locus-tag	class	description
AV904_RS00010	COG0594	ribonuclease P activity
AV904_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AV904_RS00020	COG0445	tRNA wobble uridine modification
AV904_RS00025	COG0357	Ribosomal RNA small subunit methyltransferase G
AV904_RS00065	COG0577	efflux transmembrane transporter activity
AV904_RS00070	COG1136	(ABC) transporter
AV904_RS00095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AV904_RS00110	COG3448	diguanylate cyclase activity
AV904_RS00110	COG4175	Glycine betaine
AV904_RS00135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV904_RS00140	COG2211	Major facilitator Superfamily
AV904_RS00145	COG1904	glucuronate isomerase
AV904_RS00150	COG1312	Catalyzes the dehydration of D-mannonate
AV904_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS00160	COG3250	beta-galactosidase activity
AV904_RS00175	COG0488	(ABC) transporter
AV904_RS00190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AV904_RS00195	COG0646	methionine synthase
AV904_RS00195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AV904_RS00200	COG0626	cystathionine gamma-synthase activity
AV904_RS00205	COG0626	cystathionine gamma-synthase activity
AV904_RS00210	COG1475	DNA binding
AV904_RS00215	COG0668	transmembrane transport
AV904_RS00220	COG4481	Protein conserved in bacteria
AV904_RS00225	COG0012	GTP binding
AV904_RS00240	COG0360	Binds together with S18 to 16S ribosomal RNA
AV904_RS00250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AV904_RS00290	COG0693	protein deglycase activity
AV904_RS00295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AV904_RS00300	COG1733	regulation of RNA biosynthetic process
AV904_RS00305	COG0579	oxidoreductase
AV904_RS00355	COG1309	transcriptional regulator
AV904_RS00370	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS00375	COG1902	pentaerythritol trinitrate reductase activity
AV904_RS00390	COG1131	(ABC) transporter
AV904_RS00415	COG1280	lysine exporter protein (LysE YggA)
AV904_RS00420	COG0406	alpha-ribazole phosphatase activity
AV904_RS00430	COG3634	alkyl hydroperoxide reductase activity
AV904_RS00435	COG0450	alkyl hydroperoxide reductase
AV904_RS00445	COG0778	Nitroreductase
AV904_RS00450	COG1823	symporter activity
AV904_RS00470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AV904_RS00475	COG2233	PERMEase
AV904_RS00480	COG0516	GMP reductase activity
AV904_RS00480	COG0517	IMP dehydrogenase activity
AV904_RS00485	COG0519	Catalyzes the synthesis of GMP from XMP
AV904_RS00485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AV904_RS00570	COG5484	DNA packaging
AV904_RS00570	COG3728	DNA packaging
AV904_RS00585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AV904_RS00600	COG3759	membrane
AV904_RS00605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AV904_RS00610	COG3002	Belongs to the UPF0753 family
AV904_RS00615	COG5609	conserved protein (DUF2294)
AV904_RS00625	COG0671	phosphoesterase, PA-phosphatase related
AV904_RS00635	COG1647	Serine aminopeptidase, S33
AV904_RS00650	COG0733	neurotransmitter:sodium symporter activity
AV904_RS00670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AV904_RS00675	COG0626	cystathionine gamma-synthase activity
AV904_RS00680	COG3942	CHAP domain
AV904_RS00680	COG1388	LysM domain
AV904_RS00710	COG0583	DNA-binding transcription factor activity
AV904_RS00715	COG0067	glutamate synthase
AV904_RS00715	COG0069	glutamate synthase activity
AV904_RS00715	COG0070	glutamate synthase
AV904_RS00720	COG0493	'glutamate synthase
AV904_RS00730	COG1263	PTS System
AV904_RS00730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS00735	COG0366	Alpha amylase catalytic
AV904_RS00740	COG2188	Transcriptional regulator
AV904_RS00755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AV904_RS00765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AV904_RS00790	COG1982	Orn Lys Arg decarboxylase major
AV904_RS00795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AV904_RS00800	COG3870	Protein conserved in bacteria
AV904_RS00805	COG0470	DNA polymerase III
AV904_RS00810	COG1774	PSP1 C-terminal conserved region
AV904_RS00815	COG4467	Involved in initiation control of chromosome replication
AV904_RS00820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AV904_RS00825	COG2827	Endonuclease containing a URI domain
AV904_RS00830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AV904_RS00835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV904_RS00835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV904_RS00840	COG0084	hydrolase, TatD family'
AV904_RS00845	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AV904_RS00850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AV904_RS00855	COG4466	Protein conserved in bacteria
AV904_RS00860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AV904_RS00865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AV904_RS00870	COG0251	oxidation-reduction process
AV904_RS00875	COG2088	sporulation resulting in formation of a cellular spore
AV904_RS00885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AV904_RS00890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AV904_RS00895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AV904_RS00900	COG0193	aminoacyl-tRNA hydrolase activity
AV904_RS00905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AV904_RS00910	COG2244	polysaccharide biosynthetic process
AV904_RS00915	COG3956	TIGRFAM MazG family protein
AV904_RS00920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AV904_RS00930	COG1098	S1 RNA binding domain
AV904_RS00935	COG0037	tRNA processing
AV904_RS00945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AV904_RS00955	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AV904_RS00960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AV904_RS00975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AV904_RS00980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AV904_RS01065	COG2259	Doxx family
AV904_RS01070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AV904_RS01075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AV904_RS01080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AV904_RS01085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AV904_RS01090	COG4463	regulation of RNA biosynthetic process
AV904_RS01095	COG3880	PFAM UvrB UvrC protein
AV904_RS01100	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AV904_RS01105	COG0542	response to heat
AV904_RS01110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AV904_RS01115	COG4956	integral membrane protein (PIN domain superfamily)
AV904_RS01120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AV904_RS01125	COG1045	serine acetyltransferase
AV904_RS01130	COG0215	cysteine-tRNA ligase activity
AV904_RS01135	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AV904_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV904_RS01145	COG3688	RNA-binding protein containing a PIN domain
AV904_RS01155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV904_RS01160	COG0250	Participates in transcription elongation, termination and antitermination
AV904_RS01165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AV904_RS01170	COG0081	regulation of translation
AV904_RS01180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AV904_RS01185	COG0222	ribosome binding
AV904_RS01190	COG2813	Specifically methylates the guanine in position
AV904_RS01195	COG0085	RNA polymerase activity
AV904_RS01200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AV904_RS01210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AV904_RS01220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AV904_RS01225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AV904_RS01235	COG1473	amidohydrolase
AV904_RS01260	COG0737	Belongs to the 5'-nucleotidase family
AV904_RS01265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AV904_RS01270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AV904_RS01305	COG3177	Filamentation induced by cAMP protein fic
AV904_RS01315	COG0546	phosphoglycolate phosphatase activity
AV904_RS01320	COG1428	Deoxynucleoside kinase
AV904_RS01325	COG1428	Deoxynucleoside kinase
AV904_RS01335	COG0561	phosphatase activity
AV904_RS01340	COG0431	NADPH-dependent FMN reductase
AV904_RS01345	COG4932	domain protein
AV904_RS01375	COG1469	GTP cyclohydrolase I activity
AV904_RS01380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AV904_RS01390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AV904_RS01395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AV904_RS01400	COG0318	PFAM AMP-dependent synthetase and ligase
AV904_RS01405	COG0183	Belongs to the thiolase family
AV904_RS01420	COG0477	Major facilitator Superfamily
AV904_RS01430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AV904_RS01440	COG2363	Small membrane protein
AV904_RS01455	COG2966	Psort location CytoplasmicMembrane, score
AV904_RS01460	COG3253	May function as heme-dependent peroxidase
AV904_RS01470	COG0095	Lipoate-protein ligase
AV904_RS01490	COG4844	belongs to the
AV904_RS01500	COG1278	Cold shock
AV904_RS01505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV904_RS01515	COG0667	Aldo Keto reductase
AV904_RS01520	COG0655	NAD(P)H dehydrogenase (quinone) activity
AV904_RS01530	COG1078	dGTPase activity
AV904_RS01575	COG0018	arginyl-trna synthetase
AV904_RS01580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AV904_RS01595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AV904_RS01600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS01660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AV904_RS01660	COG2111	Na H antiporter
AV904_RS01665	COG2111	Na H antiporter
AV904_RS01670	COG1006	Multisubunit Na H antiporter MnhC subunit
AV904_RS01675	COG0651	ATP synthesis coupled electron transport
AV904_RS01680	COG1863	multisubunit Na H antiporter MnhE subunit
AV904_RS01685	COG2212	antiporter activity
AV904_RS01690	COG1320	monovalent cation:proton antiporter activity
AV904_RS01715	COG1321	iron dependent repressor
AV904_RS01725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AV904_RS01730	COG1134	teichoic acid transport
AV904_RS01735	COG1682	transport, permease protein
AV904_RS01740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AV904_RS01750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AV904_RS01755	COG1686	Belongs to the peptidase S11 family
AV904_RS01760	COG1132	(ABC) transporter
AV904_RS01770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AV904_RS01770	COG0463	Glycosyl transferase, family 2
