locus-tag	class	description
IOD51_RS00005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD51_RS00025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IOD51_RS00035	COG1413	lyase activity
IOD51_RS00040	COG1413	lyase activity
IOD51_RS00050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IOD51_RS00070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD51_RS00075	COG2190	(PTS) system
IOD51_RS00080	COG4479	Belongs to the UPF0346 family
IOD51_RS00085	COG0793	Belongs to the peptidase S41A family
IOD51_RS00095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD51_RS00100	COG0671	phosphoesterase, PA-phosphatase related
IOD51_RS00105	COG0745	RESPONSE REGULATOR receiver
IOD51_RS00110	COG5002	protein histidine kinase activity
IOD51_RS00115	COG0567	Dehydrogenase, E1 component
IOD51_RS00135	COG0714	Associated with various cellular activities
IOD51_RS00140	COG4548	von Willebrand factor, type A
IOD51_RS00145	COG1114	Component of the transport system for branched-chain amino acids
IOD51_RS00150	COG3853	Toxic anion resistance protein (TelA)
IOD51_RS00160	COG1254	Belongs to the acylphosphatase family
IOD51_RS00170	COG1278	Cold shock
IOD51_RS00185	COG1131	(ABC) transporter
IOD51_RS00210	COG1473	amidohydrolase
IOD51_RS00215	COG2171	N-acyltransferase activity
IOD51_RS00220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD51_RS00225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD51_RS00230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD51_RS00235	COG0527	aspartate kinase activity
IOD51_RS00240	COG0488	(ABC) transporter
IOD51_RS00245	COG2996	Protein conserved in bacteria
IOD51_RS00250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOD51_RS00255	COG0573	inorganic phosphate transmembrane transporter activity
IOD51_RS00260	COG0581	inorganic phosphate transmembrane transporter activity
IOD51_RS00265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD51_RS00270	COG0704	Plays a role in the regulation of phosphate uptake
IOD51_RS00285	COG4607	ABC-type enterochelin transport system periplasmic component
IOD51_RS00290	COG0561	phosphatase activity
IOD51_RS00295	COG2348	transferase activity, transferring amino-acyl groups
IOD51_RS00300	COG2348	transferase activity, transferring amino-acyl groups
IOD51_RS00305	COG0159	tryptophan synthase activity
IOD51_RS00315	COG0135	phosphoribosylanthranilate isomerase activity
IOD51_RS00320	COG0134	indole-3-glycerol-phosphate synthase activity
IOD51_RS00325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD51_RS00330	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD51_RS00335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD51_RS00340	COG1363	Peptidase, m42
IOD51_RS00345	COG0287	Prephenate dehydrogenase
IOD51_RS00350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD51_RS00355	COG1942	4-Oxalocrotonate Tautomerase
IOD51_RS00375	COG0392	lysyltransferase activity
IOD51_RS00375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IOD51_RS00380	COG0628	permease
IOD51_RS00385	COG3711	transcriptional antiterminator
IOD51_RS00390	COG1115	amino acid carrier protein
IOD51_RS00395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD51_RS00400	COG0187	DNA topoisomerase II activity
IOD51_RS00405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IOD51_RS00410	COG4841	protein insertion into membrane
IOD51_RS00415	COG0824	Thioesterase
IOD51_RS00420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD51_RS00425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD51_RS00430	COG1970	mechanosensitive ion channel activity
IOD51_RS00435	COG0419	ATPase involved in DNA repair
IOD51_RS00440	COG0420	3'-5' exonuclease activity
IOD51_RS00445	COG4846	Membrane protein involved in cytochrome C biogenesis
IOD51_RS00460	COG4224	UPF0291 protein
IOD51_RS00470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD51_RS00475	COG2340	Cysteine-rich secretory protein family
IOD51_RS00480	COG0516	GMP reductase activity
IOD51_RS00485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD51_RS00495	COG0753	catalase activity
IOD51_RS00500	COG0833	amino acid
IOD51_RS00515	COG0083	homoserine kinase activity
IOD51_RS00520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD51_RS00525	COG0460	homoserine dehydrogenase
IOD51_RS00530	COG0527	aspartate kinase activity
IOD51_RS00545	COG1525	nuclease
IOD51_RS00560	COG2197	response regulator
IOD51_RS00565	COG4585	Histidine kinase
IOD51_RS00580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD51_RS00620	COG0789	Transcriptional regulator
IOD51_RS00625	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IOD51_RS00630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD51_RS00635	COG0386	Belongs to the glutathione peroxidase family
IOD51_RS00640	COG1923	regulation of RNA biosynthetic process
IOD51_RS00645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IOD51_RS00655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD51_RS00660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD51_RS00665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD51_RS00675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IOD51_RS00680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IOD51_RS00690	COG4550	Control of competence regulator ComK, YlbF/YmcA
IOD51_RS00695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD51_RS00705	COG4195	phage-related replication protein
IOD51_RS00710	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD51_RS00715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD51_RS00715	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD51_RS00720	COG1692	metallophosphoesterase
IOD51_RS00730	COG1418	mRNA catabolic process
IOD51_RS00735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOD51_RS00740	COG1058	Belongs to the CinA family
IOD51_RS00740	COG1546	Belongs to the CinA family
IOD51_RS00760	COG0300	oxidoreductase activity
IOD51_RS00765	COG0612	Peptidase, M16
IOD51_RS00770	COG0612	Peptidase, M16
IOD51_RS00775	COG2188	Transcriptional regulator
IOD51_RS00780	COG1674	ftsk spoiiie
IOD51_RS00785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOD51_RS00790	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD51_RS00795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOD51_RS00800	COG0196	riboflavin kinase activity
IOD51_RS00805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD51_RS00810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD51_RS00820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOD51_RS00825	COG1358	cellular component organization or biogenesis
IOD51_RS00830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IOD51_RS00835	COG0195	Participates in both transcription termination and antitermination
IOD51_RS00840	COG0779	Required for maturation of 30S ribosomal subunits
IOD51_RS00845	COG2176	DNA-directed DNA polymerase activity
IOD51_RS00850	COG0442	prolyl-tRNA aminoacylation
IOD51_RS00860	COG4589	Belongs to the CDS family
IOD51_RS00865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD51_RS00870	COG0233	cytoplasmic translational termination
IOD51_RS00875	COG0528	UMP kinase activity
IOD51_RS00880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOD51_RS00885	COG0052	Belongs to the universal ribosomal protein uS2 family
IOD51_RS00890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IOD51_RS00895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IOD51_RS00900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IOD51_RS00905	COG4974	Belongs to the 'phage' integrase family
IOD51_RS00910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IOD51_RS00915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD51_RS00920	COG0758	DNA mediated transformation
IOD51_RS00930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOD51_RS00935	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD51_RS00940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD51_RS00950	COG4485	Bacterial membrane protein, YfhO
IOD51_RS00960	COG0335	large ribosomal subunit rRNA binding
IOD51_RS00965	COG0336	Belongs to the RNA methyltransferase TrmD family
IOD51_RS00970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOD51_RS00975	COG0228	four-way junction DNA binding
IOD51_RS00980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD51_RS00985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IOD51_RS00990	COG0552	protein localization to endoplasmic reticulum
IOD51_RS00995	COG1196	nuclear chromosome segregation
IOD51_RS01000	COG0571	ribonuclease III activity
IOD51_RS01005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD51_RS01020	COG0416	fatty acid biosynthetic process
IOD51_RS01025	COG1349	DNA-binding transcription factor activity
IOD51_RS01045	COG1461	Dihydroxyacetone kinase
IOD51_RS01050	COG1302	Protein conserved in bacteria
IOD51_RS01055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD51_RS01065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD51_RS01070	COG1162	GTPase activity
IOD51_RS01080	COG0631	protein serine/threonine phosphatase activity
IOD51_RS01085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOD51_RS01090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IOD51_RS01090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD51_RS01100	COG0242	peptide deformylase activity
IOD51_RS01105	COG2314	TM2 domain
IOD51_RS01110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD51_RS01115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD51_RS01120	COG1758	RNA polymerase activity
IOD51_RS01125	COG0194	GDP metabolic process
IOD51_RS01145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IOD51_RS01150	COG0284	orotidine-5'-phosphate decarboxylase activity
IOD51_RS01155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOD51_RS01160	COG0505	Belongs to the CarA family
IOD51_RS01170	COG0540	Belongs to the ATCase OTCase family
IOD51_RS01175	COG2233	PERMEase
IOD51_RS01180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IOD51_RS01185	COG0564	pseudouridine synthase activity
IOD51_RS01190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IOD51_RS01195	COG1388	LysM domain
IOD51_RS01195	COG3942	CHAP domain
IOD51_RS01205	COG0702	epimerase
IOD51_RS01210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD51_RS01215	COG3599	regulation of cell shape
IOD51_RS01225	COG0762	integral membrane protein
IOD51_RS01230	COG1799	cell septum assembly
IOD51_RS01235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD51_RS01240	COG1496	oxidoreductase activity
IOD51_RS01245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD51_RS01250	COG0849	cell division
IOD51_RS01255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOD51_RS01260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD51_RS01265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD51_RS01270	COG0768	penicillin binding
