locus-tag	class	description
FOC54_RS00020	COG3279	Response regulator of the LytR AlgR family
FOC54_RS00070	COG1192	Involved in chromosome partitioning
FOC54_RS00135	COG0640	Transcriptional regulator
FOC54_RS00160	COG1511	domain protein
FOC54_RS00220	COG0589	response to stress
FOC54_RS00225	COG0659	secondary active sulfate transmembrane transporter activity
FOC54_RS00255	COG0456	acetyltransferase
FOC54_RS00295	COG0420	3'-5' exonuclease activity
FOC54_RS00300	COG4846	Membrane protein involved in cytochrome C biogenesis
FOC54_RS00305	COG3763	UPF0154 protein
FOC54_RS00315	COG4224	UPF0291 protein
FOC54_RS00330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FOC54_RS00345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC54_RS00355	COG0833	amino acid
FOC54_RS00370	COG0083	homoserine kinase activity
FOC54_RS00375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FOC54_RS00380	COG0460	homoserine dehydrogenase
FOC54_RS00385	COG0527	aspartate kinase activity
FOC54_RS00410	COG2197	response regulator
FOC54_RS00415	COG4585	Histidine kinase
FOC54_RS00425	COG1131	(ABC) transporter
FOC54_RS00430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC54_RS00460	COG4824	toxin secretion phage lysis holin
FOC54_RS00495	COG5412	phage tail tape measure protein
FOC54_RS00495	COG3953	SLT domain
FOC54_RS00540	COG0740	serine-type endopeptidase activity
FOC54_RS00685	COG0789	Transcriptional regulator
FOC54_RS00695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FOC54_RS00700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOC54_RS00705	COG0386	Belongs to the glutathione peroxidase family
FOC54_RS00710	COG1923	regulation of RNA biosynthetic process
FOC54_RS00715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOC54_RS00725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOC54_RS00730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FOC54_RS00735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FOC54_RS00740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FOC54_RS00745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FOC54_RS00750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC54_RS00765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC54_RS00775	COG4195	phage-related replication protein
FOC54_RS00780	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOC54_RS00785	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOC54_RS00785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOC54_RS00790	COG1692	metallophosphoesterase
FOC54_RS00800	COG1418	mRNA catabolic process
FOC54_RS00805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOC54_RS00810	COG1058	Belongs to the CinA family
FOC54_RS00810	COG1546	Belongs to the CinA family
FOC54_RS00830	COG0300	oxidoreductase activity
FOC54_RS00835	COG0612	Peptidase, M16
FOC54_RS00840	COG0612	Peptidase, M16
FOC54_RS00845	COG2188	Transcriptional regulator
FOC54_RS00850	COG1674	ftsk spoiiie
FOC54_RS00855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC54_RS00860	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC54_RS00865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOC54_RS00870	COG0196	riboflavin kinase activity
FOC54_RS00875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOC54_RS00880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOC54_RS00885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOC54_RS00895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FOC54_RS00900	COG0195	Participates in both transcription termination and antitermination
FOC54_RS00905	COG0779	Required for maturation of 30S ribosomal subunits
FOC54_RS00910	COG2176	DNA-directed DNA polymerase activity
FOC54_RS00915	COG0442	prolyl-tRNA aminoacylation
FOC54_RS00925	COG4589	Belongs to the CDS family
FOC54_RS00930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOC54_RS00935	COG0233	cytoplasmic translational termination
FOC54_RS00940	COG0528	UMP kinase activity
FOC54_RS00945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOC54_RS00950	COG0052	Belongs to the universal ribosomal protein uS2 family
FOC54_RS00955	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FOC54_RS00960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FOC54_RS00965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FOC54_RS00970	COG4974	Belongs to the 'phage' integrase family
FOC54_RS00975	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FOC54_RS00980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC54_RS00985	COG0758	DNA mediated transformation
FOC54_RS00990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC54_RS00995	COG0045	succinate-CoA ligase (ADP-forming) activity
FOC54_RS01000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC54_RS01010	COG4485	Bacterial membrane protein, YfhO
FOC54_RS01025	COG0335	large ribosomal subunit rRNA binding
FOC54_RS01030	COG0336	Belongs to the RNA methyltransferase TrmD family
FOC54_RS01035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOC54_RS01040	COG0228	four-way junction DNA binding
FOC54_RS01045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC54_RS01050	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FOC54_RS01055	COG0552	protein localization to endoplasmic reticulum
FOC54_RS01060	COG1196	nuclear chromosome segregation
FOC54_RS01065	COG0571	ribonuclease III activity
FOC54_RS01070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC54_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS01085	COG0416	fatty acid biosynthetic process
FOC54_RS01090	COG1349	DNA-binding transcription factor activity
FOC54_RS01100	COG1461	Dihydroxyacetone kinase
FOC54_RS01105	COG1302	Protein conserved in bacteria
FOC54_RS01110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOC54_RS01115	COG1564	THIamine pyrophosphokinase
FOC54_RS01120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC54_RS01125	COG1162	GTPase activity
FOC54_RS01135	COG0631	protein serine/threonine phosphatase activity
FOC54_RS01140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOC54_RS01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC54_RS01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOC54_RS01150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOC54_RS01160	COG2314	TM2 domain
FOC54_RS01165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC54_RS01170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOC54_RS01175	COG1758	RNA polymerase activity
FOC54_RS01180	COG0194	GDP metabolic process
FOC54_RS01185	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FOC54_RS01200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOC54_RS01205	COG0284	orotidine-5'-phosphate decarboxylase activity
FOC54_RS01210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOC54_RS01215	COG0505	Belongs to the CarA family
FOC54_RS01225	COG0540	Belongs to the ATCase OTCase family
FOC54_RS01230	COG2233	PERMEase
FOC54_RS01235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOC54_RS01240	COG0564	pseudouridine synthase activity
FOC54_RS01245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC54_RS01250	COG1388	LysM domain
FOC54_RS01250	COG3942	CHAP domain
FOC54_RS01260	COG0702	epimerase
FOC54_RS01265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC54_RS01270	COG3599	regulation of cell shape
FOC54_RS01280	COG0762	integral membrane protein
FOC54_RS01285	COG1799	cell septum assembly
FOC54_RS01290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC54_RS01295	COG1496	oxidoreductase activity
FOC54_RS01300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC54_RS01305	COG0849	cell division
FOC54_RS01310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FOC54_RS01315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC54_RS01320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC54_RS01325	COG0768	penicillin binding
FOC54_RS01330	COG4839	cell division protein FtsL
FOC54_RS01335	COG0275	rRNA processing
FOC54_RS01340	COG2001	Belongs to the MraZ family
FOC54_RS01345	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FOC54_RS01350	COG1011	Hydrolase
FOC54_RS01380	COG1525	nuclease
FOC54_RS01450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOC54_RS01455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC54_RS01460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOC54_RS01465	COG1053	succinate dehydrogenase
FOC54_RS01470	COG2009	succinate dehydrogenase
FOC54_RS01475	COG0322	excinuclease ABC activity
FOC54_RS01480	COG3118	belongs to the thioredoxin family
FOC54_RS01485	COG1193	negative regulation of DNA recombination
FOC54_RS01490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FOC54_RS01490	COG1796	DNA polymerase
FOC54_RS01505	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC54_RS01515	COG0072	phenylalanine-tRNA ligase activity
FOC54_RS01515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC54_RS01520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOC54_RS01525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC54_RS01530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOC54_RS01540	COG1323	Belongs to the UPF0348 family
FOC54_RS01545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOC54_RS01550	COG0742	ribosomal rna small subunit methyltransferase
FOC54_RS01565	COG0584	glycerophosphoryl diester phosphodiesterase
FOC54_RS01570	COG3679	Belongs to the UPF0342 family
FOC54_RS01585	COG0109	protoheme IX farnesyltransferase activity
FOC54_RS01590	COG1612	heme a metabolic process
FOC54_RS01600	COG0772	Belongs to the SEDS family
FOC54_RS01605	COG4838	Belongs to the UPF0358 family
FOC54_RS01610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOC54_RS01625	COG1217	gtp-binding protein TYPA
FOC54_RS01635	COG0483	inositol monophosphate 1-phosphatase activity
FOC54_RS01645	COG4493	Belongs to the UPF0637 family
FOC54_RS01650	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC54_RS01660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FOC54_RS01670	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOC54_RS01675	COG3842	ATPase activity
