locus-tag	class	description
EGX58_RS00030	COG0640	Transcriptional regulator
EGX58_RS00055	COG1511	domain protein
EGX58_RS00065	COG1611	Belongs to the LOG family
EGX58_RS00100	COG1230	cation diffusion facilitator family transporter
EGX58_RS00110	COG1937	Protein conserved in bacteria
EGX58_RS00115	COG2217	Heavy metal translocating P-type atpase
EGX58_RS00135	COG1131	(ABC) transporter
EGX58_RS00180	COG0589	response to stress
EGX58_RS00200	COG2197	response regulator
EGX58_RS00205	COG4585	Histidine kinase
EGX58_RS00215	COG1131	(ABC) transporter
EGX58_RS00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGX58_RS00240	COG0789	Transcriptional regulator
EGX58_RS00250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EGX58_RS00255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGX58_RS00260	COG0386	Belongs to the glutathione peroxidase family
EGX58_RS00265	COG1923	regulation of RNA biosynthetic process
EGX58_RS00270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGX58_RS00275	COG2267	carboxylic ester hydrolase activity
EGX58_RS00280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGX58_RS00285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGX58_RS00290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGX58_RS00295	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EGX58_RS00300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGX58_RS00305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EGX58_RS00320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGX58_RS00330	COG4195	phage-related replication protein
EGX58_RS00335	COG1013	pyruvate-flavodoxin oxidoreductase activity
EGX58_RS00340	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGX58_RS00340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGX58_RS00345	COG1692	metallophosphoesterase
EGX58_RS00355	COG1418	mRNA catabolic process
EGX58_RS00360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGX58_RS00365	COG1058	Belongs to the CinA family
EGX58_RS00365	COG1546	Belongs to the CinA family
EGX58_RS00385	COG0300	oxidoreductase activity
EGX58_RS00390	COG0612	Peptidase, M16
EGX58_RS00395	COG0612	Peptidase, M16
EGX58_RS00400	COG2188	Transcriptional regulator
EGX58_RS00405	COG1674	ftsk spoiiie
EGX58_RS00410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EGX58_RS00415	COG1185	polyribonucleotide nucleotidyltransferase activity
EGX58_RS00420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGX58_RS00425	COG0196	riboflavin kinase activity
EGX58_RS00430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGX58_RS00435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGX58_RS00440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EGX58_RS00450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EGX58_RS00455	COG0195	Participates in both transcription termination and antitermination
EGX58_RS00460	COG0779	Required for maturation of 30S ribosomal subunits
EGX58_RS00465	COG2176	DNA-directed DNA polymerase activity
EGX58_RS00470	COG0442	prolyl-tRNA aminoacylation
EGX58_RS00480	COG4589	Belongs to the CDS family
EGX58_RS00485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGX58_RS00490	COG0233	cytoplasmic translational termination
EGX58_RS00495	COG0528	UMP kinase activity
EGX58_RS00500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGX58_RS00505	COG0052	Belongs to the universal ribosomal protein uS2 family
EGX58_RS00510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EGX58_RS00515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EGX58_RS00520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EGX58_RS00525	COG4974	Belongs to the 'phage' integrase family
EGX58_RS00530	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EGX58_RS00535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGX58_RS00540	COG0758	DNA mediated transformation
EGX58_RS00545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGX58_RS00550	COG0045	succinate-CoA ligase (ADP-forming) activity
EGX58_RS00555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGX58_RS00565	COG4485	Bacterial membrane protein, YfhO
EGX58_RS00580	COG0335	large ribosomal subunit rRNA binding
EGX58_RS00585	COG0336	Belongs to the RNA methyltransferase TrmD family
EGX58_RS00590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGX58_RS00595	COG0228	four-way junction DNA binding
EGX58_RS00600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGX58_RS00605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EGX58_RS00610	COG0552	protein localization to endoplasmic reticulum
EGX58_RS00615	COG1196	nuclear chromosome segregation
EGX58_RS00620	COG0571	ribonuclease III activity
EGX58_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGX58_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS00640	COG0416	fatty acid biosynthetic process
EGX58_RS00645	COG1349	DNA-binding transcription factor activity
EGX58_RS00655	COG1461	Dihydroxyacetone kinase
EGX58_RS00660	COG1302	Protein conserved in bacteria
EGX58_RS00665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGX58_RS00670	COG1564	THIamine pyrophosphokinase
EGX58_RS00675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGX58_RS00680	COG1162	GTPase activity
EGX58_RS00690	COG0631	protein serine/threonine phosphatase activity
EGX58_RS00695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGX58_RS00700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGX58_RS00700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGX58_RS00705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGX58_RS00715	COG2314	TM2 domain
EGX58_RS00720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGX58_RS00725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGX58_RS00730	COG1758	RNA polymerase activity
EGX58_RS00735	COG0194	GDP metabolic process
EGX58_RS00740	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EGX58_RS00755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EGX58_RS00760	COG0284	orotidine-5'-phosphate decarboxylase activity
EGX58_RS00765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGX58_RS00770	COG0505	Belongs to the CarA family
EGX58_RS00780	COG0540	Belongs to the ATCase OTCase family
EGX58_RS00785	COG2233	PERMEase
EGX58_RS00790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EGX58_RS00795	COG0564	pseudouridine synthase activity
EGX58_RS00800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGX58_RS00805	COG3942	CHAP domain
EGX58_RS00805	COG1388	LysM domain
EGX58_RS00815	COG0702	epimerase
EGX58_RS00820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGX58_RS00825	COG3599	regulation of cell shape
EGX58_RS00835	COG0762	integral membrane protein
EGX58_RS00840	COG1799	cell septum assembly
EGX58_RS00845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGX58_RS00850	COG1496	oxidoreductase activity
EGX58_RS00855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGX58_RS00860	COG0849	cell division
EGX58_RS00865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGX58_RS00870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGX58_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGX58_RS00880	COG0768	penicillin binding
EGX58_RS00885	COG4839	cell division protein FtsL
EGX58_RS00890	COG0275	rRNA processing
EGX58_RS00895	COG2001	Belongs to the MraZ family
EGX58_RS00900	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EGX58_RS00905	COG1011	Hydrolase
EGX58_RS00985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGX58_RS00990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGX58_RS00995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGX58_RS01000	COG1053	succinate dehydrogenase
EGX58_RS01005	COG2009	succinate dehydrogenase
EGX58_RS01010	COG0322	excinuclease ABC activity
EGX58_RS01015	COG3118	belongs to the thioredoxin family
EGX58_RS01020	COG1193	negative regulation of DNA recombination
EGX58_RS01025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EGX58_RS01025	COG1796	DNA polymerase
EGX58_RS01040	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGX58_RS01045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGX58_RS01045	COG0072	phenylalanine-tRNA ligase activity
EGX58_RS01050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGX58_RS01055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGX58_RS01060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGX58_RS01070	COG1323	Belongs to the UPF0348 family
EGX58_RS01075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGX58_RS01080	COG0742	ribosomal rna small subunit methyltransferase
EGX58_RS01095	COG0584	glycerophosphoryl diester phosphodiesterase
EGX58_RS01100	COG3679	Belongs to the UPF0342 family
EGX58_RS01115	COG0109	protoheme IX farnesyltransferase activity
EGX58_RS01120	COG1612	heme a metabolic process
EGX58_RS01130	COG0772	Belongs to the SEDS family
EGX58_RS01135	COG4838	Belongs to the UPF0358 family
EGX58_RS01140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGX58_RS01150	COG1217	gtp-binding protein TYPA
EGX58_RS01160	COG0483	inositol monophosphate 1-phosphatase activity
EGX58_RS01170	COG4493	Belongs to the UPF0637 family
EGX58_RS01175	COG1914	H( )-stimulated, divalent metal cation uptake system
EGX58_RS01185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGX58_RS01195	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGX58_RS01200	COG3842	ATPase activity
EGX58_RS01205	COG1396	sequence-specific DNA binding
EGX58_RS01205	COG3800	Transcriptional regulator
EGX58_RS01210	COG4476	Belongs to the UPF0223 family
EGX58_RS01220	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGX58_RS01240	COG0242	peptide deformylase activity
EGX58_RS01245	COG5503	Protein of unknown function (DUF1447)
EGX58_RS01250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EGX58_RS01255	COG0569	domain protein
EGX58_RS01260	COG1294	oxidase, subunit
EGX58_RS01265	COG1271	oxidase subunit
