locus-tag	class	description
GA597_RS00030	COG2353	YceI-like domain
GA597_RS00035	COG3443	Belongs to the bacterial solute-binding protein 9 family
GA597_RS00035	COG0803	Belongs to the bacterial solute-binding protein 9 family
GA597_RS00055	COG1126	abc transporter atp-binding protein
GA597_RS00060	COG0765	amino acid transport
GA597_RS00065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GA597_RS00070	COG2814	Major facilitator Superfamily
GA597_RS00080	COG0588	phosphoglycerate mutase activity
GA597_RS00085	COG0741	lytic transglycosylase activity
GA597_RS00090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GA597_RS00105	COG1929	Belongs to the glycerate kinase type-1 family
GA597_RS00115	COG2814	Major facilitator Superfamily
GA597_RS00120	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GA597_RS00125	COG2226	methyltransferase
GA597_RS00145	COG1113	amino acid transport
GA597_RS00150	COG0025	NhaP-type Na H and K H
GA597_RS00155	COG0531	amino acid
GA597_RS00165	COG0706	membrane insertase activity
GA597_RS00175	COG3477	response to acidic pH
GA597_RS00180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GA597_RS00190	COG3275	phosphorelay sensor kinase activity
GA597_RS00195	COG3279	Response regulator of the LytR AlgR family
GA597_RS00200	COG1380	Effector of murein hydrolase LrgA
GA597_RS00205	COG1346	cytolysis
GA597_RS00210	COG1174	glycine betaine transport
GA597_RS00230	COG1063	alcohol dehydrogenase
GA597_RS00235	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GA597_RS00240	COG0531	amino acid
GA597_RS00245	COG2272	Belongs to the type-B carboxylesterase lipase family
GA597_RS00250	COG2814	Major facilitator Superfamily
GA597_RS00260	COG0745	RESPONSE REGULATOR receiver
GA597_RS00265	COG2205	protein histidine kinase activity
GA597_RS00270	COG0390	transport system, permease component
GA597_RS00275	COG4619	ABC transporter
GA597_RS00290	COG0069	glutamate synthase activity
GA597_RS00305	COG1363	Peptidase, m42
GA597_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
GA597_RS00315	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GA597_RS00325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GA597_RS00330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GA597_RS00335	COG4221	oxidoreductase activity
GA597_RS00365	COG0494	nUDIX hydrolase
GA597_RS00370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GA597_RS00380	COG2610	gluconate transmembrane transporter activity
GA597_RS00385	COG1070	Carbohydrate kinase
GA597_RS00390	COG1802	Transcriptional regulator
GA597_RS00405	COG2357	RelA SpoT domain protein
GA597_RS00410	COG4876	unkown
GA597_RS00425	COG2271	Major facilitator Superfamily
GA597_RS00435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GA597_RS00440	COG2022	thiamine diphosphate biosynthetic process
GA597_RS00440	COG2104	thiamine diphosphate biosynthetic process
GA597_RS00445	COG2022	thiamine diphosphate biosynthetic process
GA597_RS00455	COG0586	Pfam SNARE associated Golgi protein
GA597_RS00460	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GA597_RS00470	COG3949	Membrane
GA597_RS00475	COG0400	carboxylic ester hydrolase activity
GA597_RS00480	COG0346	lactoylglutathione lyase activity
GA597_RS00485	COG0346	lactoylglutathione lyase activity
GA597_RS00490	COG1846	Transcriptional regulator
GA597_RS00495	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS00510	COG2514	catechol 2,3-dioxygenase activity
GA597_RS00520	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS00525	COG0778	Nitroreductase
GA597_RS00540	COG3764	Sortase (surface protein transpeptidase)
GA597_RS00555	COG1760	l-serine dehydratase
GA597_RS00560	COG1760	l-serine dehydratase
GA597_RS00570	COG1070	Carbohydrate kinase
GA597_RS00590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GA597_RS00600	COG1917	Cupin 2, conserved barrel domain protein
GA597_RS00600	COG2207	Transcriptional regulator
GA597_RS00610	COG0697	spore germination
GA597_RS00620	COG0039	L-malate dehydrogenase activity
GA597_RS00635	COG1063	alcohol dehydrogenase
GA597_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS00640	COG2190	(PTS) system
GA597_RS00640	COG1263	PTS System
GA597_RS00650	COG0028	Belongs to the TPP enzyme family
GA597_RS00655	COG1346	cytolysis
GA597_RS00660	COG1380	Effector of murein hydrolase LrgA
GA597_RS00665	COG0583	DNA-binding transcription factor activity
GA597_RS00675	COG1388	LysM domain
GA597_RS00675	COG3942	CHAP domain
GA597_RS00690	COG3425	synthase
GA597_RS00695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GA597_RS00705	COG0598	Magnesium transport protein CorA
GA597_RS00725	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS00730	COG0110	maltose O-acetyltransferase activity
GA597_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
GA597_RS00745	COG2217	Heavy metal translocating P-type atpase
GA597_RS00750	COG2608	mercury ion transmembrane transporter activity
GA597_RS00760	COG0436	Aminotransferase
GA597_RS00765	COG1233	COG1233 Phytoene dehydrogenase and related
GA597_RS00770	COG1562	ergosterol biosynthetic process
GA597_RS00775	COG0463	Glycosyl transferase, family 2
GA597_RS00780	COG1233	COG1233 Phytoene dehydrogenase and related
GA597_RS00790	COG0741	lytic transglycosylase activity
GA597_RS00815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA597_RS00850	COG3001	Fructosamine kinase
GA597_RS00855	COG0167	dihydroorotate dehydrogenase activity
GA597_RS00865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GA597_RS00900	COG3527	Alpha-acetolactate decarboxylase
GA597_RS00905	COG0028	Belongs to the TPP enzyme family
GA597_RS00910	COG0531	amino acid
GA597_RS00920	COG1464	Belongs to the NlpA lipoprotein family
GA597_RS00945	COG0563	adenylate kinase activity
GA597_RS00950	COG3588	fructose-bisphosphate aldolase
GA597_RS00970	COG2723	6-phospho-beta-galactosidase activity
GA597_RS00980	COG0579	oxidoreductase
GA597_RS00985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GA597_RS00990	COG0574	Belongs to the PEP-utilizing enzyme family
GA597_RS00990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GA597_RS01000	COG0583	DNA-binding transcription factor activity
GA597_RS01010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA597_RS01025	COG1473	amidohydrolase
GA597_RS01035	COG1473	amidohydrolase
GA597_RS01045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GA597_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS01055	COG1510	regulation of RNA biosynthetic process
GA597_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA597_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GA597_RS01080	COG2851	Citrate transporter
GA597_RS01085	COG0529	Catalyzes the synthesis of activated sulfate
GA597_RS01090	COG2046	Belongs to the sulfate adenylyltransferase family
GA597_RS01095	COG0730	response to heat
GA597_RS01110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GA597_RS01115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GA597_RS01120	COG0175	sulfate reduction
GA597_RS01155	COG1136	(ABC) transporter
GA597_RS01160	COG2205	protein histidine kinase activity
GA597_RS01165	COG0745	RESPONSE REGULATOR receiver
GA597_RS01175	COG1785	Belongs to the alkaline phosphatase family
GA597_RS01245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GA597_RS01295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GA597_RS01305	COG3961	Belongs to the TPP enzyme family
GA597_RS01310	COG2843	Capsule synthesis protein
GA597_RS01315	COG5658	integral membrane protein
GA597_RS01340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GA597_RS01350	COG2235	arginine
GA597_RS01385	COG3942	CHAP domain
GA597_RS01385	COG1705	Flagellar rod assembly protein muramidase FlgJ
GA597_RS01385	COG1705	Flagellar rod assembly protein muramidase FlgJ
GA597_RS01385	COG3942	CHAP domain
GA597_RS01390	COG2190	(PTS) system
GA597_RS01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS01390	COG1263	PTS System
GA597_RS01395	COG1288	antiporter activity
GA597_RS01410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GA597_RS01415	COG0583	DNA-binding transcription factor activity
GA597_RS01420	COG2409	Drug exporters of the RND superfamily
GA597_RS01425	COG2113	Glycine betaine
GA597_RS01435	COG2814	Major facilitator Superfamily
GA597_RS01455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GA597_RS01475	COG0745	RESPONSE REGULATOR receiver
GA597_RS01480	COG0642	Histidine kinase
GA597_RS01495	COG0653	protein targeting
GA597_RS01505	COG1073	alpha beta
GA597_RS01515	COG0201	protein transport
GA597_RS01555	COG3639	organic phosphonate transmembrane transporter activity
GA597_RS01560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GA597_RS01570	COG0737	Belongs to the 5'-nucleotidase family
GA597_RS01580	COG2814	Major facilitator Superfamily
GA597_RS01585	COG0697	spore germination
GA597_RS01590	COG1959	2 iron, 2 sulfur cluster binding
GA597_RS01595	COG1476	TRANSCRIPTIONal
GA597_RS01605	COG1131	(ABC) transporter
GA597_RS01625	COG4716	Myosin-crossreactive antigen
GA597_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA597_RS01650	COG3386	PFAM SMP-30 Gluconolaconase
GA597_RS01655	COG1054	Belongs to the UPF0176 family
GA597_RS01665	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GA597_RS01685	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GA597_RS01690	COG0747	negative chemotaxis
GA597_RS01705	COG0444	Belongs to the ABC transporter superfamily
GA597_RS01710	COG1124	(ABC) transporter
GA597_RS01745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA597_RS01750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GA597_RS01765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GA597_RS01770	COG0363	glucosamine-6-phosphate deaminase activity
GA597_RS01780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GA597_RS01795	COG4336	lyase activity
GA597_RS01800	COG5505	Protein of unknown function (DUF819)
GA597_RS01805	COG0471	metal ion transport
GA597_RS01815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GA597_RS01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA597_RS01855	COG3093	addiction module antidote protein HigA
GA597_RS01865	COG0549	Belongs to the carbamate kinase family
GA597_RS01870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GA597_RS01880	COG2314	TM2 domain
GA597_RS01900	COG0789	Transcriptional regulator
GA597_RS01950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GA597_RS01960	COG2962	Rard protein
GA597_RS01965	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GA597_RS01980	COG1695	Transcriptional regulator