FOC54_RS01680	COG3800	Transcriptional regulator
FOC54_RS01680	COG1396	sequence-specific DNA binding
FOC54_RS01685	COG4476	Belongs to the UPF0223 family
FOC54_RS01695	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC54_RS01715	COG0242	peptide deformylase activity
FOC54_RS01720	COG5503	Protein of unknown function (DUF1447)
FOC54_RS01725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC54_RS01730	COG0569	domain protein
FOC54_RS01735	COG1294	oxidase, subunit
FOC54_RS01740	COG1271	oxidase subunit
FOC54_RS01750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOC54_RS01765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC54_RS01780	COG4172	Belongs to the ABC transporter superfamily
FOC54_RS01785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOC54_RS01790	COG0151	Belongs to the GarS family
FOC54_RS01795	COG0138	bifunctional purine biosynthesis protein purh
FOC54_RS01805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOC54_RS01815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC54_RS01820	COG0047	phosphoribosylformylglycinamidine synthase activity
FOC54_RS01825	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC54_RS01830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOC54_RS01835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FOC54_RS01840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC54_RS01845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOC54_RS01850	COG1017	nitric oxide dioxygenase activity
FOC54_RS01850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOC54_RS01860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOC54_RS01865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOC54_RS01870	COG1845	cytochrome c oxidase, subunit III
FOC54_RS01875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FOC54_RS01890	COG1316	TRANSCRIPTIONal
FOC54_RS01905	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC54_RS01905	COG4193	domain, Protein
FOC54_RS01905	COG3266	domain, Protein
FOC54_RS01915	COG0436	Aminotransferase
FOC54_RS01920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOC54_RS01930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOC54_RS01935	COG1169	isochorismate synthase
FOC54_RS01940	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC54_RS01950	COG2314	TM2 domain
FOC54_RS02015	COG4824	toxin secretion phage lysis holin
FOC54_RS02105	COG3728	DNA packaging
FOC54_RS02105	COG5484	DNA packaging
FOC54_RS02115	COG3331	DNA recombination
FOC54_RS02250	COG4873	Protein conserved in bacteria
FOC54_RS02260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC54_RS02265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC54_RS02265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC54_RS02270	COG0861	Integral membrane protein TerC family
FOC54_RS02275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOC54_RS02285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC54_RS02290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC54_RS02295	COG2814	Major facilitator Superfamily
FOC54_RS02300	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOC54_RS02305	COG2382	esterase
FOC54_RS02310	COG0628	permease
FOC54_RS02320	COG0475	glutathione-regulated potassium exporter activity
FOC54_RS02320	COG0569	domain protein
FOC54_RS02325	COG2239	Acts as a magnesium transporter
FOC54_RS02330	COG0564	pseudouridine synthase activity
FOC54_RS02335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC54_RS02340	COG2357	RelA SpoT domain protein
FOC54_RS02355	COG2346	COG2346, Truncated hemoglobins
FOC54_RS02360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOC54_RS02365	COG1164	Oligoendopeptidase f
FOC54_RS02375	COG4862	establishment of competence for transformation
FOC54_RS02380	COG1393	Belongs to the ArsC family
FOC54_RS02385	COG0180	Tryptophanyl-tRNA synthetase
FOC54_RS02390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC54_RS02395	COG0601	transmembrane transport
FOC54_RS02400	COG4608	Belongs to the ABC transporter superfamily
FOC54_RS02405	COG0444	Belongs to the ABC transporter superfamily
FOC54_RS02415	COG4166	transmembrane transport
FOC54_RS02420	COG4608	Belongs to the ABC transporter superfamily
FOC54_RS02425	COG0444	Belongs to the ABC transporter superfamily
FOC54_RS02430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC54_RS02435	COG0601	transmembrane transport
FOC54_RS02450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC54_RS02460	COG0542	response to heat
FOC54_RS02475	COG0561	phosphatase activity
FOC54_RS02480	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC54_RS02495	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC54_RS02500	COG1074	ATP-dependent DNA helicase activity
FOC54_RS02505	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FOC54_RS02520	COG0398	Pfam SNARE associated Golgi protein
FOC54_RS02525	COG0166	Belongs to the GPI family
FOC54_RS02530	COG0137	argininosuccinate synthase activity
FOC54_RS02535	COG0165	Argininosuccinate lyase
FOC54_RS02540	COG0584	glycerophosphoryl diester phosphodiesterase
FOC54_RS02555	COG1902	pentaerythritol trinitrate reductase activity
FOC54_RS02560	COG1098	S1 RNA binding domain
FOC54_RS02565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC54_RS02575	COG2111	Na H antiporter
FOC54_RS02575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC54_RS02580	COG2111	Na H antiporter
FOC54_RS02585	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC54_RS02590	COG0651	ATP synthesis coupled electron transport
FOC54_RS02595	COG1863	multisubunit Na H antiporter MnhE subunit
FOC54_RS02600	COG2212	antiporter activity
FOC54_RS02605	COG1320	monovalent cation:proton antiporter activity
FOC54_RS02615	COG2050	protein possibly involved in aromatic compounds catabolism
FOC54_RS02620	COG2056	Na+-H+ antiporter family
FOC54_RS02625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOC54_RS02630	COG1252	NADH dehydrogenase
FOC54_RS02635	COG0316	Belongs to the HesB IscA family
FOC54_RS02640	COG4844	belongs to the
FOC54_RS02645	COG1252	NADH dehydrogenase
FOC54_RS02650	COG4837	Protein of unknown function (DUF1462)
FOC54_RS02655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC54_RS02660	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FOC54_RS02665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC54_RS02670	COG1696	Membrane protein involved in D-alanine export
FOC54_RS02675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOC54_RS02685	COG0647	UMP catabolic process
FOC54_RS02690	COG2445	Protein of unknown function DUF86
FOC54_RS02700	COG4470	Protein conserved in bacteria
FOC54_RS02705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOC54_RS02710	COG0737	Belongs to the 5'-nucleotidase family
FOC54_RS02715	COG0730	response to heat
FOC54_RS02720	COG1801	Protein of unknown function DUF72
FOC54_RS02725	COG0719	Fe-S assembly protein
FOC54_RS02730	COG0822	iron-sulfur transferase activity
FOC54_RS02735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC54_RS02740	COG0719	Fe-S assembly protein
FOC54_RS02745	COG0396	ATPase activity
FOC54_RS02755	COG3237	CsbD-like
FOC54_RS02760	COG1464	Belongs to the NlpA lipoprotein family
FOC54_RS02765	COG2011	ABC-type metal ion transport system permease component
FOC54_RS02770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC54_RS02780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC54_RS02785	COG0509	glycine decarboxylation via glycine cleavage system
FOC54_RS02790	COG1393	Belongs to the ArsC family
FOC54_RS02795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC54_RS02805	COG0710	3-dehydroquinate dehydratase activity
FOC54_RS02810	COG1764	response to oxidative stress
FOC54_RS02850	COG4195	phage-related replication protein
FOC54_RS02880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOC54_RS02885	COG0557	exoribonuclease II activity
FOC54_RS02890	COG1647	Serine aminopeptidase, S33
FOC54_RS02895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC54_RS02905	COG0148	phosphopyruvate hydratase activity
FOC54_RS02910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FOC54_RS02915	COG0149	triose-phosphate isomerase activity
FOC54_RS02920	COG0126	phosphoglycerate kinase activity
FOC54_RS02930	COG2390	Transcriptional regulator
FOC54_RS02945	COG1090	epimerase
FOC54_RS02955	COG0740	serine-type endopeptidase activity
FOC54_RS02965	COG1481	regulation of sporulation
FOC54_RS02970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOC54_RS02975	COG1660	Displays ATPase and GTPase activities
FOC54_RS02990	COG0110	maltose O-acetyltransferase activity
FOC54_RS02995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FOC54_RS03000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FOC54_RS03005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC54_RS03010	COG0556	nucleotide-excision repair
FOC54_RS03025	COG3942	CHAP domain
FOC54_RS03025	COG1388	LysM domain
FOC54_RS03035	COG0653	protein targeting
FOC54_RS03040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOC54_RS03045	COG1040	competence protein
FOC54_RS03050	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FOC54_RS03060	COG1739	Uncharacterized protein family UPF0029
FOC54_RS03065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC54_RS03070	COG2199	diguanylate cyclase activity
FOC54_RS03085	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC54_RS03095	COG1929	Belongs to the glycerate kinase type-1 family
FOC54_RS03100	COG3118	belongs to the thioredoxin family
FOC54_RS03115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC54_RS03125	COG4607	ABC-type enterochelin transport system periplasmic component
FOC54_RS03130	COG4604	ABC transporter, ATP-binding protein
FOC54_RS03135	COG4605	iron ion homeostasis