IOD51_RS01275	COG4839	cell division protein FtsL
IOD51_RS01280	COG0275	rRNA processing
IOD51_RS01285	COG2001	Belongs to the MraZ family
IOD51_RS01290	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IOD51_RS01295	COG0454	-acetyltransferase
IOD51_RS01330	COG1388	LysM domain
IOD51_RS01330	COG5632	N-Acetylmuramoyl-L-alanine amidase
IOD51_RS01375	COG5280	Phage tail tape measure protein TP901
IOD51_RS01375	COG3953	SLT domain
IOD51_RS01490	COG0756	dUTP diphosphatase activity
IOD51_RS01560	COG0305	Participates in initiation and elongation during chromosome replication
IOD51_RS01580	COG0629	single-stranded DNA binding
IOD51_RS01630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD51_RS01655	COG0582	viral genome integration into host DNA
IOD51_RS01665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOD51_RS01670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOD51_RS01675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD51_RS01680	COG1053	succinate dehydrogenase
IOD51_RS01685	COG2009	succinate dehydrogenase
IOD51_RS01690	COG0322	excinuclease ABC activity
IOD51_RS01695	COG3118	belongs to the thioredoxin family
IOD51_RS01700	COG1193	negative regulation of DNA recombination
IOD51_RS01705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IOD51_RS01705	COG1796	DNA polymerase
IOD51_RS01715	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IOD51_RS01720	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD51_RS01725	COG0072	phenylalanine-tRNA ligase activity
IOD51_RS01725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD51_RS01730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOD51_RS01735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD51_RS01740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOD51_RS01750	COG1323	Belongs to the UPF0348 family
IOD51_RS01755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOD51_RS01760	COG0742	ribosomal rna small subunit methyltransferase
IOD51_RS01770	COG4471	UPF0298 protein
IOD51_RS01775	COG0584	glycerophosphoryl diester phosphodiesterase
IOD51_RS01780	COG3679	Belongs to the UPF0342 family
IOD51_RS01795	COG0109	protoheme IX farnesyltransferase activity
IOD51_RS01800	COG1612	heme a metabolic process
IOD51_RS01810	COG0772	Belongs to the SEDS family
IOD51_RS01815	COG4838	Belongs to the UPF0358 family
IOD51_RS01820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD51_RS01825	COG4896	Protein conserved in bacteria
IOD51_RS01830	COG1217	gtp-binding protein TYPA
IOD51_RS01840	COG0483	inositol monophosphate 1-phosphatase activity
IOD51_RS01845	COG4493	Belongs to the UPF0637 family
IOD51_RS01850	COG1914	H( )-stimulated, divalent metal cation uptake system
IOD51_RS01870	COG1177	transmembrane transport
IOD51_RS01875	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD51_RS01880	COG3842	ATPase activity
IOD51_RS01890	COG4476	Belongs to the UPF0223 family
IOD51_RS01905	COG0022	dehydrogenase e1 component
IOD51_RS01920	COG0242	peptide deformylase activity
IOD51_RS01925	COG5503	Protein of unknown function (DUF1447)
IOD51_RS01930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOD51_RS01940	COG2832	Protein of unknown function (DUF454)
IOD51_RS01945	COG0569	domain protein
IOD51_RS01950	COG1294	oxidase, subunit
IOD51_RS01955	COG1271	oxidase subunit
IOD51_RS01965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD51_RS01980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IOD51_RS02000	COG4172	Belongs to the ABC transporter superfamily
IOD51_RS02005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IOD51_RS02010	COG0151	Belongs to the GarS family
IOD51_RS02015	COG0138	bifunctional purine biosynthesis protein purh
IOD51_RS02025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOD51_RS02035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD51_RS02040	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD51_RS02045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD51_RS02050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD51_RS02055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD51_RS02060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOD51_RS02065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD51_RS02070	COG1017	nitric oxide dioxygenase activity
IOD51_RS02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD51_RS02080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOD51_RS02085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD51_RS02090	COG1845	cytochrome c oxidase, subunit III
IOD51_RS02095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOD51_RS02105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD51_RS02110	COG1316	TRANSCRIPTIONal
IOD51_RS02140	COG3594	Acyltransferase
IOD51_RS02145	COG0436	Aminotransferase
IOD51_RS02150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IOD51_RS02160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IOD51_RS02165	COG1169	isochorismate synthase
IOD51_RS02170	COG1575	Belongs to the MenA family. Type 1 subfamily
IOD51_RS02210	COG4873	Protein conserved in bacteria
IOD51_RS02225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOD51_RS02235	COG0861	Integral membrane protein TerC family
IOD51_RS02240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOD51_RS02250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD51_RS02255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD51_RS02260	COG2814	Major facilitator Superfamily
IOD51_RS02265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IOD51_RS02270	COG2382	esterase
IOD51_RS02275	COG0628	permease
IOD51_RS02285	COG0569	domain protein
IOD51_RS02285	COG0475	glutathione-regulated potassium exporter activity
IOD51_RS02290	COG2239	Acts as a magnesium transporter
IOD51_RS02295	COG0564	pseudouridine synthase activity
IOD51_RS02300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD51_RS02305	COG2357	RelA SpoT domain protein
IOD51_RS02315	COG4116	CYTH
IOD51_RS02320	COG2346	COG2346, Truncated hemoglobins
IOD51_RS02325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD51_RS02340	COG1164	Oligoendopeptidase f
IOD51_RS02350	COG4862	establishment of competence for transformation
IOD51_RS02355	COG1393	Belongs to the ArsC family
IOD51_RS02360	COG0180	Tryptophanyl-tRNA synthetase
IOD51_RS02365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD51_RS02370	COG0601	transmembrane transport
IOD51_RS02375	COG4608	Belongs to the ABC transporter superfamily
IOD51_RS02380	COG0444	Belongs to the ABC transporter superfamily
IOD51_RS02385	COG0747	negative chemotaxis
IOD51_RS02390	COG4166	transmembrane transport
IOD51_RS02395	COG4608	Belongs to the ABC transporter superfamily
IOD51_RS02400	COG0444	Belongs to the ABC transporter superfamily
IOD51_RS02405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD51_RS02410	COG0601	transmembrane transport
IOD51_RS02425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD51_RS02440	COG0542	response to heat
IOD51_RS02455	COG0561	phosphatase activity
IOD51_RS02460	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD51_RS02470	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD51_RS02475	COG1074	ATP-dependent DNA helicase activity
IOD51_RS02480	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IOD51_RS02495	COG0398	Pfam SNARE associated Golgi protein
IOD51_RS02500	COG0166	Belongs to the GPI family
IOD51_RS02505	COG0137	argininosuccinate synthase activity
IOD51_RS02510	COG0165	Argininosuccinate lyase
IOD51_RS02515	COG0584	glycerophosphoryl diester phosphodiesterase
IOD51_RS02560	COG1902	pentaerythritol trinitrate reductase activity
IOD51_RS02565	COG1098	S1 RNA binding domain
IOD51_RS02570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD51_RS02580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD51_RS02580	COG2111	Na H antiporter
IOD51_RS02585	COG2111	Na H antiporter
IOD51_RS02590	COG1006	Multisubunit Na H antiporter MnhC subunit
IOD51_RS02595	COG0651	ATP synthesis coupled electron transport
IOD51_RS02600	COG1863	multisubunit Na H antiporter MnhE subunit
IOD51_RS02605	COG2212	antiporter activity
IOD51_RS02610	COG1320	monovalent cation:proton antiporter activity
IOD51_RS02620	COG2050	protein possibly involved in aromatic compounds catabolism
IOD51_RS02625	COG2056	Na+-H+ antiporter family
IOD51_RS02630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD51_RS02635	COG1252	NADH dehydrogenase
IOD51_RS02640	COG0316	Belongs to the HesB IscA family
IOD51_RS02645	COG4844	belongs to the
IOD51_RS02650	COG1252	NADH dehydrogenase
IOD51_RS02655	COG4837	Protein of unknown function (DUF1462)
IOD51_RS02660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IOD51_RS02665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IOD51_RS02670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD51_RS02675	COG1696	Membrane protein involved in D-alanine export
IOD51_RS02680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD51_RS02690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD51_RS02695	COG0647	UMP catabolic process
IOD51_RS02700	COG2445	Protein of unknown function DUF86
IOD51_RS02710	COG4470	Protein conserved in bacteria
IOD51_RS02715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD51_RS02720	COG0737	Belongs to the 5'-nucleotidase family
IOD51_RS02725	COG0730	response to heat
IOD51_RS02730	COG1801	Protein of unknown function DUF72
IOD51_RS02735	COG2070	2-Nitropropane dioxygenase
IOD51_RS02740	COG0719	Fe-S assembly protein
IOD51_RS02745	COG0822	iron-sulfur transferase activity
IOD51_RS02750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD51_RS02755	COG0719	Fe-S assembly protein
IOD51_RS02760	COG0396	ATPase activity
IOD51_RS02780	COG1518	maintenance of DNA repeat elements
IOD51_RS02790	COG3237	CsbD-like
IOD51_RS02800	COG1464	Belongs to the NlpA lipoprotein family
IOD51_RS02805	COG2011	ABC-type metal ion transport system permease component
IOD51_RS02810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD51_RS02820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IOD51_RS02825	COG0509	glycine decarboxylation via glycine cleavage system
IOD51_RS02830	COG1393	Belongs to the ArsC family
IOD51_RS02835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD51_RS02845	COG0710	3-dehydroquinate dehydratase activity
IOD51_RS02850	COG1764	response to oxidative stress
IOD51_RS02860	COG1279	arginine transmembrane transporter activity
IOD51_RS02865	COG0406	alpha-ribazole phosphatase activity
IOD51_RS02905	COG0456	acetyltransferase
IOD51_RS02910	COG4195	phage-related replication protein
IOD51_RS02940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD51_RS02955	COG3728	DNA packaging
IOD51_RS02955	COG5484	DNA packaging
IOD51_RS03040	COG0582	viral genome integration into host DNA
IOD51_RS03055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOD51_RS03060	COG0557	exoribonuclease II activity