AV904_RS01775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AV904_RS01785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AV904_RS01790	COG1120	ATPase activity
AV904_RS01795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS01800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS01805	COG2376	Dihydroxyacetone kinase
AV904_RS01815	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AV904_RS01825	COG3949	Membrane
AV904_RS01830	COG0657	acetylesterase activity
AV904_RS01840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AV904_RS01845	COG0745	RESPONSE REGULATOR receiver
AV904_RS01850	COG2205	protein histidine kinase activity
AV904_RS01855	COG1136	(ABC) transporter
AV904_RS01860	COG0577	efflux transmembrane transporter activity
AV904_RS01865	COG1392	Phosphate transport regulator
AV904_RS01870	COG0306	phosphate transporter
AV904_RS01875	COG3942	CHAP domain
AV904_RS01875	COG1388	LysM domain
AV904_RS01895	COG0217	transcriptional regulatory protein
AV904_RS01905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AV904_RS01915	COG0583	DNA-binding transcription factor activity
AV904_RS01925	COG2839	Protein conserved in bacteria
AV904_RS01935	COG0456	acetyltransferase
AV904_RS01950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AV904_RS01955	COG1611	Belongs to the LOG family
AV904_RS01960	COG1671	Belongs to the UPF0178 family
AV904_RS01970	COG1968	undecaprenyl-diphosphatase activity
AV904_RS01975	COG4988	ABC transporter
AV904_RS01980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AV904_RS01990	COG0523	cobalamin synthesis protein
AV904_RS02000	COG0471	metal ion transport
AV904_RS02005	COG0415	Belongs to the DNA photolyase family
AV904_RS02040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AV904_RS02045	COG1349	DNA-binding transcription factor activity
AV904_RS02050	COG1105	Belongs to the carbohydrate kinase PfkB family
AV904_RS02055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AV904_RS02055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AV904_RS02055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AV904_RS02060	COG1253	flavin adenine dinucleotide binding
AV904_RS02065	COG0656	L-ascorbic acid biosynthetic process
AV904_RS02075	COG0463	Glycosyl transferase, family 2
AV904_RS02085	COG0602	queuosine metabolic process
AV904_RS02090	COG0720	synthase
AV904_RS02095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AV904_RS02100	COG0512	Glutamine amidotransferase of anthranilate synthase
AV904_RS02100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AV904_RS02120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AV904_RS02125	COG1984	allophanate hydrolase subunit 2
AV904_RS02130	COG1368	sulfuric ester hydrolase activity
AV904_RS02140	COG0488	(ABC) transporter
AV904_RS02145	COG0514	ATP-dependent DNA helicase (RecQ)
AV904_RS02155	COG1174	glycine betaine transport
AV904_RS02160	COG3104	oligopeptide transport
AV904_RS02165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AV904_RS02175	COG1597	lipid kinase activity
AV904_RS02180	COG3104	oligopeptide transport
AV904_RS02185	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AV904_RS02195	COG1780	Probably involved in ribonucleotide reductase function
AV904_RS02200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV904_RS02205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AV904_RS02210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS02215	COG4605	iron ion homeostasis
AV904_RS02220	COG4604	ABC transporter, ATP-binding protein
AV904_RS02225	COG4607	ABC-type enterochelin transport system periplasmic component
AV904_RS02230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AV904_RS02240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AV904_RS02260	COG1929	Belongs to the glycerate kinase type-1 family
AV904_RS02265	COG2195	Cleaves the N-terminal amino acid of tripeptides
AV904_RS02280	COG2199	diguanylate cyclase activity
AV904_RS02285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AV904_RS02290	COG1739	Uncharacterized protein family UPF0029
AV904_RS02300	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AV904_RS02305	COG1040	competence protein
AV904_RS02310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AV904_RS02315	COG0653	protein targeting
AV904_RS02320	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AV904_RS02325	COG3942	CHAP domain
AV904_RS02325	COG1388	LysM domain
AV904_RS02330	COG0300	oxidoreductase activity
AV904_RS02345	COG0556	nucleotide-excision repair
AV904_RS02350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AV904_RS02355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AV904_RS02360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AV904_RS02375	COG0492	ferredoxin-NADP+ reductase activity
AV904_RS02380	COG1660	Displays ATPase and GTPase activities
AV904_RS02385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AV904_RS02390	COG1481	regulation of sporulation
AV904_RS02400	COG0740	serine-type endopeptidase activity
AV904_RS02405	COG1090	epimerase
AV904_RS02425	COG2390	Transcriptional regulator
AV904_RS02435	COG0126	phosphoglycerate kinase activity
AV904_RS02440	COG0149	triose-phosphate isomerase activity
AV904_RS02445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AV904_RS02450	COG0148	phosphopyruvate hydratase activity
AV904_RS02460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AV904_RS02465	COG1647	Serine aminopeptidase, S33
AV904_RS02470	COG0557	exoribonuclease II activity
AV904_RS02475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AV904_RS02500	COG1396	sequence-specific DNA binding
AV904_RS02510	COG3561	AntA/AntB antirepressor
AV904_RS02620	COG0756	dUTP diphosphatase activity
AV904_RS02725	COG0739	heme binding
AV904_RS02800	COG4195	phage-related replication protein
AV904_RS02805	COG0456	acetyltransferase
AV904_RS02845	COG0406	alpha-ribazole phosphatase activity
AV904_RS02850	COG1279	arginine transmembrane transporter activity
AV904_RS02860	COG1764	response to oxidative stress
AV904_RS02865	COG0710	3-dehydroquinate dehydratase activity
AV904_RS02875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV904_RS02880	COG1393	Belongs to the ArsC family
AV904_RS02885	COG0509	glycine decarboxylation via glycine cleavage system
AV904_RS02890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AV904_RS02900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AV904_RS02905	COG2011	ABC-type metal ion transport system permease component
AV904_RS02910	COG1464	Belongs to the NlpA lipoprotein family
AV904_RS02915	COG3237	CsbD-like
AV904_RS02930	COG0396	ATPase activity
AV904_RS02935	COG0719	Fe-S assembly protein
AV904_RS02945	COG0822	iron-sulfur transferase activity
AV904_RS02950	COG0719	Fe-S assembly protein
AV904_RS02960	COG2070	2-Nitropropane dioxygenase
AV904_RS02965	COG1801	Protein of unknown function DUF72
AV904_RS02970	COG0730	response to heat
AV904_RS02975	COG0737	Belongs to the 5'-nucleotidase family
AV904_RS02980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AV904_RS02985	COG4470	Protein conserved in bacteria
AV904_RS02995	COG2445	Protein of unknown function DUF86
AV904_RS03000	COG0647	UMP catabolic process
AV904_RS03015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AV904_RS03020	COG1696	Membrane protein involved in D-alanine export
AV904_RS03025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV904_RS03030	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AV904_RS03035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AV904_RS03040	COG4837	Protein of unknown function (DUF1462)
AV904_RS03045	COG1252	NADH dehydrogenase
AV904_RS03050	COG4844	belongs to the
AV904_RS03055	COG0316	Belongs to the HesB IscA family
AV904_RS03060	COG1252	NADH dehydrogenase
AV904_RS03065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AV904_RS03070	COG2056	Na+-H+ antiporter family
AV904_RS03075	COG2050	protein possibly involved in aromatic compounds catabolism
AV904_RS03085	COG1320	monovalent cation:proton antiporter activity
AV904_RS03090	COG2212	antiporter activity
AV904_RS03095	COG1863	multisubunit Na H antiporter MnhE subunit
AV904_RS03100	COG0651	ATP synthesis coupled electron transport
AV904_RS03105	COG1006	Multisubunit Na H antiporter MnhC subunit
AV904_RS03110	COG2111	Na H antiporter
AV904_RS03115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AV904_RS03115	COG2111	Na H antiporter
AV904_RS03125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AV904_RS03130	COG1098	S1 RNA binding domain
AV904_RS03135	COG1902	pentaerythritol trinitrate reductase activity
AV904_RS03150	COG0584	glycerophosphoryl diester phosphodiesterase
AV904_RS03155	COG0165	Argininosuccinate lyase
AV904_RS03160	COG0137	argininosuccinate synthase activity
AV904_RS03165	COG0166	Belongs to the GPI family
AV904_RS03170	COG0398	Pfam SNARE associated Golgi protein
AV904_RS03185	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AV904_RS03190	COG1074	ATP-dependent DNA helicase activity
AV904_RS03195	COG0179	Fumarylacetoacetate (FAA) hydrolase
AV904_RS03205	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV904_RS03210	COG0561	phosphatase activity
AV904_RS03225	COG0542	response to heat
AV904_RS03235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AV904_RS03250	COG0601	transmembrane transport
AV904_RS03255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AV904_RS03260	COG0444	Belongs to the ABC transporter superfamily
AV904_RS03265	COG4608	Belongs to the ABC transporter superfamily
AV904_RS03270	COG4166	transmembrane transport
AV904_RS03280	COG0180	Tryptophanyl-tRNA synthetase
AV904_RS03285	COG1393	Belongs to the ArsC family
AV904_RS03290	COG4862	establishment of competence for transformation
AV904_RS03300	COG1164	Oligoendopeptidase f
AV904_RS03310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AV904_RS03315	COG2346	COG2346, Truncated hemoglobins
AV904_RS03320	COG4116	CYTH
AV904_RS03330	COG2357	RelA SpoT domain protein
AV904_RS03335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AV904_RS03340	COG0564	pseudouridine synthase activity
AV904_RS03345	COG2239	Acts as a magnesium transporter
AV904_RS03350	COG0475	glutathione-regulated potassium exporter activity
AV904_RS03350	COG0569	domain protein
AV904_RS03360	COG0628	permease
AV904_RS03365	COG2382	esterase
AV904_RS03370	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AV904_RS03375	COG2814	Major facilitator Superfamily
AV904_RS03380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AV904_RS03385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AV904_RS03395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AV904_RS03400	COG0861	Integral membrane protein TerC family