FOC54_RS03140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC54_RS03145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC54_RS03150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC54_RS03155	COG1780	Probably involved in ribonucleotide reductase function
FOC54_RS03165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FOC54_RS03170	COG3104	oligopeptide transport
FOC54_RS03175	COG1597	lipid kinase activity
FOC54_RS03185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOC54_RS03190	COG1174	glycine betaine transport
FOC54_RS03195	COG0517	IMP dehydrogenase activity
FOC54_RS03195	COG1125	glycine betaine transport
FOC54_RS03200	COG0514	ATP-dependent DNA helicase (RecQ)
FOC54_RS03205	COG0488	(ABC) transporter
FOC54_RS03215	COG1368	sulfuric ester hydrolase activity
FOC54_RS03240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC54_RS03245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC54_RS03245	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC54_RS03250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FOC54_RS03255	COG0720	synthase
FOC54_RS03260	COG0602	queuosine metabolic process
FOC54_RS03270	COG0463	Glycosyl transferase, family 2
FOC54_RS03275	COG0656	L-ascorbic acid biosynthetic process
FOC54_RS03280	COG1253	flavin adenine dinucleotide binding
FOC54_RS03285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC54_RS03285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC54_RS03285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC54_RS03290	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC54_RS03295	COG1349	DNA-binding transcription factor activity
FOC54_RS03300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOC54_RS03320	COG0415	Belongs to the DNA photolyase family
FOC54_RS03330	COG0523	cobalamin synthesis protein
FOC54_RS03340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FOC54_RS03345	COG4988	ABC transporter
FOC54_RS03350	COG1968	undecaprenyl-diphosphatase activity
FOC54_RS03360	COG1671	Belongs to the UPF0178 family
FOC54_RS03365	COG1611	Belongs to the LOG family
FOC54_RS03400	COG0583	DNA-binding transcription factor activity
FOC54_RS03410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC54_RS03420	COG0217	transcriptional regulatory protein
FOC54_RS03430	COG0662	Cupin 2, conserved barrel domain protein
FOC54_RS03430	COG2207	Transcriptional regulator
FOC54_RS03440	COG1388	LysM domain
FOC54_RS03440	COG3942	CHAP domain
FOC54_RS03445	COG0306	phosphate transporter
FOC54_RS03450	COG1392	Phosphate transport regulator
FOC54_RS03455	COG0577	efflux transmembrane transporter activity
FOC54_RS03460	COG1136	(ABC) transporter
FOC54_RS03465	COG2205	protein histidine kinase activity
FOC54_RS03470	COG0745	RESPONSE REGULATOR receiver
FOC54_RS03475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC54_RS03485	COG3949	Membrane
FOC54_RS03495	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FOC54_RS03500	COG1120	ATPase activity
FOC54_RS03505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC54_RS03510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC54_RS03515	COG0463	Glycosyl transferase, family 2
FOC54_RS03515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC54_RS03520	COG1132	(ABC) transporter
FOC54_RS03525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOC54_RS03535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC54_RS03540	COG1682	transport, permease protein
FOC54_RS03545	COG1134	teichoic acid transport
FOC54_RS03550	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FOC54_RS03565	COG0025	NhaP-type Na H and K H
FOC54_RS03570	COG1320	monovalent cation:proton antiporter activity
FOC54_RS03575	COG2212	antiporter activity
FOC54_RS03580	COG1863	multisubunit Na H antiporter MnhE subunit
FOC54_RS03585	COG0651	ATP synthesis coupled electron transport
FOC54_RS03590	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC54_RS03595	COG2111	Na H antiporter
FOC54_RS03600	COG2111	Na H antiporter
FOC54_RS03600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC54_RS03605	COG4974	Belongs to the 'phage' integrase family
FOC54_RS03655	COG0546	phosphoglycolate phosphatase activity
FOC54_RS03660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC54_RS03665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC54_RS03675	COG0789	Transcriptional regulator
FOC54_RS03675	COG4978	Transcriptional regulator
FOC54_RS03685	COG0018	arginyl-trna synthetase
FOC54_RS03700	COG3875	lactate racemase activity
FOC54_RS03705	COG1606	tRNA processing
FOC54_RS03710	COG1691	(AIR) carboxylase
FOC54_RS03715	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FOC54_RS03725	COG1078	dGTPase activity
FOC54_RS03735	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOC54_RS03740	COG0667	Aldo Keto reductase
FOC54_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC54_RS03755	COG4844	belongs to the
FOC54_RS03775	COG0095	Lipoate-protein ligase
FOC54_RS03785	COG3253	May function as heme-dependent peroxidase
FOC54_RS03800	COG0531	amino acid
FOC54_RS03805	COG2363	Small membrane protein
FOC54_RS03815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOC54_RS03840	COG0183	Belongs to the thiolase family
FOC54_RS03845	COG0318	PFAM AMP-dependent synthetase and ligase
FOC54_RS03850	COG2843	Capsule synthesis protein
FOC54_RS03855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FOC54_RS03860	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FOC54_RS03870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC54_RS03875	COG1469	GTP cyclohydrolase I activity
FOC54_RS03895	COG0431	NADPH-dependent FMN reductase
FOC54_RS03900	COG0561	phosphatase activity
FOC54_RS03910	COG1428	Deoxynucleoside kinase
FOC54_RS03915	COG1428	Deoxynucleoside kinase
FOC54_RS03920	COG0546	phosphoglycolate phosphatase activity
FOC54_RS04045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC54_RS04050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC54_RS04055	COG0737	Belongs to the 5'-nucleotidase family
FOC54_RS04065	COG0494	nUDIX hydrolase
FOC54_RS04080	COG1473	amidohydrolase
FOC54_RS04085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOC54_RS04090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOC54_RS04100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOC54_RS04110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOC54_RS04115	COG0085	RNA polymerase activity
FOC54_RS04120	COG2813	Specifically methylates the guanine in position
FOC54_RS04130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOC54_RS04140	COG0081	regulation of translation
FOC54_RS04145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOC54_RS04150	COG0250	Participates in transcription elongation, termination and antitermination
FOC54_RS04155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC54_RS04160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC54_RS04170	COG3688	RNA-binding protein containing a PIN domain
FOC54_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC54_RS04180	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FOC54_RS04185	COG0215	cysteine-tRNA ligase activity
FOC54_RS04190	COG1045	serine acetyltransferase
FOC54_RS04195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC54_RS04200	COG4956	integral membrane protein (PIN domain superfamily)
FOC54_RS04205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC54_RS04210	COG0542	response to heat
FOC54_RS04215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FOC54_RS04220	COG3880	PFAM UvrB UvrC protein
FOC54_RS04225	COG4463	regulation of RNA biosynthetic process
FOC54_RS04230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC54_RS04235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FOC54_RS04240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FOC54_RS04245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC54_RS04330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOC54_RS04335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC54_RS04350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC54_RS04355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FOC54_RS04360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC54_RS04375	COG1098	S1 RNA binding domain
FOC54_RS04385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FOC54_RS04390	COG3956	TIGRFAM MazG family protein
FOC54_RS04395	COG2244	polysaccharide biosynthetic process
FOC54_RS04400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC54_RS04405	COG0193	aminoacyl-tRNA hydrolase activity
FOC54_RS04410	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOC54_RS04415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC54_RS04420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOC54_RS04425	COG2088	sporulation resulting in formation of a cellular spore
FOC54_RS04430	COG0251	oxidation-reduction process
FOC54_RS04435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC54_RS04440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FOC54_RS04445	COG4466	Protein conserved in bacteria
FOC54_RS04450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOC54_RS04455	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC54_RS04460	COG0084	hydrolase, TatD family'
FOC54_RS04465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC54_RS04465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC54_RS04470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC54_RS04475	COG2827	Endonuclease containing a URI domain
FOC54_RS04480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FOC54_RS04485	COG4467	Involved in initiation control of chromosome replication
FOC54_RS04490	COG1774	PSP1 C-terminal conserved region
FOC54_RS04495	COG0470	DNA polymerase III
FOC54_RS04500	COG3870	Protein conserved in bacteria
FOC54_RS04505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOC54_RS04510	COG1982	Orn Lys Arg decarboxylase major
FOC54_RS04530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOC54_RS04540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC54_RS04560	COG0493	'glutamate synthase
FOC54_RS04565	COG0070	glutamate synthase
