locus-tag	class	description
C7J89_RS00065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7J89_RS00070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C7J89_RS00080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7J89_RS00085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7J89_RS00090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7J89_RS00095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7J89_RS00110	COG1098	S1 RNA binding domain
C7J89_RS00120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7J89_RS00125	COG3956	TIGRFAM MazG family protein
C7J89_RS00130	COG2244	polysaccharide biosynthetic process
C7J89_RS00135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7J89_RS00140	COG0193	aminoacyl-tRNA hydrolase activity
C7J89_RS00145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7J89_RS00150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7J89_RS00155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7J89_RS00165	COG2088	sporulation resulting in formation of a cellular spore
C7J89_RS00170	COG0251	oxidation-reduction process
C7J89_RS00175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7J89_RS00180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7J89_RS00185	COG4466	Protein conserved in bacteria
C7J89_RS00190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7J89_RS00195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7J89_RS00200	COG0084	hydrolase, TatD family'
C7J89_RS00205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7J89_RS00205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7J89_RS00210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7J89_RS00220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7J89_RS00225	COG4467	Involved in initiation control of chromosome replication
C7J89_RS00230	COG1774	PSP1 C-terminal conserved region
C7J89_RS00235	COG0470	DNA polymerase III
C7J89_RS00240	COG3870	Protein conserved in bacteria
C7J89_RS00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7J89_RS00250	COG1982	Orn Lys Arg decarboxylase major
C7J89_RS00270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7J89_RS00275	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7J89_RS00280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7J89_RS00295	COG2188	Transcriptional regulator
C7J89_RS00300	COG0366	Alpha amylase catalytic
C7J89_RS00305	COG1263	PTS System
C7J89_RS00305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7J89_RS00315	COG0493	'glutamate synthase
C7J89_RS00320	COG0070	glutamate synthase
C7J89_RS00320	COG0069	glutamate synthase activity
C7J89_RS00320	COG0067	glutamate synthase
C7J89_RS00340	COG0004	ammonium transporteR
C7J89_RS00355	COG3942	CHAP domain
C7J89_RS00355	COG1388	LysM domain
C7J89_RS00365	COG2011	ABC-type metal ion transport system permease component
C7J89_RS00370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7J89_RS00390	COG0733	neurotransmitter:sodium symporter activity
C7J89_RS00420	COG1114	Component of the transport system for branched-chain amino acids
C7J89_RS00440	COG2807	transmembrane transport
C7J89_RS00445	COG2814	Major facilitator Superfamily
C7J89_RS00465	COG0583	DNA-binding transcription factor activity
C7J89_RS00470	COG2610	gluconate transmembrane transporter activity
C7J89_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS00525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7J89_RS00525	COG0519	Catalyzes the synthesis of GMP from XMP
C7J89_RS00530	COG0517	IMP dehydrogenase activity
C7J89_RS00530	COG0516	GMP reductase activity
C7J89_RS00535	COG2233	PERMEase
C7J89_RS00540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7J89_RS00560	COG1823	symporter activity
C7J89_RS00570	COG0778	Nitroreductase
C7J89_RS00575	COG0450	alkyl hydroperoxide reductase
C7J89_RS00580	COG3634	alkyl hydroperoxide reductase activity
C7J89_RS00610	COG2348	transferase activity, transferring amino-acyl groups
C7J89_RS00620	COG3623	hexulose-6-phosphate isomerase
C7J89_RS00650	COG2076	Multidrug Resistance protein
C7J89_RS00655	COG2076	Multidrug Resistance protein
C7J89_RS00670	COG1764	response to oxidative stress
C7J89_RS00675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7J89_RS00690	COG2814	Major facilitator Superfamily
C7J89_RS00700	COG0346	lactoylglutathione lyase activity
C7J89_RS00745	COG1695	Transcriptional regulator
C7J89_RS00765	COG2843	Capsule synthesis protein
C7J89_RS00775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7J89_RS00810	COG0640	Transcriptional regulator
C7J89_RS00820	COG0346	lactoylglutathione lyase activity
C7J89_RS00845	COG0583	DNA-binding transcription factor activity
C7J89_RS00855	COG2814	Major facilitator Superfamily
C7J89_RS00865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7J89_RS00865	COG2207	Transcriptional regulator
C7J89_RS00870	COG1486	melibiose metabolic process
C7J89_RS00875	COG2211	Major facilitator Superfamily
C7J89_RS00880	COG0596	Alpha beta hydrolase
C7J89_RS00890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS00895	COG1388	LysM domain
C7J89_RS00905	COG1113	amino acid transport
C7J89_RS00925	COG1733	regulation of RNA biosynthetic process
C7J89_RS00930	COG0577	efflux transmembrane transporter activity
C7J89_RS00930	COG1136	(ABC) transporter
C7J89_RS00935	COG1136	(ABC) transporter
C7J89_RS00965	COG0740	serine-type endopeptidase activity
C7J89_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS01015	COG1846	Transcriptional regulator
C7J89_RS01020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7J89_RS01030	COG0360	Binds together with S18 to 16S ribosomal RNA
C7J89_RS01050	COG0012	GTP binding
C7J89_RS01055	COG4481	Protein conserved in bacteria
C7J89_RS01060	COG0668	transmembrane transport
C7J89_RS01070	COG0604	alcohol dehydrogenase
C7J89_RS01120	COG1063	alcohol dehydrogenase
C7J89_RS01125	COG0477	Major facilitator Superfamily
C7J89_RS01135	COG1136	(ABC) transporter
C7J89_RS01140	COG0191	fructose-bisphosphate aldolase activity
C7J89_RS01145	COG3962	Belongs to the TPP enzyme family
C7J89_RS01150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7J89_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS01165	COG1349	DNA-binding transcription factor activity
C7J89_RS01170	COG0673	inositol 2-dehydrogenase activity
C7J89_RS01180	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7J89_RS01185	COG0673	inositol 2-dehydrogenase activity
C7J89_RS01215	COG1346	cytolysis
C7J89_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS01225	COG1475	DNA binding
C7J89_RS01235	COG0626	cystathionine gamma-synthase activity
C7J89_RS01240	COG0626	cystathionine gamma-synthase activity
C7J89_RS01245	COG0646	methionine synthase
C7J89_RS01245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7J89_RS01250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7J89_RS01260	COG2314	TM2 domain
C7J89_RS01265	COG1966	Carbon starvation protein
C7J89_RS01270	COG2807	transmembrane transport
C7J89_RS01275	COG1476	TRANSCRIPTIONal
C7J89_RS01280	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C7J89_RS01290	COG0583	DNA-binding transcription factor activity
C7J89_RS01300	COG0598	Magnesium transport protein CorA
C7J89_RS01320	COG0191	fructose-bisphosphate aldolase activity
C7J89_RS01325	COG2610	gluconate transmembrane transporter activity
C7J89_RS01335	COG2084	Dehydrogenase
C7J89_RS01345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7J89_RS01365	COG0577	efflux transmembrane transporter activity
C7J89_RS01365	COG1136	(ABC) transporter
C7J89_RS01370	COG1136	(ABC) transporter
C7J89_RS01375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7J89_RS01380	COG0583	DNA-binding transcription factor activity
C7J89_RS01395	COG0471	metal ion transport
C7J89_RS01420	COG1957	nucleoside hydrolase
C7J89_RS01440	COG1475	DNA binding
C7J89_RS01445	COG0357	Ribosomal RNA small subunit methyltransferase G
C7J89_RS01450	COG0445	tRNA wobble uridine modification
C7J89_RS01455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7J89_RS01460	COG0594	ribonuclease P activity
C7J89_RS01470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7J89_RS01475	COG0592	DNA-directed DNA polymerase activity
C7J89_RS01490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7J89_RS01495	COG0187	DNA topoisomerase II activity
C7J89_RS01500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7J89_RS01505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7J89_RS01510	COG2986	histidine ammonia-lyase
C7J89_RS01515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7J89_RS01530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7J89_RS01540	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C7J89_RS01545	COG0359	binds to the 23S rRNA
C7J89_RS01550	COG0305	Participates in initiation and elongation during chromosome replication
C7J89_RS01555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7J89_RS01560	COG1819	glycosyl
C7J89_RS01585	COG0745	RESPONSE REGULATOR receiver
C7J89_RS01590	COG5002	protein histidine kinase activity
C7J89_RS01595	COG4863	YycH protein
C7J89_RS01610	COG1063	alcohol dehydrogenase
C7J89_RS01615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C7J89_RS01620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7J89_RS01630	COG1388	LysM domain
C7J89_RS01635	COG0730	response to heat
C7J89_RS01640	COG1937	Protein conserved in bacteria
C7J89_RS01645	COG2210	Belongs to the sulfur carrier protein TusA family
C7J89_RS01650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7J89_RS01660	COG1695	Transcriptional regulator
C7J89_RS01665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7J89_RS01670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C7J89_RS01680	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7J89_RS01695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C7J89_RS01700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7J89_RS01705	COG0640	Transcriptional regulator
C7J89_RS01750	COG1876	peptidase activity
C7J89_RS01765	COG2720	vancomycin resistance protein
C7J89_RS01770	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C7J89_RS01780	COG0471	metal ion transport
C7J89_RS01785	COG1064	alcohol dehydrogenase
C7J89_RS01795	COG1959	2 iron, 2 sulfur cluster binding
C7J89_RS01800	COG2910	NAD(P)H-binding
C7J89_RS01805	COG1114	Component of the transport system for branched-chain amino acids
C7J89_RS01810	COG0463	Glycosyl transferase, family 2
C7J89_RS01810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7J89_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS01820	COG2814	Major facilitator Superfamily
C7J89_RS01830	COG0833	amino acid
C7J89_RS01835	COG2040	homocysteine
C7J89_RS01840	COG0405	Gamma-glutamyltransferase
C7J89_RS01850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7J89_RS01855	COG0601	transmembrane transport
C7J89_RS01860	COG4172	Belongs to the ABC transporter superfamily
C7J89_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS01890	COG0659	secondary active sulfate transmembrane transporter activity
C7J89_RS01910	COG1869	D-ribose catabolic process
C7J89_RS01935	COG1846	Transcriptional regulator