AV904_RS03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV904_RS03410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AV904_RS03470	COG1575	Belongs to the MenA family. Type 1 subfamily
AV904_RS03475	COG1169	isochorismate synthase
AV904_RS03480	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AV904_RS03485	COG0596	Alpha beta hydrolase
AV904_RS03490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AV904_RS03500	COG0436	Aminotransferase
AV904_RS03505	COG3594	Acyltransferase
AV904_RS03535	COG1316	TRANSCRIPTIONal
AV904_RS03540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AV904_RS03550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AV904_RS03555	COG1845	cytochrome c oxidase, subunit III
AV904_RS03560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AV904_RS03565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AV904_RS03585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AV904_RS03590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AV904_RS03595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AV904_RS03600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AV904_RS03605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AV904_RS03610	COG0047	phosphoribosylformylglycinamidine synthase activity
AV904_RS03615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AV904_RS03625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AV904_RS03635	COG0138	bifunctional purine biosynthesis protein purh
AV904_RS03640	COG0151	Belongs to the GarS family
AV904_RS03645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AV904_RS03650	COG1122	ATPase activity
AV904_RS03665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AV904_RS03680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AV904_RS03700	COG1271	oxidase subunit
AV904_RS03705	COG1294	oxidase, subunit
AV904_RS03710	COG0569	domain protein
AV904_RS03715	COG2832	Protein of unknown function (DUF454)
AV904_RS03725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AV904_RS03730	COG5503	Protein of unknown function (DUF1447)
AV904_RS03735	COG0242	peptide deformylase activity
AV904_RS03765	COG4476	Belongs to the UPF0223 family
AV904_RS03770	COG1396	sequence-specific DNA binding
AV904_RS03770	COG3800	Transcriptional regulator
AV904_RS03775	COG3842	ATPase activity
AV904_RS03780	COG1176	ABC-type spermidine putrescine transport system, permease component I
AV904_RS03785	COG1177	transmembrane transport
AV904_RS03805	COG1914	H( )-stimulated, divalent metal cation uptake system
AV904_RS03810	COG4493	Belongs to the UPF0637 family
AV904_RS03815	COG0483	inositol monophosphate 1-phosphatase activity
AV904_RS03825	COG1217	gtp-binding protein TYPA
AV904_RS03830	COG4896	Protein conserved in bacteria
AV904_RS03835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AV904_RS03840	COG4838	Belongs to the UPF0358 family
AV904_RS03845	COG0772	Belongs to the SEDS family
AV904_RS03855	COG1612	heme a metabolic process
AV904_RS03860	COG0109	protoheme IX farnesyltransferase activity
AV904_RS03870	COG2340	Cysteine-rich secretory protein family
AV904_RS03875	COG3679	Belongs to the UPF0342 family
AV904_RS03885	COG4471	UPF0298 protein
AV904_RS03895	COG0742	ribosomal rna small subunit methyltransferase
AV904_RS03900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AV904_RS03905	COG1323	Belongs to the UPF0348 family
AV904_RS03915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AV904_RS03920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AV904_RS03925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AV904_RS03930	COG0072	phenylalanine-tRNA ligase activity
AV904_RS03930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV904_RS03935	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AV904_RS03940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AV904_RS03950	COG1796	DNA polymerase
AV904_RS03950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AV904_RS03955	COG1193	negative regulation of DNA recombination
AV904_RS03960	COG3118	belongs to the thioredoxin family
AV904_RS03965	COG0322	excinuclease ABC activity
AV904_RS03970	COG2009	succinate dehydrogenase
AV904_RS03975	COG1053	succinate dehydrogenase
AV904_RS03980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AV904_RS03985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AV904_RS03990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AV904_RS04005	COG1011	Hydrolase
AV904_RS04010	COG0454	-acetyltransferase
AV904_RS04015	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AV904_RS04020	COG2001	Belongs to the MraZ family
AV904_RS04025	COG0275	rRNA processing
AV904_RS04030	COG4839	cell division protein FtsL
AV904_RS04035	COG0768	penicillin binding
AV904_RS04040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AV904_RS04045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AV904_RS04050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AV904_RS04055	COG0849	cell division
AV904_RS04060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AV904_RS04065	COG1496	oxidoreductase activity
AV904_RS04070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AV904_RS04075	COG1799	cell septum assembly
AV904_RS04080	COG0762	integral membrane protein
AV904_RS04090	COG3599	regulation of cell shape
AV904_RS04095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AV904_RS04100	COG0702	epimerase
AV904_RS04110	COG1388	LysM domain
AV904_RS04110	COG3942	CHAP domain
AV904_RS04115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AV904_RS04120	COG0564	pseudouridine synthase activity
AV904_RS04125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AV904_RS04130	COG2233	PERMEase
AV904_RS04135	COG0540	Belongs to the ATCase OTCase family
AV904_RS04145	COG0505	Belongs to the CarA family
AV904_RS04150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AV904_RS04155	COG0284	orotidine-5'-phosphate decarboxylase activity
AV904_RS04160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AV904_RS04180	COG0194	GDP metabolic process
AV904_RS04185	COG1758	RNA polymerase activity
AV904_RS04190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AV904_RS04195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AV904_RS04210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AV904_RS04215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AV904_RS04215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AV904_RS04220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AV904_RS04225	COG0631	protein serine/threonine phosphatase activity
AV904_RS04235	COG1162	GTPase activity
AV904_RS04240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AV904_RS04245	COG1564	THIamine pyrophosphokinase
AV904_RS04250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AV904_RS04255	COG1302	Protein conserved in bacteria
AV904_RS04260	COG1461	Dihydroxyacetone kinase
AV904_RS04275	COG1349	DNA-binding transcription factor activity
AV904_RS04280	COG0416	fatty acid biosynthetic process
AV904_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS04295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AV904_RS04300	COG0571	ribonuclease III activity
AV904_RS04305	COG1196	nuclear chromosome segregation
AV904_RS04310	COG0552	protein localization to endoplasmic reticulum
AV904_RS04315	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AV904_RS04320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AV904_RS04325	COG0228	four-way junction DNA binding
AV904_RS04330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AV904_RS04335	COG0336	Belongs to the RNA methyltransferase TrmD family
AV904_RS04340	COG0335	large ribosomal subunit rRNA binding
AV904_RS04350	COG4485	Bacterial membrane protein, YfhO
AV904_RS04360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AV904_RS04365	COG0045	succinate-CoA ligase (ADP-forming) activity
AV904_RS04370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AV904_RS04380	COG0758	DNA mediated transformation
AV904_RS04385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AV904_RS04390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AV904_RS04395	COG4974	Belongs to the 'phage' integrase family
AV904_RS04400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AV904_RS04405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AV904_RS04410	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AV904_RS04415	COG0052	Belongs to the universal ribosomal protein uS2 family
AV904_RS04420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AV904_RS04425	COG0528	UMP kinase activity
AV904_RS04430	COG0233	cytoplasmic translational termination
AV904_RS04435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AV904_RS04440	COG4589	Belongs to the CDS family
AV904_RS04450	COG0442	prolyl-tRNA aminoacylation
AV904_RS04455	COG2176	DNA-directed DNA polymerase activity
AV904_RS04460	COG0779	Required for maturation of 30S ribosomal subunits
AV904_RS04465	COG0195	Participates in both transcription termination and antitermination
AV904_RS04470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AV904_RS04475	COG1358	cellular component organization or biogenesis
AV904_RS04480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AV904_RS04485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AV904_RS04490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AV904_RS04495	COG0196	riboflavin kinase activity
AV904_RS04500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AV904_RS04505	COG1185	polyribonucleotide nucleotidyltransferase activity
AV904_RS04510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AV904_RS04515	COG1674	ftsk spoiiie
AV904_RS04520	COG2188	Transcriptional regulator
AV904_RS04525	COG0612	Peptidase, M16
AV904_RS04530	COG0612	Peptidase, M16
AV904_RS04535	COG0300	oxidoreductase activity
AV904_RS04555	COG1546	Belongs to the CinA family
AV904_RS04555	COG1058	Belongs to the CinA family
AV904_RS04560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AV904_RS04565	COG1418	mRNA catabolic process
AV904_RS04575	COG1692	metallophosphoesterase
AV904_RS04580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AV904_RS04580	COG0674	pyruvate-flavodoxin oxidoreductase activity
AV904_RS04585	COG1013	pyruvate-flavodoxin oxidoreductase activity
AV904_RS04590	COG4195	phage-related replication protein
AV904_RS04600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AV904_RS04605	COG4550	Control of competence regulator ComK, YlbF/YmcA