IOD51_RS03065	COG1647	Serine aminopeptidase, S33
IOD51_RS03070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD51_RS03080	COG0148	phosphopyruvate hydratase activity
IOD51_RS03085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOD51_RS03090	COG0149	triose-phosphate isomerase activity
IOD51_RS03095	COG0126	phosphoglycerate kinase activity
IOD51_RS03105	COG2390	Transcriptional regulator
IOD51_RS03125	COG1090	epimerase
IOD51_RS03130	COG0740	serine-type endopeptidase activity
IOD51_RS03135	COG1481	regulation of sporulation
IOD51_RS03140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IOD51_RS03145	COG1660	Displays ATPase and GTPase activities
IOD51_RS03150	COG0492	ferredoxin-NADP+ reductase activity
IOD51_RS03165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IOD51_RS03170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IOD51_RS03175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD51_RS03180	COG0556	nucleotide-excision repair
IOD51_RS03200	COG3942	CHAP domain
IOD51_RS03200	COG1388	LysM domain
IOD51_RS03210	COG0653	protein targeting
IOD51_RS03215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD51_RS03220	COG1040	competence protein
IOD51_RS03225	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IOD51_RS03235	COG1739	Uncharacterized protein family UPF0029
IOD51_RS03240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD51_RS03245	COG2199	diguanylate cyclase activity
IOD51_RS03260	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD51_RS03265	COG1929	Belongs to the glycerate kinase type-1 family
IOD51_RS03285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD51_RS03305	COG4604	ABC transporter, ATP-binding protein
IOD51_RS03310	COG4605	iron ion homeostasis
IOD51_RS03315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS03320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD51_RS03325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD51_RS03330	COG1780	Probably involved in ribonucleotide reductase function
IOD51_RS03340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOD51_RS03345	COG3104	oligopeptide transport
IOD51_RS03350	COG1597	lipid kinase activity
IOD51_RS03360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD51_RS03365	COG3104	oligopeptide transport
IOD51_RS03370	COG1174	glycine betaine transport
IOD51_RS03375	COG0517	IMP dehydrogenase activity
IOD51_RS03375	COG1125	glycine betaine transport
IOD51_RS03380	COG0514	ATP-dependent DNA helicase (RecQ)
IOD51_RS03385	COG0488	(ABC) transporter
IOD51_RS03395	COG1368	sulfuric ester hydrolase activity
IOD51_RS03400	COG1984	allophanate hydrolase subunit 2
IOD51_RS03425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD51_RS03425	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD51_RS03430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IOD51_RS03435	COG0720	synthase
IOD51_RS03440	COG0602	queuosine metabolic process
IOD51_RS03450	COG0463	Glycosyl transferase, family 2
IOD51_RS03455	COG0656	L-ascorbic acid biosynthetic process
IOD51_RS03460	COG1253	flavin adenine dinucleotide binding
IOD51_RS03465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD51_RS03465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD51_RS03465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD51_RS03470	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD51_RS03475	COG1349	DNA-binding transcription factor activity
IOD51_RS03480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD51_RS03510	COG0415	Belongs to the DNA photolyase family
IOD51_RS03515	COG0471	metal ion transport
IOD51_RS03525	COG0523	cobalamin synthesis protein
IOD51_RS03535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IOD51_RS03540	COG4988	ABC transporter
IOD51_RS03545	COG1968	undecaprenyl-diphosphatase activity
IOD51_RS03555	COG1671	Belongs to the UPF0178 family
IOD51_RS03560	COG1611	Belongs to the LOG family
IOD51_RS03565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD51_RS03590	COG2839	Protein conserved in bacteria
IOD51_RS03600	COG0583	DNA-binding transcription factor activity
IOD51_RS03610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD51_RS03620	COG0217	transcriptional regulatory protein
IOD51_RS03640	COG3942	CHAP domain
IOD51_RS03640	COG1388	LysM domain
IOD51_RS03645	COG0306	phosphate transporter
IOD51_RS03650	COG1392	Phosphate transport regulator
IOD51_RS03655	COG0577	efflux transmembrane transporter activity
IOD51_RS03660	COG1136	(ABC) transporter
IOD51_RS03665	COG2205	protein histidine kinase activity
IOD51_RS03670	COG0745	RESPONSE REGULATOR receiver
IOD51_RS03675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD51_RS03685	COG0657	acetylesterase activity
IOD51_RS03690	COG3949	Membrane
IOD51_RS03700	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IOD51_RS03710	COG2376	Dihydroxyacetone kinase
IOD51_RS03715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS03725	COG1120	ATPase activity
IOD51_RS03730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IOD51_RS03735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD51_RS03740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IOD51_RS03740	COG0463	Glycosyl transferase, family 2
IOD51_RS03745	COG0438	transferase activity, transferring glycosyl groups
IOD51_RS03750	COG1132	(ABC) transporter
IOD51_RS03755	COG1686	Belongs to the peptidase S11 family
IOD51_RS03765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD51_RS03775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IOD51_RS03780	COG1682	transport, permease protein
IOD51_RS03785	COG1134	teichoic acid transport
IOD51_RS03790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IOD51_RS03800	COG1321	iron dependent repressor
IOD51_RS03825	COG1320	monovalent cation:proton antiporter activity
IOD51_RS03830	COG2212	antiporter activity
IOD51_RS03835	COG1863	multisubunit Na H antiporter MnhE subunit
IOD51_RS03840	COG0651	ATP synthesis coupled electron transport
IOD51_RS03845	COG1006	Multisubunit Na H antiporter MnhC subunit
IOD51_RS03850	COG2111	Na H antiporter
IOD51_RS03855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD51_RS03855	COG2111	Na H antiporter
IOD51_RS03860	COG4974	Belongs to the 'phage' integrase family
IOD51_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS03925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD51_RS03940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD51_RS03945	COG0018	arginyl-trna synthetase
IOD51_RS04030	COG3875	lactate racemase activity
IOD51_RS04035	COG1606	tRNA processing
IOD51_RS04040	COG1691	(AIR) carboxylase
IOD51_RS04045	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IOD51_RS04060	COG1078	dGTPase activity
IOD51_RS04070	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOD51_RS04075	COG0667	Aldo Keto reductase
IOD51_RS04085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD51_RS04090	COG1278	Cold shock
IOD51_RS04095	COG4844	belongs to the
IOD51_RS04115	COG0095	Lipoate-protein ligase
IOD51_RS04125	COG3253	May function as heme-dependent peroxidase
IOD51_RS04130	COG2966	Psort location CytoplasmicMembrane, score
IOD51_RS04145	COG2363	Small membrane protein
IOD51_RS04155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD51_RS04170	COG0477	Major facilitator Superfamily
IOD51_RS04185	COG0183	Belongs to the thiolase family
IOD51_RS04190	COG0318	PFAM AMP-dependent synthetase and ligase
IOD51_RS04200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD51_RS04205	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IOD51_RS04215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD51_RS04220	COG1469	GTP cyclohydrolase I activity
IOD51_RS04225	COG2271	Major facilitator Superfamily
IOD51_RS04265	COG0431	NADPH-dependent FMN reductase
IOD51_RS04270	COG0561	phosphatase activity
IOD51_RS04280	COG1428	Deoxynucleoside kinase
IOD51_RS04285	COG1428	Deoxynucleoside kinase
IOD51_RS04290	COG0546	phosphoglycolate phosphatase activity
IOD51_RS04305	COG3177	Filamentation induced by cAMP protein fic
IOD51_RS04320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD51_RS04325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD51_RS04330	COG0737	Belongs to the 5'-nucleotidase family
IOD51_RS04355	COG1473	amidohydrolase
IOD51_RS04360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD51_RS04365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD51_RS04375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD51_RS04385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IOD51_RS04390	COG0085	RNA polymerase activity
IOD51_RS04395	COG2813	Specifically methylates the guanine in position
IOD51_RS04400	COG0222	ribosome binding
IOD51_RS04405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IOD51_RS04410	COG0081	regulation of translation
IOD51_RS04415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOD51_RS04420	COG0250	Participates in transcription elongation, termination and antitermination
IOD51_RS04425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD51_RS04430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD51_RS04440	COG3688	RNA-binding protein containing a PIN domain
IOD51_RS04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD51_RS04450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IOD51_RS04455	COG0215	cysteine-tRNA ligase activity
IOD51_RS04460	COG1045	serine acetyltransferase
IOD51_RS04465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD51_RS04470	COG4956	integral membrane protein (PIN domain superfamily)
IOD51_RS04475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD51_RS04480	COG0542	response to heat
IOD51_RS04485	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IOD51_RS04490	COG3880	PFAM UvrB UvrC protein
IOD51_RS04495	COG4463	regulation of RNA biosynthetic process
IOD51_RS04500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD51_RS04505	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IOD51_RS04510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IOD51_RS04515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD51_RS04520	COG2259	Doxx family
IOD51_RS04625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD51_RS04630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD51_RS04645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD51_RS04650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IOD51_RS04655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD51_RS04670	COG1098	S1 RNA binding domain
IOD51_RS04680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD51_RS04685	COG3956	TIGRFAM MazG family protein
IOD51_RS04690	COG2244	polysaccharide biosynthetic process
IOD51_RS04695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD51_RS04700	COG0193	aminoacyl-tRNA hydrolase activity
