locus-tag class description D5R78_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D5R78_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D5R78_RS00015 ENOG410848D S4 domain protein YaaA D5R78_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D5R78_RS00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5R78_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5R78_RS00035 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D5R78_RS00040 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D5R78_RS00045 ENOG4108UMN azlc family D5R78_RS00055 ENOG4105DWV Homoserine O-trans-acetylase D5R78_RS00065 ENOG4105BZR domain protein D5R78_RS00070 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D5R78_RS00075 ENOG4105CDU Replicative dna helicase D5R78_RS00080 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D5R78_RS00095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D5R78_RS00100 ENOG4105BZU Histidine kinase D5R78_RS00115 ENOG4105Q2H domain protein D5R78_RS00120 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D5R78_RS00140 ENOG4105C2M dna polymerase I D5R78_RS00155 ENOG4107Y5K Resolvase D5R78_RS00200 ENOG4108BUD transposase D5R78_RS00205 ENOG4108S3A nucleotidyltransferase D5R78_RS00210 ENOG4108BUD transposase D5R78_RS00280 ENOG4105C5H ABC transporter D5R78_RS00320 ENOG4108BUD transposase D5R78_RS00355 ENOG4108BUD transposase D5R78_RS00410 ENOG4105DZR Type I site-specific deoxyribonuclease D5R78_RS00420 ENOG4105CVR type I restriction-modification system D5R78_RS00450 ENOG4107QMH DNA methylase D5R78_RS00475 ENOG4108KD5 ADP-ribosylation crystallin J1 D5R78_RS00485 ENOG4105DE4 1-phosphofructokinase D5R78_RS00490 ENOG4108BUD transposase D5R78_RS00535 ENOG4108UXE Protein tyrosine phosphatase D5R78_RS00550 ENOG4108BUD transposase D5R78_RS00555 ENOG4107RVG penicillin-binding protein D5R78_RS00560 ENOG4108ZMQ domain protein D5R78_RS00565 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D5R78_RS00570 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase D5R78_RS00575 ENOG4108BUD transposase D5R78_RS00585 ENOG41090UD (LipO)protein D5R78_RS00610 ENOG4105W1Y Transcriptional regulator D5R78_RS00625 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein D5R78_RS00645 ENOG4108UXE Protein tyrosine phosphatase D5R78_RS00670 ENOG4105D8X mechanosensitive ion channel D5R78_RS00685 ENOG4105CKI cobalamin synthesis protein D5R78_RS00690 ENOG4105DSE periplasmic solute binding protein D5R78_RS00720 ENOG4105C22 threonyL-tRNA synthetase D5R78_RS00745 ENOG4105H93 Acyltransferase family D5R78_RS00755 ENOG4105DSE periplasmic solute binding protein D5R78_RS00760 ENOG4105CC5 ABC transporter D5R78_RS00765 ENOG4105DIK (ABC) transporter D5R78_RS00770 ENOG4105CKI cobalamin synthesis protein D5R78_RS00775 ENOG4105CWM branched-chain amino acid transport system II carrier protein D5R78_RS00785 ENOG4105DEF Extracellular solute-binding protein, family 5 D5R78_RS00795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5R78_RS00800 ENOG4108JQ5 ABC transporter D5R78_RS00805 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS00830 ENOG4105VUF Transcriptional regulator D5R78_RS00840 ENOG4105C37 (CBS) domain D5R78_RS00845 ENOG4108Z40 Transcriptional regulator D5R78_RS00850 ENOG4108RYK Nad-dependent epimerase dehydratase D5R78_RS00870 ENOG4105C85 amino acid D5R78_RS00895 ENOG4105J1V Triacylglycerol lipase D5R78_RS00920 ENOG4105ETE Transcriptional regulator (LacI family D5R78_RS00925 ENOG4108RVA ribokinase D5R78_RS00930 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) D5R78_RS00935 ENOG4105C2J ABC transporter D5R78_RS00940 ENOG4105CNN ABC, transporter D5R78_RS00945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D5R78_RS00955 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D5R78_RS00960 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D5R78_RS00965 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D5R78_RS00975 ENOG4108VXD carboxy-peptidase D5R78_RS00980 ENOG4106KNT transcriptional regulator D5R78_RS00985 ENOG4105VZJ PTS System D5R78_RS00990 ENOG4105CK1 PTS System D5R78_RS00995 ENOG4105VCP PTS System D5R78_RS01010 ENOG4105RD7 BadF BadG BcrA BcrD D5R78_RS01020 ENOG4105KAF membrAne D5R78_RS01030 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D5R78_RS01035 ENOG4105G7B Protein of unknown function (DUF2992) D5R78_RS01045 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D5R78_RS01065 ENOG4108YYS metal-dependent hydrolase (By similarity) D5R78_RS01085 ENOG4105IE8 Alpha-ketoglutarate permease D5R78_RS01090 ENOG4105CHR reductase D5R78_RS01110 ENOG4105C26 Dehydrogenase D5R78_RS01115 ENOG4105CPQ Dehydrogenase D5R78_RS01120 ENOG4105K56 Transcriptional regulator D5R78_RS01140 ENOG4105C87 Aminotransferase class I and II D5R78_RS01155 ENOG4107RUY (E1 component), alpha subunit D5R78_RS01165 ENOG4107QKR Dehydrogenase D5R78_RS01175 ENOG4105K7K Transcriptional regulator D5R78_RS01190 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) D5R78_RS01195 ENOG4105FR1 rard protein D5R78_RS01205 ENOG4107SJB teichoic acid biosynthesis D5R78_RS01255 ENOG4105W1Y Transcriptional regulator D5R78_RS01275 ENOG4105YB8 TM2 domain containing protein D5R78_RS01285 ENOG4105DBV ornithine carbamoyltransferase D5R78_RS01290 ENOG4105C5B carbamate kinase D5R78_RS01300 ENOG41081XE plasmid maintenance system antidote protein, xre family D5R78_RS01330 ENOG4105DEN Luciferase family D5R78_RS01340 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D5R78_RS01350 ENOG4107QPK )-transporter D5R78_RS01355 ENOG4105JHY Membrane D5R78_RS01360 ENOG4105CFM UPF0317 protein D5R78_RS01370 ENOG4105CE4 GlcNAc 6-P deacetylase D5R78_RS01380 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D5R78_RS01385 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) D5R78_RS01390 ENOG4106KNT transcriptional regulator D5R78_RS01395 ENOG4105DKQ ROK family D5R78_RS01400 ENOG4107SCR N-acetylneuraminate lyase D5R78_RS01405 ENOG4107RJ1 sodium solute D5R78_RS01435 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS01440 ENOG4105C3U ABC transporter D5R78_RS01455 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein D5R78_RS01460 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D5R78_RS01480 ENOG4107QHE Choloylglycine hydrolase D5R78_RS01490 ENOG4105C72 UPF0176 protein D5R78_RS01495 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis D5R78_RS01500 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain D5R78_RS01520 ENOG4105CCI Myosin-Cross-Reactive Antigen D5R78_RS01540 ENOG4105DVE abc transporter atp-binding protein D5R78_RS01550 ENOG4105VZ8 Transcriptional regulator D5R78_RS01555 ENOG41062ES Transcriptional regulator D5R78_RS01560 ENOG4108Q5Y Membrane D5R78_RS01565 ENOG4105F27 Major Facilitator D5R78_RS01575 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D5R78_RS01585 ENOG4105D5T phosphonate abc transporter D5R78_RS01620 ENOG4106YAG Part of the accessory SecA2 SecY2 system specifically required for export of D5R78_RS01625 ENOG4108XJK accessory Sec system protein Asp1 D5R78_RS01630 ENOG41089G2 accessory Sec system protein Asp2 D5R78_RS01635 ENOG4106E62 Accessory Sec system protein Asp3 D5R78_RS01640 ENOG4108MGR Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) D5R78_RS01645 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) D5R78_RS01680 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D5R78_RS01700 ENOG4105E5M Multidrug resistance protein D D5R78_RS01715 ENOG4105EYF MMPL domain protein D5R78_RS01720 ENOG4105DUM transcriptional regulator, lysR family D5R78_RS01725 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D5R78_RS01740 ENOG4105CSX c4-dicarboxylate anaerobic carrier D5R78_RS01745 ENOG4105CI1 PTS System D5R78_RS01750 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase D5R78_RS01750 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase D5R78_RS01785 ENOG4105CEU Arginine dihydrolase D5R78_RS01795 ENOG4105IJS Transcriptional regulator D5R78_RS01805 ENOG4105ETE Transcriptional regulator (LacI family D5R78_RS01815 ENOG4107QPD alcohol dehydrogenase D5R78_RS01820 ENOG4106AKJ D5R78_RS01830 ENOG4107RA9 decarboxylase D5R78_RS01840 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D5R78_RS01880 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D5R78_RS01885 ENOG4105D3Q Sugar transferase D5R78_RS01890 ENOG4105D9U N-acetyltransferase D5R78_RS01930 ENOG4105G6Z alkaline phosphatase D5R78_RS01980 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D5R78_RS01985 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D5R78_RS01990 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D5R78_RS01995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5R78_RS02000 ENOG4108Z73 Siroheme synthase D5R78_RS02005 ENOG410635A Membrane D5R78_RS02010 ENOG4107RIQ Sulfate adenylate transferase D5R78_RS02015 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D5R78_RS02035 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D5R78_RS02040 ENOG4105C94 Transporter D5R78_RS02045 ENOG4105TRT Transcriptional regulator D5R78_RS02055 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) D5R78_RS02090 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D5R78_RS02100 ENOG4107RSM transcriptional regulator D5R78_RS02110 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D5R78_RS02115 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D5R78_RS02120 ENOG4105DWT malate dehydrogenase (quinone) D5R78_RS02130 ENOG4105CS2 ec 3.2.1.21 D5R78_RS02150 ENOG4105WYW fructose-bisphosphate aldolase D5R78_RS02155 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D5R78_RS02180 ENOG4105D01 (LipO)protein D5R78_RS02185 ENOG4108JPW Aminotransferase