C7J89_RS01950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C7J89_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS01960	COG0583	DNA-binding transcription factor activity
C7J89_RS01995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7J89_RS02000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C7J89_RS02005	COG0463	Glycosyl transferase, family 2
C7J89_RS02010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7J89_RS02010	COG0463	Glycosyl transferase, family 2
C7J89_RS02015	COG2807	transmembrane transport
C7J89_RS02020	COG0697	spore germination
C7J89_RS02025	COG2207	Transcriptional regulator
C7J89_RS02030	COG2814	Major facilitator Superfamily
C7J89_RS02040	COG1846	Transcriptional regulator
C7J89_RS02045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7J89_RS02050	COG0386	Belongs to the glutathione peroxidase family
C7J89_RS02080	COG4221	oxidoreductase activity
C7J89_RS02085	COG3314	Sporulation integral membrane protein YlbJ
C7J89_RS02090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C7J89_RS02095	COG2409	Drug exporters of the RND superfamily
C7J89_RS02115	COG1609	Transcriptional regulator
C7J89_RS02125	COG0235	Class ii aldolase
C7J89_RS02130	COG2160	L-arabinose isomerase activity
C7J89_RS02140	COG1309	transcriptional regulator
C7J89_RS02170	COG1755	Isoprenylcysteine carboxyl methyltransferase
C7J89_RS02190	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS02195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7J89_RS02205	COG2271	Major facilitator Superfamily
C7J89_RS02215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7J89_RS02215	COG0456	acetyltransferase
C7J89_RS02220	COG0039	L-malate dehydrogenase activity
C7J89_RS02225	COG3620	sequence-specific DNA binding
C7J89_RS02230	COG0477	Major facilitator Superfamily
C7J89_RS02235	COG0584	glycerophosphoryl diester phosphodiesterase
C7J89_RS02240	COG2207	Transcriptional regulator
C7J89_RS02245	COG2211	Major facilitator Superfamily
C7J89_RS02250	COG3250	beta-galactosidase activity
C7J89_RS02255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7J89_RS02260	COG2226	methyltransferase
C7J89_RS02265	COG2851	Citrate transporter
C7J89_RS02270	COG1285	pathogenesis
C7J89_RS02285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7J89_RS02290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7J89_RS02300	COG0579	oxidoreductase
C7J89_RS02315	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7J89_RS02320	COG0668	transmembrane transport
C7J89_RS02325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7J89_RS02335	COG0702	epimerase
C7J89_RS02340	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7J89_RS02360	COG1233	COG1233 Phytoene dehydrogenase and related
C7J89_RS02365	COG3871	stress protein (general stress protein 26)
C7J89_RS02375	COG0415	Belongs to the DNA photolyase family
C7J89_RS02380	COG1388	LysM domain
C7J89_RS02385	COG0402	S-adenosylhomocysteine deaminase activity
C7J89_RS02395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C7J89_RS02410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C7J89_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS02445	COG1054	Belongs to the UPF0176 family
C7J89_RS02455	COG0402	S-adenosylhomocysteine deaminase activity
C7J89_RS02465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS02470	COG4605	iron ion homeostasis
C7J89_RS02475	COG4604	ABC transporter, ATP-binding protein
C7J89_RS02480	COG4607	ABC-type enterochelin transport system periplasmic component
C7J89_RS02485	COG3189	MarR family transcriptional regulator
C7J89_RS02500	COG1595	DNA-templated transcription, initiation
C7J89_RS02515	COG3682	Transcriptional regulator
C7J89_RS02565	COG2832	Protein of unknown function (DUF454)
C7J89_RS02570	COG0346	lactoylglutathione lyase activity
C7J89_RS02580	COG0406	alpha-ribazole phosphatase activity
C7J89_RS02585	COG4106	trans-aconitate 2-methyltransferase activity
C7J89_RS02595	COG3942	CHAP domain
C7J89_RS02610	COG3386	PFAM SMP-30 Gluconolaconase
C7J89_RS02615	COG1288	antiporter activity
C7J89_RS02635	COG1131	(ABC) transporter
C7J89_RS02655	COG0737	Belongs to the 5'-nucleotidase family
C7J89_RS02660	COG0129	dihydroxy-acid dehydratase activity
C7J89_RS02665	COG1113	amino acid transport
C7J89_RS02670	COG0753	catalase activity
C7J89_RS02675	COG0183	Belongs to the thiolase family
C7J89_RS02680	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7J89_RS02680	COG1024	Enoyl-CoA hydratase
C7J89_RS02685	COG1960	acyl-CoA dehydrogenase activity
C7J89_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS02705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS02710	COG0531	amino acid
C7J89_RS02715	COG1279	arginine transmembrane transporter activity
C7J89_RS02720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7J89_RS02740	COG0583	DNA-binding transcription factor activity
C7J89_RS02765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7J89_RS02770	COG3002	Belongs to the UPF0753 family
C7J89_RS02775	COG5609	conserved protein (DUF2294)
C7J89_RS02780	COG0477	Major facilitator Superfamily
C7J89_RS02790	COG2814	Major facilitator Superfamily
C7J89_RS02795	COG0583	DNA-binding transcription factor activity
C7J89_RS02810	COG3192	ethanolamine utilization protein
C7J89_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS02825	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS02830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7J89_RS02835	COG0175	sulfate reduction
C7J89_RS02840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C7J89_RS02845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7J89_RS02865	COG0730	response to heat
C7J89_RS02870	COG2046	Belongs to the sulfate adenylyltransferase family
C7J89_RS02875	COG0529	Catalyzes the synthesis of activated sulfate
C7J89_RS02880	COG1017	nitric oxide dioxygenase activity
C7J89_RS02880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7J89_RS02890	COG0730	response to heat
C7J89_RS02895	COG0778	Nitroreductase
C7J89_RS02900	COG1473	amidohydrolase
C7J89_RS02915	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
C7J89_RS02920	COG1691	(AIR) carboxylase
C7J89_RS02925	COG1606	tRNA processing
C7J89_RS02930	COG3875	lactate racemase activity
C7J89_RS02950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7J89_RS02950	COG0574	Belongs to the PEP-utilizing enzyme family
C7J89_RS02955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7J89_RS02960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7J89_RS02965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7J89_RS02970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C7J89_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS02980	COG3588	fructose-bisphosphate aldolase
C7J89_RS02985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7J89_RS02995	COG1510	regulation of RNA biosynthetic process
C7J89_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS03005	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7J89_RS03020	COG0477	Major facilitator Superfamily
C7J89_RS03030	COG2271	Major facilitator Superfamily
C7J89_RS03035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7J89_RS03045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7J89_RS03055	COG1957	nucleoside hydrolase
C7J89_RS03065	COG0477	Major facilitator Superfamily
C7J89_RS03070	COG0531	amino acid
C7J89_RS03075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7J89_RS03080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7J89_RS03085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C7J89_RS03090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7J89_RS03095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7J89_RS03100	COG1070	Carbohydrate kinase
C7J89_RS03105	COG0352	thiamine-phosphate diphosphorylase activity
C7J89_RS03110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7J89_RS03120	COG2022	thiamine diphosphate biosynthetic process
C7J89_RS03125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7J89_RS03130	COG2814	Major facilitator Superfamily
C7J89_RS03145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7J89_RS03150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7J89_RS03155	COG1846	Transcriptional regulator
C7J89_RS03155	COG1940	carbohydrate kinase activity
C7J89_RS03160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7J89_RS03175	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7J89_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7J89_RS03185	COG0765	amino acid transport
C7J89_RS03190	COG1126	abc transporter atp-binding protein
C7J89_RS03195	COG3711	transcriptional antiterminator
C7J89_RS03200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7J89_RS03215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7J89_RS03220	COG1482	cell wall glycoprotein biosynthetic process
C7J89_RS03245	COG0626	cystathionine gamma-synthase activity
C7J89_RS03250	COG1131	(ABC) transporter
C7J89_RS03260	COG1309	transcriptional regulator
C7J89_RS03270	COG0829	nickel cation binding
C7J89_RS03275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C7J89_RS03280	COG0830	nickel cation binding
C7J89_RS03290	COG0804	urea catabolic process
C7J89_RS03295	COG0832	Belongs to the urease beta subunit family
C7J89_RS03300	COG0831	urea catabolic process
C7J89_RS03310	COG0747	negative chemotaxis
C7J89_RS03335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7J89_RS03350	COG0561	phosphatase activity
C7J89_RS03360	COG0167	dihydroorotate dehydrogenase activity
C7J89_RS03365	COG3001	Fructosamine kinase
C7J89_RS03400	COG1388	LysM domain
C7J89_RS03405	COG0436	Aminotransferase
C7J89_RS03410	COG2608	mercury ion transmembrane transporter activity
C7J89_RS03415	COG2217	Heavy metal translocating P-type atpase
C7J89_RS03420	COG1136	(ABC) transporter
C7J89_RS03425	COG0577	efflux transmembrane transporter activity
C7J89_RS03435	COG0471	metal ion transport
C7J89_RS03440	COG5505	Protein of unknown function (DUF819)
C7J89_RS03450	COG4336	lyase activity
C7J89_RS03465	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C7J89_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS03480	COG3961	Belongs to the TPP enzyme family
C7J89_RS03490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7J89_RS03495	COG3425	synthase
C7J89_RS03510	COG3942	CHAP domain
C7J89_RS03510	COG1388	LysM domain
C7J89_RS03515	COG0583	DNA-binding transcription factor activity
C7J89_RS03520	COG1380	Effector of murein hydrolase LrgA
C7J89_RS03530	COG0028	Belongs to the TPP enzyme family
C7J89_RS03535	COG1288	antiporter activity
C7J89_RS03560	COG1247	-acetyltransferase
C7J89_RS03565	COG0657	acetylesterase activity
C7J89_RS03585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7J89_RS03590	COG1063	alcohol dehydrogenase
C7J89_RS03595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7J89_RS03620	COG3764	Sortase (surface protein transpeptidase)
C7J89_RS03635	COG2190	(PTS) system
C7J89_RS03635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7J89_RS03635	COG1263	PTS System
C7J89_RS03640	COG0363	glucosamine-6-phosphate deaminase activity
