locus-tag	class	description
CWR44_RS00040	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR44_RS00045	COG0772	Belongs to the SEDS family
CWR44_RS00065	COG1937	Protein conserved in bacteria
CWR44_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR44_RS00075	COG1418	mRNA catabolic process
CWR44_RS00085	COG0706	membrane insertase activity
CWR44_RS00090	COG0352	thiamine-phosphate diphosphorylase activity
CWR44_RS00095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWR44_RS00105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CWR44_RS00110	COG1388	LysM domain
CWR44_RS00115	COG0629	single-stranded DNA binding
CWR44_RS00125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWR44_RS00130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWR44_RS00140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWR44_RS00145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWR44_RS00150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWR44_RS00155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWR44_RS00160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR44_RS00165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWR44_RS00170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR44_RS00175	COG0356	it plays a direct role in the translocation of protons across the membrane
CWR44_RS00185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWR44_RS00190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWR44_RS00195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWR44_RS00200	COG4475	Protein of unknown function (DUF436)
CWR44_RS00205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWR44_RS00210	COG0009	L-threonylcarbamoyladenylate synthase
CWR44_RS00215	COG2890	protein-(glutamine-N5) methyltransferase activity
CWR44_RS00220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWR44_RS00225	COG1435	thymidine kinase activity
CWR44_RS00230	COG0254	rRNA binding
CWR44_RS00235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWR44_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS00250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWR44_RS00255	COG0191	fructose-bisphosphate aldolase activity
CWR44_RS00265	COG0504	CTP synthase activity
CWR44_RS00280	COG5146	pantothenate kinase activity
CWR44_RS00300	COG1854	S-ribosylhomocysteine lyase activity
CWR44_RS00310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWR44_RS00315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CWR44_RS00320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWR44_RS00325	COG0813	purine-nucleoside phosphorylase activity
CWR44_RS00330	COG0783	Belongs to the Dps family
CWR44_RS00350	COG1482	cell wall glycoprotein biosynthetic process
CWR44_RS00355	COG0702	epimerase
CWR44_RS00360	COG0640	Transcriptional regulator
CWR44_RS00385	COG0561	phosphatase activity
CWR44_RS00390	COG1119	ATPase activity
CWR44_RS00400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR44_RS00410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CWR44_RS00465	COG0489	protein tyrosine kinase activity
CWR44_RS00470	COG2814	Major facilitator Superfamily
CWR44_RS00485	COG1272	protein, Hemolysin III
CWR44_RS00490	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CWR44_RS00495	COG1988	membrane-bound metal-dependent
CWR44_RS00505	COG2329	Antibiotic biosynthesis monooxygenase
CWR44_RS00510	COG3314	Sporulation integral membrane protein YlbJ
CWR44_RS00515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS00520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS00525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CWR44_RS00530	COG3457	Alanine racemase
CWR44_RS00540	COG2814	Major facilitator Superfamily
CWR44_RS00545	COG4264	IucA IucC family
CWR44_RS00550	COG1302	Protein conserved in bacteria
CWR44_RS00565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWR44_RS00570	COG0604	alcohol dehydrogenase
CWR44_RS00575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWR44_RS00585	COG2723	6-phospho-beta-galactosidase activity
CWR44_RS00590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR44_RS00590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR44_RS00595	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR44_RS00600	COG3684	Belongs to the aldolase LacD family
CWR44_RS00605	COG1105	Belongs to the carbohydrate kinase PfkB family
CWR44_RS00610	COG0698	ribose 5-phosphate isomerase
CWR44_RS00615	COG0698	ribose 5-phosphate isomerase
CWR44_RS00620	COG1349	DNA-binding transcription factor activity
CWR44_RS00625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CWR44_RS00630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWR44_RS00635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWR44_RS00640	COG0101	tRNA pseudouridine synthase activity
CWR44_RS00650	COG1122	ATPase activity
CWR44_RS00655	COG1122	ATPase activity
CWR44_RS00660	COG0203	ribosomal protein L17
CWR44_RS00665	COG0202	RNA polymerase activity
CWR44_RS00675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWR44_RS00680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWR44_RS00685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWR44_RS00690	COG0563	adenylate kinase activity
CWR44_RS00695	COG0201	protein transport
CWR44_RS00700	COG0200	Binds to the 23S rRNA
CWR44_RS00705	COG1841	ribosomal large subunit assembly
CWR44_RS00710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWR44_RS00715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWR44_RS00720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWR44_RS00725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWR44_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWR44_RS00740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWR44_RS00745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWR44_RS00750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWR44_RS00755	COG0255	Belongs to the universal ribosomal protein uL29 family
CWR44_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWR44_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWR44_RS00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWR44_RS00775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWR44_RS00780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWR44_RS00785	COG0089	rRNA binding
CWR44_RS00790	COG0088	Forms part of the polypeptide exit tunnel
CWR44_RS00795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWR44_RS00800	COG0051	transcription antitermination factor activity, RNA binding
CWR44_RS00810	COG2252	PERMEase
CWR44_RS00815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWR44_RS00815	COG0551	DNA topoisomerase type I activity
CWR44_RS00825	COG4975	Glucose uptake
CWR44_RS00845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWR44_RS00850	COG2348	transferase activity, transferring amino-acyl groups
CWR44_RS00880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWR44_RS00885	COG0746	molybdenum cofactor guanylyltransferase activity
CWR44_RS00910	COG0315	cyclic pyranopterin monophosphate synthase activity
CWR44_RS00920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWR44_RS00925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CWR44_RS00930	COG4149	molybdate abc transporter
CWR44_RS00935	COG0725	ABC transporter, periplasmic molybdate-binding protein
CWR44_RS00940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CWR44_RS00950	COG1268	BioY protein
CWR44_RS00955	COG1957	nucleoside hydrolase
CWR44_RS00960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWR44_RS00965	COG1960	acyl-CoA dehydrogenase activity
CWR44_RS00990	COG3942	CHAP domain
CWR44_RS01000	COG1757	Na H antiporter
CWR44_RS01015	COG3942	CHAP domain
CWR44_RS01020	COG2076	Multidrug Resistance protein
CWR44_RS01025	COG2076	Multidrug Resistance protein
CWR44_RS01030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWR44_RS01050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWR44_RS01055	COG3383	formate dehydrogenase (NAD+) activity
CWR44_RS01060	COG1316	TRANSCRIPTIONal
CWR44_RS01070	COG2378	regulation of single-species biofilm formation
CWR44_RS01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CWR44_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS01090	COG1263	PTS System
CWR44_RS01100	COG1113	amino acid transport
CWR44_RS01120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR44_RS01130	COG1263	PTS System
CWR44_RS01130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS01135	COG1737	Transcriptional regulator
CWR44_RS01150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CWR44_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
CWR44_RS01160	COG1473	amidohydrolase
CWR44_RS01170	COG0010	Belongs to the arginase family
CWR44_RS01175	COG1266	CAAX protease self-immunity
CWR44_RS01180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CWR44_RS01185	COG2258	MOSC domain
CWR44_RS01195	COG1742	UPF0060 membrane protein
CWR44_RS01210	COG2094	Belongs to the DNA glycosylase MPG family
CWR44_RS01215	COG0786	glutamate:sodium symporter activity
CWR44_RS01220	COG1304	FMN binding
CWR44_RS01225	COG0598	Magnesium transport protein CorA
CWR44_RS01250	COG2814	Major facilitator Superfamily
CWR44_RS01255	COG1566	PFAM secretion protein HlyD family protein
CWR44_RS01275	COG2814	Major facilitator Superfamily
CWR44_RS01280	COG4640	response to antibiotic
CWR44_RS01295	COG1136	(ABC) transporter
CWR44_RS01300	COG0577	efflux transmembrane transporter activity
CWR44_RS01305	COG0745	RESPONSE REGULATOR receiver
CWR44_RS01310	COG3850	Histidine kinase
CWR44_RS01310	COG5002	protein histidine kinase activity
CWR44_RS01325	COG0579	oxidoreductase
CWR44_RS01330	COG0438	transferase activity, transferring glycosyl groups
CWR44_RS01335	COG1620	l-lactate permease
CWR44_RS01340	COG0463	Glycosyl transferase, family 2
CWR44_RS01340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWR44_RS01350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWR44_RS01355	COG0805	protein transport
CWR44_RS01360	COG0672	)-iron permease
CWR44_RS01365	COG2837	iron assimilation
CWR44_RS01370	COG2822	iron ion transport
CWR44_RS01375	COG0604	alcohol dehydrogenase
CWR44_RS01385	COG0492	ferredoxin-NADP+ reductase activity
CWR44_RS01415	COG1511	domain protein
CWR44_RS01430	COG1263	PTS System
CWR44_RS01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS01445	COG3871	stress protein (general stress protein 26)
CWR44_RS01465	COG1846	Transcriptional regulator
CWR44_RS01475	COG2223	nitrite transmembrane transporter activity
CWR44_RS01480	COG2197	response regulator
CWR44_RS01485	COG4585	Histidine kinase
CWR44_RS01495	COG2181	nitrate reductase activity
CWR44_RS01500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CWR44_RS01505	COG1140	nitrate reductase beta subunit
