locus-tag	class	description
E5Z44_RS00005	ENOG4105D1F	ATP-binding protein
E5Z44_RS00025	ENOG4108UT2	hemolysin iii
E5Z44_RS00030	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
E5Z44_RS00035	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
E5Z44_RS00040	ENOG4107DUR	UPF0457 protein
E5Z44_RS00045	ENOG4105DWD	nucleoside recognition domain protein
E5Z44_RS00050	ENOG4108U1V	ABC transporter, permease
E5Z44_RS00055	ENOG4105DQ5	transport system permease protein
E5Z44_RS00060	ENOG4108HUF	Transporter
E5Z44_RS00090	ENOG4105CIS	alcohol dehydrogenase
E5Z44_RS00095	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
E5Z44_RS00105	ENOG4105CS2	ec 3.2.1.21
E5Z44_RS00110	ENOG4105CK1	PTS System
E5Z44_RS00115	ENOG4105VCP	PTS System
E5Z44_RS00120	ENOG4105D2M	Aldolase
E5Z44_RS00125	ENOG4105DE4	1-phosphofructokinase
E5Z44_RS00130	ENOG4108YZG	isomerase
E5Z44_RS00140	ENOG4105E98	transcriptional regulator DeoR family
E5Z44_RS00145	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E5Z44_RS00185	ENOG4105PF9	Transcriptional regulator
E5Z44_RS00205	ENOG4105DA5	(ABC) transporter
E5Z44_RS00225	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E5Z44_RS00230	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E5Z44_RS00240	ENOG4108JJB	ABC transporter
E5Z44_RS00250	ENOG4108ZT0	50S ribosomal protein l17
E5Z44_RS00255	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E5Z44_RS00265	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5Z44_RS00270	ENOG41067V7	50S ribosomal protein L36
E5Z44_RS00275	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E5Z44_RS00280	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E5Z44_RS00285	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E5Z44_RS00295	ENOG4105VPB	50S ribosomal protein L30
E5Z44_RS00300	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E5Z44_RS00305	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E5Z44_RS00310	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E5Z44_RS00315	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E5Z44_RS00330	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E5Z44_RS00340	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E5Z44_RS00350	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E5Z44_RS00355	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E5Z44_RS00365	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E5Z44_RS00370	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5Z44_RS00375	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E5Z44_RS00380	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E5Z44_RS00385	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E5Z44_RS00400	ENOG4105C7N	Xanthine uracil vitamin C permease
E5Z44_RS00430	ENOG4108TV1	Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity)
E5Z44_RS00455	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E5Z44_RS00460	ENOG41082CS	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
E5Z44_RS00470	ENOG4108ZAF	Molybdopterin
E5Z44_RS00490	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
E5Z44_RS00495	ENOG4105D06	uba thif-type nad fad binding protein
E5Z44_RS00500	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS00505	ENOG4105E0C	molybdate abc transporter
E5Z44_RS00510	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
E5Z44_RS00515	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
E5Z44_RS00525	ENOG4107ZYJ	bioY protein
E5Z44_RS00540	ENOG4105FDT	acyl-CoA dehydrogenase
E5Z44_RS00575	ENOG4105DFD	Na H antiporter
E5Z44_RS00600	ENOG41080TC	multidrug resistance protein
E5Z44_RS00605	ENOG4105C5I	Dehydrogenase
E5Z44_RS00610	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
E5Z44_RS00630	ENOG4108KGH	TRANSCRIPTIONal
E5Z44_RS00640	ENOG4105E98	transcriptional regulator DeoR family
E5Z44_RS00650	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5Z44_RS00655	ENOG4105C5Y	PTS System