EGX58_RS01275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGX58_RS01290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EGX58_RS01310	COG4172	Belongs to the ABC transporter superfamily
EGX58_RS01315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EGX58_RS01320	COG0151	Belongs to the GarS family
EGX58_RS01325	COG0138	bifunctional purine biosynthesis protein purh
EGX58_RS01335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGX58_RS01345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGX58_RS01350	COG0047	phosphoribosylformylglycinamidine synthase activity
EGX58_RS01355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGX58_RS01360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGX58_RS01365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGX58_RS01370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGX58_RS01375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGX58_RS01380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGX58_RS01380	COG1017	nitric oxide dioxygenase activity
EGX58_RS01390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EGX58_RS01395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGX58_RS01400	COG1845	cytochrome c oxidase, subunit III
EGX58_RS01405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EGX58_RS01420	COG1316	TRANSCRIPTIONal
EGX58_RS01435	COG5632	N-Acetylmuramoyl-L-alanine amidase
EGX58_RS01435	COG4193	domain, Protein
EGX58_RS01435	COG3266	domain, Protein
EGX58_RS01445	COG0436	Aminotransferase
EGX58_RS01450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EGX58_RS01460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EGX58_RS01465	COG1169	isochorismate synthase
EGX58_RS01470	COG1575	Belongs to the MenA family. Type 1 subfamily
EGX58_RS01480	COG2314	TM2 domain
EGX58_RS01680	COG1484	DNA-dependent DNA replication
EGX58_RS01765	COG4873	Protein conserved in bacteria
EGX58_RS01775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGX58_RS01780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGX58_RS01785	COG0861	Integral membrane protein TerC family
EGX58_RS01790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGX58_RS01800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGX58_RS01805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGX58_RS01810	COG2814	Major facilitator Superfamily
EGX58_RS01815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EGX58_RS01820	COG2382	esterase
EGX58_RS01825	COG0628	permease
EGX58_RS01835	COG0569	domain protein
EGX58_RS01835	COG0475	glutathione-regulated potassium exporter activity
EGX58_RS01840	COG2239	Acts as a magnesium transporter
EGX58_RS01845	COG0564	pseudouridine synthase activity
EGX58_RS01855	COG2357	RelA SpoT domain protein
EGX58_RS01870	COG2346	COG2346, Truncated hemoglobins
EGX58_RS01875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EGX58_RS01880	COG1164	Oligoendopeptidase f
EGX58_RS01890	COG4862	establishment of competence for transformation
EGX58_RS01895	COG1393	Belongs to the ArsC family
EGX58_RS01900	COG0180	Tryptophanyl-tRNA synthetase
EGX58_RS01905	COG4166	transmembrane transport
EGX58_RS01910	COG4608	Belongs to the ABC transporter superfamily
EGX58_RS01915	COG0444	Belongs to the ABC transporter superfamily
EGX58_RS01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGX58_RS01925	COG0601	transmembrane transport
EGX58_RS01940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGX58_RS01950	COG0542	response to heat
EGX58_RS01965	COG0561	phosphatase activity
EGX58_RS01970	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGX58_RS01980	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGX58_RS01985	COG1074	ATP-dependent DNA helicase activity
EGX58_RS01990	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EGX58_RS02005	COG0398	Pfam SNARE associated Golgi protein
EGX58_RS02010	COG0166	Belongs to the GPI family
EGX58_RS02015	COG0137	argininosuccinate synthase activity
EGX58_RS02020	COG0165	Argininosuccinate lyase
EGX58_RS02025	COG0584	glycerophosphoryl diester phosphodiesterase
EGX58_RS02040	COG1902	pentaerythritol trinitrate reductase activity
EGX58_RS02045	COG1098	S1 RNA binding domain
EGX58_RS02050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGX58_RS02060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGX58_RS02060	COG2111	Na H antiporter
EGX58_RS02065	COG2111	Na H antiporter
EGX58_RS02070	COG1006	Multisubunit Na H antiporter MnhC subunit
EGX58_RS02075	COG0651	ATP synthesis coupled electron transport
EGX58_RS02080	COG1863	multisubunit Na H antiporter MnhE subunit
EGX58_RS02085	COG2212	antiporter activity
EGX58_RS02090	COG1320	monovalent cation:proton antiporter activity
EGX58_RS02100	COG2050	protein possibly involved in aromatic compounds catabolism
EGX58_RS02105	COG2056	Na+-H+ antiporter family
EGX58_RS02110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGX58_RS02115	COG1252	NADH dehydrogenase
EGX58_RS02120	COG0316	Belongs to the HesB IscA family
EGX58_RS02125	COG4844	belongs to the
EGX58_RS02130	COG1252	NADH dehydrogenase
EGX58_RS02135	COG4837	Protein of unknown function (DUF1462)
EGX58_RS02140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EGX58_RS02145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EGX58_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGX58_RS02155	COG1696	Membrane protein involved in D-alanine export
EGX58_RS02160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGX58_RS02170	COG0647	UMP catabolic process
EGX58_RS02175	COG2445	Protein of unknown function DUF86
EGX58_RS02185	COG4470	Protein conserved in bacteria
EGX58_RS02190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGX58_RS02195	COG0737	Belongs to the 5'-nucleotidase family
EGX58_RS02200	COG0730	response to heat
EGX58_RS02205	COG1801	Protein of unknown function DUF72
EGX58_RS02210	COG0719	Fe-S assembly protein
EGX58_RS02215	COG0822	iron-sulfur transferase activity
EGX58_RS02220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGX58_RS02225	COG0719	Fe-S assembly protein
EGX58_RS02230	COG0396	ATPase activity
EGX58_RS02240	COG3237	CsbD-like
EGX58_RS02245	COG1464	Belongs to the NlpA lipoprotein family
EGX58_RS02250	COG2011	ABC-type metal ion transport system permease component
EGX58_RS02255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGX58_RS02265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EGX58_RS02270	COG0509	glycine decarboxylation via glycine cleavage system
EGX58_RS02275	COG1393	Belongs to the ArsC family
EGX58_RS02280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGX58_RS02290	COG0710	3-dehydroquinate dehydratase activity
EGX58_RS02295	COG1764	response to oxidative stress
EGX58_RS02335	COG4195	phage-related replication protein
EGX58_RS02365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGX58_RS02370	COG0557	exoribonuclease II activity
EGX58_RS02375	COG1647	Serine aminopeptidase, S33
EGX58_RS02380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGX58_RS02390	COG0148	phosphopyruvate hydratase activity
EGX58_RS02395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EGX58_RS02400	COG0149	triose-phosphate isomerase activity
EGX58_RS02405	COG0126	phosphoglycerate kinase activity
EGX58_RS02415	COG2390	Transcriptional regulator
EGX58_RS02430	COG1090	epimerase
EGX58_RS02440	COG0740	serine-type endopeptidase activity
EGX58_RS02450	COG1481	regulation of sporulation
EGX58_RS02455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EGX58_RS02460	COG1660	Displays ATPase and GTPase activities
EGX58_RS02475	COG0110	maltose O-acetyltransferase activity
EGX58_RS02480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EGX58_RS02485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGX58_RS02490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGX58_RS02495	COG0556	nucleotide-excision repair
EGX58_RS02510	COG3942	CHAP domain
EGX58_RS02510	COG1388	LysM domain
EGX58_RS02520	COG0653	protein targeting
EGX58_RS02525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EGX58_RS02530	COG1040	competence protein
EGX58_RS02535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EGX58_RS02545	COG1739	Uncharacterized protein family UPF0029
EGX58_RS02550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGX58_RS02555	COG2199	diguanylate cyclase activity
EGX58_RS02570	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGX58_RS02575	COG1929	Belongs to the glycerate kinase type-1 family
EGX58_RS02580	COG3118	belongs to the thioredoxin family
EGX58_RS02595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGX58_RS02605	COG4607	ABC-type enterochelin transport system periplasmic component
EGX58_RS02610	COG4604	ABC transporter, ATP-binding protein
EGX58_RS02615	COG4605	iron ion homeostasis
EGX58_RS02620	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGX58_RS02625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGX58_RS02630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGX58_RS02635	COG1780	Probably involved in ribonucleotide reductase function
EGX58_RS02645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGX58_RS02650	COG3104	oligopeptide transport
EGX58_RS02655	COG1597	lipid kinase activity
EGX58_RS02665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGX58_RS02670	COG1174	glycine betaine transport
EGX58_RS02675	COG1125	glycine betaine transport
EGX58_RS02675	COG0517	IMP dehydrogenase activity
EGX58_RS02680	COG0514	ATP-dependent DNA helicase (RecQ)
EGX58_RS02685	COG0488	(ABC) transporter
EGX58_RS02695	COG1368	sulfuric ester hydrolase activity
EGX58_RS02720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGX58_RS02725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGX58_RS02725	COG0512	Glutamine amidotransferase of anthranilate synthase
EGX58_RS02730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGX58_RS02735	COG0720	synthase
EGX58_RS02740	COG0602	queuosine metabolic process
EGX58_RS02750	COG0463	Glycosyl transferase, family 2
