locus-tag	class	description
MKD39_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MKD39_RS00010	COG0592	DNA-directed DNA polymerase activity
MKD39_RS00015	COG2501	S4 domain
MKD39_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKD39_RS00025	COG0187	DNA topoisomerase II activity
MKD39_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKD39_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKD39_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MKD39_RS00045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MKD39_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKD39_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MKD39_RS00070	COG0359	binds to the 23S rRNA
MKD39_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
MKD39_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKD39_RS00095	COG0745	RESPONSE REGULATOR receiver
MKD39_RS00100	COG5002	protein histidine kinase activity
MKD39_RS00105	COG4863	YycH protein
MKD39_RS00115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MKD39_RS00120	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MKD39_RS00130	COG0640	Transcriptional regulator
MKD39_RS00135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKD39_RS00160	COG2030	dehydratase
MKD39_RS00165	COG0584	glycerophosphoryl diester phosphodiesterase
MKD39_RS00170	COG3425	synthase
MKD39_RS00180	COG2217	Heavy metal translocating P-type atpase
MKD39_RS00185	COG1388	LysM domain
MKD39_RS00210	COG0789	Transcriptional regulator
MKD39_RS00220	COG0702	epimerase
MKD39_RS00225	COG2130	NADP-dependent
MKD39_RS00240	COG0640	Transcriptional regulator
MKD39_RS00245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKD39_RS00250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKD39_RS00270	COG0668	transmembrane transport
MKD39_RS00290	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKD39_RS00320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MKD39_RS00340	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MKD39_RS00350	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKD39_RS00355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKD39_RS00360	COG1121	(ABC) transporter
MKD39_RS00365	COG0523	cobalamin synthesis protein
MKD39_RS00370	COG1114	Component of the transport system for branched-chain amino acids
MKD39_RS00380	COG0747	negative chemotaxis
MKD39_RS00390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKD39_RS00395	COG4172	Belongs to the ABC transporter superfamily
MKD39_RS00425	COG0789	Transcriptional regulator
MKD39_RS00435	COG1253	flavin adenine dinucleotide binding
MKD39_RS00440	COG1959	2 iron, 2 sulfur cluster binding
MKD39_RS00445	COG2910	NAD(P)H-binding
MKD39_RS00450	COG0583	DNA-binding transcription factor activity
MKD39_RS00455	COG0583	DNA-binding transcription factor activity
MKD39_RS00470	COG1113	amino acid transport
MKD39_RS00520	COG1609	Transcriptional regulator
MKD39_RS00525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKD39_RS00530	COG1869	D-ribose catabolic process
MKD39_RS00535	COG1129	ABC transporter
MKD39_RS00540	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKD39_RS00545	COG1879	ABC-type sugar transport system periplasmic component
MKD39_RS00555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MKD39_RS00560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MKD39_RS00565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MKD39_RS00575	COG1876	peptidase activity
MKD39_RS00580	COG1737	Transcriptional regulator
MKD39_RS00585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKD39_RS00590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKD39_RS00595	COG1447	Phosphotransferase system cellobiose-specific component IIA
MKD39_RS00610	COG2971	BadF BadG BcrA BcrD
MKD39_RS00620	COG3152	Membrane
MKD39_RS00630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKD39_RS00640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKD39_RS00645	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKD39_RS00650	COG1288	antiporter activity
MKD39_RS00665	COG2318	DinB family
MKD39_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS00710	COG1063	alcohol dehydrogenase
MKD39_RS00715	COG1846	Transcriptional regulator
MKD39_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKD39_RS00735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MKD39_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKD39_RS00750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MKD39_RS00755	COG0022	dehydrogenase e1 component
MKD39_RS00760	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKD39_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKD39_RS00770	COG1695	Transcriptional regulator
MKD39_RS00785	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MKD39_RS00790	COG2962	Rard protein
MKD39_RS00800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKD39_RS00855	COG0789	Transcriptional regulator
MKD39_RS00880	COG2314	TM2 domain
MKD39_RS00895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MKD39_RS00900	COG0549	Belongs to the carbamate kinase family
MKD39_RS00910	COG3093	addiction module antidote protein HigA
MKD39_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKD39_RS00950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MKD39_RS00965	COG0471	metal ion transport
MKD39_RS00970	COG5505	Protein of unknown function (DUF819)
MKD39_RS00975	COG4336	lyase activity
MKD39_RS00985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MKD39_RS00995	COG0363	glucosamine-6-phosphate deaminase activity
MKD39_RS01000	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MKD39_RS01015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKD39_RS01020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKD39_RS01045	COG1124	(ABC) transporter
MKD39_RS01050	COG0444	Belongs to the ABC transporter superfamily
MKD39_RS01065	COG0747	negative chemotaxis
MKD39_RS01070	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MKD39_RS01090	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MKD39_RS01100	COG1054	Belongs to the UPF0176 family
MKD39_RS01105	COG3386	PFAM SMP-30 Gluconolaconase
MKD39_RS01110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKD39_RS01130	COG4716	Myosin-crossreactive antigen
MKD39_RS01150	COG1131	(ABC) transporter
MKD39_RS01160	COG1476	TRANSCRIPTIONal
MKD39_RS01165	COG1959	2 iron, 2 sulfur cluster binding
MKD39_RS01170	COG0697	spore germination
MKD39_RS01175	COG2814	Major facilitator Superfamily
MKD39_RS01185	COG0737	Belongs to the 5'-nucleotidase family
MKD39_RS01195	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MKD39_RS01200	COG3639	organic phosphonate transmembrane transporter activity
MKD39_RS01225	COG3391	amine dehydrogenase activity
MKD39_RS01230	COG0201	protein transport
MKD39_RS01240	COG1073	alpha beta
MKD39_RS01250	COG0653	protein targeting
MKD39_RS01265	COG0642	Histidine kinase
MKD39_RS01270	COG0745	RESPONSE REGULATOR receiver
MKD39_RS01295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKD39_RS01315	COG2814	Major facilitator Superfamily
MKD39_RS01330	COG2113	Glycine betaine
MKD39_RS01335	COG2409	Drug exporters of the RND superfamily
MKD39_RS01340	COG0583	DNA-binding transcription factor activity
MKD39_RS01345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MKD39_RS01355	COG1288	antiporter activity
MKD39_RS01360	COG1263	PTS System
MKD39_RS01360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS01360	COG2190	(PTS) system
MKD39_RS01365	COG3942	CHAP domain
MKD39_RS01365	COG1705	Flagellar rod assembly protein muramidase FlgJ
MKD39_RS01365	COG3942	CHAP domain
MKD39_RS01365	COG1705	Flagellar rod assembly protein muramidase FlgJ
MKD39_RS01400	COG2235	arginine
MKD39_RS01410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKD39_RS01435	COG5658	integral membrane protein
MKD39_RS01445	COG3961	Belongs to the TPP enzyme family
MKD39_RS01455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKD39_RS01495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKD39_RS01520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKD39_RS01530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MKD39_RS01535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKD39_RS01540	COG1316	TRANSCRIPTIONal
MKD39_RS01545	COG1785	Belongs to the alkaline phosphatase family
MKD39_RS01565	COG2205	protein histidine kinase activity
MKD39_RS01570	COG1136	(ABC) transporter
MKD39_RS01600	COG0175	sulfate reduction
MKD39_RS01605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKD39_RS01610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKD39_RS01625	COG0730	response to heat
MKD39_RS01630	COG2046	Belongs to the sulfate adenylyltransferase family
MKD39_RS01635	COG0529	Catalyzes the synthesis of activated sulfate
MKD39_RS01640	COG2851	Citrate transporter
MKD39_RS01655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKD39_RS01660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKD39_RS01665	COG1510	regulation of RNA biosynthetic process
MKD39_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS01675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MKD39_RS01685	COG1473	amidohydrolase
MKD39_RS01695	COG1473	amidohydrolase
MKD39_RS01710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKD39_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS01725	COG0583	DNA-binding transcription factor activity
MKD39_RS01735	COG0574	Belongs to the PEP-utilizing enzyme family
MKD39_RS01735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKD39_RS01740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MKD39_RS01745	COG0579	oxidoreductase
MKD39_RS01755	COG2723	6-phospho-beta-galactosidase activity
MKD39_RS01775	COG3588	fructose-bisphosphate aldolase
MKD39_RS01780	COG0563	adenylate kinase activity
MKD39_RS01805	COG1464	Belongs to the NlpA lipoprotein family
MKD39_RS01815	COG0531	amino acid
MKD39_RS01820	COG0028	Belongs to the TPP enzyme family
MKD39_RS01825	COG3527	Alpha-acetolactate decarboxylase
MKD39_RS01865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKD39_RS01875	COG0167	dihydroorotate dehydrogenase activity
MKD39_RS01880	COG3001	Fructosamine kinase
MKD39_RS01915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKD39_RS01940	COG0741	lytic transglycosylase activity
MKD39_RS01950	COG1233	COG1233 Phytoene dehydrogenase and related
MKD39_RS01955	COG0463	Glycosyl transferase, family 2
MKD39_RS01960	COG1562	ergosterol biosynthetic process
MKD39_RS01965	COG1233	COG1233 Phytoene dehydrogenase and related
MKD39_RS01970	COG0436	Aminotransferase