D5R78_RS02190 ENOG4105CUB amino acid D5R78_RS02200 ENOG4107FQX Alpha-acetolactate decarboxylase D5R78_RS02245 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D5R78_RS02280 ENOG4105VPS UPF0291 protein D5R78_RS02285 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone D5R78_RS02305 ENOG4105CSR polyphosphate kinase 2 D5R78_RS02315 ENOG4105R1C Catalyzes the acylation of glycosyl-4,4'- diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12- methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains (By similarity) D5R78_RS02320 ENOG4105EWK phytoene D5R78_RS02325 ENOG41076QQ Glycosyl transferase, family 2 D5R78_RS02330 ENOG4105FE1 phytoene synthase D5R78_RS02335 ENOG4105EWK phytoene D5R78_RS02350 ENOG41082MP copper ion binding protein D5R78_RS02355 ENOG4105C59 p-type ATPase D5R78_RS02365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D5R78_RS02370 ENOG4108UW5 maltose o-acetyltransferase D5R78_RS02375 ENOG4105C26 Dehydrogenase D5R78_RS02395 ENOG4105D7N magnesium and cobalt transport protein CorA D5R78_RS02405 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D5R78_RS02410 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase D5R78_RS02415 ENOG4105CHU acetyl-coa acetyltransferase D5R78_RS02425 ENOG41068JE domain protein D5R78_RS02435 ENOG4105CMU LysR family (Transcriptional regulator D5R78_RS02440 ENOG4105VAW lrga family D5R78_RS02445 ENOG41067MG lrgb family D5R78_RS02460 ENOG4105CI1 PTS System D5R78_RS02465 ENOG4105CPQ Dehydrogenase D5R78_RS02475 ENOG4105XXY Thioredoxin D5R78_RS02480 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D5R78_RS02490 ENOG4108UZ3 Transporter D5R78_RS02500 ENOG4108MCI Transcriptional regulator, ARAC family D5R78_RS02510 ENOG4105N98 Capsule biosynthesis protein capB D5R78_RS02535 ENOG4105CMG Carbohydrate kinase D5R78_RS02550 ENOG4105EJQ L-serine dehydratase D5R78_RS02565 ENOG4108Z6X (sortase) family D5R78_RS02570 ENOG4108KP7 hydrolase D5R78_RS02585 ENOG4105C26 Dehydrogenase D5R78_RS02595 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase D5R78_RS02610 ENOG4105C26 Dehydrogenase D5R78_RS02615 ENOG41090MY MarR family Transcriptional regulator D5R78_RS02625 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase D5R78_RS02630 ENOG4105FBA Phospholipase Carboxylesterase D5R78_RS02635 ENOG4108K88 Membrane D5R78_RS02645 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 D5R78_RS02650 ENOG4107T5V SNARE associated Golgi D5R78_RS02655 ENOG4105D06 uba thif-type nad fad binding protein D5R78_RS02660 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D5R78_RS02665 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D5R78_RS02670 ENOG41080HI glycine oxidase D5R78_RS02680 ENOG4105DJB Major Facilitator Superfamily D5R78_RS02695 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) D5R78_RS02715 ENOG4105G3Z GntR family transcriptional regulator D5R78_RS02720 ENOG4105CMG Carbohydrate kinase D5R78_RS02725 ENOG4105C6Z Gluconate D5R78_RS02735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D5R78_RS02740 ENOG4105M6F mutator MutT protein D5R78_RS02770 ENOG4105EMU Dehydrogenase D5R78_RS02780 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D5R78_RS02790 ENOG4105CFC Transporter D5R78_RS02795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D5R78_RS02800 ENOG4105CN9 Peptidase m42 family protein D5R78_RS02815 ENOG4105CBC glutamate synthase D5R78_RS02830 ENOG41083J0 (ABC) transporter D5R78_RS02835 ENOG4105C4B ABC transporter, permease D5R78_RS02845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D5R78_RS02855 ENOG4105F27 Major Facilitator D5R78_RS02860 ENOG4105EBR Carboxylesterase D5R78_RS02865 ENOG4107QTZ amino acid D5R78_RS02870 ENOG4105CZ9 Domain of unknown function (DU1801) D5R78_RS02895 ENOG4105R40 Glycine betaine carnitine choline D5R78_RS02900 ENOG41067MG lrgb family D5R78_RS02905 ENOG4105Z9F murein hydrolase regulator LrgA D5R78_RS02910 ENOG4105DY9 regulatoR D5R78_RS02915 ENOG4108HRK Histidine kinase D5R78_RS02925 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D5R78_RS02930 ENOG4105R3P Inner membrane protein yagU D5R78_RS02940 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D5R78_RS02950 ENOG4105C0X amino acid D5R78_RS02955 ENOG4107SUZ Sodium/hydrogen exchanger family D5R78_RS02960 ENOG4105C85 amino acid D5R78_RS02980 ENOG4105DVA methyltransferase D5R78_RS02985 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) D5R78_RS02990 ENOG4105C2C drug resistance transporter, Bcr CflA D5R78_RS03000 ENOG4105BZW Glycerate kinase D5R78_RS03025 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D5R78_RS03040 ENOG4105EAB amino acid AbC transporter D5R78_RS03045 ENOG4105DRP amino acid AbC transporter D5R78_RS03050 ENOG4105CDA abc transporter atp-binding protein D5R78_RS03070 ENOG4105DSE periplasmic solute binding protein D5R78_RS03075 ENOG4108YYC ycei family D5R78_RS03100 ENOG4108IFG nitrite reductase, (NAD(P)H) D5R78_RS03105 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit D5R78_RS03110 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5R78_RS03120 ENOG4108IUE nitrate reductase beta subunit D5R78_RS03125 ENOG4105R3A Nitrate reductase D5R78_RS03140 ENOG4105BZU Histidine kinase D5R78_RS03145 ENOG4105WH1 Two component transcriptional regulator luxr family D5R78_RS03150 ENOG4105DQQ Major facilitator superfamily MFS_1 D5R78_RS03165 ENOG4105K56 Transcriptional regulator D5R78_RS03190 ENOG410606W general stress protein D5R78_RS03195 ENOG4108DMH HTH_ARAC D5R78_RS03220 ENOG4105ECB domain protein D5R78_RS03250 ENOG4105CAY ferredoxin--nadp reductase D5R78_RS03255 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D5R78_RS03265 ENOG410650H (LipO)protein D5R78_RS03270 ENOG4105DBE peroxidase D5R78_RS03275 ENOG4107SJW iron permease, FTR1 D5R78_RS03280 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D5R78_RS03285 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D5R78_RS03295 ENOG4107SJB teichoic acid biosynthesis D5R78_RS03305 ENOG4108I69 Glycosyl transferases group 1 D5R78_RS03310 ENOG4105DWT malate dehydrogenase (quinone) D5R78_RS03325 ENOG4105BZU Histidine kinase D5R78_RS03330 ENOG4105EFI regulatoR D5R78_RS03335 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) D5R78_RS03340 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D5R78_RS03355 ENOG4105T65 Membrane-associated protein D5R78_RS03360 ENOG4105C2C drug resistance transporter, Bcr CflA D5R78_RS03370 ENOG4105CW7 secretion protein, HlyD family D5R78_RS03375 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5R78_RS03400 ENOG4105D7N magnesium and cobalt transport protein CorA D5R78_RS03405 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) D5R78_RS03410 ENOG4105D6U Sodium Glutamate Symporter D5R78_RS03415 ENOG4108VX5 3-methyladenine DNA glycosylase D5R78_RS03430 ENOG4105KK4 UPF0060 membrane protein D5R78_RS03435 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D5R78_RS03440 ENOG4108RPX mosc domain containing protein D5R78_RS03445 ENOG4105E66 phosphoriboisomerase A D5R78_RS03455 ENOG4106E7R Lysostaphin resistance protein A D5R78_RS03460 ENOG41088SP formiminoglutamate hydrolase D5R78_RS03470 ENOG4105CH2 amidohydrolase D5R78_RS03475 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D5R78_RS03480 ENOG4107XC4 flavin reductase domain protein, FMN-binding D5R78_RS03495 ENOG4108Q3X Transcriptional regulator D5R78_RS03500 ENOG4105CI1 PTS System D5R78_RS03510 ENOG4107YBY Hydrolase D5R78_RS03540 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) D5R78_RS03545 ENOG4105C5Y PTS System D5R78_RS03550 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D5R78_RS03565 ENOG4105D29 Helix-turn-helix type 11 domain protein D5R78_RS03580 ENOG4108JB9 formate dehydrogenase D5R78_RS03585 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D5R78_RS03605 ENOG4105C5I Dehydrogenase D5R78_RS03610 ENOG41080TC multidrug resistance protein D5R78_RS03635 ENOG4105DFD Na H antiporter D5R78_RS03645 ENOG41068JE domain protein D5R78_RS03670 ENOG4105FDT acyl-CoA dehydrogenase D5R78_RS03680 ENOG4105DU0 nucleoside hydrolase D5R78_RS03685 ENOG4107ZYJ bioY protein D5R78_RS03695 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D5R78_RS03700 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D5R78_RS03705 ENOG4105E0C molybdate abc transporter D5R78_RS03710 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS03715 ENOG4105D06 uba thif-type nad fad binding protein D5R78_RS03720 ENOG4105EPU Molybdenum cofactor synthesis domain protein D5R78_RS03725 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D5R78_RS03740 ENOG4108ZAF Molybdopterin D5R78_RS03750 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D5R78_RS03755 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D5R78_RS03780 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) D5R78_RS03800 ENOG4107EXU Short-chain dehydrogenase reductase Sdr D5R78_RS03805 ENOG4105CSC Glucose uptake protein D5R78_RS03815 ENOG4105C9U ATP-dependent DNA helicase RecQ D5R78_RS03820 ENOG4105C7N Xanthine uracil vitamin C permease D5R78_RS03830 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D5R78_RS03835 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D5R78_RS03840 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D5R78_RS03845 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D5R78_RS03850 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D5R78_RS03855 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D5R78_RS03860 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D5R78_RS03865 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D5R78_RS03870 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D5R78_RS03875 ENOG41082SA 50s