GA597_RS01985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA597_RS01990	COG0508	dehydrogenase complex catalyzes the overall conversion of
GA597_RS01995	COG0022	dehydrogenase e1 component
GA597_RS02000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GA597_RS02005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA597_RS02015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GA597_RS02030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA597_RS02035	COG1846	Transcriptional regulator
GA597_RS02040	COG1063	alcohol dehydrogenase
GA597_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
GA597_RS02090	COG2318	DinB family
GA597_RS02105	COG1288	antiporter activity
GA597_RS02110	COG2249	NAD(P)H dehydrogenase (quinone) activity
GA597_RS02115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GA597_RS02125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GA597_RS02135	COG3152	Membrane
GA597_RS02145	COG2971	BadF BadG BcrA BcrD
GA597_RS02160	COG1447	Phosphotransferase system cellobiose-specific component IIA
GA597_RS02165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GA597_RS02170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GA597_RS02175	COG1737	Transcriptional regulator
GA597_RS02180	COG1876	peptidase activity
GA597_RS02190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GA597_RS02195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GA597_RS02200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GA597_RS02210	COG1879	ABC-type sugar transport system periplasmic component
GA597_RS02215	COG1172	Belongs to the binding-protein-dependent transport system permease family
GA597_RS02220	COG1129	ABC transporter
GA597_RS02225	COG1869	D-ribose catabolic process
GA597_RS02230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GA597_RS02235	COG1609	Transcriptional regulator
GA597_RS02285	COG1113	amino acid transport
GA597_RS02310	COG2910	NAD(P)H-binding
GA597_RS02315	COG1959	2 iron, 2 sulfur cluster binding
GA597_RS02320	COG1253	flavin adenine dinucleotide binding
GA597_RS02330	COG0789	Transcriptional regulator
GA597_RS02360	COG4172	Belongs to the ABC transporter superfamily
GA597_RS02365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GA597_RS02375	COG0747	negative chemotaxis
GA597_RS02385	COG1114	Component of the transport system for branched-chain amino acids
GA597_RS02390	COG0523	cobalamin synthesis protein
GA597_RS02395	COG1121	(ABC) transporter
GA597_RS02400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GA597_RS02405	COG0803	Belongs to the bacterial solute-binding protein 9 family
GA597_RS02415	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GA597_RS02440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GA597_RS02470	COG0803	Belongs to the bacterial solute-binding protein 9 family
GA597_RS02475	COG0523	cobalamin synthesis protein
GA597_RS02490	COG0668	transmembrane transport
GA597_RS02505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GA597_RS02510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA597_RS02530	COG2130	NADP-dependent
GA597_RS02535	COG0702	epimerase
GA597_RS02545	COG0789	Transcriptional regulator
GA597_RS02570	COG1388	LysM domain
GA597_RS02575	COG2217	Heavy metal translocating P-type atpase
GA597_RS02585	COG3425	synthase
GA597_RS02595	COG0584	glycerophosphoryl diester phosphodiesterase
GA597_RS02600	COG2030	dehydratase
GA597_RS02625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA597_RS02630	COG0640	Transcriptional regulator
GA597_RS02680	COG1105	Belongs to the carbohydrate kinase PfkB family
GA597_RS02690	COG1397	ADP-ribosylglycohydrolase
GA597_RS02780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA597_RS02785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA597_RS02790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA597_RS02795	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA597_RS02800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GA597_RS02955	COG0488	(ABC) transporter
GA597_RS03135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GA597_RS03140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GA597_RS03150	COG4863	YycH protein
GA597_RS03155	COG5002	protein histidine kinase activity
GA597_RS03160	COG0745	RESPONSE REGULATOR receiver
GA597_RS03175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GA597_RS03180	COG0305	Participates in initiation and elongation during chromosome replication
GA597_RS03185	COG0359	binds to the 23S rRNA
GA597_RS03190	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GA597_RS03200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GA597_RS03210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GA597_RS03215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GA597_RS03220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GA597_RS03225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GA597_RS03230	COG0187	DNA topoisomerase II activity
GA597_RS03235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GA597_RS03240	COG2501	S4 domain
GA597_RS03245	COG0592	DNA-directed DNA polymerase activity
GA597_RS03250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GA597_RS03260	COG0594	ribonuclease P activity
GA597_RS03265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GA597_RS03270	COG0445	tRNA wobble uridine modification
GA597_RS03275	COG0357	Ribosomal RNA small subunit methyltransferase G
GA597_RS03315	COG0577	efflux transmembrane transporter activity
GA597_RS03320	COG1136	(ABC) transporter
GA597_RS03345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GA597_RS03350	COG0346	lactoylglutathione lyase activity
GA597_RS03360	COG0488	(ABC) transporter
GA597_RS03375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GA597_RS03380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GA597_RS03380	COG0646	methionine synthase
GA597_RS03385	COG0626	cystathionine gamma-synthase activity
GA597_RS03390	COG0626	cystathionine gamma-synthase activity
GA597_RS03395	COG1475	DNA binding
GA597_RS03400	COG0668	transmembrane transport
GA597_RS03405	COG4481	Protein conserved in bacteria
GA597_RS03410	COG0012	GTP binding
GA597_RS03425	COG0360	Binds together with S18 to 16S ribosomal RNA
GA597_RS03435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GA597_RS03490	COG1131	(ABC) transporter
GA597_RS03545	COG0456	acetyltransferase
GA597_RS03585	COG1902	pentaerythritol trinitrate reductase activity
GA597_RS03595	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS03605	COG3682	Transcriptional regulator
GA597_RS03695	COG1280	lysine exporter protein (LysE YggA)
GA597_RS03700	COG0406	alpha-ribazole phosphatase activity
GA597_RS03710	COG3634	alkyl hydroperoxide reductase activity
GA597_RS03715	COG0450	alkyl hydroperoxide reductase
GA597_RS03725	COG0778	Nitroreductase
GA597_RS03730	COG1823	symporter activity
GA597_RS03750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GA597_RS03755	COG2233	PERMEase
GA597_RS03760	COG0517	IMP dehydrogenase activity
GA597_RS03760	COG0516	GMP reductase activity
GA597_RS03765	COG0519	Catalyzes the synthesis of GMP from XMP
GA597_RS03765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GA597_RS03805	COG3728	DNA packaging
GA597_RS03805	COG5484	DNA packaging
GA597_RS03815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GA597_RS03830	COG3759	membrane
GA597_RS03840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA597_RS03845	COG3002	Belongs to the UPF0753 family
GA597_RS03850	COG5609	conserved protein (DUF2294)
GA597_RS03860	COG0671	phosphoesterase, PA-phosphatase related
GA597_RS03870	COG1647	Serine aminopeptidase, S33
GA597_RS03885	COG0733	neurotransmitter:sodium symporter activity
GA597_RS03900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GA597_RS03905	COG0626	cystathionine gamma-synthase activity
GA597_RS03910	COG1388	LysM domain
GA597_RS03910	COG3942	CHAP domain
GA597_RS03945	COG0070	glutamate synthase
GA597_RS03945	COG0069	glutamate synthase activity
GA597_RS03945	COG0067	glutamate synthase
GA597_RS03950	COG0493	'glutamate synthase
GA597_RS03960	COG1263	PTS System
GA597_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS03965	COG0366	Alpha amylase catalytic
GA597_RS03970	COG2188	Transcriptional regulator
GA597_RS03985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GA597_RS03995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GA597_RS04020	COG1982	Orn Lys Arg decarboxylase major
GA597_RS04025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GA597_RS04030	COG3870	Protein conserved in bacteria
GA597_RS04035	COG0470	DNA polymerase III
GA597_RS04040	COG1774	PSP1 C-terminal conserved region
GA597_RS04045	COG4467	Involved in initiation control of chromosome replication
GA597_RS04050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GA597_RS04055	COG2827	Endonuclease containing a URI domain
GA597_RS04060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GA597_RS04065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA597_RS04065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA597_RS04070	COG0084	hydrolase, TatD family'
GA597_RS04075	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GA597_RS04080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GA597_RS04085	COG4466	Protein conserved in bacteria
GA597_RS04090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GA597_RS04095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GA597_RS04100	COG0251	oxidation-reduction process
GA597_RS04105	COG2088	sporulation resulting in formation of a cellular spore
GA597_RS04110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GA597_RS04115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GA597_RS04120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GA597_RS04125	COG0193	aminoacyl-tRNA hydrolase activity
GA597_RS04130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GA597_RS04135	COG2244	polysaccharide biosynthetic process
GA597_RS04140	COG3956	TIGRFAM MazG family protein
GA597_RS04145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GA597_RS04155	COG1098	S1 RNA binding domain
GA597_RS04160	COG0037	tRNA processing
GA597_RS04170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GA597_RS04175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GA597_RS04180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GA597_RS04195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GA597_RS04200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GA597_RS04285	COG2259	Doxx family