MKD39_RS01980	COG2608	mercury ion transmembrane transporter activity
MKD39_RS01985	COG2217	Heavy metal translocating P-type atpase
MKD39_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS02000	COG0110	maltose O-acetyltransferase activity
MKD39_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS02025	COG0598	Magnesium transport protein CorA
MKD39_RS02035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKD39_RS02040	COG3425	synthase
MKD39_RS02055	COG3942	CHAP domain
MKD39_RS02055	COG1388	LysM domain
MKD39_RS02065	COG0583	DNA-binding transcription factor activity
MKD39_RS02070	COG1380	Effector of murein hydrolase LrgA
MKD39_RS02075	COG1346	cytolysis
MKD39_RS02080	COG0028	Belongs to the TPP enzyme family
MKD39_RS02090	COG2190	(PTS) system
MKD39_RS02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS02090	COG1263	PTS System
MKD39_RS02095	COG1063	alcohol dehydrogenase
MKD39_RS02110	COG0039	L-malate dehydrogenase activity
MKD39_RS02120	COG0697	spore germination
MKD39_RS02130	COG2207	Transcriptional regulator
MKD39_RS02130	COG1917	Cupin 2, conserved barrel domain protein
MKD39_RS02140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MKD39_RS02165	COG1070	Carbohydrate kinase
MKD39_RS02175	COG1760	l-serine dehydratase
MKD39_RS02180	COG1760	l-serine dehydratase
MKD39_RS02195	COG3764	Sortase (surface protein transpeptidase)
MKD39_RS02215	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS02225	COG2514	catechol 2,3-dioxygenase activity
MKD39_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS02245	COG1846	Transcriptional regulator
MKD39_RS02250	COG0346	lactoylglutathione lyase activity
MKD39_RS02255	COG0346	lactoylglutathione lyase activity
MKD39_RS02260	COG0400	carboxylic ester hydrolase activity
MKD39_RS02265	COG3949	Membrane
MKD39_RS02275	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MKD39_RS02280	COG0586	Pfam SNARE associated Golgi protein
MKD39_RS02290	COG2022	thiamine diphosphate biosynthetic process
MKD39_RS02295	COG2104	thiamine diphosphate biosynthetic process
MKD39_RS02295	COG2022	thiamine diphosphate biosynthetic process
MKD39_RS02300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKD39_RS02310	COG2271	Major facilitator Superfamily
MKD39_RS02325	COG4876	unkown
MKD39_RS02330	COG2357	RelA SpoT domain protein
MKD39_RS02345	COG1802	Transcriptional regulator
MKD39_RS02350	COG1070	Carbohydrate kinase
MKD39_RS02355	COG2610	gluconate transmembrane transporter activity
MKD39_RS02365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MKD39_RS02405	COG4221	oxidoreductase activity
MKD39_RS02410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MKD39_RS02415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MKD39_RS02425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MKD39_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS02435	COG1363	Peptidase, m42
MKD39_RS02450	COG0069	glutamate synthase activity
MKD39_RS02465	COG4619	ABC transporter
MKD39_RS02470	COG0390	transport system, permease component
MKD39_RS02475	COG2205	protein histidine kinase activity
MKD39_RS02480	COG0745	RESPONSE REGULATOR receiver
MKD39_RS02490	COG2814	Major facilitator Superfamily
MKD39_RS02495	COG2272	Belongs to the type-B carboxylesterase lipase family
MKD39_RS02500	COG0531	amino acid
MKD39_RS02505	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MKD39_RS02510	COG1063	alcohol dehydrogenase
MKD39_RS02530	COG1174	glycine betaine transport
MKD39_RS02535	COG1346	cytolysis
MKD39_RS02540	COG1380	Effector of murein hydrolase LrgA
MKD39_RS02545	COG3279	Response regulator of the LytR AlgR family
MKD39_RS02550	COG3275	phosphorelay sensor kinase activity
MKD39_RS02560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKD39_RS02570	COG3477	response to acidic pH
MKD39_RS02580	COG0706	membrane insertase activity
MKD39_RS02590	COG0531	amino acid
MKD39_RS02595	COG0025	NhaP-type Na H and K H
MKD39_RS02600	COG1113	amino acid transport
MKD39_RS02620	COG2226	methyltransferase
MKD39_RS02625	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MKD39_RS02630	COG2814	Major facilitator Superfamily
MKD39_RS02640	COG1929	Belongs to the glycerate kinase type-1 family
MKD39_RS02655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKD39_RS02660	COG0741	lytic transglycosylase activity
MKD39_RS02665	COG0588	phosphoglycerate mutase activity
MKD39_RS02675	COG2814	Major facilitator Superfamily
MKD39_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKD39_RS02685	COG0765	amino acid transport
MKD39_RS02690	COG1126	abc transporter atp-binding protein
MKD39_RS02710	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKD39_RS02710	COG3443	Belongs to the bacterial solute-binding protein 9 family
MKD39_RS02715	COG2353	YceI-like domain
MKD39_RS02740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKD39_RS02745	COG2146	nitrite reductase [NAD(P)H] activity
MKD39_RS02755	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MKD39_RS02760	COG1140	nitrate reductase beta subunit
MKD39_RS02765	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MKD39_RS02770	COG2181	nitrate reductase activity
MKD39_RS02780	COG4585	Histidine kinase
MKD39_RS02785	COG2197	response regulator
MKD39_RS02790	COG2223	nitrite transmembrane transporter activity
MKD39_RS02800	COG1846	Transcriptional regulator
MKD39_RS02825	COG3871	stress protein (general stress protein 26)
MKD39_RS02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS02840	COG1263	PTS System
MKD39_RS02855	COG1511	domain protein
MKD39_RS02885	COG0492	ferredoxin-NADP+ reductase activity
MKD39_RS02895	COG0604	alcohol dehydrogenase
MKD39_RS02900	COG2822	iron ion transport
MKD39_RS02905	COG2837	iron assimilation
MKD39_RS02910	COG0672	)-iron permease
MKD39_RS02915	COG0805	protein transport
MKD39_RS02920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKD39_RS02930	COG0463	Glycosyl transferase, family 2
MKD39_RS02930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKD39_RS02935	COG1620	l-lactate permease
MKD39_RS02940	COG0438	transferase activity, transferring glycosyl groups
MKD39_RS02945	COG0579	oxidoreductase
MKD39_RS02960	COG5002	protein histidine kinase activity
MKD39_RS02960	COG3850	Histidine kinase
MKD39_RS02965	COG0745	RESPONSE REGULATOR receiver
MKD39_RS02970	COG0577	efflux transmembrane transporter activity
MKD39_RS02975	COG1136	(ABC) transporter
MKD39_RS02990	COG4640	response to antibiotic
MKD39_RS02995	COG2814	Major facilitator Superfamily
MKD39_RS03005	COG1566	PFAM secretion protein HlyD family protein
MKD39_RS03010	COG2814	Major facilitator Superfamily
MKD39_RS03035	COG0598	Magnesium transport protein CorA
MKD39_RS03040	COG1304	FMN binding
MKD39_RS03045	COG0786	glutamate:sodium symporter activity
MKD39_RS03050	COG2094	Belongs to the DNA glycosylase MPG family
MKD39_RS03065	COG1742	UPF0060 membrane protein
MKD39_RS03075	COG2258	MOSC domain
MKD39_RS03080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MKD39_RS03090	COG1266	CAAX protease self-immunity
MKD39_RS03095	COG0010	Belongs to the arginase family
MKD39_RS03105	COG1473	amidohydrolase
MKD39_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS03115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKD39_RS03130	COG1737	Transcriptional regulator
MKD39_RS03135	COG1263	PTS System
MKD39_RS03135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS03145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKD39_RS03165	COG1113	amino acid transport
MKD39_RS03180	COG1263	PTS System
MKD39_RS03180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS03185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MKD39_RS03200	COG2378	regulation of single-species biofilm formation
MKD39_RS03210	COG1316	TRANSCRIPTIONal
MKD39_RS03215	COG3383	formate dehydrogenase (NAD+) activity
MKD39_RS03220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MKD39_RS03240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKD39_RS03245	COG2076	Multidrug Resistance protein
MKD39_RS03250	COG2076	Multidrug Resistance protein
MKD39_RS03255	COG3942	CHAP domain
MKD39_RS03270	COG1757	Na H antiporter
MKD39_RS03280	COG3942	CHAP domain
MKD39_RS03305	COG1960	acyl-CoA dehydrogenase activity
MKD39_RS03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKD39_RS03315	COG1957	nucleoside hydrolase
MKD39_RS03320	COG1268	BioY protein
MKD39_RS03330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MKD39_RS03335	COG0725	ABC transporter, periplasmic molybdate-binding protein
MKD39_RS03340	COG4149	molybdate abc transporter
MKD39_RS03345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKD39_RS03350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKD39_RS03360	COG0315	cyclic pyranopterin monophosphate synthase activity
MKD39_RS03385	COG0746	molybdenum cofactor guanylyltransferase activity
MKD39_RS03390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKD39_RS03415	COG2348	transferase activity, transferring amino-acyl groups
MKD39_RS03420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKD39_RS03445	COG4975	Glucose uptake
MKD39_RS03455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKD39_RS03455	COG0551	DNA topoisomerase type I activity
MKD39_RS03460	COG2252	PERMEase
MKD39_RS03470	COG0051	transcription antitermination factor activity, RNA binding
MKD39_RS03475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MKD39_RS03480	COG0088	Forms part of the polypeptide exit tunnel
MKD39_RS03485	COG0089	rRNA binding
MKD39_RS03490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MKD39_RS03495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MKD39_RS03500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MKD39_RS03505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MKD39_RS03510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MKD39_RS03515	COG0255	Belongs to the universal ribosomal protein uL29 family
MKD39_RS03520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MKD39_RS03525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MKD39_RS03530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MKD39_RS03535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MKD39_RS03545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MKD39_RS03550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MKD39_RS03555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MKD39_RS03560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MKD39_RS03565	COG1841	ribosomal large subunit assembly
MKD39_RS03570	COG0200	Binds to the 23S rRNA