ribosomal protein l29 D5R78_RS03880 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D5R78_RS03885 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D5R78_RS03890 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D5R78_RS03895 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D5R78_RS03905 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D5R78_RS03910 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D5R78_RS03915 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D5R78_RS03920 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D5R78_RS03925 ENOG4105VPB 50S ribosomal protein L30 D5R78_RS03930 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D5R78_RS03935 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D5R78_RS03940 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D5R78_RS03945 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D5R78_RS03955 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D5R78_RS03965 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5R78_RS03970 ENOG4108ZT0 50S ribosomal protein l17 D5R78_RS03975 ENOG4108JJB ABC transporter D5R78_RS03980 ENOG4108JJB ABC transporter D5R78_RS03990 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D5R78_RS03995 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D5R78_RS04000 ENOG4108UJD 30S ribosomal protein S9 D5R78_RS04005 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D5R78_RS04010 ENOG4105E98 transcriptional regulator DeoR family D5R78_RS04030 ENOG4105DE4 1-phosphofructokinase D5R78_RS04035 ENOG4105D2M Aldolase D5R78_RS04040 ENOG4105VCP PTS System D5R78_RS04045 ENOG4105CK1 PTS System D5R78_RS04050 ENOG4105CS2 ec 3.2.1.21 D5R78_RS04060 ENOG4105DEN Luciferase family D5R78_RS04065 ENOG4105CIS alcohol dehydrogenase D5R78_RS04070 ENOG4105C94 Transporter D5R78_RS04085 ENOG4105VBF alkaline shock protein D5R78_RS04110 ENOG4107SFI Major Facilitator superfamily D5R78_RS04120 ENOG4106M28 alanine racemase domain protein D5R78_RS04125 ENOG4108HUF Transporter D5R78_RS04130 ENOG4105DQ5 transport system permease protein D5R78_RS04135 ENOG4108U1V ABC transporter, permease D5R78_RS04140 ENOG4105DWD nucleoside recognition domain protein D5R78_RS04145 ENOG4106EQQ Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) D5R78_RS04150 ENOG4107DUR UPF0457 protein D5R78_RS04155 ENOG4107K5X Membrane-bound metal-dependent hydrolase D5R78_RS04160 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase D5R78_RS04165 ENOG4108UT2 hemolysin iii D5R78_RS04185 ENOG4105D1F ATP-binding protein D5R78_RS04240 ENOG4105C8B TIGR00159 family D5R78_RS04250 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D5R78_RS04260 ENOG4105DKW ABC transporter D5R78_RS04285 ENOG4105PGM cation diffusion facilitator family transporter D5R78_RS04290 ENOG4105KTU Transcriptional regulator, arsr family D5R78_RS04300 ENOG4105DG6 mannose-6-phosphate isomerase D5R78_RS04320 ENOG4108RMU ferritin dps family protein D5R78_RS04325 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D5R78_RS04330 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D5R78_RS04335 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D5R78_RS04340 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D5R78_RS04350 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D5R78_RS04370 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D5R78_RS04385 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D5R78_RS04395 ENOG4105D2N Aldolase D5R78_RS04400 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D5R78_RS04410 ENOG4105C26 Dehydrogenase D5R78_RS04415 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D5R78_RS04420 ENOG41082DI 50s ribosomal protein l31 D5R78_RS04425 ENOG4107104 thymidine kinase D5R78_RS04430 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D5R78_RS04435 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D5R78_RS04440 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D5R78_RS04445 ENOG4107WAU Protein tyrosine phosphatase D5R78_RS04450 ENOG4108UIC UPF0340 protein D5R78_RS04455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D5R78_RS04460 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D5R78_RS04465 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D5R78_RS04475 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) D5R78_RS04480 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D5R78_RS04485 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D5R78_RS04490 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D5R78_RS04495 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D5R78_RS04500 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D5R78_RS04505 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D5R78_RS04510 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D5R78_RS04520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D5R78_RS04525 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D5R78_RS04545 ENOG4105JH5 thiaminase II D5R78_RS04555 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase D5R78_RS04560 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D5R78_RS04565 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) D5R78_RS04580 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D5R78_RS04585 ENOG4105VPX protein, conserved in bacteria D5R78_RS04610 ENOG4105CPF Cell wall formation (By similarity) D5R78_RS04615 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) D5R78_RS04620 ENOG4105C1J atp-dependent rna helicase D5R78_RS04630 ENOG4105CKV Membrane D5R78_RS04635 ENOG410905X membrane-flanked domain protein D5R78_RS04640 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D5R78_RS04645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D5R78_RS04655 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) D5R78_RS04660 ENOG4107SGM protein serine threonine phosphatase D5R78_RS04665 ENOG4105WN5 stage II sporulation protein D5R78_RS04670 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) D5R78_RS04720 ENOG4105C7B Threonine dehydratase D5R78_RS04725 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D5R78_RS04730 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D5R78_RS04735 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D5R78_RS04740 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D5R78_RS04745 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D5R78_RS04750 ENOG4108ZP8 Acetolactate synthase small subunit D5R78_RS04755 ENOG4105C7K acetolactate synthase D5R78_RS04760 ENOG4105C01 Dihydroxy-acid dehydratase D5R78_RS04765 ENOG4105K8N protein family UPF0079, ATPase D5R78_RS04770 ENOG41072GX Peptidase M22 Glycoprotease D5R78_RS04775 ENOG410801F ribosomal-protein-alanine acetyltransferase D5R78_RS04780 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D5R78_RS04785 ENOG4105C5H ABC transporter D5R78_RS04790 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) D5R78_RS04795 ENOG4105CUC YeeE YedE family protein D5R78_RS04805 ENOG4105BZU Histidine kinase D5R78_RS04825 ENOG4108WCX response regulator D5R78_RS04840 ENOG410695V Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) D5R78_RS04845 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D5R78_RS04865 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D5R78_RS04870 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D5R78_RS04875 ENOG4105VTR Integrase D5R78_RS04935 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family D5R78_RS04950 ENOG4105CJ1 ABC, transporter D5R78_RS04990 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D5R78_RS04995 ENOG4105C26 Dehydrogenase D5R78_RS05000 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase D5R78_RS05025 ENOG4105DAP Nicotinate phosphoribosyltransferase D5R78_RS05030 ENOG4107RA1 nh(3)-dependent nad( ) synthetase D5R78_RS05035 ENOG4108U5N UPF0316 protein D5R78_RS05045 ENOG4105C83 adenylosuccinate lyase D5R78_RS05050 ENOG4105KGF protein, YerC YecD D5R78_RS05055 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) D5R78_RS05060 ENOG4105C4R Atp-dependent dna helicase D5R78_RS05065 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D5R78_RS05090 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D5R78_RS05095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D5R78_RS05100 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D5R78_RS05105 ENOG4105CBD Diacylglycerol kinase D5R78_RS05110 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D5R78_RS05120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D5R78_RS05130 ENOG41090A1 ferritin D5R78_RS05145 ENOG4108V3A UPF0421 protein D5R78_RS05150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D5R78_RS05155 ENOG4105EMU Dehydrogenase D5R78_RS05175 ENOG4105ENE Histidine kinase D5R78_RS05180 ENOG4105WH1 Two component transcriptional regulator luxr family D5R78_RS05185 ENOG4107U9T Pfam:Ribonuclease_BN D5R78_RS05195 ENOG4107ZCW Low molecular weight phosphotyrosine protein phosphatase D5R78_RS05210 ENOG4108S4H thioesterase Superfamily protein D5R78_RS05230 ENOG4108Z0Z intracellular protease Pfpi family D5R78_RS05235 ENOG4105BZ4 penicillin-binding protein D5R78_RS05240 ENOG410902V Modulates RecA activity (By similarity) D5R78_RS05250 ENOG4105EY8 ABC transporter D5R78_RS05260 ENOG41067AE Membrane-bound metal-dependent hydrolase D5R78_RS05265 ENOG4105CEN a g-specific adenine glycosylase D5R78_RS05270 ENOG4105EVI UPF0374 protein D5R78_RS05280 ENOG4107NBY Membrane D5R78_RS05285 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D5R78_RS05290 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D5R78_RS05295 ENOG4105C5I Dehydrogenase D5R78_RS05300 ENOG4105G5W regulator Fur family D5R78_RS05480 ENOG4105E5Q amino acid AbC transporter