locus-tag	class	description
SHYC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SHYC_RS00010	COG0592	DNA-directed DNA polymerase activity
SHYC_RS00030	COG0187	DNA topoisomerase II activity
SHYC_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SHYC_RS00045	COG2986	histidine ammonia-lyase
SHYC_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SHYC_RS00115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SHYC_RS00125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHYC_RS00130	COG4241	membrane
SHYC_RS00135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SHYC_RS00140	COG0359	binds to the 23S rRNA
SHYC_RS00145	COG0305	Participates in initiation and elongation during chromosome replication
SHYC_RS00150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SHYC_RS00175	COG5002	protein histidine kinase activity
SHYC_RS00180	COG4863	YycH protein
SHYC_RS00190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SHYC_RS00200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SHYC_RS00205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHYC_RS00230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SHYC_RS00240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SHYC_RS00250	COG2091	lysine biosynthetic process via aminoadipic acid
SHYC_RS00255	COG1021	2,3-dihydroxybenzoate-AMP ligase
SHYC_RS00260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHYC_RS00260	COG2226	methyltransferase
SHYC_RS00260	COG3433	isochorismatase activity
SHYC_RS00290	COG1129	ABC transporter
SHYC_RS00300	COG1132	(ABC) transporter
SHYC_RS00310	COG1169	isochorismate synthase
SHYC_RS00320	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SHYC_RS00325	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SHYC_RS00335	COG2205	protein histidine kinase activity
SHYC_RS00340	COG0745	RESPONSE REGULATOR receiver
SHYC_RS00350	COG2423	ornithine cyclodeaminase activity
SHYC_RS00355	COG4264	IucA IucC family
SHYC_RS00360	COG2814	Major facilitator Superfamily
SHYC_RS00365	COG4264	IucA IucC family
SHYC_RS00370	COG4264	IucA IucC family
SHYC_RS00380	COG0019	diaminopimelate decarboxylase activity
SHYC_RS00385	COG1475	DNA binding
SHYC_RS00410	COG1473	amidohydrolase
SHYC_RS00425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SHYC_RS00430	COG2814	Major facilitator Superfamily
SHYC_RS00445	COG0039	L-malate dehydrogenase activity
SHYC_RS00450	COG1328	CTP reductase activity
SHYC_RS00475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SHYC_RS00475	COG3266	domain, Protein
SHYC_RS00475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SHYC_RS00475	COG3266	domain, Protein
SHYC_RS00475	COG4932	domain protein
SHYC_RS00475	COG4932	domain protein
SHYC_RS00530	COG3620	sequence-specific DNA binding
SHYC_RS00605	COG1705	Flagellar rod assembly protein muramidase FlgJ
SHYC_RS00605	COG3942	CHAP domain
SHYC_RS00620	COG4716	Myosin-crossreactive antigen
SHYC_RS00630	COG3443	Belongs to the bacterial solute-binding protein 9 family
SHYC_RS00630	COG0803	Belongs to the bacterial solute-binding protein 9 family
SHYC_RS00635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS00640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS00645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHYC_RS00670	COG3655	Transcriptional regulator
SHYC_RS00675	COG2723	6-phospho-beta-galactosidase activity
SHYC_RS00680	COG2188	Transcriptional regulator
SHYC_RS00685	COG0456	acetyltransferase
SHYC_RS00690	COG2311	Membrane
SHYC_RS00710	COG2188	Transcriptional regulator
SHYC_RS00715	COG0813	purine-nucleoside phosphorylase activity
SHYC_RS00720	COG2814	Major facilitator Superfamily
SHYC_RS00760	COG0702	epimerase
SHYC_RS00770	COG0415	Belongs to the DNA photolyase family
SHYC_RS00800	COG1174	glycine betaine transport
SHYC_RS00810	COG1174	glycine betaine transport
SHYC_RS00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHYC_RS00860	COG0579	oxidoreductase
SHYC_RS00865	COG1755	Isoprenylcysteine carboxyl methyltransferase
SHYC_RS00870	COG1113	amino acid transport
SHYC_RS00885	COG2205	protein histidine kinase activity
SHYC_RS00895	COG0745	RESPONSE REGULATOR receiver
SHYC_RS00900	COG2205	protein histidine kinase activity
SHYC_RS00905	COG1136	(ABC) transporter
SHYC_RS00925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHYC_RS00945	COG1518	maintenance of DNA repeat elements
SHYC_RS00975	COG2205	protein histidine kinase activity
SHYC_RS00975	COG3292	Two component regulator propeller
SHYC_RS00975	COG0745	RESPONSE REGULATOR receiver
SHYC_RS00980	COG0800	Aldolase
SHYC_RS00985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHYC_RS00990	COG2211	Major facilitator Superfamily
SHYC_RS00995	COG1904	glucuronate isomerase
SHYC_RS01000	COG1312	Catalyzes the dehydration of D-mannonate
SHYC_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS01010	COG3250	beta-galactosidase activity
SHYC_RS01025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SHYC_RS01030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHYC_RS01035	COG0156	8-amino-7-oxononanoate synthase activity
SHYC_RS01045	COG1620	l-lactate permease
SHYC_RS01065	COG1073	alpha beta
SHYC_RS01090	COG0384	phenazine biosynthesis protein PhzF
SHYC_RS01095	COG0183	Belongs to the thiolase family
SHYC_RS01105	COG1960	acyl-CoA dehydrogenase activity
SHYC_RS01110	COG0318	PFAM AMP-dependent synthetase and ligase
SHYC_RS01140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHYC_RS01145	COG0730	response to heat
SHYC_RS01150	COG1937	Protein conserved in bacteria
SHYC_RS01155	COG2210	Belongs to the sulfur carrier protein TusA family
SHYC_RS01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHYC_RS01165	COG1609	Transcriptional regulator
SHYC_RS01170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHYC_RS01175	COG1869	D-ribose catabolic process
SHYC_RS01180	COG1129	ABC transporter
SHYC_RS01185	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHYC_RS01190	COG1879	ABC-type sugar transport system periplasmic component
SHYC_RS01205	COG0025	NhaP-type Na H and K H
SHYC_RS01210	COG3314	Sporulation integral membrane protein YlbJ
SHYC_RS01215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHYC_RS01220	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS01235	COG3192	ethanolamine utilization protein
SHYC_RS01250	COG3711	transcriptional antiterminator
SHYC_RS01255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHYC_RS01270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SHYC_RS01295	COG2814	Major facilitator Superfamily
SHYC_RS01370	COG2814	Major facilitator Superfamily
SHYC_RS01375	COG1335	isochorismatase
SHYC_RS01405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SHYC_RS01410	COG2814	Major facilitator Superfamily
SHYC_RS01415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHYC_RS01425	COG1115	amino acid carrier protein
SHYC_RS01435	COG0741	lytic transglycosylase activity
SHYC_RS01440	COG0477	Major facilitator Superfamily
SHYC_RS01445	COG0668	transmembrane transport
SHYC_RS01465	COG4195	phage-related replication protein
SHYC_RS01470	COG4485	Bacterial membrane protein, YfhO
SHYC_RS01490	COG2843	Capsule synthesis protein
SHYC_RS01520	COG2205	protein histidine kinase activity
SHYC_RS01525	COG0745	RESPONSE REGULATOR receiver
SHYC_RS01530	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SHYC_RS01545	COG0586	Pfam SNARE associated Golgi protein
SHYC_RS01555	COG1785	Belongs to the alkaline phosphatase family
SHYC_RS01560	COG1785	Belongs to the alkaline phosphatase family
SHYC_RS01590	COG1510	regulation of RNA biosynthetic process
SHYC_RS01595	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS01600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SHYC_RS01605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHYC_RS01615	COG0107	imidazoleglycerol-phosphate synthase activity
SHYC_RS01620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SHYC_RS01635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHYC_RS01640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SHYC_RS01650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SHYC_RS01665	COG2271	Major facilitator Superfamily
SHYC_RS01670	COG2376	Dihydroxyacetone kinase
SHYC_RS01675	COG1461	Dihydroxyacetone kinase
SHYC_RS01690	COG2824	Alkylphosphonate utilization operon protein PhnA
SHYC_RS01695	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS01710	COG0596	Alpha beta hydrolase
SHYC_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHYC_RS01720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHYC_RS01720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHYC_RS01725	COG2814	Major facilitator Superfamily
SHYC_RS01735	COG3942	CHAP domain
SHYC_RS01735	COG1705	Flagellar rod assembly protein muramidase FlgJ
SHYC_RS01755	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SHYC_RS01760	COG0463	Glycosyl transferase, family 2
SHYC_RS01760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHYC_RS01780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SHYC_RS01780	COG1263	PTS System
SHYC_RS01790	COG0778	Nitroreductase