EGX58_RS02755	COG0656	L-ascorbic acid biosynthetic process
EGX58_RS02760	COG1253	flavin adenine dinucleotide binding
EGX58_RS02765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGX58_RS02765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGX58_RS02765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGX58_RS02770	COG1105	Belongs to the carbohydrate kinase PfkB family
EGX58_RS02775	COG1349	DNA-binding transcription factor activity
EGX58_RS02780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGX58_RS02805	COG0415	Belongs to the DNA photolyase family
EGX58_RS02815	COG0523	cobalamin synthesis protein
EGX58_RS02825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGX58_RS02830	COG4988	ABC transporter
EGX58_RS02835	COG1968	undecaprenyl-diphosphatase activity
EGX58_RS02845	COG1671	Belongs to the UPF0178 family
EGX58_RS02850	COG1611	Belongs to the LOG family
EGX58_RS02885	COG0583	DNA-binding transcription factor activity
EGX58_RS02895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGX58_RS02905	COG0217	transcriptional regulatory protein
EGX58_RS02915	COG2207	Transcriptional regulator
EGX58_RS02915	COG0662	Cupin 2, conserved barrel domain protein
EGX58_RS02925	COG3942	CHAP domain
EGX58_RS02925	COG1388	LysM domain
EGX58_RS02930	COG0306	phosphate transporter
EGX58_RS02935	COG1392	Phosphate transport regulator
EGX58_RS02940	COG0577	efflux transmembrane transporter activity
EGX58_RS02945	COG1136	(ABC) transporter
EGX58_RS02950	COG2205	protein histidine kinase activity
EGX58_RS02955	COG0745	RESPONSE REGULATOR receiver
EGX58_RS02960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGX58_RS02970	COG3949	Membrane
EGX58_RS02980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EGX58_RS02985	COG1120	ATPase activity
EGX58_RS02990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EGX58_RS02995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EGX58_RS03000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EGX58_RS03000	COG0463	Glycosyl transferase, family 2
EGX58_RS03005	COG1132	(ABC) transporter
EGX58_RS03010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGX58_RS03020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EGX58_RS03025	COG1682	transport, permease protein
EGX58_RS03030	COG1134	teichoic acid transport
EGX58_RS03035	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EGX58_RS03050	COG0025	NhaP-type Na H and K H
EGX58_RS03055	COG1320	monovalent cation:proton antiporter activity
EGX58_RS03060	COG2212	antiporter activity
EGX58_RS03065	COG1863	multisubunit Na H antiporter MnhE subunit
EGX58_RS03070	COG0651	ATP synthesis coupled electron transport
EGX58_RS03075	COG1006	Multisubunit Na H antiporter MnhC subunit
EGX58_RS03080	COG2111	Na H antiporter
EGX58_RS03085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGX58_RS03085	COG2111	Na H antiporter
EGX58_RS03140	COG0546	phosphoglycolate phosphatase activity
EGX58_RS03145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGX58_RS03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGX58_RS03160	COG0789	Transcriptional regulator
EGX58_RS03160	COG4978	Transcriptional regulator
EGX58_RS03165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGX58_RS03170	COG0018	arginyl-trna synthetase
EGX58_RS03195	COG1078	dGTPase activity
EGX58_RS03205	COG0655	NAD(P)H dehydrogenase (quinone) activity
EGX58_RS03210	COG0667	Aldo Keto reductase
EGX58_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGX58_RS03225	COG4844	belongs to the
EGX58_RS03245	COG0095	Lipoate-protein ligase
EGX58_RS03255	COG3253	May function as heme-dependent peroxidase
EGX58_RS03270	COG0531	amino acid
EGX58_RS03275	COG2363	Small membrane protein
EGX58_RS03285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGX58_RS03310	COG0183	Belongs to the thiolase family
EGX58_RS03315	COG0318	PFAM AMP-dependent synthetase and ligase
EGX58_RS03320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGX58_RS03325	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EGX58_RS03335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EGX58_RS03340	COG1469	GTP cyclohydrolase I activity
EGX58_RS03355	COG0431	NADPH-dependent FMN reductase
EGX58_RS03360	COG0561	phosphatase activity
EGX58_RS03370	COG1428	Deoxynucleoside kinase
EGX58_RS03375	COG1428	Deoxynucleoside kinase
EGX58_RS03380	COG0546	phosphoglycolate phosphatase activity
EGX58_RS03420	COG3728	DNA packaging
EGX58_RS03420	COG5484	DNA packaging
EGX58_RS03480	COG0582	viral genome integration into host DNA
EGX58_RS03485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGX58_RS03490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGX58_RS03495	COG0737	Belongs to the 5'-nucleotidase family
EGX58_RS03505	COG0494	nUDIX hydrolase
EGX58_RS03520	COG1473	amidohydrolase
EGX58_RS03525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGX58_RS03530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGX58_RS03540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGX58_RS03550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGX58_RS03555	COG0085	RNA polymerase activity
EGX58_RS03560	COG2813	Specifically methylates the guanine in position
EGX58_RS03565	COG0222	ribosome binding
EGX58_RS03570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGX58_RS03580	COG0081	regulation of translation
EGX58_RS03585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EGX58_RS03590	COG0250	Participates in transcription elongation, termination and antitermination
EGX58_RS03595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGX58_RS03600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGX58_RS03610	COG3688	RNA-binding protein containing a PIN domain
EGX58_RS03615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGX58_RS03620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EGX58_RS03625	COG0215	cysteine-tRNA ligase activity
EGX58_RS03630	COG1045	serine acetyltransferase
EGX58_RS03635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGX58_RS03640	COG4956	integral membrane protein (PIN domain superfamily)
EGX58_RS03645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EGX58_RS03650	COG0542	response to heat
EGX58_RS03655	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EGX58_RS03660	COG3880	PFAM UvrB UvrC protein
EGX58_RS03665	COG4463	regulation of RNA biosynthetic process
EGX58_RS03670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EGX58_RS03675	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EGX58_RS03680	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EGX58_RS03685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGX58_RS03770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGX58_RS03775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGX58_RS03790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGX58_RS03795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGX58_RS03800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGX58_RS03815	COG1098	S1 RNA binding domain
EGX58_RS03825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EGX58_RS03830	COG3956	TIGRFAM MazG family protein
EGX58_RS03835	COG2244	polysaccharide biosynthetic process
EGX58_RS03840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGX58_RS03845	COG0193	aminoacyl-tRNA hydrolase activity
EGX58_RS03850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGX58_RS03855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGX58_RS03860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGX58_RS03865	COG2088	sporulation resulting in formation of a cellular spore
EGX58_RS03870	COG0251	oxidation-reduction process
EGX58_RS03875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGX58_RS03880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EGX58_RS03885	COG4466	Protein conserved in bacteria
EGX58_RS03890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGX58_RS03895	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EGX58_RS03900	COG0084	hydrolase, TatD family'
EGX58_RS03905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGX58_RS03905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGX58_RS03910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGX58_RS03915	COG2827	Endonuclease containing a URI domain
EGX58_RS03920	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EGX58_RS03925	COG4467	Involved in initiation control of chromosome replication
EGX58_RS03930	COG1774	PSP1 C-terminal conserved region
EGX58_RS03935	COG0470	DNA polymerase III
EGX58_RS03940	COG3870	Protein conserved in bacteria
EGX58_RS03945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGX58_RS03950	COG1982	Orn Lys Arg decarboxylase major
EGX58_RS03970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGX58_RS03980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGX58_RS03995	COG2188	Transcriptional regulator
EGX58_RS04000	COG0366	Alpha amylase catalytic
EGX58_RS04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGX58_RS04005	COG1263	PTS System
EGX58_RS04015	COG0493	'glutamate synthase
EGX58_RS04020	COG0070	glutamate synthase
EGX58_RS04020	COG0069	glutamate synthase activity
EGX58_RS04020	COG0067	glutamate synthase
EGX58_RS04040	COG0494	nUDIX hydrolase
EGX58_RS04050	COG3942	CHAP domain
EGX58_RS04050	COG1388	LysM domain
EGX58_RS04060	COG2011	ABC-type metal ion transport system permease component
EGX58_RS04065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGX58_RS04070	COG0626	cystathionine gamma-synthase activity
EGX58_RS04075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGX58_RS04085	COG0733	neurotransmitter:sodium symporter activity
EGX58_RS04095	COG1647	Serine aminopeptidase, S33
EGX58_RS04100	COG0671	phosphoesterase, PA-phosphatase related
EGX58_RS04105	COG5609	conserved protein (DUF2294)
EGX58_RS04110	COG3002	Belongs to the UPF0753 family