FOC54_RS04565	COG0069	glutamate synthase activity
FOC54_RS04565	COG0067	glutamate synthase
FOC54_RS04585	COG0494	nUDIX hydrolase
FOC54_RS04595	COG1388	LysM domain
FOC54_RS04595	COG3942	CHAP domain
FOC54_RS04605	COG2011	ABC-type metal ion transport system permease component
FOC54_RS04610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC54_RS04615	COG0626	cystathionine gamma-synthase activity
FOC54_RS04620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC54_RS04630	COG0733	neurotransmitter:sodium symporter activity
FOC54_RS04640	COG1647	Serine aminopeptidase, S33
FOC54_RS04645	COG0671	phosphoesterase, PA-phosphatase related
FOC54_RS04650	COG5609	conserved protein (DUF2294)
FOC54_RS04655	COG3002	Belongs to the UPF0753 family
FOC54_RS04660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC54_RS04670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOC54_RS04670	COG0519	Catalyzes the synthesis of GMP from XMP
FOC54_RS04675	COG0516	GMP reductase activity
FOC54_RS04675	COG0517	IMP dehydrogenase activity
FOC54_RS04680	COG2233	PERMEase
FOC54_RS04685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC54_RS04700	COG5183	chlorophyll binding
FOC54_RS04705	COG1823	symporter activity
FOC54_RS04710	COG0778	Nitroreductase
FOC54_RS04720	COG0450	alkyl hydroperoxide reductase
FOC54_RS04725	COG3634	alkyl hydroperoxide reductase activity
FOC54_RS04750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOC54_RS04760	COG0360	Binds together with S18 to 16S ribosomal RNA
FOC54_RS04770	COG0012	GTP binding
FOC54_RS04775	COG4481	Protein conserved in bacteria
FOC54_RS04780	COG0668	transmembrane transport
FOC54_RS04785	COG1475	DNA binding
FOC54_RS04790	COG0626	cystathionine gamma-synthase activity
FOC54_RS04795	COG0626	cystathionine gamma-synthase activity
FOC54_RS04800	COG0646	methionine synthase
FOC54_RS04800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC54_RS04805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC54_RS04835	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FOC54_RS04840	COG1461	Dihydroxyacetone kinase
FOC54_RS04845	COG2376	Dihydroxyacetone kinase
FOC54_RS04855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC54_RS04860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC54_RS04875	COG1136	(ABC) transporter
FOC54_RS04880	COG0577	efflux transmembrane transporter activity
FOC54_RS04915	COG0357	Ribosomal RNA small subunit methyltransferase G
FOC54_RS04920	COG0445	tRNA wobble uridine modification
FOC54_RS04925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FOC54_RS04930	COG0594	ribonuclease P activity
FOC54_RS04940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOC54_RS04945	COG0592	DNA-directed DNA polymerase activity
FOC54_RS04950	COG2501	S4 domain
FOC54_RS04955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOC54_RS04960	COG0187	DNA topoisomerase II activity
FOC54_RS04965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC54_RS04970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOC54_RS04975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOC54_RS04980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FOC54_RS04990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOC54_RS05000	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FOC54_RS05005	COG0359	binds to the 23S rRNA
FOC54_RS05010	COG0305	Participates in initiation and elongation during chromosome replication
FOC54_RS05015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOC54_RS05030	COG0745	RESPONSE REGULATOR receiver
FOC54_RS05035	COG5002	protein histidine kinase activity
FOC54_RS05040	COG4863	YycH protein
FOC54_RS05050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FOC54_RS05055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FOC54_RS05070	COG0477	Major facilitator Superfamily
FOC54_RS05100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC54_RS05115	COG2113	Glycine betaine
FOC54_RS05120	COG2409	Drug exporters of the RND superfamily
FOC54_RS05130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC54_RS05150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC54_RS05185	COG0640	Transcriptional regulator
FOC54_RS05190	COG0701	Predicted permease
FOC54_RS05200	COG2217	Heavy metal translocating P-type atpase
FOC54_RS05205	COG2132	Multicopper oxidase
FOC54_RS05210	COG1388	LysM domain
FOC54_RS05225	COG1063	alcohol dehydrogenase
FOC54_RS05235	COG1064	alcohol dehydrogenase
FOC54_RS05240	COG2910	NAD(P)H-binding
FOC54_RS05245	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FOC54_RS05250	COG1278	Cold shock
FOC54_RS05265	COG0523	cobalamin synthesis protein
FOC54_RS05280	COG0589	response to stress
FOC54_RS05285	COG0668	transmembrane transport
FOC54_RS05300	COG0471	metal ion transport
FOC54_RS05320	COG1114	Component of the transport system for branched-chain amino acids
FOC54_RS05325	COG1401	restriction endodeoxyribonuclease activity
FOC54_RS05335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC54_RS05340	COG1113	amino acid transport
FOC54_RS05345	COG0778	Nitroreductase
FOC54_RS05350	COG0753	catalase activity
FOC54_RS05400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOC54_RS05405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOC54_RS05410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FOC54_RS05420	COG1876	peptidase activity
FOC54_RS05435	COG1288	antiporter activity
FOC54_RS05450	COG2814	Major facilitator Superfamily
FOC54_RS05460	COG1846	Transcriptional regulator
FOC54_RS05465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC54_RS05470	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC54_RS05475	COG2855	membrane
FOC54_RS05480	COG0583	DNA-binding transcription factor activity
FOC54_RS05500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FOC54_RS05535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC54_RS05540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC54_RS05545	COG0022	dehydrogenase e1 component
FOC54_RS05550	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC54_RS05560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FOC54_RS05565	COG2962	Rard protein
FOC54_RS05590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC54_RS05590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC54_RS05595	COG1733	regulation of RNA biosynthetic process
FOC54_RS05635	COG1131	(ABC) transporter
FOC54_RS05660	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC54_RS05670	COG1397	ADP-ribosylglycohydrolase
FOC54_RS05680	COG1683	Conserved Protein
FOC54_RS05700	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC54_RS05715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOC54_RS05720	COG0549	Belongs to the carbamate kinase family
FOC54_RS05725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FOC54_RS05735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FOC54_RS05745	COG0363	glucosamine-6-phosphate deaminase activity
FOC54_RS05750	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FOC54_RS05755	COG1737	Transcriptional regulator
FOC54_RS05765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC54_RS05770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC54_RS05790	COG1124	(ABC) transporter
FOC54_RS05795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC54_RS05815	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FOC54_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS05825	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FOC54_RS05835	COG1054	Belongs to the UPF0176 family
FOC54_RS05840	COG3386	PFAM SMP-30 Gluconolaconase
FOC54_RS05845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC54_RS05850	COG0829	nickel cation binding
FOC54_RS05865	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FOC54_RS05870	COG0804	urea catabolic process
FOC54_RS05885	COG4413	Urea transporter
FOC54_RS05890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC54_RS05900	COG1686	Belongs to the peptidase S11 family
FOC54_RS05930	COG1131	(ABC) transporter
FOC54_RS05940	COG1476	TRANSCRIPTIONal
FOC54_RS05945	COG1959	2 iron, 2 sulfur cluster binding
FOC54_RS05955	COG2814	Major facilitator Superfamily
FOC54_RS05960	COG0737	Belongs to the 5'-nucleotidase family
FOC54_RS05975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FOC54_RS05980	COG3639	organic phosphonate transmembrane transporter activity
FOC54_RS05995	COG3391	amine dehydrogenase activity
FOC54_RS06000	COG0201	protein transport
FOC54_RS06010	COG1073	alpha beta
FOC54_RS06020	COG0653	protein targeting
FOC54_RS06035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC54_RS06055	COG0583	DNA-binding transcription factor activity
FOC54_RS06060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOC54_RS06070	COG1288	antiporter activity
FOC54_RS06075	COG1705	Flagellar rod assembly protein muramidase FlgJ
FOC54_RS06075	COG3942	CHAP domain
FOC54_RS06105	COG4974	Belongs to the 'phage' integrase family
FOC54_RS06140	COG3682	Transcriptional regulator
FOC54_RS06155	COG2235	arginine
FOC54_RS06170	COG2843	Capsule synthesis protein
FOC54_RS06175	COG3961	Belongs to the TPP enzyme family
FOC54_RS06200	COG1785	Belongs to the alkaline phosphatase family
FOC54_RS06205	COG0745	RESPONSE REGULATOR receiver
FOC54_RS06210	COG2205	protein histidine kinase activity
FOC54_RS06215	COG1136	(ABC) transporter
FOC54_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC54_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS06240	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC54_RS06265	COG0175	sulfate reduction
FOC54_RS06270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FOC54_RS06275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC54_RS06290	COG0730	response to heat
FOC54_RS06295	COG2046	Belongs to the sulfate adenylyltransferase family
FOC54_RS06300	COG0529	Catalyzes the synthesis of activated sulfate
FOC54_RS06305	COG3942	CHAP domain