SHYC_RS01795	COG3001	Fructosamine kinase
SHYC_RS01815	COG1136	(ABC) transporter
SHYC_RS01820	COG0577	efflux transmembrane transporter activity
SHYC_RS01825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHYC_RS01830	COG0745	RESPONSE REGULATOR receiver
SHYC_RS01835	COG5002	protein histidine kinase activity
SHYC_RS01850	COG4413	Urea transporter
SHYC_RS01860	COG0832	Belongs to the urease beta subunit family
SHYC_RS01865	COG0804	urea catabolic process
SHYC_RS01880	COG0717	Belongs to the dCTP deaminase family
SHYC_RS01885	COG0523	cobalamin synthesis protein
SHYC_RS01895	COG1114	Component of the transport system for branched-chain amino acids
SHYC_RS01900	COG3189	MarR family transcriptional regulator
SHYC_RS01905	COG5505	Protein of unknown function (DUF819)
SHYC_RS01920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS01925	COG4605	iron ion homeostasis
SHYC_RS01930	COG4604	ABC transporter, ATP-binding protein
SHYC_RS01935	COG4607	ABC-type enterochelin transport system periplasmic component
SHYC_RS01940	COG1846	Transcriptional regulator
SHYC_RS01945	COG0778	Nitroreductase
SHYC_RS01950	COG2357	RelA SpoT domain protein
SHYC_RS01985	COG2814	Major facilitator Superfamily
SHYC_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS02000	COG0753	catalase activity
SHYC_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS02070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SHYC_RS02095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SHYC_RS02100	COG0110	maltose O-acetyltransferase activity
SHYC_RS02105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SHYC_RS02125	COG3835	regulator
SHYC_RS02130	COG3961	Belongs to the TPP enzyme family
SHYC_RS02135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SHYC_RS02140	COG0512	Glutamine amidotransferase of anthranilate synthase
SHYC_RS02145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHYC_RS02150	COG0134	indole-3-glycerol-phosphate synthase activity
SHYC_RS02155	COG0135	phosphoribosylanthranilate isomerase activity
SHYC_RS02165	COG0159	tryptophan synthase activity
SHYC_RS02170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SHYC_RS02185	COG0277	FAD linked oxidase domain protein
SHYC_RS02190	COG0247	lactate metabolic process
SHYC_RS02195	COG1132	(ABC) transporter
SHYC_RS02200	COG1132	(ABC) transporter
SHYC_RS02205	COG0346	lactoylglutathione lyase activity
SHYC_RS02210	COG3871	stress protein (general stress protein 26)
SHYC_RS02215	COG1115	amino acid carrier protein
SHYC_RS02220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SHYC_RS02225	COG2814	Major facilitator Superfamily
SHYC_RS02230	COG2271	Major facilitator Superfamily
SHYC_RS02235	COG3764	Sortase (surface protein transpeptidase)
SHYC_RS02240	COG1929	Belongs to the glycerate kinase type-1 family
SHYC_RS02245	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SHYC_RS02260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SHYC_RS02270	COG0702	epimerase
SHYC_RS02280	COG0444	Belongs to the ABC transporter superfamily
SHYC_RS02285	COG4608	Belongs to the ABC transporter superfamily
SHYC_RS02290	COG0601	transmembrane transport
SHYC_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHYC_RS02310	COG1760	l-serine dehydratase
SHYC_RS02315	COG1760	l-serine dehydratase
SHYC_RS02335	COG0471	metal ion transport
SHYC_RS02350	COG0454	-acetyltransferase
SHYC_RS02365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHYC_RS02370	COG2146	nitrite reductase [NAD(P)H] activity
SHYC_RS02375	COG1648	precorrin-2 dehydrogenase activity
SHYC_RS02375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHYC_RS02380	COG0737	Belongs to the 5'-nucleotidase family
SHYC_RS02385	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SHYC_RS02390	COG1140	nitrate reductase beta subunit
SHYC_RS02395	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SHYC_RS02400	COG2181	nitrate reductase activity
SHYC_RS02410	COG4585	Histidine kinase
SHYC_RS02415	COG2197	response regulator
SHYC_RS02420	COG2223	nitrite transmembrane transporter activity
SHYC_RS02425	COG4187	Peptidase family M20/M25/M40
SHYC_RS02435	COG1363	Peptidase, m42
SHYC_RS02440	COG0697	spore germination
SHYC_RS02455	COG2807	transmembrane transport
SHYC_RS02460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SHYC_RS02475	COG1846	Transcriptional regulator
SHYC_RS02480	COG1283	sodium-dependent phosphate transmembrane transporter activity
SHYC_RS02505	COG0492	ferredoxin-NADP+ reductase activity
SHYC_RS02510	COG2814	Major facilitator Superfamily
SHYC_RS02515	COG0604	alcohol dehydrogenase
SHYC_RS02530	COG1620	l-lactate permease
SHYC_RS02545	COG5002	protein histidine kinase activity
SHYC_RS02545	COG3850	Histidine kinase
SHYC_RS02560	COG1136	(ABC) transporter
SHYC_RS02590	COG0657	acetylesterase activity
SHYC_RS02605	COG1304	FMN binding
SHYC_RS02610	COG0523	cobalamin synthesis protein
SHYC_RS02615	COG0786	glutamate:sodium symporter activity
SHYC_RS02620	COG2207	Transcriptional regulator
SHYC_RS02630	COG1757	Na H antiporter
SHYC_RS02635	COG2094	Belongs to the DNA glycosylase MPG family
SHYC_RS02645	COG4152	abc transporter atp-binding protein
SHYC_RS02650	COG1668	transmembrane transport
SHYC_RS02655	COG1742	UPF0060 membrane protein
SHYC_RS02660	COG2017	converts alpha-aldose to the beta-anomer
SHYC_RS02670	COG2258	MOSC domain
SHYC_RS02675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SHYC_RS02680	COG1266	CAAX protease self-immunity
SHYC_RS02690	COG0583	DNA-binding transcription factor activity
SHYC_RS02695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SHYC_RS02700	COG1228	amidohydrolase
SHYC_RS02705	COG1473	amidohydrolase
SHYC_RS02725	COG0385	Bile acid
SHYC_RS02735	COG0346	lactoylglutathione lyase activity
SHYC_RS02740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHYC_RS02765	COG1113	amino acid transport
SHYC_RS02790	COG1316	TRANSCRIPTIONal
SHYC_RS02795	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SHYC_RS02800	COG3383	formate dehydrogenase (NAD+) activity
SHYC_RS02845	COG1757	Na H antiporter
SHYC_RS02855	COG3942	CHAP domain
SHYC_RS02880	COG1960	acyl-CoA dehydrogenase activity
SHYC_RS02885	COG2832	Protein of unknown function (DUF454)
SHYC_RS02890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHYC_RS02895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHYC_RS02915	COG1268	BioY protein
SHYC_RS02930	COG0725	ABC transporter, periplasmic molybdate-binding protein
SHYC_RS02935	COG4149	molybdate abc transporter
SHYC_RS02940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SHYC_RS02945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SHYC_RS02950	COG0521	Mo-molybdopterin cofactor biosynthetic process
SHYC_RS02955	COG0315	cyclic pyranopterin monophosphate synthase activity
SHYC_RS02965	COG1763	Mo-molybdopterin cofactor biosynthetic process
SHYC_RS02970	COG0314	molybdopterin synthase activity
SHYC_RS02980	COG0746	molybdenum cofactor guanylyltransferase activity
SHYC_RS03010	COG2348	transferase activity, transferring amino-acyl groups
SHYC_RS03015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SHYC_RS03020	COG0436	Aminotransferase
SHYC_RS03050	COG2252	PERMEase
SHYC_RS03060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHYC_RS03065	COG0088	Forms part of the polypeptide exit tunnel
SHYC_RS03070	COG0089	rRNA binding
SHYC_RS03075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SHYC_RS03080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SHYC_RS03085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SHYC_RS03090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SHYC_RS03100	COG0255	Belongs to the universal ribosomal protein uL29 family
SHYC_RS03110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SHYC_RS03115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SHYC_RS03125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHYC_RS03130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SHYC_RS03150	COG1841	ribosomal large subunit assembly
SHYC_RS03160	COG0201	protein transport
SHYC_RS03175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SHYC_RS03185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SHYC_RS03190	COG0202	RNA polymerase activity
SHYC_RS03195	COG0203	ribosomal protein L17
SHYC_RS03205	COG1122	ATPase activity
SHYC_RS03215	COG0101	tRNA pseudouridine synthase activity
SHYC_RS03225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHYC_RS03235	COG0789	Transcriptional regulator
SHYC_RS03240	COG2226	methyltransferase
SHYC_RS03260	COG1349	DNA-binding transcription factor activity
SHYC_RS03275	COG3684	Belongs to the aldolase LacD family
SHYC_RS03290	COG2723	6-phospho-beta-galactosidase activity
SHYC_RS03295	COG0604	alcohol dehydrogenase
SHYC_RS03300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SHYC_RS03305	COG2814	Major facilitator Superfamily
SHYC_RS03310	COG4264	IucA IucC family
SHYC_RS03315	COG2814	Major facilitator Superfamily
SHYC_RS03320	COG4264	IucA IucC family
SHYC_RS03325	COG3457	Alanine racemase