GA597_RS04290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GA597_RS04295	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GA597_RS04300	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GA597_RS04305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GA597_RS04310	COG4463	regulation of RNA biosynthetic process
GA597_RS04315	COG3880	PFAM UvrB UvrC protein
GA597_RS04320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GA597_RS04325	COG0542	response to heat
GA597_RS04330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GA597_RS04335	COG4956	integral membrane protein (PIN domain superfamily)
GA597_RS04340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GA597_RS04345	COG1045	serine acetyltransferase
GA597_RS04350	COG0215	cysteine-tRNA ligase activity
GA597_RS04355	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GA597_RS04360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA597_RS04365	COG3688	RNA-binding protein containing a PIN domain
GA597_RS04375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GA597_RS04380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GA597_RS04385	COG0250	Participates in transcription elongation, termination and antitermination
GA597_RS04390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GA597_RS04395	COG0081	regulation of translation
GA597_RS04405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GA597_RS04410	COG0222	ribosome binding
GA597_RS04415	COG2813	Specifically methylates the guanine in position
GA597_RS04420	COG0085	RNA polymerase activity
GA597_RS04425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GA597_RS04435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GA597_RS04445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GA597_RS04450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GA597_RS04460	COG1473	amidohydrolase
GA597_RS04485	COG0737	Belongs to the 5'-nucleotidase family
GA597_RS04490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GA597_RS04495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GA597_RS04535	COG0546	phosphoglycolate phosphatase activity
GA597_RS04540	COG1428	Deoxynucleoside kinase
GA597_RS04545	COG1428	Deoxynucleoside kinase
GA597_RS04555	COG0561	phosphatase activity
GA597_RS04560	COG0431	NADPH-dependent FMN reductase
GA597_RS04600	COG1469	GTP cyclohydrolase I activity
GA597_RS04605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GA597_RS04615	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GA597_RS04620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GA597_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
GA597_RS04680	COG0183	Belongs to the thiolase family
GA597_RS04695	COG0477	Major facilitator Superfamily
GA597_RS04710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GA597_RS04720	COG2363	Small membrane protein
GA597_RS04735	COG2966	Psort location CytoplasmicMembrane, score
GA597_RS04740	COG3253	May function as heme-dependent peroxidase
GA597_RS04750	COG0095	Lipoate-protein ligase
GA597_RS04775	COG4844	belongs to the
GA597_RS04780	COG1278	Cold shock
GA597_RS04785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA597_RS04795	COG0667	Aldo Keto reductase
GA597_RS04800	COG0655	NAD(P)H dehydrogenase (quinone) activity
GA597_RS04810	COG1078	dGTPase activity
GA597_RS04900	COG0018	arginyl-trna synthetase
GA597_RS04905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GA597_RS04920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GA597_RS04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS04985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA597_RS04985	COG2111	Na H antiporter
GA597_RS04990	COG2111	Na H antiporter
GA597_RS04995	COG1006	Multisubunit Na H antiporter MnhC subunit
GA597_RS05000	COG0651	ATP synthesis coupled electron transport
GA597_RS05005	COG1863	multisubunit Na H antiporter MnhE subunit
GA597_RS05010	COG2212	antiporter activity
GA597_RS05015	COG1320	monovalent cation:proton antiporter activity
GA597_RS05040	COG1321	iron dependent repressor
GA597_RS05050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GA597_RS05055	COG1134	teichoic acid transport
GA597_RS05060	COG1682	transport, permease protein
GA597_RS05065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GA597_RS05075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GA597_RS05080	COG1686	Belongs to the peptidase S11 family
GA597_RS05090	COG1132	(ABC) transporter
GA597_RS05100	COG0463	Glycosyl transferase, family 2
GA597_RS05100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GA597_RS05105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GA597_RS05110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GA597_RS05115	COG1120	ATPase activity
GA597_RS05120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS05125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS05130	COG2376	Dihydroxyacetone kinase
GA597_RS05140	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GA597_RS05150	COG3949	Membrane
GA597_RS05155	COG0657	acetylesterase activity
GA597_RS05165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GA597_RS05170	COG0745	RESPONSE REGULATOR receiver
GA597_RS05175	COG2205	protein histidine kinase activity
GA597_RS05180	COG1136	(ABC) transporter
GA597_RS05185	COG0577	efflux transmembrane transporter activity
GA597_RS05190	COG1392	Phosphate transport regulator
GA597_RS05195	COG0306	phosphate transporter
GA597_RS05200	COG3942	CHAP domain
GA597_RS05200	COG1388	LysM domain
GA597_RS05220	COG0217	transcriptional regulatory protein
GA597_RS05230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GA597_RS05240	COG0583	DNA-binding transcription factor activity
GA597_RS05250	COG2839	Protein conserved in bacteria
GA597_RS05260	COG0456	acetyltransferase
GA597_RS05275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GA597_RS05280	COG1611	Belongs to the LOG family
GA597_RS05285	COG1671	Belongs to the UPF0178 family
GA597_RS05295	COG1968	undecaprenyl-diphosphatase activity
GA597_RS05300	COG4988	ABC transporter
GA597_RS05305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GA597_RS05315	COG0523	cobalamin synthesis protein
GA597_RS05325	COG0471	metal ion transport
GA597_RS05330	COG0415	Belongs to the DNA photolyase family
GA597_RS05360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GA597_RS05365	COG1349	DNA-binding transcription factor activity
GA597_RS05370	COG1105	Belongs to the carbohydrate kinase PfkB family
GA597_RS05375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GA597_RS05375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GA597_RS05375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GA597_RS05380	COG1253	flavin adenine dinucleotide binding
GA597_RS05385	COG0656	L-ascorbic acid biosynthetic process
GA597_RS05395	COG0463	Glycosyl transferase, family 2
GA597_RS05405	COG0602	queuosine metabolic process
GA597_RS05410	COG0720	synthase
GA597_RS05415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GA597_RS05420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GA597_RS05420	COG0512	Glutamine amidotransferase of anthranilate synthase
GA597_RS05440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GA597_RS05445	COG1984	allophanate hydrolase subunit 2
GA597_RS05450	COG1368	sulfuric ester hydrolase activity
GA597_RS05465	COG0488	(ABC) transporter
GA597_RS05470	COG0514	ATP-dependent DNA helicase (RecQ)
GA597_RS05480	COG1174	glycine betaine transport
GA597_RS05485	COG3104	oligopeptide transport
GA597_RS05490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GA597_RS05500	COG1597	lipid kinase activity
GA597_RS05505	COG3104	oligopeptide transport
GA597_RS05510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GA597_RS05520	COG1780	Probably involved in ribonucleotide reductase function
GA597_RS05525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GA597_RS05530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GA597_RS05535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS05540	COG4605	iron ion homeostasis
GA597_RS05545	COG4604	ABC transporter, ATP-binding protein
GA597_RS05550	COG4607	ABC-type enterochelin transport system periplasmic component
GA597_RS05565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GA597_RS05585	COG1929	Belongs to the glycerate kinase type-1 family
GA597_RS05590	COG2195	Cleaves the N-terminal amino acid of tripeptides
GA597_RS05605	COG2199	diguanylate cyclase activity
GA597_RS05610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GA597_RS05615	COG1739	Uncharacterized protein family UPF0029
GA597_RS05625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GA597_RS05630	COG1040	competence protein
GA597_RS05635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GA597_RS05640	COG0653	protein targeting
GA597_RS05650	COG3942	CHAP domain
GA597_RS05650	COG1388	LysM domain
GA597_RS05655	COG0300	oxidoreductase activity
GA597_RS05670	COG0556	nucleotide-excision repair
GA597_RS05675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GA597_RS05680	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GA597_RS05685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GA597_RS05700	COG0492	ferredoxin-NADP+ reductase activity
GA597_RS05705	COG1660	Displays ATPase and GTPase activities
GA597_RS05710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GA597_RS05715	COG1481	regulation of sporulation
GA597_RS05720	COG0740	serine-type endopeptidase activity
GA597_RS05730	COG1090	epimerase
GA597_RS05750	COG2390	Transcriptional regulator
GA597_RS05760	COG0126	phosphoglycerate kinase activity
GA597_RS05765	COG0149	triose-phosphate isomerase activity
GA597_RS05770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GA597_RS05775	COG0148	phosphopyruvate hydratase activity
GA597_RS05785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GA597_RS05790	COG1647	Serine aminopeptidase, S33
GA597_RS05795	COG0557	exoribonuclease II activity
GA597_RS05800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GA597_RS05890	COG0305	Participates in initiation and elongation during chromosome replication
GA597_RS05955	COG0756	dUTP diphosphatase activity
GA597_RS06075	COG1196	nuclear chromosome segregation
GA597_RS06075	COG0741	lytic transglycosylase activity
GA597_RS06075	COG0739	heme binding
GA597_RS06230	COG5484	DNA packaging
GA597_RS06230	COG3728	DNA packaging
GA597_RS06285	COG4195	phage-related replication protein
GA597_RS06290	COG0456	acetyltransferase
GA597_RS06330	COG0406	alpha-ribazole phosphatase activity
GA597_RS06335	COG1279	arginine transmembrane transporter activity