C7J89_RS03650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7J89_RS03655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7J89_RS03660	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7J89_RS03665	COG0561	phosphatase activity
C7J89_RS03670	COG0778	Nitroreductase
C7J89_RS03680	COG2514	catechol 2,3-dioxygenase activity
C7J89_RS03685	COG1132	(ABC) transporter
C7J89_RS03690	COG1132	(ABC) transporter
C7J89_RS03705	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS03710	COG1846	Transcriptional regulator
C7J89_RS03715	COG0346	lactoylglutathione lyase activity
C7J89_RS03720	COG0346	lactoylglutathione lyase activity
C7J89_RS03725	COG0400	carboxylic ester hydrolase activity
C7J89_RS03730	COG1335	isochorismatase
C7J89_RS03735	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C7J89_RS03740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7J89_RS03745	COG0444	Belongs to the ABC transporter superfamily
C7J89_RS03755	COG0586	Pfam SNARE associated Golgi protein
C7J89_RS03760	COG2271	Major facilitator Superfamily
C7J89_RS03770	COG3527	Alpha-acetolactate decarboxylase
C7J89_RS03780	COG4876	unkown
C7J89_RS03785	COG2808	Putative FMN-binding domain
C7J89_RS03790	COG2357	RelA SpoT domain protein
C7J89_RS03795	COG1802	Transcriptional regulator
C7J89_RS03800	COG1070	Carbohydrate kinase
C7J89_RS03805	COG2610	gluconate transmembrane transporter activity
C7J89_RS03810	COG2207	Transcriptional regulator
C7J89_RS03815	COG2211	Major facilitator Superfamily
C7J89_RS03820	COG3250	beta-galactosidase activity
C7J89_RS03830	COG4221	oxidoreductase activity
C7J89_RS03840	COG0107	imidazoleglycerol-phosphate synthase activity
C7J89_RS03845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7J89_RS03850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7J89_RS03860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7J89_RS03865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7J89_RS03870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7J89_RS03880	COG3048	D-serine ammonia-lyase activity
C7J89_RS03885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C7J89_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS03895	COG1363	Peptidase, m42
C7J89_RS03900	COG0069	glutamate synthase activity
C7J89_RS03905	COG4619	ABC transporter
C7J89_RS03910	COG0390	transport system, permease component
C7J89_RS03915	COG2814	Major facilitator Superfamily
C7J89_RS03920	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C7J89_RS03925	COG1309	transcriptional regulator
C7J89_RS03930	COG3246	L-lysine catabolic process to acetate
C7J89_RS03935	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7J89_RS03960	COG1174	glycine betaine transport
C7J89_RS03975	COG4187	Peptidase family M20/M25/M40
C7J89_RS03990	COG0025	NhaP-type Na H and K H
C7J89_RS04010	COG2814	Major facilitator Superfamily
C7J89_RS04015	COG1929	Belongs to the glycerate kinase type-1 family
C7J89_RS04030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C7J89_RS04035	COG0741	lytic transglycosylase activity
C7J89_RS04040	COG0588	phosphoglycerate mutase activity
C7J89_RS04050	COG2814	Major facilitator Superfamily
C7J89_RS04075	COG2353	YceI-like domain
C7J89_RS04090	COG2723	6-phospho-beta-galactosidase activity
C7J89_RS04095	COG2190	(PTS) system
C7J89_RS04095	COG1263	PTS System
C7J89_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7J89_RS04100	COG2188	Transcriptional regulator
C7J89_RS04105	COG1959	2 iron, 2 sulfur cluster binding
C7J89_RS04110	COG2116	formate transmembrane transporter activity
C7J89_RS04115	COG0454	-acetyltransferase
C7J89_RS04120	COG0071	Belongs to the small heat shock protein (HSP20) family
C7J89_RS04125	COG1846	Transcriptional regulator
C7J89_RS04170	COG1283	sodium-dependent phosphate transmembrane transporter activity
C7J89_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS04180	COG1349	DNA-binding transcription factor activity
C7J89_RS04185	COG1063	alcohol dehydrogenase
C7J89_RS04190	COG2376	Dihydroxyacetone kinase
C7J89_RS04200	COG0698	ribose 5-phosphate isomerase
C7J89_RS04210	COG4549	nuclear export factor GLE1
C7J89_RS04220	COG0492	ferredoxin-NADP+ reductase activity
C7J89_RS04235	COG0730	response to heat
C7J89_RS04240	COG2814	Major facilitator Superfamily
C7J89_RS04245	COG0604	alcohol dehydrogenase
C7J89_RS04260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7J89_RS04275	COG3850	Histidine kinase
C7J89_RS04275	COG5002	protein histidine kinase activity
C7J89_RS04280	COG0745	RESPONSE REGULATOR receiver
C7J89_RS04285	COG0577	efflux transmembrane transporter activity
C7J89_RS04290	COG1136	(ABC) transporter
C7J89_RS04305	COG1033	growth of symbiont in host cell
C7J89_RS04305	COG2409	Drug exporters of the RND superfamily
C7J89_RS04310	COG4640	response to antibiotic
C7J89_RS04315	COG2814	Major facilitator Superfamily
C7J89_RS04325	COG1566	PFAM secretion protein HlyD family protein
C7J89_RS04330	COG2814	Major facilitator Superfamily
C7J89_RS04355	COG0598	Magnesium transport protein CorA
C7J89_RS04360	COG1304	FMN binding
C7J89_RS04365	COG0786	glutamate:sodium symporter activity
C7J89_RS04370	COG1757	Na H antiporter
C7J89_RS04375	COG2094	Belongs to the DNA glycosylase MPG family
C7J89_RS04380	COG3152	Membrane
C7J89_RS04385	COG1069	ribulokinase activity
C7J89_RS04390	COG4152	abc transporter atp-binding protein
C7J89_RS04395	COG1668	transmembrane transport
C7J89_RS04400	COG2017	converts alpha-aldose to the beta-anomer
C7J89_RS04405	COG2258	MOSC domain
C7J89_RS04410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7J89_RS04415	COG1266	CAAX protease self-immunity
C7J89_RS04420	COG0010	Belongs to the arginase family
C7J89_RS04430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C7J89_RS04435	COG1228	amidohydrolase
C7J89_RS04440	COG0659	secondary active sulfate transmembrane transporter activity
C7J89_RS04445	COG1473	amidohydrolase
C7J89_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS04455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C7J89_RS04470	COG1737	Transcriptional regulator
C7J89_RS04475	COG1263	PTS System
C7J89_RS04475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7J89_RS04485	COG0385	Bile acid
C7J89_RS04490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7J89_RS04510	COG1113	amino acid transport
C7J89_RS04515	COG1737	Transcriptional regulator
C7J89_RS04525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7J89_RS04545	COG1349	DNA-binding transcription factor activity
C7J89_RS04550	COG0483	inositol monophosphate 1-phosphatase activity
C7J89_RS04555	COG1316	TRANSCRIPTIONal
C7J89_RS04560	COG3383	formate dehydrogenase (NAD+) activity
C7J89_RS04590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7J89_RS04595	COG2076	Multidrug Resistance protein
C7J89_RS04600	COG2076	Multidrug Resistance protein
C7J89_RS04605	COG3942	CHAP domain
C7J89_RS04620	COG1757	Na H antiporter
C7J89_RS04625	COG3942	CHAP domain
C7J89_RS04640	COG1960	acyl-CoA dehydrogenase activity
C7J89_RS04650	COG1268	BioY protein
C7J89_RS04660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7J89_RS04665	COG1609	Transcriptional regulator
C7J89_RS04670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7J89_RS04675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7J89_RS04680	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7J89_RS04685	COG0725	ABC transporter, periplasmic molybdate-binding protein
C7J89_RS04690	COG4149	molybdate abc transporter
C7J89_RS04705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7J89_RS04715	COG0315	cyclic pyranopterin monophosphate synthase activity
C7J89_RS04725	COG1763	Mo-molybdopterin cofactor biosynthetic process
C7J89_RS04730	COG0314	molybdopterin synthase activity
C7J89_RS04740	COG0746	molybdenum cofactor guanylyltransferase activity
C7J89_RS04745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7J89_RS04755	COG2814	Major facilitator Superfamily
C7J89_RS04775	COG2348	transferase activity, transferring amino-acyl groups
C7J89_RS04780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C7J89_RS04800	COG4975	Glucose uptake
C7J89_RS04810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7J89_RS04810	COG0551	DNA topoisomerase type I activity
C7J89_RS04815	COG2252	PERMEase
C7J89_RS04830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7J89_RS04835	COG0088	Forms part of the polypeptide exit tunnel
C7J89_RS04840	COG0089	rRNA binding
C7J89_RS04845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7J89_RS04850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7J89_RS04855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7J89_RS04860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7J89_RS04865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7J89_RS04870	COG0255	Belongs to the universal ribosomal protein uL29 family
C7J89_RS04875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7J89_RS04880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7J89_RS04885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7J89_RS04890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7J89_RS04895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7J89_RS04900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7J89_RS04905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7J89_RS04910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7J89_RS04915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7J89_RS04920	COG1841	ribosomal large subunit assembly
C7J89_RS04930	COG0201	protein transport
C7J89_RS04945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7J89_RS04950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7J89_RS04955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7J89_RS04960	COG0202	RNA polymerase activity
C7J89_RS04965	COG0203	ribosomal protein L17
C7J89_RS04970	COG1122	ATPase activity
C7J89_RS04975	COG1122	ATPase activity
C7J89_RS04985	COG0101	tRNA pseudouridine synthase activity
C7J89_RS04990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7J89_RS04995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7J89_RS05000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS05005	COG2130	NADP-dependent
C7J89_RS05010	COG0604	alcohol dehydrogenase
C7J89_RS05025	COG1302	Protein conserved in bacteria
C7J89_RS05035	COG2814	Major facilitator Superfamily
C7J89_RS05040	COG4264	IucA IucC family
C7J89_RS05045	COG3457	Alanine racemase
C7J89_RS05050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C7J89_RS05055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS05060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS05065	COG3314	Sporulation integral membrane protein YlbJ
C7J89_RS05070	COG2329	Antibiotic biosynthesis monooxygenase
C7J89_RS05080	COG1988	membrane-bound metal-dependent
C7J89_RS05085	COG4284	Utp--glucose-1-phosphate uridylyltransferase
C7J89_RS05090	COG1272	protein, Hemolysin III
C7J89_RS05105	COG2814	Major facilitator Superfamily
C7J89_RS05110	COG0489	protein tyrosine kinase activity
C7J89_RS05165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C7J89_RS05175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7J89_RS05180	COG0246	Mannitol dehydrogenase
C7J89_RS05190	COG3711	transcriptional antiterminator
C7J89_RS05205	COG1119	ATPase activity