E5Z44_RS00660	ENOG4106KNT	transcriptional regulator
E5Z44_RS00685	ENOG4107YBY	Hydrolase
E5Z44_RS00695	ENOG4105CI1	PTS System
E5Z44_RS00700	ENOG4108Q3X	Transcriptional regulator
E5Z44_RS00720	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
E5Z44_RS00735	ENOG4106E7R	Lysostaphin resistance protein A
E5Z44_RS00740	ENOG4105E66	phosphoriboisomerase A
E5Z44_RS00745	ENOG4108RPX	mosc domain containing protein
E5Z44_RS00750	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E5Z44_RS00760	ENOG4108VX5	3-methyladenine DNA glycosylase
E5Z44_RS00765	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
E5Z44_RS00770	ENOG4105D7N	magnesium and cobalt transport protein CorA
E5Z44_RS00795	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E5Z44_RS00800	ENOG4105CW7	secretion protein, HlyD family
E5Z44_RS00810	ENOG4105C2C	drug resistance transporter, Bcr CflA
E5Z44_RS00820	ENOG41062A4	Transcriptional regulator
E5Z44_RS00860	ENOG4105DWT	malate dehydrogenase (quinone)
E5Z44_RS00865	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
E5Z44_RS00875	ENOG4107RZX	Teichoic acid biosynthesis protein
E5Z44_RS00885	ENOG41090PH	Protease synthase and sporulation negative regulatory protein pai 1
E5Z44_RS00890	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E5Z44_RS00895	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E5Z44_RS00900	ENOG4107SJW	iron permease, FTR1
E5Z44_RS00905	ENOG4105DBE	peroxidase
E5Z44_RS00910	ENOG410650H	(LipO)protein
E5Z44_RS00930	ENOG4105CAY	ferredoxin--nadp reductase
E5Z44_RS00935	ENOG4105YB8	TM2 domain containing protein
E5Z44_RS00975	ENOG4105F04	LysR family Transcriptional regulator
E5Z44_RS00980	ENOG4105F27	Major Facilitator
E5Z44_RS01025	ENOG4105FR1	rard protein
E5Z44_RS01030	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
E5Z44_RS01050	ENOG4108YZ9	Urea amidohydrolase subunit gamma
E5Z44_RS01060	ENOG4105CQM	Urea amidohydrolase subunit alpha
E5Z44_RS01065	ENOG4105HFU	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
E5Z44_RS01080	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
E5Z44_RS01085	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
E5Z44_RS01100	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS01105	ENOG4105EFJ	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS01115	ENOG4105C3S	Mate efflux family protein
E5Z44_RS01150	ENOG4107VQW	regulatoR
E5Z44_RS01180	ENOG4105K56	Transcriptional regulator
E5Z44_RS01185	ENOG4105DQQ	Major facilitator superfamily MFS_1
E5Z44_RS01195	ENOG4105BZU	Histidine kinase
E5Z44_RS01215	ENOG4108IUE	nitrate reductase beta subunit
E5Z44_RS01225	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E5Z44_RS01230	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
E5Z44_RS01235	ENOG4108IFG	nitrite reductase, (NAD(P)H)
E5Z44_RS01245	ENOG4105TMB	Formate nitrite transporter
E5Z44_RS01255	ENOG4105DA5	(ABC) transporter
E5Z44_RS01290	ENOG4108RMH	femAB family
E5Z44_RS01295	ENOG4105CDA	abc transporter atp-binding protein
E5Z44_RS01300	ENOG4105DRP	amino acid AbC transporter
E5Z44_RS01305	ENOG4105EAB	amino acid AbC transporter
E5Z44_RS01320	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E5Z44_RS01340	ENOG4105BZW	Glycerate kinase
E5Z44_RS01350	ENOG4105C2C	drug resistance transporter, Bcr CflA
E5Z44_RS01370	ENOG4105C85	amino acid
E5Z44_RS01375	ENOG4105EEQ	Na H antiporter
E5Z44_RS01385	ENOG4105C0X	amino acid
E5Z44_RS01390	ENOG4105ED2	Beta-lactamase
E5Z44_RS01395	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E5Z44_RS01405	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
E5Z44_RS01410	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E5Z44_RS01420	ENOG4108HRK	Histidine kinase
E5Z44_RS01425	ENOG4105DY9	regulatoR
E5Z44_RS01430	ENOG4105Z9F	murein hydrolase regulator LrgA
E5Z44_RS01435	ENOG41067MG	lrgb family
E5Z44_RS01465	ENOG4105R40	Glycine betaine carnitine choline