GA597_RS06345	COG1764	response to oxidative stress
GA597_RS06350	COG0710	3-dehydroquinate dehydratase activity
GA597_RS06360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GA597_RS06365	COG1393	Belongs to the ArsC family
GA597_RS06370	COG0509	glycine decarboxylation via glycine cleavage system
GA597_RS06375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GA597_RS06385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GA597_RS06390	COG2011	ABC-type metal ion transport system permease component
GA597_RS06395	COG1464	Belongs to the NlpA lipoprotein family
GA597_RS06400	COG3237	CsbD-like
GA597_RS06415	COG0396	ATPase activity
GA597_RS06420	COG0719	Fe-S assembly protein
GA597_RS06430	COG0822	iron-sulfur transferase activity
GA597_RS06435	COG0719	Fe-S assembly protein
GA597_RS06445	COG2070	2-Nitropropane dioxygenase
GA597_RS06450	COG1801	Protein of unknown function DUF72
GA597_RS06455	COG0730	response to heat
GA597_RS06460	COG0737	Belongs to the 5'-nucleotidase family
GA597_RS06465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GA597_RS06470	COG4470	Protein conserved in bacteria
GA597_RS06480	COG2445	Protein of unknown function DUF86
GA597_RS06485	COG0647	UMP catabolic process
GA597_RS06500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GA597_RS06505	COG1696	Membrane protein involved in D-alanine export
GA597_RS06510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GA597_RS06515	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GA597_RS06525	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GA597_RS06530	COG4837	Protein of unknown function (DUF1462)
GA597_RS06535	COG1252	NADH dehydrogenase
GA597_RS06540	COG4844	belongs to the
GA597_RS06545	COG0316	Belongs to the HesB IscA family
GA597_RS06550	COG1252	NADH dehydrogenase
GA597_RS06555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GA597_RS06560	COG2056	Na+-H+ antiporter family
GA597_RS06565	COG2050	protein possibly involved in aromatic compounds catabolism
GA597_RS06575	COG1320	monovalent cation:proton antiporter activity
GA597_RS06580	COG2212	antiporter activity
GA597_RS06585	COG1863	multisubunit Na H antiporter MnhE subunit
GA597_RS06590	COG0651	ATP synthesis coupled electron transport
GA597_RS06595	COG1006	Multisubunit Na H antiporter MnhC subunit
GA597_RS06600	COG2111	Na H antiporter
GA597_RS06605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GA597_RS06605	COG2111	Na H antiporter
GA597_RS06615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GA597_RS06620	COG1098	S1 RNA binding domain
GA597_RS06625	COG1902	pentaerythritol trinitrate reductase activity
GA597_RS06640	COG0584	glycerophosphoryl diester phosphodiesterase
GA597_RS06645	COG0165	Argininosuccinate lyase
GA597_RS06650	COG0137	argininosuccinate synthase activity
GA597_RS06655	COG0166	Belongs to the GPI family
GA597_RS06660	COG0398	Pfam SNARE associated Golgi protein
GA597_RS06675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GA597_RS06680	COG1074	ATP-dependent DNA helicase activity
GA597_RS06685	COG0179	Fumarylacetoacetate (FAA) hydrolase
GA597_RS06695	COG0446	pyridine nucleotide-disulphide oxidoreductase
GA597_RS06700	COG0561	phosphatase activity
GA597_RS06715	COG0542	response to heat
GA597_RS06725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GA597_RS06740	COG0601	transmembrane transport
GA597_RS06745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GA597_RS06750	COG0444	Belongs to the ABC transporter superfamily
GA597_RS06755	COG4608	Belongs to the ABC transporter superfamily
GA597_RS06760	COG4166	transmembrane transport
GA597_RS06775	COG0180	Tryptophanyl-tRNA synthetase
GA597_RS06780	COG1393	Belongs to the ArsC family
GA597_RS06785	COG4862	establishment of competence for transformation
GA597_RS06795	COG1164	Oligoendopeptidase f
GA597_RS06800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GA597_RS06805	COG2346	COG2346, Truncated hemoglobins
GA597_RS06810	COG4116	CYTH
GA597_RS06820	COG2357	RelA SpoT domain protein
GA597_RS06825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GA597_RS06830	COG0564	pseudouridine synthase activity
GA597_RS06835	COG2239	Acts as a magnesium transporter
GA597_RS06840	COG0475	glutathione-regulated potassium exporter activity
GA597_RS06840	COG0569	domain protein
GA597_RS06850	COG0628	permease
GA597_RS06855	COG2382	esterase
GA597_RS06860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GA597_RS06865	COG2814	Major facilitator Superfamily
GA597_RS06870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GA597_RS06885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GA597_RS06895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GA597_RS06900	COG0861	Integral membrane protein TerC family
GA597_RS06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GA597_RS06910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GA597_RS06930	COG4873	Protein conserved in bacteria
GA597_RS06990	COG1575	Belongs to the MenA family. Type 1 subfamily
GA597_RS06995	COG1169	isochorismate synthase
GA597_RS07000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GA597_RS07005	COG0596	Alpha beta hydrolase
GA597_RS07010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GA597_RS07015	COG0436	Aminotransferase
GA597_RS07020	COG3594	Acyltransferase
GA597_RS07050	COG1316	TRANSCRIPTIONal
GA597_RS07055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GA597_RS07065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GA597_RS07070	COG1845	cytochrome c oxidase, subunit III
GA597_RS07075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GA597_RS07080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GA597_RS07105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GA597_RS07110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GA597_RS07115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GA597_RS07120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GA597_RS07125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GA597_RS07130	COG0047	phosphoribosylformylglycinamidine synthase activity
GA597_RS07135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GA597_RS07145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GA597_RS07155	COG0138	bifunctional purine biosynthesis protein purh
GA597_RS07160	COG0151	Belongs to the GarS family
GA597_RS07165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GA597_RS07170	COG1122	ATPase activity
GA597_RS07190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GA597_RS07205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GA597_RS07225	COG1271	oxidase subunit
GA597_RS07230	COG1294	oxidase, subunit
GA597_RS07235	COG0569	domain protein
GA597_RS07240	COG2832	Protein of unknown function (DUF454)
GA597_RS07250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GA597_RS07255	COG5503	Protein of unknown function (DUF1447)
GA597_RS07260	COG0242	peptide deformylase activity
GA597_RS07290	COG4476	Belongs to the UPF0223 family
GA597_RS07295	COG1396	sequence-specific DNA binding
GA597_RS07295	COG3800	Transcriptional regulator
GA597_RS07300	COG3842	ATPase activity
GA597_RS07305	COG1176	ABC-type spermidine putrescine transport system, permease component I
GA597_RS07310	COG1177	transmembrane transport
GA597_RS07330	COG1914	H( )-stimulated, divalent metal cation uptake system
GA597_RS07335	COG4493	Belongs to the UPF0637 family
GA597_RS07340	COG0483	inositol monophosphate 1-phosphatase activity
GA597_RS07350	COG1217	gtp-binding protein TYPA
GA597_RS07355	COG4896	Protein conserved in bacteria
GA597_RS07360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GA597_RS07365	COG4838	Belongs to the UPF0358 family
GA597_RS07370	COG0772	Belongs to the SEDS family
GA597_RS07380	COG1612	heme a metabolic process
GA597_RS07385	COG0109	protoheme IX farnesyltransferase activity
GA597_RS07395	COG2340	Cysteine-rich secretory protein family
GA597_RS07400	COG3679	Belongs to the UPF0342 family
GA597_RS07410	COG4471	UPF0298 protein
GA597_RS07420	COG0742	ribosomal rna small subunit methyltransferase
GA597_RS07425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GA597_RS07430	COG1323	Belongs to the UPF0348 family
GA597_RS07445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GA597_RS07450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GA597_RS07455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GA597_RS07460	COG0072	phenylalanine-tRNA ligase activity
GA597_RS07460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA597_RS07465	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GA597_RS07470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GA597_RS07480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GA597_RS07480	COG1796	DNA polymerase
GA597_RS07485	COG1193	negative regulation of DNA recombination
GA597_RS07490	COG3118	belongs to the thioredoxin family
GA597_RS07495	COG0322	excinuclease ABC activity
GA597_RS07500	COG2009	succinate dehydrogenase
GA597_RS07505	COG1053	succinate dehydrogenase
GA597_RS07510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GA597_RS07515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GA597_RS07520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GA597_RS07560	COG1011	Hydrolase
GA597_RS07565	COG0454	-acetyltransferase
GA597_RS07570	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GA597_RS07575	COG2001	Belongs to the MraZ family
GA597_RS07580	COG0275	rRNA processing
GA597_RS07585	COG4839	cell division protein FtsL
GA597_RS07590	COG0768	penicillin binding
GA597_RS07595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GA597_RS07600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GA597_RS07605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GA597_RS07610	COG0849	cell division
GA597_RS07615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GA597_RS07620	COG1496	oxidoreductase activity
GA597_RS07625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GA597_RS07630	COG1799	cell septum assembly
GA597_RS07635	COG0762	integral membrane protein
GA597_RS07645	COG3599	regulation of cell shape
GA597_RS07650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GA597_RS07655	COG0702	epimerase
GA597_RS07665	COG1388	LysM domain
GA597_RS07665	COG3942	CHAP domain
GA597_RS07670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GA597_RS07675	COG0564	pseudouridine synthase activity
GA597_RS07680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GA597_RS07685	COG2233	PERMEase
GA597_RS07690	COG0540	Belongs to the ATCase OTCase family
GA597_RS07700	COG0505	Belongs to the CarA family