IOD51_RS04705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IOD51_RS04710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD51_RS04715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD51_RS04720	COG2088	sporulation resulting in formation of a cellular spore
IOD51_RS04730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD51_RS04735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IOD51_RS04740	COG4466	Protein conserved in bacteria
IOD51_RS04745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD51_RS04750	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IOD51_RS04755	COG0084	hydrolase, TatD family'
IOD51_RS04760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD51_RS04760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD51_RS04765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IOD51_RS04770	COG2827	Endonuclease containing a URI domain
IOD51_RS04775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IOD51_RS04780	COG4467	Involved in initiation control of chromosome replication
IOD51_RS04785	COG1774	PSP1 C-terminal conserved region
IOD51_RS04790	COG0470	DNA polymerase III
IOD51_RS04795	COG3870	Protein conserved in bacteria
IOD51_RS04800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOD51_RS04805	COG1982	Orn Lys Arg decarboxylase major
IOD51_RS04810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD51_RS04830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD51_RS04840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOD51_RS04855	COG2188	Transcriptional regulator
IOD51_RS04860	COG0366	Alpha amylase catalytic
IOD51_RS04865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD51_RS04865	COG1263	PTS System
IOD51_RS04875	COG0493	'glutamate synthase
IOD51_RS04880	COG0069	glutamate synthase activity
IOD51_RS04880	COG0070	glutamate synthase
IOD51_RS04880	COG0067	glutamate synthase
IOD51_RS04885	COG0583	DNA-binding transcription factor activity
IOD51_RS04905	COG0494	nUDIX hydrolase
IOD51_RS04915	COG3942	CHAP domain
IOD51_RS04915	COG1388	LysM domain
IOD51_RS04920	COG0626	cystathionine gamma-synthase activity
IOD51_RS04925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD51_RS04940	COG0733	neurotransmitter:sodium symporter activity
IOD51_RS04950	COG1647	Serine aminopeptidase, S33
IOD51_RS04970	COG5609	conserved protein (DUF2294)
IOD51_RS04975	COG3002	Belongs to the UPF0753 family
IOD51_RS04980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD51_RS05000	COG0519	Catalyzes the synthesis of GMP from XMP
IOD51_RS05000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD51_RS05005	COG0516	GMP reductase activity
IOD51_RS05005	COG0517	IMP dehydrogenase activity
IOD51_RS05010	COG2233	PERMEase
IOD51_RS05015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD51_RS05035	COG1823	symporter activity
IOD51_RS05040	COG0778	Nitroreductase
IOD51_RS05050	COG0450	alkyl hydroperoxide reductase
IOD51_RS05055	COG3634	alkyl hydroperoxide reductase activity
IOD51_RS05070	COG0406	alpha-ribazole phosphatase activity
IOD51_RS05075	COG1280	lysine exporter protein (LysE YggA)
IOD51_RS05100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD51_RS05110	COG0360	Binds together with S18 to 16S ribosomal RNA
IOD51_RS05125	COG0012	GTP binding
IOD51_RS05130	COG4481	Protein conserved in bacteria
IOD51_RS05135	COG0668	transmembrane transport
IOD51_RS05140	COG1475	DNA binding
IOD51_RS05145	COG0626	cystathionine gamma-synthase activity
IOD51_RS05150	COG0626	cystathionine gamma-synthase activity
IOD51_RS05155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IOD51_RS05155	COG0646	methionine synthase
IOD51_RS05160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD51_RS05180	COG0346	lactoylglutathione lyase activity
IOD51_RS05185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD51_RS05200	COG2826	transposase and inactivated derivatives, IS30 family
IOD51_RS05215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD51_RS05215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD51_RS05240	COG1349	DNA-binding transcription factor activity
IOD51_RS05245	COG4175	Glycine betaine
IOD51_RS05245	COG3448	diguanylate cyclase activity
IOD51_RS05290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IOD51_RS05410	COG3682	Transcriptional regulator
IOD51_RS05455	COG0456	acetyltransferase
IOD51_RS05490	COG3328	transposase activity
IOD51_RS05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD51_RS05525	COG0551	DNA topoisomerase type I activity
IOD51_RS05560	COG0488	(ABC) transporter
IOD51_RS05585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD51_RS05595	COG2226	methyltransferase
IOD51_RS05635	COG0583	DNA-binding transcription factor activity
IOD51_RS05640	COG2855	membrane
IOD51_RS05645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD51_RS05675	COG1136	(ABC) transporter
IOD51_RS05680	COG0577	efflux transmembrane transporter activity
IOD51_RS05715	COG0357	Ribosomal RNA small subunit methyltransferase G
IOD51_RS05720	COG0445	tRNA wobble uridine modification
IOD51_RS05725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IOD51_RS05730	COG0594	ribonuclease P activity
IOD51_RS05740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD51_RS05745	COG0592	DNA-directed DNA polymerase activity
IOD51_RS05750	COG2501	S4 domain
IOD51_RS05755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD51_RS05760	COG0187	DNA topoisomerase II activity
IOD51_RS05770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOD51_RS05775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOD51_RS05780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD51_RS05790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD51_RS05800	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IOD51_RS05805	COG0359	binds to the 23S rRNA
IOD51_RS05810	COG0305	Participates in initiation and elongation during chromosome replication
IOD51_RS05815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD51_RS05830	COG0745	RESPONSE REGULATOR receiver
IOD51_RS05835	COG5002	protein histidine kinase activity
IOD51_RS05840	COG4863	YycH protein
IOD51_RS05850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IOD51_RS05855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IOD51_RS05945	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD51_RS05960	COG0584	glycerophosphoryl diester phosphodiesterase
IOD51_RS05965	COG2030	dehydratase
IOD51_RS06015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IOD51_RS06055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD51_RS06065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IOD51_RS06085	COG0542	response to heat
IOD51_RS06095	COG1002	Type II restriction enzyme, methylase subunits
IOD51_RS06150	COG0640	Transcriptional regulator
IOD51_RS06155	COG2217	Heavy metal translocating P-type atpase
IOD51_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD51_RS06165	COG2210	Belongs to the sulfur carrier protein TusA family
IOD51_RS06170	COG1937	Protein conserved in bacteria
IOD51_RS06175	COG0730	response to heat
IOD51_RS06185	COG1388	LysM domain
IOD51_RS06270	COG3764	Sortase (surface protein transpeptidase)
IOD51_RS06295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD51_RS06360	COG0789	Transcriptional regulator
IOD51_RS06370	COG0702	epimerase
IOD51_RS06375	COG2130	NADP-dependent
IOD51_RS06390	COG0640	Transcriptional regulator
IOD51_RS06395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD51_RS06410	COG2217	Heavy metal translocating P-type atpase
IOD51_RS06415	COG1388	LysM domain
IOD51_RS06420	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD51_RS06430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD51_RS06475	COG1511	domain protein
IOD51_RS06490	COG1309	transcriptional regulator
IOD51_RS06520	COG0561	phosphatase activity
IOD51_RS06525	COG1401	restriction endodeoxyribonuclease activity
IOD51_RS06530	COG4268	DNA restriction-modification system
IOD51_RS06555	COG0523	cobalamin synthesis protein
IOD51_RS06560	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD51_RS06565	COG1309	transcriptional regulator
IOD51_RS06590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD51_RS06605	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
IOD51_RS06615	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD51_RS06620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD51_RS06625	COG1121	(ABC) transporter
IOD51_RS06630	COG0523	cobalamin synthesis protein
IOD51_RS06635	COG1114	Component of the transport system for branched-chain amino acids
IOD51_RS06645	COG0747	negative chemotaxis
IOD51_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD51_RS06660	COG4172	Belongs to the ABC transporter superfamily
IOD51_RS06665	COG1124	(ABC) transporter
IOD51_RS06690	COG1253	flavin adenine dinucleotide binding
IOD51_RS06695	COG1959	2 iron, 2 sulfur cluster binding
IOD51_RS06700	COG2910	NAD(P)H-binding
IOD51_RS06705	COG0583	DNA-binding transcription factor activity
IOD51_RS06710	COG2610	gluconate transmembrane transporter activity
IOD51_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS06730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD51_RS06745	COG1113	amino acid transport
IOD51_RS06750	COG0778	Nitroreductase
IOD51_RS06795	COG1609	Transcriptional regulator
IOD51_RS06800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD51_RS06805	COG1869	D-ribose catabolic process
IOD51_RS06810	COG1129	ABC transporter
IOD51_RS06815	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD51_RS06820	COG1879	ABC-type sugar transport system periplasmic component
IOD51_RS06830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IOD51_RS06835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IOD51_RS06840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IOD51_RS06850	COG1876	peptidase activity
IOD51_RS06855	COG1737	Transcriptional regulator
IOD51_RS06860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD51_RS06865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD51_RS06870	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD51_RS06885	COG2971	BadF BadG BcrA BcrD
IOD51_RS06895	COG3152	Membrane
IOD51_RS06905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IOD51_RS06910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD51_RS06915	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD51_RS06920	COG1288	antiporter activity
IOD51_RS06925	COG2814	Major facilitator Superfamily
IOD51_RS06930	COG0583	DNA-binding transcription factor activity
IOD51_RS06940	COG2318	DinB family
IOD51_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS06980	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS06990	COG1063	alcohol dehydrogenase
IOD51_RS07025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IOD51_RS07045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD51_RS07050	COG1695	Transcriptional regulator