SHYC_RS03330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SHYC_RS03335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS03340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS03350	COG1988	membrane-bound metal-dependent
SHYC_RS03355	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SHYC_RS03360	COG1272	protein, Hemolysin III
SHYC_RS03375	COG2814	Major facilitator Superfamily
SHYC_RS03380	COG0489	protein tyrosine kinase activity
SHYC_RS03445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHYC_RS03455	COG1119	ATPase activity
SHYC_RS03460	COG0561	phosphatase activity
SHYC_RS03470	COG2186	Transcriptional regulator
SHYC_RS03475	COG1482	cell wall glycoprotein biosynthetic process
SHYC_RS03490	COG1757	Na H antiporter
SHYC_RS03500	COG0813	purine-nucleoside phosphorylase activity
SHYC_RS03535	COG5146	pantothenate kinase activity
SHYC_RS03550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHYC_RS03560	COG0504	CTP synthase activity
SHYC_RS03570	COG0191	fructose-bisphosphate aldolase activity
SHYC_RS03575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHYC_RS03580	COG1733	regulation of RNA biosynthetic process
SHYC_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS03590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SHYC_RS03595	COG0254	rRNA binding
SHYC_RS03605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SHYC_RS03610	COG2890	protein-(glutamine-N5) methyltransferase activity
SHYC_RS03615	COG0009	L-threonylcarbamoyladenylate synthase
SHYC_RS03620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHYC_RS03625	COG4475	Protein of unknown function (DUF436)
SHYC_RS03635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SHYC_RS03640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SHYC_RS03650	COG0356	it plays a direct role in the translocation of protons across the membrane
SHYC_RS03655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHYC_RS03665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHYC_RS03670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SHYC_RS03675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SHYC_RS03695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHYC_RS03705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHYC_RS03720	COG1388	LysM domain
SHYC_RS03725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SHYC_RS03735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SHYC_RS03740	COG0352	thiamine-phosphate diphosphorylase activity
SHYC_RS03745	COG0706	membrane insertase activity
SHYC_RS03750	COG1418	mRNA catabolic process
SHYC_RS03760	COG1937	Protein conserved in bacteria
SHYC_RS03770	COG2608	mercury ion transmembrane transporter activity
SHYC_RS03775	COG2217	Heavy metal translocating P-type atpase
SHYC_RS03780	COG0772	Belongs to the SEDS family
SHYC_RS03790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHYC_RS03795	COG0513	Belongs to the DEAD box helicase family
SHYC_RS03815	COG0736	holo-[acyl-carrier-protein] synthase activity
SHYC_RS03830	COG2337	Toxic component of a toxin-antitoxin (TA) module
SHYC_RS03835	COG2208	phosphoserine phosphatase activity
SHYC_RS03850	COG1191	sigma factor activity
SHYC_RS03855	COG2183	response to ionizing radiation
SHYC_RS03860	COG3091	SprT-like family
SHYC_RS03890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHYC_RS03895	COG0066	3-isopropylmalate dehydratase activity
SHYC_RS03900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHYC_RS03910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHYC_RS03920	COG0440	acetolactate synthase activity
SHYC_RS03925	COG0028	Belongs to the TPP enzyme family
SHYC_RS03930	COG0129	dihydroxy-acid dehydratase activity
SHYC_RS03935	COG0802	atpase or kinase
SHYC_RS03940	COG1214	PFAM Peptidase M22, glycoprotease
SHYC_RS03945	COG0456	acetyltransferase
SHYC_RS03950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SHYC_RS03965	COG0488	(ABC) transporter
SHYC_RS03975	COG2391	methyltransferase activity
SHYC_RS03980	COG0425	Belongs to the sulfur carrier protein TusA family
SHYC_RS03985	COG1621	beta-fructofuranosidase activity
SHYC_RS04005	COG4512	PFAM Accessory gene regulator B
SHYC_RS04025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SHYC_RS04045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHYC_RS04065	COG1131	(ABC) transporter
SHYC_RS04075	COG1802	Transcriptional regulator
SHYC_RS04080	COG1070	Carbohydrate kinase
SHYC_RS04085	COG2610	gluconate transmembrane transporter activity
SHYC_RS04090	COG4876	unkown
SHYC_RS04125	COG2706	6-phosphogluconolactonase activity
SHYC_RS04130	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS04140	COG1227	inorganic diphosphatase activity
SHYC_RS04145	COG1335	isochorismatase
SHYC_RS04155	COG0077	Prephenate dehydratase
SHYC_RS04165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SHYC_RS04170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SHYC_RS04175	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SHYC_RS04190	COG4496	protein, YerC YecD
SHYC_RS04205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHYC_RS04210	COG4851	CamS sex pheromone cAM373 precursor
SHYC_RS04215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHYC_RS04220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHYC_RS04230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHYC_RS04235	COG1597	lipid kinase activity
SHYC_RS04255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHYC_RS04265	COG1528	Iron-storage protein
SHYC_RS04280	COG4129	membrane
SHYC_RS04310	COG0288	reversible hydration of carbon dioxide
SHYC_RS04315	COG1295	ribonuclease BN
SHYC_RS04325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHYC_RS04330	COG4840	Belongs to the UPF0435 family
SHYC_RS04335	COG2309	aminopeptidase activity
SHYC_RS04340	COG1607	acyl-coa hydrolase
SHYC_RS04345	COG0535	radical SAM domain protein
SHYC_RS04350	COG0693	protein deglycase activity
SHYC_RS04360	COG0028	Belongs to the TPP enzyme family
SHYC_RS04365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHYC_RS04370	COG2137	regulation of response to DNA damage stimulus
SHYC_RS04380	COG1388	LysM domain
SHYC_RS04380	COG1134	teichoic acid transport
SHYC_RS04390	COG1988	membrane-bound metal-dependent
SHYC_RS04395	COG1194	a g-specific adenine glycosylase
SHYC_RS04400	COG3557	Belongs to the UPF0374 family
SHYC_RS04410	COG0069	glutamate synthase activity
SHYC_RS04415	COG4129	membrane
SHYC_RS04420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHYC_RS04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SHYC_RS04430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHYC_RS04435	COG0735	belongs to the Fur family
SHYC_RS04585	COG0765	amino acid transport
SHYC_RS04590	COG1126	abc transporter atp-binding protein
SHYC_RS04595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SHYC_RS04605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SHYC_RS04610	COG0363	glucosamine-6-phosphate deaminase activity
SHYC_RS04620	COG0114	fumarate hydratase activity
SHYC_RS04630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SHYC_RS04635	COG0564	pseudouridine synthase activity
SHYC_RS04640	COG2203	Gaf domain
SHYC_RS04640	COG4585	Histidine kinase
SHYC_RS04645	COG2197	response regulator
SHYC_RS04655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SHYC_RS04670	COG1301	dicarboxylic acid transport
SHYC_RS04735	COG2433	Pfam Transposase IS66
SHYC_RS04745	COG0741	lytic transglycosylase activity
SHYC_RS04745	COG1196	nuclear chromosome segregation
SHYC_RS04745	COG0739	heme binding
SHYC_RS04750	COG0582	viral genome integration into host DNA
SHYC_RS04820	COG4373	Mu-like prophage FluMu protein gp28
SHYC_RS04850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHYC_RS04940	COG2887	Belongs to the helicase family. UvrD subfamily
SHYC_RS04950	COG0305	Participates in initiation and elongation during chromosome replication
SHYC_RS04960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SHYC_RS05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHYC_RS05090	COG1404	Belongs to the peptidase S8 family
SHYC_RS05120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SHYC_RS05185	COG0270	DNA (cytosine-5-)-methyltransferase activity
SHYC_RS05225	COG1780	Probably involved in ribonucleotide reductase function
SHYC_RS05230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHYC_RS05230	COG1372	Participates in initiation and elongation during chromosome replication
SHYC_RS05235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHYC_RS05275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SHYC_RS05280	COG1301	dicarboxylic acid transport
SHYC_RS05315	COG4399	Belongs to the UPF0754 family
SHYC_RS05320	COG3679	Belongs to the UPF0342 family
SHYC_RS05325	COG0420	3'-5' exonuclease activity
SHYC_RS05330	COG4717	serine-type aminopeptidase activity
SHYC_RS05335	COG3481	metal-dependent phosphohydrolase, HD sub domain
SHYC_RS05340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SHYC_RS05350	COG1846	Transcriptional regulator
SHYC_RS05360	COG0537	adenosine 5'-monophosphoramidase activity
SHYC_RS05365	COG1131	(ABC) transporter