CWR44_RS01510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CWR44_RS01520	COG2146	nitrite reductase [NAD(P)H] activity
CWR44_RS01525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWR44_RS01550	COG2353	YceI-like domain
CWR44_RS01555	COG3443	Belongs to the bacterial solute-binding protein 9 family
CWR44_RS01555	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWR44_RS01575	COG1126	abc transporter atp-binding protein
CWR44_RS01580	COG0765	amino acid transport
CWR44_RS01585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR44_RS01590	COG2814	Major facilitator Superfamily
CWR44_RS01600	COG0588	phosphoglycerate mutase activity
CWR44_RS01605	COG0741	lytic transglycosylase activity
CWR44_RS01610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWR44_RS01625	COG1929	Belongs to the glycerate kinase type-1 family
CWR44_RS01635	COG2814	Major facilitator Superfamily
CWR44_RS01640	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CWR44_RS01645	COG2226	methyltransferase
CWR44_RS01665	COG1113	amino acid transport
CWR44_RS01670	COG0025	NhaP-type Na H and K H
CWR44_RS01675	COG0531	amino acid
CWR44_RS01685	COG0706	membrane insertase activity
CWR44_RS01695	COG3477	response to acidic pH
CWR44_RS01700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWR44_RS01710	COG3275	phosphorelay sensor kinase activity
CWR44_RS01715	COG3279	Response regulator of the LytR AlgR family
CWR44_RS01725	COG1380	Effector of murein hydrolase LrgA
CWR44_RS01730	COG1346	cytolysis
CWR44_RS01735	COG1174	glycine betaine transport
CWR44_RS01755	COG1063	alcohol dehydrogenase
CWR44_RS01760	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CWR44_RS01765	COG0531	amino acid
CWR44_RS01770	COG2272	Belongs to the type-B carboxylesterase lipase family
CWR44_RS01775	COG2814	Major facilitator Superfamily
CWR44_RS01785	COG0745	RESPONSE REGULATOR receiver
CWR44_RS01790	COG2205	protein histidine kinase activity
CWR44_RS01795	COG0390	transport system, permease component
CWR44_RS01800	COG4619	ABC transporter
CWR44_RS01815	COG0069	glutamate synthase activity
CWR44_RS01830	COG1363	Peptidase, m42
CWR44_RS01835	COG1028	Short-chain dehydrogenase reductase Sdr
CWR44_RS01840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CWR44_RS01850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CWR44_RS01855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR44_RS01860	COG4221	oxidoreductase activity
CWR44_RS01885	COG0494	nUDIX hydrolase
CWR44_RS01890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWR44_RS01895	COG2610	gluconate transmembrane transporter activity
CWR44_RS01900	COG1070	Carbohydrate kinase
CWR44_RS01905	COG1802	Transcriptional regulator
CWR44_RS01920	COG2357	RelA SpoT domain protein
CWR44_RS01925	COG4876	unkown
CWR44_RS01940	COG2271	Major facilitator Superfamily
CWR44_RS01950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR44_RS01955	COG2022	thiamine diphosphate biosynthetic process
CWR44_RS01955	COG2104	thiamine diphosphate biosynthetic process
CWR44_RS01960	COG2022	thiamine diphosphate biosynthetic process
CWR44_RS01970	COG0586	Pfam SNARE associated Golgi protein
CWR44_RS01975	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CWR44_RS01985	COG3949	Membrane
CWR44_RS01990	COG0400	carboxylic ester hydrolase activity
CWR44_RS01995	COG0346	lactoylglutathione lyase activity
CWR44_RS02000	COG0346	lactoylglutathione lyase activity
CWR44_RS02005	COG1846	Transcriptional regulator
CWR44_RS02010	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS02025	COG2514	catechol 2,3-dioxygenase activity
CWR44_RS02035	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS02055	COG3764	Sortase (surface protein transpeptidase)
CWR44_RS02070	COG1760	l-serine dehydratase
CWR44_RS02075	COG1760	l-serine dehydratase
CWR44_RS02085	COG1070	Carbohydrate kinase
CWR44_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWR44_RS02115	COG2207	Transcriptional regulator
CWR44_RS02115	COG1917	Cupin 2, conserved barrel domain protein
CWR44_RS02125	COG0697	spore germination
CWR44_RS02135	COG0039	L-malate dehydrogenase activity
CWR44_RS02140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR44_RS02150	COG1063	alcohol dehydrogenase
CWR44_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS02155	COG2190	(PTS) system
CWR44_RS02155	COG1263	PTS System
CWR44_RS02165	COG0028	Belongs to the TPP enzyme family
CWR44_RS02170	COG1346	cytolysis
CWR44_RS02175	COG1380	Effector of murein hydrolase LrgA
CWR44_RS02180	COG0583	DNA-binding transcription factor activity
CWR44_RS02190	COG3942	CHAP domain
CWR44_RS02190	COG1388	LysM domain
CWR44_RS02205	COG3425	synthase
CWR44_RS02210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWR44_RS02220	COG0598	Magnesium transport protein CorA
CWR44_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS02245	COG0110	maltose O-acetyltransferase activity
CWR44_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
CWR44_RS02260	COG2217	Heavy metal translocating P-type atpase
CWR44_RS02265	COG2608	mercury ion transmembrane transporter activity
CWR44_RS02275	COG0436	Aminotransferase
CWR44_RS02280	COG1233	COG1233 Phytoene dehydrogenase and related
CWR44_RS02285	COG1562	ergosterol biosynthetic process
CWR44_RS02290	COG0463	Glycosyl transferase, family 2
CWR44_RS02295	COG1233	COG1233 Phytoene dehydrogenase and related
CWR44_RS02305	COG0741	lytic transglycosylase activity
CWR44_RS02330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWR44_RS02365	COG3001	Fructosamine kinase
CWR44_RS02370	COG0167	dihydroorotate dehydrogenase activity
CWR44_RS02380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWR44_RS02410	COG3527	Alpha-acetolactate decarboxylase
CWR44_RS02415	COG0028	Belongs to the TPP enzyme family
CWR44_RS02420	COG0531	amino acid
CWR44_RS02430	COG1464	Belongs to the NlpA lipoprotein family
CWR44_RS02460	COG0563	adenylate kinase activity
CWR44_RS02465	COG3588	fructose-bisphosphate aldolase
CWR44_RS02490	COG0579	oxidoreductase
CWR44_RS02495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWR44_RS02500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWR44_RS02500	COG0574	Belongs to the PEP-utilizing enzyme family
CWR44_RS02510	COG0583	DNA-binding transcription factor activity
CWR44_RS02520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR44_RS02535	COG1473	amidohydrolase
CWR44_RS02545	COG1473	amidohydrolase
CWR44_RS02555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CWR44_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS02565	COG1510	regulation of RNA biosynthetic process
CWR44_RS02570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWR44_RS02575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWR44_RS02590	COG2851	Citrate transporter
CWR44_RS02595	COG0529	Catalyzes the synthesis of activated sulfate
CWR44_RS02600	COG2046	Belongs to the sulfate adenylyltransferase family
CWR44_RS02605	COG0730	response to heat
CWR44_RS02620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWR44_RS02625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWR44_RS02630	COG0175	sulfate reduction
CWR44_RS02660	COG1136	(ABC) transporter
CWR44_RS02665	COG2205	protein histidine kinase activity
CWR44_RS02675	COG1785	Belongs to the alkaline phosphatase family
CWR44_RS02680	COG1316	TRANSCRIPTIONal
CWR44_RS02685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWR44_RS02690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWR44_RS02700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWR44_RS02705	COG0297	glycogen (starch) synthase activity
CWR44_RS02730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWR44_RS02770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWR44_RS02780	COG3961	Belongs to the TPP enzyme family
CWR44_RS02785	COG2843	Capsule synthesis protein
CWR44_RS02790	COG5658	integral membrane protein
CWR44_RS02840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWR44_RS02850	COG2235	arginine
CWR44_RS02885	COG3942	CHAP domain
CWR44_RS02885	COG3942	CHAP domain
CWR44_RS02885	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWR44_RS02885	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWR44_RS02890	COG2190	(PTS) system
CWR44_RS02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS02890	COG1263	PTS System
CWR44_RS02895	COG1288	antiporter activity
CWR44_RS02905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWR44_RS02910	COG0583	DNA-binding transcription factor activity
CWR44_RS02915	COG2409	Drug exporters of the RND superfamily
CWR44_RS02920	COG2113	Glycine betaine
CWR44_RS02930	COG2814	Major facilitator Superfamily
CWR44_RS02950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR44_RS02970	COG0745	RESPONSE REGULATOR receiver
CWR44_RS02975	COG0642	Histidine kinase
CWR44_RS02990	COG0653	protein targeting
CWR44_RS03000	COG1073	alpha beta
CWR44_RS03010	COG0201	protein transport
CWR44_RS03015	COG3391	amine dehydrogenase activity
CWR44_RS03040	COG3639	organic phosphonate transmembrane transporter activity
CWR44_RS03045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CWR44_RS03055	COG0737	Belongs to the 5'-nucleotidase family
CWR44_RS03065	COG2814	Major facilitator Superfamily
CWR44_RS03070	COG0697	spore germination
CWR44_RS03075	COG1959	2 iron, 2 sulfur cluster binding
CWR44_RS03080	COG1476	TRANSCRIPTIONal
CWR44_RS03090	COG1131	(ABC) transporter
CWR44_RS03110	COG4716	Myosin-crossreactive antigen
CWR44_RS03130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWR44_RS03135	COG3386	PFAM SMP-30 Gluconolaconase
CWR44_RS03140	COG1054	Belongs to the UPF0176 family
CWR44_RS03150	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CWR44_RS03170	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CWR44_RS03190	COG0444	Belongs to the ABC transporter superfamily
CWR44_RS03195	COG1124	(ABC) transporter
CWR44_RS03220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWR44_RS03225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR44_RS03240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CWR44_RS03245	COG0363	glucosamine-6-phosphate deaminase activity
CWR44_RS03255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWR44_RS03270	COG4336	lyase activity
CWR44_RS03275	COG5505	Protein of unknown function (DUF819)
CWR44_RS03280	COG0471	metal ion transport
CWR44_RS03290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWR44_RS03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWR44_RS03330	COG3093	addiction module antidote protein HigA
CWR44_RS03340	COG0549	Belongs to the carbamate kinase family
CWR44_RS03345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWR44_RS03355	COG2314	TM2 domain
CWR44_RS03375	COG0789	Transcriptional regulator
CWR44_RS03425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWR44_RS03435	COG2962	Rard protein
