locus-tag	class	description
SH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SH_RS00010	COG0592	DNA-directed DNA polymerase activity
SH_RS00015	COG2501	S4 domain
SH_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SH_RS00025	COG0187	DNA topoisomerase II activity
SH_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SH_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SH_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SH_RS00045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SH_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SH_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SH_RS00070	COG0359	binds to the 23S rRNA
SH_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
SH_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SH_RS00100	COG0745	RESPONSE REGULATOR receiver
SH_RS00105	COG5002	protein histidine kinase activity
SH_RS00110	COG4863	YycH protein
SH_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SH_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SH_RS00150	COG0745	RESPONSE REGULATOR receiver
SH_RS00155	COG2205	protein histidine kinase activity
SH_RS00165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SH_RS00170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SH_RS00175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SH_RS00185	COG0730	response to heat
SH_RS00205	COG2070	2-Nitropropane dioxygenase
SH_RS00215	COG0477	Major facilitator Superfamily
SH_RS00285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SH_RS00290	COG0732	type I restriction modification DNA specificity domain
SH_RS00295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SH_RS00310	COG0076	glutamate decarboxylase activity
SH_RS00315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH_RS00320	COG2814	Major facilitator Superfamily
SH_RS00325	COG0366	Alpha amylase catalytic
SH_RS00330	COG1609	Transcriptional regulator
SH_RS00335	COG2207	Transcriptional regulator
SH_RS00360	COG1131	(ABC) transporter
SH_RS00400	COG0584	glycerophosphoryl diester phosphodiesterase
SH_RS00405	COG2030	dehydratase
SH_RS00420	COG0789	Transcriptional regulator
SH_RS00430	COG0702	epimerase
SH_RS00435	COG2130	NADP-dependent
SH_RS00450	COG0640	Transcriptional regulator
SH_RS00455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH_RS00475	COG2132	Multicopper oxidase
SH_RS00480	COG1388	LysM domain
SH_RS00485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH_RS00490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SH_RS00515	COG0640	Transcriptional regulator
SH_RS00530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SH_RS00545	COG0668	transmembrane transport
SH_RS00560	COG0523	cobalamin synthesis protein
SH_RS00565	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH_RS00575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SH_RS00595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SH_RS00620	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SH_RS00630	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH_RS00635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SH_RS00640	COG1121	(ABC) transporter
SH_RS00645	COG0523	cobalamin synthesis protein
SH_RS00650	COG1114	Component of the transport system for branched-chain amino acids
SH_RS00660	COG0747	negative chemotaxis
SH_RS00670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH_RS00675	COG4172	Belongs to the ABC transporter superfamily
SH_RS00705	COG0789	Transcriptional regulator
SH_RS00715	COG1253	flavin adenine dinucleotide binding
SH_RS00725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SH_RS00740	COG1113	amino acid transport
SH_RS00745	COG0778	Nitroreductase
SH_RS00790	COG1609	Transcriptional regulator
SH_RS00795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH_RS00800	COG1869	D-ribose catabolic process
SH_RS00805	COG1129	ABC transporter
SH_RS00810	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH_RS00815	COG1879	ABC-type sugar transport system periplasmic component
SH_RS00825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SH_RS00830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SH_RS00835	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SH_RS00845	COG1876	peptidase activity
SH_RS00850	COG1737	Transcriptional regulator
SH_RS00855	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH_RS00860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH_RS00865	COG1447	Phosphotransferase system cellobiose-specific component IIA
SH_RS00880	COG2971	BadF BadG BcrA BcrD
SH_RS00890	COG3152	Membrane
SH_RS00900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SH_RS00910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SH_RS00915	COG1288	antiporter activity
SH_RS00930	COG2318	DinB family
SH_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS00975	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS00980	COG1063	alcohol dehydrogenase
SH_RS00985	COG1846	Transcriptional regulator
SH_RS00990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH_RS01005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SH_RS01015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH_RS01020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SH_RS01025	COG0022	dehydrogenase e1 component
SH_RS01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
SH_RS01035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH_RS01040	COG1695	Transcriptional regulator
SH_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS01060	COG0246	Mannitol dehydrogenase
SH_RS01070	COG3711	transcriptional antiterminator
SH_RS01075	COG2213	PTS system mannitol-specific
SH_RS01085	COG2962	Rard protein
SH_RS01095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH_RS01145	COG0789	Transcriptional regulator
SH_RS01170	COG2314	TM2 domain
SH_RS01180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SH_RS01185	COG0549	Belongs to the carbamate kinase family
SH_RS01195	COG3093	addiction module antidote protein HigA
SH_RS01225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SH_RS01235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SH_RS01245	COG0471	metal ion transport
SH_RS01250	COG5505	Protein of unknown function (DUF819)
SH_RS01255	COG4336	lyase activity
SH_RS01265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SH_RS01275	COG0363	glucosamine-6-phosphate deaminase activity
SH_RS01280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SH_RS01295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SH_RS01300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SH_RS01325	COG1124	(ABC) transporter
SH_RS01330	COG0444	Belongs to the ABC transporter superfamily
SH_RS01350	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SH_RS01370	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SH_RS01380	COG1054	Belongs to the UPF0176 family
SH_RS01385	COG3386	PFAM SMP-30 Gluconolaconase
SH_RS01390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SH_RS01410	COG4716	Myosin-crossreactive antigen
SH_RS01430	COG1131	(ABC) transporter
SH_RS01440	COG1476	TRANSCRIPTIONal
SH_RS01445	COG1959	2 iron, 2 sulfur cluster binding
SH_RS01450	COG0697	spore germination
SH_RS01455	COG2814	Major facilitator Superfamily
SH_RS01465	COG0737	Belongs to the 5'-nucleotidase family
SH_RS01475	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SH_RS01480	COG3639	organic phosphonate transmembrane transporter activity
SH_RS01530	COG0201	protein transport
SH_RS01540	COG1073	alpha beta
SH_RS01550	COG0653	protein targeting
SH_RS01565	COG0642	Histidine kinase
SH_RS01595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SH_RS01620	COG2814	Major facilitator Superfamily
SH_RS01630	COG2113	Glycine betaine
SH_RS01635	COG2409	Drug exporters of the RND superfamily
SH_RS01640	COG0583	DNA-binding transcription factor activity
SH_RS01645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SH_RS01655	COG1288	antiporter activity
SH_RS01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS01660	COG1263	PTS System
SH_RS01660	COG2190	(PTS) system
SH_RS01665	COG1705	Flagellar rod assembly protein muramidase FlgJ
SH_RS01665	COG3942	CHAP domain
SH_RS01665	COG1705	Flagellar rod assembly protein muramidase FlgJ
SH_RS01665	COG3942	CHAP domain
SH_RS01700	COG2235	arginine
SH_RS01710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH_RS01735	COG5658	integral membrane protein
SH_RS01740	COG2843	Capsule synthesis protein
SH_RS01745	COG3961	Belongs to the TPP enzyme family
SH_RS01790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SH_RS01795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SH_RS01830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SH_RS01855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SH_RS01860	COG1316	TRANSCRIPTIONal
SH_RS01865	COG1785	Belongs to the alkaline phosphatase family
SH_RS01875	COG2205	protein histidine kinase activity
SH_RS01880	COG1136	(ABC) transporter
SH_RS01915	COG0175	sulfate reduction
SH_RS01920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SH_RS01925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SH_RS01940	COG0730	response to heat
SH_RS01945	COG2046	Belongs to the sulfate adenylyltransferase family
SH_RS01950	COG0529	Catalyzes the synthesis of activated sulfate
SH_RS01955	COG2851	Citrate transporter
SH_RS01970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SH_RS01975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SH_RS01980	COG1510	regulation of RNA biosynthetic process
SH_RS01985	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS01990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SH_RS02000	COG1473	amidohydrolase
SH_RS02010	COG1473	amidohydrolase
SH_RS02025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SH_RS02035	COG0583	DNA-binding transcription factor activity
SH_RS02045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH_RS02045	COG0574	Belongs to the PEP-utilizing enzyme family
SH_RS02050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SH_RS02055	COG0579	oxidoreductase
SH_RS02075	COG3588	fructose-bisphosphate aldolase
SH_RS02080	COG0563	adenylate kinase activity
SH_RS02110	COG1464	Belongs to the NlpA lipoprotein family
