locus-tag	class	description
ShL2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ShL2_RS00010	COG0592	DNA-directed DNA polymerase activity
ShL2_RS00015	COG2501	S4 domain
ShL2_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ShL2_RS00025	COG0187	DNA topoisomerase II activity
ShL2_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ShL2_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ShL2_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ShL2_RS00045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ShL2_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ShL2_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ShL2_RS00070	COG0359	binds to the 23S rRNA
ShL2_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
ShL2_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ShL2_RS00100	COG0745	RESPONSE REGULATOR receiver
ShL2_RS00105	COG5002	protein histidine kinase activity
ShL2_RS00110	COG4863	YycH protein
ShL2_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ShL2_RS00125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ShL2_RS00135	COG0640	Transcriptional regulator
ShL2_RS00140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ShL2_RS00165	COG2030	dehydratase
ShL2_RS00170	COG0584	glycerophosphoryl diester phosphodiesterase
ShL2_RS00185	COG2217	Heavy metal translocating P-type atpase
ShL2_RS00190	COG1388	LysM domain
ShL2_RS00215	COG0789	Transcriptional regulator
ShL2_RS00225	COG0702	epimerase
ShL2_RS00230	COG2130	NADP-dependent
ShL2_RS00245	COG0640	Transcriptional regulator
ShL2_RS00250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ShL2_RS00255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ShL2_RS00265	COG0668	transmembrane transport
ShL2_RS00285	COG0803	Belongs to the bacterial solute-binding protein 9 family
ShL2_RS00315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ShL2_RS00340	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ShL2_RS00350	COG0803	Belongs to the bacterial solute-binding protein 9 family
ShL2_RS00355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ShL2_RS00360	COG1121	(ABC) transporter
ShL2_RS00365	COG0523	cobalamin synthesis protein
ShL2_RS00370	COG1114	Component of the transport system for branched-chain amino acids
ShL2_RS00380	COG0747	negative chemotaxis
ShL2_RS00390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ShL2_RS00395	COG4172	Belongs to the ABC transporter superfamily
ShL2_RS00425	COG0789	Transcriptional regulator
ShL2_RS00435	COG1253	flavin adenine dinucleotide binding
ShL2_RS00440	COG1959	2 iron, 2 sulfur cluster binding
ShL2_RS00445	COG2910	NAD(P)H-binding
ShL2_RS00465	COG1113	amino acid transport
ShL2_RS00470	COG0778	Nitroreductase
ShL2_RS00515	COG1609	Transcriptional regulator
ShL2_RS00520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ShL2_RS00525	COG1869	D-ribose catabolic process
ShL2_RS00530	COG1129	ABC transporter
ShL2_RS00535	COG1172	Belongs to the binding-protein-dependent transport system permease family
ShL2_RS00540	COG1879	ABC-type sugar transport system periplasmic component
ShL2_RS00550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ShL2_RS00555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ShL2_RS00560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ShL2_RS00570	COG1876	peptidase activity
ShL2_RS00575	COG1737	Transcriptional regulator
ShL2_RS00580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ShL2_RS00585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ShL2_RS00590	COG1447	Phosphotransferase system cellobiose-specific component IIA
ShL2_RS00605	COG2971	BadF BadG BcrA BcrD
ShL2_RS00615	COG3152	Membrane
ShL2_RS00625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ShL2_RS00635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ShL2_RS00640	COG2249	NAD(P)H dehydrogenase (quinone) activity
ShL2_RS00645	COG1288	antiporter activity
ShL2_RS00660	COG2318	DinB family
ShL2_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
ShL2_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS00710	COG1063	alcohol dehydrogenase
ShL2_RS00715	COG1846	Transcriptional regulator
ShL2_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ShL2_RS00735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ShL2_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ShL2_RS00750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ShL2_RS00755	COG0022	dehydrogenase e1 component
ShL2_RS00760	COG0508	dehydrogenase complex catalyzes the overall conversion of
ShL2_RS00770	COG1695	Transcriptional regulator
ShL2_RS00785	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ShL2_RS00790	COG2962	Rard protein
ShL2_RS00855	COG0789	Transcriptional regulator
ShL2_RS00895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ShL2_RS00900	COG0549	Belongs to the carbamate kinase family
ShL2_RS00910	COG3093	addiction module antidote protein HigA
ShL2_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ShL2_RS00950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ShL2_RS00960	COG0471	metal ion transport
ShL2_RS00965	COG5505	Protein of unknown function (DUF819)
ShL2_RS00970	COG4336	lyase activity
ShL2_RS00980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ShL2_RS00990	COG0363	glucosamine-6-phosphate deaminase activity
ShL2_RS00995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ShL2_RS01010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ShL2_RS01015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ShL2_RS01040	COG1124	(ABC) transporter
ShL2_RS01045	COG0444	Belongs to the ABC transporter superfamily
ShL2_RS01060	COG0747	negative chemotaxis
ShL2_RS01065	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ShL2_RS01085	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ShL2_RS01095	COG1054	Belongs to the UPF0176 family
ShL2_RS01100	COG3386	PFAM SMP-30 Gluconolaconase
ShL2_RS01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ShL2_RS01125	COG4716	Myosin-crossreactive antigen
ShL2_RS01145	COG1131	(ABC) transporter
ShL2_RS01155	COG1476	TRANSCRIPTIONal
ShL2_RS01160	COG1959	2 iron, 2 sulfur cluster binding
ShL2_RS01165	COG0697	spore germination
ShL2_RS01170	COG2814	Major facilitator Superfamily
ShL2_RS01180	COG0737	Belongs to the 5'-nucleotidase family
ShL2_RS01190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ShL2_RS01195	COG3639	organic phosphonate transmembrane transporter activity
ShL2_RS01220	COG3391	amine dehydrogenase activity
ShL2_RS01240	COG0201	protein transport
ShL2_RS01250	COG1073	alpha beta
ShL2_RS01255	COG0653	protein targeting
ShL2_RS01270	COG0642	Histidine kinase
ShL2_RS01275	COG0745	RESPONSE REGULATOR receiver
ShL2_RS01295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ShL2_RS01315	COG2814	Major facilitator Superfamily
ShL2_RS01325	COG2113	Glycine betaine
ShL2_RS01330	COG2409	Drug exporters of the RND superfamily
ShL2_RS01335	COG0583	DNA-binding transcription factor activity
ShL2_RS01340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ShL2_RS01350	COG1288	antiporter activity
ShL2_RS01355	COG2190	(PTS) system
ShL2_RS01355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS01355	COG1263	PTS System
ShL2_RS01360	COG3942	CHAP domain
ShL2_RS01360	COG1705	Flagellar rod assembly protein muramidase FlgJ
ShL2_RS01360	COG1705	Flagellar rod assembly protein muramidase FlgJ
ShL2_RS01360	COG3942	CHAP domain
ShL2_RS01395	COG2235	arginine
ShL2_RS01405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ShL2_RS01430	COG5658	integral membrane protein
ShL2_RS01440	COG3961	Belongs to the TPP enzyme family
ShL2_RS01450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ShL2_RS01485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ShL2_RS01510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ShL2_RS01520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ShL2_RS01525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ShL2_RS01530	COG1316	TRANSCRIPTIONal
ShL2_RS01535	COG1785	Belongs to the alkaline phosphatase family
ShL2_RS01545	COG2205	protein histidine kinase activity
ShL2_RS01550	COG1136	(ABC) transporter
ShL2_RS01585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ShL2_RS01605	COG0730	response to heat
ShL2_RS01610	COG2046	Belongs to the sulfate adenylyltransferase family
ShL2_RS01615	COG0529	Catalyzes the synthesis of activated sulfate
ShL2_RS01620	COG2851	Citrate transporter
ShL2_RS01635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ShL2_RS01640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ShL2_RS01645	COG1510	regulation of RNA biosynthetic process
ShL2_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS01655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ShL2_RS01665	COG1473	amidohydrolase
ShL2_RS01675	COG1473	amidohydrolase
ShL2_RS01690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ShL2_RS01700	COG0583	DNA-binding transcription factor activity
ShL2_RS01710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ShL2_RS01710	COG0574	Belongs to the PEP-utilizing enzyme family
ShL2_RS01715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ShL2_RS01720	COG0579	oxidoreductase
ShL2_RS01730	COG2723	6-phospho-beta-galactosidase activity
ShL2_RS01750	COG3588	fructose-bisphosphate aldolase
ShL2_RS01780	COG1464	Belongs to the NlpA lipoprotein family
ShL2_RS01790	COG0531	amino acid
ShL2_RS01795	COG0028	Belongs to the TPP enzyme family
ShL2_RS01800	COG3527	Alpha-acetolactate decarboxylase
ShL2_RS01835	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ShL2_RS01845	COG0167	dihydroorotate dehydrogenase activity
ShL2_RS01850	COG3001	Fructosamine kinase
ShL2_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ShL2_RS01910	COG0741	lytic transglycosylase activity
ShL2_RS01920	COG1233	COG1233 Phytoene dehydrogenase and related
ShL2_RS01925	COG0463	Glycosyl transferase, family 2
ShL2_RS01930	COG1562	ergosterol biosynthetic process