CWR44_RS03440	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CWR44_RS03455	COG1695	Transcriptional regulator
CWR44_RS03460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR44_RS03465	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR44_RS03470	COG0022	dehydrogenase e1 component
CWR44_RS03475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWR44_RS03480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR44_RS03490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWR44_RS03505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR44_RS03510	COG1846	Transcriptional regulator
CWR44_RS03515	COG1063	alcohol dehydrogenase
CWR44_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
CWR44_RS03565	COG2318	DinB family
CWR44_RS03580	COG1288	antiporter activity
CWR44_RS03585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CWR44_RS03595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWR44_RS03605	COG3152	Membrane
CWR44_RS03615	COG2971	BadF BadG BcrA BcrD
CWR44_RS03630	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWR44_RS03635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR44_RS03640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWR44_RS03645	COG1737	Transcriptional regulator
CWR44_RS03650	COG1876	peptidase activity
CWR44_RS03660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWR44_RS03665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWR44_RS03670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWR44_RS03680	COG1879	ABC-type sugar transport system periplasmic component
CWR44_RS03685	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWR44_RS03690	COG1129	ABC transporter
CWR44_RS03695	COG1869	D-ribose catabolic process
CWR44_RS03700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR44_RS03705	COG1609	Transcriptional regulator
CWR44_RS03750	COG0778	Nitroreductase
CWR44_RS03755	COG1113	amino acid transport
CWR44_RS03780	COG2910	NAD(P)H-binding
CWR44_RS03785	COG1959	2 iron, 2 sulfur cluster binding
CWR44_RS03790	COG1253	flavin adenine dinucleotide binding
CWR44_RS03800	COG0789	Transcriptional regulator
CWR44_RS03830	COG4172	Belongs to the ABC transporter superfamily
CWR44_RS03835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR44_RS03845	COG0747	negative chemotaxis
CWR44_RS03860	COG1114	Component of the transport system for branched-chain amino acids
CWR44_RS03865	COG0523	cobalamin synthesis protein
CWR44_RS03870	COG1121	(ABC) transporter
CWR44_RS03875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWR44_RS03880	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWR44_RS03890	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CWR44_RS03935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CWR44_RS03945	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWR44_RS03950	COG0523	cobalamin synthesis protein
CWR44_RS03965	COG0668	transmembrane transport
CWR44_RS03980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CWR44_RS03985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWR44_RS03990	COG0640	Transcriptional regulator
CWR44_RS04005	COG2130	NADP-dependent
CWR44_RS04010	COG0702	epimerase
CWR44_RS04020	COG0789	Transcriptional regulator
CWR44_RS04045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CWR44_RS04050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CWR44_RS04055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CWR44_RS04065	COG2205	protein histidine kinase activity
CWR44_RS04070	COG0745	RESPONSE REGULATOR receiver
CWR44_RS04105	COG1105	Belongs to the carbohydrate kinase PfkB family
CWR44_RS04115	COG1397	ADP-ribosylglycohydrolase
CWR44_RS04120	COG1388	LysM domain
CWR44_RS04130	COG0730	response to heat
CWR44_RS04135	COG1937	Protein conserved in bacteria
CWR44_RS04140	COG2210	Belongs to the sulfur carrier protein TusA family
CWR44_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR44_RS04150	COG2217	Heavy metal translocating P-type atpase
CWR44_RS04160	COG0640	Transcriptional regulator
CWR44_RS04185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWR44_RS04285	COG2030	dehydratase
CWR44_RS04290	COG0584	glycerophosphoryl diester phosphodiesterase
CWR44_RS04300	COG3425	synthase
CWR44_RS04310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR44_RS04310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR44_RS04330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWR44_RS04335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWR44_RS04345	COG4863	YycH protein
CWR44_RS04350	COG5002	protein histidine kinase activity
CWR44_RS04355	COG0745	RESPONSE REGULATOR receiver
CWR44_RS04370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWR44_RS04375	COG0305	Participates in initiation and elongation during chromosome replication
CWR44_RS04380	COG0359	binds to the 23S rRNA
CWR44_RS04385	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CWR44_RS04395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWR44_RS04405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWR44_RS04410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWR44_RS04415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWR44_RS04420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWR44_RS04425	COG0187	DNA topoisomerase II activity
CWR44_RS04430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWR44_RS04435	COG2501	S4 domain
CWR44_RS04440	COG0592	DNA-directed DNA polymerase activity
CWR44_RS04445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWR44_RS04455	COG0594	ribonuclease P activity
CWR44_RS04460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWR44_RS04465	COG0445	tRNA wobble uridine modification
CWR44_RS04470	COG0357	Ribosomal RNA small subunit methyltransferase G
CWR44_RS04510	COG0577	efflux transmembrane transporter activity
CWR44_RS04515	COG1136	(ABC) transporter
CWR44_RS04540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWR44_RS04545	COG0346	lactoylglutathione lyase activity
CWR44_RS04555	COG0488	(ABC) transporter
CWR44_RS04570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWR44_RS04575	COG0646	methionine synthase
CWR44_RS04575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CWR44_RS04580	COG0626	cystathionine gamma-synthase activity
CWR44_RS04585	COG0626	cystathionine gamma-synthase activity
CWR44_RS04590	COG1475	DNA binding
CWR44_RS04595	COG0668	transmembrane transport
CWR44_RS04600	COG4481	Protein conserved in bacteria
CWR44_RS04605	COG0012	GTP binding
CWR44_RS04620	COG0360	Binds together with S18 to 16S ribosomal RNA
CWR44_RS04630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWR44_RS04670	COG0745	RESPONSE REGULATOR receiver
CWR44_RS04675	COG5002	protein histidine kinase activity
CWR44_RS04690	COG0693	protein deglycase activity
CWR44_RS04695	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CWR44_RS04700	COG1733	regulation of RNA biosynthetic process
CWR44_RS04705	COG0579	oxidoreductase
CWR44_RS04740	COG0456	acetyltransferase
CWR44_RS04765	COG1902	pentaerythritol trinitrate reductase activity
CWR44_RS04775	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS04785	COG3682	Transcriptional regulator
CWR44_RS04850	COG1280	lysine exporter protein (LysE YggA)
CWR44_RS04855	COG0406	alpha-ribazole phosphatase activity
CWR44_RS04865	COG3634	alkyl hydroperoxide reductase activity
CWR44_RS04870	COG0450	alkyl hydroperoxide reductase
CWR44_RS04880	COG0778	Nitroreductase
CWR44_RS04885	COG1823	symporter activity
CWR44_RS04905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR44_RS04910	COG2233	PERMEase
CWR44_RS04915	COG0516	GMP reductase activity
CWR44_RS04915	COG0517	IMP dehydrogenase activity
CWR44_RS04920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWR44_RS04920	COG0519	Catalyzes the synthesis of GMP from XMP
CWR44_RS05015	COG3728	DNA packaging
CWR44_RS05015	COG5484	DNA packaging
CWR44_RS05030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWR44_RS05045	COG3759	membrane
CWR44_RS05055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWR44_RS05060	COG3002	Belongs to the UPF0753 family
CWR44_RS05065	COG5609	conserved protein (DUF2294)
CWR44_RS05075	COG0671	phosphoesterase, PA-phosphatase related
CWR44_RS05085	COG1647	Serine aminopeptidase, S33
CWR44_RS05100	COG0733	neurotransmitter:sodium symporter activity
CWR44_RS05115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWR44_RS05120	COG0626	cystathionine gamma-synthase activity
CWR44_RS05125	COG1388	LysM domain
CWR44_RS05125	COG3942	CHAP domain
CWR44_RS05160	COG0067	glutamate synthase
CWR44_RS05160	COG0069	glutamate synthase activity
CWR44_RS05160	COG0070	glutamate synthase
CWR44_RS05165	COG0493	'glutamate synthase
CWR44_RS05175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS05175	COG1263	PTS System
CWR44_RS05180	COG0366	Alpha amylase catalytic
CWR44_RS05185	COG2188	Transcriptional regulator
CWR44_RS05200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWR44_RS05210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWR44_RS05235	COG1982	Orn Lys Arg decarboxylase major
CWR44_RS05240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWR44_RS05245	COG3870	Protein conserved in bacteria
CWR44_RS05250	COG0470	DNA polymerase III
CWR44_RS05255	COG1774	PSP1 C-terminal conserved region
CWR44_RS05260	COG4467	Involved in initiation control of chromosome replication
CWR44_RS05265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWR44_RS05270	COG2827	Endonuclease containing a URI domain
CWR44_RS05275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWR44_RS05280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR44_RS05280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR44_RS05285	COG0084	hydrolase, TatD family'
CWR44_RS05290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CWR44_RS05295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWR44_RS05300	COG4466	Protein conserved in bacteria
CWR44_RS05305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWR44_RS05310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR44_RS05315	COG0251	oxidation-reduction process
CWR44_RS05320	COG2088	sporulation resulting in formation of a cellular spore
CWR44_RS05325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWR44_RS05330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CWR44_RS05335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWR44_RS05340	COG0193	aminoacyl-tRNA hydrolase activity
CWR44_RS05345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWR44_RS05350	COG2244	polysaccharide biosynthetic process
CWR44_RS05355	COG3956	TIGRFAM MazG family protein
CWR44_RS05360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWR44_RS05370	COG1098	S1 RNA binding domain
CWR44_RS05375	COG0037	tRNA processing
