739	Uncharacterized protein family UPF0029
CUZ62_RS10220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CUZ62_RS10225	COG2199	diguanylate cyclase activity
CUZ62_RS10240	COG2195	Cleaves the N-terminal amino acid of tripeptides
CUZ62_RS10245	COG1929	Belongs to the glycerate kinase type-1 family
CUZ62_RS10265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CUZ62_RS10280	COG4607	ABC-type enterochelin transport system periplasmic component
CUZ62_RS10285	COG4604	ABC transporter, ATP-binding protein
CUZ62_RS10290	COG4605	iron ion homeostasis
CUZ62_RS10295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS10300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUZ62_RS10305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CUZ62_RS10310	COG1780	Probably involved in ribonucleotide reductase function
CUZ62_RS10320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CUZ62_RS10325	COG3104	oligopeptide transport
CUZ62_RS10330	COG1597	lipid kinase activity
CUZ62_RS10340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CUZ62_RS10345	COG3104	oligopeptide transport
CUZ62_RS10350	COG1174	glycine betaine transport
CUZ62_RS10360	COG0514	ATP-dependent DNA helicase (RecQ)
CUZ62_RS10365	COG0488	(ABC) transporter
CUZ62_RS10375	COG1368	sulfuric ester hydrolase activity
CUZ62_RS10380	COG1984	allophanate hydrolase subunit 2
CUZ62_RS10385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CUZ62_RS10405	COG0512	Glutamine amidotransferase of anthranilate synthase
CUZ62_RS10405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CUZ62_RS10410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CUZ62_RS10415	COG0720	synthase
CUZ62_RS10420	COG0602	queuosine metabolic process
CUZ62_RS10430	COG0463	Glycosyl transferase, family 2
CUZ62_RS10440	COG0656	L-ascorbic acid biosynthetic process
CUZ62_RS10445	COG1253	flavin adenine dinucleotide binding
CUZ62_RS10450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CUZ62_RS10450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CUZ62_RS10450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CUZ62_RS10455	COG1105	Belongs to the carbohydrate kinase PfkB family
CUZ62_RS10460	COG1349	DNA-binding transcription factor activity
CUZ62_RS10465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CUZ62_RS10505	COG0471	metal ion transport
CUZ62_RS10515	COG0523	cobalamin synthesis protein
CUZ62_RS10525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CUZ62_RS10530	COG4988	ABC transporter
CUZ62_RS10535	COG1968	undecaprenyl-diphosphatase activity
CUZ62_RS10545	COG1671	Belongs to the UPF0178 family
CUZ62_RS10550	COG1611	Belongs to the LOG family
CUZ62_RS10555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUZ62_RS10570	COG0456	acetyltransferase
CUZ62_RS10580	COG2839	Protein conserved in bacteria
CUZ62_RS10590	COG0583	DNA-binding transcription factor activity
CUZ62_RS10600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CUZ62_RS10615	COG0217	transcriptional regulatory protein
CUZ62_RS10635	COG1388	LysM domain
CUZ62_RS10635	COG3942	CHAP domain
CUZ62_RS10640	COG0306	phosphate transporter
CUZ62_RS10645	COG1392	Phosphate transport regulator
CUZ62_RS10650	COG0577	efflux transmembrane transporter activity
CUZ62_RS10655	COG1136	(ABC) transporter
CUZ62_RS10660	COG2205	protein histidine kinase activity
CUZ62_RS10665	COG0745	RESPONSE REGULATOR receiver
CUZ62_RS10670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUZ62_RS10680	COG0657	acetylesterase activity
CUZ62_RS10685	COG3949	Membrane
CUZ62_RS10695	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CUZ62_RS10705	COG2376	Dihydroxyacetone kinase
CUZ62_RS10710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS10715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS10720	COG1120	ATPase activity
CUZ62_RS10725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CUZ62_RS10730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUZ62_RS10735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CUZ62_RS10735	COG0463	Glycosyl transferase, family 2
CUZ62_RS10745	COG1132	(ABC) transporter
CUZ62_RS10755	COG1686	Belongs to the peptidase S11 family
CUZ62_RS10760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CUZ62_RS10770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CUZ62_RS10775	COG1682	transport, permease protein
CUZ62_RS10780	COG1134	teichoic acid transport
CUZ62_RS10785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CUZ62_RS10800	COG1321	iron dependent repressor
CUZ62_RS10825	COG1320	monovalent cation:proton antiporter activity
CUZ62_RS10830	COG2212	antiporter activity
CUZ62_RS10835	COG1863	multisubunit Na H antiporter MnhE subunit