SH_RS02120	COG0531	amino acid
SH_RS02125	COG0028	Belongs to the TPP enzyme family
SH_RS02130	COG3527	Alpha-acetolactate decarboxylase
SH_RS02160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SH_RS02170	COG0167	dihydroorotate dehydrogenase activity
SH_RS02175	COG3001	Fructosamine kinase
SH_RS02215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SH_RS02240	COG0741	lytic transglycosylase activity
SH_RS02250	COG1233	COG1233 Phytoene dehydrogenase and related
SH_RS02255	COG0463	Glycosyl transferase, family 2
SH_RS02260	COG1562	ergosterol biosynthetic process
SH_RS02265	COG1233	COG1233 Phytoene dehydrogenase and related
SH_RS02270	COG0436	Aminotransferase
SH_RS02280	COG2608	mercury ion transmembrane transporter activity
SH_RS02285	COG2217	Heavy metal translocating P-type atpase
SH_RS02295	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS02300	COG0110	maltose O-acetyltransferase activity
SH_RS02305	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS02330	COG0598	Magnesium transport protein CorA
SH_RS02340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SH_RS02345	COG3425	synthase
SH_RS02360	COG1388	LysM domain
SH_RS02360	COG3942	CHAP domain
SH_RS02370	COG0583	DNA-binding transcription factor activity
SH_RS02380	COG1380	Effector of murein hydrolase LrgA
SH_RS02385	COG1346	cytolysis
SH_RS02390	COG0028	Belongs to the TPP enzyme family
SH_RS02400	COG2190	(PTS) system
SH_RS02400	COG1263	PTS System
SH_RS02400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS02405	COG1063	alcohol dehydrogenase
SH_RS02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SH_RS02420	COG0039	L-malate dehydrogenase activity
SH_RS02430	COG0697	spore germination
SH_RS02435	COG2207	Transcriptional regulator
SH_RS02435	COG1917	Cupin 2, conserved barrel domain protein
SH_RS02445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SH_RS02465	COG1070	Carbohydrate kinase
SH_RS02475	COG1760	l-serine dehydratase
SH_RS02480	COG1760	l-serine dehydratase
SH_RS02495	COG3764	Sortase (surface protein transpeptidase)
SH_RS02510	COG0778	Nitroreductase
SH_RS02515	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS02525	COG2514	catechol 2,3-dioxygenase activity
SH_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS02545	COG1846	Transcriptional regulator
SH_RS02550	COG0346	lactoylglutathione lyase activity
SH_RS02555	COG0346	lactoylglutathione lyase activity
SH_RS02560	COG0400	carboxylic ester hydrolase activity
SH_RS02565	COG3949	Membrane
SH_RS02575	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SH_RS02580	COG0586	Pfam SNARE associated Golgi protein
SH_RS02590	COG2022	thiamine diphosphate biosynthetic process
SH_RS02595	COG2104	thiamine diphosphate biosynthetic process
SH_RS02595	COG2022	thiamine diphosphate biosynthetic process
SH_RS02600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SH_RS02610	COG2271	Major facilitator Superfamily
SH_RS02625	COG4876	unkown
SH_RS02630	COG2357	RelA SpoT domain protein
SH_RS02645	COG1802	Transcriptional regulator
SH_RS02650	COG1070	Carbohydrate kinase
SH_RS02655	COG2610	gluconate transmembrane transporter activity
SH_RS02665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SH_RS02695	COG4221	oxidoreductase activity
SH_RS02700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH_RS02705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SH_RS02715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SH_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS02725	COG1363	Peptidase, m42
SH_RS02740	COG0069	glutamate synthase activity
SH_RS02755	COG4619	ABC transporter
SH_RS02760	COG0390	transport system, permease component
SH_RS02765	COG2205	protein histidine kinase activity
SH_RS02770	COG0745	RESPONSE REGULATOR receiver
SH_RS02780	COG2814	Major facilitator Superfamily
SH_RS02785	COG2272	Belongs to the type-B carboxylesterase lipase family
SH_RS02790	COG0531	amino acid
SH_RS02795	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SH_RS02800	COG1063	alcohol dehydrogenase
SH_RS02820	COG1174	glycine betaine transport
SH_RS02825	COG1346	cytolysis
SH_RS02830	COG1380	Effector of murein hydrolase LrgA
SH_RS02835	COG3279	Response regulator of the LytR AlgR family
SH_RS02840	COG3275	phosphorelay sensor kinase activity
SH_RS02850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SH_RS02855	COG3477	response to acidic pH
SH_RS02865	COG0706	membrane insertase activity
SH_RS02875	COG0531	amino acid
SH_RS02885	COG1113	amino acid transport
SH_RS02905	COG2226	methyltransferase
SH_RS02910	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SH_RS02915	COG2814	Major facilitator Superfamily
SH_RS02925	COG1929	Belongs to the glycerate kinase type-1 family
SH_RS02940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SH_RS02945	COG0741	lytic transglycosylase activity
SH_RS02950	COG0588	phosphoglycerate mutase activity
SH_RS02955	COG2814	Major facilitator Superfamily
SH_RS02960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH_RS02965	COG0765	amino acid transport
SH_RS02970	COG1126	abc transporter atp-binding protein
SH_RS02990	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH_RS02990	COG3443	Belongs to the bacterial solute-binding protein 9 family
SH_RS02995	COG2353	YceI-like domain
SH_RS03020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SH_RS03025	COG2146	nitrite reductase [NAD(P)H] activity
SH_RS03035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SH_RS03040	COG1140	nitrate reductase beta subunit
SH_RS03045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SH_RS03050	COG2181	nitrate reductase activity
SH_RS03060	COG4585	Histidine kinase
SH_RS03065	COG2197	response regulator
SH_RS03070	COG2223	nitrite transmembrane transporter activity
SH_RS03080	COG1846	Transcriptional regulator
SH_RS03100	COG3871	stress protein (general stress protein 26)
SH_RS03115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS03115	COG1263	PTS System
SH_RS03130	COG1511	domain protein
SH_RS03160	COG0492	ferredoxin-NADP+ reductase activity
SH_RS03170	COG0604	alcohol dehydrogenase
SH_RS03175	COG2822	iron ion transport
SH_RS03180	COG2837	iron assimilation
SH_RS03185	COG0672	)-iron permease
SH_RS03190	COG0805	protein transport
SH_RS03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SH_RS03205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH_RS03205	COG0463	Glycosyl transferase, family 2
SH_RS03210	COG1620	l-lactate permease
SH_RS03215	COG0438	transferase activity, transferring glycosyl groups
SH_RS03220	COG0579	oxidoreductase
SH_RS03235	COG3850	Histidine kinase
SH_RS03235	COG5002	protein histidine kinase activity
SH_RS03240	COG0745	RESPONSE REGULATOR receiver
SH_RS03245	COG0577	efflux transmembrane transporter activity
SH_RS03250	COG1136	(ABC) transporter
SH_RS03265	COG4640	response to antibiotic
SH_RS03270	COG2814	Major facilitator Superfamily
SH_RS03280	COG1566	PFAM secretion protein HlyD family protein
SH_RS03285	COG2814	Major facilitator Superfamily
SH_RS03310	COG0598	Magnesium transport protein CorA
SH_RS03315	COG1304	FMN binding
SH_RS03320	COG0786	glutamate:sodium symporter activity
SH_RS03325	COG2094	Belongs to the DNA glycosylase MPG family
SH_RS03340	COG1742	UPF0060 membrane protein
SH_RS03350	COG2258	MOSC domain
SH_RS03355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SH_RS03365	COG1266	CAAX protease self-immunity
SH_RS03370	COG0010	Belongs to the arginase family
SH_RS03380	COG1473	amidohydrolase
SH_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS03390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SH_RS03405	COG1737	Transcriptional regulator
SH_RS03410	COG1263	PTS System
SH_RS03410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS03420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH_RS03440	COG1113	amino acid transport
SH_RS03450	COG1263	PTS System
SH_RS03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS03455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SH_RS03470	COG2378	regulation of single-species biofilm formation
SH_RS03480	COG1316	TRANSCRIPTIONal
SH_RS03485	COG3383	formate dehydrogenase (NAD+) activity
SH_RS03490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SH_RS03510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH_RS03515	COG2076	Multidrug Resistance protein
SH_RS03520	COG2076	Multidrug Resistance protein
SH_RS03525	COG3942	CHAP domain
SH_RS03540	COG1757	Na H antiporter
SH_RS03555	COG3942	CHAP domain
SH_RS03580	COG1960	acyl-CoA dehydrogenase activity
SH_RS03585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH_RS03590	COG1957	nucleoside hydrolase
SH_RS03595	COG1268	BioY protein
SH_RS03605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SH_RS03610	COG0725	ABC transporter, periplasmic molybdate-binding protein
SH_RS03615	COG4149	molybdate abc transporter
SH_RS03620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SH_RS03625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SH_RS03635	COG0315	cyclic pyranopterin monophosphate synthase activity
SH_RS03660	COG0746	molybdenum cofactor guanylyltransferase activity
SH_RS03665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SH_RS03690	COG2348	transferase activity, transferring amino-acyl groups
SH_RS03695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH_RS03715	COG4975	Glucose uptake
SH_RS03725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SH_RS03725	COG0551	DNA topoisomerase type I activity
SH_RS03730	COG2252	PERMEase
SH_RS03740	COG0051	transcription antitermination factor activity, RNA binding
SH_RS03745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SH_RS03750	COG0088	Forms part of the polypeptide exit tunnel
SH_RS03755	COG0089	rRNA binding
SH_RS03760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SH_RS03765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SH_RS03770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SH_RS03775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SH_RS03780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SH_RS03785	COG0255	Belongs to the universal ribosomal protein uL29 family