EGX58_RS04115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EGX58_RS04125	COG0519	Catalyzes the synthesis of GMP from XMP
EGX58_RS04125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGX58_RS04130	COG0516	GMP reductase activity
EGX58_RS04130	COG0517	IMP dehydrogenase activity
EGX58_RS04135	COG2233	PERMEase
EGX58_RS04140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGX58_RS04155	COG5183	chlorophyll binding
EGX58_RS04160	COG1823	symporter activity
EGX58_RS04165	COG0778	Nitroreductase
EGX58_RS04175	COG0450	alkyl hydroperoxide reductase
EGX58_RS04180	COG3634	alkyl hydroperoxide reductase activity
EGX58_RS04190	COG0406	alpha-ribazole phosphatase activity
EGX58_RS04205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGX58_RS04215	COG0360	Binds together with S18 to 16S ribosomal RNA
EGX58_RS04225	COG0012	GTP binding
EGX58_RS04230	COG4481	Protein conserved in bacteria
EGX58_RS04235	COG0668	transmembrane transport
EGX58_RS04240	COG1475	DNA binding
EGX58_RS04250	COG0626	cystathionine gamma-synthase activity
EGX58_RS04255	COG0626	cystathionine gamma-synthase activity
EGX58_RS04260	COG0646	methionine synthase
EGX58_RS04260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGX58_RS04265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGX58_RS04275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGX58_RS04285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGX58_RS04300	COG1136	(ABC) transporter
EGX58_RS04305	COG0577	efflux transmembrane transporter activity
EGX58_RS04340	COG0357	Ribosomal RNA small subunit methyltransferase G
EGX58_RS04345	COG0445	tRNA wobble uridine modification
EGX58_RS04350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGX58_RS04355	COG0594	ribonuclease P activity
EGX58_RS04365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGX58_RS04370	COG0592	DNA-directed DNA polymerase activity
EGX58_RS04375	COG2501	S4 domain
EGX58_RS04380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EGX58_RS04385	COG0187	DNA topoisomerase II activity
EGX58_RS04390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGX58_RS04395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGX58_RS04400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGX58_RS04405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EGX58_RS04415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGX58_RS04425	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EGX58_RS04430	COG0359	binds to the 23S rRNA
EGX58_RS04435	COG0305	Participates in initiation and elongation during chromosome replication
EGX58_RS04440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGX58_RS04455	COG0745	RESPONSE REGULATOR receiver
EGX58_RS04460	COG5002	protein histidine kinase activity
EGX58_RS04465	COG4863	YycH protein
EGX58_RS04475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGX58_RS04480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGX58_RS04565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGX58_RS04570	COG2210	Belongs to the sulfur carrier protein TusA family
EGX58_RS04575	COG1937	Protein conserved in bacteria
EGX58_RS04580	COG0730	response to heat
EGX58_RS04590	COG1388	LysM domain
EGX58_RS04610	COG1131	(ABC) transporter
EGX58_RS04630	COG1396	sequence-specific DNA binding
EGX58_RS04660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGX58_RS04690	COG0640	Transcriptional regulator
EGX58_RS04705	COG2217	Heavy metal translocating P-type atpase
EGX58_RS04710	COG1388	LysM domain
EGX58_RS04720	COG1063	alcohol dehydrogenase
EGX58_RS04730	COG1064	alcohol dehydrogenase
EGX58_RS04740	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EGX58_RS04745	COG1278	Cold shock
EGX58_RS04760	COG0523	cobalamin synthesis protein
EGX58_RS04775	COG0589	response to stress
EGX58_RS04780	COG0668	transmembrane transport
EGX58_RS04795	COG0471	metal ion transport
EGX58_RS04810	COG1114	Component of the transport system for branched-chain amino acids
EGX58_RS04815	COG1401	restriction endodeoxyribonuclease activity
EGX58_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGX58_RS04830	COG1113	amino acid transport
EGX58_RS04840	COG0753	catalase activity
EGX58_RS04840	COG0693	protein deglycase activity
EGX58_RS04845	COG0346	lactoylglutathione lyase activity
EGX58_RS04890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EGX58_RS04895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EGX58_RS04900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EGX58_RS04910	COG1876	peptidase activity
EGX58_RS04925	COG1288	antiporter activity
EGX58_RS04940	COG2814	Major facilitator Superfamily
EGX58_RS04950	COG1846	Transcriptional regulator
EGX58_RS04955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGX58_RS04960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EGX58_RS04965	COG2855	membrane
EGX58_RS04970	COG0583	DNA-binding transcription factor activity
EGX58_RS04985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGX58_RS05000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGX58_RS05005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGX58_RS05010	COG0022	dehydrogenase e1 component
EGX58_RS05015	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGX58_RS05035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGX58_RS05040	COG2962	Rard protein
EGX58_RS05070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGX58_RS05070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGX58_RS05105	COG0753	catalase activity
EGX58_RS05110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGX58_RS05140	COG1131	(ABC) transporter
EGX58_RS05170	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGX58_RS05200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGX58_RS05205	COG0549	Belongs to the carbamate kinase family
EGX58_RS05210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGX58_RS05220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EGX58_RS05230	COG0363	glucosamine-6-phosphate deaminase activity
EGX58_RS05235	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EGX58_RS05240	COG1737	Transcriptional regulator
EGX58_RS05250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGX58_RS05255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGX58_RS05275	COG1124	(ABC) transporter
EGX58_RS05280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGX58_RS05295	COG0747	negative chemotaxis
EGX58_RS05300	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EGX58_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS05310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EGX58_RS05320	COG1054	Belongs to the UPF0176 family
EGX58_RS05325	COG3386	PFAM SMP-30 Gluconolaconase
EGX58_RS05330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGX58_RS05335	COG0829	nickel cation binding
EGX58_RS05350	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EGX58_RS05355	COG0804	urea catabolic process
EGX58_RS05360	COG0832	Belongs to the urease beta subunit family
EGX58_RS05370	COG4413	Urea transporter
EGX58_RS05375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGX58_RS05385	COG1686	Belongs to the peptidase S11 family
EGX58_RS05395	COG4716	Myosin-crossreactive antigen
EGX58_RS05415	COG1131	(ABC) transporter
EGX58_RS05425	COG1476	TRANSCRIPTIONal
EGX58_RS05430	COG1959	2 iron, 2 sulfur cluster binding
EGX58_RS05440	COG2814	Major facilitator Superfamily
EGX58_RS05445	COG0737	Belongs to the 5'-nucleotidase family
EGX58_RS05460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EGX58_RS05480	COG3391	amine dehydrogenase activity
EGX58_RS05485	COG0201	protein transport
EGX58_RS05505	COG0653	protein targeting
EGX58_RS05520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGX58_RS05535	COG2814	Major facilitator Superfamily
EGX58_RS05545	COG2113	Glycine betaine
EGX58_RS05550	COG2409	Drug exporters of the RND superfamily
EGX58_RS05555	COG0583	DNA-binding transcription factor activity
EGX58_RS05560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGX58_RS05570	COG1288	antiporter activity
EGX58_RS05575	COG3942	CHAP domain
EGX58_RS05575	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGX58_RS05605	COG2235	arginine
EGX58_RS05620	COG2843	Capsule synthesis protein
EGX58_RS05625	COG3961	Belongs to the TPP enzyme family
EGX58_RS05715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGX58_RS05730	COG1785	Belongs to the alkaline phosphatase family
EGX58_RS05735	COG0745	RESPONSE REGULATOR receiver
EGX58_RS05740	COG2205	protein histidine kinase activity
EGX58_RS05745	COG1136	(ABC) transporter
EGX58_RS05760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGX58_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS05770	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGX58_RS05800	COG0175	sulfate reduction
EGX58_RS05805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGX58_RS05810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGX58_RS05825	COG0730	response to heat
EGX58_RS05830	COG2046	Belongs to the sulfate adenylyltransferase family
EGX58_RS05835	COG0529	Catalyzes the synthesis of activated sulfate
EGX58_RS05840	COG3942	CHAP domain
EGX58_RS05850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EGX58_RS05855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGX58_RS05860	COG1510	regulation of RNA biosynthetic process
EGX58_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS05870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EGX58_RS05875	COG1473	amidohydrolase
EGX58_RS05890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGX58_RS05895	COG0574	Belongs to the PEP-utilizing enzyme family
EGX58_RS05895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGX58_RS05900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGX58_RS05905	COG0579	oxidoreductase
EGX58_RS05910	COG3588	fructose-bisphosphate aldolase
EGX58_RS05935	COG1464	Belongs to the NlpA lipoprotein family
EGX58_RS05945	COG0531	amino acid
EGX58_RS05950	COG0028	Belongs to the TPP enzyme family