SHYC_RS05375	COG2329	Antibiotic biosynthesis monooxygenase
SHYC_RS05380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SHYC_RS05390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHYC_RS05485	COG1302	Protein conserved in bacteria
SHYC_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
SHYC_RS05515	COG1506	peptidase
SHYC_RS05520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SHYC_RS05525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SHYC_RS05535	COG0656	L-ascorbic acid biosynthetic process
SHYC_RS05540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SHYC_RS05555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHYC_RS05570	COG1595	DNA-templated transcription, initiation
SHYC_RS05580	COG3266	domain, Protein
SHYC_RS05580	COG4193	domain, Protein
SHYC_RS05580	COG5632	N-Acetylmuramoyl-L-alanine amidase
SHYC_RS05590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHYC_RS05590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHYC_RS05600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHYC_RS05600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHYC_RS05605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SHYC_RS05610	COG0506	proline dehydrogenase activity
SHYC_RS05620	COG2267	carboxylic ester hydrolase activity
SHYC_RS05625	COG0039	L-malate dehydrogenase activity
SHYC_RS05635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SHYC_RS05640	COG1242	4 iron, 4 sulfur cluster binding
SHYC_RS05645	COG2814	Major facilitator Superfamily
SHYC_RS05650	COG0495	leucyl-tRNA aminoacylation
SHYC_RS05655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHYC_RS05665	COG2081	HI0933 family
SHYC_RS05670	COG2244	polysaccharide biosynthetic process
SHYC_RS05675	COG1187	pseudouridine synthase activity
SHYC_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHYC_RS05690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SHYC_RS05695	COG0510	thiamine kinase activity
SHYC_RS05700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SHYC_RS05705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHYC_RS05715	COG1363	Peptidase, m42
SHYC_RS05720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHYC_RS05725	COG4848	Belongs to the UPF0354 family
SHYC_RS05730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHYC_RS05735	COG1674	ftsk spoiiie
SHYC_RS05740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SHYC_RS05745	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SHYC_RS05755	COG1605	Chorismate mutase
SHYC_RS05755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SHYC_RS05760	COG1609	Transcriptional regulator
SHYC_RS05765	COG0123	including yeast histone deacetylase and acetoin utilization protein
SHYC_RS05770	COG0454	-acetyltransferase
SHYC_RS05775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHYC_RS05780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SHYC_RS05785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SHYC_RS05795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHYC_RS05800	COG0204	Acyl-transferase
SHYC_RS05810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHYC_RS05815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SHYC_RS05820	COG1764	response to oxidative stress
SHYC_RS05825	COG0584	glycerophosphoryl diester phosphodiesterase
SHYC_RS05835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHYC_RS05840	COG1956	GAF domain-containing protein
SHYC_RS05845	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SHYC_RS05850	COG1104	cysteine desulfurase activity
SHYC_RS05855	COG0301	tRNA thio-modification
SHYC_RS05860	COG0730	response to heat
SHYC_RS05865	COG0616	signal peptide processing
SHYC_RS05870	COG1714	RDD family
SHYC_RS05875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SHYC_RS05880	COG0827	DNA restriction-modification system
SHYC_RS05885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SHYC_RS05890	COG0589	response to stress
SHYC_RS05905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHYC_RS05915	COG4109	DRTGG domain
SHYC_RS05920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SHYC_RS05925	COG0587	DNA-directed DNA polymerase activity
SHYC_RS05930	COG0281	malic enzyme
SHYC_RS05935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SHYC_RS05940	COG0825	malonyl-CoA metabolic process
SHYC_RS05945	COG0205	6-phosphofructokinase activity
SHYC_RS05950	COG0469	pyruvate kinase activity
SHYC_RS05955	COG0372	Belongs to the citrate synthase family
SHYC_RS05965	COG0745	RESPONSE REGULATOR receiver
SHYC_RS05970	COG5002	protein histidine kinase activity
SHYC_RS05975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHYC_RS05975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHYC_RS05980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHYC_RS05990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SHYC_RS05995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SHYC_RS06000	COG3611	Membrane attachment protein
SHYC_RS06005	COG1484	DNA-dependent DNA replication
SHYC_RS06010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHYC_RS06015	COG0833	amino acid
SHYC_RS06020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SHYC_RS06025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SHYC_RS06030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SHYC_RS06045	COG0544	peptidyl-prolyl cis-trans isomerase activity
SHYC_RS06055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SHYC_RS06060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SHYC_RS06065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHYC_RS06095	COG2818	Glycosylase
SHYC_RS06100	COG0525	valine-tRNA ligase activity
SHYC_RS06105	COG0285	dihydrofolate synthase activity
SHYC_RS06115	COG2003	Belongs to the UPF0758 family
SHYC_RS06125	COG1792	Involved in formation and maintenance of cell shape
SHYC_RS06135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SHYC_RS06140	COG2868	ribosomal protein
SHYC_RS06155	COG4492	Belongs to the UPF0735 family
SHYC_RS06160	COG0632	four-way junction helicase activity
SHYC_RS06165	COG2255	four-way junction helicase activity
SHYC_RS06180	COG1862	Preprotein translocase
SHYC_RS06185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHYC_RS06185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHYC_RS06190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SHYC_RS06190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SHYC_RS06195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHYC_RS06205	COG1490	D-aminoacyl-tRNA deacylase activity
SHYC_RS06210	COG0860	N-Acetylmuramoyl-L-alanine amidase
SHYC_RS06220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SHYC_RS06225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SHYC_RS06230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SHYC_RS06235	COG1959	2 iron, 2 sulfur cluster binding
SHYC_RS06250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHYC_RS06255	COG1104	cysteine desulfurase activity
SHYC_RS06260	COG0482	sulfurtransferase activity
SHYC_RS06270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHYC_RS06275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHYC_RS06280	COG4472	Bacterial protein of unknown function (DUF965)
SHYC_RS06285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SHYC_RS06290	COG3906	Belongs to the UPF0473 family
SHYC_RS06295	COG4122	O-methyltransferase activity
SHYC_RS06300	COG0826	peptidase U32
SHYC_RS06305	COG0826	peptidase U32
SHYC_RS06310	COG0572	uridine kinase
SHYC_RS06315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SHYC_RS06320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SHYC_RS06325	COG1984	allophanate hydrolase subunit 2
SHYC_RS06330	COG0511	ligase activity, forming carbon-carbon bonds
SHYC_RS06335	COG0439	Biotin carboxylase
SHYC_RS06340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHYC_RS06345	COG1914	H( )-stimulated, divalent metal cation uptake system
SHYC_RS06350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHYC_RS06355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SHYC_RS06360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SHYC_RS06370	COG1534	Rna-binding protein
SHYC_RS06380	COG1713	HD superfamily hydrolase involved in NAD metabolism
SHYC_RS06385	COG0799	negative regulation of ribosome biogenesis
SHYC_RS06390	COG2226	methyltransferase
SHYC_RS06395	COG1596	polysaccharide export
SHYC_RS06395	COG1555	photosystem II stabilization
SHYC_RS06400	COG2131	deaminase
SHYC_RS06405	COG2333	competence protein COMEC
SHYC_RS06405	COG0658	competence protein
SHYC_RS06410	COG1466	dna polymerase III delta subunit
SHYC_RS06415	COG0268	Binds directly to 16S ribosomal RNA
SHYC_RS06425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SHYC_RS06430	COG1420	regulation of RNA biosynthetic process
SHYC_RS06435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHYC_RS06445	COG0484	heat shock protein binding
SHYC_RS06455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SHYC_RS06460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHYC_RS06475	COG4864	UPF0365 protein
SHYC_RS06485	COG1702	phosphate starvation-inducible protein PhoH