AV904_RS04615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AV904_RS04620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AV904_RS04630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AV904_RS04635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AV904_RS04640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AV904_RS04650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AV904_RS04655	COG1923	regulation of RNA biosynthetic process
AV904_RS04660	COG0386	Belongs to the glutathione peroxidase family
AV904_RS04665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AV904_RS04670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AV904_RS04675	COG0789	Transcriptional regulator
AV904_RS04725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AV904_RS04730	COG1131	(ABC) transporter
AV904_RS04740	COG4585	Histidine kinase
AV904_RS04745	COG2197	response regulator
AV904_RS04775	COG0527	aspartate kinase activity
AV904_RS04780	COG0460	homoserine dehydrogenase
AV904_RS04785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AV904_RS04790	COG0083	homoserine kinase activity
AV904_RS04805	COG0833	amino acid
AV904_RS04810	COG0753	catalase activity
AV904_RS04820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AV904_RS04825	COG0516	GMP reductase activity
AV904_RS04830	COG2340	Cysteine-rich secretory protein family
AV904_RS04835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AV904_RS04845	COG4224	UPF0291 protein
AV904_RS04860	COG4846	Membrane protein involved in cytochrome C biogenesis
AV904_RS04865	COG0420	3'-5' exonuclease activity
AV904_RS04870	COG0419	ATPase involved in DNA repair
AV904_RS04875	COG1970	mechanosensitive ion channel activity
AV904_RS04880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AV904_RS04885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AV904_RS04890	COG0824	Thioesterase
AV904_RS04895	COG4841	protein insertion into membrane
AV904_RS04900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AV904_RS04905	COG0187	DNA topoisomerase II activity
AV904_RS04910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AV904_RS04915	COG1115	amino acid carrier protein
AV904_RS04920	COG3711	transcriptional antiterminator
AV904_RS04925	COG0628	permease
AV904_RS04930	COG0392	lysyltransferase activity
AV904_RS04930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AV904_RS04945	COG1942	4-Oxalocrotonate Tautomerase
AV904_RS04950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AV904_RS04955	COG0287	Prephenate dehydrogenase
AV904_RS04960	COG1363	Peptidase, m42
AV904_RS04965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AV904_RS04970	COG0512	Glutamine amidotransferase of anthranilate synthase
AV904_RS04975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AV904_RS04980	COG0134	indole-3-glycerol-phosphate synthase activity
AV904_RS04985	COG0135	phosphoribosylanthranilate isomerase activity
AV904_RS04995	COG0159	tryptophan synthase activity
AV904_RS05005	COG2348	transferase activity, transferring amino-acyl groups
AV904_RS05010	COG2348	transferase activity, transferring amino-acyl groups
AV904_RS05020	COG0561	phosphatase activity
AV904_RS05035	COG1164	Oligoendopeptidase f
AV904_RS05040	COG0704	Plays a role in the regulation of phosphate uptake
AV904_RS05045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AV904_RS05050	COG0581	inorganic phosphate transmembrane transporter activity
AV904_RS05055	COG0573	inorganic phosphate transmembrane transporter activity
AV904_RS05060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AV904_RS05065	COG2996	Protein conserved in bacteria
AV904_RS05070	COG0488	(ABC) transporter
AV904_RS05080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AV904_RS05085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV904_RS05090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AV904_RS05095	COG2171	N-acyltransferase activity
AV904_RS05100	COG1473	amidohydrolase
AV904_RS05125	COG1278	Cold shock
AV904_RS05135	COG1254	Belongs to the acylphosphatase family
AV904_RS05145	COG3853	Toxic anion resistance protein (TelA)
AV904_RS05150	COG1114	Component of the transport system for branched-chain amino acids
AV904_RS05155	COG4548	von Willebrand factor, type A
AV904_RS05160	COG0714	Associated with various cellular activities
AV904_RS05180	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV904_RS05185	COG0567	Dehydrogenase, E1 component
AV904_RS05190	COG5002	protein histidine kinase activity
AV904_RS05195	COG0745	RESPONSE REGULATOR receiver
AV904_RS05200	COG0671	phosphoesterase, PA-phosphatase related
AV904_RS05205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AV904_RS05215	COG0793	Belongs to the peptidase S41A family
AV904_RS05220	COG4479	Belongs to the UPF0346 family
AV904_RS05225	COG2190	(PTS) system
AV904_RS05230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV904_RS05250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AV904_RS05260	COG1413	lyase activity
AV904_RS05265	COG1413	lyase activity
AV904_RS05270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AV904_RS05290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV904_RS05295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AV904_RS05305	COG0116	Belongs to the methyltransferase superfamily
AV904_RS05315	COG3599	regulation of cell shape
AV904_RS05320	COG4474	Belongs to the UPF0398 family
AV904_RS05330	COG3331	DNA recombination
AV904_RS05335	COG4499	WXG100 protein secretion system (Wss), protein YukC
AV904_RS05335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AV904_RS05345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AV904_RS05350	COG3935	DnaD domain protein
AV904_RS05355	COG0017	Asparaginyl-tRNA synthetase
AV904_RS05360	COG1199	ATP-dependent helicase activity
AV904_RS05360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AV904_RS05370	COG0617	tRNA 3'-terminal CCA addition
AV904_RS05375	COG0438	transferase activity, transferring glycosyl groups
AV904_RS05380	COG1694	Mazg nucleotide pyrophosphohydrolase
AV904_RS05385	COG2738	Putative neutral zinc metallopeptidase
AV904_RS05390	COG4347	Protein of unknown function (DUF1405)
AV904_RS05395	COG5582	Belongs to the UPF0302 family
AV904_RS05400	COG0457	Tetratricopeptide repeat
AV904_RS05405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AV904_RS05410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AV904_RS05415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AV904_RS05420	COG0105	UTP biosynthetic process
AV904_RS05425	COG0142	geranyltranstransferase activity
AV904_RS05430	COG2226	methyltransferase
AV904_RS05445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AV904_RS05450	COG1160	GTP binding
AV904_RS05455	COG0539	negative regulation of cytoplasmic translation
AV904_RS05460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AV904_RS05470	COG0492	ferredoxin-NADP+ reductase activity
AV904_RS05475	COG1388	LysM domain
AV904_RS05480	COG0514	ATP-dependent DNA helicase (RecQ)
AV904_RS05490	COG1141	Ferredoxin
AV904_RS05505	COG0745	RESPONSE REGULATOR receiver
AV904_RS05510	COG1187	pseudouridine synthase activity
AV904_RS05515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AV904_RS05520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AV904_RS05530	COG4974	Belongs to the 'phage' integrase family
AV904_RS05535	COG0735	belongs to the Fur family
AV904_RS05540	COG0494	nUDIX hydrolase
AV904_RS05545	COG0667	Aldo Keto reductase
AV904_RS05555	COG0300	oxidoreductase activity
AV904_RS05560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AV904_RS05565	COG1234	tRNA 3'-trailer cleavage
AV904_RS05570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AV904_RS05580	COG0366	Alpha amylase catalytic
AV904_RS05585	COG1609	Transcriptional regulator
AV904_RS05600	COG2195	Cleaves the N-terminal amino acid of tripeptides
AV904_RS05610	COG4129	membrane
AV904_RS05620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV904_RS05625	COG0022	dehydrogenase e1 component
AV904_RS05630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AV904_RS05635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV904_RS05640	COG0497	DNA recombination
AV904_RS05645	COG1438	arginine binding
AV904_RS05655	COG1722	exodeoxyribonuclease VII activity
AV904_RS05660	COG1570	exodeoxyribonuclease VII activity
AV904_RS05665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AV904_RS05670	COG1302	Protein conserved in bacteria
AV904_RS05675	COG0439	Biotin carboxylase
AV904_RS05680	COG0511	ligase activity, forming carbon-carbon bonds
AV904_RS05685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AV904_RS05690	COG0006	proline dipeptidase activity
AV904_RS05705	COG0095	Lipoate-protein ligase
AV904_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AV904_RS05715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV904_RS05720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AV904_RS05725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AV904_RS05730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AV904_RS05755	COG4537	Required for transformation and DNA binding
AV904_RS05760	COG1459	type II secretion system
AV904_RS05765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AV904_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV904_RS05865	COG0011	TIGRFAM Protein of
AV904_RS05870	COG1940	carbohydrate kinase activity
AV904_RS05875	COG4483	Protein conserved in bacteria
AV904_RS05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AV904_RS05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AV904_RS05895	COG0768	penicillin binding
AV904_RS05900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AV904_RS05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AV904_RS05915	COG1121	(ABC) transporter
AV904_RS05920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AV904_RS05925	COG0513	Belongs to the DEAD box helicase family
AV904_RS05930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AV904_RS05935	COG2384	SAM-dependent methyltransferase
AV904_RS05940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AV904_RS05950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AV904_RS05955	COG0517	IMP dehydrogenase activity
AV904_RS05960	COG0423	glycine-tRNA ligase activity
AV904_RS05965	COG1381	Involved in DNA repair and RecF pathway recombination
AV904_RS05970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AV904_RS05980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AV904_RS05985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AV904_RS05990	COG1702	phosphate starvation-inducible protein PhoH
AV904_RS06000	COG4864	UPF0365 protein
AV904_RS06005	COG1030	water channel activity
AV904_RS06015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AV904_RS06020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AV904_RS06025	COG2264	protein methyltransferase activity