EGX58_RS05955	COG3527	Alpha-acetolactate decarboxylase
EGX58_RS05965	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGX58_RS05975	COG0167	dihydroorotate dehydrogenase activity
EGX58_RS05980	COG3001	Fructosamine kinase
EGX58_RS06000	COG2226	methyltransferase
EGX58_RS06010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGX58_RS06015	COG1309	transcriptional regulator
EGX58_RS06030	COG0741	lytic transglycosylase activity
EGX58_RS06040	COG1233	COG1233 Phytoene dehydrogenase and related
EGX58_RS06045	COG0463	Glycosyl transferase, family 2
EGX58_RS06050	COG1562	ergosterol biosynthetic process
EGX58_RS06055	COG1233	COG1233 Phytoene dehydrogenase and related
EGX58_RS06060	COG0436	Aminotransferase
EGX58_RS06070	COG2608	mercury ion transmembrane transporter activity
EGX58_RS06075	COG2217	Heavy metal translocating P-type atpase
EGX58_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS06095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EGX58_RS06100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGX58_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS06135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGX58_RS06140	COG3425	synthase
EGX58_RS06155	COG1388	LysM domain
EGX58_RS06155	COG3942	CHAP domain
EGX58_RS06165	COG0583	DNA-binding transcription factor activity
EGX58_RS06170	COG1380	Effector of murein hydrolase LrgA
EGX58_RS06175	COG1346	cytolysis
EGX58_RS06180	COG0028	Belongs to the TPP enzyme family
EGX58_RS06185	COG1263	PTS System
EGX58_RS06185	COG2190	(PTS) system
EGX58_RS06185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGX58_RS06195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGX58_RS06200	COG0039	L-malate dehydrogenase activity
EGX58_RS06215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGX58_RS06235	COG1070	Carbohydrate kinase
EGX58_RS06250	COG1760	l-serine dehydratase
EGX58_RS06255	COG1760	l-serine dehydratase
EGX58_RS06270	COG3764	Sortase (surface protein transpeptidase)
EGX58_RS06275	COG0561	phosphatase activity
EGX58_RS06285	COG0778	Nitroreductase
EGX58_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS06300	COG2514	catechol 2,3-dioxygenase activity
EGX58_RS06310	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGX58_RS06315	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS06320	COG3949	Membrane
EGX58_RS06330	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EGX58_RS06335	COG0586	Pfam SNARE associated Golgi protein
EGX58_RS06340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGX58_RS06345	COG2022	thiamine diphosphate biosynthetic process
EGX58_RS06350	COG2104	thiamine diphosphate biosynthetic process
EGX58_RS06350	COG2022	thiamine diphosphate biosynthetic process
EGX58_RS06355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGX58_RS06360	COG0352	thiamine-phosphate diphosphorylase activity
EGX58_RS06365	COG2271	Major facilitator Superfamily
EGX58_RS06380	COG4876	unkown
EGX58_RS06385	COG2357	RelA SpoT domain protein
EGX58_RS06400	COG1802	Transcriptional regulator
EGX58_RS06405	COG1070	Carbohydrate kinase
EGX58_RS06410	COG2610	gluconate transmembrane transporter activity
EGX58_RS06415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGX58_RS06420	COG0494	nUDIX hydrolase
EGX58_RS06440	COG4221	oxidoreductase activity
EGX58_RS06445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGX58_RS06450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGX58_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS06465	COG1363	Peptidase, m42
EGX58_RS06475	COG0069	glutamate synthase activity
EGX58_RS06490	COG4619	ABC transporter
EGX58_RS06495	COG0390	transport system, permease component
EGX58_RS06500	COG2814	Major facilitator Superfamily
EGX58_RS06505	COG2272	Belongs to the type-B carboxylesterase lipase family
EGX58_RS06510	COG0531	amino acid
EGX58_RS06515	COG1063	alcohol dehydrogenase
EGX58_RS06535	COG1174	glycine betaine transport
EGX58_RS06540	COG1346	cytolysis
EGX58_RS06545	COG1380	Effector of murein hydrolase LrgA
EGX58_RS06550	COG3279	Response regulator of the LytR AlgR family
EGX58_RS06555	COG3275	phosphorelay sensor kinase activity
EGX58_RS06565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGX58_RS06575	COG0706	membrane insertase activity
EGX58_RS06580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGX58_RS06585	COG0531	amino acid
EGX58_RS06590	COG0025	NhaP-type Na H and K H
EGX58_RS06595	COG1113	amino acid transport
EGX58_RS06610	COG2814	Major facilitator Superfamily
EGX58_RS06620	COG1929	Belongs to the glycerate kinase type-1 family
EGX58_RS06635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGX58_RS06640	COG1388	LysM domain
EGX58_RS06645	COG0588	phosphoglycerate mutase activity
EGX58_RS06655	COG2814	Major facilitator Superfamily
EGX58_RS06660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGX58_RS06665	COG0765	amino acid transport
EGX58_RS06670	COG1126	abc transporter atp-binding protein
EGX58_RS06675	COG2030	dehydratase
EGX58_RS06695	COG2353	YceI-like domain
EGX58_RS06720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGX58_RS06725	COG2146	nitrite reductase [NAD(P)H] activity
EGX58_RS06735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EGX58_RS06740	COG1140	nitrate reductase beta subunit
EGX58_RS06750	COG2181	nitrate reductase activity
EGX58_RS06760	COG4585	Histidine kinase
EGX58_RS06765	COG2197	response regulator
EGX58_RS06770	COG2223	nitrite transmembrane transporter activity
EGX58_RS06780	COG1846	Transcriptional regulator
EGX58_RS06815	COG1309	transcriptional regulator
EGX58_RS06860	COG0582	viral genome integration into host DNA
EGX58_RS06945	COG3728	DNA packaging
EGX58_RS06945	COG5484	DNA packaging
EGX58_RS06965	COG1511	domain protein
EGX58_RS06965	COG1196	nuclear chromosome segregation
EGX58_RS06965	COG4372	Transposase
EGX58_RS06970	COG0604	alcohol dehydrogenase
EGX58_RS06975	COG2822	iron ion transport
EGX58_RS06980	COG2837	iron assimilation
EGX58_RS06985	COG0672	)-iron permease
EGX58_RS06990	COG0805	protein transport
EGX58_RS06995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGX58_RS07010	COG1620	l-lactate permease
EGX58_RS07015	COG0438	transferase activity, transferring glycosyl groups
EGX58_RS07020	COG0579	oxidoreductase
EGX58_RS07025	COG5002	protein histidine kinase activity
EGX58_RS07025	COG3850	Histidine kinase
EGX58_RS07030	COG0745	RESPONSE REGULATOR receiver
EGX58_RS07035	COG0577	efflux transmembrane transporter activity
EGX58_RS07040	COG1136	(ABC) transporter
EGX58_RS07055	COG4640	response to antibiotic
EGX58_RS07060	COG2814	Major facilitator Superfamily
EGX58_RS07070	COG1566	PFAM secretion protein HlyD family protein
EGX58_RS07075	COG2814	Major facilitator Superfamily
EGX58_RS07085	COG0657	acetylesterase activity
EGX58_RS07100	COG0598	Magnesium transport protein CorA
EGX58_RS07105	COG1304	FMN binding
EGX58_RS07110	COG2094	Belongs to the DNA glycosylase MPG family
EGX58_RS07115	COG1742	UPF0060 membrane protein
EGX58_RS07120	COG2017	converts alpha-aldose to the beta-anomer
EGX58_RS07125	COG2258	MOSC domain
EGX58_RS07130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EGX58_RS07135	COG1266	CAAX protease self-immunity
EGX58_RS07140	COG0010	Belongs to the arginase family
EGX58_RS07145	COG1473	amidohydrolase
EGX58_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS07155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGX58_RS07170	COG1737	Transcriptional regulator
EGX58_RS07175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGX58_RS07175	COG1263	PTS System
EGX58_RS07185	COG0385	Bile acid
EGX58_RS07190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGX58_RS07210	COG1113	amino acid transport
EGX58_RS07225	COG2378	regulation of single-species biofilm formation
EGX58_RS07235	COG1316	TRANSCRIPTIONal
EGX58_RS07240	COG3383	formate dehydrogenase (NAD+) activity
EGX58_RS07265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGX58_RS07270	COG2076	Multidrug Resistance protein
EGX58_RS07275	COG2076	Multidrug Resistance protein
EGX58_RS07280	COG3942	CHAP domain
EGX58_RS07290	COG1757	Na H antiporter
EGX58_RS07295	COG3942	CHAP domain
EGX58_RS07300	COG2207	Transcriptional regulator
EGX58_RS07315	COG1960	acyl-CoA dehydrogenase activity
EGX58_RS07325	COG1268	BioY protein
EGX58_RS07335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EGX58_RS07340	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGX58_RS07345	COG4149	molybdate abc transporter
EGX58_RS07350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EGX58_RS07355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGX58_RS07360	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGX58_RS07365	COG0315	cyclic pyranopterin monophosphate synthase activity
EGX58_RS07375	COG1763	Mo-molybdopterin cofactor biosynthetic process
EGX58_RS07390	COG0746	molybdenum cofactor guanylyltransferase activity
EGX58_RS07395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGX58_RS07425	COG2348	transferase activity, transferring amino-acyl groups
EGX58_RS07430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGX58_RS07450	COG4975	Glucose uptake
EGX58_RS07455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGX58_RS07455	COG0551	DNA topoisomerase type I activity
EGX58_RS07460	COG2252	PERMEase
EGX58_RS07475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGX58_RS07480	COG0088	Forms part of the polypeptide exit tunnel
EGX58_RS07485	COG0089	rRNA binding
EGX58_RS07490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGX58_RS07495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGX58_RS07500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGX58_RS07505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGX58_RS07510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGX58_RS07520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EGX58_RS07525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGX58_RS07530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGX58_RS07535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGX58_RS07545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EGX58_RS07550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGX58_RS07555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGX58_RS07560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGX58_RS07565	COG1841	ribosomal large subunit assembly