C7J89_RS05210	COG0561	phosphatase activity
C7J89_RS05230	COG0640	Transcriptional regulator
C7J89_RS05235	COG0702	epimerase
C7J89_RS05240	COG2186	Transcriptional regulator
C7J89_RS05245	COG1482	cell wall glycoprotein biosynthetic process
C7J89_RS05265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7J89_RS05270	COG0783	Belongs to the Dps family
C7J89_RS05275	COG0813	purine-nucleoside phosphorylase activity
C7J89_RS05280	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7J89_RS05285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7J89_RS05290	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7J89_RS05300	COG1854	S-ribosylhomocysteine lyase activity
C7J89_RS05320	COG5146	pantothenate kinase activity
C7J89_RS05330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7J89_RS05340	COG0504	CTP synthase activity
C7J89_RS05350	COG0191	fructose-bisphosphate aldolase activity
C7J89_RS05355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7J89_RS05365	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS05370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7J89_RS05375	COG0254	rRNA binding
C7J89_RS05380	COG1435	thymidine kinase activity
C7J89_RS05385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7J89_RS05390	COG2890	protein-(glutamine-N5) methyltransferase activity
C7J89_RS05395	COG0009	L-threonylcarbamoyladenylate synthase
C7J89_RS05400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7J89_RS05405	COG4475	Protein of unknown function (DUF436)
C7J89_RS05410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7J89_RS05415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7J89_RS05420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7J89_RS05430	COG0356	it plays a direct role in the translocation of protons across the membrane
C7J89_RS05435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7J89_RS05440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7J89_RS05445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7J89_RS05450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7J89_RS05455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7J89_RS05460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7J89_RS05465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7J89_RS05470	COG4836	Membrane
C7J89_RS05475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7J89_RS05490	COG0629	single-stranded DNA binding
C7J89_RS05495	COG1388	LysM domain
C7J89_RS05500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C7J89_RS05510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C7J89_RS05515	COG0352	thiamine-phosphate diphosphorylase activity
C7J89_RS05520	COG0706	membrane insertase activity
C7J89_RS05525	COG1418	mRNA catabolic process
C7J89_RS05535	COG1937	Protein conserved in bacteria
C7J89_RS05550	COG0772	Belongs to the SEDS family
C7J89_RS05555	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7J89_RS05560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7J89_RS05565	COG0513	Belongs to the DEAD box helicase family
C7J89_RS05590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7J89_RS05600	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7J89_RS05605	COG2208	phosphoserine phosphatase activity
C7J89_RS05620	COG1191	sigma factor activity
C7J89_RS05625	COG2183	response to ionizing radiation
C7J89_RS05630	COG3091	SprT-like family
C7J89_RS05660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7J89_RS05665	COG0066	3-isopropylmalate dehydratase activity
C7J89_RS05670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7J89_RS05675	COG0473	3-isopropylmalate dehydrogenase activity
C7J89_RS05680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7J89_RS05685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7J89_RS05690	COG0440	acetolactate synthase activity
C7J89_RS05695	COG0028	Belongs to the TPP enzyme family
C7J89_RS05700	COG0129	dihydroxy-acid dehydratase activity
C7J89_RS05705	COG0802	atpase or kinase
C7J89_RS05710	COG1214	PFAM Peptidase M22, glycoprotease
C7J89_RS05715	COG0456	acetyltransferase
C7J89_RS05720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7J89_RS05735	COG0488	(ABC) transporter
C7J89_RS05740	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7J89_RS05745	COG2391	methyltransferase activity
C7J89_RS05750	COG0425	Belongs to the sulfur carrier protein TusA family
C7J89_RS05755	COG1621	beta-fructofuranosidase activity
C7J89_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7J89_RS05765	COG3279	Response regulator of the LytR AlgR family
C7J89_RS05780	COG4512	PFAM Accessory gene regulator B
C7J89_RS05805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7J89_RS05810	COG0459	protein refolding
C7J89_RS05825	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C7J89_RS05835	COG1131	(ABC) transporter
C7J89_RS05875	COG1280	lysine exporter protein (LysE YggA)
C7J89_RS05890	COG2706	6-phosphogluconolactonase activity
C7J89_RS05895	COG1012	belongs to the aldehyde dehydrogenase family
C7J89_RS05900	COG1227	inorganic diphosphatase activity
C7J89_RS05905	COG1335	isochorismatase
C7J89_RS05920	COG0077	Prephenate dehydratase
C7J89_RS05930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7J89_RS05935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7J89_RS05940	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C7J89_RS05955	COG4496	protein, YerC YecD
C7J89_RS05975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7J89_RS05985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7J89_RS05990	COG0154	amidase activity
C7J89_RS05995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7J89_RS06000	COG1597	lipid kinase activity
C7J89_RS06015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7J89_RS06025	COG1528	Iron-storage protein
C7J89_RS06040	COG4129	membrane
C7J89_RS06045	COG0024	Methionine aminopeptidase
C7J89_RS06060	COG4585	Histidine kinase
C7J89_RS06065	COG2197	response regulator
C7J89_RS06070	COG1295	ribonuclease BN
C7J89_RS06085	COG4840	Belongs to the UPF0435 family
C7J89_RS06090	COG2309	aminopeptidase activity
C7J89_RS06095	COG1607	acyl-coa hydrolase
C7J89_RS06100	COG0535	radical SAM domain protein
C7J89_RS06110	COG0693	protein deglycase activity
C7J89_RS06115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7J89_RS06120	COG2137	regulation of response to DNA damage stimulus
C7J89_RS06130	COG1134	teichoic acid transport
C7J89_RS06130	COG1388	LysM domain
C7J89_RS06140	COG1988	membrane-bound metal-dependent
C7J89_RS06145	COG1194	a g-specific adenine glycosylase
C7J89_RS06150	COG3557	Belongs to the UPF0374 family
C7J89_RS06160	COG4129	membrane
C7J89_RS06165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7J89_RS06170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7J89_RS06175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7J89_RS06180	COG0735	belongs to the Fur family
C7J89_RS06335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7J89_RS06380	COG0556	nucleotide-excision repair
C7J89_RS06445	COG0756	dUTP diphosphatase activity
C7J89_RS06505	COG0740	serine-type endopeptidase activity
C7J89_RS06600	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7J89_RS06600	COG1388	LysM domain
C7J89_RS06625	COG0730	response to heat
C7J89_RS06635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS06640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7J89_RS06645	COG0531	amino acid
C7J89_RS06655	COG0765	amino acid transport
C7J89_RS06660	COG1126	abc transporter atp-binding protein
C7J89_RS06665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7J89_RS06675	COG0363	glucosamine-6-phosphate deaminase activity
C7J89_RS06690	COG0114	fumarate hydratase activity
C7J89_RS06695	COG0564	pseudouridine synthase activity
C7J89_RS06700	COG2203	Gaf domain
C7J89_RS06700	COG4585	Histidine kinase
C7J89_RS06705	COG2197	response regulator
C7J89_RS06715	COG0788	formyltetrahydrofolate deformylase activity
C7J89_RS06725	COG4399	Belongs to the UPF0754 family
C7J89_RS06730	COG3679	Belongs to the UPF0342 family
C7J89_RS06735	COG0420	3'-5' exonuclease activity
C7J89_RS06740	COG4717	serine-type aminopeptidase activity
C7J89_RS06745	COG3481	metal-dependent phosphohydrolase, HD sub domain
C7J89_RS06750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7J89_RS06765	COG0537	adenosine 5'-monophosphoramidase activity
C7J89_RS06770	COG1131	(ABC) transporter
C7J89_RS06775	COG4473	ABC transporter
C7J89_RS06785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7J89_RS06790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7J89_RS06795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C7J89_RS06855	COG0519	Catalyzes the synthesis of GMP from XMP
C7J89_RS06935	COG0110	maltose O-acetyltransferase activity
C7J89_RS06950	COG0438	transferase activity, transferring glycosyl groups
C7J89_RS06950	COG0297	glycogen (starch) synthase activity
C7J89_RS06955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7J89_RS06960	COG0110	maltose O-acetyltransferase activity
C7J89_RS06965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7J89_RS06970	COG1917	Cupin 2, conserved barrel domain protein
C7J89_RS06970	COG2207	Transcriptional regulator
C7J89_RS06975	COG0318	PFAM AMP-dependent synthetase and ligase
C7J89_RS06985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7J89_RS06990	COG0494	nUDIX hydrolase
C7J89_RS06995	COG1506	peptidase
C7J89_RS07000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7J89_RS07005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7J89_RS07015	COG0656	L-ascorbic acid biosynthetic process
C7J89_RS07020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7J89_RS07025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7J89_RS07035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7J89_RS07040	COG2207	Transcriptional regulator
C7J89_RS07040	COG1917	Cupin 2, conserved barrel domain protein
C7J89_RS07065	COG3266	domain, Protein
C7J89_RS07065	COG5632	N-Acetylmuramoyl-L-alanine amidase
C7J89_RS07065	COG4193	domain, Protein
C7J89_RS07080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7J89_RS07080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7J89_RS07085	COG0307	riboflavin synthase, alpha
C7J89_RS07090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7J89_RS07090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7J89_RS07095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7J89_RS07105	COG2267	carboxylic ester hydrolase activity
C7J89_RS07110	COG0039	L-malate dehydrogenase activity
C7J89_RS07120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C7J89_RS07125	COG1242	4 iron, 4 sulfur cluster binding
C7J89_RS07130	COG2814	Major facilitator Superfamily
C7J89_RS07135	COG0495	leucyl-tRNA aminoacylation
C7J89_RS07145	COG2081	HI0933 family
C7J89_RS07150	COG2244	polysaccharide biosynthetic process
C7J89_RS07155	COG1187	pseudouridine synthase activity
C7J89_RS07165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7J89_RS07175	COG0510	thiamine kinase activity
C7J89_RS07180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7J89_RS07185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7J89_RS07195	COG1363	Peptidase, m42