MKD39_RS03575	COG0201	protein transport
MKD39_RS03580	COG0563	adenylate kinase activity
MKD39_RS03585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MKD39_RS03590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MKD39_RS03595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MKD39_RS03605	COG0202	RNA polymerase activity
MKD39_RS03610	COG0203	ribosomal protein L17
MKD39_RS03615	COG1122	ATPase activity
MKD39_RS03620	COG1122	ATPase activity
MKD39_RS03630	COG0101	tRNA pseudouridine synthase activity
MKD39_RS03635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MKD39_RS03640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MKD39_RS03645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MKD39_RS03650	COG1349	DNA-binding transcription factor activity
MKD39_RS03660	COG1302	Protein conserved in bacteria
MKD39_RS03675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKD39_RS03680	COG0604	alcohol dehydrogenase
MKD39_RS03685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKD39_RS03695	COG2723	6-phospho-beta-galactosidase activity
MKD39_RS03700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKD39_RS03700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKD39_RS03705	COG1447	Phosphotransferase system cellobiose-specific component IIA
MKD39_RS03710	COG3684	Belongs to the aldolase LacD family
MKD39_RS03715	COG1105	Belongs to the carbohydrate kinase PfkB family
MKD39_RS03720	COG0698	ribose 5-phosphate isomerase
MKD39_RS03725	COG0698	ribose 5-phosphate isomerase
MKD39_RS03735	COG4264	IucA IucC family
MKD39_RS03740	COG2814	Major facilitator Superfamily
MKD39_RS03750	COG3457	Alanine racemase
MKD39_RS03755	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MKD39_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS03765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS03770	COG3314	Sporulation integral membrane protein YlbJ
MKD39_RS03775	COG2329	Antibiotic biosynthesis monooxygenase
MKD39_RS03785	COG1988	membrane-bound metal-dependent
MKD39_RS03790	COG4284	Utp--glucose-1-phosphate uridylyltransferase
MKD39_RS03795	COG1272	protein, Hemolysin III
MKD39_RS03810	COG2814	Major facilitator Superfamily
MKD39_RS03815	COG0489	protein tyrosine kinase activity
MKD39_RS03870	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MKD39_RS03880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKD39_RS03890	COG1119	ATPase activity
MKD39_RS03895	COG0561	phosphatase activity
MKD39_RS03920	COG0640	Transcriptional regulator
MKD39_RS03925	COG0702	epimerase
MKD39_RS03930	COG1482	cell wall glycoprotein biosynthetic process
MKD39_RS03950	COG0783	Belongs to the Dps family
MKD39_RS03955	COG0813	purine-nucleoside phosphorylase activity
MKD39_RS03960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MKD39_RS03970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MKD39_RS03980	COG1854	S-ribosylhomocysteine lyase activity
MKD39_RS04000	COG5146	pantothenate kinase activity
MKD39_RS04015	COG0504	CTP synthase activity
MKD39_RS04025	COG0191	fructose-bisphosphate aldolase activity
MKD39_RS04030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKD39_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS04045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MKD39_RS04050	COG0254	rRNA binding
MKD39_RS04055	COG1435	thymidine kinase activity
MKD39_RS04060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MKD39_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
MKD39_RS04070	COG0009	L-threonylcarbamoyladenylate synthase
MKD39_RS04075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKD39_RS04080	COG4475	Protein of unknown function (DUF436)
MKD39_RS04085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKD39_RS04090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MKD39_RS04095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MKD39_RS04105	COG0356	it plays a direct role in the translocation of protons across the membrane
MKD39_RS04110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKD39_RS04115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MKD39_RS04120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKD39_RS04125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MKD39_RS04130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKD39_RS04135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MKD39_RS04140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKD39_RS04150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKD39_RS04155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKD39_RS04165	COG0629	single-stranded DNA binding
MKD39_RS04170	COG1388	LysM domain
MKD39_RS04175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MKD39_RS04185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MKD39_RS04190	COG0352	thiamine-phosphate diphosphorylase activity
MKD39_RS04195	COG0706	membrane insertase activity
MKD39_RS04205	COG1418	mRNA catabolic process
MKD39_RS04210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKD39_RS04215	COG1937	Protein conserved in bacteria
MKD39_RS04235	COG0772	Belongs to the SEDS family
MKD39_RS04240	COG1181	Belongs to the D-alanine--D-alanine ligase family
MKD39_RS04245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKD39_RS04250	COG0513	Belongs to the DEAD box helicase family
MKD39_RS04260	COG3428	Bacterial PH domain
MKD39_RS04265	COG3402	PFAM membrane-flanked domain
MKD39_RS04270	COG0736	holo-[acyl-carrier-protein] synthase activity
MKD39_RS04275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKD39_RS04285	COG2337	Toxic component of a toxin-antitoxin (TA) module
MKD39_RS04290	COG2208	phosphoserine phosphatase activity
MKD39_RS04305	COG1191	sigma factor activity
MKD39_RS04310	COG2183	response to ionizing radiation
MKD39_RS04350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MKD39_RS04355	COG0066	3-isopropylmalate dehydratase activity
MKD39_RS04360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MKD39_RS04365	COG0473	3-isopropylmalate dehydrogenase activity
MKD39_RS04370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKD39_RS04375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MKD39_RS04380	COG0440	acetolactate synthase activity
MKD39_RS04385	COG0028	Belongs to the TPP enzyme family
MKD39_RS04390	COG0129	dihydroxy-acid dehydratase activity
MKD39_RS04395	COG0802	atpase or kinase
MKD39_RS04400	COG1214	PFAM Peptidase M22, glycoprotease
MKD39_RS04405	COG0456	acetyltransferase
MKD39_RS04410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MKD39_RS04415	COG0488	(ABC) transporter
MKD39_RS04420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MKD39_RS04425	COG2391	methyltransferase activity
MKD39_RS04430	COG0425	Belongs to the sulfur carrier protein TusA family
MKD39_RS04435	COG0004	ammonium transporteR
MKD39_RS04440	COG1609	Transcriptional regulator
MKD39_RS04445	COG1621	beta-fructofuranosidase activity
MKD39_RS04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKD39_RS04455	COG3279	Response regulator of the LytR AlgR family
MKD39_RS04470	COG4512	PFAM Accessory gene regulator B
MKD39_RS04495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MKD39_RS04500	COG0459	protein refolding
MKD39_RS04505	COG0582	viral genome integration into host DNA
MKD39_RS04580	COG1725	Transcriptional regulator
MKD39_RS04595	COG1131	(ABC) transporter
MKD39_RS04635	COG2706	6-phosphogluconolactonase activity
MKD39_RS04640	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS04645	COG1227	inorganic diphosphatase activity
MKD39_RS04650	COG1335	isochorismatase
MKD39_RS04660	COG0077	Prephenate dehydratase
MKD39_RS04660	COG1605	Chorismate mutase
MKD39_RS04670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MKD39_RS04675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MKD39_RS04680	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MKD39_RS04690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKD39_RS04695	COG4496	protein, YerC YecD
MKD39_RS04700	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MKD39_RS04705	COG0210	DNA helicase
MKD39_RS04710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKD39_RS04715	COG4851	CamS sex pheromone cAM373 precursor
MKD39_RS04720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKD39_RS04725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKD39_RS04730	COG0154	amidase activity
MKD39_RS04735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MKD39_RS04740	COG1597	lipid kinase activity
MKD39_RS04745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MKD39_RS04755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKD39_RS04765	COG1528	Iron-storage protein
MKD39_RS04780	COG4129	membrane
MKD39_RS04785	COG0024	Methionine aminopeptidase
MKD39_RS04790	COG4221	oxidoreductase activity
MKD39_RS04810	COG4585	Histidine kinase
MKD39_RS04815	COG2197	response regulator
MKD39_RS04820	COG1295	ribonuclease BN
MKD39_RS04830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKD39_RS04835	COG4840	Belongs to the UPF0435 family
MKD39_RS04840	COG2309	aminopeptidase activity
MKD39_RS04845	COG1607	acyl-coa hydrolase
MKD39_RS04855	COG0535	radical SAM domain protein
MKD39_RS04865	COG0693	protein deglycase activity
MKD39_RS04870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKD39_RS04875	COG2137	regulation of response to DNA damage stimulus
MKD39_RS04885	COG1134	teichoic acid transport
MKD39_RS04885	COG1388	LysM domain
MKD39_RS04900	COG1988	membrane-bound metal-dependent
MKD39_RS04905	COG1194	a g-specific adenine glycosylase
MKD39_RS04910	COG3557	Belongs to the UPF0374 family
MKD39_RS04925	COG4129	membrane
MKD39_RS04930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MKD39_RS04935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKD39_RS04940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKD39_RS04945	COG0735	belongs to the Fur family
MKD39_RS05115	COG0765	amino acid transport
MKD39_RS05120	COG1126	abc transporter atp-binding protein
MKD39_RS05125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKD39_RS05135	COG0363	glucosamine-6-phosphate deaminase activity
MKD39_RS05150	COG0114	fumarate hydratase activity
MKD39_RS05155	COG0564	pseudouridine synthase activity
MKD39_RS05160	COG2203	Gaf domain
MKD39_RS05160	COG4585	Histidine kinase
MKD39_RS05165	COG2197	response regulator
MKD39_RS05175	COG4399	Belongs to the UPF0754 family
MKD39_RS05180	COG3679	Belongs to the UPF0342 family
MKD39_RS05190	COG4717	serine-type aminopeptidase activity
MKD39_RS05195	COG3481	metal-dependent phosphohydrolase, HD sub domain