SH_RS03790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SH_RS03795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SH_RS03800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SH_RS03805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SH_RS03815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SH_RS03820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SH_RS03825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SH_RS03830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SH_RS03835	COG1841	ribosomal large subunit assembly
SH_RS03840	COG0200	Binds to the 23S rRNA
SH_RS03845	COG0201	protein transport
SH_RS03850	COG0563	adenylate kinase activity
SH_RS03855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SH_RS03860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SH_RS03865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SH_RS03875	COG0202	RNA polymerase activity
SH_RS03880	COG0203	ribosomal protein L17
SH_RS03890	COG1122	ATPase activity
SH_RS03895	COG1122	ATPase activity
SH_RS03905	COG0101	tRNA pseudouridine synthase activity
SH_RS03910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SH_RS03915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SH_RS03920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SH_RS03925	COG1349	DNA-binding transcription factor activity
SH_RS03935	COG0698	ribose 5-phosphate isomerase
SH_RS03940	COG0698	ribose 5-phosphate isomerase
SH_RS03945	COG1105	Belongs to the carbohydrate kinase PfkB family
SH_RS03950	COG3684	Belongs to the aldolase LacD family
SH_RS03955	COG1447	Phosphotransferase system cellobiose-specific component IIA
SH_RS03960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH_RS03960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH_RS03965	COG2723	6-phospho-beta-galactosidase activity
SH_RS03975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SH_RS03980	COG0604	alcohol dehydrogenase
SH_RS03985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SH_RS04000	COG1302	Protein conserved in bacteria
SH_RS04010	COG4264	IucA IucC family
SH_RS04015	COG2814	Major facilitator Superfamily
SH_RS04025	COG3457	Alanine racemase
SH_RS04030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SH_RS04035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS04040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS04045	COG3314	Sporulation integral membrane protein YlbJ
SH_RS04050	COG2329	Antibiotic biosynthesis monooxygenase
SH_RS04060	COG1988	membrane-bound metal-dependent
SH_RS04065	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SH_RS04070	COG1272	protein, Hemolysin III
SH_RS04085	COG2814	Major facilitator Superfamily
SH_RS04090	COG0489	protein tyrosine kinase activity
SH_RS04145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SH_RS04155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SH_RS04165	COG1119	ATPase activity
SH_RS04170	COG0561	phosphatase activity
SH_RS04195	COG0640	Transcriptional regulator
SH_RS04200	COG0702	epimerase
SH_RS04205	COG1482	cell wall glycoprotein biosynthetic process
SH_RS04225	COG0783	Belongs to the Dps family
SH_RS04230	COG0813	purine-nucleoside phosphorylase activity
SH_RS04235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SH_RS04240	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SH_RS04245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SH_RS04255	COG1854	S-ribosylhomocysteine lyase activity
SH_RS04275	COG5146	pantothenate kinase activity
SH_RS04290	COG0504	CTP synthase activity
SH_RS04300	COG0191	fructose-bisphosphate aldolase activity
SH_RS04305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SH_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS04320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SH_RS04325	COG0254	rRNA binding
SH_RS04330	COG1435	thymidine kinase activity
SH_RS04335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SH_RS04340	COG2890	protein-(glutamine-N5) methyltransferase activity
SH_RS04345	COG0009	L-threonylcarbamoyladenylate synthase
SH_RS04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH_RS04355	COG4475	Protein of unknown function (DUF436)
SH_RS04360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SH_RS04365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SH_RS04370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SH_RS04380	COG0356	it plays a direct role in the translocation of protons across the membrane
SH_RS04385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SH_RS04390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SH_RS04395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SH_RS04400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SH_RS04405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SH_RS04410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SH_RS04415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SH_RS04425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SH_RS04430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SH_RS04440	COG0629	single-stranded DNA binding
SH_RS04445	COG1388	LysM domain
SH_RS04450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SH_RS04460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SH_RS04465	COG0352	thiamine-phosphate diphosphorylase activity
SH_RS04470	COG0706	membrane insertase activity
SH_RS04480	COG1418	mRNA catabolic process
SH_RS04485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH_RS04490	COG1937	Protein conserved in bacteria
SH_RS04505	COG0772	Belongs to the SEDS family
SH_RS04510	COG1181	Belongs to the D-alanine--D-alanine ligase family
SH_RS04515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SH_RS04520	COG0513	Belongs to the DEAD box helicase family
SH_RS04530	COG3428	Bacterial PH domain
SH_RS04535	COG3402	PFAM membrane-flanked domain
SH_RS04540	COG0736	holo-[acyl-carrier-protein] synthase activity
SH_RS04545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SH_RS04555	COG2337	Toxic component of a toxin-antitoxin (TA) module
SH_RS04560	COG2208	phosphoserine phosphatase activity
SH_RS04575	COG1191	sigma factor activity
SH_RS04580	COG2183	response to ionizing radiation
SH_RS04620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SH_RS04625	COG0066	3-isopropylmalate dehydratase activity
SH_RS04630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SH_RS04635	COG0473	3-isopropylmalate dehydrogenase activity
SH_RS04640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SH_RS04645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SH_RS04650	COG0440	acetolactate synthase activity
SH_RS04655	COG0028	Belongs to the TPP enzyme family
SH_RS04660	COG0129	dihydroxy-acid dehydratase activity
SH_RS04665	COG0802	atpase or kinase
SH_RS04670	COG1214	PFAM Peptidase M22, glycoprotease
SH_RS04675	COG0456	acetyltransferase
SH_RS04680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SH_RS04685	COG0488	(ABC) transporter
SH_RS04690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SH_RS04695	COG2391	methyltransferase activity
SH_RS04700	COG0425	Belongs to the sulfur carrier protein TusA family
SH_RS04705	COG0004	ammonium transporteR
SH_RS04710	COG1609	Transcriptional regulator
SH_RS04715	COG1621	beta-fructofuranosidase activity
SH_RS04720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH_RS04725	COG3279	Response regulator of the LytR AlgR family
SH_RS04740	COG4512	PFAM Accessory gene regulator B
SH_RS04765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SH_RS04770	COG0459	protein refolding
SH_RS04775	COG0582	viral genome integration into host DNA
SH_RS04840	COG1725	Transcriptional regulator
SH_RS04855	COG1131	(ABC) transporter
SH_RS04890	COG2706	6-phosphogluconolactonase activity
SH_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
SH_RS04900	COG1227	inorganic diphosphatase activity
SH_RS04905	COG1335	isochorismatase
SH_RS04915	COG1605	Chorismate mutase
SH_RS04915	COG0077	Prephenate dehydratase
SH_RS04925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SH_RS04930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SH_RS04935	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SH_RS04940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SH_RS04945	COG4496	protein, YerC YecD
SH_RS04950	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SH_RS04955	COG0210	DNA helicase
SH_RS04960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SH_RS04965	COG4851	CamS sex pheromone cAM373 precursor
SH_RS04975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SH_RS04980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SH_RS04985	COG0154	amidase activity
SH_RS04990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SH_RS04995	COG1597	lipid kinase activity
SH_RS05000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SH_RS05010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SH_RS05020	COG1528	Iron-storage protein
SH_RS05035	COG4129	membrane
SH_RS05040	COG0024	Methionine aminopeptidase
SH_RS05045	COG4221	oxidoreductase activity
SH_RS05065	COG4585	Histidine kinase
SH_RS05070	COG2197	response regulator
SH_RS05080	COG1295	ribonuclease BN
SH_RS05090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH_RS05095	COG4840	Belongs to the UPF0435 family
SH_RS05100	COG2309	aminopeptidase activity
SH_RS05105	COG1607	acyl-coa hydrolase
SH_RS05115	COG0535	radical SAM domain protein
SH_RS05120	COG0693	protein deglycase activity
SH_RS05125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SH_RS05130	COG2137	regulation of response to DNA damage stimulus
SH_RS05140	COG1134	teichoic acid transport
SH_RS05140	COG1388	LysM domain
SH_RS05155	COG1988	membrane-bound metal-dependent
SH_RS05160	COG1194	a g-specific adenine glycosylase
SH_RS05165	COG3557	Belongs to the UPF0374 family
SH_RS05175	COG4129	membrane
SH_RS05180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SH_RS05185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SH_RS05190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH_RS05205	COG0735	belongs to the Fur family
SH_RS05365	COG0765	amino acid transport
SH_RS05370	COG1126	abc transporter atp-binding protein
SH_RS05375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SH_RS05385	COG0363	glucosamine-6-phosphate deaminase activity