E5Z44_RS01490	ENOG4105CZ9	Domain of unknown function (DU1801)
E5Z44_RS01495	ENOG4105EBR	Carboxylesterase
E5Z44_RS01500	ENOG4105F27	Major Facilitator
E5Z44_RS01510	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E5Z44_RS01520	ENOG4105C4B	ABC transporter, permease
E5Z44_RS01525	ENOG41083J0	(ABC) transporter
E5Z44_RS01540	ENOG4105CBC	glutamate synthase
E5Z44_RS01545	ENOG4105CGH	5'-nucleotidase
E5Z44_RS01560	ENOG4105D5T	phosphonate abc transporter
E5Z44_RS01585	ENOG4105CN9	Peptidase m42 family protein
E5Z44_RS01590	ENOG4105CFC	Transporter
E5Z44_RS01595	ENOG4107R33	ppx gppa phosphatase
E5Z44_RS01600	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
E5Z44_RS01610	ENOG4105EMU	Dehydrogenase
E5Z44_RS01630	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
E5Z44_RS01635	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
E5Z44_RS01650	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E5Z44_RS01655	ENOG4105C6Z	Gluconate
E5Z44_RS01660	ENOG4105CMG	Carbohydrate kinase
E5Z44_RS01665	ENOG4105G3Z	GntR family transcriptional regulator
E5Z44_RS01685	ENOG4105NRR	Uncharacterized protein conserved in bacteria (DUF2188)
E5Z44_RS01700	ENOG4105DJB	Major Facilitator Superfamily
E5Z44_RS01720	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
E5Z44_RS01730	ENOG4107T5V	SNARE associated Golgi
E5Z44_RS01735	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
E5Z44_RS01745	ENOG4108K88	Membrane
E5Z44_RS01750	ENOG4105FBA	Phospholipase Carboxylesterase
E5Z44_RS01755	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
E5Z44_RS01765	ENOG41090MY	MarR family Transcriptional regulator
E5Z44_RS01785	ENOG410830R	acetyltransferase
E5Z44_RS01790	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
E5Z44_RS01795	ENOG4105C26	Dehydrogenase
E5Z44_RS01805	ENOG4108RCM	Nitroreductase
E5Z44_RS01810	ENOG4105C5I	Dehydrogenase
E5Z44_RS01815	ENOG4108HCJ	Hydrolase
E5Z44_RS01820	ENOG4108M1Z	surface protein
E5Z44_RS01825	ENOG4108Z6X	(sortase) family
E5Z44_RS01830	ENOG4108Z7F	N-acetyltransferase
E5Z44_RS01835	ENOG4105EJQ	L-serine dehydratase
E5Z44_RS01850	ENOG4105CMG	Carbohydrate kinase
E5Z44_RS01870	ENOG4105N98	Capsule biosynthesis protein capB
E5Z44_RS01885	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E5Z44_RS01890	ENOG4105XXY	Thioredoxin
E5Z44_RS01910	ENOG41067MG	lrgb family
E5Z44_RS01915	ENOG4105VAW	lrga family
E5Z44_RS01920	ENOG4105CMU	LysR family (Transcriptional regulator
E5Z44_RS01930	ENOG4105VRS	hydrolase family 18
E5Z44_RS01940	ENOG4105CHU	acetyl-coa acetyltransferase
E5Z44_RS01945	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
E5Z44_RS01980	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
E5Z44_RS01985	ENOG4105D7N	magnesium and cobalt transport protein CorA
E5Z44_RS01995	ENOG4105EYF	MMPL domain protein
E5Z44_RS02005	ENOG4105C26	Dehydrogenase
E5Z44_RS02010	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E5Z44_RS02015	ENOG4107SJB	teichoic acid biosynthesis
E5Z44_RS02020	ENOG4108UW5	maltose o-acetyltransferase
E5Z44_RS02030	ENOG4105C59	p-type ATPase
E5Z44_RS02035	ENOG410681U	heavy metal transport detoxification protein
E5Z44_RS02040	ENOG4105C5I	Dehydrogenase
E5Z44_RS02060	ENOG4105CSR	polyphosphate kinase 2
E5Z44_RS02065	ENOG4105K78	MarR family Transcriptional regulator
E5Z44_RS02075	ENOG4105C85	amino acid
E5Z44_RS02135	ENOG4108SXP	alpha beta
E5Z44_RS02140	ENOG4105FGM	Fructosamine kinase
E5Z44_RS02145	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E5Z44_RS02170	ENOG4107FQX	Alpha-acetolactate decarboxylase
E5Z44_RS02180	ENOG4105CMU	LysR family (Transcriptional regulator
E5Z44_RS02185	ENOG4105CUB	amino acid
E5Z44_RS02195	ENOG4107VDP	teichoic acid biosynthesis
E5Z44_RS02205	ENOG41088M2	Glycosyl transferase family 2
E5Z44_RS02210	ENOG4108JPW	Aminotransferase
E5Z44_RS02215	ENOG4105D01	(LipO)protein
E5Z44_RS02230	ENOG4105WYW	fructose-bisphosphate aldolase