MKD39_RS05200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKD39_RS05215	COG0537	adenosine 5'-monophosphoramidase activity
MKD39_RS05220	COG1131	(ABC) transporter
MKD39_RS05225	COG4473	ABC transporter
MKD39_RS05235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MKD39_RS05240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MKD39_RS05245	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MKD39_RS05295	COG0318	PFAM AMP-dependent synthetase and ligase
MKD39_RS05305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MKD39_RS05310	COG0494	nUDIX hydrolase
MKD39_RS05315	COG1506	peptidase
MKD39_RS05320	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MKD39_RS05325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MKD39_RS05335	COG0656	L-ascorbic acid biosynthetic process
MKD39_RS05340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKD39_RS05345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKD39_RS05355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKD39_RS05380	COG4193	domain, Protein
MKD39_RS05380	COG5632	N-Acetylmuramoyl-L-alanine amidase
MKD39_RS05380	COG3266	domain, Protein
MKD39_RS05395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKD39_RS05395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKD39_RS05400	COG0307	riboflavin synthase, alpha
MKD39_RS05405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKD39_RS05405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKD39_RS05410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MKD39_RS05415	COG0506	proline dehydrogenase activity
MKD39_RS05420	COG2267	carboxylic ester hydrolase activity
MKD39_RS05435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MKD39_RS05440	COG1242	4 iron, 4 sulfur cluster binding
MKD39_RS05445	COG2814	Major facilitator Superfamily
MKD39_RS05450	COG0495	leucyl-tRNA aminoacylation
MKD39_RS05475	COG2081	HI0933 family
MKD39_RS05485	COG2244	polysaccharide biosynthetic process
MKD39_RS05490	COG1187	pseudouridine synthase activity
MKD39_RS05500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MKD39_RS05510	COG0510	thiamine kinase activity
MKD39_RS05515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MKD39_RS05525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKD39_RS05535	COG1363	Peptidase, m42
MKD39_RS05545	COG4848	Belongs to the UPF0354 family
MKD39_RS05550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKD39_RS05555	COG1674	ftsk spoiiie
MKD39_RS05560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKD39_RS05565	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MKD39_RS05575	COG1605	Chorismate mutase
MKD39_RS05575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MKD39_RS05580	COG1609	Transcriptional regulator
MKD39_RS05590	COG0454	-acetyltransferase
MKD39_RS05595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKD39_RS05600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MKD39_RS05610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKD39_RS05620	COG0477	Major facilitator Superfamily
MKD39_RS05625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKD39_RS05630	COG0204	Acyl-transferase
MKD39_RS05635	COG1263	PTS System
MKD39_RS05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS05645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKD39_RS05655	COG1764	response to oxidative stress
MKD39_RS05660	COG0584	glycerophosphoryl diester phosphodiesterase
MKD39_RS05665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MKD39_RS05670	COG1956	GAF domain-containing protein
MKD39_RS05680	COG1104	cysteine desulfurase activity
MKD39_RS05685	COG0301	tRNA thio-modification
MKD39_RS05690	COG0730	response to heat
MKD39_RS05695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MKD39_RS05700	COG0827	DNA restriction-modification system
MKD39_RS05705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKD39_RS05710	COG0589	response to stress
MKD39_RS05715	COG0686	Belongs to the AlaDH PNT family
MKD39_RS05720	COG0006	proline dipeptidase activity
MKD39_RS05725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MKD39_RS05735	COG4109	DRTGG domain
MKD39_RS05740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MKD39_RS05745	COG0587	DNA-directed DNA polymerase activity
MKD39_RS05750	COG0281	malic enzyme
MKD39_RS05755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MKD39_RS05760	COG0825	malonyl-CoA metabolic process
MKD39_RS05765	COG0205	6-phosphofructokinase activity
MKD39_RS05770	COG0469	pyruvate kinase activity
MKD39_RS05780	COG1113	amino acid transport
MKD39_RS05785	COG0372	Belongs to the citrate synthase family
MKD39_RS05790	COG0538	isocitrate dehydrogenase activity
MKD39_RS05795	COG0745	RESPONSE REGULATOR receiver
MKD39_RS05800	COG5002	protein histidine kinase activity
MKD39_RS05805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKD39_RS05805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKD39_RS05815	COG0237	dephospho-CoA kinase activity
MKD39_RS05825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKD39_RS05830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKD39_RS05840	COG1484	DNA-dependent DNA replication
MKD39_RS05845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MKD39_RS05850	COG0833	amino acid
MKD39_RS05855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MKD39_RS05860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MKD39_RS05865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MKD39_RS05870	COG4112	unkown
MKD39_RS05880	COG0544	peptidyl-prolyl cis-trans isomerase activity
MKD39_RS05885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MKD39_RS05895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MKD39_RS05900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MKD39_RS05905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MKD39_RS05910	COG0181	hydroxymethylbilane synthase activity
MKD39_RS05925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MKD39_RS05935	COG2818	Glycosylase
MKD39_RS05940	COG0525	valine-tRNA ligase activity
MKD39_RS05945	COG0285	dihydrofolate synthase activity
MKD39_RS05950	COG2003	Belongs to the UPF0758 family
MKD39_RS05975	COG1792	Involved in formation and maintenance of cell shape
MKD39_RS05985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MKD39_RS05990	COG2868	ribosomal protein
MKD39_RS05995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MKD39_RS06000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MKD39_RS06005	COG4492	Belongs to the UPF0735 family
MKD39_RS06010	COG0632	four-way junction helicase activity
MKD39_RS06015	COG2255	four-way junction helicase activity
MKD39_RS06020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MKD39_RS06025	COG0343	queuine tRNA-ribosyltransferase activity
MKD39_RS06030	COG1862	Preprotein translocase
MKD39_RS06035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKD39_RS06035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKD39_RS06040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MKD39_RS06040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MKD39_RS06045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKD39_RS06050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKD39_RS06055	COG1490	D-aminoacyl-tRNA deacylase activity
MKD39_RS06060	COG0860	N-Acetylmuramoyl-L-alanine amidase
MKD39_RS06065	COG0124	histidyl-tRNA synthetase
MKD39_RS06070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MKD39_RS06080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKD39_RS06085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKD39_RS06090	COG1959	2 iron, 2 sulfur cluster binding
MKD39_RS06100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MKD39_RS06105	COG1104	cysteine desulfurase activity
MKD39_RS06110	COG0482	sulfurtransferase activity
MKD39_RS06120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKD39_RS06125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MKD39_RS06130	COG4472	Bacterial protein of unknown function (DUF965)
MKD39_RS06135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKD39_RS06140	COG3906	Belongs to the UPF0473 family
MKD39_RS06150	COG0826	peptidase U32
MKD39_RS06155	COG0826	peptidase U32
MKD39_RS06160	COG0572	uridine kinase
MKD39_RS06165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKD39_RS06170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MKD39_RS06175	COG1984	allophanate hydrolase subunit 2
MKD39_RS06180	COG0511	ligase activity, forming carbon-carbon bonds
MKD39_RS06185	COG0439	Biotin carboxylase
MKD39_RS06190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MKD39_RS06195	COG1914	H( )-stimulated, divalent metal cation uptake system
MKD39_RS06200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKD39_RS06205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MKD39_RS06210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKD39_RS06215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MKD39_RS06220	COG1534	Rna-binding protein
MKD39_RS06225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MKD39_RS06230	COG1713	HD superfamily hydrolase involved in NAD metabolism
MKD39_RS06235	COG0799	negative regulation of ribosome biogenesis
MKD39_RS06240	COG2226	methyltransferase
MKD39_RS06245	COG1596	polysaccharide export
MKD39_RS06245	COG1555	photosystem II stabilization
MKD39_RS06250	COG2131	deaminase
MKD39_RS06255	COG2333	competence protein COMEC
MKD39_RS06255	COG0658	competence protein
MKD39_RS06260	COG1466	dna polymerase III delta subunit
MKD39_RS06270	COG0268	Binds directly to 16S ribosomal RNA
MKD39_RS06275	COG0481	GTPase activity
MKD39_RS06280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKD39_RS06285	COG1420	regulation of RNA biosynthetic process
MKD39_RS06290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MKD39_RS06295	COG0443	Heat shock 70 kDa protein
MKD39_RS06300	COG0484	heat shock protein binding
MKD39_RS06305	COG2264	protein methyltransferase activity
MKD39_RS06310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKD39_RS06315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKD39_RS06325	COG1030	water channel activity
MKD39_RS06330	COG4864	UPF0365 protein
MKD39_RS06340	COG1702	phosphate starvation-inducible protein PhoH
MKD39_RS06345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MKD39_RS06350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKD39_RS06360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKD39_RS06365	COG1381	Involved in DNA repair and RecF pathway recombination
MKD39_RS06370	COG0423	glycine-tRNA ligase activity