CUZ62_RS10840	COG0651	ATP synthesis coupled electron transport
CUZ62_RS10845	COG1006	Multisubunit Na H antiporter MnhC subunit
CUZ62_RS10850	COG2111	Na H antiporter
CUZ62_RS10855	COG2111	Na H antiporter
CUZ62_RS10855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CUZ62_RS10920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CUZ62_RS10925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CUZ62_RS10940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CUZ62_RS10945	COG0018	arginyl-trna synthetase
CUZ62_RS10995	COG0456	acetyltransferase
CUZ62_RS11015	COG1131	(ABC) transporter
CUZ62_RS11025	COG3173	Aminoglycoside phosphotransferase
CUZ62_RS11095	COG1078	dGTPase activity
CUZ62_RS11105	COG0655	NAD(P)H dehydrogenase (quinone) activity
CUZ62_RS11110	COG0667	Aldo Keto reductase
CUZ62_RS11120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CUZ62_RS11125	COG1278	Cold shock
CUZ62_RS11130	COG4844	belongs to the
CUZ62_RS11155	COG0095	Lipoate-protein ligase
CUZ62_RS11165	COG3253	May function as heme-dependent peroxidase
CUZ62_RS11170	COG2966	Psort location CytoplasmicMembrane, score
CUZ62_RS11185	COG2363	Small membrane protein
CUZ62_RS11195	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CUZ62_RS11225	COG0183	Belongs to the thiolase family
CUZ62_RS11230	COG0318	PFAM AMP-dependent synthetase and ligase
CUZ62_RS11285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CUZ62_RS11290	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CUZ62_RS11300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CUZ62_RS11305	COG1469	GTP cyclohydrolase I activity
CUZ62_RS11340	COG0431	NADPH-dependent FMN reductase
CUZ62_RS11345	COG0561	phosphatase activity
CUZ62_RS11355	COG1428	Deoxynucleoside kinase
CUZ62_RS11360	COG1428	Deoxynucleoside kinase
CUZ62_RS11365	COG0546	phosphoglycolate phosphatase activity
CUZ62_RS11405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CUZ62_RS11410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CUZ62_RS11415	COG0737	Belongs to the 5'-nucleotidase family
CUZ62_RS11440	COG1473	amidohydrolase
CUZ62_RS11445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CUZ62_RS11450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CUZ62_RS11460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CUZ62_RS11470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CUZ62_RS11475	COG0085	RNA polymerase activity
CUZ62_RS11480	COG2813	Specifically methylates the guanine in position
CUZ62_RS11485	COG0222	ribosome binding
CUZ62_RS11490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CUZ62_RS11500	COG0081	regulation of translation
CUZ62_RS11505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CUZ62_RS11510	COG0250	Participates in transcription elongation, termination and antitermination
CUZ62_RS11515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CUZ62_RS11520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CUZ62_RS11530	COG3688	RNA-binding protein containing a PIN domain
CUZ62_RS11535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CUZ62_RS11540	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CUZ62_RS11545	COG0215	cysteine-tRNA ligase activity
CUZ62_RS11550	COG1045	serine acetyltransferase
CUZ62_RS11555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CUZ62_RS11560	COG4956	integral membrane protein (PIN domain superfamily)
CUZ62_RS11565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CUZ62_RS11570	COG0542	response to heat
CUZ62_RS11575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CUZ62_RS11580	COG3880	PFAM UvrB UvrC protein
CUZ62_RS11585	COG4463	regulation of RNA biosynthetic process
CUZ62_RS11590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CUZ62_RS11595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CUZ62_RS11600	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CUZ62_RS11605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CUZ62_RS11610	COG2259	Doxx family
CUZ62_RS11695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CUZ62_RS11700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CUZ62_RS11715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CUZ62_RS11720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CUZ62_RS11725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CUZ62_RS11735	COG0037	tRNA processing
CUZ62_RS11740	COG1098	S1 RNA binding domain
CUZ62_RS11750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CUZ62_RS11755	COG3956	TIGRFAM MazG family protein
CUZ62_RS11760	COG2244	polysaccharide biosynthetic process
CUZ62_RS11765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CUZ62_RS11770	COG0193	aminoacyl-tRNA hydrolase activity