CWR44_RS05385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR44_RS05390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWR44_RS05395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWR44_RS05410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWR44_RS05415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWR44_RS05500	COG2259	Doxx family
CWR44_RS05505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR44_RS05510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWR44_RS05515	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWR44_RS05520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CWR44_RS05525	COG4463	regulation of RNA biosynthetic process
CWR44_RS05530	COG3880	PFAM UvrB UvrC protein
CWR44_RS05535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CWR44_RS05540	COG0542	response to heat
CWR44_RS05545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CWR44_RS05550	COG4956	integral membrane protein (PIN domain superfamily)
CWR44_RS05555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWR44_RS05560	COG1045	serine acetyltransferase
CWR44_RS05565	COG0215	cysteine-tRNA ligase activity
CWR44_RS05570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CWR44_RS05575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR44_RS05580	COG3688	RNA-binding protein containing a PIN domain
CWR44_RS05590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWR44_RS05595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWR44_RS05600	COG0250	Participates in transcription elongation, termination and antitermination
CWR44_RS05605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWR44_RS05610	COG0081	regulation of translation
CWR44_RS05620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWR44_RS05625	COG0222	ribosome binding
CWR44_RS05630	COG2813	Specifically methylates the guanine in position
CWR44_RS05635	COG0085	RNA polymerase activity
CWR44_RS05640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWR44_RS05650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWR44_RS05660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWR44_RS05665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWR44_RS05670	COG1473	amidohydrolase
CWR44_RS05695	COG0737	Belongs to the 5'-nucleotidase family
CWR44_RS05700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR44_RS05705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWR44_RS05745	COG0546	phosphoglycolate phosphatase activity
CWR44_RS05750	COG1428	Deoxynucleoside kinase
CWR44_RS05755	COG1428	Deoxynucleoside kinase
CWR44_RS05765	COG0561	phosphatase activity
CWR44_RS05770	COG0431	NADPH-dependent FMN reductase
CWR44_RS05835	COG1469	GTP cyclohydrolase I activity
CWR44_RS05840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWR44_RS05850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CWR44_RS05855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CWR44_RS05860	COG0318	PFAM AMP-dependent synthetase and ligase
CWR44_RS05865	COG0183	Belongs to the thiolase family
CWR44_RS05880	COG0477	Major facilitator Superfamily
CWR44_RS05890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWR44_RS05900	COG2363	Small membrane protein
CWR44_RS05915	COG2966	Psort location CytoplasmicMembrane, score
CWR44_RS05920	COG3253	May function as heme-dependent peroxidase
CWR44_RS05930	COG0095	Lipoate-protein ligase
CWR44_RS05955	COG4844	belongs to the
CWR44_RS05960	COG1278	Cold shock
CWR44_RS05965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR44_RS05975	COG0667	Aldo Keto reductase
CWR44_RS05980	COG0655	NAD(P)H dehydrogenase (quinone) activity
CWR44_RS05990	COG1078	dGTPase activity
CWR44_RS06010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR44_RS06025	COG0583	DNA-binding transcription factor activity
CWR44_RS06035	COG0579	oxidoreductase
CWR44_RS06055	COG0018	arginyl-trna synthetase
CWR44_RS06060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWR44_RS06075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWR44_RS06080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS06145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWR44_RS06145	COG2111	Na H antiporter
CWR44_RS06150	COG2111	Na H antiporter
CWR44_RS06155	COG1006	Multisubunit Na H antiporter MnhC subunit
CWR44_RS06160	COG0651	ATP synthesis coupled electron transport
CWR44_RS06165	COG1863	multisubunit Na H antiporter MnhE subunit
CWR44_RS06170	COG2212	antiporter activity
CWR44_RS06175	COG1320	monovalent cation:proton antiporter activity
CWR44_RS06200	COG1321	iron dependent repressor
CWR44_RS06210	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CWR44_RS06215	COG1134	teichoic acid transport
CWR44_RS06220	COG1682	transport, permease protein
CWR44_RS06225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWR44_RS06235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWR44_RS06240	COG1686	Belongs to the peptidase S11 family
CWR44_RS06245	COG1132	(ABC) transporter
CWR44_RS06255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWR44_RS06255	COG0463	Glycosyl transferase, family 2
CWR44_RS06260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CWR44_RS06265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWR44_RS06270	COG1120	ATPase activity
CWR44_RS06275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS06280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS06285	COG2376	Dihydroxyacetone kinase
CWR44_RS06295	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CWR44_RS06305	COG3949	Membrane
CWR44_RS06310	COG0657	acetylesterase activity
CWR44_RS06320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR44_RS06325	COG0745	RESPONSE REGULATOR receiver
CWR44_RS06330	COG2205	protein histidine kinase activity
CWR44_RS06335	COG1136	(ABC) transporter
CWR44_RS06340	COG0577	efflux transmembrane transporter activity
CWR44_RS06345	COG1392	Phosphate transport regulator
CWR44_RS06350	COG0306	phosphate transporter
CWR44_RS06355	COG3942	CHAP domain
CWR44_RS06355	COG1388	LysM domain
CWR44_RS06375	COG0217	transcriptional regulatory protein
CWR44_RS06385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CWR44_RS06395	COG0583	DNA-binding transcription factor activity
CWR44_RS06405	COG2839	Protein conserved in bacteria
CWR44_RS06415	COG0456	acetyltransferase
CWR44_RS06430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWR44_RS06435	COG1611	Belongs to the LOG family
CWR44_RS06440	COG1671	Belongs to the UPF0178 family
CWR44_RS06450	COG1968	undecaprenyl-diphosphatase activity
CWR44_RS06455	COG4988	ABC transporter
CWR44_RS06460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWR44_RS06470	COG0523	cobalamin synthesis protein
CWR44_RS06480	COG0471	metal ion transport
CWR44_RS06485	COG0415	Belongs to the DNA photolyase family
CWR44_RS06520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWR44_RS06525	COG1349	DNA-binding transcription factor activity
CWR44_RS06530	COG1105	Belongs to the carbohydrate kinase PfkB family
CWR44_RS06535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR44_RS06535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR44_RS06535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWR44_RS06540	COG1253	flavin adenine dinucleotide binding
CWR44_RS06545	COG0656	L-ascorbic acid biosynthetic process
CWR44_RS06555	COG0463	Glycosyl transferase, family 2
CWR44_RS06565	COG0602	queuosine metabolic process
CWR44_RS06570	COG0720	synthase
CWR44_RS06580	COG0512	Glutamine amidotransferase of anthranilate synthase
CWR44_RS06580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWR44_RS06600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWR44_RS06605	COG1984	allophanate hydrolase subunit 2
CWR44_RS06610	COG1368	sulfuric ester hydrolase activity
CWR44_RS06625	COG0488	(ABC) transporter
CWR44_RS06630	COG0514	ATP-dependent DNA helicase (RecQ)
CWR44_RS06640	COG1174	glycine betaine transport
CWR44_RS06645	COG3104	oligopeptide transport
CWR44_RS06650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWR44_RS06660	COG1597	lipid kinase activity
CWR44_RS06670	COG3104	oligopeptide transport
CWR44_RS06675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWR44_RS06685	COG1780	Probably involved in ribonucleotide reductase function
CWR44_RS06690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWR44_RS06695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWR44_RS06700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR44_RS06705	COG4605	iron ion homeostasis
CWR44_RS06710	COG4604	ABC transporter, ATP-binding protein
CWR44_RS06715	COG4607	ABC-type enterochelin transport system periplasmic component
CWR44_RS06730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWR44_RS06750	COG1929	Belongs to the glycerate kinase type-1 family
CWR44_RS06755	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR44_RS06770	COG2199	diguanylate cyclase activity
CWR44_RS06775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWR44_RS06780	COG1739	Uncharacterized protein family UPF0029
CWR44_RS06790	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CWR44_RS06795	COG1040	competence protein
CWR44_RS06800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWR44_RS06805	COG0653	protein targeting
CWR44_RS06815	COG1388	LysM domain
CWR44_RS06815	COG3942	CHAP domain
CWR44_RS06820	COG0300	oxidoreductase activity
CWR44_RS06835	COG0556	nucleotide-excision repair
CWR44_RS06840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWR44_RS06845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CWR44_RS06850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWR44_RS06865	COG0492	ferredoxin-NADP+ reductase activity
CWR44_RS06870	COG1660	Displays ATPase and GTPase activities
CWR44_RS06875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CWR44_RS06880	COG1481	regulation of sporulation
CWR44_RS06890	COG0740	serine-type endopeptidase activity
CWR44_RS06900	COG1090	epimerase
CWR44_RS06920	COG2390	Transcriptional regulator
CWR44_RS06930	COG0126	phosphoglycerate kinase activity
CWR44_RS06935	COG0149	triose-phosphate isomerase activity
CWR44_RS06940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CWR44_RS06945	COG0148	phosphopyruvate hydratase activity
CWR44_RS06955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWR44_RS06960	COG1647	Serine aminopeptidase, S33
CWR44_RS06965	COG0557	exoribonuclease II activity
CWR44_RS06970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWR44_RS07000	COG4195	phage-related replication protein
CWR44_RS07005	COG0456	acetyltransferase
CWR44_RS07050	COG0406	alpha-ribazole phosphatase activity
CWR44_RS07055	COG1279	arginine transmembrane transporter activity
CWR44_RS07070	COG1764	response to oxidative stress
CWR44_RS07075	COG0710	3-dehydroquinate dehydratase activity
CWR44_RS07085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR44_RS07090	COG1393	Belongs to the ArsC family