GA597_RS07705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GA597_RS07710	COG0284	orotidine-5'-phosphate decarboxylase activity
GA597_RS07715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GA597_RS07735	COG0194	GDP metabolic process
GA597_RS07740	COG1758	RNA polymerase activity
GA597_RS07745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GA597_RS07750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GA597_RS07765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GA597_RS07770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GA597_RS07770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GA597_RS07775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GA597_RS07780	COG0631	protein serine/threonine phosphatase activity
GA597_RS07790	COG1162	GTPase activity
GA597_RS07795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GA597_RS07800	COG1564	THIamine pyrophosphokinase
GA597_RS07810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GA597_RS07815	COG1302	Protein conserved in bacteria
GA597_RS07820	COG1461	Dihydroxyacetone kinase
GA597_RS07835	COG1349	DNA-binding transcription factor activity
GA597_RS07840	COG0416	fatty acid biosynthetic process
GA597_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
GA597_RS07855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GA597_RS07860	COG0571	ribonuclease III activity
GA597_RS07865	COG1196	nuclear chromosome segregation
GA597_RS07870	COG0552	protein localization to endoplasmic reticulum
GA597_RS07875	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GA597_RS07880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GA597_RS07885	COG0228	four-way junction DNA binding
GA597_RS07890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GA597_RS07895	COG0336	Belongs to the RNA methyltransferase TrmD family
GA597_RS07900	COG0335	large ribosomal subunit rRNA binding
GA597_RS07910	COG4485	Bacterial membrane protein, YfhO
GA597_RS07920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GA597_RS07925	COG0045	succinate-CoA ligase (ADP-forming) activity
GA597_RS07930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GA597_RS07940	COG0758	DNA mediated transformation
GA597_RS07950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GA597_RS07955	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GA597_RS07960	COG4974	Belongs to the 'phage' integrase family
GA597_RS07965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GA597_RS07970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GA597_RS07975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GA597_RS07980	COG0052	Belongs to the universal ribosomal protein uS2 family
GA597_RS07985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GA597_RS07990	COG0528	UMP kinase activity
GA597_RS07995	COG0233	cytoplasmic translational termination
GA597_RS08000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GA597_RS08005	COG4589	Belongs to the CDS family
GA597_RS08015	COG0442	prolyl-tRNA aminoacylation
GA597_RS08020	COG2176	DNA-directed DNA polymerase activity
GA597_RS08025	COG0779	Required for maturation of 30S ribosomal subunits
GA597_RS08030	COG0195	Participates in both transcription termination and antitermination
GA597_RS08035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GA597_RS08040	COG1358	cellular component organization or biogenesis
GA597_RS08045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GA597_RS08050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GA597_RS08055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GA597_RS08060	COG0196	riboflavin kinase activity
GA597_RS08065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GA597_RS08070	COG1185	polyribonucleotide nucleotidyltransferase activity
GA597_RS08075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GA597_RS08080	COG1674	ftsk spoiiie
GA597_RS08085	COG2188	Transcriptional regulator
GA597_RS08090	COG0612	Peptidase, M16
GA597_RS08095	COG0612	Peptidase, M16
GA597_RS08100	COG0300	oxidoreductase activity
GA597_RS08120	COG1058	Belongs to the CinA family
GA597_RS08120	COG1546	Belongs to the CinA family
GA597_RS08125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GA597_RS08135	COG0456	acetyltransferase
GA597_RS08150	COG1418	mRNA catabolic process
GA597_RS08160	COG1692	metallophosphoesterase
GA597_RS08165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GA597_RS08165	COG0674	pyruvate-flavodoxin oxidoreductase activity
GA597_RS08170	COG1013	pyruvate-flavodoxin oxidoreductase activity
GA597_RS08175	COG4195	phage-related replication protein
GA597_RS08185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GA597_RS08190	COG4550	Control of competence regulator ComK, YlbF/YmcA
GA597_RS08200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GA597_RS08205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GA597_RS08215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GA597_RS08220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GA597_RS08225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GA597_RS08235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GA597_RS08240	COG1923	regulation of RNA biosynthetic process
GA597_RS08245	COG0386	Belongs to the glutathione peroxidase family
GA597_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GA597_RS08255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GA597_RS08260	COG0789	Transcriptional regulator
GA597_RS08435	COG0740	serine-type endopeptidase activity
GA597_RS08530	COG4824	toxin secretion phage lysis holin
GA597_RS08595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA597_RS08600	COG1131	(ABC) transporter
GA597_RS08610	COG4585	Histidine kinase
GA597_RS08615	COG2197	response regulator
GA597_RS08655	COG0527	aspartate kinase activity
GA597_RS08660	COG0460	homoserine dehydrogenase
GA597_RS08665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GA597_RS08670	COG0083	homoserine kinase activity
GA597_RS08685	COG0833	amino acid
GA597_RS08690	COG0753	catalase activity
GA597_RS08700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GA597_RS08705	COG0516	GMP reductase activity
GA597_RS08710	COG2340	Cysteine-rich secretory protein family
GA597_RS08715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GA597_RS08725	COG4224	UPF0291 protein
GA597_RS08740	COG4846	Membrane protein involved in cytochrome C biogenesis
GA597_RS08745	COG0420	3'-5' exonuclease activity
GA597_RS08750	COG0419	ATPase involved in DNA repair
GA597_RS08755	COG1970	mechanosensitive ion channel activity
GA597_RS08760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA597_RS08765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GA597_RS08770	COG0824	Thioesterase
GA597_RS08775	COG4841	protein insertion into membrane
GA597_RS08780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GA597_RS08785	COG0187	DNA topoisomerase II activity
GA597_RS08790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GA597_RS08795	COG1115	amino acid carrier protein
GA597_RS08800	COG3711	transcriptional antiterminator
GA597_RS08805	COG0628	permease
GA597_RS08810	COG0392	lysyltransferase activity
GA597_RS08810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GA597_RS08825	COG1942	4-Oxalocrotonate Tautomerase
GA597_RS08830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GA597_RS08835	COG0287	Prephenate dehydrogenase
GA597_RS08840	COG1363	Peptidase, m42
GA597_RS08845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GA597_RS08850	COG0512	Glutamine amidotransferase of anthranilate synthase
GA597_RS08855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GA597_RS08860	COG0134	indole-3-glycerol-phosphate synthase activity
GA597_RS08865	COG0135	phosphoribosylanthranilate isomerase activity
GA597_RS08875	COG0159	tryptophan synthase activity
GA597_RS08885	COG2348	transferase activity, transferring amino-acyl groups
GA597_RS08890	COG2348	transferase activity, transferring amino-acyl groups
GA597_RS08895	COG0561	phosphatase activity
GA597_RS08900	COG4607	ABC-type enterochelin transport system periplasmic component
GA597_RS08910	COG1164	Oligoendopeptidase f
GA597_RS08915	COG0704	Plays a role in the regulation of phosphate uptake
GA597_RS08920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GA597_RS08925	COG0581	inorganic phosphate transmembrane transporter activity
GA597_RS08930	COG0573	inorganic phosphate transmembrane transporter activity
GA597_RS08935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GA597_RS08940	COG2996	Protein conserved in bacteria
GA597_RS08945	COG0488	(ABC) transporter
GA597_RS08955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GA597_RS08960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GA597_RS08965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GA597_RS08970	COG2171	N-acyltransferase activity
GA597_RS08975	COG1473	amidohydrolase
GA597_RS08995	COG1278	Cold shock
GA597_RS09005	COG1254	Belongs to the acylphosphatase family
GA597_RS09015	COG3853	Toxic anion resistance protein (TelA)
GA597_RS09020	COG1114	Component of the transport system for branched-chain amino acids
GA597_RS09025	COG4548	von Willebrand factor, type A
GA597_RS09030	COG0714	Associated with various cellular activities
GA597_RS09050	COG0508	dehydrogenase complex catalyzes the overall conversion of
GA597_RS09055	COG0567	Dehydrogenase, E1 component
GA597_RS09060	COG5002	protein histidine kinase activity
GA597_RS09065	COG0745	RESPONSE REGULATOR receiver
GA597_RS09070	COG0671	phosphoesterase, PA-phosphatase related
GA597_RS09075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GA597_RS09085	COG0793	Belongs to the peptidase S41A family
GA597_RS09090	COG4479	Belongs to the UPF0346 family
GA597_RS09095	COG2190	(PTS) system
GA597_RS09100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GA597_RS09120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GA597_RS09130	COG1413	lyase activity
GA597_RS09135	COG1413	lyase activity
GA597_RS09145	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GA597_RS09180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GA597_RS09185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GA597_RS09195	COG0116	Belongs to the methyltransferase superfamily
GA597_RS09205	COG3599	regulation of cell shape
GA597_RS09210	COG4474	Belongs to the UPF0398 family
GA597_RS09220	COG3331	DNA recombination
GA597_RS09225	COG4499	WXG100 protein secretion system (Wss), protein YukC
GA597_RS09225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA597_RS09235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GA597_RS09240	COG3935	DnaD domain protein