D5R78_RS05485 ENOG4105CDA abc transporter atp-binding protein D5R78_RS05490 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D5R78_RS05500 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D5R78_RS05510 ENOG4105C9Q fumarate hydratase class II D5R78_RS05515 ENOG4108YBP pseudouridine synthase D5R78_RS05520 ENOG4105BZU Histidine kinase D5R78_RS05525 ENOG4105WH1 Two component transcriptional regulator luxr family D5R78_RS05535 ENOG4108UH6 UPF0754 membrane protein D5R78_RS05540 ENOG4105WZB UPF0342 protein D5R78_RS05550 ENOG4106D4I domain protein D5R78_RS05555 ENOG4105EQI Metal Dependent Phosphohydrolase D5R78_RS05560 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) D5R78_RS05575 ENOG4105K59 histidine triad (HIT) protein D5R78_RS05595 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D5R78_RS05600 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D5R78_RS05605 ENOG4105C1Q protoporphyrinogen oxidase D5R78_RS05655 ENOG4105CEY Amp-dependent synthetase and ligase D5R78_RS05665 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D5R78_RS05670 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D5R78_RS05680 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D5R78_RS05685 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D5R78_RS05700 ENOG4106A8V Protein CrcB homolog D5R78_RS05705 ENOG4106A8V Protein CrcB homolog D5R78_RS05715 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D5R78_RS05740 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis D5R78_RS05755 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D5R78_RS05760 ENOG4108R6K riboflavin synthase, subunit alpha D5R78_RS05765 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D5R78_RS05770 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D5R78_RS05780 ENOG4105E8V Alpha Beta Hydrolase Fold protein D5R78_RS05800 ENOG4105N5T Radical SAM Protein D5R78_RS05805 ENOG410605W Major Facilitator D5R78_RS05810 ENOG4105C8T Leucyl-tRNA synthetase D5R78_RS05825 ENOG41063K0 cell wall associated fibronectin-binding protein D5R78_RS05885 ENOG4105CBX hi0933 family D5R78_RS05895 ENOG4105I08 Pseudouridine synthase D5R78_RS05910 ENOG4107QSE Dipeptidase D5R78_RS05915 ENOG4105F0I Aminotransferase D5R78_RS05920 ENOG4108V15 phosphotransferase enzyme family D5R78_RS05925 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D5R78_RS05935 ENOG4105C8F Beta-lactamase domain protein D5R78_RS05955 ENOG4108NKM UPF0354 protein D5R78_RS05960 ENOG4108VDD TRNA binding domain protein D5R78_RS05970 ENOG4105DFU Cell wall formation (By similarity) D5R78_RS05975 ENOG4105MQN general stress protein D5R78_RS05985 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D5R78_RS05990 ENOG4105ETE Transcriptional regulator (LacI family D5R78_RS06000 ENOG4105F1V Acetoin utilization protein D5R78_RS06010 ENOG4105CKU formyltetrahydrofolate synthetase D5R78_RS06020 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D5R78_RS06045 ENOG4105C0H protease D5R78_RS06050 ENOG4105F6E Acyl-transferase D5R78_RS06065 ENOG4108JQ1 Dehydrogenase D5R78_RS06075 ENOG4108X3M OsmC Ohr family protein D5R78_RS06080 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D5R78_RS06085 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D5R78_RS06100 ENOG4105C3J Cysteine desulfurase D5R78_RS06105 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D5R78_RS06110 ENOG4105EJ9 Membrane D5R78_RS06115 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D5R78_RS06125 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D5R78_RS06130 ENOG4107YZX Universal stress protein D5R78_RS06135 ENOG4105DCF alanine dehydrogenase D5R78_RS06140 ENOG4105DC7 peptidase M24 D5R78_RS06145 ENOG4105E8R UPF0173 metal-dependent hydrolase D5R78_RS06160 ENOG4105SFS phosphoesterase RecJ domain protein D5R78_RS06165 ENOG4105C0B DNA polymerase III (alpha subunit) D5R78_RS06170 ENOG4105C6K Malic enzyme D5R78_RS06175 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D5R78_RS06180 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D5R78_RS06185 ENOG4105CTQ phosphohexokinase D5R78_RS06190 ENOG4105CA9 Pyruvate kinase D5R78_RS06205 ENOG4105BZN citrate synthase D5R78_RS06210 ENOG4108HMX isocitrate dehydrogenase (NADP) D5R78_RS06215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D5R78_RS06220 ENOG4105BZU Histidine kinase D5R78_RS06225 ENOG4105C2M dna polymerase I D5R78_RS06235 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D5R78_RS06245 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D5R78_RS06250 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D5R78_RS06265 ENOG4105C22 threonyL-tRNA synthetase D5R78_RS06270 ENOG4108IQI permease D5R78_RS06275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D5R78_RS06280 ENOG4105VJV 50s ribosomal protein L35 D5R78_RS06285 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D5R78_RS06290 ENOG4105U6W MutT NUDIX family protein D5R78_RS06300 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D5R78_RS06305 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D5R78_RS06315 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D5R78_RS06320 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D5R78_RS06330 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D5R78_RS06340 ENOG4105D52 delta-aminolevulinic acid dehydratase D5R78_RS06345 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D5R78_RS06355 ENOG4108R3E Dna-3-methyladenine glycosylase i D5R78_RS06360 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D5R78_RS06365 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D5R78_RS06375 ENOG4105W5Q DNA repair protein (RadC D5R78_RS06395 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D5R78_RS06405 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D5R78_RS06410 ENOG4105X36 (ribosomal) protein D5R78_RS06415 ENOG4105K46 50S ribosomal protein l27 D5R78_RS06420 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D5R78_RS06425 ENOG41090I5 UPF0735 ACT domain-containing protein D5R78_RS06430 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D5R78_RS06435 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D5R78_RS06440 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D5R78_RS06445 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D5R78_RS06450 ENOG4105VIE preprotein translocase, subunit YajC D5R78_RS06455 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D5R78_RS06460 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D5R78_RS06465 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D5R78_RS06470 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D5R78_RS06475 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D5R78_RS06480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D5R78_RS06485 ENOG4105CUT histidyl-tRNA synthetase D5R78_RS06490 ENOG4105C9M aspartyl-trna synthetase D5R78_RS06500 ENOG4105CUZ uba thif-type nad fad binding protein D5R78_RS06505 ENOG4105D1H recombination factor protein RarA D5R78_RS06515 ENOG4105DEN Luciferase family D5R78_RS06520 ENOG4105C3J Cysteine desulfurase D5R78_RS06525 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D5R78_RS06535 ENOG4105C7H Helicase, RecD TraA family D5R78_RS06540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D5R78_RS06545 ENOG4105VBH UPF0297 protein D5R78_RS06550 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D5R78_RS06555 ENOG4105VPH UPF0473 protein D5R78_RS06565 ENOG4105XYU peptidase (U32 family) D5R78_RS06570 ENOG4105CFP Peptidase U32 D5R78_RS06575 ENOG4105DBI uridine monophosphokinase D5R78_RS06580 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D5R78_RS06590 ENOG4105P4J Allophanate hydrolase, subunit 1 D5R78_RS06600 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D5R78_RS06605 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D5R78_RS06610 ENOG4105E7W lamb ycsf family protein D5R78_RS06615 ENOG4105C5A transporter D5R78_RS06620 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D5R78_RS06625 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase D5R78_RS06630 ENOG4105CQW ribosome biogenesis GTPase YqeH D5R78_RS06635 ENOG4105E2X shikimate dehydrogenase D5R78_RS06640 ENOG410812S Rna-binding protein D5R78_RS06645 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D5R78_RS06650 ENOG4108WF2 Metal Dependent Phosphohydrolase D5R78_RS06655 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D5R78_RS06660 ENOG4108D32 Methyltransferase D5R78_RS06665 ENOG4105KQC Competence protein D5R78_RS06670 ENOG4108UK2 deaminase D5R78_RS06675 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 D5R78_RS06680 ENOG4105TQK DNA polymerase iii, delta' subunit D5R78_RS06690 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) D5R78_RS06695 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D5R78_RS06700 ENOG4105CSA Coproporphyrinogen iii oxidase D5R78_RS06705 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D5R78_RS06710 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D5R78_RS06715 ENOG4105CFG Acts as a chaperone (By similarity) D5R78_RS06720 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D5R78_RS06725 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D5R78_RS06730 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D5R78_RS06735 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D5R78_RS06750 ENOG4105F7J membrane-bound serine protease D5R78_RS06755 ENOG4105DI5 UPF0365 protein D5R78_RS06765 ENOG4105C9A Phoh family D5R78_RS06770 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D5R78_RS06775 ENOG4107YR5 Diacylglycerol kinase D5R78_RS06785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D5R78_RS06790 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) D5R78_RS06795 