MKD39_RS06375	COG0517	IMP dehydrogenase activity
MKD39_RS06380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MKD39_RS06390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKD39_RS06395	COG2384	SAM-dependent methyltransferase
MKD39_RS06400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MKD39_RS06405	COG0513	Belongs to the DEAD box helicase family
MKD39_RS06410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MKD39_RS06415	COG1121	(ABC) transporter
MKD39_RS06420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKD39_RS06435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MKD39_RS06440	COG0768	penicillin binding
MKD39_RS06445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MKD39_RS06450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKD39_RS06460	COG4483	Protein conserved in bacteria
MKD39_RS06465	COG1940	carbohydrate kinase activity
MKD39_RS06470	COG0011	TIGRFAM Protein of
MKD39_RS06475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKD39_RS06480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKD39_RS06485	COG1459	type II secretion system
MKD39_RS06490	COG4537	Required for transformation and DNA binding
MKD39_RS06500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MKD39_RS06505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MKD39_RS06510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKD39_RS06515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKD39_RS06520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKD39_RS06525	COG0095	Lipoate-protein ligase
MKD39_RS06540	COG0006	proline dipeptidase activity
MKD39_RS06545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MKD39_RS06550	COG0511	ligase activity, forming carbon-carbon bonds
MKD39_RS06555	COG0439	Biotin carboxylase
MKD39_RS06560	COG1302	Protein conserved in bacteria
MKD39_RS06565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKD39_RS06570	COG1570	exodeoxyribonuclease VII activity
MKD39_RS06575	COG1722	exodeoxyribonuclease VII activity
MKD39_RS06585	COG1438	arginine binding
MKD39_RS06590	COG0497	DNA recombination
MKD39_RS06595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKD39_RS06600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MKD39_RS06605	COG0022	dehydrogenase e1 component
MKD39_RS06610	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKD39_RS06620	COG4129	membrane
MKD39_RS06635	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKD39_RS06645	COG1609	Transcriptional regulator
MKD39_RS06650	COG0366	Alpha amylase catalytic
MKD39_RS06665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKD39_RS06670	COG1234	tRNA 3'-trailer cleavage
MKD39_RS06675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKD39_RS06695	COG0300	oxidoreductase activity
MKD39_RS06705	COG0667	Aldo Keto reductase
MKD39_RS06710	COG0494	nUDIX hydrolase
MKD39_RS06715	COG0735	belongs to the Fur family
MKD39_RS06720	COG4974	Belongs to the 'phage' integrase family
MKD39_RS06730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MKD39_RS06735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MKD39_RS06740	COG1187	pseudouridine synthase activity
MKD39_RS06745	COG0745	RESPONSE REGULATOR receiver
MKD39_RS06760	COG1141	Ferredoxin
MKD39_RS06770	COG0514	ATP-dependent DNA helicase (RecQ)
MKD39_RS06775	COG1388	LysM domain
MKD39_RS06785	COG0492	ferredoxin-NADP+ reductase activity
MKD39_RS06795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MKD39_RS06800	COG0539	negative regulation of cytoplasmic translation
MKD39_RS06805	COG1160	GTP binding
MKD39_RS06810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MKD39_RS06830	COG2226	methyltransferase
MKD39_RS06835	COG0142	geranyltranstransferase activity
MKD39_RS06840	COG0105	UTP biosynthetic process
MKD39_RS06845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MKD39_RS06850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MKD39_RS06855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MKD39_RS06860	COG0457	Tetratricopeptide repeat
MKD39_RS06865	COG5582	Belongs to the UPF0302 family
MKD39_RS06870	COG4347	Protein of unknown function (DUF1405)
MKD39_RS06875	COG2738	Putative neutral zinc metallopeptidase
MKD39_RS06880	COG1694	Mazg nucleotide pyrophosphohydrolase
MKD39_RS06885	COG0438	transferase activity, transferring glycosyl groups
MKD39_RS06890	COG0617	tRNA 3'-terminal CCA addition
MKD39_RS06900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKD39_RS06900	COG1199	ATP-dependent helicase activity
MKD39_RS06905	COG0017	Asparaginyl-tRNA synthetase
MKD39_RS06910	COG3935	DnaD domain protein
MKD39_RS06915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKD39_RS06925	COG4499	WXG100 protein secretion system (Wss), protein YukC
MKD39_RS06925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKD39_RS06930	COG3331	DNA recombination
MKD39_RS06940	COG4474	Belongs to the UPF0398 family
MKD39_RS06945	COG3599	regulation of cell shape
MKD39_RS06955	COG0116	Belongs to the methyltransferase superfamily
MKD39_RS06965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MKD39_RS06970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKD39_RS06995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MKD39_RS07005	COG1413	lyase activity
MKD39_RS07010	COG1413	lyase activity
MKD39_RS07020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MKD39_RS07040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKD39_RS07045	COG2190	(PTS) system
MKD39_RS07050	COG4479	Belongs to the UPF0346 family
MKD39_RS07055	COG0793	Belongs to the peptidase S41A family
MKD39_RS07065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MKD39_RS07070	COG0671	phosphoesterase, PA-phosphatase related
MKD39_RS07080	COG0745	RESPONSE REGULATOR receiver
MKD39_RS07085	COG5002	protein histidine kinase activity
MKD39_RS07090	COG0567	Dehydrogenase, E1 component
MKD39_RS07095	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKD39_RS07120	COG0714	Associated with various cellular activities
MKD39_RS07125	COG4548	von Willebrand factor, type A
MKD39_RS07130	COG1114	Component of the transport system for branched-chain amino acids
MKD39_RS07135	COG3853	Toxic anion resistance protein (TelA)
MKD39_RS07145	COG1254	Belongs to the acylphosphatase family
MKD39_RS07155	COG1278	Cold shock
MKD39_RS07175	COG1473	amidohydrolase
MKD39_RS07180	COG2171	N-acyltransferase activity
MKD39_RS07185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MKD39_RS07190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKD39_RS07195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKD39_RS07205	COG0488	(ABC) transporter
MKD39_RS07210	COG2996	Protein conserved in bacteria
MKD39_RS07215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MKD39_RS07220	COG0573	inorganic phosphate transmembrane transporter activity
MKD39_RS07225	COG0581	inorganic phosphate transmembrane transporter activity
MKD39_RS07230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKD39_RS07235	COG0704	Plays a role in the regulation of phosphate uptake
MKD39_RS07240	COG1164	Oligoendopeptidase f
MKD39_RS07250	COG4607	ABC-type enterochelin transport system periplasmic component
MKD39_RS07255	COG0561	phosphatase activity
MKD39_RS07260	COG2348	transferase activity, transferring amino-acyl groups
MKD39_RS07265	COG2348	transferase activity, transferring amino-acyl groups
MKD39_RS07275	COG0159	tryptophan synthase activity
MKD39_RS07285	COG0135	phosphoribosylanthranilate isomerase activity
MKD39_RS07290	COG0134	indole-3-glycerol-phosphate synthase activity
MKD39_RS07295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKD39_RS07300	COG0512	Glutamine amidotransferase of anthranilate synthase
MKD39_RS07305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKD39_RS07310	COG1363	Peptidase, m42
MKD39_RS07315	COG0287	Prephenate dehydrogenase
MKD39_RS07320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKD39_RS07325	COG1942	4-Oxalocrotonate Tautomerase
MKD39_RS07340	COG0392	lysyltransferase activity
MKD39_RS07340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MKD39_RS07345	COG0628	permease
MKD39_RS07350	COG3711	transcriptional antiterminator
MKD39_RS07355	COG1115	amino acid carrier protein
MKD39_RS07360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKD39_RS07365	COG0187	DNA topoisomerase II activity
MKD39_RS07370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MKD39_RS07375	COG4841	protein insertion into membrane
MKD39_RS07380	COG0824	Thioesterase
MKD39_RS07385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MKD39_RS07390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKD39_RS07395	COG1970	mechanosensitive ion channel activity
MKD39_RS07400	COG0419	ATPase involved in DNA repair
MKD39_RS07405	COG0420	3'-5' exonuclease activity
MKD39_RS07410	COG4846	Membrane protein involved in cytochrome C biogenesis
MKD39_RS07425	COG4224	UPF0291 protein
MKD39_RS07435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKD39_RS07440	COG2340	Cysteine-rich secretory protein family
MKD39_RS07445	COG0516	GMP reductase activity
MKD39_RS07450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MKD39_RS07460	COG0753	catalase activity
MKD39_RS07465	COG0833	amino acid
MKD39_RS07480	COG0083	homoserine kinase activity
MKD39_RS07485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKD39_RS07490	COG0460	homoserine dehydrogenase
MKD39_RS07495	COG0527	aspartate kinase activity
MKD39_RS07525	COG2197	response regulator
MKD39_RS07530	COG4585	Histidine kinase
MKD39_RS07540	COG1131	(ABC) transporter
MKD39_RS07545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKD39_RS07605	COG4824	toxin secretion phage lysis holin
MKD39_RS07640	COG3953	SLT domain
MKD39_RS07640	COG5412	phage tail tape measure protein
MKD39_RS07690	COG0740	serine-type endopeptidase activity
MKD39_RS07780	COG1484	DNA-dependent DNA replication
MKD39_RS07865	COG0789	Transcriptional regulator
MKD39_RS07870	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MKD39_RS07875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKD39_RS07880	COG0386	Belongs to the glutathione peroxidase family
MKD39_RS07885	COG1923	regulation of RNA biosynthetic process
MKD39_RS07890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MKD39_RS07900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MKD39_RS07905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MKD39_RS07910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MKD39_RS07920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKD39_RS07925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKD39_RS07935	COG4550	Control of competence regulator ComK, YlbF/YmcA