C7J89_RS07200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7J89_RS07205	COG4848	Belongs to the UPF0354 family
C7J89_RS07210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7J89_RS07215	COG1674	ftsk spoiiie
C7J89_RS07220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7J89_RS07225	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C7J89_RS07235	COG1605	Chorismate mutase
C7J89_RS07235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7J89_RS07240	COG1609	Transcriptional regulator
C7J89_RS07245	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7J89_RS07250	COG0454	-acetyltransferase
C7J89_RS07255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7J89_RS07260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7J89_RS07270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7J89_RS07275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7J89_RS07280	COG0204	Acyl-transferase
C7J89_RS07285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7J89_RS07285	COG1263	PTS System
C7J89_RS07295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7J89_RS07305	COG1764	response to oxidative stress
C7J89_RS07310	COG0584	glycerophosphoryl diester phosphodiesterase
C7J89_RS07320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7J89_RS07330	COG1956	GAF domain-containing protein
C7J89_RS07335	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7J89_RS07340	COG1104	cysteine desulfurase activity
C7J89_RS07345	COG0301	tRNA thio-modification
C7J89_RS07350	COG0730	response to heat
C7J89_RS07355	COG0616	signal peptide processing
C7J89_RS07360	COG1714	RDD family
C7J89_RS07365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C7J89_RS07370	COG0827	DNA restriction-modification system
C7J89_RS07375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7J89_RS07380	COG0589	response to stress
C7J89_RS07385	COG0686	Belongs to the AlaDH PNT family
C7J89_RS07390	COG3142	Participates in the control of copper homeostasis
C7J89_RS07395	COG0006	proline dipeptidase activity
C7J89_RS07400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7J89_RS07410	COG4109	DRTGG domain
C7J89_RS07415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7J89_RS07425	COG0281	malic enzyme
C7J89_RS07430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7J89_RS07435	COG0825	malonyl-CoA metabolic process
C7J89_RS07440	COG0205	6-phosphofructokinase activity
C7J89_RS07445	COG0469	pyruvate kinase activity
C7J89_RS07450	COG1113	amino acid transport
C7J89_RS07455	COG0372	Belongs to the citrate synthase family
C7J89_RS07460	COG0538	isocitrate dehydrogenase activity
C7J89_RS07465	COG0745	RESPONSE REGULATOR receiver
C7J89_RS07470	COG5002	protein histidine kinase activity
C7J89_RS07475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7J89_RS07475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7J89_RS07485	COG0237	dephospho-CoA kinase activity
C7J89_RS07490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7J89_RS07495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7J89_RS07505	COG1484	DNA-dependent DNA replication
C7J89_RS07510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7J89_RS07515	COG0833	amino acid
C7J89_RS07520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7J89_RS07525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7J89_RS07530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7J89_RS07545	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7J89_RS07550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7J89_RS07555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7J89_RS07560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C7J89_RS07570	COG0181	hydroxymethylbilane synthase activity
C7J89_RS07580	COG0113	porphobilinogen synthase activity
C7J89_RS07585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7J89_RS07595	COG2818	Glycosylase
C7J89_RS07600	COG0525	valine-tRNA ligase activity
C7J89_RS07605	COG0285	dihydrofolate synthase activity
C7J89_RS07615	COG2003	Belongs to the UPF0758 family
C7J89_RS07620	COG0772	Belongs to the SEDS family
C7J89_RS07625	COG1316	TRANSCRIPTIONal
C7J89_RS07665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7J89_RS07670	COG2868	ribosomal protein
C7J89_RS07675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7J89_RS07680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7J89_RS07685	COG4492	Belongs to the UPF0735 family
C7J89_RS07695	COG2255	four-way junction helicase activity
C7J89_RS07700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7J89_RS07705	COG0343	queuine tRNA-ribosyltransferase activity
C7J89_RS07710	COG1862	Preprotein translocase
C7J89_RS07715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7J89_RS07715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7J89_RS07720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7J89_RS07720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7J89_RS07730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7J89_RS07735	COG1490	D-aminoacyl-tRNA deacylase activity
C7J89_RS07740	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7J89_RS07745	COG0124	histidyl-tRNA synthetase
C7J89_RS07750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7J89_RS07760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C7J89_RS07765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7J89_RS07770	COG1959	2 iron, 2 sulfur cluster binding
C7J89_RS07785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7J89_RS07790	COG0488	(ABC) transporter
C7J89_RS07795	COG1104	cysteine desulfurase activity
C7J89_RS07800	COG0482	sulfurtransferase activity
C7J89_RS07810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7J89_RS07815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7J89_RS07820	COG4472	Bacterial protein of unknown function (DUF965)
C7J89_RS07825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7J89_RS07830	COG3906	Belongs to the UPF0473 family
C7J89_RS07835	COG4122	O-methyltransferase activity
C7J89_RS07840	COG0826	peptidase U32
C7J89_RS07845	COG0826	peptidase U32
C7J89_RS07850	COG0572	uridine kinase
C7J89_RS07855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7J89_RS07860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7J89_RS07865	COG1984	allophanate hydrolase subunit 2
C7J89_RS07870	COG0511	ligase activity, forming carbon-carbon bonds
C7J89_RS07875	COG0439	Biotin carboxylase
C7J89_RS07880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C7J89_RS07885	COG1914	H( )-stimulated, divalent metal cation uptake system
C7J89_RS07895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C7J89_RS07900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7J89_RS07905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7J89_RS07910	COG1534	Rna-binding protein
C7J89_RS07915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7J89_RS07920	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7J89_RS07925	COG0799	negative regulation of ribosome biogenesis
C7J89_RS07930	COG2226	methyltransferase
C7J89_RS07935	COG1555	photosystem II stabilization
C7J89_RS07935	COG1596	polysaccharide export
C7J89_RS07940	COG2131	deaminase
C7J89_RS07945	COG2333	competence protein COMEC
C7J89_RS07945	COG0658	competence protein
C7J89_RS07950	COG1466	dna polymerase III delta subunit
C7J89_RS07955	COG0268	Binds directly to 16S ribosomal RNA
C7J89_RS07960	COG0481	GTPase activity
C7J89_RS07965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7J89_RS07970	COG1420	regulation of RNA biosynthetic process
C7J89_RS07975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7J89_RS07980	COG0443	Heat shock 70 kDa protein
C7J89_RS07985	COG0484	heat shock protein binding
C7J89_RS07990	COG2264	protein methyltransferase activity
C7J89_RS07995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7J89_RS08000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7J89_RS08010	COG1030	water channel activity
C7J89_RS08015	COG4864	UPF0365 protein
C7J89_RS08025	COG1702	phosphate starvation-inducible protein PhoH
C7J89_RS08030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7J89_RS08040	COG0295	cytidine deaminase activity
C7J89_RS08045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7J89_RS08050	COG1381	Involved in DNA repair and RecF pathway recombination
C7J89_RS08055	COG0423	glycine-tRNA ligase activity
C7J89_RS08060	COG0517	IMP dehydrogenase activity
C7J89_RS08065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7J89_RS08070	COG0358	DNA primase activity
C7J89_RS08075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7J89_RS08080	COG2384	SAM-dependent methyltransferase
C7J89_RS08090	COG0513	Belongs to the DEAD box helicase family
C7J89_RS08095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7J89_RS08100	COG1121	(ABC) transporter
C7J89_RS08105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7J89_RS08115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7J89_RS08120	COG0768	penicillin binding
C7J89_RS08125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7J89_RS08130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7J89_RS08140	COG4483	Protein conserved in bacteria
C7J89_RS08145	COG1940	carbohydrate kinase activity
C7J89_RS08150	COG0011	TIGRFAM Protein of
C7J89_RS08155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7J89_RS08160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7J89_RS08195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7J89_RS08200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7J89_RS08205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7J89_RS08210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7J89_RS08215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7J89_RS08220	COG0095	Lipoate-protein ligase
C7J89_RS08235	COG0006	proline dipeptidase activity
C7J89_RS08240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7J89_RS08245	COG0511	ligase activity, forming carbon-carbon bonds
C7J89_RS08250	COG0439	Biotin carboxylase
C7J89_RS08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7J89_RS08265	COG1570	exodeoxyribonuclease VII activity
C7J89_RS08280	COG1438	arginine binding
C7J89_RS08285	COG0497	DNA recombination
C7J89_RS08290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7J89_RS08295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7J89_RS08300	COG0022	dehydrogenase e1 component
C7J89_RS08305	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7J89_RS08315	COG4129	membrane
C7J89_RS08320	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7J89_RS08330	COG0366	Alpha amylase catalytic
C7J89_RS08345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7J89_RS08350	COG1234	tRNA 3'-trailer cleavage
C7J89_RS08355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7J89_RS08365	COG0667	Aldo Keto reductase
C7J89_RS08370	COG0494	nUDIX hydrolase
C7J89_RS08375	COG0735	belongs to the Fur family
C7J89_RS08380	COG4974	Belongs to the 'phage' integrase family
C7J89_RS08390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7J89_RS08395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7J89_RS08400	COG1187	pseudouridine synthase activity
C7J89_RS08405	COG0745	RESPONSE REGULATOR receiver