IOD51_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS07065	COG0246	Mannitol dehydrogenase
IOD51_RS07075	COG3711	transcriptional antiterminator
IOD51_RS07080	COG2213	PTS system mannitol-specific
IOD51_RS07085	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IOD51_RS07090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IOD51_RS07095	COG2962	Rard protein
IOD51_RS07120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD51_RS07145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOD51_RS07150	COG0549	Belongs to the carbamate kinase family
IOD51_RS07175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD51_RS07185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD51_RS07215	COG0471	metal ion transport
IOD51_RS07225	COG4336	lyase activity
IOD51_RS07235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD51_RS07245	COG0363	glucosamine-6-phosphate deaminase activity
IOD51_RS07250	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IOD51_RS07260	COG1940	carbohydrate kinase activity
IOD51_RS07265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD51_RS07270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD51_RS07295	COG1124	(ABC) transporter
IOD51_RS07315	COG0747	negative chemotaxis
IOD51_RS07320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IOD51_RS07340	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
IOD51_RS07350	COG1054	Belongs to the UPF0176 family
IOD51_RS07355	COG3386	PFAM SMP-30 Gluconolaconase
IOD51_RS07365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD51_RS07370	COG0829	nickel cation binding
IOD51_RS07385	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IOD51_RS07390	COG0804	urea catabolic process
IOD51_RS07400	COG0831	urea catabolic process
IOD51_RS07405	COG4413	Urea transporter
IOD51_RS07410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD51_RS07425	COG1686	Belongs to the peptidase S11 family
IOD51_RS07435	COG4716	Myosin-crossreactive antigen
IOD51_RS07455	COG1131	(ABC) transporter
IOD51_RS07465	COG1476	TRANSCRIPTIONal
IOD51_RS07470	COG1959	2 iron, 2 sulfur cluster binding
IOD51_RS07475	COG0697	spore germination
IOD51_RS07480	COG2814	Major facilitator Superfamily
IOD51_RS07490	COG0737	Belongs to the 5'-nucleotidase family
IOD51_RS07500	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IOD51_RS07505	COG3639	organic phosphonate transmembrane transporter activity
IOD51_RS07515	COG0702	epimerase
IOD51_RS07540	COG3391	amine dehydrogenase activity
IOD51_RS07545	COG0201	protein transport
IOD51_RS07555	COG1073	alpha beta
IOD51_RS07565	COG0653	protein targeting
IOD51_RS07615	COG2814	Major facilitator Superfamily
IOD51_RS07630	COG2113	Glycine betaine
IOD51_RS07635	COG2409	Drug exporters of the RND superfamily
IOD51_RS07650	COG0583	DNA-binding transcription factor activity
IOD51_RS07655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD51_RS07665	COG1288	antiporter activity
IOD51_RS07670	COG3942	CHAP domain
IOD51_RS07670	COG3942	CHAP domain
IOD51_RS07670	COG1705	Flagellar rod assembly protein muramidase FlgJ
IOD51_RS07670	COG1705	Flagellar rod assembly protein muramidase FlgJ
IOD51_RS07705	COG2235	arginine
IOD51_RS07715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD51_RS07785	COG5658	integral membrane protein
IOD51_RS07790	COG2843	Capsule synthesis protein
IOD51_RS07795	COG3961	Belongs to the TPP enzyme family
IOD51_RS07805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOD51_RS07865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD51_RS07890	COG0297	glycogen (starch) synthase activity
IOD51_RS07910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD51_RS07915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD51_RS07920	COG1316	TRANSCRIPTIONal
IOD51_RS07925	COG1785	Belongs to the alkaline phosphatase family
IOD51_RS07940	COG0745	RESPONSE REGULATOR receiver
IOD51_RS07950	COG1136	(ABC) transporter
IOD51_RS07995	COG0175	sulfate reduction
IOD51_RS08000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IOD51_RS08005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD51_RS08020	COG0730	response to heat
IOD51_RS08025	COG2046	Belongs to the sulfate adenylyltransferase family
IOD51_RS08030	COG0529	Catalyzes the synthesis of activated sulfate
IOD51_RS08035	COG2851	Citrate transporter
IOD51_RS08040	COG3942	CHAP domain
IOD51_RS08050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD51_RS08055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD51_RS08060	COG1510	regulation of RNA biosynthetic process
IOD51_RS08065	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS08070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IOD51_RS08080	COG1473	amidohydrolase
IOD51_RS08090	COG1473	amidohydrolase
IOD51_RS08105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD51_RS08115	COG0583	DNA-binding transcription factor activity
IOD51_RS08120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD51_RS08120	COG0574	Belongs to the PEP-utilizing enzyme family
IOD51_RS08125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IOD51_RS08130	COG0579	oxidoreductase
IOD51_RS08135	COG2188	Transcriptional regulator
IOD51_RS08140	COG2723	6-phospho-beta-galactosidase activity
IOD51_RS08155	COG3588	fructose-bisphosphate aldolase
IOD51_RS08180	COG1464	Belongs to the NlpA lipoprotein family
IOD51_RS08190	COG0531	amino acid
IOD51_RS08195	COG0028	Belongs to the TPP enzyme family
IOD51_RS08200	COG3527	Alpha-acetolactate decarboxylase
IOD51_RS08230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD51_RS08240	COG0167	dihydroorotate dehydrogenase activity
IOD51_RS08245	COG3001	Fructosamine kinase
IOD51_RS08260	COG0596	Alpha beta hydrolase
IOD51_RS08310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD51_RS08325	COG2814	Major facilitator Superfamily
IOD51_RS08350	COG0741	lytic transglycosylase activity
IOD51_RS08360	COG1233	COG1233 Phytoene dehydrogenase and related
IOD51_RS08365	COG0463	Glycosyl transferase, family 2
IOD51_RS08370	COG1562	ergosterol biosynthetic process
IOD51_RS08375	COG1233	COG1233 Phytoene dehydrogenase and related
IOD51_RS08380	COG0436	Aminotransferase
IOD51_RS08390	COG2608	mercury ion transmembrane transporter activity
IOD51_RS08395	COG2217	Heavy metal translocating P-type atpase
IOD51_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS08410	COG0110	maltose O-acetyltransferase activity
IOD51_RS08415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IOD51_RS08420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD51_RS08425	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS08445	COG0598	Magnesium transport protein CorA
IOD51_RS08455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD51_RS08460	COG3425	synthase
IOD51_RS08465	COG0183	Belongs to the thiolase family
IOD51_RS08485	COG0583	DNA-binding transcription factor activity
IOD51_RS08490	COG1380	Effector of murein hydrolase LrgA
IOD51_RS08495	COG1346	cytolysis
IOD51_RS08500	COG0028	Belongs to the TPP enzyme family
IOD51_RS08515	COG1063	alcohol dehydrogenase
IOD51_RS08525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD51_RS08540	COG0697	spore germination
IOD51_RS08555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD51_RS08580	COG1070	Carbohydrate kinase
IOD51_RS08590	COG1760	l-serine dehydratase
IOD51_RS08595	COG1760	l-serine dehydratase
IOD51_RS08605	COG3764	Sortase (surface protein transpeptidase)
IOD51_RS08620	COG0778	Nitroreductase
IOD51_RS08625	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS08640	COG2514	catechol 2,3-dioxygenase activity
IOD51_RS08655	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS08660	COG1846	Transcriptional regulator
IOD51_RS08665	COG0346	lactoylglutathione lyase activity
IOD51_RS08670	COG0346	lactoylglutathione lyase activity
IOD51_RS08675	COG0400	carboxylic ester hydrolase activity
IOD51_RS08680	COG3949	Membrane
IOD51_RS08690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IOD51_RS08695	COG0586	Pfam SNARE associated Golgi protein
IOD51_RS08705	COG2022	thiamine diphosphate biosynthetic process
IOD51_RS08710	COG2022	thiamine diphosphate biosynthetic process
IOD51_RS08710	COG2104	thiamine diphosphate biosynthetic process
IOD51_RS08715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD51_RS08725	COG2271	Major facilitator Superfamily
IOD51_RS08730	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOD51_RS08740	COG4876	unkown
IOD51_RS08745	COG2357	RelA SpoT domain protein
IOD51_RS08755	COG0789	Transcriptional regulator
IOD51_RS08755	COG4978	Transcriptional regulator
IOD51_RS08760	COG1802	Transcriptional regulator
IOD51_RS08765	COG1070	Carbohydrate kinase
IOD51_RS08770	COG2610	gluconate transmembrane transporter activity
IOD51_RS08775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD51_RS08805	COG4221	oxidoreductase activity
IOD51_RS08810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD51_RS08815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IOD51_RS08825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IOD51_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS08835	COG1363	Peptidase, m42
IOD51_RS08845	COG0069	glutamate synthase activity
IOD51_RS08860	COG4619	ABC transporter
IOD51_RS08865	COG0390	transport system, permease component
IOD51_RS08870	COG2205	protein histidine kinase activity
IOD51_RS08875	COG0745	RESPONSE REGULATOR receiver
IOD51_RS08885	COG2814	Major facilitator Superfamily
IOD51_RS08890	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD51_RS08895	COG0531	amino acid
IOD51_RS08900	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IOD51_RS08905	COG1063	alcohol dehydrogenase
IOD51_RS08925	COG1174	glycine betaine transport
IOD51_RS08930	COG1346	cytolysis
IOD51_RS08935	COG1380	Effector of murein hydrolase LrgA
IOD51_RS08940	COG3279	Response regulator of the LytR AlgR family
IOD51_RS08945	COG3275	phosphorelay sensor kinase activity
IOD51_RS08955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IOD51_RS08960	COG3477	response to acidic pH
IOD51_RS08980	COG0531	amino acid
IOD51_RS08990	COG1113	amino acid transport
IOD51_RS09010	COG2226	methyltransferase
IOD51_RS09015	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IOD51_RS09020	COG2814	Major facilitator Superfamily
IOD51_RS09030	COG1929	Belongs to the glycerate kinase type-1 family
IOD51_RS09045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IOD51_RS09050	COG0741	lytic transglycosylase activity
IOD51_RS09055	COG0588	phosphoglycerate mutase activity
IOD51_RS09065	COG2814	Major facilitator Superfamily
IOD51_RS09070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD51_RS09075	COG0765	amino acid transport
IOD51_RS09080	COG1126	abc transporter atp-binding protein
IOD51_RS09100	COG3443	Belongs to the bacterial solute-binding protein 9 family
IOD51_RS09100	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD51_RS09105	COG2353	YceI-like domain