ShL2_RS01935	COG1233	COG1233 Phytoene dehydrogenase and related
ShL2_RS01940	COG0436	Aminotransferase
ShL2_RS01950	COG2608	mercury ion transmembrane transporter activity
ShL2_RS01955	COG2217	Heavy metal translocating P-type atpase
ShL2_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
ShL2_RS01970	COG0110	maltose O-acetyltransferase activity
ShL2_RS01975	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS01995	COG0598	Magnesium transport protein CorA
ShL2_RS02005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ShL2_RS02010	COG3425	synthase
ShL2_RS02025	COG3942	CHAP domain
ShL2_RS02025	COG1388	LysM domain
ShL2_RS02035	COG0583	DNA-binding transcription factor activity
ShL2_RS02040	COG1380	Effector of murein hydrolase LrgA
ShL2_RS02045	COG1346	cytolysis
ShL2_RS02050	COG0028	Belongs to the TPP enzyme family
ShL2_RS02060	COG1263	PTS System
ShL2_RS02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS02060	COG2190	(PTS) system
ShL2_RS02080	COG0039	L-malate dehydrogenase activity
ShL2_RS02090	COG0697	spore germination
ShL2_RS02100	COG1917	Cupin 2, conserved barrel domain protein
ShL2_RS02100	COG2207	Transcriptional regulator
ShL2_RS02110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ShL2_RS02130	COG1070	Carbohydrate kinase
ShL2_RS02140	COG1760	l-serine dehydratase
ShL2_RS02145	COG1760	l-serine dehydratase
ShL2_RS02160	COG3764	Sortase (surface protein transpeptidase)
ShL2_RS02190	COG2514	catechol 2,3-dioxygenase activity
ShL2_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS02210	COG1846	Transcriptional regulator
ShL2_RS02215	COG0346	lactoylglutathione lyase activity
ShL2_RS02220	COG0346	lactoylglutathione lyase activity
ShL2_RS02225	COG0400	carboxylic ester hydrolase activity
ShL2_RS02230	COG3949	Membrane
ShL2_RS02240	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ShL2_RS02245	COG0586	Pfam SNARE associated Golgi protein
ShL2_RS02255	COG2022	thiamine diphosphate biosynthetic process
ShL2_RS02260	COG2104	thiamine diphosphate biosynthetic process
ShL2_RS02260	COG2022	thiamine diphosphate biosynthetic process
ShL2_RS02265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ShL2_RS02275	COG2271	Major facilitator Superfamily
ShL2_RS02290	COG4876	unkown
ShL2_RS02295	COG2357	RelA SpoT domain protein
ShL2_RS02310	COG1802	Transcriptional regulator
ShL2_RS02315	COG1070	Carbohydrate kinase
ShL2_RS02320	COG2610	gluconate transmembrane transporter activity
ShL2_RS02330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ShL2_RS02375	COG4221	oxidoreductase activity
ShL2_RS02380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ShL2_RS02385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ShL2_RS02395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ShL2_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
ShL2_RS02405	COG1363	Peptidase, m42
ShL2_RS02420	COG0069	glutamate synthase activity
ShL2_RS02435	COG4619	ABC transporter
ShL2_RS02440	COG0390	transport system, permease component
ShL2_RS02445	COG2205	protein histidine kinase activity
ShL2_RS02450	COG0745	RESPONSE REGULATOR receiver
ShL2_RS02460	COG2814	Major facilitator Superfamily
ShL2_RS02465	COG2272	Belongs to the type-B carboxylesterase lipase family
ShL2_RS02470	COG0531	amino acid
ShL2_RS02475	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ShL2_RS02480	COG1063	alcohol dehydrogenase
ShL2_RS02500	COG1174	glycine betaine transport
ShL2_RS02505	COG1346	cytolysis
ShL2_RS02510	COG1380	Effector of murein hydrolase LrgA
ShL2_RS02515	COG3279	Response regulator of the LytR AlgR family
ShL2_RS02530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ShL2_RS02540	COG3477	response to acidic pH
ShL2_RS02550	COG0706	membrane insertase activity
ShL2_RS02560	COG0531	amino acid
ShL2_RS02570	COG1113	amino acid transport
ShL2_RS02590	COG2226	methyltransferase
ShL2_RS02595	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ShL2_RS02600	COG2814	Major facilitator Superfamily
ShL2_RS02610	COG1929	Belongs to the glycerate kinase type-1 family
ShL2_RS02625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ShL2_RS02630	COG0741	lytic transglycosylase activity
ShL2_RS02635	COG0588	phosphoglycerate mutase activity
ShL2_RS02640	COG2814	Major facilitator Superfamily
ShL2_RS02650	COG0765	amino acid transport
ShL2_RS02655	COG1126	abc transporter atp-binding protein
ShL2_RS02680	COG2353	YceI-like domain
ShL2_RS02705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ShL2_RS02710	COG2146	nitrite reductase [NAD(P)H] activity
ShL2_RS02720	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ShL2_RS02725	COG1140	nitrate reductase beta subunit
ShL2_RS02730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ShL2_RS02735	COG2181	nitrate reductase activity
ShL2_RS02745	COG4585	Histidine kinase
ShL2_RS02750	COG2197	response regulator
ShL2_RS02755	COG2223	nitrite transmembrane transporter activity
ShL2_RS02765	COG1846	Transcriptional regulator
ShL2_RS02790	COG3871	stress protein (general stress protein 26)
ShL2_RS02805	COG1263	PTS System
ShL2_RS02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS02830	COG0534	Mate efflux family protein
ShL2_RS02850	COG0492	ferredoxin-NADP+ reductase activity
ShL2_RS02860	COG0604	alcohol dehydrogenase
ShL2_RS02865	COG2822	iron ion transport
ShL2_RS02870	COG2837	iron assimilation
ShL2_RS02875	COG0672	)-iron permease
ShL2_RS02880	COG0805	protein transport
ShL2_RS02885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ShL2_RS02905	COG0438	transferase activity, transferring glycosyl groups
ShL2_RS02910	COG0579	oxidoreductase
ShL2_RS02925	COG3850	Histidine kinase
ShL2_RS02925	COG5002	protein histidine kinase activity
ShL2_RS02930	COG0745	RESPONSE REGULATOR receiver
ShL2_RS02940	COG1136	(ABC) transporter
ShL2_RS02960	COG2814	Major facilitator Superfamily
ShL2_RS02970	COG1566	PFAM secretion protein HlyD family protein
ShL2_RS03000	COG0598	Magnesium transport protein CorA
ShL2_RS03005	COG1304	FMN binding
ShL2_RS03010	COG0786	glutamate:sodium symporter activity
ShL2_RS03015	COG2094	Belongs to the DNA glycosylase MPG family
ShL2_RS03030	COG1742	UPF0060 membrane protein
ShL2_RS03040	COG2258	MOSC domain
ShL2_RS03045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ShL2_RS03055	COG1266	CAAX protease self-immunity
ShL2_RS03060	COG0010	Belongs to the arginase family
ShL2_RS03070	COG1473	amidohydrolase
ShL2_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
ShL2_RS03080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ShL2_RS03095	COG1737	Transcriptional regulator
ShL2_RS03100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS03100	COG1263	PTS System
ShL2_RS03110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ShL2_RS03130	COG1113	amino acid transport
ShL2_RS03145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS03145	COG1263	PTS System
ShL2_RS03150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ShL2_RS03165	COG2378	regulation of single-species biofilm formation
ShL2_RS03175	COG1316	TRANSCRIPTIONal
ShL2_RS03180	COG3383	formate dehydrogenase (NAD+) activity
ShL2_RS03185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ShL2_RS03205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ShL2_RS03210	COG2076	Multidrug Resistance protein
ShL2_RS03215	COG2076	Multidrug Resistance protein
ShL2_RS03220	COG3942	CHAP domain
ShL2_RS03235	COG1757	Na H antiporter
ShL2_RS03245	COG3942	CHAP domain
ShL2_RS03270	COG1960	acyl-CoA dehydrogenase activity
ShL2_RS03275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ShL2_RS03280	COG1957	nucleoside hydrolase
ShL2_RS03285	COG1268	BioY protein
ShL2_RS03295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ShL2_RS03300	COG0725	ABC transporter, periplasmic molybdate-binding protein
ShL2_RS03305	COG4149	molybdate abc transporter
ShL2_RS03315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ShL2_RS03325	COG0315	cyclic pyranopterin monophosphate synthase activity
ShL2_RS03350	COG0746	molybdenum cofactor guanylyltransferase activity
ShL2_RS03355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ShL2_RS03380	COG2348	transferase activity, transferring amino-acyl groups
ShL2_RS03385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ShL2_RS03405	COG4975	Glucose uptake
ShL2_RS03415	COG0551	DNA topoisomerase type I activity
ShL2_RS03415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ShL2_RS03420	COG2252	PERMEase
ShL2_RS03430	COG0051	transcription antitermination factor activity, RNA binding
ShL2_RS03435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ShL2_RS03440	COG0088	Forms part of the polypeptide exit tunnel
ShL2_RS03445	COG0089	rRNA binding
ShL2_RS03450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ShL2_RS03455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ShL2_RS03460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ShL2_RS03465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ShL2_RS03470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ShL2_RS03475	COG0255	Belongs to the universal ribosomal protein uL29 family
ShL2_RS03480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ShL2_RS03485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ShL2_RS03490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ShL2_RS03495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ShL2_RS03505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ShL2_RS03510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ShL2_RS03515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ShL2_RS03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ShL2_RS03525	COG1841	ribosomal large subunit assembly
ShL2_RS03530	COG0200	Binds to the 23S rRNA
ShL2_RS03535	COG0201	protein transport
ShL2_RS03540	COG0563	adenylate kinase activity
ShL2_RS03545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ShL2_RS03550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ShL2_RS03555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ShL2_RS03565	COG0202	RNA polymerase activity