GA597_RS09245	COG0017	Asparaginyl-tRNA synthetase
GA597_RS09250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GA597_RS09250	COG1199	ATP-dependent helicase activity
GA597_RS09260	COG0617	tRNA 3'-terminal CCA addition
GA597_RS09265	COG0438	transferase activity, transferring glycosyl groups
GA597_RS09270	COG1694	Mazg nucleotide pyrophosphohydrolase
GA597_RS09275	COG2738	Putative neutral zinc metallopeptidase
GA597_RS09285	COG5582	Belongs to the UPF0302 family
GA597_RS09290	COG0457	Tetratricopeptide repeat
GA597_RS09295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GA597_RS09300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GA597_RS09305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GA597_RS09310	COG0105	UTP biosynthetic process
GA597_RS09315	COG0142	geranyltranstransferase activity
GA597_RS09320	COG2226	methyltransferase
GA597_RS09340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GA597_RS09345	COG1160	GTP binding
GA597_RS09350	COG0539	negative regulation of cytoplasmic translation
GA597_RS09355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GA597_RS09365	COG0492	ferredoxin-NADP+ reductase activity
GA597_RS09375	COG1388	LysM domain
GA597_RS09380	COG0514	ATP-dependent DNA helicase (RecQ)
GA597_RS09390	COG1141	Ferredoxin
GA597_RS09405	COG0745	RESPONSE REGULATOR receiver
GA597_RS09410	COG1187	pseudouridine synthase activity
GA597_RS09415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GA597_RS09420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GA597_RS09430	COG4974	Belongs to the 'phage' integrase family
GA597_RS09435	COG0735	belongs to the Fur family
GA597_RS09440	COG0494	nUDIX hydrolase
GA597_RS09445	COG0667	Aldo Keto reductase
GA597_RS09455	COG0300	oxidoreductase activity
GA597_RS09460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GA597_RS09465	COG1234	tRNA 3'-trailer cleavage
GA597_RS09470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GA597_RS09485	COG0366	Alpha amylase catalytic
GA597_RS09490	COG1609	Transcriptional regulator
GA597_RS09500	COG2195	Cleaves the N-terminal amino acid of tripeptides
GA597_RS09515	COG4129	membrane
GA597_RS09525	COG0508	dehydrogenase complex catalyzes the overall conversion of
GA597_RS09530	COG0022	dehydrogenase e1 component
GA597_RS09535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GA597_RS09540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GA597_RS09550	COG0497	DNA recombination
GA597_RS09555	COG1438	arginine binding
GA597_RS09565	COG1722	exodeoxyribonuclease VII activity
GA597_RS09570	COG1570	exodeoxyribonuclease VII activity
GA597_RS09575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GA597_RS09580	COG1302	Protein conserved in bacteria
GA597_RS09585	COG0439	Biotin carboxylase
GA597_RS09590	COG0511	ligase activity, forming carbon-carbon bonds
GA597_RS09595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GA597_RS09600	COG0006	proline dipeptidase activity
GA597_RS09615	COG0095	Lipoate-protein ligase
GA597_RS09620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GA597_RS09625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GA597_RS09630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GA597_RS09635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GA597_RS09640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GA597_RS09665	COG4537	Required for transformation and DNA binding
GA597_RS09670	COG1459	type II secretion system
GA597_RS09675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GA597_RS09680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA597_RS09685	COG0011	TIGRFAM Protein of
GA597_RS09690	COG1940	carbohydrate kinase activity
GA597_RS09695	COG4483	Protein conserved in bacteria
GA597_RS09705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GA597_RS09710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GA597_RS09715	COG0768	penicillin binding
GA597_RS09720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GA597_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GA597_RS09740	COG1121	(ABC) transporter
GA597_RS09745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GA597_RS09750	COG0513	Belongs to the DEAD box helicase family
GA597_RS09755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GA597_RS09760	COG2384	SAM-dependent methyltransferase
GA597_RS09765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GA597_RS09775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GA597_RS09780	COG0517	IMP dehydrogenase activity
GA597_RS09785	COG0423	glycine-tRNA ligase activity
GA597_RS09790	COG1381	Involved in DNA repair and RecF pathway recombination
GA597_RS09795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GA597_RS09805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GA597_RS09810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GA597_RS09815	COG1702	phosphate starvation-inducible protein PhoH
GA597_RS09825	COG4864	UPF0365 protein
GA597_RS09830	COG1030	water channel activity
GA597_RS09845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GA597_RS09850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GA597_RS09855	COG2264	protein methyltransferase activity
GA597_RS09860	COG0484	heat shock protein binding
GA597_RS09865	COG0443	Heat shock 70 kDa protein
GA597_RS09870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GA597_RS09875	COG1420	regulation of RNA biosynthetic process
GA597_RS09880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GA597_RS09885	COG0481	GTPase activity
GA597_RS09890	COG0268	Binds directly to 16S ribosomal RNA
GA597_RS09900	COG1466	dna polymerase III delta subunit
GA597_RS09905	COG0658	competence protein
GA597_RS09905	COG2333	competence protein COMEC
GA597_RS09910	COG2131	deaminase
GA597_RS09915	COG1555	photosystem II stabilization
GA597_RS09915	COG1596	polysaccharide export
GA597_RS09920	COG2226	methyltransferase
GA597_RS09925	COG0799	negative regulation of ribosome biogenesis
GA597_RS09930	COG1713	HD superfamily hydrolase involved in NAD metabolism
GA597_RS09935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GA597_RS09940	COG1534	Rna-binding protein
GA597_RS09945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GA597_RS09950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GA597_RS09955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GA597_RS09960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GA597_RS09965	COG1914	H( )-stimulated, divalent metal cation uptake system
GA597_RS09970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GA597_RS09975	COG0439	Biotin carboxylase
GA597_RS09980	COG0511	ligase activity, forming carbon-carbon bonds
GA597_RS09985	COG1984	allophanate hydrolase subunit 2
GA597_RS09990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GA597_RS10000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GA597_RS10005	COG0572	uridine kinase
GA597_RS10010	COG0826	peptidase U32
GA597_RS10015	COG0826	peptidase U32
GA597_RS10025	COG3906	Belongs to the UPF0473 family
GA597_RS10030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GA597_RS10035	COG4472	Bacterial protein of unknown function (DUF965)
GA597_RS10040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GA597_RS10045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GA597_RS10055	COG0482	sulfurtransferase activity
GA597_RS10060	COG1104	cysteine desulfurase activity
GA597_RS10065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA597_RS10070	COG1959	2 iron, 2 sulfur cluster binding
GA597_RS10075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GA597_RS10080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GA597_RS10090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GA597_RS10095	COG0124	histidyl-tRNA synthetase
GA597_RS10100	COG0860	N-Acetylmuramoyl-L-alanine amidase
GA597_RS10105	COG1490	D-aminoacyl-tRNA deacylase activity
GA597_RS10110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GA597_RS10115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GA597_RS10120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GA597_RS10120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GA597_RS10125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GA597_RS10125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GA597_RS10130	COG1862	Preprotein translocase
GA597_RS10135	COG0343	queuine tRNA-ribosyltransferase activity
GA597_RS10140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GA597_RS10145	COG2255	four-way junction helicase activity
GA597_RS10150	COG0632	four-way junction helicase activity
GA597_RS10155	COG4492	Belongs to the UPF0735 family
GA597_RS10160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GA597_RS10165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GA597_RS10170	COG2868	ribosomal protein
GA597_RS10175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GA597_RS10185	COG1792	Involved in formation and maintenance of cell shape
GA597_RS10210	COG2003	Belongs to the UPF0758 family
GA597_RS10220	COG0285	dihydrofolate synthase activity
GA597_RS10225	COG0525	valine-tRNA ligase activity
GA597_RS10230	COG2818	Glycosylase
GA597_RS10240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GA597_RS10255	COG0181	hydroxymethylbilane synthase activity
GA597_RS10260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GA597_RS10265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GA597_RS10270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GA597_RS10280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GA597_RS10285	COG0544	peptidyl-prolyl cis-trans isomerase activity
GA597_RS10295	COG4112	unkown
GA597_RS10300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GA597_RS10305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GA597_RS10310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GA597_RS10315	COG0833	amino acid
GA597_RS10320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GA597_RS10325	COG1484	DNA-dependent DNA replication
GA597_RS10335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GA597_RS10340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GA597_RS10350	COG0237	dephospho-CoA kinase activity
GA597_RS10360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GA597_RS10360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GA597_RS10365	COG5002	protein histidine kinase activity
GA597_RS10370	COG0745	RESPONSE REGULATOR receiver
GA597_RS10375	COG0538	isocitrate dehydrogenase activity