IOD51_RS09130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD51_RS09135	COG2146	nitrite reductase [NAD(P)H] activity
IOD51_RS09145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IOD51_RS09150	COG1140	nitrate reductase beta subunit
IOD51_RS09155	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IOD51_RS09160	COG2181	nitrate reductase activity
IOD51_RS09170	COG4585	Histidine kinase
IOD51_RS09175	COG2197	response regulator
IOD51_RS09180	COG2223	nitrite transmembrane transporter activity
IOD51_RS09190	COG1846	Transcriptional regulator
IOD51_RS09210	COG3871	stress protein (general stress protein 26)
IOD51_RS09225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD51_RS09225	COG1263	PTS System
IOD51_RS09240	COG1511	domain protein
IOD51_RS09250	COG0534	Mate efflux family protein
IOD51_RS09270	COG0492	ferredoxin-NADP+ reductase activity
IOD51_RS09280	COG0604	alcohol dehydrogenase
IOD51_RS09285	COG2822	iron ion transport
IOD51_RS09290	COG2837	iron assimilation
IOD51_RS09295	COG0672	)-iron permease
IOD51_RS09300	COG0805	protein transport
IOD51_RS09305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD51_RS09315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IOD51_RS09320	COG1620	l-lactate permease
IOD51_RS09325	COG0438	transferase activity, transferring glycosyl groups
IOD51_RS09330	COG0579	oxidoreductase
IOD51_RS09340	COG5002	protein histidine kinase activity
IOD51_RS09340	COG3850	Histidine kinase
IOD51_RS09345	COG0745	RESPONSE REGULATOR receiver
IOD51_RS09350	COG0577	efflux transmembrane transporter activity
IOD51_RS09355	COG1136	(ABC) transporter
IOD51_RS09370	COG4640	response to antibiotic
IOD51_RS09375	COG2814	Major facilitator Superfamily
IOD51_RS09385	COG1566	PFAM secretion protein HlyD family protein
IOD51_RS09390	COG2814	Major facilitator Superfamily
IOD51_RS09415	COG0598	Magnesium transport protein CorA
IOD51_RS09420	COG1304	FMN binding
IOD51_RS09425	COG0786	glutamate:sodium symporter activity
IOD51_RS09430	COG2094	Belongs to the DNA glycosylase MPG family
IOD51_RS09435	COG1396	sequence-specific DNA binding
IOD51_RS09445	COG1742	UPF0060 membrane protein
IOD51_RS09450	COG2017	converts alpha-aldose to the beta-anomer
IOD51_RS09455	COG2258	MOSC domain
IOD51_RS09460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IOD51_RS09465	COG1266	CAAX protease self-immunity
IOD51_RS09470	COG0010	Belongs to the arginase family
IOD51_RS09475	COG0659	secondary active sulfate transmembrane transporter activity
IOD51_RS09480	COG1473	amidohydrolase
IOD51_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
IOD51_RS09490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD51_RS09505	COG1737	Transcriptional regulator
IOD51_RS09510	COG1263	PTS System
IOD51_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD51_RS09520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD51_RS09540	COG1113	amino acid transport
IOD51_RS09550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD51_RS09550	COG1263	PTS System
IOD51_RS09555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IOD51_RS09570	COG2378	regulation of single-species biofilm formation
IOD51_RS09580	COG1316	TRANSCRIPTIONal
IOD51_RS09585	COG3383	formate dehydrogenase (NAD+) activity
IOD51_RS09590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD51_RS09610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD51_RS09615	COG2076	Multidrug Resistance protein
IOD51_RS09620	COG2076	Multidrug Resistance protein
IOD51_RS09625	COG3942	CHAP domain
IOD51_RS09640	COG1757	Na H antiporter
IOD51_RS09645	COG3942	CHAP domain
IOD51_RS09670	COG1960	acyl-CoA dehydrogenase activity
IOD51_RS09675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IOD51_RS09685	COG1268	BioY protein
IOD51_RS09695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD51_RS09700	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD51_RS09705	COG4149	molybdate abc transporter
IOD51_RS09710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOD51_RS09715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD51_RS09725	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD51_RS09750	COG0746	molybdenum cofactor guanylyltransferase activity
IOD51_RS09755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOD51_RS09780	COG2348	transferase activity, transferring amino-acyl groups
IOD51_RS09785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD51_RS09810	COG4975	Glucose uptake
IOD51_RS09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD51_RS09820	COG0551	DNA topoisomerase type I activity
IOD51_RS09825	COG2252	PERMEase
IOD51_RS09840	COG0051	transcription antitermination factor activity, RNA binding
IOD51_RS09845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD51_RS09850	COG0088	Forms part of the polypeptide exit tunnel
IOD51_RS09855	COG0089	rRNA binding
IOD51_RS09860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOD51_RS09865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD51_RS09870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOD51_RS09875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOD51_RS09880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD51_RS09885	COG0255	Belongs to the universal ribosomal protein uL29 family
IOD51_RS09890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOD51_RS09895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IOD51_RS09900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOD51_RS09905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOD51_RS09915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOD51_RS09920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IOD51_RS09925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOD51_RS09930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOD51_RS09935	COG1841	ribosomal large subunit assembly
IOD51_RS09940	COG0200	Binds to the 23S rRNA
IOD51_RS09945	COG0201	protein transport
IOD51_RS09950	COG0563	adenylate kinase activity
IOD51_RS09955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD51_RS09960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD51_RS09965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOD51_RS09975	COG0202	RNA polymerase activity
IOD51_RS09980	COG0203	ribosomal protein L17
IOD51_RS09985	COG1122	ATPase activity
IOD51_RS09990	COG1122	ATPase activity
IOD51_RS10000	COG0101	tRNA pseudouridine synthase activity
IOD51_RS10005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD51_RS10015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD51_RS10020	COG1349	DNA-binding transcription factor activity
IOD51_RS10025	COG0698	ribose 5-phosphate isomerase
IOD51_RS10030	COG0698	ribose 5-phosphate isomerase
IOD51_RS10035	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD51_RS10040	COG3684	Belongs to the aldolase LacD family
IOD51_RS10045	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD51_RS10050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD51_RS10050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD51_RS10055	COG2723	6-phospho-beta-galactosidase activity
IOD51_RS10065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD51_RS10070	COG0604	alcohol dehydrogenase
IOD51_RS10075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD51_RS10090	COG1302	Protein conserved in bacteria
IOD51_RS10095	COG4264	IucA IucC family
IOD51_RS10100	COG2814	Major facilitator Superfamily
IOD51_RS10105	COG4264	IucA IucC family
IOD51_RS10110	COG3457	Alanine racemase
IOD51_RS10115	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IOD51_RS10120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS10125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD51_RS10130	COG3314	Sporulation integral membrane protein YlbJ
IOD51_RS10135	COG2329	Antibiotic biosynthesis monooxygenase
IOD51_RS10145	COG1988	membrane-bound metal-dependent
IOD51_RS10150	COG4284	Utp--glucose-1-phosphate uridylyltransferase
IOD51_RS10155	COG1272	protein, Hemolysin III
IOD51_RS10170	COG2814	Major facilitator Superfamily
IOD51_RS10175	COG0489	protein tyrosine kinase activity
IOD51_RS10225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IOD51_RS10235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD51_RS10245	COG0561	phosphatase activity
IOD51_RS10265	COG0640	Transcriptional regulator
IOD51_RS10270	COG0702	epimerase
IOD51_RS10275	COG1482	cell wall glycoprotein biosynthetic process
IOD51_RS10295	COG0783	Belongs to the Dps family
IOD51_RS10300	COG0813	purine-nucleoside phosphorylase activity
IOD51_RS10305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IOD51_RS10310	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IOD51_RS10315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IOD51_RS10325	COG1854	S-ribosylhomocysteine lyase activity
IOD51_RS10345	COG5146	pantothenate kinase activity
IOD51_RS10360	COG0504	CTP synthase activity
IOD51_RS10370	COG0191	fructose-bisphosphate aldolase activity
IOD51_RS10375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD51_RS10385	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS10390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD51_RS10395	COG0254	rRNA binding
IOD51_RS10400	COG1435	thymidine kinase activity
IOD51_RS10405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IOD51_RS10410	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD51_RS10415	COG0009	L-threonylcarbamoyladenylate synthase
IOD51_RS10420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD51_RS10425	COG4475	Protein of unknown function (DUF436)
IOD51_RS10430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD51_RS10435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IOD51_RS10440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD51_RS10450	COG0356	it plays a direct role in the translocation of protons across the membrane
IOD51_RS10455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD51_RS10460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOD51_RS10465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD51_RS10470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD51_RS10475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOD51_RS10480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD51_RS10485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOD51_RS10495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD51_RS10500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD51_RS10510	COG0629	single-stranded DNA binding
IOD51_RS10515	COG1388	LysM domain
IOD51_RS10520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD51_RS10530	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IOD51_RS10535	COG0352	thiamine-phosphate diphosphorylase activity
IOD51_RS10540	COG0706	membrane insertase activity
IOD51_RS10545	COG1418	mRNA catabolic process