ShL2_RS03570	COG0203	ribosomal protein L17
ShL2_RS03580	COG1122	ATPase activity
ShL2_RS03590	COG0101	tRNA pseudouridine synthase activity
ShL2_RS03595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ShL2_RS03600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ShL2_RS03605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ShL2_RS03610	COG1349	DNA-binding transcription factor activity
ShL2_RS03620	COG0698	ribose 5-phosphate isomerase
ShL2_RS03625	COG0698	ribose 5-phosphate isomerase
ShL2_RS03630	COG1105	Belongs to the carbohydrate kinase PfkB family
ShL2_RS03635	COG3684	Belongs to the aldolase LacD family
ShL2_RS03640	COG1447	Phosphotransferase system cellobiose-specific component IIA
ShL2_RS03645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ShL2_RS03645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ShL2_RS03650	COG2723	6-phospho-beta-galactosidase activity
ShL2_RS03660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ShL2_RS03665	COG0604	alcohol dehydrogenase
ShL2_RS03670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ShL2_RS03685	COG1302	Protein conserved in bacteria
ShL2_RS03700	COG4264	IucA IucC family
ShL2_RS03705	COG2814	Major facilitator Superfamily
ShL2_RS03715	COG3457	Alanine racemase
ShL2_RS03720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ShL2_RS03725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS03730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS03735	COG3314	Sporulation integral membrane protein YlbJ
ShL2_RS03740	COG2329	Antibiotic biosynthesis monooxygenase
ShL2_RS03750	COG1988	membrane-bound metal-dependent
ShL2_RS03755	COG4284	Utp--glucose-1-phosphate uridylyltransferase
ShL2_RS03760	COG1272	protein, Hemolysin III
ShL2_RS03775	COG2814	Major facilitator Superfamily
ShL2_RS03780	COG0489	protein tyrosine kinase activity
ShL2_RS03835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ShL2_RS03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ShL2_RS03855	COG1119	ATPase activity
ShL2_RS03860	COG0561	phosphatase activity
ShL2_RS03885	COG0640	Transcriptional regulator
ShL2_RS03890	COG0702	epimerase
ShL2_RS03895	COG1482	cell wall glycoprotein biosynthetic process
ShL2_RS03915	COG0783	Belongs to the Dps family
ShL2_RS03920	COG0813	purine-nucleoside phosphorylase activity
ShL2_RS03925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ShL2_RS03935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ShL2_RS03945	COG1854	S-ribosylhomocysteine lyase activity
ShL2_RS03965	COG5146	pantothenate kinase activity
ShL2_RS03980	COG0504	CTP synthase activity
ShL2_RS03990	COG0191	fructose-bisphosphate aldolase activity
ShL2_RS03995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ShL2_RS04005	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS04010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ShL2_RS04015	COG0254	rRNA binding
ShL2_RS04020	COG1435	thymidine kinase activity
ShL2_RS04025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ShL2_RS04030	COG2890	protein-(glutamine-N5) methyltransferase activity
ShL2_RS04035	COG0009	L-threonylcarbamoyladenylate synthase
ShL2_RS04040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ShL2_RS04045	COG4475	Protein of unknown function (DUF436)
ShL2_RS04050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ShL2_RS04055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ShL2_RS04060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ShL2_RS04070	COG0356	it plays a direct role in the translocation of protons across the membrane
ShL2_RS04075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ShL2_RS04080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ShL2_RS04085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ShL2_RS04090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ShL2_RS04095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ShL2_RS04100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ShL2_RS04105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ShL2_RS04115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ShL2_RS04120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ShL2_RS04130	COG0629	single-stranded DNA binding
ShL2_RS04135	COG1388	LysM domain
ShL2_RS04140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ShL2_RS04150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ShL2_RS04155	COG0352	thiamine-phosphate diphosphorylase activity
ShL2_RS04175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ShL2_RS04180	COG1937	Protein conserved in bacteria
ShL2_RS04195	COG0772	Belongs to the SEDS family
ShL2_RS04200	COG1181	Belongs to the D-alanine--D-alanine ligase family
ShL2_RS04205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ShL2_RS04210	COG0513	Belongs to the DEAD box helicase family
ShL2_RS04220	COG3428	Bacterial PH domain
ShL2_RS04225	COG3402	PFAM membrane-flanked domain
ShL2_RS04230	COG0736	holo-[acyl-carrier-protein] synthase activity
ShL2_RS04235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ShL2_RS04245	COG2337	Toxic component of a toxin-antitoxin (TA) module
ShL2_RS04250	COG2208	phosphoserine phosphatase activity
ShL2_RS04265	COG1191	sigma factor activity
ShL2_RS04270	COG2183	response to ionizing radiation
ShL2_RS04310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ShL2_RS04315	COG0066	3-isopropylmalate dehydratase activity
ShL2_RS04320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ShL2_RS04325	COG0473	3-isopropylmalate dehydrogenase activity
ShL2_RS04330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ShL2_RS04340	COG0440	acetolactate synthase activity
ShL2_RS04345	COG0028	Belongs to the TPP enzyme family
ShL2_RS04350	COG0129	dihydroxy-acid dehydratase activity
ShL2_RS04355	COG0802	atpase or kinase
ShL2_RS04360	COG1214	PFAM Peptidase M22, glycoprotease
ShL2_RS04365	COG0456	acetyltransferase
ShL2_RS04370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ShL2_RS04375	COG0488	(ABC) transporter
ShL2_RS04380	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ShL2_RS04385	COG2391	methyltransferase activity
ShL2_RS04390	COG0425	Belongs to the sulfur carrier protein TusA family
ShL2_RS04400	COG1609	Transcriptional regulator
ShL2_RS04410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ShL2_RS04415	COG3279	Response regulator of the LytR AlgR family
ShL2_RS04430	COG4512	PFAM Accessory gene regulator B
ShL2_RS04455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ShL2_RS04460	COG0459	protein refolding
ShL2_RS04465	COG0582	viral genome integration into host DNA
ShL2_RS04525	COG1725	Transcriptional regulator
ShL2_RS04540	COG1131	(ABC) transporter
ShL2_RS04575	COG2706	6-phosphogluconolactonase activity
ShL2_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS04585	COG1227	inorganic diphosphatase activity
ShL2_RS04590	COG1335	isochorismatase
ShL2_RS04600	COG0077	Prephenate dehydratase
ShL2_RS04600	COG1605	Chorismate mutase
ShL2_RS04610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ShL2_RS04615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ShL2_RS04620	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ShL2_RS04625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ShL2_RS04630	COG4496	protein, YerC YecD
ShL2_RS04635	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ShL2_RS04640	COG0210	DNA helicase
ShL2_RS04645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ShL2_RS04650	COG4851	CamS sex pheromone cAM373 precursor
ShL2_RS04655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ShL2_RS04660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ShL2_RS04665	COG0154	amidase activity
ShL2_RS04670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ShL2_RS04675	COG1597	lipid kinase activity
ShL2_RS04680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ShL2_RS04690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ShL2_RS04700	COG1528	Iron-storage protein
ShL2_RS04725	COG0024	Methionine aminopeptidase
ShL2_RS04730	COG4221	oxidoreductase activity
ShL2_RS04750	COG4585	Histidine kinase
ShL2_RS04755	COG2197	response regulator
ShL2_RS04760	COG1295	ribonuclease BN
ShL2_RS04770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ShL2_RS04775	COG4840	Belongs to the UPF0435 family
ShL2_RS04780	COG2309	aminopeptidase activity
ShL2_RS04785	COG1607	acyl-coa hydrolase
ShL2_RS04805	COG0693	protein deglycase activity
ShL2_RS04810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ShL2_RS04825	COG1134	teichoic acid transport
ShL2_RS04825	COG1388	LysM domain
ShL2_RS04840	COG1988	membrane-bound metal-dependent
ShL2_RS04845	COG1194	a g-specific adenine glycosylase
ShL2_RS04850	COG3557	Belongs to the UPF0374 family
ShL2_RS04865	COG4129	membrane
ShL2_RS04870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ShL2_RS04875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ShL2_RS04880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ShL2_RS04885	COG0735	belongs to the Fur family
ShL2_RS05050	COG0765	amino acid transport
ShL2_RS05055	COG1126	abc transporter atp-binding protein
ShL2_RS05060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ShL2_RS05070	COG0363	glucosamine-6-phosphate deaminase activity
ShL2_RS05080	COG0114	fumarate hydratase activity
ShL2_RS05085	COG0564	pseudouridine synthase activity
ShL2_RS05090	COG2203	Gaf domain
ShL2_RS05090	COG4585	Histidine kinase
ShL2_RS05095	COG2197	response regulator
ShL2_RS05105	COG4399	Belongs to the UPF0754 family
ShL2_RS05110	COG3679	Belongs to the UPF0342 family
ShL2_RS05120	COG4717	serine-type aminopeptidase activity
ShL2_RS05125	COG3481	metal-dependent phosphohydrolase, HD sub domain
ShL2_RS05145	COG0537	adenosine 5'-monophosphoramidase activity
ShL2_RS05150	COG1131	(ABC) transporter
ShL2_RS05155	COG4473	ABC transporter