CUZ62_RS11775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CUZ62_RS11780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CUZ62_RS11785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CUZ62_RS11790	COG2088	sporulation resulting in formation of a cellular spore
CUZ62_RS11795	COG0251	oxidation-reduction process
CUZ62_RS11800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUZ62_RS11805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CUZ62_RS11810	COG4466	Protein conserved in bacteria
CUZ62_RS11815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CUZ62_RS11820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CUZ62_RS11825	COG0084	hydrolase, TatD family'
CUZ62_RS11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUZ62_RS11830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CUZ62_RS11835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CUZ62_RS11840	COG2827	Endonuclease containing a URI domain
CUZ62_RS11845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CUZ62_RS11850	COG4467	Involved in initiation control of chromosome replication
CUZ62_RS11855	COG1774	PSP1 C-terminal conserved region
CUZ62_RS11860	COG0470	DNA polymerase III
CUZ62_RS11865	COG3870	Protein conserved in bacteria
CUZ62_RS11870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CUZ62_RS11875	COG1982	Orn Lys Arg decarboxylase major
CUZ62_RS11900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CUZ62_RS11910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CUZ62_RS11925	COG2188	Transcriptional regulator
CUZ62_RS11930	COG0366	Alpha amylase catalytic
CUZ62_RS11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CUZ62_RS11935	COG1263	PTS System
CUZ62_RS11945	COG0493	'glutamate synthase
CUZ62_RS11950	COG0067	glutamate synthase
CUZ62_RS11950	COG0070	glutamate synthase
CUZ62_RS11950	COG0069	glutamate synthase activity
CUZ62_RS11985	COG3942	CHAP domain
CUZ62_RS11985	COG1388	LysM domain
CUZ62_RS11990	COG0626	cystathionine gamma-synthase activity
CUZ62_RS11995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CUZ62_RS12010	COG0733	neurotransmitter:sodium symporter activity
CUZ62_RS12025	COG1647	Serine aminopeptidase, S33
CUZ62_RS12035	COG0671	phosphoesterase, PA-phosphatase related
CUZ62_RS12045	COG5609	conserved protein (DUF2294)
CUZ62_RS12050	COG3002	Belongs to the UPF0753 family
CUZ62_RS12055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CUZ62_RS12065	COG3759	membrane
CUZ62_RS12080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CUZ62_RS12090	COG3728	DNA packaging
CUZ62_RS12090	COG5484	DNA packaging
CUZ62_RS12150	COG0456	acetyltransferase
CUZ62_RS12205	COG3682	Transcriptional regulator
CUZ62_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
CUZ62_RS12225	COG1902	pentaerythritol trinitrate reductase activity
CUZ62_RS12280	COG1280	lysine exporter protein (LysE YggA)
CUZ62_RS12285	COG0406	alpha-ribazole phosphatase activity
CUZ62_RS12295	COG3634	alkyl hydroperoxide reductase activity
CUZ62_RS12300	COG0450	alkyl hydroperoxide reductase
CUZ62_RS12310	COG0778	Nitroreductase
CUZ62_RS12315	COG1823	symporter activity
CUZ62_RS12335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CUZ62_RS12340	COG2233	PERMEase
CUZ62_RS12345	COG0517	IMP dehydrogenase activity
CUZ62_RS12345	COG0516	GMP reductase activity
CUZ62_RS12350	COG0519	Catalyzes the synthesis of GMP from XMP
CUZ62_RS12350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CUZ62_RS12355	COG0582	viral genome integration into host DNA
CUZ62_RS12425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CUZ62_RS12435	COG0360	Binds together with S18 to 16S ribosomal RNA
CUZ62_RS12450	COG0012	GTP binding
CUZ62_RS12455	COG4481	Protein conserved in bacteria
CUZ62_RS12460	COG0668	transmembrane transport
CUZ62_RS12465	COG1475	DNA binding
CUZ62_RS12470	COG0626	cystathionine gamma-synthase activity
CUZ62_RS12475	COG0626	cystathionine gamma-synthase activity
CUZ62_RS12480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CUZ62_RS12480	COG0646	methionine synthase
CUZ62_RS12485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CUZ62_RS12500	COG0488	(ABC) transporter
CUZ62_RS12510	COG0346	lactoylglutathione lyase activity
CUZ62_RS12515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CUZ62_RS12540	COG1136	(ABC) transporter
CUZ62_RS12545	COG0577	efflux transmembrane transporter activity
CUZ62_RS12585	COG0357	Ribosomal RNA small subunit methyltransferase G
CUZ62_RS12590	COG0445	tRNA wobble uridine modification
CUZ62_RS12595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CUZ62_RS12600	COG0594	ribonuclease P activity
CUZ62_RS12660	COG3226	Transcriptional regulator
CUZ62_RS12695	COG3093	addiction module antidote protein HigA