CWR44_RS07095	COG0509	glycine decarboxylation via glycine cleavage system
CWR44_RS07100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CWR44_RS07110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWR44_RS07115	COG2011	ABC-type metal ion transport system permease component
CWR44_RS07120	COG1464	Belongs to the NlpA lipoprotein family
CWR44_RS07125	COG3237	CsbD-like
CWR44_RS07140	COG0396	ATPase activity
CWR44_RS07145	COG0719	Fe-S assembly protein
CWR44_RS07155	COG0822	iron-sulfur transferase activity
CWR44_RS07160	COG0719	Fe-S assembly protein
CWR44_RS07170	COG2070	2-Nitropropane dioxygenase
CWR44_RS07175	COG1801	Protein of unknown function DUF72
CWR44_RS07180	COG0730	response to heat
CWR44_RS07185	COG0737	Belongs to the 5'-nucleotidase family
CWR44_RS07190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWR44_RS07195	COG4470	Protein conserved in bacteria
CWR44_RS07205	COG2445	Protein of unknown function DUF86
CWR44_RS07210	COG0647	UMP catabolic process
CWR44_RS07225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWR44_RS07230	COG1696	Membrane protein involved in D-alanine export
CWR44_RS07235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR44_RS07240	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CWR44_RS07245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWR44_RS07250	COG4837	Protein of unknown function (DUF1462)
CWR44_RS07255	COG1252	NADH dehydrogenase
CWR44_RS07260	COG4844	belongs to the
CWR44_RS07265	COG0316	Belongs to the HesB IscA family
CWR44_RS07270	COG1252	NADH dehydrogenase
CWR44_RS07275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWR44_RS07280	COG2056	Na+-H+ antiporter family
CWR44_RS07285	COG2050	protein possibly involved in aromatic compounds catabolism
CWR44_RS07295	COG1320	monovalent cation:proton antiporter activity
CWR44_RS07300	COG2212	antiporter activity
CWR44_RS07305	COG1863	multisubunit Na H antiporter MnhE subunit
CWR44_RS07310	COG0651	ATP synthesis coupled electron transport
CWR44_RS07315	COG1006	Multisubunit Na H antiporter MnhC subunit
CWR44_RS07320	COG2111	Na H antiporter
CWR44_RS07325	COG2111	Na H antiporter
CWR44_RS07325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWR44_RS07335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWR44_RS07340	COG1098	S1 RNA binding domain
CWR44_RS07350	COG1902	pentaerythritol trinitrate reductase activity
CWR44_RS07365	COG0584	glycerophosphoryl diester phosphodiesterase
CWR44_RS07370	COG0165	Argininosuccinate lyase
CWR44_RS07375	COG0137	argininosuccinate synthase activity
CWR44_RS07380	COG0166	Belongs to the GPI family
CWR44_RS07385	COG0398	Pfam SNARE associated Golgi protein
CWR44_RS07400	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CWR44_RS07405	COG1074	ATP-dependent DNA helicase activity
CWR44_RS07410	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR44_RS07425	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR44_RS07430	COG0561	phosphatase activity
CWR44_RS07445	COG0542	response to heat
CWR44_RS07455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWR44_RS07470	COG0601	transmembrane transport
CWR44_RS07475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR44_RS07480	COG0444	Belongs to the ABC transporter superfamily
CWR44_RS07485	COG4608	Belongs to the ABC transporter superfamily
CWR44_RS07490	COG4166	transmembrane transport
CWR44_RS07500	COG0180	Tryptophanyl-tRNA synthetase
CWR44_RS07505	COG1393	Belongs to the ArsC family
CWR44_RS07510	COG4862	establishment of competence for transformation
CWR44_RS07520	COG1164	Oligoendopeptidase f
CWR44_RS07525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWR44_RS07530	COG2346	COG2346, Truncated hemoglobins
CWR44_RS07535	COG4116	CYTH
CWR44_RS07545	COG2357	RelA SpoT domain protein
CWR44_RS07550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWR44_RS07555	COG0564	pseudouridine synthase activity
CWR44_RS07560	COG2239	Acts as a magnesium transporter
CWR44_RS07565	COG0569	domain protein
CWR44_RS07565	COG0475	glutathione-regulated potassium exporter activity
CWR44_RS07575	COG0628	permease
CWR44_RS07580	COG2382	esterase
CWR44_RS07585	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CWR44_RS07590	COG2814	Major facilitator Superfamily
CWR44_RS07595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR44_RS07600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWR44_RS07610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CWR44_RS07615	COG0861	Integral membrane protein TerC family
CWR44_RS07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWR44_RS07625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWR44_RS07640	COG4873	Protein conserved in bacteria
CWR44_RS07700	COG1575	Belongs to the MenA family. Type 1 subfamily
CWR44_RS07705	COG1169	isochorismate synthase
CWR44_RS07710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWR44_RS07715	COG0596	Alpha beta hydrolase
CWR44_RS07720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWR44_RS07730	COG0436	Aminotransferase
CWR44_RS07735	COG3594	Acyltransferase
CWR44_RS07765	COG1316	TRANSCRIPTIONal
CWR44_RS07770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CWR44_RS07780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWR44_RS07785	COG1845	cytochrome c oxidase, subunit III
CWR44_RS07790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWR44_RS07795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWR44_RS07820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWR44_RS07825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWR44_RS07830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWR44_RS07835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWR44_RS07840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWR44_RS07845	COG0047	phosphoribosylformylglycinamidine synthase activity
CWR44_RS07850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWR44_RS07860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWR44_RS07870	COG0138	bifunctional purine biosynthesis protein purh
CWR44_RS07875	COG0151	Belongs to the GarS family
CWR44_RS07880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWR44_RS07885	COG1122	ATPase activity
CWR44_RS07905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CWR44_RS07920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWR44_RS07940	COG1271	oxidase subunit
CWR44_RS07945	COG1294	oxidase, subunit
CWR44_RS07950	COG0569	domain protein
CWR44_RS07955	COG2832	Protein of unknown function (DUF454)
CWR44_RS07965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWR44_RS07970	COG5503	Protein of unknown function (DUF1447)
CWR44_RS07975	COG0242	peptide deformylase activity
CWR44_RS08005	COG4476	Belongs to the UPF0223 family
CWR44_RS08010	COG1396	sequence-specific DNA binding
CWR44_RS08010	COG3800	Transcriptional regulator
CWR44_RS08015	COG3842	ATPase activity
CWR44_RS08020	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWR44_RS08025	COG1177	transmembrane transport
CWR44_RS08045	COG1914	H( )-stimulated, divalent metal cation uptake system
CWR44_RS08050	COG4493	Belongs to the UPF0637 family
CWR44_RS08055	COG0483	inositol monophosphate 1-phosphatase activity
CWR44_RS08065	COG1217	gtp-binding protein TYPA
CWR44_RS08070	COG4896	Protein conserved in bacteria
CWR44_RS08075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWR44_RS08080	COG4838	Belongs to the UPF0358 family
CWR44_RS08085	COG0772	Belongs to the SEDS family
CWR44_RS08095	COG1612	heme a metabolic process
CWR44_RS08100	COG0109	protoheme IX farnesyltransferase activity
CWR44_RS08110	COG2340	Cysteine-rich secretory protein family
CWR44_RS08115	COG3679	Belongs to the UPF0342 family
CWR44_RS08125	COG4471	UPF0298 protein
CWR44_RS08135	COG0742	ribosomal rna small subunit methyltransferase
CWR44_RS08140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWR44_RS08145	COG1323	Belongs to the UPF0348 family
CWR44_RS08160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWR44_RS08165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR44_RS08170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWR44_RS08175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR44_RS08175	COG0072	phenylalanine-tRNA ligase activity
CWR44_RS08180	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWR44_RS08185	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CWR44_RS08195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWR44_RS08195	COG1796	DNA polymerase
CWR44_RS08200	COG1193	negative regulation of DNA recombination
CWR44_RS08205	COG3118	belongs to the thioredoxin family
CWR44_RS08210	COG0322	excinuclease ABC activity
CWR44_RS08215	COG2009	succinate dehydrogenase
CWR44_RS08220	COG1053	succinate dehydrogenase
CWR44_RS08225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWR44_RS08235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWR44_RS08240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWR44_RS08280	COG1011	Hydrolase
CWR44_RS08285	COG0454	-acetyltransferase
CWR44_RS08290	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CWR44_RS08295	COG2001	Belongs to the MraZ family
CWR44_RS08300	COG0275	rRNA processing
CWR44_RS08305	COG4839	cell division protein FtsL
CWR44_RS08310	COG0768	penicillin binding
CWR44_RS08315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWR44_RS08320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWR44_RS08325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWR44_RS08330	COG0849	cell division
CWR44_RS08335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWR44_RS08340	COG1496	oxidoreductase activity
CWR44_RS08345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWR44_RS08350	COG1799	cell septum assembly
CWR44_RS08355	COG0762	integral membrane protein
CWR44_RS08365	COG3599	regulation of cell shape
CWR44_RS08370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWR44_RS08375	COG0702	epimerase
CWR44_RS08385	COG1388	LysM domain
CWR44_RS08385	COG3942	CHAP domain
CWR44_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWR44_RS08395	COG0564	pseudouridine synthase activity
CWR44_RS08400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWR44_RS08405	COG2233	PERMEase
CWR44_RS08410	COG0540	Belongs to the ATCase OTCase family
CWR44_RS08420	COG0505	Belongs to the CarA family
CWR44_RS08425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWR44_RS08430	COG0284	orotidine-5'-phosphate decarboxylase activity
CWR44_RS08435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWR44_RS08455	COG0194	GDP metabolic process
CWR44_RS08460	COG1758	RNA polymerase activity