ShL2_RS05165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ShL2_RS05170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ShL2_RS05175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ShL2_RS05225	COG0318	PFAM AMP-dependent synthetase and ligase
ShL2_RS05235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ShL2_RS05240	COG0494	nUDIX hydrolase
ShL2_RS05245	COG1506	peptidase
ShL2_RS05250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ShL2_RS05255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ShL2_RS05265	COG0656	L-ascorbic acid biosynthetic process
ShL2_RS05285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ShL2_RS05310	COG4193	domain, Protein
ShL2_RS05310	COG5632	N-Acetylmuramoyl-L-alanine amidase
ShL2_RS05310	COG3266	domain, Protein
ShL2_RS05325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ShL2_RS05325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ShL2_RS05330	COG0307	riboflavin synthase, alpha
ShL2_RS05335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ShL2_RS05335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ShL2_RS05340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ShL2_RS05345	COG0506	proline dehydrogenase activity
ShL2_RS05350	COG2267	carboxylic ester hydrolase activity
ShL2_RS05365	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ShL2_RS05375	COG2814	Major facilitator Superfamily
ShL2_RS05380	COG0495	leucyl-tRNA aminoacylation
ShL2_RS05395	COG1196	nuclear chromosome segregation
ShL2_RS05395	COG1511	domain protein
ShL2_RS05395	COG4372	Transposase
ShL2_RS05400	COG2081	HI0933 family
ShL2_RS05405	COG2244	polysaccharide biosynthetic process
ShL2_RS05410	COG1187	pseudouridine synthase activity
ShL2_RS05420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ShL2_RS05430	COG0510	thiamine kinase activity
ShL2_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ShL2_RS05445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ShL2_RS05455	COG1363	Peptidase, m42
ShL2_RS05460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ShL2_RS05465	COG4848	Belongs to the UPF0354 family
ShL2_RS05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ShL2_RS05485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ShL2_RS05490	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ShL2_RS05505	COG1605	Chorismate mutase
ShL2_RS05505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ShL2_RS05510	COG1609	Transcriptional regulator
ShL2_RS05520	COG0454	-acetyltransferase
ShL2_RS05525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ShL2_RS05530	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ShL2_RS05540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ShL2_RS05550	COG0477	Major facilitator Superfamily
ShL2_RS05555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ShL2_RS05560	COG0204	Acyl-transferase
ShL2_RS05565	COG1263	PTS System
ShL2_RS05565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS05575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ShL2_RS05585	COG1764	response to oxidative stress
ShL2_RS05590	COG0584	glycerophosphoryl diester phosphodiesterase
ShL2_RS05595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ShL2_RS05600	COG1956	GAF domain-containing protein
ShL2_RS05615	COG0301	tRNA thio-modification
ShL2_RS05620	COG0730	response to heat
ShL2_RS05625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ShL2_RS05630	COG0827	DNA restriction-modification system
ShL2_RS05640	COG0589	response to stress
ShL2_RS05645	COG0686	Belongs to the AlaDH PNT family
ShL2_RS05650	COG0006	proline dipeptidase activity
ShL2_RS05655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ShL2_RS05665	COG4109	DRTGG domain
ShL2_RS05670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ShL2_RS05675	COG0587	DNA-directed DNA polymerase activity
ShL2_RS05680	COG0281	malic enzyme
ShL2_RS05685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ShL2_RS05690	COG0825	malonyl-CoA metabolic process
ShL2_RS05695	COG0205	6-phosphofructokinase activity
ShL2_RS05700	COG0469	pyruvate kinase activity
ShL2_RS05710	COG1113	amino acid transport
ShL2_RS05715	COG0372	Belongs to the citrate synthase family
ShL2_RS05720	COG0538	isocitrate dehydrogenase activity
ShL2_RS05725	COG0745	RESPONSE REGULATOR receiver
ShL2_RS05730	COG5002	protein histidine kinase activity
ShL2_RS05735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ShL2_RS05735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ShL2_RS05745	COG0237	dephospho-CoA kinase activity
ShL2_RS05755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ShL2_RS05760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ShL2_RS05770	COG1484	DNA-dependent DNA replication
ShL2_RS05775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ShL2_RS05780	COG0833	amino acid
ShL2_RS05785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ShL2_RS05790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ShL2_RS05795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ShL2_RS05800	COG4112	unkown
ShL2_RS05810	COG0544	peptidyl-prolyl cis-trans isomerase activity
ShL2_RS05815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ShL2_RS05825	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ShL2_RS05830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ShL2_RS05835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ShL2_RS05840	COG0181	hydroxymethylbilane synthase activity
ShL2_RS05855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ShL2_RS05865	COG2818	Glycosylase
ShL2_RS05870	COG0525	valine-tRNA ligase activity
ShL2_RS05875	COG0285	dihydrofolate synthase activity
ShL2_RS05880	COG2003	Belongs to the UPF0758 family
ShL2_RS05900	COG1792	Involved in formation and maintenance of cell shape
ShL2_RS05910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ShL2_RS05915	COG2868	ribosomal protein
ShL2_RS05920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ShL2_RS05925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ShL2_RS05930	COG4492	Belongs to the UPF0735 family
ShL2_RS05935	COG0632	four-way junction helicase activity
ShL2_RS05940	COG2255	four-way junction helicase activity
ShL2_RS05945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ShL2_RS05950	COG0343	queuine tRNA-ribosyltransferase activity
ShL2_RS05955	COG1862	Preprotein translocase
ShL2_RS05960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ShL2_RS05960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ShL2_RS05965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ShL2_RS05965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ShL2_RS05970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ShL2_RS05975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ShL2_RS05980	COG1490	D-aminoacyl-tRNA deacylase activity
ShL2_RS05985	COG0860	N-Acetylmuramoyl-L-alanine amidase
ShL2_RS05990	COG0124	histidyl-tRNA synthetase
ShL2_RS05995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ShL2_RS06000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ShL2_RS06005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ShL2_RS06010	COG1959	2 iron, 2 sulfur cluster binding
ShL2_RS06015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ShL2_RS06020	COG1104	cysteine desulfurase activity
ShL2_RS06025	COG0482	sulfurtransferase activity
ShL2_RS06035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ShL2_RS06040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ShL2_RS06045	COG4472	Bacterial protein of unknown function (DUF965)
ShL2_RS06050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ShL2_RS06055	COG3906	Belongs to the UPF0473 family
ShL2_RS06065	COG0826	peptidase U32
ShL2_RS06070	COG0826	peptidase U32
ShL2_RS06075	COG0572	uridine kinase
ShL2_RS06080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ShL2_RS06085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ShL2_RS06090	COG1984	allophanate hydrolase subunit 2
ShL2_RS06095	COG0511	ligase activity, forming carbon-carbon bonds
ShL2_RS06100	COG0439	Biotin carboxylase
ShL2_RS06105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ShL2_RS06110	COG1914	H( )-stimulated, divalent metal cation uptake system
ShL2_RS06115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ShL2_RS06120	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ShL2_RS06125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ShL2_RS06130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ShL2_RS06135	COG1534	Rna-binding protein
ShL2_RS06140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ShL2_RS06145	COG1713	HD superfamily hydrolase involved in NAD metabolism
ShL2_RS06150	COG0799	negative regulation of ribosome biogenesis
ShL2_RS06155	COG2226	methyltransferase
ShL2_RS06165	COG2131	deaminase
ShL2_RS06170	COG0658	competence protein
ShL2_RS06170	COG2333	competence protein COMEC
ShL2_RS06175	COG1466	dna polymerase III delta subunit
ShL2_RS06185	COG0268	Binds directly to 16S ribosomal RNA
ShL2_RS06190	COG0481	GTPase activity
ShL2_RS06195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ShL2_RS06200	COG1420	regulation of RNA biosynthetic process
ShL2_RS06205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ShL2_RS06210	COG0443	Heat shock 70 kDa protein
ShL2_RS06215	COG0484	heat shock protein binding
ShL2_RS06220	COG2264	protein methyltransferase activity
ShL2_RS06225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ShL2_RS06230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ShL2_RS06240	COG1030	water channel activity
ShL2_RS06245	COG4864	UPF0365 protein
ShL2_RS06255	COG1702	phosphate starvation-inducible protein PhoH
ShL2_RS06260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ShL2_RS06265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ShL2_RS06275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ShL2_RS06280	COG1381	Involved in DNA repair and RecF pathway recombination
ShL2_RS06290	COG0517	IMP dehydrogenase activity