SH_RS05395	COG0114	fumarate hydratase activity
SH_RS05400	COG0564	pseudouridine synthase activity
SH_RS05405	COG4585	Histidine kinase
SH_RS05405	COG2203	Gaf domain
SH_RS05410	COG2197	response regulator
SH_RS05420	COG4399	Belongs to the UPF0754 family
SH_RS05425	COG3679	Belongs to the UPF0342 family
SH_RS05435	COG4717	serine-type aminopeptidase activity
SH_RS05440	COG3481	metal-dependent phosphohydrolase, HD sub domain
SH_RS05445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH_RS05460	COG0537	adenosine 5'-monophosphoramidase activity
SH_RS05465	COG1131	(ABC) transporter
SH_RS05470	COG4473	ABC transporter
SH_RS05480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SH_RS05485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SH_RS05490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SH_RS05540	COG0318	PFAM AMP-dependent synthetase and ligase
SH_RS05550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SH_RS05555	COG0494	nUDIX hydrolase
SH_RS05560	COG1506	peptidase
SH_RS05565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SH_RS05570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SH_RS05580	COG0656	L-ascorbic acid biosynthetic process
SH_RS05585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SH_RS05590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SH_RS05600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH_RS05625	COG3266	domain, Protein
SH_RS05625	COG5632	N-Acetylmuramoyl-L-alanine amidase
SH_RS05625	COG4193	domain, Protein
SH_RS05640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH_RS05640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH_RS05645	COG0307	riboflavin synthase, alpha
SH_RS05650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SH_RS05650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SH_RS05655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SH_RS05660	COG0506	proline dehydrogenase activity
SH_RS05665	COG2267	carboxylic ester hydrolase activity
SH_RS05675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SH_RS05680	COG1242	4 iron, 4 sulfur cluster binding
SH_RS05685	COG2814	Major facilitator Superfamily
SH_RS05690	COG0495	leucyl-tRNA aminoacylation
SH_RS05710	COG2081	HI0933 family
SH_RS05715	COG2244	polysaccharide biosynthetic process
SH_RS05720	COG1187	pseudouridine synthase activity
SH_RS05730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH_RS05740	COG0510	thiamine kinase activity
SH_RS05745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SH_RS05750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SH_RS05760	COG1363	Peptidase, m42
SH_RS05765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SH_RS05770	COG4848	Belongs to the UPF0354 family
SH_RS05775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH_RS05780	COG1674	ftsk spoiiie
SH_RS05785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SH_RS05790	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SH_RS05800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SH_RS05800	COG1605	Chorismate mutase
SH_RS05805	COG1609	Transcriptional regulator
SH_RS05815	COG0454	-acetyltransferase
SH_RS05820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SH_RS05825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SH_RS05835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SH_RS05845	COG0477	Major facilitator Superfamily
SH_RS05855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH_RS05860	COG0204	Acyl-transferase
SH_RS05865	COG1263	PTS System
SH_RS05865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS05875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SH_RS05885	COG1764	response to oxidative stress
SH_RS05890	COG0584	glycerophosphoryl diester phosphodiesterase
SH_RS05900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SH_RS05905	COG1956	GAF domain-containing protein
SH_RS05915	COG1104	cysteine desulfurase activity
SH_RS05920	COG0301	tRNA thio-modification
SH_RS05925	COG0730	response to heat
SH_RS05930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SH_RS05935	COG0827	DNA restriction-modification system
SH_RS05940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SH_RS05945	COG0589	response to stress
SH_RS05950	COG0686	Belongs to the AlaDH PNT family
SH_RS05955	COG0006	proline dipeptidase activity
SH_RS05960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SH_RS05970	COG4109	DRTGG domain
SH_RS05975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SH_RS05980	COG0587	DNA-directed DNA polymerase activity
SH_RS05985	COG0281	malic enzyme
SH_RS05990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SH_RS05995	COG0825	malonyl-CoA metabolic process
SH_RS06000	COG0205	6-phosphofructokinase activity
SH_RS06005	COG0469	pyruvate kinase activity
SH_RS06015	COG1113	amino acid transport
SH_RS06020	COG0372	Belongs to the citrate synthase family
SH_RS06025	COG0538	isocitrate dehydrogenase activity
SH_RS06030	COG0745	RESPONSE REGULATOR receiver
SH_RS06035	COG5002	protein histidine kinase activity
SH_RS06040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH_RS06040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH_RS06050	COG0237	dephospho-CoA kinase activity
SH_RS06055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SH_RS06060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SH_RS06070	COG1484	DNA-dependent DNA replication
SH_RS06075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SH_RS06080	COG0833	amino acid
SH_RS06085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SH_RS06090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SH_RS06095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SH_RS06100	COG4112	unkown
SH_RS06110	COG0544	peptidyl-prolyl cis-trans isomerase activity
SH_RS06115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SH_RS06130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SH_RS06135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SH_RS06140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SH_RS06145	COG0181	hydroxymethylbilane synthase activity
SH_RS06160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SH_RS06170	COG2818	Glycosylase
SH_RS06175	COG0525	valine-tRNA ligase activity
SH_RS06180	COG0285	dihydrofolate synthase activity
SH_RS06185	COG2003	Belongs to the UPF0758 family
SH_RS06205	COG1792	Involved in formation and maintenance of cell shape
SH_RS06215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SH_RS06220	COG2868	ribosomal protein
SH_RS06225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SH_RS06230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SH_RS06235	COG4492	Belongs to the UPF0735 family
SH_RS06240	COG0632	four-way junction helicase activity
SH_RS06245	COG2255	four-way junction helicase activity
SH_RS06250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SH_RS06255	COG0343	queuine tRNA-ribosyltransferase activity
SH_RS06260	COG1862	Preprotein translocase
SH_RS06265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SH_RS06265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SH_RS06270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SH_RS06270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SH_RS06275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH_RS06280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SH_RS06285	COG1490	D-aminoacyl-tRNA deacylase activity
SH_RS06290	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH_RS06295	COG0124	histidyl-tRNA synthetase
SH_RS06300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SH_RS06305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SH_RS06310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SH_RS06315	COG1959	2 iron, 2 sulfur cluster binding
SH_RS06320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SH_RS06325	COG1104	cysteine desulfurase activity
SH_RS06330	COG0482	sulfurtransferase activity
SH_RS06340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SH_RS06345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SH_RS06350	COG4472	Bacterial protein of unknown function (DUF965)
SH_RS06355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SH_RS06360	COG3906	Belongs to the UPF0473 family
SH_RS06370	COG0826	peptidase U32
SH_RS06375	COG0826	peptidase U32
SH_RS06380	COG0572	uridine kinase
SH_RS06385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH_RS06390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SH_RS06395	COG1984	allophanate hydrolase subunit 2
SH_RS06400	COG0511	ligase activity, forming carbon-carbon bonds
SH_RS06405	COG0439	Biotin carboxylase
SH_RS06410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SH_RS06415	COG1914	H( )-stimulated, divalent metal cation uptake system
SH_RS06420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SH_RS06425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SH_RS06430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SH_RS06435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SH_RS06440	COG1534	Rna-binding protein
SH_RS06445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SH_RS06450	COG1713	HD superfamily hydrolase involved in NAD metabolism
SH_RS06455	COG0799	negative regulation of ribosome biogenesis
SH_RS06460	COG2226	methyltransferase
SH_RS06465	COG1596	polysaccharide export
SH_RS06465	COG1555	photosystem II stabilization
SH_RS06470	COG2131	deaminase
SH_RS06475	COG0658	competence protein
SH_RS06475	COG2333	competence protein COMEC
SH_RS06480	COG1466	dna polymerase III delta subunit
SH_RS06490	COG0268	Binds directly to 16S ribosomal RNA
SH_RS06495	COG0481	GTPase activity
SH_RS06500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SH_RS06505	COG1420	regulation of RNA biosynthetic process
SH_RS06510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SH_RS06515	COG0443	Heat shock 70 kDa protein
SH_RS06520	COG0484	heat shock protein binding
SH_RS06525	COG2264	protein methyltransferase activity
SH_RS06530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SH_RS06535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SH_RS06545	COG1030	water channel activity
SH_RS06550	COG4864	UPF0365 protein
SH_RS06560	COG1702	phosphate starvation-inducible protein PhoH