FOC54_RS06315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC54_RS06320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC54_RS06325	COG1510	regulation of RNA biosynthetic process
FOC54_RS06330	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS06335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FOC54_RS06340	COG1473	amidohydrolase
FOC54_RS06355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC54_RS06360	COG0574	Belongs to the PEP-utilizing enzyme family
FOC54_RS06360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOC54_RS06365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC54_RS06370	COG0579	oxidoreductase
FOC54_RS06375	COG3588	fructose-bisphosphate aldolase
FOC54_RS06400	COG1464	Belongs to the NlpA lipoprotein family
FOC54_RS06410	COG0531	amino acid
FOC54_RS06415	COG0028	Belongs to the TPP enzyme family
FOC54_RS06420	COG3527	Alpha-acetolactate decarboxylase
FOC54_RS06435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC54_RS06445	COG0167	dihydroorotate dehydrogenase activity
FOC54_RS06450	COG3001	Fructosamine kinase
FOC54_RS06470	COG2226	methyltransferase
FOC54_RS06485	COG1309	transcriptional regulator
FOC54_RS06495	COG2326	polyphosphate kinase activity
FOC54_RS06500	COG0741	lytic transglycosylase activity
FOC54_RS06510	COG1233	COG1233 Phytoene dehydrogenase and related
FOC54_RS06515	COG0463	Glycosyl transferase, family 2
FOC54_RS06520	COG1562	ergosterol biosynthetic process
FOC54_RS06525	COG1233	COG1233 Phytoene dehydrogenase and related
FOC54_RS06530	COG0436	Aminotransferase
FOC54_RS06540	COG2608	mercury ion transmembrane transporter activity
FOC54_RS06545	COG2217	Heavy metal translocating P-type atpase
FOC54_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS06565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC54_RS06570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC54_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS06605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC54_RS06610	COG3425	synthase
FOC54_RS06615	COG0183	Belongs to the thiolase family
FOC54_RS06625	COG3942	CHAP domain
FOC54_RS06625	COG1388	LysM domain
FOC54_RS06635	COG0583	DNA-binding transcription factor activity
FOC54_RS06640	COG1380	Effector of murein hydrolase LrgA
FOC54_RS06645	COG1346	cytolysis
FOC54_RS06650	COG0028	Belongs to the TPP enzyme family
FOC54_RS06655	COG1263	PTS System
FOC54_RS06655	COG2190	(PTS) system
FOC54_RS06655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC54_RS06665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC54_RS06670	COG0039	L-malate dehydrogenase activity
FOC54_RS06685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC54_RS06705	COG1070	Carbohydrate kinase
FOC54_RS06720	COG1760	l-serine dehydratase
FOC54_RS06725	COG1760	l-serine dehydratase
FOC54_RS06740	COG3764	Sortase (surface protein transpeptidase)
FOC54_RS06745	COG0561	phosphatase activity
FOC54_RS06755	COG0778	Nitroreductase
FOC54_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS06770	COG2514	catechol 2,3-dioxygenase activity
FOC54_RS06780	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC54_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS06790	COG3949	Membrane
FOC54_RS06800	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FOC54_RS06805	COG0586	Pfam SNARE associated Golgi protein
FOC54_RS06810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC54_RS06815	COG2022	thiamine diphosphate biosynthetic process
FOC54_RS06820	COG2104	thiamine diphosphate biosynthetic process
FOC54_RS06820	COG2022	thiamine diphosphate biosynthetic process
FOC54_RS06825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC54_RS06835	COG2271	Major facilitator Superfamily
FOC54_RS06850	COG4876	unkown
FOC54_RS06855	COG2357	RelA SpoT domain protein
FOC54_RS06870	COG1802	Transcriptional regulator
FOC54_RS06875	COG1070	Carbohydrate kinase
FOC54_RS06880	COG2610	gluconate transmembrane transporter activity
FOC54_RS06885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOC54_RS06890	COG0494	nUDIX hydrolase
FOC54_RS06910	COG4221	oxidoreductase activity
FOC54_RS06915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC54_RS06920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC54_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS06935	COG1363	Peptidase, m42
FOC54_RS06945	COG0069	glutamate synthase activity
FOC54_RS06960	COG4619	ABC transporter
FOC54_RS06965	COG0390	transport system, permease component
FOC54_RS06970	COG2814	Major facilitator Superfamily
FOC54_RS06975	COG2272	Belongs to the type-B carboxylesterase lipase family
FOC54_RS06980	COG0531	amino acid
FOC54_RS06985	COG1063	alcohol dehydrogenase
FOC54_RS07005	COG1174	glycine betaine transport
FOC54_RS07010	COG1346	cytolysis
FOC54_RS07015	COG1380	Effector of murein hydrolase LrgA
FOC54_RS07020	COG3279	Response regulator of the LytR AlgR family
FOC54_RS07025	COG3275	phosphorelay sensor kinase activity
FOC54_RS07035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FOC54_RS07045	COG0706	membrane insertase activity
FOC54_RS07050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC54_RS07055	COG0531	amino acid
FOC54_RS07060	COG0025	NhaP-type Na H and K H
FOC54_RS07065	COG1113	amino acid transport
FOC54_RS07080	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FOC54_RS07085	COG2814	Major facilitator Superfamily
FOC54_RS07095	COG1929	Belongs to the glycerate kinase type-1 family
FOC54_RS07115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC54_RS07120	COG1388	LysM domain
FOC54_RS07125	COG0588	phosphoglycerate mutase activity
FOC54_RS07135	COG2814	Major facilitator Superfamily
FOC54_RS07140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC54_RS07145	COG0765	amino acid transport
FOC54_RS07150	COG1126	abc transporter atp-binding protein
FOC54_RS07155	COG2030	dehydratase
FOC54_RS07160	COG2348	transferase activity, transferring amino-acyl groups
FOC54_RS07175	COG2353	YceI-like domain
FOC54_RS07200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC54_RS07205	COG2146	nitrite reductase [NAD(P)H] activity
FOC54_RS07215	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FOC54_RS07220	COG1140	nitrate reductase beta subunit
FOC54_RS07230	COG2181	nitrate reductase activity
FOC54_RS07240	COG4585	Histidine kinase
FOC54_RS07245	COG2197	response regulator
FOC54_RS07250	COG2223	nitrite transmembrane transporter activity
FOC54_RS07260	COG1846	Transcriptional regulator
FOC54_RS07295	COG1309	transcriptional regulator
FOC54_RS07305	COG0534	Mate efflux family protein
FOC54_RS07330	COG1511	domain protein
FOC54_RS07330	COG4372	Transposase
FOC54_RS07330	COG1196	nuclear chromosome segregation
FOC54_RS07335	COG0604	alcohol dehydrogenase
FOC54_RS07340	COG2822	iron ion transport
FOC54_RS07345	COG2837	iron assimilation
FOC54_RS07350	COG0672	)-iron permease
FOC54_RS07355	COG0805	protein transport
FOC54_RS07360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC54_RS07375	COG1620	l-lactate permease
FOC54_RS07380	COG0438	transferase activity, transferring glycosyl groups
FOC54_RS07385	COG0579	oxidoreductase
FOC54_RS07390	COG3850	Histidine kinase
FOC54_RS07390	COG5002	protein histidine kinase activity
FOC54_RS07395	COG0745	RESPONSE REGULATOR receiver
FOC54_RS07400	COG0577	efflux transmembrane transporter activity
FOC54_RS07405	COG1136	(ABC) transporter
FOC54_RS07420	COG4640	response to antibiotic
FOC54_RS07425	COG2814	Major facilitator Superfamily
FOC54_RS07435	COG1566	PFAM secretion protein HlyD family protein
FOC54_RS07440	COG2814	Major facilitator Superfamily
FOC54_RS07465	COG0598	Magnesium transport protein CorA
FOC54_RS07470	COG1304	FMN binding
FOC54_RS07475	COG2094	Belongs to the DNA glycosylase MPG family
FOC54_RS07480	COG1742	UPF0060 membrane protein
FOC54_RS07485	COG2017	converts alpha-aldose to the beta-anomer
FOC54_RS07490	COG2258	MOSC domain
FOC54_RS07495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FOC54_RS07500	COG1266	CAAX protease self-immunity
FOC54_RS07510	COG1473	amidohydrolase
FOC54_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS07520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FOC54_RS07535	COG1737	Transcriptional regulator
FOC54_RS07540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC54_RS07540	COG1263	PTS System
FOC54_RS07550	COG0385	Bile acid
FOC54_RS07555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC54_RS07580	COG1113	amino acid transport
FOC54_RS07595	COG2378	regulation of single-species biofilm formation
FOC54_RS07605	COG1316	TRANSCRIPTIONal
FOC54_RS07610	COG3383	formate dehydrogenase (NAD+) activity
FOC54_RS07635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC54_RS07640	COG2076	Multidrug Resistance protein
FOC54_RS07645	COG2076	Multidrug Resistance protein
FOC54_RS07660	COG1757	Na H antiporter
FOC54_RS07665	COG3942	CHAP domain
FOC54_RS07670	COG2207	Transcriptional regulator
FOC54_RS07685	COG1960	acyl-CoA dehydrogenase activity
FOC54_RS07695	COG1268	BioY protein
FOC54_RS07705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOC54_RS07710	COG0725	ABC transporter, periplasmic molybdate-binding protein
FOC54_RS07715	COG4149	molybdate abc transporter
FOC54_RS07720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FOC54_RS07725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC54_RS07730	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC54_RS07735	COG0315	cyclic pyranopterin monophosphate synthase activity
FOC54_RS07745	COG1763	Mo-molybdopterin cofactor biosynthetic process
FOC54_RS07760	COG0746	molybdenum cofactor guanylyltransferase activity
FOC54_RS07765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FOC54_RS07795	COG2348	transferase activity, transferring amino-acyl groups
FOC54_RS07800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOC54_RS07820	COG4975	Glucose uptake
FOC54_RS07825	COG0551	DNA topoisomerase type I activity
FOC54_RS07825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC54_RS07830	COG2252	PERMEase