E5Z44_RS02235	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
E5Z44_RS02255	ENOG4105CS2	ec 3.2.1.21
E5Z44_RS02260	ENOG4105C5Y	PTS System
E5Z44_RS02265	ENOG4108S3Y	transcriptional regulator
E5Z44_RS02270	ENOG4105DWT	malate dehydrogenase (quinone)
E5Z44_RS02275	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E5Z44_RS02280	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E5Z44_RS02285	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E5Z44_RS02305	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
E5Z44_RS02310	ENOG4105C26	Dehydrogenase
E5Z44_RS02315	ENOG4105TRT	Transcriptional regulator
E5Z44_RS02320	ENOG4105C94	Transporter
E5Z44_RS02325	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
E5Z44_RS02330	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
E5Z44_RS02335	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
E5Z44_RS02350	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
E5Z44_RS02355	ENOG4107RIQ	Sulfate adenylate transferase
E5Z44_RS02360	ENOG410635A	Membrane
E5Z44_RS02365	ENOG4108Z73	Siroheme synthase
E5Z44_RS02370	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E5Z44_RS02375	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
E5Z44_RS02380	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
E5Z44_RS02390	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
E5Z44_RS02390	ENOG4105DUY	Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein
E5Z44_RS02395	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
E5Z44_RS02425	ENOG4105C19	ABC transporter
E5Z44_RS02445	ENOG4105G6Z	alkaline phosphatase
E5Z44_RS02450	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
E5Z44_RS02460	ENOG4105CMR	udp-glucose 4-epimerase
E5Z44_RS02495	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
E5Z44_RS02525	ENOG4105HTX	biosynthesis protein
E5Z44_RS02535	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
E5Z44_RS02540	ENOG4105K7W	phage-related replication protein
E5Z44_RS02545	ENOG4105PNM	synthesis protein
E5Z44_RS02550	ENOG4107UWA	esterase
E5Z44_RS02555	ENOG4105CEU	Arginine dihydrolase
E5Z44_RS02590	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E5Z44_RS02595	ENOG4108FPN	Integrase
E5Z44_RS02615	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
E5Z44_RS02645	ENOG4105VZ8	Transcriptional regulator
E5Z44_RS02655	ENOG4108JJB	ABC transporter
E5Z44_RS02665	ENOG4108RVA	ribokinase
E5Z44_RS02680	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
E5Z44_RS02685	ENOG4105C72	UPF0176 protein
E5Z44_RS02700	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
E5Z44_RS02710	ENOG4107QHE	Choloylglycine hydrolase
E5Z44_RS02730	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
E5Z44_RS02765	ENOG4105D9N	nucleoside
E5Z44_RS02775	ENOG4107RJ1	sodium solute
E5Z44_RS02780	ENOG4107SCR	N-acetylneuraminate lyase
E5Z44_RS02785	ENOG4105DKQ	ROK family
E5Z44_RS02790	ENOG4106KNT	transcriptional regulator
E5Z44_RS02795	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
E5Z44_RS02800	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E5Z44_RS02810	ENOG4105CE4	GlcNAc 6-P deacetylase
E5Z44_RS02830	ENOG4105DEN	Luciferase family
E5Z44_RS02885	ENOG4105D5Q	Arginine ornithine antiporter
E5Z44_RS02895	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
E5Z44_RS02935	ENOG4106A3M	Cytochrome p-450
E5Z44_RS02940	ENOG4105DG6	mannose-6-phosphate isomerase
E5Z44_RS02945	ENOG4105DM4	PTS System
E5Z44_RS02970	ENOG4105K7K	Transcriptional regulator
E5Z44_RS02985	ENOG4107RUY	(E1 component), alpha subunit
E5Z44_RS03000	ENOG4105C87	Aminotransferase class I and II
E5Z44_RS03015	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E5Z44_RS03020	ENOG4105C57	major facilitator superfamily
E5Z44_RS03045	ENOG4105CI1	PTS System
E5Z44_RS03055	ENOG4105CHR	reductase
E5Z44_RS03060	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
E5Z44_RS03075	ENOG4107QNK	)-transporter