C7J89_RS08420	COG1141	Ferredoxin
C7J89_RS08430	COG0514	ATP-dependent DNA helicase (RecQ)
C7J89_RS08435	COG1388	LysM domain
C7J89_RS08435	COG1388	LysM domain
C7J89_RS08440	COG0492	ferredoxin-NADP+ reductase activity
C7J89_RS08445	COG0252	asparaginase activity
C7J89_RS08450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7J89_RS08455	COG0539	negative regulation of cytoplasmic translation
C7J89_RS08460	COG1160	GTP binding
C7J89_RS08465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7J89_RS08480	COG2226	methyltransferase
C7J89_RS08485	COG0142	geranyltranstransferase activity
C7J89_RS08490	COG0105	UTP biosynthetic process
C7J89_RS08495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7J89_RS08500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7J89_RS08505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7J89_RS08515	COG5582	Belongs to the UPF0302 family
C7J89_RS08520	COG4347	Protein of unknown function (DUF1405)
C7J89_RS08525	COG2738	Putative neutral zinc metallopeptidase
C7J89_RS08530	COG1694	Mazg nucleotide pyrophosphohydrolase
C7J89_RS08535	COG0438	transferase activity, transferring glycosyl groups
C7J89_RS08540	COG0617	tRNA 3'-terminal CCA addition
C7J89_RS08545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7J89_RS08545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7J89_RS08550	COG1199	ATP-dependent helicase activity
C7J89_RS08550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7J89_RS08555	COG0017	Asparaginyl-tRNA synthetase
C7J89_RS08560	COG3935	DnaD domain protein
C7J89_RS08565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7J89_RS08575	COG4499	WXG100 protein secretion system (Wss), protein YukC
C7J89_RS08575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7J89_RS08580	COG3331	DNA recombination
C7J89_RS08590	COG4474	Belongs to the UPF0398 family
C7J89_RS08605	COG0116	Belongs to the methyltransferase superfamily
C7J89_RS08610	COG2962	Rard protein
C7J89_RS08620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C7J89_RS08625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7J89_RS08640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C7J89_RS08650	COG1413	lyase activity
C7J89_RS08680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7J89_RS08695	COG0793	Belongs to the peptidase S41A family
C7J89_RS08705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7J89_RS08710	COG0671	phosphoesterase, PA-phosphatase related
C7J89_RS08715	COG0745	RESPONSE REGULATOR receiver
C7J89_RS08720	COG5002	protein histidine kinase activity
C7J89_RS08725	COG0567	Dehydrogenase, E1 component
C7J89_RS08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7J89_RS08745	COG0640	Transcriptional regulator
C7J89_RS08775	COG1131	(ABC) transporter
C7J89_RS08800	COG0714	Associated with various cellular activities
C7J89_RS08805	COG4548	von Willebrand factor, type A
C7J89_RS08810	COG1114	Component of the transport system for branched-chain amino acids
C7J89_RS08815	COG3853	Toxic anion resistance protein (TelA)
C7J89_RS08825	COG1254	Belongs to the acylphosphatase family
C7J89_RS08835	COG1278	Cold shock
C7J89_RS08850	COG1473	amidohydrolase
C7J89_RS08855	COG2171	N-acyltransferase activity
C7J89_RS08860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7J89_RS08865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7J89_RS08870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7J89_RS08875	COG0527	aspartate kinase activity
C7J89_RS08885	COG0488	(ABC) transporter
C7J89_RS08890	COG2996	Protein conserved in bacteria
C7J89_RS08895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7J89_RS08900	COG0573	inorganic phosphate transmembrane transporter activity
C7J89_RS08905	COG0581	inorganic phosphate transmembrane transporter activity
C7J89_RS08910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7J89_RS08915	COG0704	Plays a role in the regulation of phosphate uptake
C7J89_RS08920	COG1164	Oligoendopeptidase f
C7J89_RS08930	COG4607	ABC-type enterochelin transport system periplasmic component
C7J89_RS08940	COG2348	transferase activity, transferring amino-acyl groups
C7J89_RS08950	COG0159	tryptophan synthase activity
C7J89_RS08965	COG0134	indole-3-glycerol-phosphate synthase activity
C7J89_RS08970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7J89_RS08975	COG0512	Glutamine amidotransferase of anthranilate synthase
C7J89_RS08980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7J89_RS08985	COG1363	Peptidase, m42
C7J89_RS08990	COG0287	Prephenate dehydrogenase
C7J89_RS08995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7J89_RS09000	COG2169	Transcriptional regulator
C7J89_RS09005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7J89_RS09010	COG1942	4-Oxalocrotonate Tautomerase
C7J89_RS09025	COG0392	lysyltransferase activity
C7J89_RS09025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7J89_RS09035	COG0628	permease
C7J89_RS09040	COG3711	transcriptional antiterminator
C7J89_RS09045	COG1115	amino acid carrier protein
C7J89_RS09050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7J89_RS09060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7J89_RS09065	COG4841	protein insertion into membrane
C7J89_RS09075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C7J89_RS09080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C7J89_RS09085	COG1970	mechanosensitive ion channel activity
C7J89_RS09090	COG0419	ATPase involved in DNA repair
C7J89_RS09095	COG0420	3'-5' exonuclease activity
C7J89_RS09100	COG4846	Membrane protein involved in cytochrome C biogenesis
C7J89_RS09130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7J89_RS09135	COG2340	Cysteine-rich secretory protein family
C7J89_RS09140	COG0516	GMP reductase activity
C7J89_RS09145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7J89_RS09150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7J89_RS09155	COG0753	catalase activity
C7J89_RS09160	COG0833	amino acid
C7J89_RS09170	COG0561	phosphatase activity
C7J89_RS09175	COG0083	homoserine kinase activity
C7J89_RS09180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7J89_RS09185	COG0460	homoserine dehydrogenase
C7J89_RS09190	COG0527	aspartate kinase activity
C7J89_RS09210	COG1525	nuclease
C7J89_RS09220	COG2197	response regulator
C7J89_RS09230	COG0842	Transport permease protein
C7J89_RS09235	COG1131	(ABC) transporter
C7J89_RS09250	COG0789	Transcriptional regulator
C7J89_RS09255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C7J89_RS09260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7J89_RS09265	COG0386	Belongs to the glutathione peroxidase family
C7J89_RS09270	COG1923	regulation of RNA biosynthetic process
C7J89_RS09275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7J89_RS09285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7J89_RS09290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7J89_RS09295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7J89_RS09300	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C7J89_RS09305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7J89_RS09310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7J89_RS09320	COG4550	Control of competence regulator ComK, YlbF/YmcA
C7J89_RS09325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7J89_RS09340	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7J89_RS09345	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7J89_RS09345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7J89_RS09350	COG1692	metallophosphoesterase
C7J89_RS09360	COG1418	mRNA catabolic process
C7J89_RS09365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7J89_RS09370	COG1058	Belongs to the CinA family
C7J89_RS09370	COG1546	Belongs to the CinA family
C7J89_RS09390	COG0300	oxidoreductase activity
C7J89_RS09395	COG0612	Peptidase, M16
C7J89_RS09400	COG0612	Peptidase, M16
C7J89_RS09405	COG2188	Transcriptional regulator
C7J89_RS09410	COG1674	ftsk spoiiie
C7J89_RS09415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C7J89_RS09425	COG1185	polyribonucleotide nucleotidyltransferase activity
C7J89_RS09430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7J89_RS09435	COG0196	riboflavin kinase activity
C7J89_RS09440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7J89_RS09445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7J89_RS09460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7J89_RS09465	COG1358	cellular component organization or biogenesis
C7J89_RS09470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7J89_RS09475	COG0195	Participates in both transcription termination and antitermination
C7J89_RS09480	COG0779	Required for maturation of 30S ribosomal subunits
C7J89_RS09485	COG2176	DNA-directed DNA polymerase activity
C7J89_RS09490	COG0442	prolyl-tRNA aminoacylation
C7J89_RS09500	COG4589	Belongs to the CDS family
C7J89_RS09505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7J89_RS09510	COG0233	cytoplasmic translational termination
C7J89_RS09515	COG0528	UMP kinase activity
C7J89_RS09520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7J89_RS09525	COG0052	Belongs to the universal ribosomal protein uS2 family
C7J89_RS09530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C7J89_RS09535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7J89_RS09540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7J89_RS09545	COG4974	Belongs to the 'phage' integrase family
C7J89_RS09550	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C7J89_RS09555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7J89_RS09560	COG0758	DNA mediated transformation
C7J89_RS09565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7J89_RS09570	COG0045	succinate-CoA ligase (ADP-forming) activity
C7J89_RS09575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7J89_RS09585	COG4485	Bacterial membrane protein, YfhO
C7J89_RS09595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C7J89_RS09615	COG0336	Belongs to the RNA methyltransferase TrmD family
C7J89_RS09620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7J89_RS09625	COG0228	four-way junction DNA binding
C7J89_RS09635	COG1522	sequence-specific DNA binding
C7J89_RS09640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7J89_RS09645	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C7J89_RS09650	COG0552	protein localization to endoplasmic reticulum
C7J89_RS09655	COG1196	nuclear chromosome segregation
C7J89_RS09660	COG0571	ribonuclease III activity
C7J89_RS09665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7J89_RS09680	COG0416	fatty acid biosynthetic process
C7J89_RS09685	COG1349	DNA-binding transcription factor activity
C7J89_RS09700	COG1760	l-serine dehydratase
C7J89_RS09705	COG1760	l-serine dehydratase
C7J89_RS09710	COG1461	Dihydroxyacetone kinase
C7J89_RS09715	COG1302	Protein conserved in bacteria
C7J89_RS09720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7J89_RS09725	COG1564	THIamine pyrophosphokinase
C7J89_RS09730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7J89_RS09735	COG1162	GTPase activity
C7J89_RS09745	COG0631	protein serine/threonine phosphatase activity