ShL2_RS06295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ShL2_RS06305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ShL2_RS06310	COG2384	SAM-dependent methyltransferase
ShL2_RS06315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ShL2_RS06320	COG0513	Belongs to the DEAD box helicase family
ShL2_RS06325	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ShL2_RS06330	COG1121	(ABC) transporter
ShL2_RS06335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ShL2_RS06350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ShL2_RS06355	COG0768	penicillin binding
ShL2_RS06360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ShL2_RS06365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ShL2_RS06375	COG4483	Protein conserved in bacteria
ShL2_RS06380	COG1940	carbohydrate kinase activity
ShL2_RS06385	COG0011	TIGRFAM Protein of
ShL2_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ShL2_RS06395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ShL2_RS06400	COG1459	type II secretion system
ShL2_RS06405	COG4537	Required for transformation and DNA binding
ShL2_RS06425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ShL2_RS06430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ShL2_RS06435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ShL2_RS06440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ShL2_RS06450	COG0095	Lipoate-protein ligase
ShL2_RS06465	COG0006	proline dipeptidase activity
ShL2_RS06470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ShL2_RS06475	COG0511	ligase activity, forming carbon-carbon bonds
ShL2_RS06480	COG0439	Biotin carboxylase
ShL2_RS06485	COG1302	Protein conserved in bacteria
ShL2_RS06490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ShL2_RS06495	COG1570	exodeoxyribonuclease VII activity
ShL2_RS06500	COG1722	exodeoxyribonuclease VII activity
ShL2_RS06510	COG1438	arginine binding
ShL2_RS06515	COG0497	DNA recombination
ShL2_RS06520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ShL2_RS06525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ShL2_RS06530	COG0022	dehydrogenase e1 component
ShL2_RS06535	COG0508	dehydrogenase complex catalyzes the overall conversion of
ShL2_RS06545	COG4129	membrane
ShL2_RS06555	COG2195	Cleaves the N-terminal amino acid of tripeptides
ShL2_RS06565	COG1609	Transcriptional regulator
ShL2_RS06570	COG0366	Alpha amylase catalytic
ShL2_RS06580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ShL2_RS06585	COG1234	tRNA 3'-trailer cleavage
ShL2_RS06590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ShL2_RS06610	COG0300	oxidoreductase activity
ShL2_RS06620	COG0667	Aldo Keto reductase
ShL2_RS06625	COG0494	nUDIX hydrolase
ShL2_RS06630	COG0735	belongs to the Fur family
ShL2_RS06635	COG4974	Belongs to the 'phage' integrase family
ShL2_RS06645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ShL2_RS06650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ShL2_RS06655	COG1187	pseudouridine synthase activity
ShL2_RS06660	COG0745	RESPONSE REGULATOR receiver
ShL2_RS06675	COG1141	Ferredoxin
ShL2_RS06685	COG0514	ATP-dependent DNA helicase (RecQ)
ShL2_RS06690	COG1388	LysM domain
ShL2_RS06705	COG0492	ferredoxin-NADP+ reductase activity
ShL2_RS06715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ShL2_RS06720	COG0539	negative regulation of cytoplasmic translation
ShL2_RS06725	COG1160	GTP binding
ShL2_RS06730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ShL2_RS06750	COG2226	methyltransferase
ShL2_RS06760	COG0105	UTP biosynthetic process
ShL2_RS06765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ShL2_RS06770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ShL2_RS06775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ShL2_RS06780	COG0457	Tetratricopeptide repeat
ShL2_RS06785	COG5582	Belongs to the UPF0302 family
ShL2_RS06790	COG4347	Protein of unknown function (DUF1405)
ShL2_RS06795	COG2738	Putative neutral zinc metallopeptidase
ShL2_RS06800	COG1694	Mazg nucleotide pyrophosphohydrolase
ShL2_RS06805	COG0438	transferase activity, transferring glycosyl groups
ShL2_RS06810	COG0617	tRNA 3'-terminal CCA addition
ShL2_RS06820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ShL2_RS06820	COG1199	ATP-dependent helicase activity
ShL2_RS06825	COG0017	Asparaginyl-tRNA synthetase
ShL2_RS06830	COG3935	DnaD domain protein
ShL2_RS06835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ShL2_RS06845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ShL2_RS06845	COG4499	WXG100 protein secretion system (Wss), protein YukC
ShL2_RS06850	COG3331	DNA recombination
ShL2_RS06860	COG4474	Belongs to the UPF0398 family
ShL2_RS06865	COG3599	regulation of cell shape
ShL2_RS06870	COG0116	Belongs to the methyltransferase superfamily
ShL2_RS06885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ShL2_RS06915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ShL2_RS06920	COG1413	lyase activity
ShL2_RS06925	COG1413	lyase activity
ShL2_RS06935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ShL2_RS06955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ShL2_RS06960	COG2190	(PTS) system
ShL2_RS06965	COG4479	Belongs to the UPF0346 family
ShL2_RS06970	COG0793	Belongs to the peptidase S41A family
ShL2_RS06980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ShL2_RS06985	COG0671	phosphoesterase, PA-phosphatase related
ShL2_RS06990	COG0745	RESPONSE REGULATOR receiver
ShL2_RS06995	COG5002	protein histidine kinase activity
ShL2_RS07000	COG0567	Dehydrogenase, E1 component
ShL2_RS07005	COG0508	dehydrogenase complex catalyzes the overall conversion of
ShL2_RS07025	COG0714	Associated with various cellular activities
ShL2_RS07035	COG1114	Component of the transport system for branched-chain amino acids
ShL2_RS07040	COG3853	Toxic anion resistance protein (TelA)
ShL2_RS07050	COG1254	Belongs to the acylphosphatase family
ShL2_RS07060	COG1278	Cold shock
ShL2_RS07080	COG1473	amidohydrolase
ShL2_RS07085	COG2171	N-acyltransferase activity
ShL2_RS07090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ShL2_RS07095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ShL2_RS07100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ShL2_RS07110	COG0488	(ABC) transporter
ShL2_RS07115	COG2996	Protein conserved in bacteria
ShL2_RS07120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ShL2_RS07125	COG0573	inorganic phosphate transmembrane transporter activity
ShL2_RS07130	COG0581	inorganic phosphate transmembrane transporter activity
ShL2_RS07135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ShL2_RS07140	COG0704	Plays a role in the regulation of phosphate uptake
ShL2_RS07145	COG1164	Oligoendopeptidase f
ShL2_RS07155	COG4607	ABC-type enterochelin transport system periplasmic component
ShL2_RS07160	COG0561	phosphatase activity
ShL2_RS07170	COG2348	transferase activity, transferring amino-acyl groups
ShL2_RS07180	COG0159	tryptophan synthase activity
ShL2_RS07190	COG0135	phosphoribosylanthranilate isomerase activity
ShL2_RS07195	COG0134	indole-3-glycerol-phosphate synthase activity
ShL2_RS07200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ShL2_RS07205	COG0512	Glutamine amidotransferase of anthranilate synthase
ShL2_RS07210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ShL2_RS07215	COG1363	Peptidase, m42
ShL2_RS07220	COG0287	Prephenate dehydrogenase
ShL2_RS07225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ShL2_RS07230	COG1942	4-Oxalocrotonate Tautomerase
ShL2_RS07245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ShL2_RS07245	COG0392	lysyltransferase activity
ShL2_RS07250	COG0628	permease
ShL2_RS07255	COG3711	transcriptional antiterminator
ShL2_RS07260	COG1115	amino acid carrier protein
ShL2_RS07265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ShL2_RS07270	COG0187	DNA topoisomerase II activity
ShL2_RS07275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ShL2_RS07280	COG4841	protein insertion into membrane
ShL2_RS07285	COG0824	Thioesterase
ShL2_RS07290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ShL2_RS07295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ShL2_RS07300	COG1970	mechanosensitive ion channel activity
ShL2_RS07305	COG0419	ATPase involved in DNA repair
ShL2_RS07310	COG0420	3'-5' exonuclease activity
ShL2_RS07315	COG4846	Membrane protein involved in cytochrome C biogenesis
ShL2_RS07330	COG4224	UPF0291 protein
ShL2_RS07340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ShL2_RS07345	COG2340	Cysteine-rich secretory protein family
ShL2_RS07350	COG0516	GMP reductase activity
ShL2_RS07355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ShL2_RS07365	COG0753	catalase activity
ShL2_RS07370	COG0833	amino acid
ShL2_RS07390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ShL2_RS07395	COG0460	homoserine dehydrogenase
ShL2_RS07400	COG0527	aspartate kinase activity
ShL2_RS07430	COG2197	response regulator
ShL2_RS07435	COG4585	Histidine kinase
ShL2_RS07445	COG1131	(ABC) transporter
ShL2_RS07520	COG4824	toxin secretion phage lysis holin
ShL2_RS07615	COG0740	serine-type endopeptidase activity
ShL2_RS07705	COG1484	DNA-dependent DNA replication
ShL2_RS07795	COG0789	Transcriptional regulator
ShL2_RS07800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ShL2_RS07805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ShL2_RS07810	COG0386	Belongs to the glutathione peroxidase family
ShL2_RS07815	COG1923	regulation of RNA biosynthetic process
ShL2_RS07820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ShL2_RS07830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ShL2_RS07835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ShL2_RS07840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ShL2_RS07850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ShL2_RS07855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ShL2_RS07865	COG4550	Control of competence regulator ComK, YlbF/YmcA
ShL2_RS07870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ShL2_RS07880	COG4195	phage-related replication protein