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) D5R78_RS06805 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D5R78_RS06815 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D5R78_RS06825 ENOG4105EGD dinuclear metal center protein, YbgI family D5R78_RS06830 ENOG4105C1J atp-dependent rna helicase D5R78_RS06835 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D5R78_RS06840 ENOG4105FDK ABC transporter D5R78_RS06850 ENOG4105N80 Ferric uptake regulator, Fur family D5R78_RS06860 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D5R78_RS06865 ENOG4107RF6 penicillin-binding protein D5R78_RS06870 ENOG4105WDJ 50S ribosomal protein L33 D5R78_RS06875 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D5R78_RS06900 ENOG4105C5X domain protein D5R78_RS06915 ENOG4106855 Competence protein D5R78_RS06930 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D5R78_RS06935 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D5R78_RS06940 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D5R78_RS06945 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D5R78_RS06950 ENOG4105WZW rhodanese family D5R78_RS06955 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) D5R78_RS06970 ENOG4105DC7 peptidase M24 D5R78_RS06975 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D5R78_RS06985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D5R78_RS06990 ENOG4108ZSR alkaline shock protein D5R78_RS06995 ENOG4105M7K Involved in the transcription termination process (By similarity) D5R78_RS07000 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D5R78_RS07005 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D5R78_RS07015 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) D5R78_RS07020 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D5R78_RS07040 ENOG4105CPP Dehydrogenase, E1 component D5R78_RS07045 ENOG4105C7S Dehydrogenase D5R78_RS07050 ENOG4108Y6J UPF0403 protein D5R78_RS07055 ENOG4108QEG Membrane D5R78_RS07070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D5R78_RS07100 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D5R78_RS07105 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D5R78_RS07110 ENOG4105II7 pyrroline-5-carboxylate reductase D5R78_RS07115 ENOG4105E1F short-chain dehydrogenase reductase D5R78_RS07125 ENOG4105CPC Aldo Keto reductase D5R78_RS07130 ENOG4108YZ4 nudix hydrolase D5R78_RS07135 ENOG4105I3K Ferric uptake regulator, Fur family D5R78_RS07140 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D5R78_RS07150 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D5R78_RS07155 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D5R78_RS07160 ENOG4105FE9 pseudouridine synthase D5R78_RS07165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D5R78_RS07170 ENOG4105BZU Histidine kinase D5R78_RS07190 ENOG4105C9U ATP-dependent DNA helicase RecQ D5R78_RS07195 ENOG4106BU8 elastin-binding protein ebpS D5R78_RS07205 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase D5R78_RS07210 ENOG4105HDK L-asparaginase D5R78_RS07215 ENOG4105CAT Cytidine monophosphate kinase D5R78_RS07220 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D5R78_RS07225 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D5R78_RS07230 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D5R78_RS07235 ENOG4105K70 DNA-binding protein D5R78_RS07250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D5R78_RS07255 ENOG4105EAH synthase D5R78_RS07260 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D5R78_RS07265 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D5R78_RS07270 ENOG4105D49 3-dehydroquinate synthase D5R78_RS07275 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D5R78_RS07280 ENOG41068YB TPR repeat-containing protein D5R78_RS07285 ENOG4105QKB UPF0302 protein D5R78_RS07300 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase D5R78_RS07305 ENOG4105CPK Glycosyl transferase (Group 1 D5R78_RS07310 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D5R78_RS07320 ENOG4105DVT helicase D5R78_RS07325 ENOG4105C5S asparaginyl-tRNA synthetase D5R78_RS07335 ENOG4105CSM endonuclease III D5R78_RS07345 ENOG4105BZ4 penicillin-binding protein D5R78_RS07350 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) D5R78_RS07360 ENOG4108UKS UPF0398 protein D5R78_RS07365 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) D5R78_RS07375 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D5R78_RS07385 ENOG410890F Dynamin family D5R78_RS07430 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein D5R78_RS07435 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein D5R78_RS07440 ENOG4108Y6J UPF0403 protein D5R78_RS07445 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D5R78_RS07450 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D5R78_RS07455 ENOG4108RCR degv family D5R78_RS07465 ENOG4105E0X reductase D5R78_RS07470 ENOG4105C5Y PTS System D5R78_RS07475 ENOG4106E6V UPF0346 protein D5R78_RS07480 ENOG4105CN1 protease D5R78_RS07490 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D5R78_RS07495 ENOG410841Q phosphoesterase PA-phosphatase related protein D5R78_RS07500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D5R78_RS07505 ENOG4105GR3 Histidine kinase D5R78_RS07510 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D5R78_RS07515 ENOG4105C7S Dehydrogenase D5R78_RS07535 ENOG4105GMT ATPase associated with various cellular activities aaa_5 D5R78_RS07540 ENOG4107T89 von Willebrand factor, type A D5R78_RS07545 ENOG4105CWM branched-chain amino acid transport system II carrier protein D5R78_RS07550 ENOG4105CDW Resistance protein D5R78_RS07560 ENOG410855V Acylphosphatase D5R78_RS07570 ENOG4105VEQ Cold shock protein D5R78_RS07580 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D5R78_RS07585 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D5R78_RS07590 ENOG4105CH2 amidohydrolase D5R78_RS07595 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D5R78_RS07600 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D5R78_RS07605 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D5R78_RS07610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D5R78_RS07620 ENOG4105C5H ABC transporter D5R78_RS07625 ENOG4105QNR S1 RNA binding domain protein D5R78_RS07630 ENOG4105CVA phosphate D5R78_RS07635 ENOG4105C8U phosphate abc transporter D5R78_RS07640 ENOG4105E2Z phosphate ABC transporter (Permease D5R78_RS07645 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS07650 ENOG4108UTW Plays a role in the regulation of phosphate uptake D5R78_RS07655 ENOG4105DPN Oligoendopeptidase f D5R78_RS07670 ENOG4108KP7 hydrolase D5R78_RS07675 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) D5R78_RS07680 ENOG4108RMH femAB family D5R78_RS07690 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D5R78_RS07700 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D5R78_RS07705 ENOG4105DK0 Indole-3-glycerol phosphate synthase D5R78_RS07710 ENOG4108I0Q anthranilate phosphoribosyltransferase D5R78_RS07715 ENOG4105DDQ anthranilate synthase D5R78_RS07720 ENOG4105CRQ synthase (Component I) D5R78_RS07725 ENOG4105DER m42 family D5R78_RS07730 ENOG4105EVN Prephenate dehydrogenase D5R78_RS07735 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D5R78_RS07740 ENOG41069HH 4-oxalocrotonate tautomerase D5R78_RS07745 ENOG4108RCF TRANSCRIPTIONal D5R78_RS07750 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D5R78_RS07755 ENOG4105FF5 Membrane D5R78_RS07765 ENOG4105CID antiterminator D5R78_RS07775 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5R78_RS07780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5R78_RS07785 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D5R78_RS07800 ENOG4108I0Z Aconitate hydratase D5R78_RS07805 ENOG4105C94 Transporter D5R78_RS07810 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D5R78_RS07815 ENOG4105EYH Exonuclease D5R78_RS07820 ENOG4107RFY SbcCD D subunit D5R78_RS07840 ENOG4105VPS UPF0291 protein D5R78_RS07850 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D5R78_RS07855 ENOG4106UY4 Inherit from COG: Scp-like extracellular D5R78_RS07860 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) D5R78_RS07865 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D5R78_RS07875 ENOG4105CH6 catalase D5R78_RS07880 ENOG4108IQI permease D5R78_RS07895 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D5R78_RS07900 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) D5R78_RS07905 ENOG4105D6E homoserine dehydrogenase D5R78_RS07910 ENOG4105CFH Aspartokinase D5R78_RS07945 ENOG4108S01 response regulator D5R78_RS07950 ENOG4105BZU Histidine kinase D5R78_RS07960 ENOG4108M15 ABC transporter D5R78_RS07965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D5R78_RS08030 ENOG4105XSJ toxin secretion phage lysis holin D5R78_RS08065 ENOG4108FKH Transglycosylase SLT domain D5R78_RS08125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D5R78_RS08240 ENOG4108UUM single-stranded DNA-binding protein D5R78_RS08300 ENOG4105KV4 Transcriptional regulator D5R78_RS08305 ENOG4105CXI aluminum resistance protein D5R78_RS08310 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D5R78_RS08315 ENOG4108V06 Glutathione peroxidase D5R78_RS08320 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D5R78_RS08325 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D5R78_RS08335 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D5R78_RS08340 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D5R78_RS08355 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D5R78_RS08360 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D5R78_RS08375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D5R78_RS08385 