CWR44_RS08465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWR44_RS08470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWR44_RS08485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWR44_RS08490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR44_RS08490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWR44_RS08495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWR44_RS08500	COG0631	protein serine/threonine phosphatase activity
CWR44_RS08510	COG1162	GTPase activity
CWR44_RS08515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWR44_RS08520	COG1564	THIamine pyrophosphokinase
CWR44_RS08525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWR44_RS08530	COG1302	Protein conserved in bacteria
CWR44_RS08535	COG1461	Dihydroxyacetone kinase
CWR44_RS08550	COG1349	DNA-binding transcription factor activity
CWR44_RS08555	COG0416	fatty acid biosynthetic process
CWR44_RS08565	COG1028	Short-chain dehydrogenase reductase Sdr
CWR44_RS08570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR44_RS08575	COG0571	ribonuclease III activity
CWR44_RS08580	COG1196	nuclear chromosome segregation
CWR44_RS08585	COG0552	protein localization to endoplasmic reticulum
CWR44_RS08590	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CWR44_RS08595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWR44_RS08600	COG0228	four-way junction DNA binding
CWR44_RS08605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWR44_RS08610	COG0336	Belongs to the RNA methyltransferase TrmD family
CWR44_RS08615	COG0335	large ribosomal subunit rRNA binding
CWR44_RS08625	COG4485	Bacterial membrane protein, YfhO
CWR44_RS08635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWR44_RS08640	COG0045	succinate-CoA ligase (ADP-forming) activity
CWR44_RS08645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CWR44_RS08655	COG0758	DNA mediated transformation
CWR44_RS08660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWR44_RS08665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CWR44_RS08670	COG4974	Belongs to the 'phage' integrase family
CWR44_RS08675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CWR44_RS08680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CWR44_RS08685	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWR44_RS08690	COG0052	Belongs to the universal ribosomal protein uS2 family
CWR44_RS08695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWR44_RS08700	COG0528	UMP kinase activity
CWR44_RS08705	COG0233	cytoplasmic translational termination
CWR44_RS08710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWR44_RS08715	COG4589	Belongs to the CDS family
CWR44_RS08725	COG0442	prolyl-tRNA aminoacylation
CWR44_RS08730	COG2176	DNA-directed DNA polymerase activity
CWR44_RS08735	COG0779	Required for maturation of 30S ribosomal subunits
CWR44_RS08740	COG0195	Participates in both transcription termination and antitermination
CWR44_RS08745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CWR44_RS08750	COG1358	cellular component organization or biogenesis
CWR44_RS08755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWR44_RS08760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWR44_RS08765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWR44_RS08770	COG0196	riboflavin kinase activity
CWR44_RS08775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWR44_RS08780	COG1185	polyribonucleotide nucleotidyltransferase activity
CWR44_RS08785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWR44_RS08790	COG1674	ftsk spoiiie
CWR44_RS08795	COG2188	Transcriptional regulator
CWR44_RS08800	COG0612	Peptidase, M16
CWR44_RS08805	COG0612	Peptidase, M16
CWR44_RS08810	COG0300	oxidoreductase activity
CWR44_RS08830	COG1546	Belongs to the CinA family
CWR44_RS08830	COG1058	Belongs to the CinA family
CWR44_RS08835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWR44_RS08840	COG1418	mRNA catabolic process
CWR44_RS08850	COG1692	metallophosphoesterase
CWR44_RS08855	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWR44_RS08855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWR44_RS08860	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWR44_RS08865	COG4195	phage-related replication protein
CWR44_RS08875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR44_RS08880	COG4550	Control of competence regulator ComK, YlbF/YmcA
CWR44_RS08890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWR44_RS08895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWR44_RS08905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWR44_RS08910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWR44_RS08915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWR44_RS08925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWR44_RS08930	COG1923	regulation of RNA biosynthetic process
CWR44_RS08935	COG0386	Belongs to the glutathione peroxidase family
CWR44_RS08940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWR44_RS08945	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CWR44_RS08950	COG0789	Transcriptional regulator
CWR44_RS09035	COG0305	Participates in initiation and elongation during chromosome replication
CWR44_RS09130	COG0740	serine-type endopeptidase activity
CWR44_RS09175	COG3953	SLT domain
CWR44_RS09175	COG5412	phage tail tape measure protein
CWR44_RS09210	COG4824	toxin secretion phage lysis holin
CWR44_RS09280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR44_RS09285	COG1131	(ABC) transporter
CWR44_RS09295	COG4585	Histidine kinase
CWR44_RS09300	COG2197	response regulator
CWR44_RS09330	COG0527	aspartate kinase activity
CWR44_RS09335	COG0460	homoserine dehydrogenase
CWR44_RS09340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWR44_RS09345	COG0083	homoserine kinase activity
CWR44_RS09360	COG0833	amino acid
CWR44_RS09365	COG0753	catalase activity
CWR44_RS09375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWR44_RS09380	COG0516	GMP reductase activity
CWR44_RS09385	COG2340	Cysteine-rich secretory protein family
CWR44_RS09390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWR44_RS09400	COG4224	UPF0291 protein
CWR44_RS09410	COG3763	UPF0154 protein
CWR44_RS09415	COG0582	viral genome integration into host DNA
CWR44_RS09450	COG5377	YqaJ viral recombinase family
CWR44_RS09455	COG3723	Recombinational DNA repair protein, rece pathway
CWR44_RS09485	COG0305	Participates in initiation and elongation during chromosome replication
CWR44_RS09585	COG3331	DNA recombination
CWR44_RS09595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWR44_RS09610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CWR44_RS09615	COG0720	synthase
CWR44_RS09620	COG0602	queuosine metabolic process
CWR44_RS09625	COG0302	gtp cyclohydrolase
CWR44_RS09710	COG0739	heme binding
CWR44_RS09750	COG4846	Membrane protein involved in cytochrome C biogenesis
CWR44_RS09755	COG0420	3'-5' exonuclease activity
CWR44_RS09760	COG0419	ATPase involved in DNA repair
CWR44_RS09765	COG1970	mechanosensitive ion channel activity
CWR44_RS09770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWR44_RS09775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWR44_RS09780	COG0824	Thioesterase
CWR44_RS09785	COG4841	protein insertion into membrane
CWR44_RS09790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWR44_RS09795	COG0187	DNA topoisomerase II activity
CWR44_RS09800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWR44_RS09805	COG1115	amino acid carrier protein
CWR44_RS09810	COG3711	transcriptional antiterminator
CWR44_RS09815	COG0628	permease
CWR44_RS09820	COG0392	lysyltransferase activity
CWR44_RS09820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CWR44_RS09835	COG1942	4-Oxalocrotonate Tautomerase
CWR44_RS09840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWR44_RS09845	COG0287	Prephenate dehydrogenase
CWR44_RS09850	COG1363	Peptidase, m42
CWR44_RS09855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWR44_RS09860	COG0512	Glutamine amidotransferase of anthranilate synthase
CWR44_RS09865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWR44_RS09870	COG0134	indole-3-glycerol-phosphate synthase activity
CWR44_RS09875	COG0135	phosphoribosylanthranilate isomerase activity
CWR44_RS09885	COG0159	tryptophan synthase activity
CWR44_RS09895	COG2348	transferase activity, transferring amino-acyl groups
CWR44_RS09900	COG2348	transferase activity, transferring amino-acyl groups
CWR44_RS09905	COG0561	phosphatase activity
CWR44_RS09910	COG4607	ABC-type enterochelin transport system periplasmic component
CWR44_RS09920	COG1164	Oligoendopeptidase f
CWR44_RS09925	COG0704	Plays a role in the regulation of phosphate uptake
CWR44_RS09930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWR44_RS09935	COG0581	inorganic phosphate transmembrane transporter activity
CWR44_RS09940	COG0573	inorganic phosphate transmembrane transporter activity
CWR44_RS09945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWR44_RS09950	COG2996	Protein conserved in bacteria
CWR44_RS09955	COG0488	(ABC) transporter
CWR44_RS09965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWR44_RS09970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR44_RS09975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWR44_RS09980	COG2171	N-acyltransferase activity
CWR44_RS09985	COG1473	amidohydrolase
CWR44_RS10005	COG1278	Cold shock
CWR44_RS10015	COG1254	Belongs to the acylphosphatase family
CWR44_RS10025	COG3853	Toxic anion resistance protein (TelA)
CWR44_RS10030	COG1114	Component of the transport system for branched-chain amino acids
CWR44_RS10035	COG4548	von Willebrand factor, type A
CWR44_RS10040	COG0714	Associated with various cellular activities
CWR44_RS10060	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR44_RS10065	COG0567	Dehydrogenase, E1 component
CWR44_RS10070	COG5002	protein histidine kinase activity
CWR44_RS10075	COG0745	RESPONSE REGULATOR receiver
CWR44_RS10080	COG0671	phosphoesterase, PA-phosphatase related
CWR44_RS10085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWR44_RS10095	COG0793	Belongs to the peptidase S41A family
CWR44_RS10100	COG4479	Belongs to the UPF0346 family
CWR44_RS10105	COG2190	(PTS) system
CWR44_RS10110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR44_RS10130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWR44_RS10140	COG1413	lyase activity
CWR44_RS10145	COG1413	lyase activity
CWR44_RS10155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CWR44_RS10175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR44_RS10180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWR44_RS10190	COG0116	Belongs to the methyltransferase superfamily
CWR44_RS10200	COG3599	regulation of cell shape
CWR44_RS10205	COG4474	Belongs to the UPF0398 family
CWR44_RS10215	COG3331	DNA recombination
CWR44_RS10220	COG4499	WXG100 protein secretion system (Wss), protein YukC