ShL2_RS07885	COG1013	pyruvate-flavodoxin oxidoreductase activity
ShL2_RS07890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ShL2_RS07890	COG0674	pyruvate-flavodoxin oxidoreductase activity
ShL2_RS07895	COG1692	metallophosphoesterase
ShL2_RS07905	COG1418	mRNA catabolic process
ShL2_RS07920	COG0456	acetyltransferase
ShL2_RS07930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ShL2_RS07935	COG1058	Belongs to the CinA family
ShL2_RS07935	COG1546	Belongs to the CinA family
ShL2_RS07955	COG0300	oxidoreductase activity
ShL2_RS07960	COG0612	Peptidase, M16
ShL2_RS07965	COG0612	Peptidase, M16
ShL2_RS07970	COG2188	Transcriptional regulator
ShL2_RS07975	COG1674	ftsk spoiiie
ShL2_RS07980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ShL2_RS07985	COG1185	polyribonucleotide nucleotidyltransferase activity
ShL2_RS07990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ShL2_RS07995	COG0196	riboflavin kinase activity
ShL2_RS08000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ShL2_RS08005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ShL2_RS08010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ShL2_RS08020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ShL2_RS08025	COG0195	Participates in both transcription termination and antitermination
ShL2_RS08030	COG0779	Required for maturation of 30S ribosomal subunits
ShL2_RS08035	COG2176	DNA-directed DNA polymerase activity
ShL2_RS08040	COG0442	prolyl-tRNA aminoacylation
ShL2_RS08050	COG4589	Belongs to the CDS family
ShL2_RS08055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ShL2_RS08065	COG0528	UMP kinase activity
ShL2_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ShL2_RS08075	COG0052	Belongs to the universal ribosomal protein uS2 family
ShL2_RS08080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ShL2_RS08085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ShL2_RS08090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ShL2_RS08095	COG4974	Belongs to the 'phage' integrase family
ShL2_RS08100	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ShL2_RS08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ShL2_RS08110	COG0758	DNA mediated transformation
ShL2_RS08120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ShL2_RS08125	COG0045	succinate-CoA ligase (ADP-forming) activity
ShL2_RS08130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ShL2_RS08145	COG0335	large ribosomal subunit rRNA binding
ShL2_RS08150	COG0336	Belongs to the RNA methyltransferase TrmD family
ShL2_RS08155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ShL2_RS08160	COG0228	four-way junction DNA binding
ShL2_RS08165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ShL2_RS08170	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ShL2_RS08175	COG0552	protein localization to endoplasmic reticulum
ShL2_RS08180	COG1196	nuclear chromosome segregation
ShL2_RS08185	COG0571	ribonuclease III activity
ShL2_RS08190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ShL2_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
ShL2_RS08205	COG0416	fatty acid biosynthetic process
ShL2_RS08210	COG1349	DNA-binding transcription factor activity
ShL2_RS08225	COG1461	Dihydroxyacetone kinase
ShL2_RS08230	COG1302	Protein conserved in bacteria
ShL2_RS08235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ShL2_RS08245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ShL2_RS08250	COG1162	GTPase activity
ShL2_RS08260	COG0631	protein serine/threonine phosphatase activity
ShL2_RS08265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ShL2_RS08270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ShL2_RS08270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ShL2_RS08275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ShL2_RS08290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ShL2_RS08295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ShL2_RS08300	COG1758	RNA polymerase activity
ShL2_RS08305	COG0194	GDP metabolic process
ShL2_RS08325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ShL2_RS08330	COG0284	orotidine-5'-phosphate decarboxylase activity
ShL2_RS08335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ShL2_RS08340	COG0505	Belongs to the CarA family
ShL2_RS08350	COG0540	Belongs to the ATCase OTCase family
ShL2_RS08355	COG2233	PERMEase
ShL2_RS08360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ShL2_RS08365	COG0564	pseudouridine synthase activity
ShL2_RS08370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ShL2_RS08375	COG1388	LysM domain
ShL2_RS08375	COG3942	CHAP domain
ShL2_RS08385	COG0702	epimerase
ShL2_RS08390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ShL2_RS08395	COG3599	regulation of cell shape
ShL2_RS08405	COG0762	integral membrane protein
ShL2_RS08410	COG1799	cell septum assembly
ShL2_RS08415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ShL2_RS08420	COG1496	oxidoreductase activity
ShL2_RS08425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ShL2_RS08430	COG0849	cell division
ShL2_RS08435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ShL2_RS08440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ShL2_RS08445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ShL2_RS08450	COG0768	penicillin binding
ShL2_RS08455	COG4839	cell division protein FtsL
ShL2_RS08460	COG0275	rRNA processing
ShL2_RS08465	COG2001	Belongs to the MraZ family
ShL2_RS08470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ShL2_RS08475	COG0454	-acetyltransferase
ShL2_RS08480	COG1011	Hydrolase
ShL2_RS08520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ShL2_RS08525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ShL2_RS08530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ShL2_RS08535	COG1053	succinate dehydrogenase
ShL2_RS08540	COG2009	succinate dehydrogenase
ShL2_RS08555	COG1193	negative regulation of DNA recombination
ShL2_RS08560	COG1796	DNA polymerase
ShL2_RS08560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ShL2_RS08570	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ShL2_RS08575	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ShL2_RS08580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ShL2_RS08580	COG0072	phenylalanine-tRNA ligase activity
ShL2_RS08585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ShL2_RS08590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ShL2_RS08595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ShL2_RS08605	COG1323	Belongs to the UPF0348 family
ShL2_RS08610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ShL2_RS08615	COG0742	ribosomal rna small subunit methyltransferase
ShL2_RS08625	COG4471	UPF0298 protein
ShL2_RS08635	COG3679	Belongs to the UPF0342 family
ShL2_RS08640	COG2340	Cysteine-rich secretory protein family
ShL2_RS08650	COG0109	protoheme IX farnesyltransferase activity
ShL2_RS08655	COG1612	heme a metabolic process
ShL2_RS08665	COG0772	Belongs to the SEDS family
ShL2_RS08670	COG4838	Belongs to the UPF0358 family
ShL2_RS08675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ShL2_RS08680	COG4896	Protein conserved in bacteria
ShL2_RS08685	COG1217	gtp-binding protein TYPA
ShL2_RS08695	COG0483	inositol monophosphate 1-phosphatase activity
ShL2_RS08700	COG4493	Belongs to the UPF0637 family
ShL2_RS08705	COG1914	H( )-stimulated, divalent metal cation uptake system
ShL2_RS08725	COG1177	transmembrane transport
ShL2_RS08730	COG1176	ABC-type spermidine putrescine transport system, permease component I
ShL2_RS08735	COG3842	ATPase activity
ShL2_RS08740	COG1396	sequence-specific DNA binding
ShL2_RS08740	COG3800	Transcriptional regulator
ShL2_RS08745	COG4476	Belongs to the UPF0223 family
ShL2_RS08775	COG0242	peptide deformylase activity
ShL2_RS08780	COG5503	Protein of unknown function (DUF1447)
ShL2_RS08785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ShL2_RS08795	COG2832	Protein of unknown function (DUF454)
ShL2_RS08800	COG0569	domain protein
ShL2_RS08805	COG1294	oxidase, subunit
ShL2_RS08830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ShL2_RS08845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ShL2_RS08860	COG1122	ATPase activity
ShL2_RS08865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ShL2_RS08870	COG0151	Belongs to the GarS family
ShL2_RS08875	COG0138	bifunctional purine biosynthesis protein purh
ShL2_RS08885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ShL2_RS08895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ShL2_RS08900	COG0047	phosphoribosylformylglycinamidine synthase activity
ShL2_RS08905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ShL2_RS08910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ShL2_RS08915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ShL2_RS08920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ShL2_RS08925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ShL2_RS08940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ShL2_RS08945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ShL2_RS08950	COG1845	cytochrome c oxidase, subunit III
ShL2_RS08955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ShL2_RS08965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ShL2_RS08970	COG1316	TRANSCRIPTIONal
ShL2_RS09000	COG3594	Acyltransferase
ShL2_RS09005	COG0436	Aminotransferase
ShL2_RS09010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ShL2_RS09015	COG0596	Alpha beta hydrolase
ShL2_RS09020	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ShL2_RS09025	COG1169	isochorismate synthase
ShL2_RS09030	COG1575	Belongs to the MenA family. Type 1 subfamily
ShL2_RS09100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ShL2_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ShL2_RS09110	COG0861	Integral membrane protein TerC family