ENOG4105K7W phage-related replication protein D5R78_RS08390 ENOG4105DQU oxidoreductase, subunit beta D5R78_RS08395 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein D5R78_RS08400 ENOG4105D48 metallophosphoesterase D5R78_RS08410 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) D5R78_RS08420 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) D5R78_RS08425 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D5R78_RS08435 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D5R78_RS08440 ENOG4105CEV competence damage-inducible protein D5R78_RS08445 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D5R78_RS08460 ENOG4108RKS Short-chain dehydrogenase reductase Sdr D5R78_RS08475 ENOG4105FDP GntR family transcriptional regulator D5R78_RS08480 ENOG4105CNU cell division protein FtsK D5R78_RS08485 ENOG4105CN5 Metallo-Beta-Lactamase D5R78_RS08490 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D5R78_RS08495 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D5R78_RS08500 ENOG4105DTN riboflavin biosynthesis protein ribF D5R78_RS08505 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D5R78_RS08510 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D5R78_RS08520 ENOG4105VHM ribosomal protein D5R78_RS08525 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination D5R78_RS08530 ENOG4105CHV Transcription elongation factor NusA D5R78_RS08535 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D5R78_RS08540 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D5R78_RS08545 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D5R78_RS08550 ENOG4105DZP Membrane-associated zinc metalloprotease D5R78_RS08555 ENOG4105KNE Phosphatidate cytidylyltransferase D5R78_RS08560 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D5R78_RS08565 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D5R78_RS08570 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D5R78_RS08575 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D5R78_RS08580 ENOG4105CE9 30S ribosomal protein S2 D5R78_RS08585 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) D5R78_RS08590 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D5R78_RS08595 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D5R78_RS08600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D5R78_RS08605 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) D5R78_RS08610 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D5R78_RS08620 ENOG4105C79 DNA protecting protein DprA D5R78_RS08630 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D5R78_RS08635 ENOG4105CMV Succinyl-CoA synthetase subunit beta D5R78_RS08640 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D5R78_RS08650 ENOG4105EJV Membrane D5R78_RS08660 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D5R78_RS08665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D5R78_RS08670 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D5R78_RS08675 ENOG4105K5M 30s ribosomal protein S16 D5R78_RS08685 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) D5R78_RS08690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D5R78_RS08695 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D5R78_RS08700 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D5R78_RS08705 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D5R78_RS08710 ENOG4105CHR reductase D5R78_RS08720 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D5R78_RS08725 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) D5R78_RS08730 ENOG4105CB5 ATP-dependent DNA helicase recG D5R78_RS08735 ENOG4107Y9E nuclease D5R78_RS08740 ENOG4105DP4 dak2 domain fusion protein ylov D5R78_RS08745 ENOG4108ZAA Alkaline-shock protein D5R78_RS08750 ENOG4105VB9 50S ribosomal protein l28 D5R78_RS08760 ENOG4105FJ0 thiamine D5R78_RS08765 ENOG4105DJV ribulose-phosphate 3-epimerase D5R78_RS08770 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D5R78_RS08780 ENOG4108ZF3 Phosphatase D5R78_RS08785 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D5R78_RS08790 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D5R78_RS08795 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D5R78_RS08800 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D5R78_RS08810 ENOG4105C25 Primosomal protein n' D5R78_RS08815 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D5R78_RS08820 ENOG41067UH Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D5R78_RS08825 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D5R78_RS08845 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D5R78_RS08850 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D5R78_RS08855 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D5R78_RS08860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D5R78_RS08865 ENOG4105CD3 dihydroorotase D5R78_RS08870 ENOG4105CXT aspartate transcarbamylase D5R78_RS08880 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) D5R78_RS08885 ENOG4105C34 Pseudouridine synthase D5R78_RS08890 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D5R78_RS08895 ENOG4105VRS hydrolase family 18 D5R78_RS08905 ENOG4105CGD Nad-dependent epimerase dehydratase D5R78_RS08910 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D5R78_RS08925 ENOG41067XK integral membrane protein D5R78_RS08930 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) D5R78_RS08935 ENOG4105DFA alanine racemase domain protein D5R78_RS08940 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D5R78_RS08945 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D5R78_RS08950 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D5R78_RS08955 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) D5R78_RS08960 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D5R78_RS08965 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D5R78_RS08970 ENOG4105CJN penicillin-binding protein D5R78_RS08975 ENOG41068DC Essential cell division protein (By similarity) D5R78_RS08980 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D5R78_RS08985 ENOG4108V6E Cell division protein mraZ D5R78_RS08990 ENOG41074B2 UPF0747 protein D5R78_RS08995 ENOG4108YG3 N-acetyltransferase D5R78_RS09040 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D5R78_RS09045 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D5R78_RS09050 ENOG4105E33 succinate dehydrogenase D5R78_RS09060 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit D5R78_RS09065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D5R78_RS09070 ENOG4105K63 Thioredoxin D5R78_RS09075 ENOG4105C98 muts2 protein D5R78_RS09080 ENOG4105DCG PHP domain protein D5R78_RS09090 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) D5R78_RS09095 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D5R78_RS09100 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D5R78_RS09105 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D5R78_RS09110 ENOG4108RWN rrna methyltransferase D5R78_RS09115 ENOG41067VY 50S ribosomal protein L32 D5R78_RS09125 ENOG4105CDE UPF0348 protein D5R78_RS09130 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D5R78_RS09135 ENOG4106H78 methyltransferase D5R78_RS09145 ENOG4105WUC UPF0298 protein D5R78_RS09160 ENOG4106UY4 Inherit from COG: Scp-like extracellular D5R78_RS09170 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D5R78_RS09175 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) D5R78_RS09185 ENOG4105CNI cell division protein FtsW D5R78_RS09190 ENOG4105ZPI UPF0358 protein D5R78_RS09205 ENOG4105CI3 gtp-binding protein typa D5R78_RS09215 ENOG4105ECY inositol monophosphatase D5R78_RS09220 ENOG4108WQ8 UPF0637 protein D5R78_RS09225 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D5R78_RS09240 ENOG4108HM4 ABC transporter D5R78_RS09245 ENOG4105D38 putrescine abc transporter D5R78_RS09255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS09260 ENOG4105CFF transcriptional regulator D5R78_RS09265 ENOG4105WBI UPF0223 protein D5R78_RS09270 ENOG4107QN2 dihydrolipoyl dehydrogenase D5R78_RS09275 ENOG4105C7S Dehydrogenase D5R78_RS09280 ENOG4105CPP Dehydrogenase, E1 component D5R78_RS09295 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D5R78_RS09300 ENOG4106148 UPF0356 protein D5R78_RS09305 ENOG4105CN5 Metallo-Beta-Lactamase D5R78_RS09315 ENOG4105WD1 Membrane D5R78_RS09320 ENOG4107ZYR domain protein D5R78_RS09350 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D5R78_RS09355 ENOG4105KRI phosphocarrier protein (HPr D5R78_RS09365 ENOG4105DR4 Methyltransferase D5R78_RS09380 ENOG4108JJB ABC transporter D5R78_RS09385 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) D5R78_RS09390 ENOG4105C12 Phosphoribosylglycinamide synthetase D5R78_RS09395 ENOG4105DC1 bifunctional purine biosynthesis protein purh D5R78_RS09400 ENOG4108V3E phosphoribosylglycinamide formyltransferase D5R78_RS09405 ENOG4105CXB phosphoribosylaminoimidazole synthetase D5R78_RS09410 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D5R78_RS09415 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii D5R78_RS09420 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I D5R78_RS09425 ENOG4105VR9 phosphoribosylformylglycinamidine synthase D5R78_RS09430 ENOG4105C8V SAICAR synthetase D5R78_RS09435 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D5R78_RS09440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D5R78_RS09445 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D5R78_RS09470 ENOG4105E2S oxidase) subunit II D5R78_RS09475 ENOG4105BZ9 Cytochrome C oxidase, subunit I D5R78_RS09480 ENOG4105CCU oxidase (Subunit III) D5R78_RS09485 ENOG41060D1 Quinol oxidase D5R78_RS09495 ENOG4105FQP Beta-lactamase D5R78_RS09500 