IOD51_RS10550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD51_RS10555	COG1937	Protein conserved in bacteria
IOD51_RS10570	COG0772	Belongs to the SEDS family
IOD51_RS10575	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD51_RS10580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD51_RS10585	COG0513	Belongs to the DEAD box helicase family
IOD51_RS10595	COG3428	Bacterial PH domain
IOD51_RS10600	COG3402	PFAM membrane-flanked domain
IOD51_RS10605	COG0736	holo-[acyl-carrier-protein] synthase activity
IOD51_RS10610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD51_RS10620	COG2337	Toxic component of a toxin-antitoxin (TA) module
IOD51_RS10625	COG2208	phosphoserine phosphatase activity
IOD51_RS10640	COG1191	sigma factor activity
IOD51_RS10645	COG2183	response to ionizing radiation
IOD51_RS10680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD51_RS10685	COG0066	3-isopropylmalate dehydratase activity
IOD51_RS10690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOD51_RS10695	COG0473	3-isopropylmalate dehydrogenase activity
IOD51_RS10705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD51_RS10710	COG0440	acetolactate synthase activity
IOD51_RS10715	COG0028	Belongs to the TPP enzyme family
IOD51_RS10720	COG0129	dihydroxy-acid dehydratase activity
IOD51_RS10725	COG0802	atpase or kinase
IOD51_RS10730	COG1214	PFAM Peptidase M22, glycoprotease
IOD51_RS10735	COG0456	acetyltransferase
IOD51_RS10740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOD51_RS10745	COG0488	(ABC) transporter
IOD51_RS10750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IOD51_RS10755	COG2391	methyltransferase activity
IOD51_RS10760	COG0425	Belongs to the sulfur carrier protein TusA family
IOD51_RS10765	COG0004	ammonium transporteR
IOD51_RS10775	COG1621	beta-fructofuranosidase activity
IOD51_RS10780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD51_RS10785	COG3279	Response regulator of the LytR AlgR family
IOD51_RS10800	COG4512	PFAM Accessory gene regulator B
IOD51_RS10825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD51_RS10830	COG0459	protein refolding
IOD51_RS10870	COG1725	Transcriptional regulator
IOD51_RS10885	COG1131	(ABC) transporter
IOD51_RS10925	COG2706	6-phosphogluconolactonase activity
IOD51_RS10930	COG1012	belongs to the aldehyde dehydrogenase family
IOD51_RS10935	COG1227	inorganic diphosphatase activity
IOD51_RS10940	COG1335	isochorismatase
IOD51_RS10950	COG0077	Prephenate dehydratase
IOD51_RS10950	COG1605	Chorismate mutase
IOD51_RS10960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IOD51_RS10965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOD51_RS10970	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IOD51_RS10980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD51_RS10985	COG4496	protein, YerC YecD
IOD51_RS10990	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IOD51_RS10995	COG0210	DNA helicase
IOD51_RS11000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD51_RS11005	COG4851	CamS sex pheromone cAM373 precursor
IOD51_RS11010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD51_RS11015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD51_RS11020	COG0154	amidase activity
IOD51_RS11025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOD51_RS11030	COG1597	lipid kinase activity
IOD51_RS11035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD51_RS11045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD51_RS11055	COG1528	Iron-storage protein
IOD51_RS11070	COG4129	membrane
IOD51_RS11075	COG0024	Methionine aminopeptidase
IOD51_RS11080	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD51_RS11095	COG4585	Histidine kinase
IOD51_RS11100	COG2197	response regulator
IOD51_RS11105	COG1295	ribonuclease BN
IOD51_RS11115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOD51_RS11120	COG4840	Belongs to the UPF0435 family
IOD51_RS11125	COG2309	aminopeptidase activity
IOD51_RS11130	COG1607	acyl-coa hydrolase
IOD51_RS11135	COG0535	radical SAM domain protein
IOD51_RS11145	COG0693	protein deglycase activity
IOD51_RS11150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD51_RS11155	COG2137	regulation of response to DNA damage stimulus
IOD51_RS11165	COG1388	LysM domain
IOD51_RS11165	COG1134	teichoic acid transport
IOD51_RS11175	COG1988	membrane-bound metal-dependent
IOD51_RS11180	COG1194	a g-specific adenine glycosylase
IOD51_RS11185	COG3557	Belongs to the UPF0374 family
IOD51_RS11195	COG4129	membrane
IOD51_RS11200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD51_RS11205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD51_RS11210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD51_RS11215	COG0735	belongs to the Fur family
IOD51_RS11385	COG0765	amino acid transport
IOD51_RS11390	COG1126	abc transporter atp-binding protein
IOD51_RS11395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD51_RS11420	COG0114	fumarate hydratase activity
IOD51_RS11425	COG0564	pseudouridine synthase activity
IOD51_RS11430	COG2203	Gaf domain
IOD51_RS11430	COG4585	Histidine kinase
IOD51_RS11435	COG2197	response regulator
IOD51_RS11445	COG4399	Belongs to the UPF0754 family
IOD51_RS11450	COG3679	Belongs to the UPF0342 family
IOD51_RS11460	COG4717	serine-type aminopeptidase activity
IOD51_RS11465	COG3481	metal-dependent phosphohydrolase, HD sub domain
IOD51_RS11470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD51_RS11485	COG0537	adenosine 5'-monophosphoramidase activity
IOD51_RS11490	COG1131	(ABC) transporter
IOD51_RS11495	COG4473	ABC transporter
IOD51_RS11505	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOD51_RS11510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOD51_RS11515	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IOD51_RS11570	COG0318	PFAM AMP-dependent synthetase and ligase
IOD51_RS11580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD51_RS11585	COG0494	nUDIX hydrolase
IOD51_RS11590	COG1506	peptidase
IOD51_RS11595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IOD51_RS11600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOD51_RS11610	COG0656	L-ascorbic acid biosynthetic process
IOD51_RS11615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD51_RS11620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD51_RS11630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD51_RS11655	COG3266	domain, Protein
IOD51_RS11655	COG5632	N-Acetylmuramoyl-L-alanine amidase
IOD51_RS11655	COG4193	domain, Protein
IOD51_RS11665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD51_RS11665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD51_RS11670	COG0307	riboflavin synthase, alpha
IOD51_RS11675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD51_RS11675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD51_RS11680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IOD51_RS11685	COG0506	proline dehydrogenase activity
IOD51_RS11690	COG2267	carboxylic ester hydrolase activity
IOD51_RS11700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IOD51_RS11705	COG1242	4 iron, 4 sulfur cluster binding
IOD51_RS11710	COG2814	Major facilitator Superfamily
IOD51_RS11715	COG0495	leucyl-tRNA aminoacylation
IOD51_RS11735	COG2081	HI0933 family
IOD51_RS11740	COG2244	polysaccharide biosynthetic process
IOD51_RS11745	COG1187	pseudouridine synthase activity
IOD51_RS11755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD51_RS11765	COG0510	thiamine kinase activity
IOD51_RS11770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD51_RS11775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD51_RS11785	COG1363	Peptidase, m42
IOD51_RS11790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD51_RS11795	COG4848	Belongs to the UPF0354 family
IOD51_RS11800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD51_RS11805	COG1674	ftsk spoiiie
IOD51_RS11810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD51_RS11815	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IOD51_RS11825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IOD51_RS11825	COG1605	Chorismate mutase
IOD51_RS11830	COG1609	Transcriptional regulator
IOD51_RS11840	COG0454	-acetyltransferase
IOD51_RS11845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD51_RS11850	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IOD51_RS11860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOD51_RS11865	COG1846	Transcriptional regulator
IOD51_RS11870	COG0477	Major facilitator Superfamily
IOD51_RS11875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD51_RS11880	COG0204	Acyl-transferase
IOD51_RS11900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD51_RS11900	COG1263	PTS System
IOD51_RS11910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD51_RS11915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD51_RS11920	COG1764	response to oxidative stress
IOD51_RS11925	COG0584	glycerophosphoryl diester phosphodiesterase
IOD51_RS11930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOD51_RS11935	COG1956	GAF domain-containing protein
IOD51_RS11945	COG1104	cysteine desulfurase activity
IOD51_RS11950	COG0301	tRNA thio-modification
IOD51_RS11960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOD51_RS11965	COG0827	DNA restriction-modification system
IOD51_RS11970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOD51_RS11975	COG0589	response to stress
IOD51_RS11980	COG0686	Belongs to the AlaDH PNT family
IOD51_RS11985	COG0006	proline dipeptidase activity
IOD51_RS11990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IOD51_RS12000	COG4109	DRTGG domain
IOD51_RS12005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IOD51_RS12010	COG0587	DNA-directed DNA polymerase activity
IOD51_RS12015	COG0281	malic enzyme
IOD51_RS12020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IOD51_RS12025	COG0825	malonyl-CoA metabolic process
IOD51_RS12030	COG0205	6-phosphofructokinase activity
IOD51_RS12035	COG0469	pyruvate kinase activity
IOD51_RS12040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD51_RS12045	COG1113	amino acid transport
IOD51_RS12050	COG0372	Belongs to the citrate synthase family
IOD51_RS12055	COG0538	isocitrate dehydrogenase activity
IOD51_RS12060	COG0745	RESPONSE REGULATOR receiver
IOD51_RS12065	COG5002	protein histidine kinase activity
IOD51_RS12070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD51_RS12070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD51_RS12075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD51_RS12080	COG0237	dephospho-CoA kinase activity
IOD51_RS12085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD51_RS12090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IOD51_RS12095	COG3611	Membrane attachment protein
IOD51_RS12100	COG1484	DNA-dependent DNA replication