FOC54_RS07845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOC54_RS07850	COG0088	Forms part of the polypeptide exit tunnel
FOC54_RS07855	COG0089	rRNA binding
FOC54_RS07860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOC54_RS07865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOC54_RS07870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOC54_RS07875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOC54_RS07880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOC54_RS07890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOC54_RS07895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOC54_RS07900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOC54_RS07905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOC54_RS07915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOC54_RS07920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC54_RS07925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOC54_RS07930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOC54_RS07935	COG1841	ribosomal large subunit assembly
FOC54_RS07945	COG0201	protein transport
FOC54_RS07950	COG0563	adenylate kinase activity
FOC54_RS07955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOC54_RS07960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOC54_RS07965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOC54_RS07975	COG0202	RNA polymerase activity
FOC54_RS07980	COG0203	ribosomal protein L17
FOC54_RS07985	COG1122	ATPase activity
FOC54_RS08000	COG0101	tRNA pseudouridine synthase activity
FOC54_RS08005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOC54_RS08015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOC54_RS08020	COG1349	DNA-binding transcription factor activity
FOC54_RS08025	COG0698	ribose 5-phosphate isomerase
FOC54_RS08030	COG0698	ribose 5-phosphate isomerase
FOC54_RS08035	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC54_RS08040	COG3684	Belongs to the aldolase LacD family
FOC54_RS08045	COG1447	Phosphotransferase system cellobiose-specific component IIA
FOC54_RS08050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC54_RS08050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC54_RS08080	COG3561	AntA/AntB antirepressor
FOC54_RS08145	COG1484	DNA-dependent DNA replication
FOC54_RS08230	COG0756	dUTP diphosphatase activity
FOC54_RS08345	COG5280	Phage tail tape measure protein TP901
FOC54_RS08345	COG3953	SLT domain
FOC54_RS08370	COG4824	toxin secretion phage lysis holin
FOC54_RS08390	COG1388	LysM domain
FOC54_RS08390	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC54_RS08400	COG2723	6-phospho-beta-galactosidase activity
FOC54_RS08410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC54_RS08415	COG2130	NADP-dependent
FOC54_RS08420	COG0604	alcohol dehydrogenase
FOC54_RS08425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC54_RS08440	COG1302	Protein conserved in bacteria
FOC54_RS08445	COG4264	IucA IucC family
FOC54_RS08455	COG3457	Alanine racemase
FOC54_RS08460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC54_RS08465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC54_RS08470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC54_RS08475	COG3314	Sporulation integral membrane protein YlbJ
FOC54_RS08480	COG2329	Antibiotic biosynthesis monooxygenase
FOC54_RS08485	COG1988	membrane-bound metal-dependent
FOC54_RS08490	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FOC54_RS08495	COG1272	protein, Hemolysin III
FOC54_RS08510	COG0489	protein tyrosine kinase activity
FOC54_RS08560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FOC54_RS08570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC54_RS08580	COG1119	ATPase activity
FOC54_RS08585	COG0561	phosphatase activity
FOC54_RS08610	COG0640	Transcriptional regulator
FOC54_RS08615	COG0702	epimerase
FOC54_RS08620	COG1482	cell wall glycoprotein biosynthetic process
FOC54_RS08635	COG0783	Belongs to the Dps family
FOC54_RS08640	COG0813	purine-nucleoside phosphorylase activity
FOC54_RS08645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FOC54_RS08650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FOC54_RS08655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FOC54_RS08670	COG1854	S-ribosylhomocysteine lyase activity
FOC54_RS08690	COG5146	pantothenate kinase activity
FOC54_RS08705	COG0504	CTP synthase activity
FOC54_RS08715	COG0191	fructose-bisphosphate aldolase activity
FOC54_RS08720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC54_RS08730	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS08735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FOC54_RS08740	COG0254	rRNA binding
FOC54_RS08745	COG1435	thymidine kinase activity
FOC54_RS08750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOC54_RS08755	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC54_RS08760	COG0009	L-threonylcarbamoyladenylate synthase
FOC54_RS08765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC54_RS08770	COG4475	Protein of unknown function (DUF436)
FOC54_RS08775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOC54_RS08780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOC54_RS08785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC54_RS08795	COG0356	it plays a direct role in the translocation of protons across the membrane
FOC54_RS08800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC54_RS08805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOC54_RS08810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC54_RS08815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FOC54_RS08820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOC54_RS08825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOC54_RS08830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOC54_RS08840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC54_RS08845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC54_RS08855	COG0629	single-stranded DNA binding
FOC54_RS08860	COG1388	LysM domain
FOC54_RS08865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC54_RS08875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FOC54_RS08880	COG0352	thiamine-phosphate diphosphorylase activity
FOC54_RS08885	COG0706	membrane insertase activity
FOC54_RS08890	COG1418	mRNA catabolic process
FOC54_RS08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC54_RS08900	COG1937	Protein conserved in bacteria
FOC54_RS08915	COG0772	Belongs to the SEDS family
FOC54_RS08920	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOC54_RS08925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FOC54_RS08930	COG0513	Belongs to the DEAD box helicase family
FOC54_RS08940	COG3428	Bacterial PH domain
FOC54_RS08950	COG0736	holo-[acyl-carrier-protein] synthase activity
FOC54_RS08955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC54_RS08965	COG2337	Toxic component of a toxin-antitoxin (TA) module
FOC54_RS08970	COG2208	phosphoserine phosphatase activity
FOC54_RS08985	COG1191	sigma factor activity
FOC54_RS08990	COG2183	response to ionizing radiation
FOC54_RS08995	COG3091	SprT-like family
FOC54_RS09025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOC54_RS09030	COG0066	3-isopropylmalate dehydratase activity
FOC54_RS09035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOC54_RS09040	COG0473	3-isopropylmalate dehydrogenase activity
FOC54_RS09045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOC54_RS09050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOC54_RS09060	COG0028	Belongs to the TPP enzyme family
FOC54_RS09065	COG0129	dihydroxy-acid dehydratase activity
FOC54_RS09070	COG0802	atpase or kinase
FOC54_RS09075	COG1214	PFAM Peptidase M22, glycoprotease
FOC54_RS09080	COG0456	acetyltransferase
FOC54_RS09085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC54_RS09090	COG0488	(ABC) transporter
FOC54_RS09095	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FOC54_RS09100	COG2391	methyltransferase activity
FOC54_RS09105	COG0425	Belongs to the sulfur carrier protein TusA family
FOC54_RS09110	COG0004	ammonium transporteR
FOC54_RS09115	COG1621	beta-fructofuranosidase activity
FOC54_RS09120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC54_RS09125	COG3279	Response regulator of the LytR AlgR family
FOC54_RS09140	COG4512	PFAM Accessory gene regulator B
FOC54_RS09165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOC54_RS09170	COG0459	protein refolding
FOC54_RS09180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOC54_RS09180	COG0519	Catalyzes the synthesis of GMP from XMP
FOC54_RS09195	COG1725	Transcriptional regulator
FOC54_RS09210	COG1131	(ABC) transporter
FOC54_RS09245	COG2706	6-phosphogluconolactonase activity
FOC54_RS09250	COG1012	belongs to the aldehyde dehydrogenase family
FOC54_RS09255	COG1227	inorganic diphosphatase activity
FOC54_RS09260	COG1335	isochorismatase
FOC54_RS09275	COG0077	Prephenate dehydratase
FOC54_RS09285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOC54_RS09290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOC54_RS09295	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FOC54_RS09305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC54_RS09310	COG4496	protein, YerC YecD
FOC54_RS09315	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FOC54_RS09320	COG0210	DNA helicase
FOC54_RS09325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC54_RS09330	COG4851	CamS sex pheromone cAM373 precursor
FOC54_RS09335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC54_RS09340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOC54_RS09345	COG0154	amidase activity
FOC54_RS09350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOC54_RS09355	COG1597	lipid kinase activity
FOC54_RS09360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC54_RS09370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC54_RS09390	COG4129	membrane
FOC54_RS09395	COG0024	Methionine aminopeptidase