MKD39_RS07940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKD39_RS07950	COG4195	phage-related replication protein
MKD39_RS07955	COG1013	pyruvate-flavodoxin oxidoreductase activity
MKD39_RS07960	COG0674	pyruvate-flavodoxin oxidoreductase activity
MKD39_RS07960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MKD39_RS07965	COG1692	metallophosphoesterase
MKD39_RS07975	COG1418	mRNA catabolic process
MKD39_RS07990	COG0456	acetyltransferase
MKD39_RS08000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKD39_RS08005	COG1058	Belongs to the CinA family
MKD39_RS08005	COG1546	Belongs to the CinA family
MKD39_RS08025	COG0300	oxidoreductase activity
MKD39_RS08030	COG0612	Peptidase, M16
MKD39_RS08035	COG0612	Peptidase, M16
MKD39_RS08040	COG2188	Transcriptional regulator
MKD39_RS08045	COG1674	ftsk spoiiie
MKD39_RS08050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MKD39_RS08055	COG1185	polyribonucleotide nucleotidyltransferase activity
MKD39_RS08060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MKD39_RS08065	COG0196	riboflavin kinase activity
MKD39_RS08070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MKD39_RS08075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MKD39_RS08080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MKD39_RS08085	COG1358	cellular component organization or biogenesis
MKD39_RS08090	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MKD39_RS08095	COG0195	Participates in both transcription termination and antitermination
MKD39_RS08100	COG0779	Required for maturation of 30S ribosomal subunits
MKD39_RS08105	COG2176	DNA-directed DNA polymerase activity
MKD39_RS08110	COG0442	prolyl-tRNA aminoacylation
MKD39_RS08120	COG4589	Belongs to the CDS family
MKD39_RS08125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKD39_RS08130	COG0233	cytoplasmic translational termination
MKD39_RS08135	COG0528	UMP kinase activity
MKD39_RS08140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MKD39_RS08145	COG0052	Belongs to the universal ribosomal protein uS2 family
MKD39_RS08150	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MKD39_RS08155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MKD39_RS08160	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MKD39_RS08165	COG4974	Belongs to the 'phage' integrase family
MKD39_RS08170	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MKD39_RS08175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKD39_RS08180	COG0758	DNA mediated transformation
MKD39_RS08190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MKD39_RS08195	COG0045	succinate-CoA ligase (ADP-forming) activity
MKD39_RS08200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKD39_RS08210	COG4485	Bacterial membrane protein, YfhO
MKD39_RS08220	COG0335	large ribosomal subunit rRNA binding
MKD39_RS08225	COG0336	Belongs to the RNA methyltransferase TrmD family
MKD39_RS08230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MKD39_RS08235	COG0228	four-way junction DNA binding
MKD39_RS08240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKD39_RS08245	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MKD39_RS08250	COG0552	protein localization to endoplasmic reticulum
MKD39_RS08255	COG1196	nuclear chromosome segregation
MKD39_RS08260	COG0571	ribonuclease III activity
MKD39_RS08265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKD39_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
MKD39_RS08280	COG0416	fatty acid biosynthetic process
MKD39_RS08285	COG1349	DNA-binding transcription factor activity
MKD39_RS08300	COG1461	Dihydroxyacetone kinase
MKD39_RS08305	COG1302	Protein conserved in bacteria
MKD39_RS08310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MKD39_RS08315	COG1564	THIamine pyrophosphokinase
MKD39_RS08320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKD39_RS08325	COG1162	GTPase activity
MKD39_RS08335	COG0631	protein serine/threonine phosphatase activity
MKD39_RS08340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MKD39_RS08345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKD39_RS08345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKD39_RS08350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MKD39_RS08365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKD39_RS08370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKD39_RS08375	COG1758	RNA polymerase activity
MKD39_RS08380	COG0194	GDP metabolic process
MKD39_RS08400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MKD39_RS08405	COG0284	orotidine-5'-phosphate decarboxylase activity
MKD39_RS08410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MKD39_RS08415	COG0505	Belongs to the CarA family
MKD39_RS08425	COG0540	Belongs to the ATCase OTCase family
MKD39_RS08430	COG2233	PERMEase
MKD39_RS08435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MKD39_RS08440	COG0564	pseudouridine synthase activity
MKD39_RS08445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MKD39_RS08450	COG1388	LysM domain
MKD39_RS08450	COG3942	CHAP domain
MKD39_RS08460	COG0702	epimerase
MKD39_RS08465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MKD39_RS08470	COG3599	regulation of cell shape
MKD39_RS08480	COG0762	integral membrane protein
MKD39_RS08485	COG1799	cell septum assembly
MKD39_RS08490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MKD39_RS08495	COG1496	oxidoreductase activity
MKD39_RS08500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKD39_RS08505	COG0849	cell division
MKD39_RS08510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKD39_RS08515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MKD39_RS08520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKD39_RS08525	COG0768	penicillin binding
MKD39_RS08530	COG4839	cell division protein FtsL
MKD39_RS08535	COG0275	rRNA processing
MKD39_RS08540	COG2001	Belongs to the MraZ family
MKD39_RS08545	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MKD39_RS08550	COG0454	-acetyltransferase
MKD39_RS08555	COG1011	Hydrolase
MKD39_RS08595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MKD39_RS08600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MKD39_RS08605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKD39_RS08610	COG1053	succinate dehydrogenase
MKD39_RS08615	COG2009	succinate dehydrogenase
MKD39_RS08620	COG0322	excinuclease ABC activity
MKD39_RS08625	COG3118	belongs to the thioredoxin family
MKD39_RS08630	COG1193	negative regulation of DNA recombination
MKD39_RS08635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MKD39_RS08635	COG1796	DNA polymerase
MKD39_RS08645	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MKD39_RS08650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKD39_RS08655	COG0072	phenylalanine-tRNA ligase activity
MKD39_RS08655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKD39_RS08660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MKD39_RS08665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKD39_RS08670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MKD39_RS08680	COG1323	Belongs to the UPF0348 family
MKD39_RS08685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MKD39_RS08690	COG0742	ribosomal rna small subunit methyltransferase
MKD39_RS08700	COG4471	UPF0298 protein
MKD39_RS08710	COG3679	Belongs to the UPF0342 family
MKD39_RS08715	COG2340	Cysteine-rich secretory protein family
MKD39_RS08725	COG0109	protoheme IX farnesyltransferase activity
MKD39_RS08730	COG1612	heme a metabolic process
MKD39_RS08740	COG0772	Belongs to the SEDS family
MKD39_RS08745	COG4838	Belongs to the UPF0358 family
MKD39_RS08750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKD39_RS08755	COG4896	Protein conserved in bacteria
MKD39_RS08760	COG1217	gtp-binding protein TYPA
MKD39_RS08770	COG0483	inositol monophosphate 1-phosphatase activity
MKD39_RS08775	COG4493	Belongs to the UPF0637 family
MKD39_RS08780	COG1914	H( )-stimulated, divalent metal cation uptake system
MKD39_RS08800	COG1177	transmembrane transport
MKD39_RS08805	COG1176	ABC-type spermidine putrescine transport system, permease component I
MKD39_RS08810	COG3842	ATPase activity
MKD39_RS08815	COG1396	sequence-specific DNA binding
MKD39_RS08815	COG3800	Transcriptional regulator
MKD39_RS08820	COG4476	Belongs to the UPF0223 family
MKD39_RS08850	COG0242	peptide deformylase activity
MKD39_RS08855	COG5503	Protein of unknown function (DUF1447)
MKD39_RS08860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MKD39_RS08870	COG2832	Protein of unknown function (DUF454)
MKD39_RS08875	COG0569	domain protein
MKD39_RS08880	COG1294	oxidase, subunit
MKD39_RS08885	COG1271	oxidase subunit
MKD39_RS08905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKD39_RS08920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKD39_RS08940	COG1122	ATPase activity
MKD39_RS08945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MKD39_RS08950	COG0151	Belongs to the GarS family
MKD39_RS08955	COG0138	bifunctional purine biosynthesis protein purh
MKD39_RS08965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MKD39_RS08975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKD39_RS08980	COG0047	phosphoribosylformylglycinamidine synthase activity
MKD39_RS08985	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKD39_RS08990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MKD39_RS08995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MKD39_RS09000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MKD39_RS09005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MKD39_RS09020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKD39_RS09025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKD39_RS09030	COG1845	cytochrome c oxidase, subunit III
MKD39_RS09035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MKD39_RS09045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MKD39_RS09050	COG1316	TRANSCRIPTIONal
MKD39_RS09080	COG3594	Acyltransferase
MKD39_RS09085	COG0436	Aminotransferase
MKD39_RS09090	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MKD39_RS09095	COG0596	Alpha beta hydrolase
MKD39_RS09100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MKD39_RS09105	COG1169	isochorismate synthase
MKD39_RS09110	COG1575	Belongs to the MenA family. Type 1 subfamily
MKD39_RS09175	COG4873	Protein conserved in bacteria