AV904_RS06030	COG0484	heat shock protein binding
AV904_RS06035	COG0443	Heat shock 70 kDa protein
AV904_RS06040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AV904_RS06045	COG1420	regulation of RNA biosynthetic process
AV904_RS06050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AV904_RS06055	COG0481	GTPase activity
AV904_RS06060	COG0268	Binds directly to 16S ribosomal RNA
AV904_RS06070	COG1466	dna polymerase III delta subunit
AV904_RS06075	COG2333	competence protein COMEC
AV904_RS06075	COG0658	competence protein
AV904_RS06080	COG2131	deaminase
AV904_RS06085	COG1555	photosystem II stabilization
AV904_RS06085	COG1596	polysaccharide export
AV904_RS06090	COG2226	methyltransferase
AV904_RS06095	COG0799	negative regulation of ribosome biogenesis
AV904_RS06100	COG1713	HD superfamily hydrolase involved in NAD metabolism
AV904_RS06105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AV904_RS06110	COG1534	Rna-binding protein
AV904_RS06115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AV904_RS06120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AV904_RS06125	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AV904_RS06130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AV904_RS06135	COG1914	H( )-stimulated, divalent metal cation uptake system
AV904_RS06140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AV904_RS06145	COG0439	Biotin carboxylase
AV904_RS06150	COG0511	ligase activity, forming carbon-carbon bonds
AV904_RS06155	COG1984	allophanate hydrolase subunit 2
AV904_RS06160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AV904_RS06165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AV904_RS06170	COG0572	uridine kinase
AV904_RS06175	COG0826	peptidase U32
AV904_RS06180	COG0826	peptidase U32
AV904_RS06190	COG3906	Belongs to the UPF0473 family
AV904_RS06195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AV904_RS06200	COG4472	Bacterial protein of unknown function (DUF965)
AV904_RS06205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AV904_RS06210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AV904_RS06220	COG0482	sulfurtransferase activity
AV904_RS06225	COG1104	cysteine desulfurase activity
AV904_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV904_RS06235	COG1959	2 iron, 2 sulfur cluster binding
AV904_RS06240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AV904_RS06245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AV904_RS06255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AV904_RS06260	COG0124	histidyl-tRNA synthetase
AV904_RS06265	COG0860	N-Acetylmuramoyl-L-alanine amidase
AV904_RS06270	COG1490	D-aminoacyl-tRNA deacylase activity
AV904_RS06275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AV904_RS06280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AV904_RS06285	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AV904_RS06285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AV904_RS06290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV904_RS06290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AV904_RS06295	COG1862	Preprotein translocase
AV904_RS06300	COG0343	queuine tRNA-ribosyltransferase activity
AV904_RS06305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AV904_RS06310	COG2255	four-way junction helicase activity
AV904_RS06315	COG0632	four-way junction helicase activity
AV904_RS06320	COG4492	Belongs to the UPF0735 family
AV904_RS06325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AV904_RS06330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AV904_RS06335	COG2868	ribosomal protein
AV904_RS06340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AV904_RS06350	COG1792	Involved in formation and maintenance of cell shape
AV904_RS06370	COG2003	Belongs to the UPF0758 family
AV904_RS06375	COG0285	dihydrofolate synthase activity
AV904_RS06380	COG0525	valine-tRNA ligase activity
AV904_RS06385	COG2818	Glycosylase
AV904_RS06395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AV904_RS06410	COG0181	hydroxymethylbilane synthase activity
AV904_RS06415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AV904_RS06420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AV904_RS06425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AV904_RS06430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AV904_RS06435	COG0544	peptidyl-prolyl cis-trans isomerase activity
AV904_RS06445	COG4112	unkown
AV904_RS06450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AV904_RS06455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AV904_RS06460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AV904_RS06465	COG0833	amino acid
AV904_RS06470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AV904_RS06475	COG1484	DNA-dependent DNA replication
AV904_RS06485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AV904_RS06490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AV904_RS06495	COG0237	dephospho-CoA kinase activity
AV904_RS06505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV904_RS06505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AV904_RS06510	COG5002	protein histidine kinase activity
AV904_RS06515	COG0745	RESPONSE REGULATOR receiver
AV904_RS06520	COG0538	isocitrate dehydrogenase activity
AV904_RS06525	COG0372	Belongs to the citrate synthase family
AV904_RS06530	COG1113	amino acid transport
AV904_RS06540	COG0469	pyruvate kinase activity
AV904_RS06545	COG0205	6-phosphofructokinase activity
AV904_RS06550	COG0825	malonyl-CoA metabolic process
AV904_RS06555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AV904_RS06560	COG0281	malic enzyme
AV904_RS06565	COG0587	DNA-directed DNA polymerase activity
AV904_RS06570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AV904_RS06575	COG4109	DRTGG domain
AV904_RS06585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AV904_RS06590	COG0006	proline dipeptidase activity
AV904_RS06595	COG0686	Belongs to the AlaDH PNT family
AV904_RS06600	COG0589	response to stress
AV904_RS06605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AV904_RS06610	COG0827	DNA restriction-modification system
AV904_RS06615	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AV904_RS06620	COG0730	response to heat
AV904_RS06625	COG0301	tRNA thio-modification
AV904_RS06630	COG1104	cysteine desulfurase activity
AV904_RS06640	COG1956	GAF domain-containing protein
AV904_RS06645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AV904_RS06650	COG0584	glycerophosphoryl diester phosphodiesterase
AV904_RS06655	COG1764	response to oxidative stress
AV904_RS06665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AV904_RS06675	COG1263	PTS System
AV904_RS06675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS06680	COG0204	Acyl-transferase
AV904_RS06685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AV904_RS06690	COG0477	Major facilitator Superfamily
AV904_RS06700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AV904_RS06710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AV904_RS06715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AV904_RS06720	COG0454	-acetyltransferase
AV904_RS06730	COG1609	Transcriptional regulator
AV904_RS06735	COG1605	Chorismate mutase
AV904_RS06735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AV904_RS06745	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AV904_RS06750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AV904_RS06755	COG1674	ftsk spoiiie
AV904_RS06760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AV904_RS06765	COG4848	Belongs to the UPF0354 family
AV904_RS06775	COG1363	Peptidase, m42
AV904_RS06785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AV904_RS06790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AV904_RS06795	COG0510	thiamine kinase activity
AV904_RS06805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AV904_RS06815	COG1187	pseudouridine synthase activity
AV904_RS06820	COG2244	polysaccharide biosynthetic process
AV904_RS06825	COG2081	HI0933 family
AV904_RS06830	COG1196	nuclear chromosome segregation
AV904_RS06830	COG1511	domain protein
AV904_RS06830	COG4372	Transposase
AV904_RS06845	COG0495	leucyl-tRNA aminoacylation
AV904_RS06850	COG2814	Major facilitator Superfamily
AV904_RS06855	COG1242	4 iron, 4 sulfur cluster binding
AV904_RS06860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AV904_RS06870	COG2267	carboxylic ester hydrolase activity
AV904_RS06875	COG0506	proline dehydrogenase activity
AV904_RS06880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AV904_RS06885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV904_RS06885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AV904_RS06890	COG0307	riboflavin synthase, alpha
AV904_RS06895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV904_RS06895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AV904_RS06910	COG5632	N-Acetylmuramoyl-L-alanine amidase
AV904_RS06910	COG4193	domain, Protein
AV904_RS06910	COG3266	domain, Protein
AV904_RS06935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AV904_RS06945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AV904_RS06950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AV904_RS06955	COG0656	L-ascorbic acid biosynthetic process
AV904_RS06965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AV904_RS06970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AV904_RS06975	COG1506	peptidase
AV904_RS06980	COG0494	nUDIX hydrolase
AV904_RS06985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AV904_RS06995	COG0318	PFAM AMP-dependent synthetase and ligase
AV904_RS07045	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AV904_RS07050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AV904_RS07055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AV904_RS07060	COG2329	Antibiotic biosynthesis monooxygenase
AV904_RS07065	COG4473	ABC transporter
AV904_RS07070	COG1131	(ABC) transporter
AV904_RS07075	COG0537	adenosine 5'-monophosphoramidase activity
AV904_RS07090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AV904_RS07095	COG3481	metal-dependent phosphohydrolase, HD sub domain
AV904_RS07100	COG4717	serine-type aminopeptidase activity
AV904_RS07110	COG3679	Belongs to the UPF0342 family
AV904_RS07115	COG4399	Belongs to the UPF0754 family
AV904_RS07125	COG2197	response regulator
AV904_RS07130	COG4585	Histidine kinase
AV904_RS07130	COG2203	Gaf domain
AV904_RS07135	COG0564	pseudouridine synthase activity
AV904_RS07140	COG0114	fumarate hydratase activity
AV904_RS07150	COG0363	glucosamine-6-phosphate deaminase activity