GA597_RS10380	COG0372	Belongs to the citrate synthase family
GA597_RS10385	COG1113	amino acid transport
GA597_RS10395	COG0469	pyruvate kinase activity
GA597_RS10400	COG0205	6-phosphofructokinase activity
GA597_RS10405	COG0825	malonyl-CoA metabolic process
GA597_RS10410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GA597_RS10415	COG0281	malic enzyme
GA597_RS10420	COG0587	DNA-directed DNA polymerase activity
GA597_RS10425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GA597_RS10430	COG4109	DRTGG domain
GA597_RS10440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GA597_RS10445	COG0006	proline dipeptidase activity
GA597_RS10450	COG0686	Belongs to the AlaDH PNT family
GA597_RS10455	COG0589	response to stress
GA597_RS10460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GA597_RS10465	COG0827	DNA restriction-modification system
GA597_RS10470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GA597_RS10475	COG0730	response to heat
GA597_RS10480	COG0301	tRNA thio-modification
GA597_RS10485	COG1104	cysteine desulfurase activity
GA597_RS10495	COG1956	GAF domain-containing protein
GA597_RS10505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GA597_RS10510	COG0584	glycerophosphoryl diester phosphodiesterase
GA597_RS10515	COG1764	response to oxidative stress
GA597_RS10525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GA597_RS10535	COG1263	PTS System
GA597_RS10535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS10540	COG0204	Acyl-transferase
GA597_RS10545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GA597_RS10575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GA597_RS10585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GA597_RS10590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GA597_RS10595	COG0454	-acetyltransferase
GA597_RS10605	COG1609	Transcriptional regulator
GA597_RS10610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GA597_RS10610	COG1605	Chorismate mutase
GA597_RS10620	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GA597_RS10625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GA597_RS10630	COG1674	ftsk spoiiie
GA597_RS10635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GA597_RS10640	COG4848	Belongs to the UPF0354 family
GA597_RS10645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GA597_RS10650	COG1363	Peptidase, m42
GA597_RS10660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GA597_RS10670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GA597_RS10675	COG0510	thiamine kinase activity
GA597_RS10685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GA597_RS10705	COG1187	pseudouridine synthase activity
GA597_RS10710	COG2244	polysaccharide biosynthetic process
GA597_RS10715	COG2081	HI0933 family
GA597_RS10755	COG1511	domain protein
GA597_RS10755	COG1196	nuclear chromosome segregation
GA597_RS10755	COG4372	Transposase
GA597_RS10770	COG0495	leucyl-tRNA aminoacylation
GA597_RS10775	COG2814	Major facilitator Superfamily
GA597_RS10780	COG1242	4 iron, 4 sulfur cluster binding
GA597_RS10785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GA597_RS10805	COG2267	carboxylic ester hydrolase activity
GA597_RS10810	COG0506	proline dehydrogenase activity
GA597_RS10815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GA597_RS10820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GA597_RS10820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GA597_RS10825	COG0307	riboflavin synthase, alpha
GA597_RS10830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA597_RS10830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GA597_RS10845	COG5632	N-Acetylmuramoyl-L-alanine amidase
GA597_RS10845	COG4193	domain, Protein
GA597_RS10845	COG3266	domain, Protein
GA597_RS10870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GA597_RS10880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GA597_RS10885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GA597_RS10890	COG0656	L-ascorbic acid biosynthetic process
GA597_RS10900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GA597_RS10905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GA597_RS10910	COG1506	peptidase
GA597_RS10915	COG0494	nUDIX hydrolase
GA597_RS10920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GA597_RS10930	COG0318	PFAM AMP-dependent synthetase and ligase
GA597_RS10980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GA597_RS10985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GA597_RS10990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GA597_RS11000	COG4473	ABC transporter
GA597_RS11005	COG1131	(ABC) transporter
GA597_RS11010	COG0537	adenosine 5'-monophosphoramidase activity
GA597_RS11025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GA597_RS11030	COG3481	metal-dependent phosphohydrolase, HD sub domain
GA597_RS11035	COG4717	serine-type aminopeptidase activity
GA597_RS11045	COG3679	Belongs to the UPF0342 family
GA597_RS11050	COG4399	Belongs to the UPF0754 family
GA597_RS11060	COG2197	response regulator
GA597_RS11065	COG4585	Histidine kinase
GA597_RS11065	COG2203	Gaf domain
GA597_RS11070	COG0564	pseudouridine synthase activity
GA597_RS11075	COG0114	fumarate hydratase activity
GA597_RS11090	COG0363	glucosamine-6-phosphate deaminase activity
GA597_RS11100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GA597_RS11105	COG1126	abc transporter atp-binding protein
GA597_RS11110	COG0765	amino acid transport
GA597_RS11290	COG0735	belongs to the Fur family
GA597_RS11295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GA597_RS11300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GA597_RS11305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GA597_RS11310	COG4129	membrane
GA597_RS11320	COG3557	Belongs to the UPF0374 family
GA597_RS11325	COG1194	a g-specific adenine glycosylase
GA597_RS11330	COG1988	membrane-bound metal-dependent
GA597_RS11340	COG1134	teichoic acid transport
GA597_RS11340	COG1388	LysM domain
GA597_RS11350	COG2137	regulation of response to DNA damage stimulus
GA597_RS11355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GA597_RS11360	COG0693	protein deglycase activity
GA597_RS11370	COG0535	radical SAM domain protein
GA597_RS11380	COG1607	acyl-coa hydrolase
GA597_RS11385	COG2309	aminopeptidase activity
GA597_RS11390	COG4840	Belongs to the UPF0435 family
GA597_RS11395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA597_RS11405	COG1295	ribonuclease BN
GA597_RS11410	COG2197	response regulator
GA597_RS11415	COG4585	Histidine kinase
GA597_RS11435	COG4221	oxidoreductase activity
GA597_RS11440	COG0024	Methionine aminopeptidase
GA597_RS11445	COG4129	membrane
GA597_RS11460	COG1528	Iron-storage protein
GA597_RS11470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GA597_RS11480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GA597_RS11485	COG1597	lipid kinase activity
GA597_RS11490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA597_RS11495	COG0154	amidase activity
GA597_RS11500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GA597_RS11505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GA597_RS11520	COG4851	CamS sex pheromone cAM373 precursor
GA597_RS11525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GA597_RS11530	COG0210	DNA helicase
GA597_RS11535	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GA597_RS11540	COG4496	protein, YerC YecD
GA597_RS11545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GA597_RS11555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GA597_RS11560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GA597_RS11565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GA597_RS11575	COG0077	Prephenate dehydratase
GA597_RS11575	COG1605	Chorismate mutase
GA597_RS11585	COG1335	isochorismatase
GA597_RS11590	COG1227	inorganic diphosphatase activity
GA597_RS11595	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS11600	COG2706	6-phosphogluconolactonase activity
GA597_RS11640	COG1131	(ABC) transporter
GA597_RS11655	COG1725	Transcriptional regulator
GA597_RS11720	COG0582	viral genome integration into host DNA
GA597_RS11725	COG0459	protein refolding
GA597_RS11730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GA597_RS11755	COG4512	PFAM Accessory gene regulator B
GA597_RS11770	COG3279	Response regulator of the LytR AlgR family
GA597_RS11775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GA597_RS11780	COG1621	beta-fructofuranosidase activity
GA597_RS11785	COG1609	Transcriptional regulator
GA597_RS11790	COG0004	ammonium transporteR
GA597_RS11795	COG0425	Belongs to the sulfur carrier protein TusA family
GA597_RS11800	COG2391	methyltransferase activity
GA597_RS11805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GA597_RS11810	COG0488	(ABC) transporter
GA597_RS11815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GA597_RS11820	COG0456	acetyltransferase
GA597_RS11825	COG1214	PFAM Peptidase M22, glycoprotease
GA597_RS11830	COG0802	atpase or kinase
GA597_RS11835	COG0129	dihydroxy-acid dehydratase activity
GA597_RS11840	COG0028	Belongs to the TPP enzyme family
GA597_RS11845	COG0440	acetolactate synthase activity
GA597_RS11850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GA597_RS11855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GA597_RS11860	COG0473	3-isopropylmalate dehydrogenase activity
GA597_RS11865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GA597_RS11870	COG0066	3-isopropylmalate dehydratase activity
GA597_RS11875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GA597_RS11915	COG2183	response to ionizing radiation
GA597_RS11920	COG1191	sigma factor activity
GA597_RS11935	COG2208	phosphoserine phosphatase activity
GA597_RS11940	COG2337	Toxic component of a toxin-antitoxin (TA) module
GA597_RS11950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GA597_RS11955	COG0736	holo-[acyl-carrier-protein] synthase activity
GA597_RS11960	COG3402	PFAM membrane-flanked domain
GA597_RS11965	COG3428	Bacterial PH domain
GA597_RS11975	COG0513	Belongs to the DEAD box helicase family
GA597_RS11980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GA597_RS11985	COG1181	Belongs to the D-alanine--D-alanine ligase family
GA597_RS11990	COG0772	Belongs to the SEDS family
GA597_RS12010	COG1937	Protein conserved in bacteria
GA597_RS12015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GA597_RS12020	COG1418	mRNA catabolic process
GA597_RS12030	COG0706	membrane insertase activity
GA597_RS12035	COG0352	thiamine-phosphate diphosphorylase activity