CWR44_RS10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWR44_RS10230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWR44_RS10235	COG3935	DnaD domain protein
CWR44_RS10240	COG0017	Asparaginyl-tRNA synthetase
CWR44_RS10245	COG1199	ATP-dependent helicase activity
CWR44_RS10245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWR44_RS10255	COG0617	tRNA 3'-terminal CCA addition
CWR44_RS10260	COG0438	transferase activity, transferring glycosyl groups
CWR44_RS10265	COG1694	Mazg nucleotide pyrophosphohydrolase
CWR44_RS10270	COG2738	Putative neutral zinc metallopeptidase
CWR44_RS10275	COG4347	Protein of unknown function (DUF1405)
CWR44_RS10280	COG5582	Belongs to the UPF0302 family
CWR44_RS10285	COG0457	Tetratricopeptide repeat
CWR44_RS10290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWR44_RS10295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWR44_RS10300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWR44_RS10305	COG0105	UTP biosynthetic process
CWR44_RS10310	COG0142	geranyltranstransferase activity
CWR44_RS10315	COG2226	methyltransferase
CWR44_RS10330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWR44_RS10335	COG1160	GTP binding
CWR44_RS10340	COG0539	negative regulation of cytoplasmic translation
CWR44_RS10345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWR44_RS10355	COG0492	ferredoxin-NADP+ reductase activity
CWR44_RS10360	COG1388	LysM domain
CWR44_RS10365	COG0514	ATP-dependent DNA helicase (RecQ)
CWR44_RS10375	COG1141	Ferredoxin
CWR44_RS10390	COG0745	RESPONSE REGULATOR receiver
CWR44_RS10395	COG1187	pseudouridine synthase activity
CWR44_RS10400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWR44_RS10405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWR44_RS10415	COG4974	Belongs to the 'phage' integrase family
CWR44_RS10420	COG0735	belongs to the Fur family
CWR44_RS10425	COG0494	nUDIX hydrolase
CWR44_RS10430	COG0667	Aldo Keto reductase
CWR44_RS10440	COG0300	oxidoreductase activity
CWR44_RS10445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWR44_RS10450	COG1234	tRNA 3'-trailer cleavage
CWR44_RS10455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWR44_RS10465	COG0366	Alpha amylase catalytic
CWR44_RS10470	COG1609	Transcriptional regulator
CWR44_RS10480	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR44_RS10490	COG4129	membrane
CWR44_RS10500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR44_RS10505	COG0022	dehydrogenase e1 component
CWR44_RS10510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWR44_RS10515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR44_RS10520	COG0497	DNA recombination
CWR44_RS10525	COG1438	arginine binding
CWR44_RS10535	COG1722	exodeoxyribonuclease VII activity
CWR44_RS10540	COG1570	exodeoxyribonuclease VII activity
CWR44_RS10545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR44_RS10550	COG1302	Protein conserved in bacteria
CWR44_RS10555	COG0439	Biotin carboxylase
CWR44_RS10560	COG0511	ligase activity, forming carbon-carbon bonds
CWR44_RS10565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWR44_RS10570	COG0006	proline dipeptidase activity
CWR44_RS10585	COG0095	Lipoate-protein ligase
CWR44_RS10590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWR44_RS10595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWR44_RS10600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWR44_RS10605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWR44_RS10610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWR44_RS10635	COG4537	Required for transformation and DNA binding
CWR44_RS10640	COG1459	type II secretion system
CWR44_RS10645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWR44_RS10650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR44_RS10655	COG0011	TIGRFAM Protein of
CWR44_RS10660	COG1940	carbohydrate kinase activity
CWR44_RS10665	COG4483	Protein conserved in bacteria
CWR44_RS10675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWR44_RS10680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWR44_RS10685	COG0768	penicillin binding
CWR44_RS10690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWR44_RS10700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWR44_RS10705	COG1121	(ABC) transporter
CWR44_RS10710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CWR44_RS10715	COG0513	Belongs to the DEAD box helicase family
CWR44_RS10720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWR44_RS10725	COG2384	SAM-dependent methyltransferase
CWR44_RS10730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWR44_RS10740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWR44_RS10745	COG0517	IMP dehydrogenase activity
CWR44_RS10750	COG0423	glycine-tRNA ligase activity
CWR44_RS10755	COG1381	Involved in DNA repair and RecF pathway recombination
CWR44_RS10760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWR44_RS10770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWR44_RS10775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWR44_RS10780	COG1702	phosphate starvation-inducible protein PhoH
CWR44_RS10790	COG4864	UPF0365 protein
CWR44_RS10795	COG1030	water channel activity
CWR44_RS10805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR44_RS10810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWR44_RS10815	COG2264	protein methyltransferase activity
CWR44_RS10820	COG0484	heat shock protein binding
CWR44_RS10825	COG0443	Heat shock 70 kDa protein
CWR44_RS10830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWR44_RS10835	COG1420	regulation of RNA biosynthetic process
CWR44_RS10840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWR44_RS10845	COG0481	GTPase activity
CWR44_RS10850	COG0268	Binds directly to 16S ribosomal RNA
CWR44_RS10855	COG1466	dna polymerase III delta subunit
CWR44_RS10860	COG0658	competence protein
CWR44_RS10860	COG2333	competence protein COMEC
CWR44_RS10865	COG2131	deaminase
CWR44_RS10870	COG1596	polysaccharide export
CWR44_RS10870	COG1555	photosystem II stabilization
CWR44_RS10875	COG2226	methyltransferase
CWR44_RS10880	COG0799	negative regulation of ribosome biogenesis
CWR44_RS10885	COG1713	HD superfamily hydrolase involved in NAD metabolism
CWR44_RS10890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWR44_RS10895	COG1534	Rna-binding protein
CWR44_RS10900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWR44_RS10905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWR44_RS10910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CWR44_RS10915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWR44_RS10920	COG1914	H( )-stimulated, divalent metal cation uptake system
CWR44_RS10925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CWR44_RS10930	COG0439	Biotin carboxylase
CWR44_RS10935	COG0511	ligase activity, forming carbon-carbon bonds
CWR44_RS10940	COG1984	allophanate hydrolase subunit 2
CWR44_RS10945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWR44_RS10950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWR44_RS10955	COG0572	uridine kinase
CWR44_RS10960	COG0826	peptidase U32
CWR44_RS10965	COG0826	peptidase U32
CWR44_RS10975	COG3906	Belongs to the UPF0473 family
CWR44_RS10980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWR44_RS10985	COG4472	Bacterial protein of unknown function (DUF965)
CWR44_RS10990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWR44_RS10995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWR44_RS11005	COG0482	sulfurtransferase activity
CWR44_RS11010	COG1104	cysteine desulfurase activity
CWR44_RS11025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWR44_RS11030	COG1959	2 iron, 2 sulfur cluster binding
CWR44_RS11035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWR44_RS11040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWR44_RS11050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWR44_RS11055	COG0124	histidyl-tRNA synthetase
CWR44_RS11060	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR44_RS11065	COG1490	D-aminoacyl-tRNA deacylase activity
CWR44_RS11070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWR44_RS11075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWR44_RS11080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWR44_RS11080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWR44_RS11085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWR44_RS11085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWR44_RS11090	COG1862	Preprotein translocase
CWR44_RS11095	COG0343	queuine tRNA-ribosyltransferase activity
CWR44_RS11100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWR44_RS11105	COG2255	four-way junction helicase activity
CWR44_RS11110	COG0632	four-way junction helicase activity
CWR44_RS11115	COG4492	Belongs to the UPF0735 family
CWR44_RS11120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWR44_RS11125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWR44_RS11130	COG2868	ribosomal protein
CWR44_RS11135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWR44_RS11145	COG1792	Involved in formation and maintenance of cell shape
CWR44_RS11170	COG2003	Belongs to the UPF0758 family
CWR44_RS11180	COG0285	dihydrofolate synthase activity
CWR44_RS11185	COG0525	valine-tRNA ligase activity
CWR44_RS11190	COG2818	Glycosylase
CWR44_RS11200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWR44_RS11215	COG0181	hydroxymethylbilane synthase activity
CWR44_RS11220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWR44_RS11225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWR44_RS11230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWR44_RS11240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWR44_RS11245	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWR44_RS11255	COG4112	unkown
CWR44_RS11260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWR44_RS11265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWR44_RS11270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWR44_RS11275	COG0833	amino acid
CWR44_RS11280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWR44_RS11285	COG1484	DNA-dependent DNA replication
CWR44_RS11295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWR44_RS11300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWR44_RS11305	COG0237	dephospho-CoA kinase activity
CWR44_RS11315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR44_RS11315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CWR44_RS11320	COG5002	protein histidine kinase activity
CWR44_RS11325	COG0745	RESPONSE REGULATOR receiver
CWR44_RS11330	COG0538	isocitrate dehydrogenase activity
CWR44_RS11335	COG0372	Belongs to the citrate synthase family
CWR44_RS11340	COG1113	amino acid transport
CWR44_RS11350	COG0469	pyruvate kinase activity
CWR44_RS11355	COG0205	6-phosphofructokinase activity