MKD39_RS09195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKD39_RS09200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKD39_RS09205	COG0861	Integral membrane protein TerC family
MKD39_RS09210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MKD39_RS09220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MKD39_RS09225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MKD39_RS09230	COG2814	Major facilitator Superfamily
MKD39_RS09235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MKD39_RS09240	COG2382	esterase
MKD39_RS09245	COG0628	permease
MKD39_RS09255	COG0475	glutathione-regulated potassium exporter activity
MKD39_RS09255	COG0569	domain protein
MKD39_RS09260	COG2239	Acts as a magnesium transporter
MKD39_RS09265	COG0564	pseudouridine synthase activity
MKD39_RS09270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKD39_RS09275	COG2357	RelA SpoT domain protein
MKD39_RS09285	COG4116	CYTH
MKD39_RS09290	COG2346	COG2346, Truncated hemoglobins
MKD39_RS09295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MKD39_RS09300	COG1164	Oligoendopeptidase f
MKD39_RS09310	COG4862	establishment of competence for transformation
MKD39_RS09315	COG1393	Belongs to the ArsC family
MKD39_RS09320	COG0180	Tryptophanyl-tRNA synthetase
MKD39_RS09335	COG4166	transmembrane transport
MKD39_RS09355	COG0444	Belongs to the ABC transporter superfamily
MKD39_RS09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKD39_RS09365	COG0601	transmembrane transport
MKD39_RS09380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKD39_RS09390	COG0542	response to heat
MKD39_RS09405	COG0561	phosphatase activity
MKD39_RS09410	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKD39_RS09420	COG0179	Fumarylacetoacetate (FAA) hydrolase
MKD39_RS09425	COG1074	ATP-dependent DNA helicase activity
MKD39_RS09430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MKD39_RS09445	COG0398	Pfam SNARE associated Golgi protein
MKD39_RS09450	COG0166	Belongs to the GPI family
MKD39_RS09455	COG0137	argininosuccinate synthase activity
MKD39_RS09460	COG0165	Argininosuccinate lyase
MKD39_RS09465	COG0584	glycerophosphoryl diester phosphodiesterase
MKD39_RS09480	COG1902	pentaerythritol trinitrate reductase activity
MKD39_RS09485	COG1098	S1 RNA binding domain
MKD39_RS09490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKD39_RS09500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKD39_RS09500	COG2111	Na H antiporter
MKD39_RS09505	COG2111	Na H antiporter
MKD39_RS09510	COG1006	Multisubunit Na H antiporter MnhC subunit
MKD39_RS09515	COG0651	ATP synthesis coupled electron transport
MKD39_RS09520	COG1863	multisubunit Na H antiporter MnhE subunit
MKD39_RS09525	COG2212	antiporter activity
MKD39_RS09530	COG1320	monovalent cation:proton antiporter activity
MKD39_RS09540	COG2050	protein possibly involved in aromatic compounds catabolism
MKD39_RS09545	COG2056	Na+-H+ antiporter family
MKD39_RS09550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MKD39_RS09555	COG1252	NADH dehydrogenase
MKD39_RS09560	COG0316	Belongs to the HesB IscA family
MKD39_RS09565	COG4844	belongs to the
MKD39_RS09570	COG1252	NADH dehydrogenase
MKD39_RS09575	COG4837	Protein of unknown function (DUF1462)
MKD39_RS09580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MKD39_RS09590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MKD39_RS09595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKD39_RS09600	COG1696	Membrane protein involved in D-alanine export
MKD39_RS09605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKD39_RS09620	COG0647	UMP catabolic process
MKD39_RS09625	COG2445	Protein of unknown function DUF86
MKD39_RS09635	COG4470	Protein conserved in bacteria
MKD39_RS09640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKD39_RS09645	COG0737	Belongs to the 5'-nucleotidase family
MKD39_RS09650	COG0730	response to heat
MKD39_RS09655	COG1801	Protein of unknown function DUF72
MKD39_RS09660	COG2070	2-Nitropropane dioxygenase
MKD39_RS09670	COG0719	Fe-S assembly protein
MKD39_RS09675	COG0822	iron-sulfur transferase activity
MKD39_RS09685	COG0719	Fe-S assembly protein
MKD39_RS09690	COG0396	ATPase activity
MKD39_RS09705	COG3237	CsbD-like
MKD39_RS09715	COG1464	Belongs to the NlpA lipoprotein family
MKD39_RS09720	COG2011	ABC-type metal ion transport system permease component
MKD39_RS09725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKD39_RS09735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MKD39_RS09740	COG0509	glycine decarboxylation via glycine cleavage system
MKD39_RS09745	COG1393	Belongs to the ArsC family
MKD39_RS09750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKD39_RS09760	COG0710	3-dehydroquinate dehydratase activity
MKD39_RS09765	COG1764	response to oxidative stress
MKD39_RS09775	COG1279	arginine transmembrane transporter activity
MKD39_RS09780	COG0406	alpha-ribazole phosphatase activity
MKD39_RS09820	COG0456	acetyltransferase
MKD39_RS09825	COG4195	phage-related replication protein
MKD39_RS09885	COG5484	DNA packaging
MKD39_RS09885	COG3728	DNA packaging
MKD39_RS09980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MKD39_RS09985	COG0557	exoribonuclease II activity
MKD39_RS09990	COG1647	Serine aminopeptidase, S33
MKD39_RS09995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKD39_RS10005	COG0148	phosphopyruvate hydratase activity
MKD39_RS10010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MKD39_RS10015	COG0149	triose-phosphate isomerase activity
MKD39_RS10020	COG0126	phosphoglycerate kinase activity
MKD39_RS10030	COG2390	Transcriptional regulator
MKD39_RS10050	COG1090	epimerase
MKD39_RS10060	COG0740	serine-type endopeptidase activity
MKD39_RS10065	COG1481	regulation of sporulation
MKD39_RS10070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MKD39_RS10075	COG1660	Displays ATPase and GTPase activities
MKD39_RS10080	COG0492	ferredoxin-NADP+ reductase activity
MKD39_RS10095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MKD39_RS10100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MKD39_RS10105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MKD39_RS10110	COG0556	nucleotide-excision repair
MKD39_RS10125	COG0300	oxidoreductase activity
MKD39_RS10130	COG1388	LysM domain
MKD39_RS10130	COG3942	CHAP domain
MKD39_RS10140	COG0653	protein targeting
MKD39_RS10145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKD39_RS10150	COG1040	competence protein
MKD39_RS10155	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MKD39_RS10165	COG1739	Uncharacterized protein family UPF0029
MKD39_RS10170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKD39_RS10175	COG2199	diguanylate cyclase activity
MKD39_RS10190	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKD39_RS10195	COG1929	Belongs to the glycerate kinase type-1 family
MKD39_RS10215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MKD39_RS10230	COG4607	ABC-type enterochelin transport system periplasmic component
MKD39_RS10235	COG4604	ABC transporter, ATP-binding protein
MKD39_RS10240	COG4605	iron ion homeostasis
MKD39_RS10245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS10250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKD39_RS10255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKD39_RS10260	COG1780	Probably involved in ribonucleotide reductase function
MKD39_RS10270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKD39_RS10275	COG3104	oligopeptide transport
MKD39_RS10280	COG1597	lipid kinase activity
MKD39_RS10290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKD39_RS10295	COG3104	oligopeptide transport
MKD39_RS10300	COG1174	glycine betaine transport
MKD39_RS10315	COG0488	(ABC) transporter
MKD39_RS10325	COG1368	sulfuric ester hydrolase activity
MKD39_RS10330	COG1984	allophanate hydrolase subunit 2
MKD39_RS10335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MKD39_RS10355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKD39_RS10355	COG0512	Glutamine amidotransferase of anthranilate synthase
MKD39_RS10360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MKD39_RS10365	COG0720	synthase
MKD39_RS10370	COG0602	queuosine metabolic process
MKD39_RS10380	COG0463	Glycosyl transferase, family 2
MKD39_RS10390	COG0656	L-ascorbic acid biosynthetic process
MKD39_RS10395	COG1253	flavin adenine dinucleotide binding
MKD39_RS10400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKD39_RS10400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKD39_RS10400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKD39_RS10405	COG1105	Belongs to the carbohydrate kinase PfkB family
MKD39_RS10410	COG1349	DNA-binding transcription factor activity
MKD39_RS10415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKD39_RS10445	COG0415	Belongs to the DNA photolyase family
MKD39_RS10450	COG0471	metal ion transport
MKD39_RS10460	COG0523	cobalamin synthesis protein
MKD39_RS10470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MKD39_RS10475	COG4988	ABC transporter
MKD39_RS10480	COG1968	undecaprenyl-diphosphatase activity
MKD39_RS10490	COG1671	Belongs to the UPF0178 family
MKD39_RS10495	COG1611	Belongs to the LOG family
MKD39_RS10500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKD39_RS10515	COG0456	acetyltransferase
MKD39_RS10525	COG2839	Protein conserved in bacteria
MKD39_RS10535	COG0583	DNA-binding transcription factor activity
MKD39_RS10545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MKD39_RS10555	COG0217	transcriptional regulatory protein
MKD39_RS10575	COG1388	LysM domain
MKD39_RS10575	COG3942	CHAP domain
MKD39_RS10580	COG0306	phosphate transporter
MKD39_RS10585	COG1392	Phosphate transport regulator
MKD39_RS10590	COG0577	efflux transmembrane transporter activity
MKD39_RS10595	COG1136	(ABC) transporter
MKD39_RS10600	COG2205	protein histidine kinase activity
MKD39_RS10605	COG0745	RESPONSE REGULATOR receiver
MKD39_RS10610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKD39_RS10620	COG0657	acetylesterase activity
MKD39_RS10625	COG3949	Membrane
MKD39_RS10635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MKD39_RS10645	COG2376	Dihydroxyacetone kinase
MKD39_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS10655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS10660	COG1120	ATPase activity
MKD39_RS10665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKD39_RS10670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKD39_RS10675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKD39_RS10675	COG0463	Glycosyl transferase, family 2