AV904_RS07160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AV904_RS07165	COG1126	abc transporter atp-binding protein
AV904_RS07170	COG0765	amino acid transport
AV904_RS07330	COG0735	belongs to the Fur family
AV904_RS07335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV904_RS07340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AV904_RS07345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AV904_RS07350	COG4129	membrane
AV904_RS07360	COG3557	Belongs to the UPF0374 family
AV904_RS07365	COG1194	a g-specific adenine glycosylase
AV904_RS07370	COG1988	membrane-bound metal-dependent
AV904_RS07380	COG1134	teichoic acid transport
AV904_RS07380	COG1388	LysM domain
AV904_RS07390	COG2137	regulation of response to DNA damage stimulus
AV904_RS07395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AV904_RS07400	COG0693	protein deglycase activity
AV904_RS07405	COG0535	radical SAM domain protein
AV904_RS07415	COG1607	acyl-coa hydrolase
AV904_RS07420	COG2309	aminopeptidase activity
AV904_RS07425	COG4840	Belongs to the UPF0435 family
AV904_RS07430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV904_RS07440	COG1295	ribonuclease BN
AV904_RS07445	COG2197	response regulator
AV904_RS07450	COG4585	Histidine kinase
AV904_RS07465	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AV904_RS07470	COG4221	oxidoreductase activity
AV904_RS07475	COG0024	Methionine aminopeptidase
AV904_RS07480	COG4129	membrane
AV904_RS07495	COG1528	Iron-storage protein
AV904_RS07505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AV904_RS07515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AV904_RS07520	COG1597	lipid kinase activity
AV904_RS07525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AV904_RS07530	COG0154	amidase activity
AV904_RS07535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AV904_RS07540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV904_RS07545	COG4851	CamS sex pheromone cAM373 precursor
AV904_RS07550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AV904_RS07555	COG0210	DNA helicase
AV904_RS07560	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AV904_RS07565	COG4496	protein, YerC YecD
AV904_RS07570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AV904_RS07575	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AV904_RS07580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AV904_RS07585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AV904_RS07595	COG1605	Chorismate mutase
AV904_RS07595	COG0077	Prephenate dehydratase
AV904_RS07605	COG1335	isochorismatase
AV904_RS07610	COG1227	inorganic diphosphatase activity
AV904_RS07615	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS07620	COG2706	6-phosphogluconolactonase activity
AV904_RS07655	COG1131	(ABC) transporter
AV904_RS07670	COG1725	Transcriptional regulator
AV904_RS07725	COG0582	viral genome integration into host DNA
AV904_RS07730	COG0459	protein refolding
AV904_RS07735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AV904_RS07760	COG4512	PFAM Accessory gene regulator B
AV904_RS07775	COG3279	Response regulator of the LytR AlgR family
AV904_RS07780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV904_RS07785	COG1621	beta-fructofuranosidase activity
AV904_RS07790	COG1609	Transcriptional regulator
AV904_RS07795	COG0004	ammonium transporteR
AV904_RS07800	COG0425	Belongs to the sulfur carrier protein TusA family
AV904_RS07805	COG2391	methyltransferase activity
AV904_RS07810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AV904_RS07815	COG0488	(ABC) transporter
AV904_RS07820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AV904_RS07825	COG0456	acetyltransferase
AV904_RS07830	COG1214	PFAM Peptidase M22, glycoprotease
AV904_RS07835	COG0802	atpase or kinase
AV904_RS07840	COG0129	dihydroxy-acid dehydratase activity
AV904_RS07845	COG0028	Belongs to the TPP enzyme family
AV904_RS07850	COG0440	acetolactate synthase activity
AV904_RS07855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AV904_RS07860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AV904_RS07865	COG0473	3-isopropylmalate dehydrogenase activity
AV904_RS07870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AV904_RS07875	COG0066	3-isopropylmalate dehydratase activity
AV904_RS07880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AV904_RS07920	COG2183	response to ionizing radiation
AV904_RS07925	COG1191	sigma factor activity
AV904_RS07940	COG2208	phosphoserine phosphatase activity
AV904_RS07945	COG2337	Toxic component of a toxin-antitoxin (TA) module
AV904_RS07955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AV904_RS07960	COG0736	holo-[acyl-carrier-protein] synthase activity
AV904_RS07965	COG3402	PFAM membrane-flanked domain
AV904_RS07970	COG3428	Bacterial PH domain
AV904_RS07980	COG0513	Belongs to the DEAD box helicase family
AV904_RS07985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AV904_RS07990	COG1181	Belongs to the D-alanine--D-alanine ligase family
AV904_RS07995	COG0772	Belongs to the SEDS family
AV904_RS08010	COG1937	Protein conserved in bacteria
AV904_RS08015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AV904_RS08020	COG1418	mRNA catabolic process
AV904_RS08030	COG0706	membrane insertase activity
AV904_RS08035	COG0352	thiamine-phosphate diphosphorylase activity
AV904_RS08040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AV904_RS08050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AV904_RS08055	COG1388	LysM domain
AV904_RS08060	COG0629	single-stranded DNA binding
AV904_RS08070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AV904_RS08075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AV904_RS08085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AV904_RS08090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AV904_RS08095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AV904_RS08100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AV904_RS08105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AV904_RS08110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AV904_RS08115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AV904_RS08120	COG0356	it plays a direct role in the translocation of protons across the membrane
AV904_RS08130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AV904_RS08135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AV904_RS08140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AV904_RS08145	COG4475	Protein of unknown function (DUF436)
AV904_RS08150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV904_RS08155	COG0009	L-threonylcarbamoyladenylate synthase
AV904_RS08160	COG2890	protein-(glutamine-N5) methyltransferase activity
AV904_RS08165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AV904_RS08170	COG1435	thymidine kinase activity
AV904_RS08175	COG0254	rRNA binding
AV904_RS08180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AV904_RS08185	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS08195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AV904_RS08205	COG0191	fructose-bisphosphate aldolase activity
AV904_RS08215	COG0504	CTP synthase activity
AV904_RS08230	COG5146	pantothenate kinase activity
AV904_RS08250	COG1854	S-ribosylhomocysteine lyase activity
AV904_RS08260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AV904_RS08265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AV904_RS08270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AV904_RS08275	COG0813	purine-nucleoside phosphorylase activity
AV904_RS08280	COG0783	Belongs to the Dps family
AV904_RS08300	COG1482	cell wall glycoprotein biosynthetic process
AV904_RS08305	COG0702	epimerase
AV904_RS08310	COG0640	Transcriptional regulator
AV904_RS08330	COG0561	phosphatase activity
AV904_RS08335	COG1119	ATPase activity
AV904_RS08345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AV904_RS08355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AV904_RS08410	COG0489	protein tyrosine kinase activity
AV904_RS08415	COG2814	Major facilitator Superfamily
AV904_RS08430	COG1272	protein, Hemolysin III
AV904_RS08435	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AV904_RS08440	COG1988	membrane-bound metal-dependent
AV904_RS08450	COG2329	Antibiotic biosynthesis monooxygenase
AV904_RS08455	COG3314	Sporulation integral membrane protein YlbJ
AV904_RS08460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS08465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AV904_RS08470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AV904_RS08475	COG3457	Alanine racemase
AV904_RS08485	COG2814	Major facilitator Superfamily
AV904_RS08490	COG4264	IucA IucC family
AV904_RS08495	COG1302	Protein conserved in bacteria
AV904_RS08515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AV904_RS08520	COG0604	alcohol dehydrogenase
AV904_RS08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV904_RS08535	COG2723	6-phospho-beta-galactosidase activity
AV904_RS08540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AV904_RS08540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AV904_RS08545	COG1447	Phosphotransferase system cellobiose-specific component IIA
AV904_RS08550	COG3684	Belongs to the aldolase LacD family
AV904_RS08555	COG1105	Belongs to the carbohydrate kinase PfkB family
AV904_RS08560	COG0698	ribose 5-phosphate isomerase
AV904_RS08565	COG0698	ribose 5-phosphate isomerase
AV904_RS08570	COG1349	DNA-binding transcription factor activity
AV904_RS08575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AV904_RS08580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AV904_RS08585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AV904_RS08590	COG0101	tRNA pseudouridine synthase activity
AV904_RS08600	COG1122	ATPase activity
AV904_RS08605	COG1122	ATPase activity
AV904_RS08610	COG0203	ribosomal protein L17
AV904_RS08615	COG0202	RNA polymerase activity
AV904_RS08625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AV904_RS08630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AV904_RS08635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AV904_RS08640	COG0563	adenylate kinase activity
AV904_RS08645	COG0201	protein transport
AV904_RS08650	COG0200	Binds to the 23S rRNA
AV904_RS08655	COG1841	ribosomal large subunit assembly
AV904_RS08660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AV904_RS08665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AV904_RS08670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AV904_RS08675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AV904_RS08685	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AV904_RS08690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AV904_RS08695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AV904_RS08700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AV904_RS08705	COG0255	Belongs to the universal ribosomal protein uL29 family