EGX58_RS07575	COG0201	protein transport
EGX58_RS07580	COG0563	adenylate kinase activity
EGX58_RS07585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGX58_RS07590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGX58_RS07595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGX58_RS07605	COG0202	RNA polymerase activity
EGX58_RS07610	COG0203	ribosomal protein L17
EGX58_RS07615	COG1122	ATPase activity
EGX58_RS07630	COG0101	tRNA pseudouridine synthase activity
EGX58_RS07635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGX58_RS07645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGX58_RS07650	COG1349	DNA-binding transcription factor activity
EGX58_RS07655	COG0698	ribose 5-phosphate isomerase
EGX58_RS07660	COG0698	ribose 5-phosphate isomerase
EGX58_RS07665	COG1105	Belongs to the carbohydrate kinase PfkB family
EGX58_RS07670	COG3684	Belongs to the aldolase LacD family
EGX58_RS07675	COG1447	Phosphotransferase system cellobiose-specific component IIA
EGX58_RS07680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGX58_RS07680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGX58_RS07685	COG2723	6-phospho-beta-galactosidase activity
EGX58_RS07695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGX58_RS07700	COG2130	NADP-dependent
EGX58_RS07705	COG0604	alcohol dehydrogenase
EGX58_RS07710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGX58_RS07725	COG1302	Protein conserved in bacteria
EGX58_RS07730	COG4264	IucA IucC family
EGX58_RS07735	COG4264	IucA IucC family
EGX58_RS07740	COG3457	Alanine racemase
EGX58_RS07745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EGX58_RS07750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGX58_RS07755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGX58_RS07760	COG3314	Sporulation integral membrane protein YlbJ
EGX58_RS07765	COG2329	Antibiotic biosynthesis monooxygenase
EGX58_RS07770	COG1988	membrane-bound metal-dependent
EGX58_RS07775	COG4284	Utp--glucose-1-phosphate uridylyltransferase
EGX58_RS07780	COG1272	protein, Hemolysin III
EGX58_RS07795	COG0489	protein tyrosine kinase activity
EGX58_RS07845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EGX58_RS07855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGX58_RS07865	COG1119	ATPase activity
EGX58_RS07870	COG0561	phosphatase activity
EGX58_RS07890	COG0640	Transcriptional regulator
EGX58_RS07895	COG0702	epimerase
EGX58_RS07900	COG1482	cell wall glycoprotein biosynthetic process
EGX58_RS07915	COG0783	Belongs to the Dps family
EGX58_RS07920	COG0813	purine-nucleoside phosphorylase activity
EGX58_RS07925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EGX58_RS07930	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EGX58_RS07935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGX58_RS07945	COG1854	S-ribosylhomocysteine lyase activity
EGX58_RS07965	COG5146	pantothenate kinase activity
EGX58_RS07980	COG0504	CTP synthase activity
EGX58_RS07990	COG0191	fructose-bisphosphate aldolase activity
EGX58_RS07995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGX58_RS08005	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS08010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EGX58_RS08015	COG0254	rRNA binding
EGX58_RS08020	COG1435	thymidine kinase activity
EGX58_RS08025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGX58_RS08030	COG2890	protein-(glutamine-N5) methyltransferase activity
EGX58_RS08035	COG0009	L-threonylcarbamoyladenylate synthase
EGX58_RS08040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGX58_RS08045	COG4475	Protein of unknown function (DUF436)
EGX58_RS08050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGX58_RS08055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGX58_RS08060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EGX58_RS08070	COG0356	it plays a direct role in the translocation of protons across the membrane
EGX58_RS08075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGX58_RS08080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGX58_RS08085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGX58_RS08090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EGX58_RS08095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGX58_RS08100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGX58_RS08105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGX58_RS08115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGX58_RS08120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGX58_RS08130	COG0629	single-stranded DNA binding
EGX58_RS08135	COG1388	LysM domain
EGX58_RS08140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EGX58_RS08150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EGX58_RS08155	COG0352	thiamine-phosphate diphosphorylase activity
EGX58_RS08160	COG0706	membrane insertase activity
EGX58_RS08165	COG1418	mRNA catabolic process
EGX58_RS08170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGX58_RS08175	COG1937	Protein conserved in bacteria
EGX58_RS08190	COG0772	Belongs to the SEDS family
EGX58_RS08195	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGX58_RS08200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGX58_RS08205	COG0513	Belongs to the DEAD box helicase family
EGX58_RS08215	COG3428	Bacterial PH domain
EGX58_RS08225	COG0736	holo-[acyl-carrier-protein] synthase activity
EGX58_RS08230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGX58_RS08240	COG2337	Toxic component of a toxin-antitoxin (TA) module
EGX58_RS08245	COG2208	phosphoserine phosphatase activity
EGX58_RS08260	COG1191	sigma factor activity
EGX58_RS08265	COG2183	response to ionizing radiation
EGX58_RS08270	COG3091	SprT-like family
EGX58_RS08300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGX58_RS08305	COG0066	3-isopropylmalate dehydratase activity
EGX58_RS08310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGX58_RS08315	COG0473	3-isopropylmalate dehydrogenase activity
EGX58_RS08320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGX58_RS08325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGX58_RS08335	COG0028	Belongs to the TPP enzyme family
EGX58_RS08340	COG0129	dihydroxy-acid dehydratase activity
EGX58_RS08345	COG0802	atpase or kinase
EGX58_RS08350	COG1214	PFAM Peptidase M22, glycoprotease
EGX58_RS08355	COG0456	acetyltransferase
EGX58_RS08360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGX58_RS08365	COG0488	(ABC) transporter
EGX58_RS08370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EGX58_RS08375	COG2391	methyltransferase activity
EGX58_RS08380	COG0425	Belongs to the sulfur carrier protein TusA family
EGX58_RS08385	COG0004	ammonium transporteR
EGX58_RS08390	COG1621	beta-fructofuranosidase activity
EGX58_RS08395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGX58_RS08400	COG3279	Response regulator of the LytR AlgR family
EGX58_RS08415	COG4512	PFAM Accessory gene regulator B
EGX58_RS08440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGX58_RS08445	COG0459	protein refolding
EGX58_RS08455	COG0519	Catalyzes the synthesis of GMP from XMP
EGX58_RS08455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGX58_RS08470	COG1725	Transcriptional regulator
EGX58_RS08485	COG1131	(ABC) transporter
EGX58_RS08520	COG2706	6-phosphogluconolactonase activity
EGX58_RS08525	COG1012	belongs to the aldehyde dehydrogenase family
EGX58_RS08530	COG1227	inorganic diphosphatase activity
EGX58_RS08535	COG1335	isochorismatase
EGX58_RS08550	COG0077	Prephenate dehydratase
EGX58_RS08560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGX58_RS08565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGX58_RS08570	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EGX58_RS08580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EGX58_RS08585	COG4496	protein, YerC YecD
EGX58_RS08590	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EGX58_RS08595	COG0210	DNA helicase
EGX58_RS08600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGX58_RS08605	COG4851	CamS sex pheromone cAM373 precursor
EGX58_RS08610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGX58_RS08615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGX58_RS08620	COG0154	amidase activity
EGX58_RS08625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGX58_RS08630	COG1597	lipid kinase activity
EGX58_RS08635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGX58_RS08645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGX58_RS08665	COG4129	membrane
EGX58_RS08670	COG0024	Methionine aminopeptidase
EGX58_RS08675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EGX58_RS08695	COG2197	response regulator
EGX58_RS08700	COG1295	ribonuclease BN
EGX58_RS08710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGX58_RS08715	COG4840	Belongs to the UPF0435 family
EGX58_RS08720	COG2309	aminopeptidase activity
EGX58_RS08725	COG1607	acyl-coa hydrolase
EGX58_RS08730	COG0535	radical SAM domain protein
EGX58_RS08740	COG0693	protein deglycase activity
EGX58_RS08745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGX58_RS08750	COG2137	regulation of response to DNA damage stimulus
EGX58_RS08760	COG1134	teichoic acid transport
EGX58_RS08760	COG1388	LysM domain
EGX58_RS08770	COG1988	membrane-bound metal-dependent
EGX58_RS08775	COG1194	a g-specific adenine glycosylase
EGX58_RS08780	COG3557	Belongs to the UPF0374 family
EGX58_RS08790	COG4129	membrane