SHYC_RS06490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SHYC_RS06500	COG0295	cytidine deaminase activity
SHYC_RS06505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SHYC_RS06510	COG1381	Involved in DNA repair and RecF pathway recombination
SHYC_RS06515	COG0423	glycine-tRNA ligase activity
SHYC_RS06520	COG0517	IMP dehydrogenase activity
SHYC_RS06525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SHYC_RS06530	COG0358	DNA primase activity
SHYC_RS06535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHYC_RS06540	COG2384	SAM-dependent methyltransferase
SHYC_RS06545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SHYC_RS06550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHYC_RS06555	COG0513	Belongs to the DEAD box helicase family
SHYC_RS06560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SHYC_RS06565	COG1121	(ABC) transporter
SHYC_RS06570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SHYC_RS06580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHYC_RS06590	COG0768	penicillin binding
SHYC_RS06595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SHYC_RS06600	COG0573	inorganic phosphate transmembrane transporter activity
SHYC_RS06605	COG0581	inorganic phosphate transmembrane transporter activity
SHYC_RS06610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SHYC_RS06615	COG0704	Plays a role in the regulation of phosphate uptake
SHYC_RS06620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHYC_RS06625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SHYC_RS06630	COG0705	Rhomboid family
SHYC_RS06635	COG4483	Protein conserved in bacteria
SHYC_RS06640	COG1940	carbohydrate kinase activity
SHYC_RS06645	COG0011	TIGRFAM Protein of
SHYC_RS06650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHYC_RS06655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SHYC_RS06660	COG1459	type II secretion system
SHYC_RS06685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SHYC_RS06690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SHYC_RS06695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHYC_RS06700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHYC_RS06705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHYC_RS06710	COG0095	Lipoate-protein ligase
SHYC_RS06725	COG0006	proline dipeptidase activity
SHYC_RS06730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SHYC_RS06735	COG0511	ligase activity, forming carbon-carbon bonds
SHYC_RS06740	COG0439	Biotin carboxylase
SHYC_RS06745	COG1302	Protein conserved in bacteria
SHYC_RS06755	COG1570	exodeoxyribonuclease VII activity
SHYC_RS06770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHYC_RS06775	COG1438	arginine binding
SHYC_RS06780	COG0497	DNA recombination
SHYC_RS06785	COG0280	phosphate acetyltransferase
SHYC_RS06790	COG3426	butyrate kinase activity
SHYC_RS06795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHYC_RS06800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SHYC_RS06805	COG0022	dehydrogenase e1 component
SHYC_RS06810	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHYC_RS06820	COG4129	membrane
SHYC_RS06825	COG2195	Cleaves the N-terminal amino acid of tripeptides
SHYC_RS06840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SHYC_RS06845	COG1234	tRNA 3'-trailer cleavage
SHYC_RS06850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SHYC_RS06860	COG0667	Aldo Keto reductase
SHYC_RS06865	COG0494	nUDIX hydrolase
SHYC_RS06870	COG0735	belongs to the Fur family
SHYC_RS06875	COG4974	Belongs to the 'phage' integrase family
SHYC_RS06885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SHYC_RS06890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SHYC_RS06895	COG1187	pseudouridine synthase activity
SHYC_RS06900	COG0745	RESPONSE REGULATOR receiver
SHYC_RS06905	COG5002	protein histidine kinase activity
SHYC_RS06915	COG1141	Ferredoxin
SHYC_RS06925	COG0514	ATP-dependent DNA helicase (RecQ)
SHYC_RS06935	COG0492	ferredoxin-NADP+ reductase activity
SHYC_RS06940	COG0252	asparaginase activity
SHYC_RS06945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SHYC_RS06950	COG0539	negative regulation of cytoplasmic translation
SHYC_RS06960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHYC_RS06975	COG2226	methyltransferase
SHYC_RS06980	COG0142	geranyltranstransferase activity
SHYC_RS06985	COG0105	UTP biosynthetic process
SHYC_RS06990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SHYC_RS06995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SHYC_RS07005	COG0457	Tetratricopeptide repeat
SHYC_RS07010	COG5582	Belongs to the UPF0302 family
SHYC_RS07015	COG4347	Protein of unknown function (DUF1405)
SHYC_RS07020	COG2738	Putative neutral zinc metallopeptidase
SHYC_RS07025	COG1694	Mazg nucleotide pyrophosphohydrolase
SHYC_RS07030	COG0438	transferase activity, transferring glycosyl groups
SHYC_RS07050	COG0017	Asparaginyl-tRNA synthetase
SHYC_RS07055	COG3935	DnaD domain protein
SHYC_RS07060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SHYC_RS07070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHYC_RS07070	COG4499	WXG100 protein secretion system (Wss), protein YukC
SHYC_RS07075	COG3331	DNA recombination
SHYC_RS07085	COG4474	Belongs to the UPF0398 family
SHYC_RS07095	COG0116	Belongs to the methyltransferase superfamily
SHYC_RS07100	COG2962	Rard protein
SHYC_RS07105	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SHYC_RS07110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHYC_RS07115	COG0328	RNA-DNA hybrid ribonuclease activity
SHYC_RS07120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SHYC_RS07130	COG1413	lyase activity
SHYC_RS07140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SHYC_RS07160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHYC_RS07170	COG4479	Belongs to the UPF0346 family
SHYC_RS07190	COG0671	phosphoesterase, PA-phosphatase related
SHYC_RS07195	COG0745	RESPONSE REGULATOR receiver
SHYC_RS07200	COG5002	protein histidine kinase activity
SHYC_RS07205	COG0567	Dehydrogenase, E1 component
SHYC_RS07225	COG0714	Associated with various cellular activities
SHYC_RS07230	COG4548	von Willebrand factor, type A
SHYC_RS07235	COG1114	Component of the transport system for branched-chain amino acids
SHYC_RS07240	COG3853	Toxic anion resistance protein (TelA)
SHYC_RS07260	COG1278	Cold shock
SHYC_RS07280	COG1473	amidohydrolase
SHYC_RS07290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SHYC_RS07300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SHYC_RS07305	COG0488	(ABC) transporter
SHYC_RS07310	COG2996	Protein conserved in bacteria
SHYC_RS07315	COG1105	Belongs to the carbohydrate kinase PfkB family
SHYC_RS07330	COG2348	transferase activity, transferring amino-acyl groups
SHYC_RS07335	COG2348	transferase activity, transferring amino-acyl groups
SHYC_RS07340	COG1363	Peptidase, m42
SHYC_RS07345	COG0287	Prephenate dehydrogenase
SHYC_RS07350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHYC_RS07380	COG0628	permease
SHYC_RS07390	COG3711	transcriptional antiterminator
SHYC_RS07395	COG1115	amino acid carrier protein
SHYC_RS07400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHYC_RS07405	COG0187	DNA topoisomerase II activity
SHYC_RS07410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SHYC_RS07420	COG0824	Thioesterase
SHYC_RS07430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SHYC_RS07445	COG0420	3'-5' exonuclease activity
SHYC_RS07450	COG4846	Membrane protein involved in cytochrome C biogenesis
SHYC_RS07455	COG3763	UPF0154 protein
SHYC_RS07465	COG4224	UPF0291 protein
SHYC_RS07475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SHYC_RS07485	COG2340	Cysteine-rich secretory protein family
SHYC_RS07490	COG0516	GMP reductase activity
SHYC_RS07495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHYC_RS07505	COG0753	catalase activity
SHYC_RS07510	COG0833	amino acid
SHYC_RS07520	COG0561	phosphatase activity
SHYC_RS07525	COG0083	homoserine kinase activity
SHYC_RS07530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHYC_RS07535	COG0460	homoserine dehydrogenase
SHYC_RS07540	COG0527	aspartate kinase activity
SHYC_RS07570	COG2197	response regulator
SHYC_RS07575	COG4585	Histidine kinase
SHYC_RS07580	COG0842	Transport permease protein
SHYC_RS07585	COG4172	Belongs to the ABC transporter superfamily
SHYC_RS07615	COG0789	Transcriptional regulator
SHYC_RS07620	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SHYC_RS07625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SHYC_RS07635	COG1923	regulation of RNA biosynthetic process
SHYC_RS07645	COG2267	carboxylic ester hydrolase activity
SHYC_RS07650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHYC_RS07660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHYC_RS07665	COG1619	proteins homologs of microcin C7 resistance protein MccF
SHYC_RS07675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SHYC_RS07695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHYC_RS07705	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHYC_RS07710	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHYC_RS07710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHYC_RS07715	COG1692	metallophosphoesterase