E5Z44_RS03090	ENOG4108YYC	ycei family
E5Z44_RS03100	ENOG4105CJ1	ABC, transporter
E5Z44_RS03115	ENOG4107RA9	decarboxylase
E5Z44_RS03120	ENOG4105EFJ	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS03125	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS03130	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS03135	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS03140	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
E5Z44_RS03145	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E5Z44_RS03170	ENOG4105CJ1	ABC, transporter
E5Z44_RS03185	ENOG4105C2C	drug resistance transporter, Bcr CflA
E5Z44_RS03205	ENOG4105EWK	phytoene
E5Z44_RS03215	ENOG4105KAV	tspo and mbr like protein
E5Z44_RS03220	ENOG4105DHF	Membrane
E5Z44_RS03240	ENOG4105CHR	reductase
E5Z44_RS03270	ENOG4105F1A	Pyruvate formate-lyase
E5Z44_RS03285	ENOG4105CMR	udp-glucose 4-epimerase
E5Z44_RS03290	ENOG4105EYF	MMPL domain protein
E5Z44_RS03335	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E5Z44_RS03340	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E5Z44_RS03345	ENOG4107QTZ	amino acid
E5Z44_RS03350	ENOG4108V4B	ThiJ pfpI
E5Z44_RS03365	ENOG4108S9F	abc transporter, atp-binding protein
E5Z44_RS03370	ENOG4108RZA	ABC transporter
E5Z44_RS03380	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS03395	ENOG4105C54	Major Facilitator superfamily
E5Z44_RS03400	ENOG4108HCJ	Hydrolase
E5Z44_RS03405	ENOG4106F1P	AAA ATPase, central domain protein
E5Z44_RS03415	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
E5Z44_RS03430	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E5Z44_RS03435	ENOG4105D38	putrescine abc transporter
E5Z44_RS03440	ENOG4105C4Y	ABC transporter
E5Z44_RS03445	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS03450	ENOG4105DUM	transcriptional regulator, lysR family
E5Z44_RS03485	ENOG4108YBA	Histidine kinase
E5Z44_RS03490	ENOG4105CVJ	phosphoglycerate mutase
E5Z44_RS03495	ENOG4105E98	transcriptional regulator DeoR family
E5Z44_RS03500	ENOG4105UQX	Mate efflux family protein
E5Z44_RS03510	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS03525	ENOG4108IJ9	(ABC) transporter
E5Z44_RS03530	ENOG4108KF8	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E5Z44_RS03535	ENOG4108U05	Transcriptional regulator
E5Z44_RS03550	ENOG4108MES	Periplasmic binding protein
E5Z44_RS03555	ENOG4105DQ5	transport system permease protein
E5Z44_RS03560	ENOG4108IHU	transport system permease protein
E5Z44_RS03565	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
E5Z44_RS03575	ENOG4105KFN	sortase, SrtB family
E5Z44_RS03580	ENOG4105E0A	ABC, transporter
E5Z44_RS03595	ENOG4106ST0	Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)
E5Z44_RS03610	ENOG4108JJB	ABC transporter
E5Z44_RS03630	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
E5Z44_RS03635	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E5Z44_RS03640	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E5Z44_RS03650	ENOG4105C08	Histidine kinase
E5Z44_RS03655	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
E5Z44_RS03665	ENOG4105F3R	pts system mannose fructose sorbose family iid
E5Z44_RS03670	ENOG4105ETZ	PTS System
E5Z44_RS03675	ENOG4108UZY	PTS System
E5Z44_RS03680	ENOG4105D2M	Aldolase
E5Z44_RS03685	ENOG4105E70	isomerase
E5Z44_RS03690	ENOG4108X79	transcriptional regulator
E5Z44_RS03740	ENOG4105DA5	(ABC) transporter
E5Z44_RS03755	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E5Z44_RS03795	ENOG4108JJB	ABC transporter
E5Z44_RS03825	ENOG4105ENX	hydrolase
E5Z44_RS03835	ENOG4108QYW	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity)
E5Z44_RS03860	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E5Z44_RS03865	ENOG4105Q2H	domain protein
E5Z44_RS03870	ENOG4105E2D	ec 3.2.1.52
E5Z44_RS03875	ENOG4107QJZ	Glycosyl transferase, family 2
E5Z44_RS03885	ENOG4107UVV	polysaccharide deacetylase