SH_RS06565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SH_RS06570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SH_RS06580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SH_RS06585	COG1381	Involved in DNA repair and RecF pathway recombination
SH_RS06590	COG0423	glycine-tRNA ligase activity
SH_RS06595	COG0517	IMP dehydrogenase activity
SH_RS06600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SH_RS06610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SH_RS06615	COG2384	SAM-dependent methyltransferase
SH_RS06620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SH_RS06625	COG0513	Belongs to the DEAD box helicase family
SH_RS06630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SH_RS06635	COG1121	(ABC) transporter
SH_RS06640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SH_RS06650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SH_RS06655	COG0768	penicillin binding
SH_RS06660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SH_RS06665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SH_RS06675	COG4483	Protein conserved in bacteria
SH_RS06680	COG1940	carbohydrate kinase activity
SH_RS06685	COG0011	TIGRFAM Protein of
SH_RS06690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SH_RS06695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SH_RS06700	COG1459	type II secretion system
SH_RS06705	COG4537	Required for transformation and DNA binding
SH_RS06730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SH_RS06735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SH_RS06740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SH_RS06745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SH_RS06750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SH_RS06755	COG0095	Lipoate-protein ligase
SH_RS06770	COG0006	proline dipeptidase activity
SH_RS06775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SH_RS06780	COG0511	ligase activity, forming carbon-carbon bonds
SH_RS06785	COG0439	Biotin carboxylase
SH_RS06790	COG1302	Protein conserved in bacteria
SH_RS06795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SH_RS06800	COG1570	exodeoxyribonuclease VII activity
SH_RS06805	COG1722	exodeoxyribonuclease VII activity
SH_RS06815	COG1438	arginine binding
SH_RS06820	COG0497	DNA recombination
SH_RS06825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH_RS06830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SH_RS06835	COG0022	dehydrogenase e1 component
SH_RS06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
SH_RS06850	COG4129	membrane
SH_RS06860	COG2195	Cleaves the N-terminal amino acid of tripeptides
SH_RS06870	COG1609	Transcriptional regulator
SH_RS06875	COG0366	Alpha amylase catalytic
SH_RS06885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SH_RS06890	COG1234	tRNA 3'-trailer cleavage
SH_RS06895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SH_RS06900	COG0300	oxidoreductase activity
SH_RS06910	COG0667	Aldo Keto reductase
SH_RS06915	COG0494	nUDIX hydrolase
SH_RS06920	COG0735	belongs to the Fur family
SH_RS06925	COG4974	Belongs to the 'phage' integrase family
SH_RS06935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SH_RS06940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SH_RS06945	COG1187	pseudouridine synthase activity
SH_RS06950	COG0745	RESPONSE REGULATOR receiver
SH_RS06965	COG1141	Ferredoxin
SH_RS06975	COG0514	ATP-dependent DNA helicase (RecQ)
SH_RS06980	COG1388	LysM domain
SH_RS06985	COG0492	ferredoxin-NADP+ reductase activity
SH_RS06995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SH_RS07000	COG0539	negative regulation of cytoplasmic translation
SH_RS07005	COG1160	GTP binding
SH_RS07010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SH_RS07030	COG2226	methyltransferase
SH_RS07035	COG0142	geranyltranstransferase activity
SH_RS07040	COG0105	UTP biosynthetic process
SH_RS07045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SH_RS07050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SH_RS07055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SH_RS07060	COG0457	Tetratricopeptide repeat
SH_RS07065	COG5582	Belongs to the UPF0302 family
SH_RS07070	COG4347	Protein of unknown function (DUF1405)
SH_RS07075	COG2738	Putative neutral zinc metallopeptidase
SH_RS07080	COG1694	Mazg nucleotide pyrophosphohydrolase
SH_RS07085	COG0438	transferase activity, transferring glycosyl groups
SH_RS07090	COG0617	tRNA 3'-terminal CCA addition
SH_RS07100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH_RS07100	COG1199	ATP-dependent helicase activity
SH_RS07105	COG0017	Asparaginyl-tRNA synthetase
SH_RS07110	COG3935	DnaD domain protein
SH_RS07115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SH_RS07125	COG4499	WXG100 protein secretion system (Wss), protein YukC
SH_RS07125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SH_RS07130	COG3331	DNA recombination
SH_RS07140	COG4474	Belongs to the UPF0398 family
SH_RS07145	COG3599	regulation of cell shape
SH_RS07150	COG0116	Belongs to the methyltransferase superfamily
SH_RS07160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SH_RS07165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH_RS07185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SH_RS07190	COG1413	lyase activity
SH_RS07195	COG1413	lyase activity
SH_RS07205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SH_RS07225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SH_RS07230	COG2190	(PTS) system
SH_RS07235	COG4479	Belongs to the UPF0346 family
SH_RS07240	COG0793	Belongs to the peptidase S41A family
SH_RS07250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SH_RS07255	COG0671	phosphoesterase, PA-phosphatase related
SH_RS07260	COG0745	RESPONSE REGULATOR receiver
SH_RS07265	COG5002	protein histidine kinase activity
SH_RS07270	COG0567	Dehydrogenase, E1 component
SH_RS07275	COG0508	dehydrogenase complex catalyzes the overall conversion of
SH_RS07300	COG0714	Associated with various cellular activities
SH_RS07305	COG4548	von Willebrand factor, type A
SH_RS07310	COG1114	Component of the transport system for branched-chain amino acids
SH_RS07320	COG3853	Toxic anion resistance protein (TelA)
SH_RS07330	COG1254	Belongs to the acylphosphatase family
SH_RS07340	COG1278	Cold shock
SH_RS07360	COG1473	amidohydrolase
SH_RS07365	COG2171	N-acyltransferase activity
SH_RS07370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SH_RS07375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SH_RS07380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SH_RS07390	COG0488	(ABC) transporter
SH_RS07395	COG2996	Protein conserved in bacteria
SH_RS07400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SH_RS07405	COG0573	inorganic phosphate transmembrane transporter activity
SH_RS07410	COG0581	inorganic phosphate transmembrane transporter activity
SH_RS07415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SH_RS07420	COG0704	Plays a role in the regulation of phosphate uptake
SH_RS07425	COG1164	Oligoendopeptidase f
SH_RS07435	COG4607	ABC-type enterochelin transport system periplasmic component
SH_RS07440	COG0561	phosphatase activity
SH_RS07445	COG2348	transferase activity, transferring amino-acyl groups
SH_RS07450	COG2348	transferase activity, transferring amino-acyl groups
SH_RS07465	COG0159	tryptophan synthase activity
SH_RS07475	COG0135	phosphoribosylanthranilate isomerase activity
SH_RS07480	COG0134	indole-3-glycerol-phosphate synthase activity
SH_RS07485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH_RS07490	COG0512	Glutamine amidotransferase of anthranilate synthase
SH_RS07495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SH_RS07500	COG1363	Peptidase, m42
SH_RS07505	COG0287	Prephenate dehydrogenase
SH_RS07510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SH_RS07515	COG1942	4-Oxalocrotonate Tautomerase
SH_RS07530	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SH_RS07530	COG0392	lysyltransferase activity
SH_RS07535	COG0628	permease
SH_RS07540	COG3711	transcriptional antiterminator
SH_RS07545	COG1115	amino acid carrier protein
SH_RS07550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SH_RS07555	COG0187	DNA topoisomerase II activity
SH_RS07560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SH_RS07565	COG4841	protein insertion into membrane
SH_RS07570	COG0824	Thioesterase
SH_RS07575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SH_RS07580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SH_RS07585	COG1970	mechanosensitive ion channel activity
SH_RS07590	COG0419	ATPase involved in DNA repair
SH_RS07595	COG0420	3'-5' exonuclease activity
SH_RS07600	COG4846	Membrane protein involved in cytochrome C biogenesis
SH_RS07615	COG4224	UPF0291 protein
SH_RS07625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SH_RS07630	COG2340	Cysteine-rich secretory protein family
SH_RS07635	COG0516	GMP reductase activity
SH_RS07640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SH_RS07650	COG0753	catalase activity
SH_RS07655	COG0833	amino acid
SH_RS07670	COG0083	homoserine kinase activity
SH_RS07675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SH_RS07680	COG0460	homoserine dehydrogenase
SH_RS07685	COG0527	aspartate kinase activity
SH_RS07715	COG2197	response regulator
SH_RS07720	COG4585	Histidine kinase
SH_RS07730	COG1131	(ABC) transporter
SH_RS07735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH_RS07790	COG0789	Transcriptional regulator
SH_RS07795	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SH_RS07800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SH_RS07805	COG0386	Belongs to the glutathione peroxidase family
SH_RS07810	COG1923	regulation of RNA biosynthetic process
SH_RS07815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SH_RS07825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SH_RS07830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SH_RS07845	COG0456	acetyltransferase
SH_RS07855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH_RS07865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SH_RS07870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SH_RS07880	COG4550	Control of competence regulator ComK, YlbF/YmcA