ShL2_RS09125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ShL2_RS09130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ShL2_RS09135	COG2814	Major facilitator Superfamily
ShL2_RS09140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ShL2_RS09145	COG2382	esterase
ShL2_RS09150	COG0628	permease
ShL2_RS09160	COG0475	glutathione-regulated potassium exporter activity
ShL2_RS09160	COG0569	domain protein
ShL2_RS09165	COG2239	Acts as a magnesium transporter
ShL2_RS09170	COG0564	pseudouridine synthase activity
ShL2_RS09175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ShL2_RS09180	COG2357	RelA SpoT domain protein
ShL2_RS09190	COG4116	CYTH
ShL2_RS09195	COG2346	COG2346, Truncated hemoglobins
ShL2_RS09200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ShL2_RS09205	COG1164	Oligoendopeptidase f
ShL2_RS09215	COG4862	establishment of competence for transformation
ShL2_RS09220	COG1393	Belongs to the ArsC family
ShL2_RS09225	COG0180	Tryptophanyl-tRNA synthetase
ShL2_RS09250	COG4166	transmembrane transport
ShL2_RS09255	COG4608	Belongs to the ABC transporter superfamily
ShL2_RS09260	COG0444	Belongs to the ABC transporter superfamily
ShL2_RS09265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ShL2_RS09285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ShL2_RS09295	COG0542	response to heat
ShL2_RS09310	COG0561	phosphatase activity
ShL2_RS09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
ShL2_RS09325	COG0179	Fumarylacetoacetate (FAA) hydrolase
ShL2_RS09330	COG1074	ATP-dependent DNA helicase activity
ShL2_RS09335	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ShL2_RS09350	COG0398	Pfam SNARE associated Golgi protein
ShL2_RS09355	COG0166	Belongs to the GPI family
ShL2_RS09360	COG0137	argininosuccinate synthase activity
ShL2_RS09365	COG0165	Argininosuccinate lyase
ShL2_RS09370	COG0584	glycerophosphoryl diester phosphodiesterase
ShL2_RS09385	COG1902	pentaerythritol trinitrate reductase activity
ShL2_RS09390	COG1098	S1 RNA binding domain
ShL2_RS09395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ShL2_RS09405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ShL2_RS09405	COG2111	Na H antiporter
ShL2_RS09410	COG2111	Na H antiporter
ShL2_RS09415	COG1006	Multisubunit Na H antiporter MnhC subunit
ShL2_RS09420	COG0651	ATP synthesis coupled electron transport
ShL2_RS09425	COG1863	multisubunit Na H antiporter MnhE subunit
ShL2_RS09430	COG2212	antiporter activity
ShL2_RS09435	COG1320	monovalent cation:proton antiporter activity
ShL2_RS09445	COG2050	protein possibly involved in aromatic compounds catabolism
ShL2_RS09450	COG2056	Na+-H+ antiporter family
ShL2_RS09455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ShL2_RS09460	COG1252	NADH dehydrogenase
ShL2_RS09465	COG0316	Belongs to the HesB IscA family
ShL2_RS09470	COG4844	belongs to the
ShL2_RS09475	COG1252	NADH dehydrogenase
ShL2_RS09480	COG4837	Protein of unknown function (DUF1462)
ShL2_RS09485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ShL2_RS09495	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ShL2_RS09500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ShL2_RS09505	COG1696	Membrane protein involved in D-alanine export
ShL2_RS09525	COG0647	UMP catabolic process
ShL2_RS09530	COG2445	Protein of unknown function DUF86
ShL2_RS09540	COG4470	Protein conserved in bacteria
ShL2_RS09545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ShL2_RS09550	COG0737	Belongs to the 5'-nucleotidase family
ShL2_RS09555	COG0730	response to heat
ShL2_RS09560	COG1801	Protein of unknown function DUF72
ShL2_RS09565	COG2070	2-Nitropropane dioxygenase
ShL2_RS09575	COG0719	Fe-S assembly protein
ShL2_RS09580	COG0822	iron-sulfur transferase activity
ShL2_RS09590	COG0719	Fe-S assembly protein
ShL2_RS09595	COG0396	ATPase activity
ShL2_RS09615	COG3237	CsbD-like
ShL2_RS09625	COG2011	ABC-type metal ion transport system permease component
ShL2_RS09630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ShL2_RS09640	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ShL2_RS09645	COG0509	glycine decarboxylation via glycine cleavage system
ShL2_RS09650	COG1393	Belongs to the ArsC family
ShL2_RS09655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ShL2_RS09670	COG1764	response to oxidative stress
ShL2_RS09680	COG1279	arginine transmembrane transporter activity
ShL2_RS09685	COG0406	alpha-ribazole phosphatase activity
ShL2_RS09725	COG0456	acetyltransferase
ShL2_RS09730	COG4195	phage-related replication protein
ShL2_RS09875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ShL2_RS09880	COG0557	exoribonuclease II activity
ShL2_RS09885	COG1647	Serine aminopeptidase, S33
ShL2_RS09890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ShL2_RS09900	COG0148	phosphopyruvate hydratase activity
ShL2_RS09905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ShL2_RS09910	COG0149	triose-phosphate isomerase activity
ShL2_RS09915	COG0126	phosphoglycerate kinase activity
ShL2_RS09925	COG2390	Transcriptional regulator
ShL2_RS09945	COG1090	epimerase
ShL2_RS09950	COG0740	serine-type endopeptidase activity
ShL2_RS09960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ShL2_RS09965	COG1660	Displays ATPase and GTPase activities
ShL2_RS09970	COG0492	ferredoxin-NADP+ reductase activity
ShL2_RS09985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ShL2_RS09990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ShL2_RS09995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ShL2_RS10000	COG0556	nucleotide-excision repair
ShL2_RS10015	COG0300	oxidoreductase activity
ShL2_RS10020	COG1388	LysM domain
ShL2_RS10020	COG3942	CHAP domain
ShL2_RS10030	COG0653	protein targeting
ShL2_RS10035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ShL2_RS10040	COG1040	competence protein
ShL2_RS10055	COG1739	Uncharacterized protein family UPF0029
ShL2_RS10060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ShL2_RS10065	COG2199	diguanylate cyclase activity
ShL2_RS10080	COG2195	Cleaves the N-terminal amino acid of tripeptides
ShL2_RS10085	COG1929	Belongs to the glycerate kinase type-1 family
ShL2_RS10105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ShL2_RS10120	COG4607	ABC-type enterochelin transport system periplasmic component
ShL2_RS10125	COG4604	ABC transporter, ATP-binding protein
ShL2_RS10130	COG4605	iron ion homeostasis
ShL2_RS10135	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS10140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ShL2_RS10145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ShL2_RS10150	COG1780	Probably involved in ribonucleotide reductase function
ShL2_RS10160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ShL2_RS10165	COG3104	oligopeptide transport
ShL2_RS10170	COG1597	lipid kinase activity
ShL2_RS10180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ShL2_RS10185	COG3104	oligopeptide transport
ShL2_RS10190	COG1174	glycine betaine transport
ShL2_RS10200	COG0514	ATP-dependent DNA helicase (RecQ)
ShL2_RS10215	COG1368	sulfuric ester hydrolase activity
ShL2_RS10220	COG1984	allophanate hydrolase subunit 2
ShL2_RS10225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ShL2_RS10245	COG0512	Glutamine amidotransferase of anthranilate synthase
ShL2_RS10245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ShL2_RS10250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ShL2_RS10255	COG0720	synthase
ShL2_RS10260	COG0602	queuosine metabolic process
ShL2_RS10270	COG0463	Glycosyl transferase, family 2
ShL2_RS10280	COG0656	L-ascorbic acid biosynthetic process
ShL2_RS10285	COG1253	flavin adenine dinucleotide binding
ShL2_RS10290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ShL2_RS10290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ShL2_RS10290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ShL2_RS10295	COG1105	Belongs to the carbohydrate kinase PfkB family
ShL2_RS10300	COG1349	DNA-binding transcription factor activity
ShL2_RS10305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ShL2_RS10335	COG0415	Belongs to the DNA photolyase family
ShL2_RS10340	COG0471	metal ion transport
ShL2_RS10350	COG0523	cobalamin synthesis protein
ShL2_RS10360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ShL2_RS10365	COG4988	ABC transporter
ShL2_RS10370	COG1968	undecaprenyl-diphosphatase activity
ShL2_RS10380	COG1671	Belongs to the UPF0178 family
ShL2_RS10385	COG1611	Belongs to the LOG family
ShL2_RS10390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ShL2_RS10405	COG0456	acetyltransferase
ShL2_RS10415	COG2839	Protein conserved in bacteria
ShL2_RS10425	COG0583	DNA-binding transcription factor activity
ShL2_RS10435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ShL2_RS10445	COG0217	transcriptional regulatory protein
ShL2_RS10465	COG3942	CHAP domain
ShL2_RS10465	COG1388	LysM domain
ShL2_RS10470	COG0306	phosphate transporter
ShL2_RS10475	COG1392	Phosphate transport regulator
ShL2_RS10480	COG0577	efflux transmembrane transporter activity
ShL2_RS10485	COG1136	(ABC) transporter
ShL2_RS10490	COG2205	protein histidine kinase activity
ShL2_RS10495	COG0745	RESPONSE REGULATOR receiver
ShL2_RS10500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ShL2_RS10510	COG0657	acetylesterase activity
ShL2_RS10515	COG3949	Membrane
ShL2_RS10525	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ShL2_RS10535	COG2376	Dihydroxyacetone kinase
ShL2_RS10540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS10550	COG1120	ATPase activity
ShL2_RS10555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ShL2_RS10560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ShL2_RS10575	COG1132	(ABC) transporter
ShL2_RS10585	COG1686	Belongs to the peptidase S11 family
ShL2_RS10590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ShL2_RS10600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ShL2_RS10605	COG1682	transport, permease protein
ShL2_RS10610	COG1134	teichoic acid transport