MKD39_RS10680	COG0438	transferase activity, transferring glycosyl groups
MKD39_RS10690	COG1132	(ABC) transporter
MKD39_RS10700	COG1686	Belongs to the peptidase S11 family
MKD39_RS10705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MKD39_RS10715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MKD39_RS10720	COG1682	transport, permease protein
MKD39_RS10725	COG1134	teichoic acid transport
MKD39_RS10730	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MKD39_RS10745	COG1321	iron dependent repressor
MKD39_RS10765	COG1320	monovalent cation:proton antiporter activity
MKD39_RS10770	COG2212	antiporter activity
MKD39_RS10775	COG1863	multisubunit Na H antiporter MnhE subunit
MKD39_RS10780	COG0651	ATP synthesis coupled electron transport
MKD39_RS10785	COG1006	Multisubunit Na H antiporter MnhC subunit
MKD39_RS10790	COG2111	Na H antiporter
MKD39_RS10795	COG2111	Na H antiporter
MKD39_RS10795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKD39_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKD39_RS10865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKD39_RS10880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKD39_RS10885	COG0018	arginyl-trna synthetase
MKD39_RS10935	COG0456	acetyltransferase
MKD39_RS10965	COG1131	(ABC) transporter
MKD39_RS10975	COG3173	Aminoglycoside phosphotransferase
MKD39_RS10985	COG3226	Transcriptional regulator
MKD39_RS11020	COG3093	addiction module antidote protein HigA
MKD39_RS11080	COG1078	dGTPase activity
MKD39_RS11090	COG0655	NAD(P)H dehydrogenase (quinone) activity
MKD39_RS11095	COG0667	Aldo Keto reductase
MKD39_RS11105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKD39_RS11110	COG1278	Cold shock
MKD39_RS11115	COG4844	belongs to the
MKD39_RS11140	COG0095	Lipoate-protein ligase
MKD39_RS11150	COG3253	May function as heme-dependent peroxidase
MKD39_RS11155	COG2966	Psort location CytoplasmicMembrane, score
MKD39_RS11170	COG2363	Small membrane protein
MKD39_RS11180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MKD39_RS11195	COG0477	Major facilitator Superfamily
MKD39_RS11210	COG0183	Belongs to the thiolase family
MKD39_RS11215	COG0318	PFAM AMP-dependent synthetase and ligase
MKD39_RS11220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MKD39_RS11225	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MKD39_RS11235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MKD39_RS11240	COG1469	GTP cyclohydrolase I activity
MKD39_RS11280	COG0431	NADPH-dependent FMN reductase
MKD39_RS11285	COG0561	phosphatase activity
MKD39_RS11295	COG1428	Deoxynucleoside kinase
MKD39_RS11300	COG1428	Deoxynucleoside kinase
MKD39_RS11305	COG0546	phosphoglycolate phosphatase activity
MKD39_RS11315	COG3177	Filamentation induced by cAMP protein fic
MKD39_RS11345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKD39_RS11350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKD39_RS11355	COG0737	Belongs to the 5'-nucleotidase family
MKD39_RS11380	COG1473	amidohydrolase
MKD39_RS11390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKD39_RS11395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKD39_RS11405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MKD39_RS11415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKD39_RS11420	COG0085	RNA polymerase activity
MKD39_RS11425	COG2813	Specifically methylates the guanine in position
MKD39_RS11430	COG0222	ribosome binding
MKD39_RS11435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MKD39_RS11445	COG0081	regulation of translation
MKD39_RS11450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MKD39_RS11455	COG0250	Participates in transcription elongation, termination and antitermination
MKD39_RS11460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKD39_RS11465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MKD39_RS11475	COG3688	RNA-binding protein containing a PIN domain
MKD39_RS11480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKD39_RS11485	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MKD39_RS11490	COG0215	cysteine-tRNA ligase activity
MKD39_RS11495	COG1045	serine acetyltransferase
MKD39_RS11500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKD39_RS11505	COG4956	integral membrane protein (PIN domain superfamily)
MKD39_RS11510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKD39_RS11515	COG0542	response to heat
MKD39_RS11520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MKD39_RS11525	COG3880	PFAM UvrB UvrC protein
MKD39_RS11530	COG4463	regulation of RNA biosynthetic process
MKD39_RS11535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKD39_RS11540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MKD39_RS11545	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MKD39_RS11550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKD39_RS11555	COG2259	Doxx family
MKD39_RS11640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MKD39_RS11645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKD39_RS11660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKD39_RS11665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MKD39_RS11670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKD39_RS11680	COG0037	tRNA processing
MKD39_RS11685	COG1098	S1 RNA binding domain
MKD39_RS11695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKD39_RS11700	COG3956	TIGRFAM MazG family protein
MKD39_RS11705	COG2244	polysaccharide biosynthetic process
MKD39_RS11710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKD39_RS11715	COG0193	aminoacyl-tRNA hydrolase activity
MKD39_RS11720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MKD39_RS11725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKD39_RS11730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MKD39_RS11735	COG2088	sporulation resulting in formation of a cellular spore
MKD39_RS11740	COG0251	oxidation-reduction process
MKD39_RS11745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKD39_RS11750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MKD39_RS11755	COG4466	Protein conserved in bacteria
MKD39_RS11760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MKD39_RS11765	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MKD39_RS11770	COG0084	hydrolase, TatD family'
MKD39_RS11775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKD39_RS11775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKD39_RS11780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKD39_RS11785	COG2827	Endonuclease containing a URI domain
MKD39_RS11790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MKD39_RS11795	COG4467	Involved in initiation control of chromosome replication
MKD39_RS11800	COG1774	PSP1 C-terminal conserved region
MKD39_RS11805	COG0470	DNA polymerase III
MKD39_RS11810	COG3870	Protein conserved in bacteria
MKD39_RS11815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MKD39_RS11820	COG1982	Orn Lys Arg decarboxylase major
MKD39_RS11845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKD39_RS11855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKD39_RS11870	COG2188	Transcriptional regulator
MKD39_RS11875	COG0366	Alpha amylase catalytic
MKD39_RS11880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKD39_RS11880	COG1263	PTS System
MKD39_RS11890	COG0493	'glutamate synthase
MKD39_RS11895	COG0067	glutamate synthase
MKD39_RS11895	COG0070	glutamate synthase
MKD39_RS11895	COG0069	glutamate synthase activity
MKD39_RS11900	COG0583	DNA-binding transcription factor activity
MKD39_RS11930	COG1388	LysM domain
MKD39_RS11930	COG3942	CHAP domain
MKD39_RS11935	COG0626	cystathionine gamma-synthase activity
MKD39_RS11940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKD39_RS11955	COG0733	neurotransmitter:sodium symporter activity
MKD39_RS11970	COG1647	Serine aminopeptidase, S33
MKD39_RS11980	COG0671	phosphoesterase, PA-phosphatase related
MKD39_RS11990	COG5609	conserved protein (DUF2294)
MKD39_RS11995	COG3002	Belongs to the UPF0753 family
MKD39_RS12000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKD39_RS12005	COG3759	membrane
MKD39_RS12020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKD39_RS12030	COG5484	DNA packaging
MKD39_RS12030	COG3728	DNA packaging
MKD39_RS12065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MKD39_RS12065	COG0519	Catalyzes the synthesis of GMP from XMP
MKD39_RS12070	COG0516	GMP reductase activity
MKD39_RS12070	COG0517	IMP dehydrogenase activity
MKD39_RS12075	COG2233	PERMEase
MKD39_RS12080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKD39_RS12100	COG1823	symporter activity
MKD39_RS12105	COG0778	Nitroreductase
MKD39_RS12115	COG0450	alkyl hydroperoxide reductase
MKD39_RS12120	COG3634	alkyl hydroperoxide reductase activity
MKD39_RS12130	COG0406	alpha-ribazole phosphatase activity
MKD39_RS12135	COG1280	lysine exporter protein (LysE YggA)
MKD39_RS12200	COG3682	Transcriptional regulator
MKD39_RS12210	COG1012	belongs to the aldehyde dehydrogenase family
MKD39_RS12220	COG1902	pentaerythritol trinitrate reductase activity
MKD39_RS12275	COG0456	acetyltransferase
MKD39_RS12285	COG2378	regulation of single-species biofilm formation
MKD39_RS12305	COG1131	(ABC) transporter
MKD39_RS12360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MKD39_RS12370	COG0360	Binds together with S18 to 16S ribosomal RNA
MKD39_RS12385	COG0012	GTP binding
MKD39_RS12390	COG4481	Protein conserved in bacteria
MKD39_RS12395	COG0668	transmembrane transport
MKD39_RS12400	COG1475	DNA binding
MKD39_RS12405	COG0626	cystathionine gamma-synthase activity
MKD39_RS12410	COG0626	cystathionine gamma-synthase activity
MKD39_RS12415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKD39_RS12415	COG0646	methionine synthase
MKD39_RS12420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MKD39_RS12435	COG0488	(ABC) transporter
MKD39_RS12445	COG0346	lactoylglutathione lyase activity
MKD39_RS12450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKD39_RS12475	COG1136	(ABC) transporter
MKD39_RS12480	COG0577	efflux transmembrane transporter activity
MKD39_RS12520	COG0357	Ribosomal RNA small subunit methyltransferase G
MKD39_RS12525	COG0445	tRNA wobble uridine modification
MKD39_RS12530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MKD39_RS12535	COG0594	ribonuclease P activity
MKD39_RS12545	COG1230	cation diffusion facilitator family transporter
MKD39_RS12555	COG1937	Protein conserved in bacteria
MKD39_RS12560	COG2217	Heavy metal translocating P-type atpase
MKD39_RS12640	COG3226	Transcriptional regulator