SH_RS07885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SH_RS07895	COG4195	phage-related replication protein
SH_RS07900	COG1013	pyruvate-flavodoxin oxidoreductase activity
SH_RS07905	COG0674	pyruvate-flavodoxin oxidoreductase activity
SH_RS07905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SH_RS07910	COG1692	metallophosphoesterase
SH_RS07920	COG1418	mRNA catabolic process
SH_RS07925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SH_RS07930	COG1546	Belongs to the CinA family
SH_RS07930	COG1058	Belongs to the CinA family
SH_RS07950	COG0300	oxidoreductase activity
SH_RS07955	COG0612	Peptidase, M16
SH_RS07960	COG0612	Peptidase, M16
SH_RS07965	COG2188	Transcriptional regulator
SH_RS07970	COG1674	ftsk spoiiie
SH_RS07975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SH_RS07980	COG1185	polyribonucleotide nucleotidyltransferase activity
SH_RS07985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SH_RS07990	COG0196	riboflavin kinase activity
SH_RS07995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SH_RS08005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SH_RS08010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SH_RS08015	COG1358	cellular component organization or biogenesis
SH_RS08020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SH_RS08025	COG0195	Participates in both transcription termination and antitermination
SH_RS08030	COG0779	Required for maturation of 30S ribosomal subunits
SH_RS08035	COG2176	DNA-directed DNA polymerase activity
SH_RS08040	COG0442	prolyl-tRNA aminoacylation
SH_RS08050	COG4589	Belongs to the CDS family
SH_RS08055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SH_RS08060	COG0233	cytoplasmic translational termination
SH_RS08065	COG0528	UMP kinase activity
SH_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SH_RS08075	COG0052	Belongs to the universal ribosomal protein uS2 family
SH_RS08080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SH_RS08085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SH_RS08090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SH_RS08095	COG4974	Belongs to the 'phage' integrase family
SH_RS08100	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SH_RS08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SH_RS08110	COG0758	DNA mediated transformation
SH_RS08120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SH_RS08125	COG0045	succinate-CoA ligase (ADP-forming) activity
SH_RS08130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SH_RS08140	COG4485	Bacterial membrane protein, YfhO
SH_RS08150	COG0335	large ribosomal subunit rRNA binding
SH_RS08155	COG0336	Belongs to the RNA methyltransferase TrmD family
SH_RS08160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SH_RS08165	COG0228	four-way junction DNA binding
SH_RS08170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SH_RS08175	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SH_RS08180	COG0552	protein localization to endoplasmic reticulum
SH_RS08185	COG1196	nuclear chromosome segregation
SH_RS08190	COG0571	ribonuclease III activity
SH_RS08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS08210	COG0416	fatty acid biosynthetic process
SH_RS08215	COG1349	DNA-binding transcription factor activity
SH_RS08230	COG1461	Dihydroxyacetone kinase
SH_RS08235	COG1302	Protein conserved in bacteria
SH_RS08240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SH_RS08245	COG1564	THIamine pyrophosphokinase
SH_RS08250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SH_RS08255	COG1162	GTPase activity
SH_RS08265	COG0631	protein serine/threonine phosphatase activity
SH_RS08270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SH_RS08275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SH_RS08275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SH_RS08280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SH_RS08295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SH_RS08300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SH_RS08305	COG1758	RNA polymerase activity
SH_RS08310	COG0194	GDP metabolic process
SH_RS08330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SH_RS08335	COG0284	orotidine-5'-phosphate decarboxylase activity
SH_RS08340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SH_RS08345	COG0505	Belongs to the CarA family
SH_RS08355	COG0540	Belongs to the ATCase OTCase family
SH_RS08360	COG2233	PERMEase
SH_RS08365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SH_RS08370	COG0564	pseudouridine synthase activity
SH_RS08375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SH_RS08380	COG3942	CHAP domain
SH_RS08380	COG1388	LysM domain
SH_RS08390	COG0702	epimerase
SH_RS08395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SH_RS08400	COG3599	regulation of cell shape
SH_RS08410	COG0762	integral membrane protein
SH_RS08415	COG1799	cell septum assembly
SH_RS08420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SH_RS08425	COG1496	oxidoreductase activity
SH_RS08430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SH_RS08435	COG0849	cell division
SH_RS08440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SH_RS08445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SH_RS08450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SH_RS08455	COG0768	penicillin binding
SH_RS08460	COG4839	cell division protein FtsL
SH_RS08465	COG0275	rRNA processing
SH_RS08470	COG2001	Belongs to the MraZ family
SH_RS08475	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SH_RS08480	COG0454	-acetyltransferase
SH_RS08485	COG1011	Hydrolase
SH_RS08530	COG1388	LysM domain
SH_RS08530	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH_RS08610	COG3682	Transcriptional regulator
SH_RS08685	COG3677	Transposase
SH_RS08790	COG3561	AntA/AntB antirepressor
SH_RS08800	COG1396	sequence-specific DNA binding
SH_RS08815	COG0582	viral genome integration into host DNA
SH_RS08825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SH_RS08830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SH_RS08835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SH_RS08840	COG1053	succinate dehydrogenase
SH_RS08845	COG2009	succinate dehydrogenase
SH_RS08850	COG0322	excinuclease ABC activity
SH_RS08855	COG3118	belongs to the thioredoxin family
SH_RS08860	COG1193	negative regulation of DNA recombination
SH_RS08865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SH_RS08865	COG1796	DNA polymerase
SH_RS08875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SH_RS08880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SH_RS08885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH_RS08885	COG0072	phenylalanine-tRNA ligase activity
SH_RS08890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SH_RS08895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH_RS08900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SH_RS08910	COG1323	Belongs to the UPF0348 family
SH_RS08915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SH_RS08920	COG0742	ribosomal rna small subunit methyltransferase
SH_RS08930	COG4471	UPF0298 protein
SH_RS08940	COG3679	Belongs to the UPF0342 family
SH_RS08945	COG2340	Cysteine-rich secretory protein family
SH_RS08955	COG0109	protoheme IX farnesyltransferase activity
SH_RS08960	COG1612	heme a metabolic process
SH_RS08970	COG0772	Belongs to the SEDS family
SH_RS08975	COG4838	Belongs to the UPF0358 family
SH_RS08980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SH_RS08985	COG4896	Protein conserved in bacteria
SH_RS08990	COG1217	gtp-binding protein TYPA
SH_RS09000	COG0483	inositol monophosphate 1-phosphatase activity
SH_RS09005	COG4493	Belongs to the UPF0637 family
SH_RS09010	COG1914	H( )-stimulated, divalent metal cation uptake system
SH_RS09030	COG1177	transmembrane transport
SH_RS09035	COG1176	ABC-type spermidine putrescine transport system, permease component I
SH_RS09040	COG3842	ATPase activity
SH_RS09045	COG1396	sequence-specific DNA binding
SH_RS09045	COG3800	Transcriptional regulator
SH_RS09050	COG4476	Belongs to the UPF0223 family
SH_RS09080	COG0242	peptide deformylase activity
SH_RS09085	COG5503	Protein of unknown function (DUF1447)
SH_RS09090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SH_RS09100	COG2832	Protein of unknown function (DUF454)
SH_RS09105	COG0569	domain protein
SH_RS09110	COG1294	oxidase, subunit
SH_RS09115	COG1271	oxidase subunit
SH_RS09130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH_RS09145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SH_RS09160	COG1122	ATPase activity
SH_RS09165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SH_RS09170	COG0151	Belongs to the GarS family
SH_RS09175	COG0138	bifunctional purine biosynthesis protein purh
SH_RS09185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SH_RS09195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SH_RS09200	COG0047	phosphoribosylformylglycinamidine synthase activity
SH_RS09205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SH_RS09210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SH_RS09215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SH_RS09220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SH_RS09225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SH_RS09250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SH_RS09255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SH_RS09260	COG1845	cytochrome c oxidase, subunit III
SH_RS09265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SH_RS09280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH_RS09285	COG1316	TRANSCRIPTIONal
SH_RS09320	COG3594	Acyltransferase
SH_RS09325	COG0436	Aminotransferase
SH_RS09330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SH_RS09335	COG0596	Alpha beta hydrolase
SH_RS09340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SH_RS09345	COG1169	isochorismate synthase
SH_RS09350	COG1575	Belongs to the MenA family. Type 1 subfamily
SH_RS09415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SH_RS09420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH_RS09425	COG0861	Integral membrane protein TerC family