SHYC_RS07735	COG1418	mRNA catabolic process
SHYC_RS07740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SHYC_RS07745	COG1546	Belongs to the CinA family
SHYC_RS07745	COG1058	Belongs to the CinA family
SHYC_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS07770	COG0612	Peptidase, M16
SHYC_RS07775	COG0612	Peptidase, M16
SHYC_RS07780	COG2188	Transcriptional regulator
SHYC_RS07790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHYC_RS07800	COG1185	polyribonucleotide nucleotidyltransferase activity
SHYC_RS07810	COG0196	riboflavin kinase activity
SHYC_RS07815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SHYC_RS07820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SHYC_RS07830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SHYC_RS07835	COG1358	cellular component organization or biogenesis
SHYC_RS07840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SHYC_RS07845	COG0195	Participates in both transcription termination and antitermination
SHYC_RS07850	COG0779	Required for maturation of 30S ribosomal subunits
SHYC_RS07860	COG0442	prolyl-tRNA aminoacylation
SHYC_RS07870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SHYC_RS07875	COG4589	Belongs to the CDS family
SHYC_RS07880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHYC_RS07885	COG0233	cytoplasmic translational termination
SHYC_RS07890	COG0528	UMP kinase activity
SHYC_RS07895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SHYC_RS07900	COG0052	Belongs to the universal ribosomal protein uS2 family
SHYC_RS07905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SHYC_RS07910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SHYC_RS07920	COG4974	Belongs to the 'phage' integrase family
SHYC_RS07925	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SHYC_RS07930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SHYC_RS07935	COG0758	DNA mediated transformation
SHYC_RS07945	COG0045	succinate-CoA ligase (ADP-forming) activity
SHYC_RS07955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHYC_RS07970	COG4485	Bacterial membrane protein, YfhO
SHYC_RS07985	COG0335	large ribosomal subunit rRNA binding
SHYC_RS07990	COG0336	Belongs to the RNA methyltransferase TrmD family
SHYC_RS08000	COG0228	four-way junction DNA binding
SHYC_RS08005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SHYC_RS08010	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SHYC_RS08015	COG0552	protein localization to endoplasmic reticulum
SHYC_RS08020	COG1196	nuclear chromosome segregation
SHYC_RS08025	COG0571	ribonuclease III activity
SHYC_RS08030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHYC_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
SHYC_RS08045	COG0416	fatty acid biosynthetic process
SHYC_RS08050	COG1349	DNA-binding transcription factor activity
SHYC_RS08055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SHYC_RS08060	COG1760	l-serine dehydratase
SHYC_RS08065	COG1760	l-serine dehydratase
SHYC_RS08075	COG1302	Protein conserved in bacteria
SHYC_RS08085	COG1564	THIamine pyrophosphokinase
SHYC_RS08090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SHYC_RS08095	COG1162	GTPase activity
SHYC_RS08100	COG2124	cytochrome p450
SHYC_RS08110	COG0631	protein serine/threonine phosphatase activity
SHYC_RS08115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SHYC_RS08120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHYC_RS08120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHYC_RS08125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SHYC_RS08140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SHYC_RS08145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SHYC_RS08150	COG1758	RNA polymerase activity
SHYC_RS08170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SHYC_RS08175	COG0284	orotidine-5'-phosphate decarboxylase activity
SHYC_RS08180	COG0167	dihydroorotate dehydrogenase activity
SHYC_RS08190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHYC_RS08195	COG0505	Belongs to the CarA family
SHYC_RS08205	COG0540	Belongs to the ATCase OTCase family
SHYC_RS08215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SHYC_RS08220	COG0564	pseudouridine synthase activity
SHYC_RS08225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SHYC_RS08235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SHYC_RS08240	COG3599	regulation of cell shape
SHYC_RS08250	COG0762	integral membrane protein
SHYC_RS08255	COG1799	cell septum assembly
SHYC_RS08260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SHYC_RS08265	COG1496	oxidoreductase activity
SHYC_RS08270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SHYC_RS08275	COG0849	cell division
SHYC_RS08295	COG0768	penicillin binding
SHYC_RS08300	COG4839	cell division protein FtsL
SHYC_RS08305	COG0275	rRNA processing
SHYC_RS08315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SHYC_RS08320	COG0454	-acetyltransferase
SHYC_RS08330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHYC_RS08350	COG2348	transferase activity, transferring amino-acyl groups
SHYC_RS08355	COG0739	heme binding
SHYC_RS08380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHYC_RS08385	COG1053	succinate dehydrogenase
SHYC_RS08390	COG2009	succinate dehydrogenase
SHYC_RS08395	COG0322	excinuclease ABC activity
SHYC_RS08400	COG3118	belongs to the thioredoxin family
SHYC_RS08405	COG1193	negative regulation of DNA recombination
SHYC_RS08410	COG1796	DNA polymerase
SHYC_RS08410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHYC_RS08420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SHYC_RS08425	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHYC_RS08430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHYC_RS08430	COG0072	phenylalanine-tRNA ligase activity
SHYC_RS08435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SHYC_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SHYC_RS08445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SHYC_RS08455	COG1323	Belongs to the UPF0348 family
SHYC_RS08460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHYC_RS08465	COG0742	ribosomal rna small subunit methyltransferase
SHYC_RS08475	COG4471	UPF0298 protein
SHYC_RS08485	COG3679	Belongs to the UPF0342 family
SHYC_RS08500	COG0109	protoheme IX farnesyltransferase activity
SHYC_RS08515	COG0772	Belongs to the SEDS family
SHYC_RS08520	COG4838	Belongs to the UPF0358 family
SHYC_RS08525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHYC_RS08530	COG4896	Protein conserved in bacteria
SHYC_RS08535	COG1902	pentaerythritol trinitrate reductase activity
SHYC_RS08540	COG1217	gtp-binding protein TYPA
SHYC_RS08550	COG0483	inositol monophosphate 1-phosphatase activity
SHYC_RS08555	COG4493	Belongs to the UPF0637 family
SHYC_RS08570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SHYC_RS08575	COG1177	transmembrane transport
SHYC_RS08595	COG4476	Belongs to the UPF0223 family
SHYC_RS08625	COG0242	peptide deformylase activity
SHYC_RS08635	COG5503	Protein of unknown function (DUF1447)
SHYC_RS08640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHYC_RS08650	COG0569	domain protein
SHYC_RS08655	COG1294	oxidase, subunit
SHYC_RS08660	COG1271	oxidase subunit
SHYC_RS08670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHYC_RS08685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SHYC_RS08695	COG4721	ABC-type cobalt transport system, permease component
SHYC_RS08700	COG1122	ATPase activity
SHYC_RS08710	COG0151	Belongs to the GarS family
SHYC_RS08715	COG0138	bifunctional purine biosynthesis protein purh
SHYC_RS08725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SHYC_RS08730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SHYC_RS08735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHYC_RS08745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHYC_RS08750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SHYC_RS08760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SHYC_RS08765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SHYC_RS08770	COG1017	nitric oxide dioxygenase activity
SHYC_RS08770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SHYC_RS08780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SHYC_RS08790	COG1845	cytochrome c oxidase, subunit III
SHYC_RS08805	COG1134	teichoic acid transport
SHYC_RS08825	COG0438	transferase activity, transferring glycosyl groups
SHYC_RS08830	COG1215	transferase activity, transferring glycosyl groups
SHYC_RS08850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SHYC_RS08855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHYC_RS08860	COG1316	TRANSCRIPTIONal
SHYC_RS08880	COG3594	Acyltransferase
SHYC_RS08885	COG0436	Aminotransferase
SHYC_RS08890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SHYC_RS08895	COG2267	carboxylic ester hydrolase activity
SHYC_RS08900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SHYC_RS08905	COG1169	isochorismate synthase