ENOG4108KGH TRANSCRIPTIONal D5R78_RS09510 ENOG4108HPG -acetyltransferase D5R78_RS09515 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis D5R78_RS09530 ENOG4108TGC Acyltransferase D5R78_RS09535 ENOG4105CHM Aminotransferase D5R78_RS09540 ENOG4108IPT Naphthoate synthase D5R78_RS09545 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D5R78_RS09550 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D5R78_RS09555 ENOG4105E4F Isochorismate synthase D5R78_RS09560 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D5R78_RS09650 ENOG4107TS3 membrane protein, TerC D5R78_RS09655 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D5R78_RS09665 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D5R78_RS09675 ENOG4108QBV Monogalactosyldiacylglycerol synthase D5R78_RS09680 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence D5R78_RS09695 ENOG4105C02 permease D5R78_RS09710 ENOG4105CJW magnesium transporter D5R78_RS09715 ENOG4105EMS pseudouridine synthase D5R78_RS09720 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D5R78_RS09730 ENOG4106EFP UPF0738 protein D5R78_RS09735 ENOG4105MIX Adenylate cyclase D5R78_RS09740 ENOG4108Z18 K06886 hemoglobin D5R78_RS09745 ENOG4105T58 Dithiol-disulfide isomerase D5R78_RS09750 ENOG4105DPN Oligoendopeptidase f D5R78_RS09760 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis D5R78_RS09765 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) D5R78_RS09770 ENOG4105C31 Tryptophanyl-tRNA synthetase D5R78_RS09785 ENOG4108J59 Extracellular solute-binding protein, family 5 D5R78_RS09790 ENOG4108JQ7 (ABC) transporter D5R78_RS09800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5R78_RS09805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D5R78_RS09820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D5R78_RS09830 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5R78_RS09845 ENOG4108KP7 hydrolase D5R78_RS09850 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase D5R78_RS09855 ENOG4106BKT UPF0344 protein D5R78_RS09860 ENOG4105ERH Fumarylacetoacetate hydrolase D5R78_RS09865 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D5R78_RS09870 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination D5R78_RS09890 ENOG4107QYV phosphohexose isomerase D5R78_RS09895 ENOG4105CDH Citrulline--aspartate ligase D5R78_RS09900 ENOG4105CH7 arginosuccinase D5R78_RS09905 ENOG4107VXM glycerophosphoryl diester phosphodiesterase D5R78_RS09910 ENOG4105D82 Glutamate dehydrogenase D5R78_RS09915 ENOG4105C8Y Acetylornithine aminotransferase D5R78_RS09920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D5R78_RS09925 ENOG41060GV RNA binding s1 domain protein D5R78_RS09930 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D5R78_RS09940 ENOG4105D65 subunit l D5R78_RS09950 ENOG4105MKQ Monovalent cation H antiporter subunit C D5R78_RS09955 ENOG4108JPZ Monovalent cation H antiporter subunit D D5R78_RS09960 ENOG4105SC1 monovalent cation H antiporter subunit E D5R78_RS09965 ENOG4105W4C monovalent cation H antiporter subunit F D5R78_RS09970 ENOG4105KJM monovalent cation h antiporter subunit g D5R78_RS09980 ENOG4105KA0 thioesterase Superfamily protein D5R78_RS09985 ENOG4105D3Y Na H antiporter D5R78_RS09990 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D5R78_RS09995 ENOG4105CEP NADH dehydrogenase D5R78_RS10000 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D5R78_RS10005 ENOG4105ZKE UPF0349 protein D5R78_RS10020 ENOG41083MR nifu domain-containing protein D5R78_RS10030 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD D5R78_RS10035 ENOG4106C1H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) D5R78_RS10040 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D5R78_RS10045 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) D5R78_RS10060 ENOG4105D4U had-superfamily hydrolase, subfamily iia D5R78_RS10075 ENOG4105MMD transcriptional regulator D5R78_RS10080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D5R78_RS10085 ENOG4107R8B 5'-nucleotidase D5R78_RS10095 ENOG4105I3N Conserved Protein D5R78_RS10100 ENOG4105EA8 2-Nitropropane dioxygenase D5R78_RS10110 ENOG4105DIW FeS assembly protein SUFB D5R78_RS10115 ENOG4108UNV SUF system FeS assembly protein, NifU family D5R78_RS10120 ENOG4105C9B Cysteine desulfurase D5R78_RS10125 ENOG4105JRK feS assembly protein SufD D5R78_RS10130 ENOG4105C3K feS assembly ATPase SufC D5R78_RS10145 ENOG41061M1 UPF0337 protein D5R78_RS10150 ENOG4105D01 (LipO)protein D5R78_RS10155 ENOG4108UMI ABC transporter, permease D5R78_RS10160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D5R78_RS10175 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D5R78_RS10180 ENOG41080E8 Transcriptional regulator, Spx MgsR family D5R78_RS10185 ENOG4105SZ6 Thioredoxin D5R78_RS10195 ENOG4105FF2 Type I DHQase D5R78_RS10200 ENOG4108ZHJ Organic hydroperoxide resistance protein D5R78_RS10210 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D5R78_RS10215 ENOG4105CVJ phosphoglycerate mutase D5R78_RS10255 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) D5R78_RS10260 ENOG4105K7W phage-related replication protein D5R78_RS10310 ENOG4108TFU terminase (Small subunit) D5R78_RS10415 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase D5R78_RS10460 ENOG4105E4C Lytic transglycosylase catalytic D5R78_RS10505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D5R78_RS10570 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D5R78_RS10635 ENOG4105CDU Replicative dna helicase D5R78_RS10655 ENOG4108UUM single-stranded DNA-binding protein D5R78_RS10705 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D5R78_RS10725 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D5R78_RS10730 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D5R78_RS10740 ENOG4105XZU Preprotein translocase, subunit SecG D5R78_RS10750 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D5R78_RS10755 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D5R78_RS10760 ENOG4105CP7 Triose-phosphate isomerase D5R78_RS10765 ENOG4105BZA Phosphoglycerate kinase D5R78_RS10770 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D5R78_RS10795 ENOG4105ECP epimerase D5R78_RS10805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D5R78_RS10810 ENOG4105CIE May be required for sporulation (By similarity) D5R78_RS10815 ENOG4105CHW UPF0052 protein D5R78_RS10820 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D5R78_RS10825 ENOG4105C3M thioredoxin reductase D5R78_RS10835 ENOG4108S4C acetyltransferase D5R78_RS10840 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D5R78_RS10845 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D5R78_RS10850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D5R78_RS10855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D5R78_RS10870 ENOG4105E1F short-chain dehydrogenase reductase D5R78_RS10875 ENOG41068JE domain protein D5R78_RS10885 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D5R78_RS10890 ENOG4105MS2 ribosomal subunit Interface protein D5R78_RS10895 ENOG41081UC Inherit from COG: Competence protein D5R78_RS10905 ENOG4105EPR degv family D5R78_RS10910 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D5R78_RS10915 ENOG4105ESV Glycosyl transferase, family 4 D5R78_RS10920 ENOG4105BZU Histidine kinase D5R78_RS10935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D5R78_RS10940 ENOG4105BZW Glycerate kinase D5R78_RS10960 ENOG4105D4A Cell wall formation (By similarity) D5R78_RS10980 ENOG4108IPW abc transporter atp-binding protein D5R78_RS10985 ENOG4105CM4 permease protein D5R78_RS10990 ENOG4105DHS permease protein D5R78_RS10995 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D5R78_RS11000 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D5R78_RS11005 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D5R78_RS11015 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D5R78_RS11020 ENOG4105DUX Transporter D5R78_RS11025 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) D5R78_RS11030 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C D5R78_RS11035 ENOG4105CIH Imidazole acetol-phosphate transaminase D5R78_RS11040 ENOG4105DUX Transporter D5R78_RS11045 ENOG4105E90 ABC transporter D5R78_RS11055 ENOG4105C9U ATP-dependent DNA helicase RecQ D5R78_RS11060 ENOG4105C5H ABC transporter D5R78_RS11075 ENOG4105E0M Sulfatase D5R78_RS11080 ENOG4107R7A Allophanate hydrolase subunit 2 D5R78_RS11085 ENOG4105P4J Allophanate hydrolase, subunit 1 D5R78_RS11105 ENOG4105DDQ anthranilate synthase D5R78_RS11110 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D5R78_RS11115 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase D5R78_RS11120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D5R78_RS11130 ENOG4105CKK Glycosyl transferase, family 2 D5R78_RS11145 ENOG4105C37 (CBS) domain D5R78_RS11150 ENOG4105DM4 PTS System D5R78_RS11155 ENOG4105DE4 1-phosphofructokinase D5R78_RS11160 ENOG4105E98 transcriptional regulator DeoR family D5R78_RS11165 ENOG4108Z66 YbaK ebsC protein D5R78_RS11175 ENOG4105DP8 Major facilitator superfamily MFS_1 D5R78_RS11195 ENOG4105CVP deoxyribo-dipyrimidine photolyase D5R78_RS11200 ENOG4107QPK )-transporter D5R78_RS11210 ENOG4105CKI cobalamin synthesis protein D5R78_RS11215 ENOG4105K56 Transcriptional regulator D5R78_RS11220 ENOG4108JJ8 (ABC) transporter D5R78_RS11225 ENOG4108JJ9 ABC, transporter D5R78_RS11230 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D5R78_RS11240 ENOG4107XJU UPF0178 protein D5R78_RS11245 ENOG4108URH decarboxylase D5R78_RS11265 ENOG4105WQG acetyltransferase D5R78_RS11275 ENOG4105SXS Protein of unknown function (DUF456) D5R78_RS11305 ENOG4105CDY transcriptional regulatory