SH_RS09430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SH_RS09440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SH_RS09445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SH_RS09450	COG2814	Major facilitator Superfamily
SH_RS09455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SH_RS09460	COG2382	esterase
SH_RS09465	COG0628	permease
SH_RS09475	COG0569	domain protein
SH_RS09475	COG0475	glutathione-regulated potassium exporter activity
SH_RS09480	COG2239	Acts as a magnesium transporter
SH_RS09485	COG0564	pseudouridine synthase activity
SH_RS09490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SH_RS09495	COG2357	RelA SpoT domain protein
SH_RS09505	COG4116	CYTH
SH_RS09510	COG2346	COG2346, Truncated hemoglobins
SH_RS09515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SH_RS09520	COG1164	Oligoendopeptidase f
SH_RS09535	COG4862	establishment of competence for transformation
SH_RS09540	COG1393	Belongs to the ArsC family
SH_RS09545	COG0180	Tryptophanyl-tRNA synthetase
SH_RS09560	COG4166	transmembrane transport
SH_RS09565	COG4608	Belongs to the ABC transporter superfamily
SH_RS09570	COG0444	Belongs to the ABC transporter superfamily
SH_RS09575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH_RS09580	COG0601	transmembrane transport
SH_RS09595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SH_RS09605	COG0542	response to heat
SH_RS09620	COG0561	phosphatase activity
SH_RS09625	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH_RS09635	COG0179	Fumarylacetoacetate (FAA) hydrolase
SH_RS09640	COG1074	ATP-dependent DNA helicase activity
SH_RS09645	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SH_RS09660	COG0398	Pfam SNARE associated Golgi protein
SH_RS09665	COG0166	Belongs to the GPI family
SH_RS09670	COG0137	argininosuccinate synthase activity
SH_RS09675	COG0165	Argininosuccinate lyase
SH_RS09680	COG0584	glycerophosphoryl diester phosphodiesterase
SH_RS09695	COG1902	pentaerythritol trinitrate reductase activity
SH_RS09700	COG1098	S1 RNA binding domain
SH_RS09705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SH_RS09715	COG2111	Na H antiporter
SH_RS09715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SH_RS09720	COG2111	Na H antiporter
SH_RS09725	COG1006	Multisubunit Na H antiporter MnhC subunit
SH_RS09730	COG0651	ATP synthesis coupled electron transport
SH_RS09735	COG1863	multisubunit Na H antiporter MnhE subunit
SH_RS09740	COG2212	antiporter activity
SH_RS09745	COG1320	monovalent cation:proton antiporter activity
SH_RS09755	COG2050	protein possibly involved in aromatic compounds catabolism
SH_RS09760	COG2056	Na+-H+ antiporter family
SH_RS09765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SH_RS09770	COG1252	NADH dehydrogenase
SH_RS09775	COG0316	Belongs to the HesB IscA family
SH_RS09780	COG4844	belongs to the
SH_RS09785	COG1252	NADH dehydrogenase
SH_RS09790	COG4837	Protein of unknown function (DUF1462)
SH_RS09795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SH_RS09805	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SH_RS09810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH_RS09815	COG1696	Membrane protein involved in D-alanine export
SH_RS09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SH_RS09835	COG0647	UMP catabolic process
SH_RS09840	COG2445	Protein of unknown function DUF86
SH_RS09850	COG4470	Protein conserved in bacteria
SH_RS09855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SH_RS09860	COG0737	Belongs to the 5'-nucleotidase family
SH_RS09865	COG0730	response to heat
SH_RS09870	COG1801	Protein of unknown function DUF72
SH_RS09875	COG2070	2-Nitropropane dioxygenase
SH_RS09890	COG0719	Fe-S assembly protein
SH_RS09895	COG0822	iron-sulfur transferase activity
SH_RS09905	COG0719	Fe-S assembly protein
SH_RS09910	COG0396	ATPase activity
SH_RS09925	COG3237	CsbD-like
SH_RS09930	COG1464	Belongs to the NlpA lipoprotein family
SH_RS09935	COG2011	ABC-type metal ion transport system permease component
SH_RS09940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SH_RS09950	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SH_RS09955	COG0509	glycine decarboxylation via glycine cleavage system
SH_RS09960	COG1393	Belongs to the ArsC family
SH_RS09965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SH_RS09975	COG0710	3-dehydroquinate dehydratase activity
SH_RS09980	COG1764	response to oxidative stress
SH_RS09990	COG1279	arginine transmembrane transporter activity
SH_RS09995	COG0406	alpha-ribazole phosphatase activity
SH_RS10040	COG0456	acetyltransferase
SH_RS10045	COG4195	phage-related replication protein
SH_RS10195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SH_RS10200	COG0557	exoribonuclease II activity
SH_RS10205	COG1647	Serine aminopeptidase, S33
SH_RS10210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SH_RS10220	COG0148	phosphopyruvate hydratase activity
SH_RS10225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SH_RS10230	COG0149	triose-phosphate isomerase activity
SH_RS10235	COG0126	phosphoglycerate kinase activity
SH_RS10245	COG2390	Transcriptional regulator
SH_RS10265	COG1090	epimerase
SH_RS10270	COG0740	serine-type endopeptidase activity
SH_RS10280	COG1481	regulation of sporulation
SH_RS10285	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SH_RS10290	COG1660	Displays ATPase and GTPase activities
SH_RS10295	COG0492	ferredoxin-NADP+ reductase activity
SH_RS10310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SH_RS10315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SH_RS10320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SH_RS10325	COG0556	nucleotide-excision repair
SH_RS10345	COG3942	CHAP domain
SH_RS10345	COG1388	LysM domain
SH_RS10350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SH_RS10355	COG0653	protein targeting
SH_RS10360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SH_RS10365	COG1040	competence protein
SH_RS10370	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SH_RS10380	COG1739	Uncharacterized protein family UPF0029
SH_RS10385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SH_RS10390	COG2199	diguanylate cyclase activity
SH_RS10405	COG2195	Cleaves the N-terminal amino acid of tripeptides
SH_RS10410	COG1929	Belongs to the glycerate kinase type-1 family
SH_RS10430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SH_RS10445	COG4607	ABC-type enterochelin transport system periplasmic component
SH_RS10450	COG4604	ABC transporter, ATP-binding protein
SH_RS10455	COG4605	iron ion homeostasis
SH_RS10460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS10465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH_RS10470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH_RS10475	COG1780	Probably involved in ribonucleotide reductase function
SH_RS10485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SH_RS10490	COG3104	oligopeptide transport
SH_RS10495	COG1597	lipid kinase activity
SH_RS10505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SH_RS10510	COG3104	oligopeptide transport
SH_RS10515	COG1174	glycine betaine transport
SH_RS10525	COG0514	ATP-dependent DNA helicase (RecQ)
SH_RS10530	COG0488	(ABC) transporter
SH_RS10550	COG1368	sulfuric ester hydrolase activity
SH_RS10555	COG1984	allophanate hydrolase subunit 2
SH_RS10560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SH_RS10580	COG0512	Glutamine amidotransferase of anthranilate synthase
SH_RS10580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH_RS10585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SH_RS10590	COG0720	synthase
SH_RS10595	COG0602	queuosine metabolic process
SH_RS10605	COG0463	Glycosyl transferase, family 2
SH_RS10615	COG0656	L-ascorbic acid biosynthetic process
SH_RS10620	COG1253	flavin adenine dinucleotide binding
SH_RS10625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH_RS10625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH_RS10625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH_RS10630	COG1105	Belongs to the carbohydrate kinase PfkB family
SH_RS10635	COG1349	DNA-binding transcription factor activity
SH_RS10640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SH_RS10670	COG0415	Belongs to the DNA photolyase family
SH_RS10675	COG0471	metal ion transport
SH_RS10685	COG0523	cobalamin synthesis protein
SH_RS10695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SH_RS10700	COG4988	ABC transporter
SH_RS10705	COG1968	undecaprenyl-diphosphatase activity
SH_RS10715	COG1671	Belongs to the UPF0178 family
SH_RS10720	COG1611	Belongs to the LOG family
SH_RS10725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH_RS10740	COG0456	acetyltransferase
SH_RS10750	COG2839	Protein conserved in bacteria
SH_RS10760	COG0583	DNA-binding transcription factor activity
SH_RS10770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SH_RS10780	COG0217	transcriptional regulatory protein
SH_RS10800	COG3942	CHAP domain
SH_RS10800	COG1388	LysM domain
SH_RS10805	COG0306	phosphate transporter
SH_RS10810	COG1392	Phosphate transport regulator
SH_RS10815	COG0577	efflux transmembrane transporter activity
SH_RS10820	COG1136	(ABC) transporter
SH_RS10825	COG2205	protein histidine kinase activity
SH_RS10830	COG0745	RESPONSE REGULATOR receiver
SH_RS10835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH_RS10845	COG0657	acetylesterase activity
SH_RS10850	COG3949	Membrane
SH_RS10860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SH_RS10870	COG2376	Dihydroxyacetone kinase
SH_RS10875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS10880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS10885	COG1120	ATPase activity
SH_RS10890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SH_RS10895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH_RS10900	COG0463	Glycosyl transferase, family 2
SH_RS10900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH_RS10910	COG1132	(ABC) transporter
SH_RS10915	COG1686	Belongs to the peptidase S11 family
SH_RS10920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SH_RS10930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH_RS10935	COG1682	transport, permease protein