SHYC_RS08910	COG1575	Belongs to the MenA family. Type 1 subfamily
SHYC_RS08915	COG0390	transport system, permease component
SHYC_RS08920	COG4619	ABC transporter
SHYC_RS08965	COG4873	Protein conserved in bacteria
SHYC_RS08980	COG0737	Belongs to the 5'-nucleotidase family
SHYC_RS08985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHYC_RS08990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHYC_RS08995	COG0861	Integral membrane protein TerC family
SHYC_RS09015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SHYC_RS09020	COG2814	Major facilitator Superfamily
SHYC_RS09030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SHYC_RS09035	COG2382	esterase
SHYC_RS09040	COG1115	amino acid carrier protein
SHYC_RS09045	COG0628	permease
SHYC_RS09055	COG0475	glutathione-regulated potassium exporter activity
SHYC_RS09055	COG0569	domain protein
SHYC_RS09060	COG2239	Acts as a magnesium transporter
SHYC_RS09065	COG0564	pseudouridine synthase activity
SHYC_RS09070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHYC_RS09075	COG2357	RelA SpoT domain protein
SHYC_RS09085	COG4116	CYTH
SHYC_RS09090	COG2346	COG2346, Truncated hemoglobins
SHYC_RS09095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHYC_RS09100	COG1164	Oligoendopeptidase f
SHYC_RS09110	COG4862	establishment of competence for transformation
SHYC_RS09115	COG1393	Belongs to the ArsC family
SHYC_RS09120	COG0180	Tryptophanyl-tRNA synthetase
SHYC_RS09130	COG4608	Belongs to the ABC transporter superfamily
SHYC_RS09135	COG0444	Belongs to the ABC transporter superfamily
SHYC_RS09140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHYC_RS09145	COG0601	transmembrane transport
SHYC_RS09170	COG0542	response to heat
SHYC_RS09175	COG2151	metal-sulfur cluster biosynthetic enzyme
SHYC_RS09180	COG0561	phosphatase activity
SHYC_RS09185	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHYC_RS09195	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHYC_RS09200	COG1074	ATP-dependent DNA helicase activity
SHYC_RS09215	COG0681	Belongs to the peptidase S26 family
SHYC_RS09220	COG0166	Belongs to the GPI family
SHYC_RS09225	COG0137	argininosuccinate synthase activity
SHYC_RS09230	COG0165	Argininosuccinate lyase
SHYC_RS09235	COG0584	glycerophosphoryl diester phosphodiesterase
SHYC_RS09250	COG1012	belongs to the aldehyde dehydrogenase family
SHYC_RS09255	COG1098	S1 RNA binding domain
SHYC_RS09265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SHYC_RS09275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHYC_RS09275	COG2111	Na H antiporter
SHYC_RS09280	COG2111	Na H antiporter
SHYC_RS09285	COG1006	Multisubunit Na H antiporter MnhC subunit
SHYC_RS09290	COG0651	ATP synthesis coupled electron transport
SHYC_RS09295	COG1863	multisubunit Na H antiporter MnhE subunit
SHYC_RS09300	COG2212	antiporter activity
SHYC_RS09305	COG1320	monovalent cation:proton antiporter activity
SHYC_RS09315	COG2050	protein possibly involved in aromatic compounds catabolism
SHYC_RS09320	COG2056	Na+-H+ antiporter family
SHYC_RS09325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SHYC_RS09330	COG1252	NADH dehydrogenase
SHYC_RS09335	COG0316	Belongs to the HesB IscA family
SHYC_RS09345	COG1252	NADH dehydrogenase
SHYC_RS09350	COG4837	Protein of unknown function (DUF1462)
SHYC_RS09355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SHYC_RS09360	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SHYC_RS09370	COG1696	Membrane protein involved in D-alanine export
SHYC_RS09380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHYC_RS09390	COG2445	Protein of unknown function DUF86
SHYC_RS09400	COG4470	Protein conserved in bacteria
SHYC_RS09415	COG0730	response to heat
SHYC_RS09420	COG1801	Protein of unknown function DUF72
SHYC_RS09425	COG4536	flavin adenine dinucleotide binding
SHYC_RS09430	COG0719	Fe-S assembly protein
SHYC_RS09435	COG0822	iron-sulfur transferase activity
SHYC_RS09445	COG0719	Fe-S assembly protein
SHYC_RS09450	COG0396	ATPase activity
SHYC_RS09460	COG1464	Belongs to the NlpA lipoprotein family
SHYC_RS09465	COG2011	ABC-type metal ion transport system permease component
SHYC_RS09470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHYC_RS09475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHYC_RS09480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SHYC_RS09490	COG1393	Belongs to the ArsC family
SHYC_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHYC_RS09505	COG0710	3-dehydroquinate dehydratase activity
SHYC_RS09510	COG0456	acetyltransferase
SHYC_RS09520	COG0477	Major facilitator Superfamily
SHYC_RS09535	COG0557	exoribonuclease II activity
SHYC_RS09540	COG1647	Serine aminopeptidase, S33
SHYC_RS09545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SHYC_RS09555	COG0148	phosphopyruvate hydratase activity
SHYC_RS09560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SHYC_RS09565	COG0149	triose-phosphate isomerase activity
SHYC_RS09570	COG0126	phosphoglycerate kinase activity
SHYC_RS09595	COG1090	epimerase
SHYC_RS09620	COG1278	Cold shock
SHYC_RS09635	COG0740	serine-type endopeptidase activity
SHYC_RS09640	COG1481	regulation of sporulation
SHYC_RS09645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SHYC_RS09650	COG1660	Displays ATPase and GTPase activities
SHYC_RS09655	COG0492	ferredoxin-NADP+ reductase activity
SHYC_RS09670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SHYC_RS09675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SHYC_RS09710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SHYC_RS09715	COG0653	protein targeting
SHYC_RS09720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SHYC_RS09730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SHYC_RS09740	COG1739	Uncharacterized protein family UPF0029
SHYC_RS09745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHYC_RS09760	COG2199	diguanylate cyclase activity
SHYC_RS09775	COG2195	Cleaves the N-terminal amino acid of tripeptides
SHYC_RS09780	COG1929	Belongs to the glycerate kinase type-1 family
SHYC_RS09810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHYC_RS09815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHYC_RS09820	COG1780	Probably involved in ribonucleotide reductase function
SHYC_RS09830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SHYC_RS09835	COG3104	oligopeptide transport
SHYC_RS09855	COG1174	glycine betaine transport
SHYC_RS09860	COG1125	glycine betaine transport
SHYC_RS09860	COG0517	IMP dehydrogenase activity
SHYC_RS09865	COG0514	ATP-dependent DNA helicase (RecQ)
SHYC_RS09870	COG0488	(ABC) transporter
SHYC_RS09880	COG1368	sulfuric ester hydrolase activity
SHYC_RS09910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHYC_RS09910	COG0512	Glutamine amidotransferase of anthranilate synthase
SHYC_RS09920	COG0720	synthase
SHYC_RS09940	COG0463	Glycosyl transferase, family 2
SHYC_RS09945	COG1253	flavin adenine dinucleotide binding
SHYC_RS09950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHYC_RS09950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHYC_RS09950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHYC_RS09955	COG1105	Belongs to the carbohydrate kinase PfkB family
SHYC_RS09960	COG1349	DNA-binding transcription factor activity
SHYC_RS09965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SHYC_RS09970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHYC_RS09995	COG0039	L-malate dehydrogenase activity
SHYC_RS10005	COG4989	oxidoreductase activity
SHYC_RS10010	COG0523	cobalamin synthesis protein
SHYC_RS10020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SHYC_RS10025	COG4988	ABC transporter
SHYC_RS10030	COG1968	undecaprenyl-diphosphatase activity
SHYC_RS10055	COG1611	Belongs to the LOG family
SHYC_RS10085	COG2839	Protein conserved in bacteria
SHYC_RS10090	COG2814	Major facilitator Superfamily
SHYC_RS10095	COG0583	DNA-binding transcription factor activity
SHYC_RS10105	COG0217	transcriptional regulatory protein
SHYC_RS10115	COG2022	thiamine diphosphate biosynthetic process
SHYC_RS10120	COG2104	thiamine diphosphate biosynthetic process
SHYC_RS10120	COG2022	thiamine diphosphate biosynthetic process
SHYC_RS10135	COG3942	CHAP domain
SHYC_RS10135	COG1388	LysM domain
SHYC_RS10155	COG0306	phosphate transporter
SHYC_RS10160	COG1392	Phosphate transport regulator
SHYC_RS10165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHYC_RS10175	COG0657	acetylesterase activity
SHYC_RS10180	COG3949	Membrane
SHYC_RS10185	COG0477	Major facilitator Superfamily
SHYC_RS10195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS10200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS10205	COG1120	ATPase activity
SHYC_RS10210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SHYC_RS10215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SHYC_RS10235	COG1132	(ABC) transporter
SHYC_RS10245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SHYC_RS10250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHYC_RS10255	COG1682	transport, permease protein