CWR44_RS11360	COG0825	malonyl-CoA metabolic process
CWR44_RS11365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWR44_RS11370	COG0281	malic enzyme
CWR44_RS11375	COG0587	DNA-directed DNA polymerase activity
CWR44_RS11380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWR44_RS11385	COG4109	DRTGG domain
CWR44_RS11395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CWR44_RS11400	COG0006	proline dipeptidase activity
CWR44_RS11405	COG0686	Belongs to the AlaDH PNT family
CWR44_RS11410	COG0589	response to stress
CWR44_RS11420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWR44_RS11425	COG0827	DNA restriction-modification system
CWR44_RS11430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWR44_RS11435	COG0730	response to heat
CWR44_RS11440	COG0301	tRNA thio-modification
CWR44_RS11445	COG1104	cysteine desulfurase activity
CWR44_RS11455	COG1956	GAF domain-containing protein
CWR44_RS11465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWR44_RS11470	COG0584	glycerophosphoryl diester phosphodiesterase
CWR44_RS11475	COG1764	response to oxidative stress
CWR44_RS11485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWR44_RS11495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWR44_RS11495	COG1263	PTS System
CWR44_RS11500	COG0204	Acyl-transferase
CWR44_RS11505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWR44_RS11510	COG0477	Major facilitator Superfamily
CWR44_RS11520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CWR44_RS11530	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CWR44_RS11535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR44_RS11540	COG0454	-acetyltransferase
CWR44_RS11550	COG1609	Transcriptional regulator
CWR44_RS11555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CWR44_RS11555	COG1605	Chorismate mutase
CWR44_RS11565	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CWR44_RS11570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWR44_RS11575	COG1674	ftsk spoiiie
CWR44_RS11580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR44_RS11585	COG4848	Belongs to the UPF0354 family
CWR44_RS11590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR44_RS11595	COG1363	Peptidase, m42
CWR44_RS11605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR44_RS11610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWR44_RS11615	COG0510	thiamine kinase activity
CWR44_RS11625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWR44_RS11645	COG1187	pseudouridine synthase activity
CWR44_RS11650	COG2244	polysaccharide biosynthetic process
CWR44_RS11655	COG2081	HI0933 family
CWR44_RS11660	COG1196	nuclear chromosome segregation
CWR44_RS11660	COG1511	domain protein
CWR44_RS11660	COG4372	Transposase
CWR44_RS11675	COG0495	leucyl-tRNA aminoacylation
CWR44_RS11680	COG2814	Major facilitator Superfamily
CWR44_RS11685	COG1242	4 iron, 4 sulfur cluster binding
CWR44_RS11690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CWR44_RS11710	COG2267	carboxylic ester hydrolase activity
CWR44_RS11715	COG0506	proline dehydrogenase activity
CWR44_RS11720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWR44_RS11725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWR44_RS11725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWR44_RS11730	COG0307	riboflavin synthase, alpha
CWR44_RS11735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWR44_RS11735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWR44_RS11750	COG4193	domain, Protein
CWR44_RS11750	COG3266	domain, Protein
CWR44_RS11750	COG5632	N-Acetylmuramoyl-L-alanine amidase
CWR44_RS11775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWR44_RS11785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWR44_RS11790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWR44_RS11795	COG0656	L-ascorbic acid biosynthetic process
CWR44_RS11805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWR44_RS11810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CWR44_RS11815	COG1506	peptidase
CWR44_RS11820	COG0494	nUDIX hydrolase
CWR44_RS11825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWR44_RS11835	COG0318	PFAM AMP-dependent synthetase and ligase
CWR44_RS11885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWR44_RS11890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWR44_RS11895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWR44_RS11905	COG4473	ABC transporter
CWR44_RS11910	COG1131	(ABC) transporter
CWR44_RS11915	COG0537	adenosine 5'-monophosphoramidase activity
CWR44_RS11930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR44_RS11935	COG3481	metal-dependent phosphohydrolase, HD sub domain
CWR44_RS11940	COG4717	serine-type aminopeptidase activity
CWR44_RS11950	COG3679	Belongs to the UPF0342 family
CWR44_RS11955	COG4399	Belongs to the UPF0754 family
CWR44_RS11965	COG2197	response regulator
CWR44_RS11970	COG2203	Gaf domain
CWR44_RS11970	COG4585	Histidine kinase
CWR44_RS11975	COG0564	pseudouridine synthase activity
CWR44_RS11980	COG0114	fumarate hydratase activity
CWR44_RS11995	COG0363	glucosamine-6-phosphate deaminase activity
CWR44_RS12005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWR44_RS12010	COG1126	abc transporter atp-binding protein
CWR44_RS12015	COG0765	amino acid transport
CWR44_RS12175	COG0735	belongs to the Fur family
CWR44_RS12180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWR44_RS12185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWR44_RS12190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWR44_RS12195	COG4129	membrane
CWR44_RS12210	COG3557	Belongs to the UPF0374 family
CWR44_RS12215	COG1194	a g-specific adenine glycosylase
CWR44_RS12220	COG1988	membrane-bound metal-dependent
CWR44_RS12230	COG1134	teichoic acid transport
CWR44_RS12230	COG1388	LysM domain
CWR44_RS12240	COG2137	regulation of response to DNA damage stimulus
CWR44_RS12245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWR44_RS12250	COG0693	protein deglycase activity
CWR44_RS12260	COG0535	radical SAM domain protein
CWR44_RS12270	COG1607	acyl-coa hydrolase
CWR44_RS12275	COG2309	aminopeptidase activity
CWR44_RS12280	COG4840	Belongs to the UPF0435 family
CWR44_RS12285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWR44_RS12295	COG1295	ribonuclease BN
CWR44_RS12300	COG2197	response regulator
CWR44_RS12305	COG4585	Histidine kinase
CWR44_RS12325	COG4221	oxidoreductase activity
CWR44_RS12330	COG0024	Methionine aminopeptidase
CWR44_RS12335	COG4129	membrane
CWR44_RS12350	COG1528	Iron-storage protein
CWR44_RS12360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWR44_RS12370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWR44_RS12375	COG1597	lipid kinase activity
CWR44_RS12380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWR44_RS12385	COG0154	amidase activity
CWR44_RS12390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWR44_RS12395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWR44_RS12400	COG4851	CamS sex pheromone cAM373 precursor
CWR44_RS12405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWR44_RS12410	COG0210	DNA helicase
CWR44_RS12415	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CWR44_RS12420	COG4496	protein, YerC YecD
CWR44_RS12425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWR44_RS12435	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CWR44_RS12440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWR44_RS12445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWR44_RS12455	COG0077	Prephenate dehydratase
CWR44_RS12455	COG1605	Chorismate mutase
CWR44_RS12470	COG1335	isochorismatase
CWR44_RS12475	COG1227	inorganic diphosphatase activity
CWR44_RS12480	COG1012	belongs to the aldehyde dehydrogenase family
CWR44_RS12485	COG2706	6-phosphogluconolactonase activity
CWR44_RS12530	COG1131	(ABC) transporter
CWR44_RS12545	COG1725	Transcriptional regulator
CWR44_RS12605	COG0582	viral genome integration into host DNA
CWR44_RS12610	COG0459	protein refolding
CWR44_RS12615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWR44_RS12640	COG4512	PFAM Accessory gene regulator B
CWR44_RS12655	COG3279	Response regulator of the LytR AlgR family
CWR44_RS12660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR44_RS12665	COG1621	beta-fructofuranosidase activity
CWR44_RS12670	COG1609	Transcriptional regulator
CWR44_RS12675	COG0004	ammonium transporteR
CWR44_RS12680	COG0425	Belongs to the sulfur carrier protein TusA family
CWR44_RS12685	COG2391	methyltransferase activity
CWR44_RS12690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CWR44_RS12695	COG0488	(ABC) transporter
CWR44_RS12700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWR44_RS12705	COG0456	acetyltransferase
CWR44_RS12710	COG1214	PFAM Peptidase M22, glycoprotease
CWR44_RS12715	COG0802	atpase or kinase
CWR44_RS12720	COG0129	dihydroxy-acid dehydratase activity
CWR44_RS12725	COG0028	Belongs to the TPP enzyme family
CWR44_RS12730	COG0440	acetolactate synthase activity
CWR44_RS12735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWR44_RS12740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR44_RS12745	COG0473	3-isopropylmalate dehydrogenase activity
CWR44_RS12750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWR44_RS12755	COG0066	3-isopropylmalate dehydratase activity
CWR44_RS12760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR44_RS12800	COG2183	response to ionizing radiation
CWR44_RS12805	COG1191	sigma factor activity
CWR44_RS12820	COG2208	phosphoserine phosphatase activity
CWR44_RS12825	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWR44_RS12835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWR44_RS12840	COG0736	holo-[acyl-carrier-protein] synthase activity
CWR44_RS12845	COG3402	PFAM membrane-flanked domain
CWR44_RS12850	COG3428	Bacterial PH domain
CWR44_RS12860	COG0513	Belongs to the DEAD box helicase family
CWR44_RS12865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWR44_RS12870	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR44_RS12875	COG0772	Belongs to the SEDS family
CWR44_RS12895	COG1937	Protein conserved in bacteria
CWR44_RS12905	COG1418	mRNA catabolic process
CWR44_RS12915	COG0706	membrane insertase activity
CWR44_RS12940	COG1388	LysM domain
CWR44_RS12955	COG1368	sulfuric ester hydrolase activity
CWR44_RS12985	COG0512	Glutamine amidotransferase of anthranilate synthase
CWR44_RS12985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWR44_RS12995	COG0720	synthase
CWR44_RS13020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWR44_RS13125	COG3173	Aminoglycoside phosphotransferase
CWR44_RS13155	COG1230	cation diffusion facilitator family transporter
CWR44_RS13165	COG1937	Protein conserved in bacteria
CWR44_RS13170	COG2217	Heavy metal translocating P-type atpase