IOD51_RS12105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD51_RS12110	COG0833	amino acid
IOD51_RS12115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOD51_RS12120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD51_RS12125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOD51_RS12130	COG4112	unkown
IOD51_RS12140	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOD51_RS12145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD51_RS12150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IOD51_RS12155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOD51_RS12160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD51_RS12165	COG0181	hydroxymethylbilane synthase activity
IOD51_RS12180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD51_RS12190	COG2818	Glycosylase
IOD51_RS12195	COG0525	valine-tRNA ligase activity
IOD51_RS12200	COG0285	dihydrofolate synthase activity
IOD51_RS12210	COG2003	Belongs to the UPF0758 family
IOD51_RS12230	COG1792	Involved in formation and maintenance of cell shape
IOD51_RS12240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOD51_RS12245	COG2868	ribosomal protein
IOD51_RS12250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOD51_RS12255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOD51_RS12260	COG4492	Belongs to the UPF0735 family
IOD51_RS12265	COG0632	four-way junction helicase activity
IOD51_RS12270	COG2255	four-way junction helicase activity
IOD51_RS12275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IOD51_RS12280	COG0343	queuine tRNA-ribosyltransferase activity
IOD51_RS12285	COG1862	Preprotein translocase
IOD51_RS12290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD51_RS12290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD51_RS12295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IOD51_RS12295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD51_RS12300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD51_RS12305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD51_RS12310	COG1490	D-aminoacyl-tRNA deacylase activity
IOD51_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD51_RS12320	COG0124	histidyl-tRNA synthetase
IOD51_RS12325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOD51_RS12335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD51_RS12340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD51_RS12345	COG1959	2 iron, 2 sulfur cluster binding
IOD51_RS12350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD51_RS12355	COG1104	cysteine desulfurase activity
IOD51_RS12360	COG0482	sulfurtransferase activity
IOD51_RS12370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD51_RS12375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOD51_RS12380	COG4472	Bacterial protein of unknown function (DUF965)
IOD51_RS12385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOD51_RS12390	COG3906	Belongs to the UPF0473 family
IOD51_RS12400	COG0826	peptidase U32
IOD51_RS12405	COG0826	peptidase U32
IOD51_RS12410	COG0572	uridine kinase
IOD51_RS12415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD51_RS12420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD51_RS12425	COG1984	allophanate hydrolase subunit 2
IOD51_RS12430	COG0511	ligase activity, forming carbon-carbon bonds
IOD51_RS12435	COG0439	Biotin carboxylase
IOD51_RS12440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOD51_RS12445	COG1914	H( )-stimulated, divalent metal cation uptake system
IOD51_RS12450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD51_RS12455	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IOD51_RS12460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IOD51_RS12465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD51_RS12470	COG1534	Rna-binding protein
IOD51_RS12475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IOD51_RS12480	COG1713	HD superfamily hydrolase involved in NAD metabolism
IOD51_RS12485	COG0799	negative regulation of ribosome biogenesis
IOD51_RS12490	COG2226	methyltransferase
IOD51_RS12495	COG1596	polysaccharide export
IOD51_RS12495	COG1555	photosystem II stabilization
IOD51_RS12500	COG2131	deaminase
IOD51_RS12505	COG0658	competence protein
IOD51_RS12505	COG2333	competence protein COMEC
IOD51_RS12515	COG0658	competence protein
IOD51_RS12515	COG2333	competence protein COMEC
IOD51_RS12520	COG1466	dna polymerase III delta subunit
IOD51_RS12525	COG0268	Binds directly to 16S ribosomal RNA
IOD51_RS12530	COG0481	GTPase activity
IOD51_RS12535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD51_RS12540	COG1420	regulation of RNA biosynthetic process
IOD51_RS12545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD51_RS12550	COG0443	Heat shock 70 kDa protein
IOD51_RS12555	COG0484	heat shock protein binding
IOD51_RS12560	COG2264	protein methyltransferase activity
IOD51_RS12565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD51_RS12570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD51_RS12580	COG1030	water channel activity
IOD51_RS12585	COG4864	UPF0365 protein
IOD51_RS12595	COG1702	phosphate starvation-inducible protein PhoH
IOD51_RS12605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOD51_RS12615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD51_RS12620	COG1381	Involved in DNA repair and RecF pathway recombination
IOD51_RS12625	COG0423	glycine-tRNA ligase activity
IOD51_RS12630	COG0517	IMP dehydrogenase activity
IOD51_RS12635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IOD51_RS12645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD51_RS12650	COG2384	SAM-dependent methyltransferase
IOD51_RS12655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD51_RS12660	COG0513	Belongs to the DEAD box helicase family
IOD51_RS12665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IOD51_RS12670	COG1121	(ABC) transporter
IOD51_RS12675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD51_RS12685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD51_RS12690	COG0768	penicillin binding
IOD51_RS12695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD51_RS12700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD51_RS12705	COG0705	Rhomboid family
IOD51_RS12705	COG0457	Tetratricopeptide repeat
IOD51_RS12710	COG4483	Protein conserved in bacteria
IOD51_RS12715	COG1940	carbohydrate kinase activity
IOD51_RS12720	COG0011	TIGRFAM Protein of
IOD51_RS12725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD51_RS12730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD51_RS12735	COG1459	type II secretion system
IOD51_RS12740	COG4537	Required for transformation and DNA binding
IOD51_RS12750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD51_RS12755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IOD51_RS12760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD51_RS12765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IOD51_RS12770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD51_RS12775	COG0095	Lipoate-protein ligase
IOD51_RS12790	COG0006	proline dipeptidase activity
IOD51_RS12795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD51_RS12800	COG0511	ligase activity, forming carbon-carbon bonds
IOD51_RS12805	COG0439	Biotin carboxylase
IOD51_RS12810	COG1302	Protein conserved in bacteria
IOD51_RS12815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD51_RS12820	COG1570	exodeoxyribonuclease VII activity
IOD51_RS12835	COG1438	arginine binding
IOD51_RS12840	COG0497	DNA recombination
IOD51_RS12845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD51_RS12850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD51_RS12855	COG0022	dehydrogenase e1 component
IOD51_RS12860	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD51_RS12870	COG4129	membrane
IOD51_RS12880	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD51_RS12890	COG1609	Transcriptional regulator
IOD51_RS12895	COG0366	Alpha amylase catalytic
IOD51_RS12905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IOD51_RS12910	COG1234	tRNA 3'-trailer cleavage
IOD51_RS12915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD51_RS12920	COG0300	oxidoreductase activity
IOD51_RS12930	COG0667	Aldo Keto reductase
IOD51_RS12935	COG0494	nUDIX hydrolase
IOD51_RS12940	COG0735	belongs to the Fur family
IOD51_RS12945	COG4974	Belongs to the 'phage' integrase family
IOD51_RS12950	COG1547	Domain of unknown function (DUF309)
IOD51_RS12955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOD51_RS12960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOD51_RS12965	COG1187	pseudouridine synthase activity
IOD51_RS12970	COG0745	RESPONSE REGULATOR receiver
IOD51_RS12985	COG1141	Ferredoxin
IOD51_RS12995	COG0514	ATP-dependent DNA helicase (RecQ)
IOD51_RS13000	COG1388	LysM domain
IOD51_RS13005	COG0492	ferredoxin-NADP+ reductase activity
IOD51_RS13015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IOD51_RS13020	COG0539	negative regulation of cytoplasmic translation
IOD51_RS13025	COG1160	GTP binding
IOD51_RS13030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD51_RS13045	COG2226	methyltransferase
IOD51_RS13050	COG0142	geranyltranstransferase activity
IOD51_RS13055	COG0105	UTP biosynthetic process
IOD51_RS13060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOD51_RS13065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOD51_RS13070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD51_RS13075	COG0457	Tetratricopeptide repeat
IOD51_RS13080	COG5582	Belongs to the UPF0302 family
IOD51_RS13085	COG4347	Protein of unknown function (DUF1405)
IOD51_RS13090	COG2738	Putative neutral zinc metallopeptidase
IOD51_RS13095	COG1694	Mazg nucleotide pyrophosphohydrolase
IOD51_RS13100	COG0438	transferase activity, transferring glycosyl groups
IOD51_RS13105	COG0617	tRNA 3'-terminal CCA addition
IOD51_RS13115	COG1199	ATP-dependent helicase activity
IOD51_RS13115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD51_RS13120	COG0017	Asparaginyl-tRNA synthetase
IOD51_RS13125	COG3935	DnaD domain protein
IOD51_RS13130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD51_RS13140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD51_RS13140	COG4499	WXG100 protein secretion system (Wss), protein YukC
IOD51_RS13145	COG3331	DNA recombination
IOD51_RS13155	COG4474	Belongs to the UPF0398 family
IOD51_RS13160	COG3599	regulation of cell shape
IOD51_RS13170	COG0116	Belongs to the methyltransferase superfamily
IOD51_RS13180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IOD51_RS13275	COG0640	Transcriptional regulator
IOD51_RS13330	COG1192	Involved in chromosome partitioning
IOD51_RS13365	COG1388	LysM domain
IOD51_RS13385	COG2217	Heavy metal translocating P-type atpase
IOD51_RS13390	COG1937	Protein conserved in bacteria
IOD51_RS13455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IOD51_RS13465	COG0488	(ABC) transporter