E5Z44_RS03905	ENOG4105BZU	Histidine kinase
E5Z44_RS03910	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E5Z44_RS03925	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E5Z44_RS03930	ENOG4105CDU	Replicative dna helicase
E5Z44_RS03935	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E5Z44_RS03940	ENOG4105BZR	domain protein
E5Z44_RS03950	ENOG4105DWV	Homoserine O-trans-acetylase
E5Z44_RS03960	ENOG4108UMN	azlc family
E5Z44_RS03970	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E5Z44_RS03975	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E5Z44_RS03980	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E5Z44_RS03985	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E5Z44_RS03990	ENOG410848D	S4 domain protein YaaA
E5Z44_RS03995	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E5Z44_RS04000	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E5Z44_RS04010	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E5Z44_RS04015	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E5Z44_RS04020	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E5Z44_RS04045	ENOG41067SE	Tetr family transcriptional regulator
E5Z44_RS04050	ENOG4105CPQ	Dehydrogenase
E5Z44_RS04060	ENOG4105IE8	Alpha-ketoglutarate permease
E5Z44_RS04065	ENOG4105CHR	reductase
E5Z44_RS04090	ENOG4105C19	ABC transporter
E5Z44_RS04095	ENOG4105C3F	Signal peptidase i
E5Z44_RS04105	ENOG4105CXY	transporter
E5Z44_RS04115	ENOG4108XI2	Domain of unknown function (DUF1963)
E5Z44_RS04125	ENOG4105ETE	Transcriptional regulator (LacI family
E5Z44_RS04130	ENOG4108HKT	sucrose-6-phosphate hydrolase
E5Z44_RS04135	ENOG4105U0F	oligosaccharide H symporter, major facilitator superfamily (MFS)
E5Z44_RS04140	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E5Z44_RS04175	ENOG4105C19	ABC transporter
E5Z44_RS04180	ENOG4107RBB	ABC transporter, permease
E5Z44_RS04195	ENOG4107T5J	pyridine nucleotide-disulfide oxidoreductase
E5Z44_RS04205	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
E5Z44_RS04215	ENOG4105C28	cystathionine
E5Z44_RS04220	ENOG4105C28	cystathionine
E5Z44_RS04225	ENOG4105FA0	parb-like partition protein
E5Z44_RS04230	ENOG4105D8X	mechanosensitive ion channel
E5Z44_RS04235	ENOG4105VDK	protein, conserved in bacteria
E5Z44_RS04240	ENOG4105C3G	gtp-binding protein
E5Z44_RS04255	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E5Z44_RS04260	ENOG4108UUM	single-stranded DNA-binding protein
E5Z44_RS04265	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E5Z44_RS04340	ENOG4108TFU	terminase (Small subunit)
E5Z44_RS04380	ENOG4108TGR	phosphatase
E5Z44_RS04395	ENOG4108JU3	Alkyl hydroperoxide reductase
E5Z44_RS04400	ENOG4105D3R	alkyl hydroperoxide reductase
E5Z44_RS04410	ENOG4108DBC	nitroreductase
E5Z44_RS04415	ENOG4107R6U	sodium dicarboxylate symporter
E5Z44_RS04435	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
E5Z44_RS04440	ENOG4105C2W	permease
E5Z44_RS04445	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E5Z44_RS04450	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E5Z44_RS04470	ENOG4105CKI	cobalamin synthesis protein
E5Z44_RS04480	ENOG4108TWJ	NADH dehydrogenase subunit 5
E5Z44_RS04485	ENOG4105EVH	UPF0753 protein
E5Z44_RS04490	ENOG4105GPN	Uncharacterized conserved protein (DUF2294)
E5Z44_RS04510	ENOG4105C8J	)-transporter
E5Z44_RS04525	ENOG4105C28	cystathionine
E5Z44_RS04540	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS04545	ENOG4108UMI	ABC transporter, permease
E5Z44_RS04550	ENOG4105D01	(LipO)protein
E5Z44_RS04580	ENOG4105C5Q	Transcriptional regulator
E5Z44_RS04585	ENOG4105CBC	glutamate synthase
E5Z44_RS04590	ENOG4105BZ8	glutamate synthase
E5Z44_RS04600	ENOG4105C5Y	PTS System
E5Z44_RS04605	ENOG4105CG3	alpha amylase, catalytic region
E5Z44_RS04610	ENOG4107414	GntR family transcriptional regulator
E5Z44_RS04625	ENOG4105C6E	dna polymerase iii