AV904_RS08710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AV904_RS08715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AV904_RS08720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AV904_RS08725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AV904_RS08730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AV904_RS08735	COG0089	rRNA binding
AV904_RS08740	COG0088	Forms part of the polypeptide exit tunnel
AV904_RS08745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AV904_RS08750	COG0051	transcription antitermination factor activity, RNA binding
AV904_RS08760	COG2252	PERMEase
AV904_RS08765	COG0551	DNA topoisomerase type I activity
AV904_RS08765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AV904_RS08775	COG4975	Glucose uptake
AV904_RS08795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AV904_RS08800	COG2348	transferase activity, transferring amino-acyl groups
AV904_RS08825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AV904_RS08830	COG0746	molybdenum cofactor guanylyltransferase activity
AV904_RS08855	COG0315	cyclic pyranopterin monophosphate synthase activity
AV904_RS08865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AV904_RS08870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AV904_RS08875	COG4149	molybdate abc transporter
AV904_RS08880	COG0725	ABC transporter, periplasmic molybdate-binding protein
AV904_RS08885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AV904_RS08895	COG1268	BioY protein
AV904_RS08900	COG1957	nucleoside hydrolase
AV904_RS08905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AV904_RS08910	COG1960	acyl-CoA dehydrogenase activity
AV904_RS08935	COG3942	CHAP domain
AV904_RS08945	COG1757	Na H antiporter
AV904_RS08960	COG3942	CHAP domain
AV904_RS08965	COG2076	Multidrug Resistance protein
AV904_RS08970	COG2076	Multidrug Resistance protein
AV904_RS08975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AV904_RS08995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AV904_RS09000	COG3383	formate dehydrogenase (NAD+) activity
AV904_RS09005	COG1316	TRANSCRIPTIONal
AV904_RS09015	COG2378	regulation of single-species biofilm formation
AV904_RS09030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AV904_RS09035	COG1263	PTS System
AV904_RS09035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS09045	COG1113	amino acid transport
AV904_RS09065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AV904_RS09075	COG1263	PTS System
AV904_RS09075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS09080	COG1737	Transcriptional regulator
AV904_RS09095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AV904_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS09105	COG1473	amidohydrolase
AV904_RS09110	COG0659	secondary active sulfate transmembrane transporter activity
AV904_RS09115	COG0010	Belongs to the arginase family
AV904_RS09120	COG1266	CAAX protease self-immunity
AV904_RS09125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AV904_RS09140	COG1742	UPF0060 membrane protein
AV904_RS09155	COG2094	Belongs to the DNA glycosylase MPG family
AV904_RS09160	COG0786	glutamate:sodium symporter activity
AV904_RS09165	COG1304	FMN binding
AV904_RS09170	COG0598	Magnesium transport protein CorA
AV904_RS09195	COG2814	Major facilitator Superfamily
AV904_RS09200	COG1566	PFAM secretion protein HlyD family protein
AV904_RS09210	COG2814	Major facilitator Superfamily
AV904_RS09215	COG4640	response to antibiotic
AV904_RS09230	COG1136	(ABC) transporter
AV904_RS09235	COG0577	efflux transmembrane transporter activity
AV904_RS09240	COG0745	RESPONSE REGULATOR receiver
AV904_RS09245	COG3850	Histidine kinase
AV904_RS09245	COG5002	protein histidine kinase activity
AV904_RS09260	COG0579	oxidoreductase
AV904_RS09265	COG0438	transferase activity, transferring glycosyl groups
AV904_RS09270	COG1620	l-lactate permease
AV904_RS09275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AV904_RS09275	COG0463	Glycosyl transferase, family 2
AV904_RS09285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AV904_RS09290	COG0805	protein transport
AV904_RS09295	COG0672	)-iron permease
AV904_RS09300	COG2837	iron assimilation
AV904_RS09305	COG2822	iron ion transport
AV904_RS09310	COG0604	alcohol dehydrogenase
AV904_RS09320	COG0492	ferredoxin-NADP+ reductase activity
AV904_RS09350	COG1511	domain protein
AV904_RS09365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS09365	COG1263	PTS System
AV904_RS09380	COG3871	stress protein (general stress protein 26)
AV904_RS09400	COG1846	Transcriptional regulator
AV904_RS09410	COG2223	nitrite transmembrane transporter activity
AV904_RS09415	COG2197	response regulator
AV904_RS09420	COG4585	Histidine kinase
AV904_RS09430	COG2181	nitrate reductase activity
AV904_RS09435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AV904_RS09440	COG1140	nitrate reductase beta subunit
AV904_RS09445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AV904_RS09455	COG2146	nitrite reductase [NAD(P)H] activity
AV904_RS09460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AV904_RS09485	COG2353	YceI-like domain
AV904_RS09490	COG3443	Belongs to the bacterial solute-binding protein 9 family
AV904_RS09490	COG0803	Belongs to the bacterial solute-binding protein 9 family
AV904_RS09510	COG1126	abc transporter atp-binding protein
AV904_RS09515	COG0765	amino acid transport
AV904_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AV904_RS09525	COG2814	Major facilitator Superfamily
AV904_RS09530	COG0588	phosphoglycerate mutase activity
AV904_RS09535	COG0741	lytic transglycosylase activity
AV904_RS09540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AV904_RS09555	COG1929	Belongs to the glycerate kinase type-1 family
AV904_RS09565	COG2814	Major facilitator Superfamily
AV904_RS09570	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AV904_RS09575	COG2226	methyltransferase
AV904_RS09595	COG1113	amino acid transport
AV904_RS09605	COG0531	amino acid
AV904_RS09615	COG0706	membrane insertase activity
AV904_RS09625	COG3477	response to acidic pH
AV904_RS09630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AV904_RS09640	COG3275	phosphorelay sensor kinase activity
AV904_RS09645	COG3279	Response regulator of the LytR AlgR family
AV904_RS09650	COG1380	Effector of murein hydrolase LrgA
AV904_RS09655	COG1346	cytolysis
AV904_RS09660	COG1174	glycine betaine transport
AV904_RS09680	COG1063	alcohol dehydrogenase
AV904_RS09685	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AV904_RS09690	COG0531	amino acid
AV904_RS09695	COG2272	Belongs to the type-B carboxylesterase lipase family
AV904_RS09700	COG2814	Major facilitator Superfamily
AV904_RS09710	COG0745	RESPONSE REGULATOR receiver
AV904_RS09715	COG2205	protein histidine kinase activity
AV904_RS09720	COG0390	transport system, permease component
AV904_RS09725	COG4619	ABC transporter
AV904_RS09740	COG0069	glutamate synthase activity
AV904_RS09755	COG1363	Peptidase, m42
AV904_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS09765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AV904_RS09775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AV904_RS09780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AV904_RS09785	COG4221	oxidoreductase activity
AV904_RS09810	COG0494	nUDIX hydrolase
AV904_RS09815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AV904_RS09840	COG2610	gluconate transmembrane transporter activity
AV904_RS09845	COG1070	Carbohydrate kinase
AV904_RS09850	COG1802	Transcriptional regulator
AV904_RS09865	COG2357	RelA SpoT domain protein
AV904_RS09870	COG4876	unkown
AV904_RS09885	COG2271	Major facilitator Superfamily
AV904_RS09895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AV904_RS09900	COG2022	thiamine diphosphate biosynthetic process
AV904_RS09900	COG2104	thiamine diphosphate biosynthetic process
AV904_RS09905	COG2022	thiamine diphosphate biosynthetic process
AV904_RS09915	COG0586	Pfam SNARE associated Golgi protein
AV904_RS09920	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AV904_RS09930	COG3949	Membrane
AV904_RS09935	COG0400	carboxylic ester hydrolase activity
AV904_RS09940	COG0346	lactoylglutathione lyase activity
AV904_RS09945	COG0346	lactoylglutathione lyase activity
AV904_RS09950	COG1846	Transcriptional regulator
AV904_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS09970	COG2514	catechol 2,3-dioxygenase activity
AV904_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS09985	COG0778	Nitroreductase
AV904_RS10000	COG3764	Sortase (surface protein transpeptidase)
AV904_RS10015	COG1760	l-serine dehydratase
AV904_RS10020	COG1760	l-serine dehydratase
AV904_RS10030	COG1070	Carbohydrate kinase
AV904_RS10050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AV904_RS10070	COG0697	spore germination
AV904_RS10080	COG0039	L-malate dehydrogenase activity
AV904_RS10085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AV904_RS10095	COG1063	alcohol dehydrogenase
AV904_RS10100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS10100	COG1263	PTS System
AV904_RS10100	COG2190	(PTS) system
AV904_RS10110	COG0028	Belongs to the TPP enzyme family
AV904_RS10115	COG1346	cytolysis
AV904_RS10120	COG1380	Effector of murein hydrolase LrgA
AV904_RS10130	COG0583	DNA-binding transcription factor activity
AV904_RS10140	COG1388	LysM domain
AV904_RS10140	COG3942	CHAP domain
AV904_RS10155	COG3425	synthase
AV904_RS10160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AV904_RS10190	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS10195	COG0110	maltose O-acetyltransferase activity
AV904_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS10210	COG2217	Heavy metal translocating P-type atpase
AV904_RS10215	COG2608	mercury ion transmembrane transporter activity
AV904_RS10225	COG0436	Aminotransferase
AV904_RS10230	COG1233	COG1233 Phytoene dehydrogenase and related
AV904_RS10235	COG1562	ergosterol biosynthetic process
AV904_RS10245	COG1233	COG1233 Phytoene dehydrogenase and related
AV904_RS10255	COG0741	lytic transglycosylase activity
AV904_RS10280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV904_RS10315	COG0596	Alpha beta hydrolase
AV904_RS10330	COG3001	Fructosamine kinase
AV904_RS10335	COG0167	dihydroorotate dehydrogenase activity