SH_RS10940	COG1134	teichoic acid transport
SH_RS10945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SH_RS10955	COG1321	iron dependent repressor
SH_RS10985	COG1320	monovalent cation:proton antiporter activity
SH_RS10990	COG2212	antiporter activity
SH_RS10995	COG1863	multisubunit Na H antiporter MnhE subunit
SH_RS11000	COG0651	ATP synthesis coupled electron transport
SH_RS11005	COG1006	Multisubunit Na H antiporter MnhC subunit
SH_RS11010	COG2111	Na H antiporter
SH_RS11015	COG2111	Na H antiporter
SH_RS11015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SH_RS11080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH_RS11085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH_RS11100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SH_RS11105	COG0018	arginyl-trna synthetase
SH_RS11135	COG1131	(ABC) transporter
SH_RS11145	COG3173	Aminoglycoside phosphotransferase
SH_RS11155	COG3226	Transcriptional regulator
SH_RS11180	COG3093	addiction module antidote protein HigA
SH_RS11230	COG1078	dGTPase activity
SH_RS11240	COG0655	NAD(P)H dehydrogenase (quinone) activity
SH_RS11245	COG0667	Aldo Keto reductase
SH_RS11255	COG5632	N-Acetylmuramoyl-L-alanine amidase
SH_RS11255	COG1388	LysM domain
SH_RS11300	COG5434	Belongs to the glycosyl hydrolase 28 family
SH_RS11370	COG2369	cell adhesion
SH_RS11380	COG1783	phage Terminase large subunit
SH_RS11425	COG0756	dUTP diphosphatase activity
SH_RS11480	COG1484	DNA-dependent DNA replication
SH_RS11565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH_RS11570	COG1278	Cold shock
SH_RS11575	COG4844	belongs to the
SH_RS11595	COG0095	Lipoate-protein ligase
SH_RS11605	COG3253	May function as heme-dependent peroxidase
SH_RS11610	COG2966	Psort location CytoplasmicMembrane, score
SH_RS11625	COG2363	Small membrane protein
SH_RS11635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SH_RS11650	COG0477	Major facilitator Superfamily
SH_RS11665	COG0183	Belongs to the thiolase family
SH_RS11670	COG0318	PFAM AMP-dependent synthetase and ligase
SH_RS11675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SH_RS11680	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SH_RS11690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SH_RS11695	COG1469	GTP cyclohydrolase I activity
SH_RS11730	COG0431	NADPH-dependent FMN reductase
SH_RS11735	COG0561	phosphatase activity
SH_RS11745	COG1428	Deoxynucleoside kinase
SH_RS11750	COG1428	Deoxynucleoside kinase
SH_RS11755	COG0546	phosphoglycolate phosphatase activity
SH_RS11765	COG3177	Filamentation induced by cAMP protein fic
SH_RS11800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SH_RS11805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH_RS11810	COG0737	Belongs to the 5'-nucleotidase family
SH_RS11835	COG1473	amidohydrolase
SH_RS11840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SH_RS11845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SH_RS11855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SH_RS11865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SH_RS11870	COG0085	RNA polymerase activity
SH_RS11875	COG2813	Specifically methylates the guanine in position
SH_RS11880	COG0222	ribosome binding
SH_RS11885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SH_RS11895	COG0081	regulation of translation
SH_RS11900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SH_RS11905	COG0250	Participates in transcription elongation, termination and antitermination
SH_RS11910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SH_RS11915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SH_RS11925	COG3688	RNA-binding protein containing a PIN domain
SH_RS11930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH_RS11935	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SH_RS11940	COG0215	cysteine-tRNA ligase activity
SH_RS11945	COG1045	serine acetyltransferase
SH_RS11950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SH_RS11955	COG4956	integral membrane protein (PIN domain superfamily)
SH_RS11960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SH_RS11965	COG0542	response to heat
SH_RS11970	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SH_RS11975	COG3880	PFAM UvrB UvrC protein
SH_RS11980	COG4463	regulation of RNA biosynthetic process
SH_RS11985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH_RS11990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SH_RS11995	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SH_RS12000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH_RS12005	COG2259	Doxx family
SH_RS12075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SH_RS12080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SH_RS12095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SH_RS12100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SH_RS12105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SH_RS12115	COG0037	tRNA processing
SH_RS12120	COG1098	S1 RNA binding domain
SH_RS12130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SH_RS12135	COG3956	TIGRFAM MazG family protein
SH_RS12140	COG2244	polysaccharide biosynthetic process
SH_RS12145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SH_RS12150	COG0193	aminoacyl-tRNA hydrolase activity
SH_RS12155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SH_RS12160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SH_RS12165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SH_RS12170	COG2088	sporulation resulting in formation of a cellular spore
SH_RS12175	COG0251	oxidation-reduction process
SH_RS12180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH_RS12185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SH_RS12190	COG4466	Protein conserved in bacteria
SH_RS12195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SH_RS12200	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SH_RS12205	COG0084	hydrolase, TatD family'
SH_RS12210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH_RS12210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH_RS12215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SH_RS12220	COG2827	Endonuclease containing a URI domain
SH_RS12225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SH_RS12230	COG4467	Involved in initiation control of chromosome replication
SH_RS12235	COG1774	PSP1 C-terminal conserved region
SH_RS12240	COG0470	DNA polymerase III
SH_RS12245	COG3870	Protein conserved in bacteria
SH_RS12250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SH_RS12255	COG1982	Orn Lys Arg decarboxylase major
SH_RS12280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SH_RS12290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SH_RS12300	COG2188	Transcriptional regulator
SH_RS12305	COG0366	Alpha amylase catalytic
SH_RS12310	COG1263	PTS System
SH_RS12310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH_RS12320	COG0493	'glutamate synthase
SH_RS12325	COG0067	glutamate synthase
SH_RS12325	COG0069	glutamate synthase activity
SH_RS12325	COG0070	glutamate synthase
SH_RS12330	COG0583	DNA-binding transcription factor activity
SH_RS12360	COG3942	CHAP domain
SH_RS12360	COG1388	LysM domain
SH_RS12365	COG0626	cystathionine gamma-synthase activity
SH_RS12370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SH_RS12385	COG0733	neurotransmitter:sodium symporter activity
SH_RS12400	COG1647	Serine aminopeptidase, S33
SH_RS12410	COG0671	phosphoesterase, PA-phosphatase related
SH_RS12420	COG5609	conserved protein (DUF2294)
SH_RS12425	COG3002	Belongs to the UPF0753 family
SH_RS12430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SH_RS12435	COG3759	membrane
SH_RS12450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SH_RS12460	COG5484	DNA packaging
SH_RS12460	COG3728	DNA packaging
SH_RS12505	COG0582	viral genome integration into host DNA
SH_RS12510	COG0519	Catalyzes the synthesis of GMP from XMP
SH_RS12510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SH_RS12515	COG0517	IMP dehydrogenase activity
SH_RS12515	COG0516	GMP reductase activity
SH_RS12520	COG2233	PERMEase
SH_RS12525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH_RS12545	COG1823	symporter activity
SH_RS12550	COG0778	Nitroreductase
SH_RS12560	COG0450	alkyl hydroperoxide reductase
SH_RS12565	COG3634	alkyl hydroperoxide reductase activity
SH_RS12575	COG0406	alpha-ribazole phosphatase activity
SH_RS12580	COG1280	lysine exporter protein (LysE YggA)
SH_RS12645	COG3226	Transcriptional regulator
SH_RS12660	COG1131	(ABC) transporter
SH_RS12705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SH_RS12715	COG0360	Binds together with S18 to 16S ribosomal RNA
SH_RS12730	COG0012	GTP binding
SH_RS12735	COG4481	Protein conserved in bacteria
SH_RS12740	COG0668	transmembrane transport
SH_RS12745	COG1475	DNA binding
SH_RS12750	COG0626	cystathionine gamma-synthase activity
SH_RS12755	COG0626	cystathionine gamma-synthase activity
SH_RS12760	COG0646	methionine synthase
SH_RS12760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SH_RS12765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SH_RS12780	COG0488	(ABC) transporter
SH_RS12790	COG0346	lactoylglutathione lyase activity
SH_RS12795	COG3250	beta-galactosidase activity
SH_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
SH_RS12805	COG1312	Catalyzes the dehydration of D-mannonate
SH_RS12810	COG1904	glucuronate isomerase
SH_RS12815	COG2211	Major facilitator Superfamily
SH_RS12820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH_RS12845	COG4175	Glycine betaine
SH_RS12845	COG3448	diguanylate cyclase activity
SH_RS12860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH_RS12885	COG1136	(ABC) transporter
SH_RS12890	COG0577	efflux transmembrane transporter activity
SH_RS12930	COG0357	Ribosomal RNA small subunit methyltransferase G
SH_RS12935	COG0445	tRNA wobble uridine modification
SH_RS12940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SH_RS12945	COG0594	ribonuclease P activity
SH_RS12960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SH_RS13005	COG0187	DNA topoisomerase II activity
SH_RS13025	COG4195	phage-related replication protein