EGX58_RS08795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGX58_RS08800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGX58_RS08810	COG0735	belongs to the Fur family
EGX58_RS08975	COG0765	amino acid transport
EGX58_RS08980	COG1126	abc transporter atp-binding protein
EGX58_RS08985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGX58_RS08995	COG0363	glucosamine-6-phosphate deaminase activity
EGX58_RS09010	COG0114	fumarate hydratase activity
EGX58_RS09015	COG0564	pseudouridine synthase activity
EGX58_RS09020	COG2203	Gaf domain
EGX58_RS09020	COG4585	Histidine kinase
EGX58_RS09025	COG2197	response regulator
EGX58_RS09035	COG4399	Belongs to the UPF0754 family
EGX58_RS09040	COG3679	Belongs to the UPF0342 family
EGX58_RS09050	COG4717	serine-type aminopeptidase activity
EGX58_RS09060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGX58_RS09075	COG0537	adenosine 5'-monophosphoramidase activity
EGX58_RS09080	COG1131	(ABC) transporter
EGX58_RS09085	COG4473	ABC transporter
EGX58_RS09090	COG2329	Antibiotic biosynthesis monooxygenase
EGX58_RS09095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGX58_RS09100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGX58_RS09105	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EGX58_RS09155	COG0318	PFAM AMP-dependent synthetase and ligase
EGX58_RS09165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGX58_RS09170	COG0494	nUDIX hydrolase
EGX58_RS09175	COG1506	peptidase
EGX58_RS09180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EGX58_RS09185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGX58_RS09195	COG0656	L-ascorbic acid biosynthetic process
EGX58_RS09200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGX58_RS09205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGX58_RS09215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGX58_RS09240	COG5632	N-Acetylmuramoyl-L-alanine amidase
EGX58_RS09240	COG3266	domain, Protein
EGX58_RS09240	COG4193	domain, Protein
EGX58_RS09250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGX58_RS09250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGX58_RS09260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGX58_RS09260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGX58_RS09265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGX58_RS09270	COG0506	proline dehydrogenase activity
EGX58_RS09275	COG2267	carboxylic ester hydrolase activity
EGX58_RS09285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EGX58_RS09290	COG1242	4 iron, 4 sulfur cluster binding
EGX58_RS09295	COG2814	Major facilitator Superfamily
EGX58_RS09300	COG0495	leucyl-tRNA aminoacylation
EGX58_RS09320	COG2081	HI0933 family
EGX58_RS09325	COG2244	polysaccharide biosynthetic process
EGX58_RS09330	COG1187	pseudouridine synthase activity
EGX58_RS09340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGX58_RS09350	COG0510	thiamine kinase activity
EGX58_RS09355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGX58_RS09365	COG1363	Peptidase, m42
EGX58_RS09370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGX58_RS09375	COG4848	Belongs to the UPF0354 family
EGX58_RS09380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGX58_RS09385	COG1674	ftsk spoiiie
EGX58_RS09390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGX58_RS09395	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
EGX58_RS09405	COG1605	Chorismate mutase
EGX58_RS09405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EGX58_RS09410	COG1609	Transcriptional regulator
EGX58_RS09415	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EGX58_RS09430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGX58_RS09435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGX58_RS09440	COG0204	Acyl-transferase
EGX58_RS09445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGX58_RS09445	COG1263	PTS System
EGX58_RS09455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGX58_RS09465	COG1764	response to oxidative stress
EGX58_RS09470	COG0584	glycerophosphoryl diester phosphodiesterase
EGX58_RS09475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGX58_RS09485	COG1956	GAF domain-containing protein
EGX58_RS09490	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EGX58_RS09500	COG0301	tRNA thio-modification
EGX58_RS09510	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EGX58_RS09515	COG0827	DNA restriction-modification system
EGX58_RS09520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGX58_RS09525	COG0589	response to stress
EGX58_RS09530	COG0686	Belongs to the AlaDH PNT family
EGX58_RS09535	COG0006	proline dipeptidase activity
EGX58_RS09540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGX58_RS09550	COG4109	DRTGG domain
EGX58_RS09555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EGX58_RS09560	COG0587	DNA-directed DNA polymerase activity
EGX58_RS09565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGX58_RS09570	COG0825	malonyl-CoA metabolic process
EGX58_RS09575	COG0205	6-phosphofructokinase activity
EGX58_RS09580	COG0469	pyruvate kinase activity
EGX58_RS09585	COG1113	amino acid transport
EGX58_RS09590	COG0372	Belongs to the citrate synthase family
EGX58_RS09595	COG0538	isocitrate dehydrogenase activity
EGX58_RS09600	COG0745	RESPONSE REGULATOR receiver
EGX58_RS09605	COG5002	protein histidine kinase activity
EGX58_RS09610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGX58_RS09610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGX58_RS09615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGX58_RS09620	COG0237	dephospho-CoA kinase activity
EGX58_RS09630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGX58_RS09635	COG3611	Membrane attachment protein
EGX58_RS09640	COG1484	DNA-dependent DNA replication
EGX58_RS09645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGX58_RS09650	COG0833	amino acid
EGX58_RS09655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EGX58_RS09660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGX58_RS09665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGX58_RS09670	COG4112	unkown
EGX58_RS09680	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGX58_RS09685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGX58_RS09690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EGX58_RS09695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EGX58_RS09700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGX58_RS09705	COG0181	hydroxymethylbilane synthase activity
EGX58_RS09720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGX58_RS09730	COG2818	Glycosylase
EGX58_RS09735	COG0525	valine-tRNA ligase activity
EGX58_RS09740	COG0285	dihydrofolate synthase activity
EGX58_RS09750	COG2003	Belongs to the UPF0758 family
EGX58_RS09775	COG1792	Involved in formation and maintenance of cell shape
EGX58_RS09785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGX58_RS09790	COG2868	ribosomal protein
EGX58_RS09795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGX58_RS09800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGX58_RS09810	COG0632	four-way junction helicase activity
EGX58_RS09815	COG2255	four-way junction helicase activity
EGX58_RS09820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGX58_RS09830	COG1862	Preprotein translocase
EGX58_RS09835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGX58_RS09835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGX58_RS09840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EGX58_RS09840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGX58_RS09845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGX58_RS09850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGX58_RS09855	COG1490	D-aminoacyl-tRNA deacylase activity
EGX58_RS09860	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGX58_RS09865	COG0124	histidyl-tRNA synthetase
EGX58_RS09870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGX58_RS09880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGX58_RS09885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGX58_RS09890	COG1959	2 iron, 2 sulfur cluster binding
EGX58_RS09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGX58_RS09905	COG1104	cysteine desulfurase activity
EGX58_RS09910	COG0482	sulfurtransferase activity
EGX58_RS09920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGX58_RS09925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGX58_RS09930	COG4472	Bacterial protein of unknown function (DUF965)
EGX58_RS09935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGX58_RS09940	COG3906	Belongs to the UPF0473 family
EGX58_RS09950	COG0826	peptidase U32
EGX58_RS09955	COG0826	peptidase U32
EGX58_RS09960	COG0572	uridine kinase
EGX58_RS09965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGX58_RS09970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EGX58_RS09975	COG1984	allophanate hydrolase subunit 2
EGX58_RS09985	COG0439	Biotin carboxylase
EGX58_RS09990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EGX58_RS09995	COG1914	H( )-stimulated, divalent metal cation uptake system
EGX58_RS10000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGX58_RS10005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EGX58_RS10010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EGX58_RS10015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGX58_RS10020	COG1534	Rna-binding protein
EGX58_RS10025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGX58_RS10030	COG1713	HD superfamily hydrolase involved in NAD metabolism
EGX58_RS10035	COG0799	negative regulation of ribosome biogenesis
EGX58_RS10040	COG2226	methyltransferase
EGX58_RS10050	COG2131	deaminase
EGX58_RS10055	COG0658	competence protein
EGX58_RS10055	COG2333	competence protein COMEC
EGX58_RS10060	COG1466	dna polymerase III delta subunit
EGX58_RS10065	COG0268	Binds directly to 16S ribosomal RNA
EGX58_RS10070	COG0481	GTPase activity