GA597_RS12040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GA597_RS12050	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GA597_RS12055	COG1388	LysM domain
GA597_RS12060	COG0629	single-stranded DNA binding
GA597_RS12070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GA597_RS12075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GA597_RS12085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GA597_RS12090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GA597_RS12095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GA597_RS12100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GA597_RS12105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GA597_RS12110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GA597_RS12115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GA597_RS12120	COG0356	it plays a direct role in the translocation of protons across the membrane
GA597_RS12130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GA597_RS12135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GA597_RS12140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GA597_RS12145	COG4475	Protein of unknown function (DUF436)
GA597_RS12150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GA597_RS12155	COG0009	L-threonylcarbamoyladenylate synthase
GA597_RS12160	COG2890	protein-(glutamine-N5) methyltransferase activity
GA597_RS12165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GA597_RS12170	COG1435	thymidine kinase activity
GA597_RS12175	COG0254	rRNA binding
GA597_RS12180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GA597_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
GA597_RS12195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GA597_RS12200	COG0191	fructose-bisphosphate aldolase activity
GA597_RS12210	COG0504	CTP synthase activity
GA597_RS12225	COG5146	pantothenate kinase activity
GA597_RS12245	COG1854	S-ribosylhomocysteine lyase activity
GA597_RS12255	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GA597_RS12260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GA597_RS12265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GA597_RS12270	COG0813	purine-nucleoside phosphorylase activity
GA597_RS12275	COG0783	Belongs to the Dps family
GA597_RS12295	COG1482	cell wall glycoprotein biosynthetic process
GA597_RS12300	COG0702	epimerase
GA597_RS12305	COG0640	Transcriptional regulator
GA597_RS12330	COG0561	phosphatase activity
GA597_RS12335	COG1119	ATPase activity
GA597_RS12345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GA597_RS12355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GA597_RS12410	COG0489	protein tyrosine kinase activity
GA597_RS12415	COG2814	Major facilitator Superfamily
GA597_RS12430	COG1272	protein, Hemolysin III
GA597_RS12435	COG4284	Utp--glucose-1-phosphate uridylyltransferase
GA597_RS12440	COG1988	membrane-bound metal-dependent
GA597_RS12450	COG2329	Antibiotic biosynthesis monooxygenase
GA597_RS12455	COG3314	Sporulation integral membrane protein YlbJ
GA597_RS12460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS12465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GA597_RS12470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GA597_RS12475	COG3457	Alanine racemase
GA597_RS12485	COG2814	Major facilitator Superfamily
GA597_RS12490	COG4264	IucA IucC family
GA597_RS12510	COG1302	Protein conserved in bacteria
GA597_RS12525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GA597_RS12530	COG0604	alcohol dehydrogenase
GA597_RS12535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GA597_RS12545	COG2723	6-phospho-beta-galactosidase activity
GA597_RS12550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GA597_RS12550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GA597_RS12555	COG1447	Phosphotransferase system cellobiose-specific component IIA
GA597_RS12560	COG3684	Belongs to the aldolase LacD family
GA597_RS12565	COG1105	Belongs to the carbohydrate kinase PfkB family
GA597_RS12570	COG0698	ribose 5-phosphate isomerase
GA597_RS12575	COG0698	ribose 5-phosphate isomerase
GA597_RS12585	COG1349	DNA-binding transcription factor activity
GA597_RS12590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GA597_RS12595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GA597_RS12600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GA597_RS12605	COG0101	tRNA pseudouridine synthase activity
GA597_RS12615	COG1122	ATPase activity
GA597_RS12620	COG1122	ATPase activity
GA597_RS12625	COG0203	ribosomal protein L17
GA597_RS12630	COG0202	RNA polymerase activity
GA597_RS12640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GA597_RS12645	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GA597_RS12650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GA597_RS12655	COG0563	adenylate kinase activity
GA597_RS12660	COG0201	protein transport
GA597_RS12665	COG0200	Binds to the 23S rRNA
GA597_RS12670	COG1841	ribosomal large subunit assembly
GA597_RS12675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GA597_RS12680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GA597_RS12685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GA597_RS12690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GA597_RS12700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GA597_RS12705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GA597_RS12710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GA597_RS12715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GA597_RS12720	COG0255	Belongs to the universal ribosomal protein uL29 family
GA597_RS12725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GA597_RS12730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GA597_RS12735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GA597_RS12740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GA597_RS12745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GA597_RS12750	COG0089	rRNA binding
GA597_RS12755	COG0088	Forms part of the polypeptide exit tunnel
GA597_RS12760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GA597_RS12765	COG0051	transcription antitermination factor activity, RNA binding
GA597_RS12775	COG2252	PERMEase
GA597_RS12780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GA597_RS12780	COG0551	DNA topoisomerase type I activity
GA597_RS12790	COG4975	Glucose uptake
GA597_RS12810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GA597_RS12815	COG2348	transferase activity, transferring amino-acyl groups
GA597_RS12845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GA597_RS12850	COG0746	molybdenum cofactor guanylyltransferase activity
GA597_RS12875	COG0315	cyclic pyranopterin monophosphate synthase activity
GA597_RS12885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GA597_RS12890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GA597_RS12895	COG4149	molybdate abc transporter
GA597_RS12900	COG0725	ABC transporter, periplasmic molybdate-binding protein
GA597_RS12905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GA597_RS12915	COG1268	BioY protein
GA597_RS12920	COG1957	nucleoside hydrolase
GA597_RS12925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GA597_RS12930	COG1960	acyl-CoA dehydrogenase activity
GA597_RS12955	COG3942	CHAP domain
GA597_RS12965	COG1757	Na H antiporter
GA597_RS12980	COG3942	CHAP domain
GA597_RS12985	COG2076	Multidrug Resistance protein
GA597_RS12990	COG2076	Multidrug Resistance protein
GA597_RS12995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GA597_RS13015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GA597_RS13020	COG3383	formate dehydrogenase (NAD+) activity
GA597_RS13025	COG1316	TRANSCRIPTIONal
GA597_RS13035	COG2378	regulation of single-species biofilm formation
GA597_RS13050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GA597_RS13055	COG1263	PTS System
GA597_RS13055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS13070	COG1113	amino acid transport
GA597_RS13090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GA597_RS13100	COG1263	PTS System
GA597_RS13100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS13105	COG1737	Transcriptional regulator
GA597_RS13120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GA597_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
GA597_RS13130	COG1473	amidohydrolase
GA597_RS13140	COG0010	Belongs to the arginase family
GA597_RS13145	COG1266	CAAX protease self-immunity
GA597_RS13155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GA597_RS13160	COG2258	MOSC domain
GA597_RS13170	COG1742	UPF0060 membrane protein
GA597_RS13185	COG2094	Belongs to the DNA glycosylase MPG family
GA597_RS13190	COG0786	glutamate:sodium symporter activity
GA597_RS13195	COG1304	FMN binding
GA597_RS13200	COG0598	Magnesium transport protein CorA
GA597_RS13225	COG2814	Major facilitator Superfamily
GA597_RS13230	COG1566	PFAM secretion protein HlyD family protein
GA597_RS13240	COG2814	Major facilitator Superfamily
GA597_RS13245	COG4640	response to antibiotic
GA597_RS13260	COG1136	(ABC) transporter
GA597_RS13265	COG0577	efflux transmembrane transporter activity
GA597_RS13270	COG0745	RESPONSE REGULATOR receiver
GA597_RS13275	COG5002	protein histidine kinase activity
GA597_RS13275	COG3850	Histidine kinase
GA597_RS13290	COG0579	oxidoreductase
GA597_RS13295	COG0438	transferase activity, transferring glycosyl groups
GA597_RS13300	COG1620	l-lactate permease
GA597_RS13305	COG0463	Glycosyl transferase, family 2
GA597_RS13305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GA597_RS13315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GA597_RS13320	COG0805	protein transport
GA597_RS13325	COG0672	)-iron permease
GA597_RS13330	COG2837	iron assimilation
GA597_RS13335	COG2822	iron ion transport
GA597_RS13340	COG0604	alcohol dehydrogenase
GA597_RS13350	COG0492	ferredoxin-NADP+ reductase activity
GA597_RS13380	COG1511	domain protein
GA597_RS13395	COG1263	PTS System
GA597_RS13395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GA597_RS13410	COG3871	stress protein (general stress protein 26)
GA597_RS13435	COG1846	Transcriptional regulator
GA597_RS13450	COG2223	nitrite transmembrane transporter activity
GA597_RS13455	COG2197	response regulator
GA597_RS13460	COG4585	Histidine kinase
GA597_RS13470	COG2181	nitrate reductase activity
GA597_RS13475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GA597_RS13480	COG1140	nitrate reductase beta subunit
GA597_RS13485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GA597_RS13495	COG2146	nitrite reductase [NAD(P)H] activity