E5Z44_RS04630	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E5Z44_RS04635	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E5Z44_RS04670	ENOG4105CXN	decarboxylase
E5Z44_RS04675	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E5Z44_RS04680	ENOG4105X0R	protein from nitrogen regulatory protein P-II
E5Z44_RS04685	ENOG4105FA2	dna polymerase iii
E5Z44_RS04690	ENOG4105MA4	psp1 domain protein
E5Z44_RS04700	ENOG41060K3	Methyltransferase
E5Z44_RS04710	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E5Z44_RS04715	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E5Z44_RS04720	ENOG4105F8V	Hydrolase, tatD family
E5Z44_RS04725	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
E5Z44_RS04730	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E5Z44_RS04735	ENOG4105W42	Veg protein
E5Z44_RS04740	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E5Z44_RS04745	ENOG4105DFT	pur operon repressor
E5Z44_RS04750	ENOG4105KME	endoribonuclease L-psp
E5Z44_RS04760	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E5Z44_RS04765	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E5Z44_RS04775	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E5Z44_RS04780	ENOG4108JA2	transcriptioN-repair coupling factor
E5Z44_RS04790	ENOG4108IY2	MazG family
E5Z44_RS04795	ENOG41082I2	s4 domain protein
E5Z44_RS04805	ENOG41060GV	RNA binding s1 domain protein
E5Z44_RS04810	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
E5Z44_RS04815	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E5Z44_RS04820	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E5Z44_RS04830	ENOG4105C6T	cysteine synthase
E5Z44_RS04840	ENOG4105KRF	dihydroneopterin aldolase
E5Z44_RS04845	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5Z44_RS04850	ENOG4105CRK	lysyL-tRNA synthetase
E5Z44_RS04935	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E5Z44_RS04940	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
E5Z44_RS04945	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
E5Z44_RS04950	ENOG4105D9N	nucleoside
E5Z44_RS04955	ENOG4105KEX	transcriptional regulator, ctsr
E5Z44_RS04960	ENOG4108Z0C	Uvrb UvrC protein
E5Z44_RS04965	ENOG41066A3	ATP guanido phosphotransferase
E5Z44_RS04970	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E5Z44_RS04975	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
E5Z44_RS04980	ENOG4105CTP	PilT protein domain protein
E5Z44_RS04985	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E5Z44_RS04990	ENOG4105D7W	serine acetyltransferase
E5Z44_RS04995	ENOG4105C8N	cysteinyl-tRNA synthetase
E5Z44_RS05000	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E5Z44_RS05005	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E5Z44_RS05010	ENOG4105M0M	Tetracycline resistance protein
E5Z44_RS05025	ENOG410683Z	Preprotein translocase SecE subunit
E5Z44_RS05030	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E5Z44_RS05040	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E5Z44_RS05045	ENOG4108VZM	50s ribosomal protein L10
E5Z44_RS05050	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E5Z44_RS05055	ENOG4107Y49	methyltransferase
E5Z44_RS05060	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E5Z44_RS05065	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E5Z44_RS05075	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E5Z44_RS05090	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E5Z44_RS05115	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E5Z44_RS05120	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
E5Z44_RS05130	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E5Z44_RS05135	ENOG4107R7I	amino acid
E5Z44_RS05140	ENOG4105C7B	Threonine dehydratase
E5Z44_RS05155	ENOG4105ZMH	deoxynucleoside kinase
E5Z44_RS05165	ENOG4108Z6B	deaminase
E5Z44_RS05170	ENOG410667J	hydrolase
E5Z44_RS05195	ENOG4107SJB	teichoic acid biosynthesis
E5Z44_RS05205	ENOG4107YEI	lmbE family