ShL2_RS10615	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ShL2_RS10630	COG1321	iron dependent repressor
ShL2_RS10655	COG1320	monovalent cation:proton antiporter activity
ShL2_RS10660	COG2212	antiporter activity
ShL2_RS10665	COG1863	multisubunit Na H antiporter MnhE subunit
ShL2_RS10670	COG0651	ATP synthesis coupled electron transport
ShL2_RS10675	COG1006	Multisubunit Na H antiporter MnhC subunit
ShL2_RS10680	COG2111	Na H antiporter
ShL2_RS10685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ShL2_RS10685	COG2111	Na H antiporter
ShL2_RS10750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ShL2_RS10755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ShL2_RS10770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ShL2_RS10775	COG0018	arginyl-trna synthetase
ShL2_RS10820	COG1131	(ABC) transporter
ShL2_RS10830	COG3173	Aminoglycoside phosphotransferase
ShL2_RS10840	COG3226	Transcriptional regulator
ShL2_RS10850	COG1012	belongs to the aldehyde dehydrogenase family
ShL2_RS10855	COG1902	pentaerythritol trinitrate reductase activity
ShL2_RS10895	COG0456	acetyltransferase
ShL2_RS10935	COG3093	addiction module antidote protein HigA
ShL2_RS10985	COG1078	dGTPase activity
ShL2_RS10995	COG0655	NAD(P)H dehydrogenase (quinone) activity
ShL2_RS11000	COG0667	Aldo Keto reductase
ShL2_RS11010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ShL2_RS11015	COG1278	Cold shock
ShL2_RS11020	COG4844	belongs to the
ShL2_RS11045	COG0095	Lipoate-protein ligase
ShL2_RS11055	COG3253	May function as heme-dependent peroxidase
ShL2_RS11060	COG2966	Psort location CytoplasmicMembrane, score
ShL2_RS11075	COG2363	Small membrane protein
ShL2_RS11085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ShL2_RS11100	COG0477	Major facilitator Superfamily
ShL2_RS11115	COG0183	Belongs to the thiolase family
ShL2_RS11120	COG0318	PFAM AMP-dependent synthetase and ligase
ShL2_RS11125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ShL2_RS11130	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ShL2_RS11145	COG1469	GTP cyclohydrolase I activity
ShL2_RS11160	COG0431	NADPH-dependent FMN reductase
ShL2_RS11165	COG0561	phosphatase activity
ShL2_RS11175	COG1428	Deoxynucleoside kinase
ShL2_RS11180	COG1428	Deoxynucleoside kinase
ShL2_RS11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ShL2_RS11235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ShL2_RS11240	COG0737	Belongs to the 5'-nucleotidase family
ShL2_RS11265	COG1473	amidohydrolase
ShL2_RS11275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ShL2_RS11280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ShL2_RS11290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ShL2_RS11300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ShL2_RS11310	COG2813	Specifically methylates the guanine in position
ShL2_RS11315	COG0222	ribosome binding
ShL2_RS11320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ShL2_RS11330	COG0081	regulation of translation
ShL2_RS11335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ShL2_RS11340	COG0250	Participates in transcription elongation, termination and antitermination
ShL2_RS11345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ShL2_RS11355	COG3688	RNA-binding protein containing a PIN domain
ShL2_RS11360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ShL2_RS11365	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ShL2_RS11370	COG0215	cysteine-tRNA ligase activity
ShL2_RS11375	COG1045	serine acetyltransferase
ShL2_RS11380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ShL2_RS11385	COG4956	integral membrane protein (PIN domain superfamily)
ShL2_RS11390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ShL2_RS11395	COG0542	response to heat
ShL2_RS11400	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ShL2_RS11405	COG3880	PFAM UvrB UvrC protein
ShL2_RS11410	COG4463	regulation of RNA biosynthetic process
ShL2_RS11415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ShL2_RS11420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ShL2_RS11425	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ShL2_RS11430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ShL2_RS11435	COG2259	Doxx family
ShL2_RS11505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ShL2_RS11510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ShL2_RS11525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ShL2_RS11530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ShL2_RS11535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ShL2_RS11545	COG0037	tRNA processing
ShL2_RS11550	COG1098	S1 RNA binding domain
ShL2_RS11560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ShL2_RS11565	COG3956	TIGRFAM MazG family protein
ShL2_RS11570	COG2244	polysaccharide biosynthetic process
ShL2_RS11575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ShL2_RS11580	COG0193	aminoacyl-tRNA hydrolase activity
ShL2_RS11585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ShL2_RS11590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ShL2_RS11595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ShL2_RS11600	COG2088	sporulation resulting in formation of a cellular spore
ShL2_RS11605	COG0251	oxidation-reduction process
ShL2_RS11610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ShL2_RS11615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ShL2_RS11620	COG4466	Protein conserved in bacteria
ShL2_RS11625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ShL2_RS11630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ShL2_RS11635	COG0084	hydrolase, TatD family'
ShL2_RS11640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ShL2_RS11640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ShL2_RS11645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ShL2_RS11650	COG2827	Endonuclease containing a URI domain
ShL2_RS11655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ShL2_RS11660	COG4467	Involved in initiation control of chromosome replication
ShL2_RS11665	COG1774	PSP1 C-terminal conserved region
ShL2_RS11670	COG0470	DNA polymerase III
ShL2_RS11675	COG3870	Protein conserved in bacteria
ShL2_RS11680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ShL2_RS11685	COG1982	Orn Lys Arg decarboxylase major
ShL2_RS11710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ShL2_RS11720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ShL2_RS11730	COG2188	Transcriptional regulator
ShL2_RS11735	COG0366	Alpha amylase catalytic
ShL2_RS11740	COG1263	PTS System
ShL2_RS11740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ShL2_RS11750	COG0493	'glutamate synthase
ShL2_RS11755	COG0069	glutamate synthase activity
ShL2_RS11755	COG0070	glutamate synthase
ShL2_RS11755	COG0067	glutamate synthase
ShL2_RS11790	COG3942	CHAP domain
ShL2_RS11790	COG1388	LysM domain
ShL2_RS11795	COG0626	cystathionine gamma-synthase activity
ShL2_RS11800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ShL2_RS11815	COG0733	neurotransmitter:sodium symporter activity
ShL2_RS11830	COG1647	Serine aminopeptidase, S33
ShL2_RS11840	COG0671	phosphoesterase, PA-phosphatase related
ShL2_RS11850	COG5609	conserved protein (DUF2294)
ShL2_RS11855	COG3002	Belongs to the UPF0753 family
ShL2_RS11860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ShL2_RS11865	COG3759	membrane
ShL2_RS11875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ShL2_RS11885	COG3728	DNA packaging
ShL2_RS11885	COG5484	DNA packaging
ShL2_RS11905	COG0582	viral genome integration into host DNA
ShL2_RS11910	COG0519	Catalyzes the synthesis of GMP from XMP
ShL2_RS11910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ShL2_RS11915	COG0516	GMP reductase activity
ShL2_RS11915	COG0517	IMP dehydrogenase activity
ShL2_RS11920	COG2233	PERMEase
ShL2_RS11925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ShL2_RS11945	COG1823	symporter activity
ShL2_RS11950	COG0778	Nitroreductase
ShL2_RS11960	COG0450	alkyl hydroperoxide reductase
ShL2_RS11965	COG3634	alkyl hydroperoxide reductase activity
ShL2_RS11975	COG0406	alpha-ribazole phosphatase activity
ShL2_RS11980	COG1280	lysine exporter protein (LysE YggA)
ShL2_RS12040	COG3682	Transcriptional regulator
ShL2_RS12145	COG2217	Heavy metal translocating P-type atpase
ShL2_RS12150	COG1937	Protein conserved in bacteria
ShL2_RS12160	COG1230	cation diffusion facilitator family transporter
ShL2_RS12185	COG1131	(ABC) transporter
ShL2_RS12235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ShL2_RS12245	COG0360	Binds together with S18 to 16S ribosomal RNA
ShL2_RS12260	COG0012	GTP binding
ShL2_RS12265	COG4481	Protein conserved in bacteria
ShL2_RS12270	COG0668	transmembrane transport
ShL2_RS12275	COG1475	DNA binding
ShL2_RS12280	COG0626	cystathionine gamma-synthase activity
ShL2_RS12285	COG0626	cystathionine gamma-synthase activity
ShL2_RS12290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ShL2_RS12290	COG0646	methionine synthase
ShL2_RS12295	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ShL2_RS12310	COG0488	(ABC) transporter
ShL2_RS12320	COG0346	lactoylglutathione lyase activity
ShL2_RS12325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ShL2_RS12350	COG1136	(ABC) transporter
ShL2_RS12355	COG0577	efflux transmembrane transporter activity
ShL2_RS12395	COG0357	Ribosomal RNA small subunit methyltransferase G
ShL2_RS12400	COG0445	tRNA wobble uridine modification
ShL2_RS12405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ShL2_RS12410	COG0594	ribonuclease P activity
ShL2_RS12435	COG2314	TM2 domain
ShL2_RS12480	COG0270	DNA (cytosine-5-)-methyltransferase activity
ShL2_RS12605	COG4485	Bacterial membrane protein, YfhO
ShL2_RS12625	COG4873	Protein conserved in bacteria
ShL2_RS12645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ShL2_RS12645	COG0463	Glycosyl transferase, family 2
ShL2_RS12720	COG0267	Belongs to the bacterial ribosomal protein bL33 family