FOC54_RS09400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FOC54_RS09415	COG4585	Histidine kinase
FOC54_RS09420	COG2197	response regulator
FOC54_RS09425	COG1295	ribonuclease BN
FOC54_RS09435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC54_RS09440	COG4840	Belongs to the UPF0435 family
FOC54_RS09445	COG2309	aminopeptidase activity
FOC54_RS09450	COG1607	acyl-coa hydrolase
FOC54_RS09455	COG0535	radical SAM domain protein
FOC54_RS09465	COG0693	protein deglycase activity
FOC54_RS09470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC54_RS09475	COG2137	regulation of response to DNA damage stimulus
FOC54_RS09485	COG1134	teichoic acid transport
FOC54_RS09485	COG1388	LysM domain
FOC54_RS09495	COG1988	membrane-bound metal-dependent
FOC54_RS09500	COG1194	a g-specific adenine glycosylase
FOC54_RS09505	COG3557	Belongs to the UPF0374 family
FOC54_RS09515	COG4129	membrane
FOC54_RS09520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC54_RS09525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FOC54_RS09535	COG0735	belongs to the Fur family
FOC54_RS09705	COG0765	amino acid transport
FOC54_RS09710	COG1126	abc transporter atp-binding protein
FOC54_RS09715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC54_RS09725	COG0363	glucosamine-6-phosphate deaminase activity
FOC54_RS09740	COG0114	fumarate hydratase activity
FOC54_RS09745	COG0564	pseudouridine synthase activity
FOC54_RS09750	COG2203	Gaf domain
FOC54_RS09750	COG4585	Histidine kinase
FOC54_RS09755	COG2197	response regulator
FOC54_RS09765	COG4399	Belongs to the UPF0754 family
FOC54_RS09770	COG3679	Belongs to the UPF0342 family
FOC54_RS09780	COG4717	serine-type aminopeptidase activity
FOC54_RS09790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC54_RS09805	COG0537	adenosine 5'-monophosphoramidase activity
FOC54_RS09810	COG1131	(ABC) transporter
FOC54_RS09815	COG4473	ABC transporter
FOC54_RS09820	COG2329	Antibiotic biosynthesis monooxygenase
FOC54_RS09825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOC54_RS09830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FOC54_RS09835	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FOC54_RS09885	COG0318	PFAM AMP-dependent synthetase and ligase
FOC54_RS09895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FOC54_RS09900	COG0494	nUDIX hydrolase
FOC54_RS09905	COG1506	peptidase
FOC54_RS09910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FOC54_RS09915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOC54_RS09925	COG0656	L-ascorbic acid biosynthetic process
FOC54_RS09930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC54_RS09935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC54_RS09945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC54_RS09970	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC54_RS09970	COG4193	domain, Protein
FOC54_RS09970	COG3266	domain, Protein
FOC54_RS09980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC54_RS09980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC54_RS09990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC54_RS09990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC54_RS09995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOC54_RS10000	COG0506	proline dehydrogenase activity
FOC54_RS10005	COG2267	carboxylic ester hydrolase activity
FOC54_RS10015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FOC54_RS10020	COG1242	4 iron, 4 sulfur cluster binding
FOC54_RS10025	COG2814	Major facilitator Superfamily
FOC54_RS10030	COG0495	leucyl-tRNA aminoacylation
FOC54_RS10045	COG2081	HI0933 family
FOC54_RS10050	COG2244	polysaccharide biosynthetic process
FOC54_RS10055	COG1187	pseudouridine synthase activity
FOC54_RS10065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC54_RS10075	COG0510	thiamine kinase activity
FOC54_RS10080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC54_RS10090	COG1363	Peptidase, m42
FOC54_RS10100	COG4848	Belongs to the UPF0354 family
FOC54_RS10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC54_RS10110	COG1674	ftsk spoiiie
FOC54_RS10115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOC54_RS10120	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FOC54_RS10130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOC54_RS10130	COG1605	Chorismate mutase
FOC54_RS10135	COG1609	Transcriptional regulator
FOC54_RS10140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FOC54_RS10155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC54_RS10160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC54_RS10165	COG0204	Acyl-transferase
FOC54_RS10170	COG1263	PTS System
FOC54_RS10170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC54_RS10180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC54_RS10190	COG1764	response to oxidative stress
FOC54_RS10195	COG0584	glycerophosphoryl diester phosphodiesterase
FOC54_RS10200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOC54_RS10210	COG1956	GAF domain-containing protein
FOC54_RS10215	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FOC54_RS10225	COG0301	tRNA thio-modification
FOC54_RS10235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC54_RS10240	COG0827	DNA restriction-modification system
FOC54_RS10245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC54_RS10250	COG0589	response to stress
FOC54_RS10255	COG0686	Belongs to the AlaDH PNT family
FOC54_RS10260	COG0006	proline dipeptidase activity
FOC54_RS10265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC54_RS10275	COG4109	DRTGG domain
FOC54_RS10280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC54_RS10285	COG0587	DNA-directed DNA polymerase activity
FOC54_RS10290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FOC54_RS10295	COG0825	malonyl-CoA metabolic process
FOC54_RS10300	COG0205	6-phosphofructokinase activity
FOC54_RS10305	COG0469	pyruvate kinase activity
FOC54_RS10310	COG1113	amino acid transport
FOC54_RS10315	COG0372	Belongs to the citrate synthase family
FOC54_RS10320	COG0538	isocitrate dehydrogenase activity
FOC54_RS10325	COG0745	RESPONSE REGULATOR receiver
FOC54_RS10330	COG5002	protein histidine kinase activity
FOC54_RS10335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC54_RS10335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC54_RS10340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOC54_RS10345	COG0237	dephospho-CoA kinase activity
FOC54_RS10355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOC54_RS10360	COG3611	Membrane attachment protein
FOC54_RS10365	COG1484	DNA-dependent DNA replication
FOC54_RS10370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC54_RS10375	COG0833	amino acid
FOC54_RS10380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC54_RS10385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOC54_RS10390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOC54_RS10395	COG4112	unkown
FOC54_RS10405	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOC54_RS10410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOC54_RS10415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOC54_RS10420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOC54_RS10425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC54_RS10430	COG0181	hydroxymethylbilane synthase activity
FOC54_RS10445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC54_RS10455	COG2818	Glycosylase
FOC54_RS10460	COG0525	valine-tRNA ligase activity
FOC54_RS10465	COG0285	dihydrofolate synthase activity
FOC54_RS10475	COG2003	Belongs to the UPF0758 family
FOC54_RS10500	COG1792	Involved in formation and maintenance of cell shape
FOC54_RS10510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOC54_RS10515	COG2868	ribosomal protein
FOC54_RS10520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOC54_RS10525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOC54_RS10535	COG0632	four-way junction helicase activity
FOC54_RS10540	COG2255	four-way junction helicase activity
FOC54_RS10545	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FOC54_RS10555	COG1862	Preprotein translocase
FOC54_RS10560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC54_RS10560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC54_RS10565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FOC54_RS10565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC54_RS10570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC54_RS10575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC54_RS10580	COG1490	D-aminoacyl-tRNA deacylase activity
FOC54_RS10585	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC54_RS10590	COG0124	histidyl-tRNA synthetase
FOC54_RS10595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOC54_RS10605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOC54_RS10610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC54_RS10615	COG1959	2 iron, 2 sulfur cluster binding
FOC54_RS10625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC54_RS10630	COG1104	cysteine desulfurase activity
FOC54_RS10635	COG0482	sulfurtransferase activity
FOC54_RS10645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC54_RS10650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC54_RS10655	COG4472	Bacterial protein of unknown function (DUF965)
FOC54_RS10660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOC54_RS10665	COG3906	Belongs to the UPF0473 family
FOC54_RS10675	COG0826	peptidase U32
FOC54_RS10680	COG0826	peptidase U32
FOC54_RS10685	COG0572	uridine kinase
FOC54_RS10690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOC54_RS10695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC54_RS10700	COG1984	allophanate hydrolase subunit 2
FOC54_RS10710	COG0439	Biotin carboxylase
FOC54_RS10715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FOC54_RS10720	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC54_RS10725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC54_RS10730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FOC54_RS10735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FOC54_RS10740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FOC54_RS10745	COG1534	Rna-binding protein