AV904_RS10345	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AV904_RS10375	COG3527	Alpha-acetolactate decarboxylase
AV904_RS10380	COG0028	Belongs to the TPP enzyme family
AV904_RS10385	COG0531	amino acid
AV904_RS10400	COG1464	Belongs to the NlpA lipoprotein family
AV904_RS10425	COG0563	adenylate kinase activity
AV904_RS10430	COG3588	fructose-bisphosphate aldolase
AV904_RS10445	COG2723	6-phospho-beta-galactosidase activity
AV904_RS10450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AV904_RS10455	COG0579	oxidoreductase
AV904_RS10460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AV904_RS10465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AV904_RS10465	COG0574	Belongs to the PEP-utilizing enzyme family
AV904_RS10470	COG0583	DNA-binding transcription factor activity
AV904_RS10480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AV904_RS10495	COG1473	amidohydrolase
AV904_RS10505	COG1473	amidohydrolase
AV904_RS10515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AV904_RS10520	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS10525	COG1510	regulation of RNA biosynthetic process
AV904_RS10530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AV904_RS10535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AV904_RS10550	COG2851	Citrate transporter
AV904_RS10555	COG0529	Catalyzes the synthesis of activated sulfate
AV904_RS10560	COG2046	Belongs to the sulfate adenylyltransferase family
AV904_RS10565	COG0730	response to heat
AV904_RS10580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AV904_RS10585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AV904_RS10590	COG0175	sulfate reduction
AV904_RS10620	COG1136	(ABC) transporter
AV904_RS10625	COG2205	protein histidine kinase activity
AV904_RS10635	COG1785	Belongs to the alkaline phosphatase family
AV904_RS10640	COG1316	TRANSCRIPTIONal
AV904_RS10645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AV904_RS10650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AV904_RS10660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AV904_RS10665	COG0297	glycogen (starch) synthase activity
AV904_RS10690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AV904_RS10725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AV904_RS10735	COG3961	Belongs to the TPP enzyme family
AV904_RS10740	COG2843	Capsule synthesis protein
AV904_RS10745	COG5658	integral membrane protein
AV904_RS10770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AV904_RS10780	COG2235	arginine
AV904_RS10815	COG1705	Flagellar rod assembly protein muramidase FlgJ
AV904_RS10815	COG3942	CHAP domain
AV904_RS10815	COG1705	Flagellar rod assembly protein muramidase FlgJ
AV904_RS10815	COG3942	CHAP domain
AV904_RS10820	COG1263	PTS System
AV904_RS10820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AV904_RS10820	COG2190	(PTS) system
AV904_RS10825	COG1288	antiporter activity
AV904_RS10835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AV904_RS10840	COG0583	DNA-binding transcription factor activity
AV904_RS10845	COG2409	Drug exporters of the RND superfamily
AV904_RS10850	COG2113	Glycine betaine
AV904_RS10860	COG2814	Major facilitator Superfamily
AV904_RS10880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AV904_RS10900	COG0745	RESPONSE REGULATOR receiver
AV904_RS10905	COG0642	Histidine kinase
AV904_RS10920	COG0653	protein targeting
AV904_RS10930	COG1073	alpha beta
AV904_RS10940	COG0201	protein transport
AV904_RS10955	COG3391	amine dehydrogenase activity
AV904_RS10980	COG3639	organic phosphonate transmembrane transporter activity
AV904_RS10985	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AV904_RS10995	COG0737	Belongs to the 5'-nucleotidase family
AV904_RS11005	COG2814	Major facilitator Superfamily
AV904_RS11010	COG0697	spore germination
AV904_RS11015	COG1959	2 iron, 2 sulfur cluster binding
AV904_RS11020	COG1476	TRANSCRIPTIONal
AV904_RS11030	COG1131	(ABC) transporter
AV904_RS11050	COG4716	Myosin-crossreactive antigen
AV904_RS11070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AV904_RS11075	COG3386	PFAM SMP-30 Gluconolaconase
AV904_RS11080	COG1054	Belongs to the UPF0176 family
AV904_RS11090	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AV904_RS11110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AV904_RS11115	COG0747	negative chemotaxis
AV904_RS11130	COG0444	Belongs to the ABC transporter superfamily
AV904_RS11135	COG1124	(ABC) transporter
AV904_RS11160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AV904_RS11165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AV904_RS11180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AV904_RS11185	COG0363	glucosamine-6-phosphate deaminase activity
AV904_RS11195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AV904_RS11205	COG4336	lyase activity
AV904_RS11210	COG5505	Protein of unknown function (DUF819)
AV904_RS11215	COG0471	metal ion transport
AV904_RS11225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AV904_RS11235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AV904_RS11265	COG3093	addiction module antidote protein HigA
AV904_RS11275	COG0549	Belongs to the carbamate kinase family
AV904_RS11280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AV904_RS11290	COG2314	TM2 domain
AV904_RS11310	COG0789	Transcriptional regulator
AV904_RS11345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AV904_RS11370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AV904_RS11380	COG2962	Rard protein
AV904_RS11385	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
AV904_RS11390	COG2213	PTS system mannitol-specific
AV904_RS11395	COG3711	transcriptional antiterminator
AV904_RS11405	COG0246	Mannitol dehydrogenase
AV904_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS11420	COG1695	Transcriptional regulator
AV904_RS11425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV904_RS11430	COG0508	dehydrogenase complex catalyzes the overall conversion of
AV904_RS11435	COG0022	dehydrogenase e1 component
AV904_RS11440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AV904_RS11445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV904_RS11455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AV904_RS11470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AV904_RS11475	COG1846	Transcriptional regulator
AV904_RS11480	COG1063	alcohol dehydrogenase
AV904_RS11485	COG1012	belongs to the aldehyde dehydrogenase family
AV904_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
AV904_RS11530	COG2318	DinB family
AV904_RS11540	COG1288	antiporter activity
AV904_RS11545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AV904_RS11555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AV904_RS11565	COG3152	Membrane
AV904_RS11575	COG2971	BadF BadG BcrA BcrD
AV904_RS11590	COG1447	Phosphotransferase system cellobiose-specific component IIA
AV904_RS11595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AV904_RS11600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AV904_RS11605	COG1737	Transcriptional regulator
AV904_RS11610	COG1876	peptidase activity
AV904_RS11620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AV904_RS11625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AV904_RS11630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AV904_RS11635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AV904_RS11640	COG1879	ABC-type sugar transport system periplasmic component
AV904_RS11650	COG1129	ABC transporter
AV904_RS11655	COG1869	D-ribose catabolic process
AV904_RS11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AV904_RS11665	COG1609	Transcriptional regulator
AV904_RS11710	COG0778	Nitroreductase
AV904_RS11715	COG1113	amino acid transport
AV904_RS11735	COG2910	NAD(P)H-binding
AV904_RS11740	COG1959	2 iron, 2 sulfur cluster binding
AV904_RS11745	COG1253	flavin adenine dinucleotide binding
AV904_RS11775	COG4172	Belongs to the ABC transporter superfamily
AV904_RS11780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AV904_RS11790	COG0747	negative chemotaxis
AV904_RS11800	COG1114	Component of the transport system for branched-chain amino acids
AV904_RS11815	COG1121	(ABC) transporter
AV904_RS11820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AV904_RS11825	COG0803	Belongs to the bacterial solute-binding protein 9 family
AV904_RS11835	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
AV904_RS11885	COG0803	Belongs to the bacterial solute-binding protein 9 family
AV904_RS11890	COG0523	cobalamin synthesis protein
AV904_RS11900	COG0668	transmembrane transport
AV904_RS11915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AV904_RS11920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV904_RS11945	COG0701	Predicted permease
AV904_RS11950	COG0640	Transcriptional regulator
AV904_RS11970	COG0446	pyridine nucleotide-disulphide oxidoreductase
AV904_RS11980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AV904_RS11985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV904_RS11990	COG1388	LysM domain
AV904_RS11995	COG2132	Multicopper oxidase
AV904_RS12000	COG2217	Heavy metal translocating P-type atpase
AV904_RS12015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AV904_RS12020	COG0640	Transcriptional regulator
AV904_RS12035	COG2130	NADP-dependent
AV904_RS12040	COG0702	epimerase
AV904_RS12050	COG0789	Transcriptional regulator
AV904_RS12120	COG2030	dehydratase
AV904_RS12125	COG0584	glycerophosphoryl diester phosphodiesterase
AV904_RS12155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AV904_RS12160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AV904_RS12170	COG4863	YycH protein
AV904_RS12175	COG5002	protein histidine kinase activity
AV904_RS12180	COG0745	RESPONSE REGULATOR receiver
AV904_RS12195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AV904_RS12200	COG0305	Participates in initiation and elongation during chromosome replication
AV904_RS12205	COG0359	binds to the 23S rRNA
AV904_RS12210	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AV904_RS12220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AV904_RS12230	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AV904_RS12235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AV904_RS12240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AV904_RS12245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AV904_RS12250	COG0187	DNA topoisomerase II activity
AV904_RS12255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AV904_RS12260	COG2501	S4 domain
AV904_RS12265	COG0592	DNA-directed DNA polymerase activity
AV904_RS12270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AV904_RS12295	COG1475	DNA binding