C7J89_RS09750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7J89_RS09755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7J89_RS09755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7J89_RS09760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7J89_RS09785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7J89_RS09790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7J89_RS09795	COG1758	RNA polymerase activity
C7J89_RS09800	COG0194	GDP metabolic process
C7J89_RS09805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C7J89_RS09815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7J89_RS09825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7J89_RS09830	COG0284	orotidine-5'-phosphate decarboxylase activity
C7J89_RS09835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7J89_RS09840	COG0505	Belongs to the CarA family
C7J89_RS09850	COG0540	Belongs to the ATCase OTCase family
C7J89_RS09860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7J89_RS09865	COG0564	pseudouridine synthase activity
C7J89_RS09875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7J89_RS09880	COG3599	regulation of cell shape
C7J89_RS09890	COG0762	integral membrane protein
C7J89_RS09895	COG1799	cell septum assembly
C7J89_RS09900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7J89_RS09905	COG1496	oxidoreductase activity
C7J89_RS09910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C7J89_RS09915	COG0849	cell division
C7J89_RS09925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7J89_RS09930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7J89_RS09935	COG0768	penicillin binding
C7J89_RS09940	COG4839	cell division protein FtsL
C7J89_RS09945	COG0275	rRNA processing
C7J89_RS09950	COG2001	Belongs to the MraZ family
C7J89_RS09955	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C7J89_RS09960	COG0454	-acetyltransferase
C7J89_RS09965	COG1011	Hydrolase
C7J89_RS10025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C7J89_RS10030	COG1053	succinate dehydrogenase
C7J89_RS10035	COG2009	succinate dehydrogenase
C7J89_RS10040	COG0322	excinuclease ABC activity
C7J89_RS10045	COG3118	belongs to the thioredoxin family
C7J89_RS10050	COG1193	negative regulation of DNA recombination
C7J89_RS10055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7J89_RS10055	COG1796	DNA polymerase
C7J89_RS10065	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C7J89_RS10070	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7J89_RS10075	COG0072	phenylalanine-tRNA ligase activity
C7J89_RS10080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7J89_RS10085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7J89_RS10090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7J89_RS10100	COG1323	Belongs to the UPF0348 family
C7J89_RS10105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7J89_RS10110	COG0742	ribosomal rna small subunit methyltransferase
C7J89_RS10120	COG4471	UPF0298 protein
C7J89_RS10125	COG0584	glycerophosphoryl diester phosphodiesterase
C7J89_RS10130	COG3679	Belongs to the UPF0342 family
C7J89_RS10140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7J89_RS10150	COG0109	protoheme IX farnesyltransferase activity
C7J89_RS10155	COG1612	heme a metabolic process
C7J89_RS10165	COG0772	Belongs to the SEDS family
C7J89_RS10170	COG4838	Belongs to the UPF0358 family
C7J89_RS10175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C7J89_RS10180	COG4896	Protein conserved in bacteria
C7J89_RS10185	COG1217	gtp-binding protein TYPA
C7J89_RS10195	COG0483	inositol monophosphate 1-phosphatase activity
C7J89_RS10200	COG4493	Belongs to the UPF0637 family
C7J89_RS10210	COG1914	H( )-stimulated, divalent metal cation uptake system
C7J89_RS10220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C7J89_RS10225	COG1177	transmembrane transport
C7J89_RS10230	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7J89_RS10235	COG3842	ATPase activity
C7J89_RS10245	COG4476	Belongs to the UPF0223 family
C7J89_RS10275	COG0242	peptide deformylase activity
C7J89_RS10285	COG5503	Protein of unknown function (DUF1447)
C7J89_RS10290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C7J89_RS10295	COG0569	domain protein
C7J89_RS10300	COG1294	oxidase, subunit
C7J89_RS10305	COG1271	oxidase subunit
C7J89_RS10315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7J89_RS10320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7J89_RS10330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7J89_RS10345	COG4172	Belongs to the ABC transporter superfamily
C7J89_RS10350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C7J89_RS10360	COG0138	bifunctional purine biosynthesis protein purh
C7J89_RS10370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7J89_RS10380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7J89_RS10385	COG0047	phosphoribosylformylglycinamidine synthase activity
C7J89_RS10390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7J89_RS10395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7J89_RS10400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7J89_RS10405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7J89_RS10410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7J89_RS10420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7J89_RS10430	COG1845	cytochrome c oxidase, subunit III
C7J89_RS10435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C7J89_RS10445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7J89_RS10450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7J89_RS10455	COG1316	TRANSCRIPTIONal
C7J89_RS10480	COG3594	Acyltransferase
C7J89_RS10485	COG0436	Aminotransferase
C7J89_RS10495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7J89_RS10505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C7J89_RS10510	COG1169	isochorismate synthase
C7J89_RS10515	COG1575	Belongs to the MenA family. Type 1 subfamily
C7J89_RS10535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7J89_RS10550	COG5632	N-Acetylmuramoyl-L-alanine amidase
C7J89_RS10550	COG1388	LysM domain
C7J89_RS10605	COG0739	heme binding
C7J89_RS10700	COG0756	dUTP diphosphatase activity
C7J89_RS10765	COG0305	Participates in initiation and elongation during chromosome replication
C7J89_RS10785	COG0629	single-stranded DNA binding
C7J89_RS10820	COG3620	sequence-specific DNA binding
C7J89_RS10865	COG4903	ComK protein
C7J89_RS10880	COG4873	Protein conserved in bacteria
C7J89_RS10890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7J89_RS10900	COG0737	Belongs to the 5'-nucleotidase family
C7J89_RS10905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7J89_RS10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7J89_RS10915	COG0861	Integral membrane protein TerC family
C7J89_RS10920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7J89_RS10930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7J89_RS10935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7J89_RS10940	COG2814	Major facilitator Superfamily
C7J89_RS10945	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C7J89_RS10950	COG2382	esterase
C7J89_RS10955	COG1115	amino acid carrier protein
C7J89_RS10960	COG0628	permease
C7J89_RS10970	COG0475	glutathione-regulated potassium exporter activity
C7J89_RS10970	COG0569	domain protein
C7J89_RS10975	COG2239	Acts as a magnesium transporter
C7J89_RS10980	COG0564	pseudouridine synthase activity
C7J89_RS10985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7J89_RS10990	COG2357	RelA SpoT domain protein
C7J89_RS11000	COG4116	CYTH
C7J89_RS11005	COG2346	COG2346, Truncated hemoglobins
C7J89_RS11010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C7J89_RS11015	COG1164	Oligoendopeptidase f
C7J89_RS11030	COG1393	Belongs to the ArsC family
C7J89_RS11035	COG0180	Tryptophanyl-tRNA synthetase
C7J89_RS11040	COG4166	transmembrane transport
C7J89_RS11045	COG4608	Belongs to the ABC transporter superfamily
C7J89_RS11050	COG0444	Belongs to the ABC transporter superfamily
C7J89_RS11055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7J89_RS11060	COG0601	transmembrane transport
C7J89_RS11080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7J89_RS11105	COG0561	phosphatase activity
C7J89_RS11110	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7J89_RS11120	COG0179	Fumarylacetoacetate (FAA) hydrolase
C7J89_RS11125	COG1074	ATP-dependent DNA helicase activity
C7J89_RS11130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7J89_RS11145	COG0398	Pfam SNARE associated Golgi protein
C7J89_RS11150	COG0166	Belongs to the GPI family
C7J89_RS11155	COG0137	argininosuccinate synthase activity
C7J89_RS11160	COG0165	Argininosuccinate lyase
C7J89_RS11170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7J89_RS11175	COG1902	pentaerythritol trinitrate reductase activity
C7J89_RS11180	COG1098	S1 RNA binding domain
C7J89_RS11185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7J89_RS11195	COG2111	Na H antiporter
C7J89_RS11195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7J89_RS11200	COG2111	Na H antiporter
C7J89_RS11205	COG1006	Multisubunit Na H antiporter MnhC subunit
C7J89_RS11210	COG0651	ATP synthesis coupled electron transport
C7J89_RS11215	COG1863	multisubunit Na H antiporter MnhE subunit
C7J89_RS11220	COG2212	antiporter activity
C7J89_RS11225	COG1320	monovalent cation:proton antiporter activity
C7J89_RS11235	COG2050	protein possibly involved in aromatic compounds catabolism
C7J89_RS11240	COG2056	Na+-H+ antiporter family
C7J89_RS11245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7J89_RS11250	COG1252	NADH dehydrogenase
C7J89_RS11255	COG0316	Belongs to the HesB IscA family
C7J89_RS11260	COG4844	belongs to the
C7J89_RS11265	COG1252	NADH dehydrogenase
C7J89_RS11270	COG4837	Protein of unknown function (DUF1462)
C7J89_RS11275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7J89_RS11280	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C7J89_RS11285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7J89_RS11290	COG1696	Membrane protein involved in D-alanine export
C7J89_RS11295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7J89_RS11305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7J89_RS11310	COG0647	UMP catabolic process
C7J89_RS11315	COG2445	Protein of unknown function DUF86
C7J89_RS11325	COG4470	Protein conserved in bacteria
C7J89_RS11335	COG0737	Belongs to the 5'-nucleotidase family
C7J89_RS11340	COG1801	Protein of unknown function DUF72
C7J89_RS11345	COG2070	2-Nitropropane dioxygenase
C7J89_RS11350	COG1253	flavin adenine dinucleotide binding
C7J89_RS11355	COG0719	Fe-S assembly protein
C7J89_RS11360	COG0822	iron-sulfur transferase activity
C7J89_RS11365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7J89_RS11370	COG0719	Fe-S assembly protein
C7J89_RS11375	COG0396	ATPase activity
C7J89_RS11380	COG1464	Belongs to the NlpA lipoprotein family
C7J89_RS11385	COG2011	ABC-type metal ion transport system permease component
C7J89_RS11390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7J89_RS11400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7J89_RS11405	COG0509	glycine decarboxylation via glycine cleavage system