EGX58_RS10075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGX58_RS10080	COG1420	regulation of RNA biosynthetic process
EGX58_RS10085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGX58_RS10090	COG0443	Heat shock 70 kDa protein
EGX58_RS10095	COG0484	heat shock protein binding
EGX58_RS10100	COG2264	protein methyltransferase activity
EGX58_RS10105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGX58_RS10110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGX58_RS10120	COG1030	water channel activity
EGX58_RS10125	COG4864	UPF0365 protein
EGX58_RS10135	COG1702	phosphate starvation-inducible protein PhoH
EGX58_RS10145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EGX58_RS10150	COG0295	cytidine deaminase activity
EGX58_RS10155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGX58_RS10160	COG1381	Involved in DNA repair and RecF pathway recombination
EGX58_RS10165	COG0423	glycine-tRNA ligase activity
EGX58_RS10170	COG0517	IMP dehydrogenase activity
EGX58_RS10175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGX58_RS10180	COG0358	DNA primase activity
EGX58_RS10185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGX58_RS10190	COG2384	SAM-dependent methyltransferase
EGX58_RS10195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGX58_RS10200	COG0513	Belongs to the DEAD box helicase family
EGX58_RS10205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EGX58_RS10210	COG1121	(ABC) transporter
EGX58_RS10215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGX58_RS10225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGX58_RS10230	COG0768	penicillin binding
EGX58_RS10240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGX58_RS10250	COG4483	Protein conserved in bacteria
EGX58_RS10255	COG1940	carbohydrate kinase activity
EGX58_RS10260	COG0011	TIGRFAM Protein of
EGX58_RS10265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGX58_RS10270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGX58_RS10275	COG1459	type II secretion system
EGX58_RS10280	COG4537	Required for transformation and DNA binding
EGX58_RS10300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGX58_RS10305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EGX58_RS10310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGX58_RS10315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGX58_RS10320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGX58_RS10325	COG0095	Lipoate-protein ligase
EGX58_RS10340	COG0006	proline dipeptidase activity
EGX58_RS10345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGX58_RS10350	COG0511	ligase activity, forming carbon-carbon bonds
EGX58_RS10355	COG0439	Biotin carboxylase
EGX58_RS10360	COG1302	Protein conserved in bacteria
EGX58_RS10365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGX58_RS10370	COG1570	exodeoxyribonuclease VII activity
EGX58_RS10380	COG0142	geranyltranstransferase activity
EGX58_RS10385	COG1438	arginine binding
EGX58_RS10390	COG0497	DNA recombination
EGX58_RS10395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGX58_RS10400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGX58_RS10405	COG0022	dehydrogenase e1 component
EGX58_RS10410	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGX58_RS10420	COG4129	membrane
EGX58_RS10425	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGX58_RS10435	COG0366	Alpha amylase catalytic
EGX58_RS10445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGX58_RS10450	COG1234	tRNA 3'-trailer cleavage
EGX58_RS10455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EGX58_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
EGX58_RS10465	COG0667	Aldo Keto reductase
EGX58_RS10470	COG0494	nUDIX hydrolase
EGX58_RS10475	COG0735	belongs to the Fur family
EGX58_RS10480	COG4974	Belongs to the 'phage' integrase family
EGX58_RS10490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGX58_RS10495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGX58_RS10500	COG1187	pseudouridine synthase activity
EGX58_RS10505	COG0745	RESPONSE REGULATOR receiver
EGX58_RS10510	COG5002	protein histidine kinase activity
EGX58_RS10520	COG1141	Ferredoxin
EGX58_RS10530	COG0514	ATP-dependent DNA helicase (RecQ)
EGX58_RS10535	COG1388	LysM domain
EGX58_RS10535	COG1388	LysM domain
EGX58_RS10540	COG0492	ferredoxin-NADP+ reductase activity
EGX58_RS10550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGX58_RS10555	COG0539	negative regulation of cytoplasmic translation
EGX58_RS10560	COG1160	GTP binding
EGX58_RS10565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGX58_RS10580	COG2226	methyltransferase
EGX58_RS10585	COG0142	geranyltranstransferase activity
EGX58_RS10590	COG0105	UTP biosynthetic process
EGX58_RS10595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGX58_RS10600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGX58_RS10605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGX58_RS10610	COG0457	Tetratricopeptide repeat
EGX58_RS10615	COG5582	Belongs to the UPF0302 family
EGX58_RS10625	COG2738	Putative neutral zinc metallopeptidase
EGX58_RS10630	COG1694	Mazg nucleotide pyrophosphohydrolase
EGX58_RS10635	COG0438	transferase activity, transferring glycosyl groups
EGX58_RS10640	COG0617	tRNA 3'-terminal CCA addition
EGX58_RS10650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGX58_RS10650	COG1199	ATP-dependent helicase activity
EGX58_RS10655	COG0017	Asparaginyl-tRNA synthetase
EGX58_RS10660	COG3935	DnaD domain protein
EGX58_RS10665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGX58_RS10675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGX58_RS10675	COG4499	WXG100 protein secretion system (Wss), protein YukC
EGX58_RS10680	COG3331	DNA recombination
EGX58_RS10690	COG4474	Belongs to the UPF0398 family
EGX58_RS10695	COG3599	regulation of cell shape
EGX58_RS10705	COG0116	Belongs to the methyltransferase superfamily
EGX58_RS10715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EGX58_RS10720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGX58_RS10725	COG0328	RNA-DNA hybrid ribonuclease activity
EGX58_RS10730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EGX58_RS10740	COG1413	lyase activity
EGX58_RS10745	COG1413	lyase activity
EGX58_RS10775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGX58_RS10780	COG2190	(PTS) system
EGX58_RS10785	COG4479	Belongs to the UPF0346 family
EGX58_RS10790	COG0793	Belongs to the peptidase S41A family
EGX58_RS10800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGX58_RS10805	COG0671	phosphoesterase, PA-phosphatase related
EGX58_RS10810	COG0745	RESPONSE REGULATOR receiver
EGX58_RS10815	COG5002	protein histidine kinase activity
EGX58_RS10820	COG0567	Dehydrogenase, E1 component
EGX58_RS10840	COG0714	Associated with various cellular activities
EGX58_RS10845	COG4548	von Willebrand factor, type A
EGX58_RS10850	COG1114	Component of the transport system for branched-chain amino acids
EGX58_RS10855	COG3853	Toxic anion resistance protein (TelA)
EGX58_RS10865	COG1254	Belongs to the acylphosphatase family
EGX58_RS10875	COG1278	Cold shock
EGX58_RS10890	COG1473	amidohydrolase
EGX58_RS10895	COG2171	N-acyltransferase activity
EGX58_RS10900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGX58_RS10905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGX58_RS10910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGX58_RS10920	COG0488	(ABC) transporter
EGX58_RS10925	COG2996	Protein conserved in bacteria
EGX58_RS10930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EGX58_RS10935	COG0573	inorganic phosphate transmembrane transporter activity
EGX58_RS10940	COG0581	inorganic phosphate transmembrane transporter activity
EGX58_RS10945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGX58_RS10950	COG0704	Plays a role in the regulation of phosphate uptake
EGX58_RS10965	COG4607	ABC-type enterochelin transport system periplasmic component
EGX58_RS10975	COG2348	transferase activity, transferring amino-acyl groups
EGX58_RS10980	COG0159	tryptophan synthase activity
EGX58_RS10990	COG0135	phosphoribosylanthranilate isomerase activity
EGX58_RS10995	COG0134	indole-3-glycerol-phosphate synthase activity
EGX58_RS11000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGX58_RS11005	COG0512	Glutamine amidotransferase of anthranilate synthase
EGX58_RS11010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGX58_RS11015	COG1363	Peptidase, m42
EGX58_RS11020	COG0287	Prephenate dehydrogenase
EGX58_RS11025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGX58_RS11030	COG1942	4-Oxalocrotonate Tautomerase
EGX58_RS11045	COG0392	lysyltransferase activity
EGX58_RS11045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EGX58_RS11050	COG0628	permease
EGX58_RS11055	COG3711	transcriptional antiterminator
EGX58_RS11060	COG1115	amino acid carrier protein
EGX58_RS11065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGX58_RS11070	COG0187	DNA topoisomerase II activity
EGX58_RS11075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGX58_RS11080	COG4841	protein insertion into membrane
EGX58_RS11085	COG0824	Thioesterase
EGX58_RS11090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EGX58_RS11095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGX58_RS11100	COG1970	mechanosensitive ion channel activity
EGX58_RS11110	COG0419	ATPase involved in DNA repair
EGX58_RS11115	COG0420	3'-5' exonuclease activity
EGX58_RS11120	COG4846	Membrane protein involved in cytochrome C biogenesis
EGX58_RS11125	COG3763	UPF0154 protein
EGX58_RS11135	COG4224	UPF0291 protein
EGX58_RS11145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGX58_RS11160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGX58_RS11170	COG0833	amino acid
EGX58_RS11190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EGX58_RS11195	COG0460	homoserine dehydrogenase
EGX58_RS11200	COG0527	aspartate kinase activity