SHYC_RS10260	COG1134	teichoic acid transport
SHYC_RS10265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SHYC_RS10280	COG1121	(ABC) transporter
SHYC_RS10285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SHYC_RS10290	COG0803	Belongs to the bacterial solute-binding protein 9 family
SHYC_RS10295	COG1320	monovalent cation:proton antiporter activity
SHYC_RS10300	COG2212	antiporter activity
SHYC_RS10305	COG1863	multisubunit Na H antiporter MnhE subunit
SHYC_RS10315	COG1006	Multisubunit Na H antiporter MnhC subunit
SHYC_RS10320	COG2111	Na H antiporter
SHYC_RS10325	COG2111	Na H antiporter
SHYC_RS10325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHYC_RS10330	COG0582	viral genome integration into host DNA
SHYC_RS10380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHYC_RS10385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHYC_RS10405	COG1078	dGTPase activity
SHYC_RS10415	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHYC_RS10420	COG4844	belongs to the
SHYC_RS10425	COG0471	metal ion transport
SHYC_RS10440	COG0531	amino acid
SHYC_RS10450	COG0280	phosphate acetyltransferase
SHYC_RS10455	COG0095	Lipoate-protein ligase
SHYC_RS10460	COG2814	Major facilitator Superfamily
SHYC_RS10465	COG1566	PFAM secretion protein HlyD family protein
SHYC_RS10480	COG0531	amino acid
SHYC_RS10485	COG2363	Small membrane protein
SHYC_RS10495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHYC_RS10520	COG0183	Belongs to the thiolase family
SHYC_RS10525	COG0318	PFAM AMP-dependent synthetase and ligase
SHYC_RS10535	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SHYC_RS10540	COG0363	glucosamine-6-phosphate deaminase activity
SHYC_RS10555	COG1737	Transcriptional regulator
SHYC_RS10565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHYC_RS10575	COG0431	NADPH-dependent FMN reductase
SHYC_RS10580	COG0561	phosphatase activity
SHYC_RS10590	COG1428	Deoxynucleoside kinase
SHYC_RS10595	COG1428	Deoxynucleoside kinase
SHYC_RS10615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHYC_RS10625	COG1473	amidohydrolase
SHYC_RS10640	COG0049	tRNA binding
SHYC_RS10645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SHYC_RS10655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHYC_RS10660	COG0085	RNA polymerase activity
SHYC_RS10665	COG2813	Specifically methylates the guanine in position
SHYC_RS10675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SHYC_RS10680	COG0081	regulation of translation
SHYC_RS10685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SHYC_RS10690	COG0250	Participates in transcription elongation, termination and antitermination
SHYC_RS10695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SHYC_RS10705	COG3688	RNA-binding protein containing a PIN domain
SHYC_RS10710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SHYC_RS10715	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SHYC_RS10720	COG0215	cysteine-tRNA ligase activity
SHYC_RS10745	COG4956	integral membrane protein (PIN domain superfamily)
SHYC_RS10750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SHYC_RS10760	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SHYC_RS10765	COG3880	PFAM UvrB UvrC protein
SHYC_RS10775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SHYC_RS10780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SHYC_RS10785	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SHYC_RS10790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHYC_RS10885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SHYC_RS10890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SHYC_RS10910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SHYC_RS10915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHYC_RS10930	COG1098	S1 RNA binding domain
SHYC_RS10940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SHYC_RS10945	COG3956	TIGRFAM MazG family protein
SHYC_RS10950	COG2244	polysaccharide biosynthetic process
SHYC_RS10955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SHYC_RS10960	COG0193	aminoacyl-tRNA hydrolase activity
SHYC_RS10970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHYC_RS10975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SHYC_RS10980	COG2088	sporulation resulting in formation of a cellular spore
SHYC_RS10985	COG0251	oxidation-reduction process
SHYC_RS10990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHYC_RS10995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SHYC_RS11000	COG4466	Protein conserved in bacteria
SHYC_RS11005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SHYC_RS11010	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SHYC_RS11015	COG0084	hydrolase, TatD family'
SHYC_RS11025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SHYC_RS11030	COG2827	Endonuclease containing a URI domain
SHYC_RS11035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SHYC_RS11045	COG1774	PSP1 C-terminal conserved region
SHYC_RS11050	COG0470	DNA polymerase III
SHYC_RS11055	COG3870	Protein conserved in bacteria
SHYC_RS11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SHYC_RS11065	COG1982	Orn Lys Arg decarboxylase major
SHYC_RS11090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SHYC_RS11095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SHYC_RS11100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SHYC_RS11110	COG2188	Transcriptional regulator
SHYC_RS11115	COG0366	Alpha amylase catalytic
SHYC_RS11120	COG1263	PTS System
SHYC_RS11120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SHYC_RS11130	COG0493	'glutamate synthase
SHYC_RS11135	COG0067	glutamate synthase
SHYC_RS11135	COG0070	glutamate synthase
SHYC_RS11135	COG0069	glutamate synthase activity
SHYC_RS11140	COG0583	DNA-binding transcription factor activity
SHYC_RS11155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHYC_RS11175	COG0626	cystathionine gamma-synthase activity
SHYC_RS11180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHYC_RS11190	COG2272	Belongs to the type-B carboxylesterase lipase family
SHYC_RS11195	COG0733	neurotransmitter:sodium symporter activity
SHYC_RS11200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SHYC_RS11205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHYC_RS11205	COG0574	Belongs to the PEP-utilizing enzyme family
SHYC_RS11290	COG3942	CHAP domain
SHYC_RS11290	COG1388	LysM domain
SHYC_RS11295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SHYC_RS11300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SHYC_RS11325	COG2076	Multidrug Resistance protein
SHYC_RS11330	COG2076	Multidrug Resistance protein
SHYC_RS11345	COG1124	(ABC) transporter
SHYC_RS11350	COG0444	Belongs to the ABC transporter superfamily
SHYC_RS11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHYC_RS11360	COG0601	transmembrane transport
SHYC_RS11365	COG0747	negative chemotaxis
SHYC_RS11390	COG1011	Hydrolase
SHYC_RS11410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHYC_RS11425	COG2832	Protein of unknown function (DUF454)
SHYC_RS11435	COG5492	domain, Protein
SHYC_RS11455	COG1609	Transcriptional regulator
SHYC_RS11490	COG0519	Catalyzes the synthesis of GMP from XMP
SHYC_RS11490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHYC_RS11495	COG0516	GMP reductase activity
SHYC_RS11495	COG0517	IMP dehydrogenase activity
SHYC_RS11500	COG2233	PERMEase
SHYC_RS11505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHYC_RS11525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHYC_RS11530	COG1823	symporter activity
SHYC_RS11535	COG0778	Nitroreductase
SHYC_RS11545	COG0450	alkyl hydroperoxide reductase
SHYC_RS11550	COG3634	alkyl hydroperoxide reductase activity
SHYC_RS11565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SHYC_RS11590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHYC_RS11600	COG0360	Binds together with S18 to 16S ribosomal RNA
SHYC_RS11605	COG2910	NAD(P)H-binding
SHYC_RS11610	COG0012	GTP binding
SHYC_RS11615	COG4481	Protein conserved in bacteria
SHYC_RS11620	COG0668	transmembrane transport
SHYC_RS11625	COG1475	DNA binding
SHYC_RS11630	COG0626	cystathionine gamma-synthase activity
SHYC_RS11635	COG0626	cystathionine gamma-synthase activity
SHYC_RS11640	COG0646	methionine synthase
SHYC_RS11640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SHYC_RS11660	COG1279	arginine transmembrane transporter activity
SHYC_RS11690	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SHYC_RS11695	COG2353	YceI-like domain
SHYC_RS11720	COG1846	Transcriptional regulator
SHYC_RS11725	COG0346	lactoylglutathione lyase activity
SHYC_RS11730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHYC_RS11735	COG0400	carboxylic ester hydrolase activity
SHYC_RS11745	COG0357	Ribosomal RNA small subunit methyltransferase G
SHYC_RS11750	COG0445	tRNA wobble uridine modification
SHYC_RS11755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SHYC_RS11760	COG0594	ribonuclease P activity
SHYC_RS11840	COG0587	DNA-directed DNA polymerase activity
SHYC_RS11845	COG0587	DNA-directed DNA polymerase activity
SHYC_RS11890	COG3942	CHAP domain