C7J89_RS11410	COG1393	Belongs to the ArsC family
C7J89_RS11415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7J89_RS11425	COG0710	3-dehydroquinate dehydratase activity
C7J89_RS11430	COG1764	response to oxidative stress
C7J89_RS11445	COG2851	Citrate transporter
C7J89_RS11465	COG2314	TM2 domain
C7J89_RS11530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7J89_RS11565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7J89_RS11570	COG0557	exoribonuclease II activity
C7J89_RS11575	COG1647	Serine aminopeptidase, S33
C7J89_RS11580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7J89_RS11590	COG0148	phosphopyruvate hydratase activity
C7J89_RS11595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C7J89_RS11600	COG0149	triose-phosphate isomerase activity
C7J89_RS11605	COG0126	phosphoglycerate kinase activity
C7J89_RS11635	COG1090	epimerase
C7J89_RS11640	COG0740	serine-type endopeptidase activity
C7J89_RS11650	COG1136	(ABC) transporter
C7J89_RS11650	COG0577	efflux transmembrane transporter activity
C7J89_RS11665	COG1481	regulation of sporulation
C7J89_RS11670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7J89_RS11675	COG1660	Displays ATPase and GTPase activities
C7J89_RS11680	COG0492	ferredoxin-NADP+ reductase activity
C7J89_RS11690	COG0110	maltose O-acetyltransferase activity
C7J89_RS11695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7J89_RS11700	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7J89_RS11705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7J89_RS11710	COG0556	nucleotide-excision repair
C7J89_RS11725	COG3942	CHAP domain
C7J89_RS11725	COG1388	LysM domain
C7J89_RS11735	COG0653	protein targeting
C7J89_RS11740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7J89_RS11745	COG1040	competence protein
C7J89_RS11750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7J89_RS11760	COG1739	Uncharacterized protein family UPF0029
C7J89_RS11765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7J89_RS11770	COG2199	diguanylate cyclase activity
C7J89_RS11785	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7J89_RS11795	COG1929	Belongs to the glycerate kinase type-1 family
C7J89_RS11815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7J89_RS11825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7J89_RS11830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7J89_RS11835	COG1780	Probably involved in ribonucleotide reductase function
C7J89_RS11845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7J89_RS11850	COG3104	oligopeptide transport
C7J89_RS11855	COG3104	oligopeptide transport
C7J89_RS11860	COG1597	lipid kinase activity
C7J89_RS11870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7J89_RS11875	COG1174	glycine betaine transport
C7J89_RS11880	COG1125	glycine betaine transport
C7J89_RS11880	COG0517	IMP dehydrogenase activity
C7J89_RS11885	COG0514	ATP-dependent DNA helicase (RecQ)
C7J89_RS11890	COG0488	(ABC) transporter
C7J89_RS11895	COG1368	sulfuric ester hydrolase activity
C7J89_RS11905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7J89_RS11920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7J89_RS11930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C7J89_RS11935	COG0720	synthase
C7J89_RS11940	COG0602	queuosine metabolic process
C7J89_RS11960	COG0463	Glycosyl transferase, family 2
C7J89_RS11965	COG0656	L-ascorbic acid biosynthetic process
C7J89_RS11970	COG1253	flavin adenine dinucleotide binding
C7J89_RS11975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7J89_RS11975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7J89_RS11975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7J89_RS11980	COG1105	Belongs to the carbohydrate kinase PfkB family
C7J89_RS11985	COG1349	DNA-binding transcription factor activity
C7J89_RS11990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7J89_RS11995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7J89_RS12025	COG0586	Pfam SNARE associated Golgi protein
C7J89_RS12035	COG4989	oxidoreductase activity
C7J89_RS12040	COG0523	cobalamin synthesis protein
C7J89_RS12050	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7J89_RS12055	COG4988	ABC transporter
C7J89_RS12060	COG1968	undecaprenyl-diphosphatase activity
C7J89_RS12070	COG1671	Belongs to the UPF0178 family
C7J89_RS12105	COG2814	Major facilitator Superfamily
C7J89_RS12110	COG2839	Protein conserved in bacteria
C7J89_RS12115	COG2814	Major facilitator Superfamily
C7J89_RS12120	COG0583	DNA-binding transcription factor activity
C7J89_RS12130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7J89_RS12140	COG0217	transcriptional regulatory protein
C7J89_RS12150	COG3942	CHAP domain
C7J89_RS12150	COG1388	LysM domain
C7J89_RS12155	COG0306	phosphate transporter
C7J89_RS12160	COG1392	Phosphate transport regulator
C7J89_RS12165	COG2205	protein histidine kinase activity
C7J89_RS12170	COG0745	RESPONSE REGULATOR receiver
C7J89_RS12175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7J89_RS12200	COG1461	Dihydroxyacetone kinase
C7J89_RS12205	COG2376	Dihydroxyacetone kinase
C7J89_RS12210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS12215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS12220	COG1120	ATPase activity
C7J89_RS12225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7J89_RS12230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7J89_RS12235	COG1132	(ABC) transporter
C7J89_RS12240	COG1686	Belongs to the peptidase S11 family
C7J89_RS12245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7J89_RS12255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7J89_RS12260	COG1682	transport, permease protein
C7J89_RS12265	COG1134	teichoic acid transport
C7J89_RS12275	COG1682	transport, permease protein
C7J89_RS12280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C7J89_RS12300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7J89_RS12315	COG1320	monovalent cation:proton antiporter activity
C7J89_RS12320	COG2212	antiporter activity
C7J89_RS12325	COG1863	multisubunit Na H antiporter MnhE subunit
C7J89_RS12330	COG0651	ATP synthesis coupled electron transport
C7J89_RS12335	COG1006	Multisubunit Na H antiporter MnhC subunit
C7J89_RS12340	COG2111	Na H antiporter
C7J89_RS12345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7J89_RS12345	COG2111	Na H antiporter
C7J89_RS12350	COG4974	Belongs to the 'phage' integrase family
C7J89_RS12380	COG2267	carboxylic ester hydrolase activity
C7J89_RS12400	COG0546	phosphoglycolate phosphatase activity
C7J89_RS12405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7J89_RS12410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7J89_RS12415	COG0789	Transcriptional regulator
C7J89_RS12415	COG4978	Transcriptional regulator
C7J89_RS12425	COG0018	arginyl-trna synthetase
C7J89_RS12440	COG1078	dGTPase activity
C7J89_RS12450	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7J89_RS12455	COG0667	Aldo Keto reductase
C7J89_RS12460	COG4844	belongs to the
C7J89_RS12470	COG0673	inositol 2-dehydrogenase activity
C7J89_RS12480	COG0673	inositol 2-dehydrogenase activity
C7J89_RS12485	COG1737	Transcriptional regulator
C7J89_RS12505	COG0095	Lipoate-protein ligase
C7J89_RS12510	COG0280	phosphate acetyltransferase
C7J89_RS12515	COG3253	May function as heme-dependent peroxidase
C7J89_RS12530	COG0477	Major facilitator Superfamily
C7J89_RS12545	COG2363	Small membrane protein
C7J89_RS12570	COG0039	L-malate dehydrogenase activity
C7J89_RS12575	COG2211	Major facilitator Superfamily
C7J89_RS12595	COG0183	Belongs to the thiolase family
C7J89_RS12600	COG0318	PFAM AMP-dependent synthetase and ligase
C7J89_RS12610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C7J89_RS12615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7J89_RS12620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7J89_RS12625	COG1469	GTP cyclohydrolase I activity
C7J89_RS12640	COG0431	NADPH-dependent FMN reductase
C7J89_RS12645	COG0561	phosphatase activity
C7J89_RS12655	COG1428	Deoxynucleoside kinase
C7J89_RS12660	COG1428	Deoxynucleoside kinase
C7J89_RS12675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7J89_RS12680	COG1942	4-Oxalocrotonate Tautomerase
C7J89_RS12685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7J89_RS12690	COG0667	Aldo Keto reductase
C7J89_RS12695	COG2814	Major facilitator Superfamily
C7J89_RS12710	COG2814	Major facilitator Superfamily
C7J89_RS12720	COG1113	amino acid transport
C7J89_RS12725	COG0010	Belongs to the arginase family
C7J89_RS12730	COG1914	H( )-stimulated, divalent metal cation uptake system
C7J89_RS12780	COG0302	gtp cyclohydrolase
C7J89_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS12795	COG1069	ribulokinase activity
C7J89_RS12800	COG2814	Major facilitator Superfamily
C7J89_RS12805	COG1349	DNA-binding transcription factor activity
C7J89_RS12810	COG0656	L-ascorbic acid biosynthetic process
C7J89_RS12815	COG2814	Major facilitator Superfamily
C7J89_RS12820	COG1733	regulation of RNA biosynthetic process
C7J89_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
C7J89_RS12830	COG1312	Catalyzes the dehydration of D-mannonate
C7J89_RS12835	COG1904	glucuronate isomerase
C7J89_RS12845	COG0800	Aldolase
C7J89_RS12850	COG1609	Transcriptional regulator
C7J89_RS12865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7J89_RS12880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C7J89_RS12885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C7J89_RS12915	COG1473	amidohydrolase
C7J89_RS12920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7J89_RS12925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7J89_RS12930	COG0049	tRNA binding
C7J89_RS12945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7J89_RS12950	COG0085	RNA polymerase activity
C7J89_RS12955	COG2813	Specifically methylates the guanine in position
C7J89_RS12965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7J89_RS12975	COG0081	regulation of translation
C7J89_RS12980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7J89_RS12985	COG0250	Participates in transcription elongation, termination and antitermination
C7J89_RS13010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7J89_RS13015	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7J89_RS13020	COG0215	cysteine-tRNA ligase activity
C7J89_RS13025	COG1045	serine acetyltransferase
C7J89_RS13030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7J89_RS13035	COG4956	integral membrane protein (PIN domain superfamily)
C7J89_RS13040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C7J89_RS13045	COG0542	response to heat
C7J89_RS13050	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C7J89_RS13055	COG3880	PFAM UvrB UvrC protein
C7J89_RS13060	COG4463	regulation of RNA biosynthetic process
C7J89_RS13065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7J89_RS13070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C7J89_RS13075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C7J89_RS13080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7J89_RS13130	COG0275	rRNA processing