protein D5R78_RS11325 ENOG4105VRS hydrolase family 18 D5R78_RS11330 ENOG4105CJ3 phosphate transporter D5R78_RS11335 ENOG4107GRR phosphate transport regulator D5R78_RS11345 ENOG4105C19 ABC transporter D5R78_RS11350 ENOG4105EWM Histidine kinase D5R78_RS11355 ENOG4105CJZ response regulator D5R78_RS11375 ENOG4108K88 Membrane D5R78_RS11385 ENOG4105VDH Dihydroxyacetone kinase D5R78_RS11395 ENOG4105CMT Dihydroxyacetone kinase D5R78_RS11400 ENOG4105EHG Permease protein D5R78_RS11405 ENOG4105DQ5 transport system permease protein D5R78_RS11410 ENOG4105E0A ABC, transporter D5R78_RS11415 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) D5R78_RS11425 ENOG4107SJB teichoic acid biosynthesis D5R78_RS11435 ENOG4105BZ1 (ABC) transporter D5R78_RS11450 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase D5R78_RS11470 ENOG4105EY8 ABC transporter D5R78_RS11475 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D5R78_RS11485 ENOG4107R5H iron (metal) dependent repressor, dtxr family D5R78_RS11490 ENOG4105EEQ Na H antiporter D5R78_RS11510 ENOG4105KJM monovalent cation h antiporter subunit g D5R78_RS11515 ENOG410684G monovalent cation H antiporter subunit F D5R78_RS11520 ENOG4105IMY monovalent cation H antiporter subunit E D5R78_RS11525 ENOG4108JPZ Monovalent cation H antiporter subunit D D5R78_RS11535 ENOG4108PMQ Na H antiporter MnhB subunit-related protein D5R78_RS11540 ENOG4105C8S subunit m D5R78_RS11595 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D5R78_RS11600 ENOG4105EHG Permease protein D5R78_RS11605 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D5R78_RS11625 ENOG4105C75 arginyL-tRNA synthetase D5R78_RS11705 ENOG4108BUD transposase D5R78_RS11710 ENOG4108XFG YwhD family D5R78_RS11715 ENOG4105DCI Phosphohydrolase D5R78_RS11725 ENOG4108WS4 fmn reductase D5R78_RS11730 ENOG4105CPC Aldo Keto reductase D5R78_RS11740 ENOG4107QN2 dihydrolipoyl dehydrogenase D5R78_RS11745 ENOG4105VEQ Cold shock protein D5R78_RS11750 ENOG4105QAT UPF0741 protein D5R78_RS11775 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) D5R78_RS11780 ENOG4108IJ2 phosphate acetyltransferase D5R78_RS11785 ENOG4107JTW chlorite dismutase D5R78_RS11790 ENOG4105DWK Membrane D5R78_RS11805 ENOG4105M08 Membrane D5R78_RS11815 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D5R78_RS11820 ENOG4105DWF phosphomethylpyrimidine kinase D5R78_RS11845 ENOG4105CHU acetyl-coa acetyltransferase D5R78_RS11850 ENOG4107F3J Amp-dependent synthetase and ligase D5R78_RS11900 ENOG41080HJ 6-phospho 3-hexuloisomerase D5R78_RS11905 ENOG4108VA3 3-hexulose-6-phosphate synthase D5R78_RS11915 ENOG4107YEI lmbE family D5R78_RS11920 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) D5R78_RS11960 ENOG4107YFT Nadph-dependent fmn reductase D5R78_RS11965 ENOG410667J hydrolase D5R78_RS11970 ENOG4108Z6B deaminase D5R78_RS11980 ENOG4105ZMH deoxynucleoside kinase D5R78_RS12025 ENOG4105CM2 brancheD-chain amino acid aminotransferase D5R78_RS12030 ENOG4105EXW epimerase dehydratase D5R78_RS12035 ENOG4105CGH 5'-nucleotidase D5R78_RS12070 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D5R78_RS12075 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D5R78_RS12085 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D5R78_RS12095 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5R78_RS12100 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5R78_RS12105 ENOG4107Y49 methyltransferase D5R78_RS12110 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D5R78_RS12115 ENOG4108VZM 50s ribosomal protein L10 D5R78_RS12125 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D5R78_RS12130 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D5R78_RS12135 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D5R78_RS12140 ENOG410683Z Preprotein translocase SecE subunit D5R78_RS12155 ENOG4105M0M Tetracycline resistance protein D5R78_RS12160 ENOG4105C2N RNA methyltransferase TrmH family group 3 D5R78_RS12165 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) D5R78_RS12170 ENOG4105C8N cysteinyl-tRNA synthetase D5R78_RS12175 ENOG4105D7W serine acetyltransferase D5R78_RS12180 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D5R78_RS12185 ENOG4105CTP PilT protein domain protein D5R78_RS12190 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D5R78_RS12195 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5R78_RS12200 ENOG41066A3 ATP guanido phosphotransferase D5R78_RS12205 ENOG4108Z0C Uvrb UvrC protein D5R78_RS12210 ENOG4105KEX transcriptional regulator, ctsr D5R78_RS12215 ENOG4105D9N nucleoside D5R78_RS12220 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) D5R78_RS12225 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) D5R78_RS12230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D5R78_RS12320 ENOG4105CRK lysyL-tRNA synthetase D5R78_RS12325 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D5R78_RS12330 ENOG4105KRF dihydroneopterin aldolase D5R78_RS12340 ENOG4105C6T cysteine synthase D5R78_RS12345 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D5R78_RS12350 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D5R78_RS12355 ENOG4108UGV hypoxanthine phosphoribosyltransferase D5R78_RS12360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D5R78_RS12365 ENOG41060GV RNA binding s1 domain protein D5R78_RS12375 ENOG41082I2 s4 domain protein D5R78_RS12380 ENOG4108IY2 MazG family D5R78_RS12390 ENOG4108JA2 transcriptioN-repair coupling factor D5R78_RS12395 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D5R78_RS12400 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D5R78_RS12405 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D5R78_RS12410 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D5R78_RS12415 ENOG4105K4W Could be involved in septation (By similarity) D5R78_RS12420 ENOG4105KME endoribonuclease L-psp D5R78_RS12425 ENOG4105DFT pur operon repressor D5R78_RS12430 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D5R78_RS12435 ENOG4105W42 Veg protein D5R78_RS12440 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D5R78_RS12445 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) D5R78_RS12450 ENOG4105F8V Hydrolase, tatD family D5R78_RS12455 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D5R78_RS12460 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D5R78_RS12465 ENOG4105VC4 domain protein D5R78_RS12470 ENOG41060K3 Methyltransferase D5R78_RS12475 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) D5R78_RS12480 ENOG4105MA4 psp1 domain protein D5R78_RS12485 ENOG4105FA2 dna polymerase iii D5R78_RS12490 ENOG4105X0R protein from nitrogen regulatory protein P-II D5R78_RS12495 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D5R78_RS12500 ENOG4105CXN decarboxylase D5R78_RS12525 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D5R78_RS12535 ENOG4105C6E dna polymerase iii D5R78_RS12550 ENOG4107414 GntR family transcriptional regulator D5R78_RS12555 ENOG4105CG3 alpha amylase, catalytic region D5R78_RS12560 ENOG4105C5Y PTS System D5R78_RS12570 ENOG4105BZ8 glutamate synthase D5R78_RS12575 ENOG4105CBC glutamate synthase D5R78_RS12610 ENOG41068JE domain protein D5R78_RS12615 ENOG4105C28 cystathionine D5R78_RS12635 ENOG4105C8J )-transporter D5R78_RS12660 ENOG410841Q phosphoesterase PA-phosphatase related protein D5R78_RS12670 ENOG4105GPN Uncharacterized conserved protein (DUF2294) D5R78_RS12675 ENOG4105EVH UPF0753 protein D5R78_RS12680 ENOG4108TWJ NADH dehydrogenase subunit 5 D5R78_RS12690 ENOG4105KA3 membrAne D5R78_RS12700 ENOG4105K5X acetyltransferase D5R78_RS12705 ENOG4105CZN Potassium uptake protein D5R78_RS12715 ENOG4108TFU terminase (Small subunit) D5R78_RS12750 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D5R78_RS12755 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D5R78_RS12760 ENOG4105C2W permease D5R78_RS12765 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) D5R78_RS12785 ENOG4107R6U sodium dicarboxylate symporter D5R78_RS12790 ENOG4108DBC nitroreductase D5R78_RS12800 ENOG4105D3R alkyl hydroperoxide reductase D5R78_RS12805 ENOG4108JU3 Alkyl hydroperoxide reductase D5R78_RS12815 ENOG4108TGR phosphatase D5R78_RS12820 ENOG4105N14 lysine exporter protein LysE YggA D5R78_RS12905 ENOG4105C26 Dehydrogenase D5R78_RS12915 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D5R78_RS12925 ENOG4108BUD transposase D5R78_RS12935 ENOG4105D29 Helix-turn-helix type 11 domain protein D5R78_RS12950 ENOG4108U7W acetyltransferase D5R78_RS12970 ENOG4108BUD transposase D5R78_RS12985 ENOG4108BUD transposase D5R78_RS12995 ENOG4108BUD transposase D5R78_RS13000 ENOG4105CJ1 ABC, transporter D5R78_RS13055 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D5R78_RS13060 ENOG4108UUM single-stranded DNA-binding protein D5R78_RS13065 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D5R78_RS13080 ENOG4105C3G gtp-binding protein D5R78_RS13085 ENOG4105VDK protein, conserved in bacteria D5R78_RS13090 ENOG4105D8X mechanosensitive ion channel D5R78_RS13095 ENOG4105FA0 parb-like partition protein D5R78_RS13100 ENOG4105C28 cystathionine D5R78_RS13105 ENOG4105C28 cystathionine D5R78_RS13115 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D5R78_RS13130 ENOG4105C5H ABC transporter D5R78_RS13140 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase D5R78_RS13160 ENOG4105C3F Signal peptidase i D5R78_RS13170 ENOG4105C19 ABC transporter D5R78_RS13215 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D5R78_RS13220 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D5R78_RS13225 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D5R78_RS13230 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)