FOC54_RS10750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOC54_RS10755	COG1713	HD superfamily hydrolase involved in NAD metabolism
FOC54_RS10760	COG0799	negative regulation of ribosome biogenesis
FOC54_RS10765	COG2226	methyltransferase
FOC54_RS10775	COG2131	deaminase
FOC54_RS10780	COG2333	competence protein COMEC
FOC54_RS10780	COG0658	competence protein
FOC54_RS10785	COG1466	dna polymerase III delta subunit
FOC54_RS10790	COG0268	Binds directly to 16S ribosomal RNA
FOC54_RS10795	COG0481	GTPase activity
FOC54_RS10800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC54_RS10805	COG1420	regulation of RNA biosynthetic process
FOC54_RS10810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC54_RS10815	COG0443	Heat shock 70 kDa protein
FOC54_RS10820	COG0484	heat shock protein binding
FOC54_RS10825	COG2264	protein methyltransferase activity
FOC54_RS10830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC54_RS10835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC54_RS10845	COG1030	water channel activity
FOC54_RS10850	COG4864	UPF0365 protein
FOC54_RS10860	COG1702	phosphate starvation-inducible protein PhoH
FOC54_RS10870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FOC54_RS10875	COG0295	cytidine deaminase activity
FOC54_RS10880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC54_RS10885	COG1381	Involved in DNA repair and RecF pathway recombination
FOC54_RS10890	COG0423	glycine-tRNA ligase activity
FOC54_RS10895	COG0517	IMP dehydrogenase activity
FOC54_RS10900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC54_RS10905	COG0358	DNA primase activity
FOC54_RS10910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC54_RS10915	COG2384	SAM-dependent methyltransferase
FOC54_RS10920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC54_RS10925	COG0513	Belongs to the DEAD box helicase family
FOC54_RS10930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOC54_RS10935	COG1121	(ABC) transporter
FOC54_RS10940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC54_RS10950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC54_RS10955	COG0768	penicillin binding
FOC54_RS10965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FOC54_RS10975	COG4483	Protein conserved in bacteria
FOC54_RS10980	COG1940	carbohydrate kinase activity
FOC54_RS10985	COG0011	TIGRFAM Protein of
FOC54_RS10990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC54_RS10995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FOC54_RS11000	COG1459	type II secretion system
FOC54_RS11005	COG4537	Required for transformation and DNA binding
FOC54_RS11025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOC54_RS11030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FOC54_RS11035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOC54_RS11040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOC54_RS11045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC54_RS11050	COG0095	Lipoate-protein ligase
FOC54_RS11065	COG0006	proline dipeptidase activity
FOC54_RS11070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOC54_RS11075	COG0511	ligase activity, forming carbon-carbon bonds
FOC54_RS11080	COG0439	Biotin carboxylase
FOC54_RS11085	COG1302	Protein conserved in bacteria
FOC54_RS11090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC54_RS11095	COG1570	exodeoxyribonuclease VII activity
FOC54_RS11105	COG0142	geranyltranstransferase activity
FOC54_RS11110	COG1438	arginine binding
FOC54_RS11115	COG0497	DNA recombination
FOC54_RS11120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC54_RS11125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC54_RS11130	COG0022	dehydrogenase e1 component
FOC54_RS11135	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC54_RS11145	COG4129	membrane
FOC54_RS11155	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC54_RS11165	COG0366	Alpha amylase catalytic
FOC54_RS11175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOC54_RS11180	COG1234	tRNA 3'-trailer cleavage
FOC54_RS11185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC54_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
FOC54_RS11195	COG0667	Aldo Keto reductase
FOC54_RS11200	COG0494	nUDIX hydrolase
FOC54_RS11205	COG0735	belongs to the Fur family
FOC54_RS11210	COG4974	Belongs to the 'phage' integrase family
FOC54_RS11220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FOC54_RS11225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FOC54_RS11230	COG1187	pseudouridine synthase activity
FOC54_RS11235	COG0745	RESPONSE REGULATOR receiver
FOC54_RS11240	COG5002	protein histidine kinase activity
FOC54_RS11250	COG1141	Ferredoxin
FOC54_RS11260	COG0514	ATP-dependent DNA helicase (RecQ)
FOC54_RS11265	COG1388	LysM domain
FOC54_RS11265	COG1388	LysM domain
FOC54_RS11270	COG0492	ferredoxin-NADP+ reductase activity
FOC54_RS11280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FOC54_RS11285	COG0539	negative regulation of cytoplasmic translation
FOC54_RS11290	COG1160	GTP binding
FOC54_RS11295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOC54_RS11310	COG2226	methyltransferase
FOC54_RS11315	COG0142	geranyltranstransferase activity
FOC54_RS11320	COG0105	UTP biosynthetic process
FOC54_RS11325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOC54_RS11330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOC54_RS11335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOC54_RS11340	COG0457	Tetratricopeptide repeat
FOC54_RS11345	COG5582	Belongs to the UPF0302 family
FOC54_RS11355	COG2738	Putative neutral zinc metallopeptidase
FOC54_RS11360	COG1694	Mazg nucleotide pyrophosphohydrolase
FOC54_RS11365	COG0438	transferase activity, transferring glycosyl groups
FOC54_RS11370	COG0617	tRNA 3'-terminal CCA addition
FOC54_RS11380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOC54_RS11380	COG1199	ATP-dependent helicase activity
FOC54_RS11385	COG0017	Asparaginyl-tRNA synthetase
FOC54_RS11390	COG3935	DnaD domain protein
FOC54_RS11395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC54_RS11405	COG4499	WXG100 protein secretion system (Wss), protein YukC
FOC54_RS11405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC54_RS11410	COG3331	DNA recombination
FOC54_RS11420	COG4474	Belongs to the UPF0398 family
FOC54_RS11425	COG3599	regulation of cell shape
FOC54_RS11435	COG0116	Belongs to the methyltransferase superfamily
FOC54_RS11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC54_RS11450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC54_RS11455	COG0328	RNA-DNA hybrid ribonuclease activity
FOC54_RS11470	COG1413	lyase activity
FOC54_RS11475	COG1413	lyase activity
FOC54_RS11505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC54_RS11510	COG2190	(PTS) system
FOC54_RS11515	COG4479	Belongs to the UPF0346 family
FOC54_RS11520	COG0793	Belongs to the peptidase S41A family
FOC54_RS11530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC54_RS11535	COG0671	phosphoesterase, PA-phosphatase related
FOC54_RS11540	COG0745	RESPONSE REGULATOR receiver
FOC54_RS11545	COG5002	protein histidine kinase activity
FOC54_RS11550	COG0567	Dehydrogenase, E1 component
FOC54_RS11570	COG0714	Associated with various cellular activities
FOC54_RS11575	COG4548	von Willebrand factor, type A
FOC54_RS11580	COG1114	Component of the transport system for branched-chain amino acids
FOC54_RS11585	COG3853	Toxic anion resistance protein (TelA)
FOC54_RS11595	COG1254	Belongs to the acylphosphatase family
FOC54_RS11605	COG1278	Cold shock
FOC54_RS11620	COG1473	amidohydrolase
FOC54_RS11625	COG2171	N-acyltransferase activity
FOC54_RS11630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOC54_RS11635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC54_RS11640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC54_RS11645	COG0527	aspartate kinase activity
FOC54_RS11650	COG0488	(ABC) transporter
FOC54_RS11655	COG2996	Protein conserved in bacteria
FOC54_RS11660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC54_RS11665	COG0573	inorganic phosphate transmembrane transporter activity
FOC54_RS11670	COG0581	inorganic phosphate transmembrane transporter activity
FOC54_RS11675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOC54_RS11680	COG0704	Plays a role in the regulation of phosphate uptake
FOC54_RS11695	COG4607	ABC-type enterochelin transport system periplasmic component
FOC54_RS11705	COG2348	transferase activity, transferring amino-acyl groups
FOC54_RS11710	COG0159	tryptophan synthase activity
FOC54_RS11720	COG0135	phosphoribosylanthranilate isomerase activity
FOC54_RS11725	COG0134	indole-3-glycerol-phosphate synthase activity
FOC54_RS11730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC54_RS11735	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC54_RS11740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC54_RS11750	COG0287	Prephenate dehydrogenase
FOC54_RS11755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC54_RS11760	COG1942	4-Oxalocrotonate Tautomerase
FOC54_RS11775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FOC54_RS11775	COG0392	lysyltransferase activity
FOC54_RS11785	COG0628	permease
FOC54_RS11790	COG3711	transcriptional antiterminator
FOC54_RS11795	COG1115	amino acid carrier protein
FOC54_RS11800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC54_RS11805	COG0187	DNA topoisomerase II activity
FOC54_RS11810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FOC54_RS11815	COG4841	protein insertion into membrane
FOC54_RS11820	COG0824	Thioesterase
FOC54_RS11825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOC54_RS11830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC54_RS11835	COG1970	mechanosensitive ion channel activity