E5Z44_RS05215	ENOG4108VA3	3-hexulose-6-phosphate synthase
E5Z44_RS05220	ENOG41080HJ	6-phospho 3-hexuloisomerase
E5Z44_RS05235	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
E5Z44_RS05245	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
E5Z44_RS05250	ENOG4105DWF	phosphomethylpyrimidine kinase
E5Z44_RS05260	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E5Z44_RS05270	ENOG4105M08	Membrane
E5Z44_RS05275	ENOG4105CUB	amino acid
E5Z44_RS05305	ENOG4107JTW	chlorite dismutase
E5Z44_RS05310	ENOG4108IJ2	phosphate acetyltransferase
E5Z44_RS05315	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
E5Z44_RS05335	ENOG4105QAT	UPF0741 protein
E5Z44_RS05340	ENOG4107QN2	dihydrolipoyl dehydrogenase
E5Z44_RS05350	ENOG4105CPC	Aldo Keto reductase
E5Z44_RS05355	ENOG4108WS4	fmn reductase
E5Z44_RS05365	ENOG4105DCI	Phosphohydrolase
E5Z44_RS05370	ENOG4108XFG	YwhD family
E5Z44_RS05375	ENOG4105DQ4	alcohol dehydrogenase
E5Z44_RS05395	ENOG4105C75	arginyL-tRNA synthetase
E5Z44_RS05415	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
E5Z44_RS05420	ENOG4105EHG	Permease protein
E5Z44_RS05445	ENOG4105F2Z	3-oxoadipate enol-lactonase
E5Z44_RS05475	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E5Z44_RS05480	ENOG4105C8S	subunit m
E5Z44_RS05485	ENOG4108PMQ	Na H antiporter MnhB subunit-related protein
E5Z44_RS05495	ENOG4108JPZ	Monovalent cation H antiporter subunit D
E5Z44_RS05500	ENOG4105IMY	monovalent cation H antiporter subunit E
E5Z44_RS05505	ENOG410684G	monovalent cation H antiporter subunit F
E5Z44_RS05510	ENOG4105KJM	monovalent cation h antiporter subunit g
E5Z44_RS05515	ENOG4105EEQ	Na H antiporter
E5Z44_RS05520	ENOG4105DSE	periplasmic solute binding protein
E5Z44_RS05525	ENOG4105CC5	ABC transporter
E5Z44_RS05530	ENOG4105DIK	(ABC) transporter
E5Z44_RS05535	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
E5Z44_RS05545	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
E5Z44_RS05560	ENOG4105EY8	ABC transporter
E5Z44_RS05580	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
E5Z44_RS05590	ENOG4105BZ1	(ABC) transporter
E5Z44_RS05595	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
E5Z44_RS05600	ENOG4107SJB	teichoic acid biosynthesis
E5Z44_RS05620	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
E5Z44_RS05625	ENOG4105E0A	ABC, transporter
E5Z44_RS05630	ENOG4105DQ5	transport system permease protein
E5Z44_RS05635	ENOG4105EHG	Permease protein
E5Z44_RS05640	ENOG4105VDH	Dihydroxyacetone kinase
E5Z44_RS05650	ENOG4108K88	Membrane
E5Z44_RS05670	ENOG4105CJZ	response regulator
E5Z44_RS05675	ENOG4105EWM	Histidine kinase
E5Z44_RS05680	ENOG4105C19	ABC transporter
E5Z44_RS05690	ENOG4107GRR	phosphate transport regulator
E5Z44_RS05695	ENOG4105CJ3	phosphate transporter
E5Z44_RS05700	ENOG4105VRS	hydrolase family 18
E5Z44_RS05720	ENOG4105CDY	transcriptional regulatory protein
E5Z44_RS05740	ENOG4105S8Q	sugar efflux transporter
E5Z44_RS05745	ENOG4105SXS	Protein of unknown function (DUF456)
E5Z44_RS05770	ENOG4108URH	decarboxylase
E5Z44_RS05775	ENOG4107XJU	UPF0178 protein
E5Z44_RS05790	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E5Z44_RS05795	ENOG41083AI	transcriptional regulator), MarR family
E5Z44_RS05800	ENOG4105CKI	cobalamin synthesis protein
E5Z44_RS05815	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E5Z44_RS05820	ENOG4107QPK	)-transporter
E5Z44_RS05825	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E5Z44_RS05850	ENOG4108Z66	YbaK ebsC protein
E5Z44_RS05855	ENOG4105E98	transcriptional regulator DeoR family
E5Z44_RS05860	ENOG4105DE4	1-phosphofructokinase
E5Z44_RS05865	ENOG4105DM4	PTS System
E5Z44_RS05870	ENOG4105C37	(CBS) domain
E5Z44_RS05880	ENOG4105CKK	Glycosyl transferase, family 2
E5Z44_RS05890	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E5Z44_RS05895	ENOG4107ZAE	6-carboxy-5,6,7,8-tetrahydropterin synthase
E5Z44_RS05905	ENOG4105DDQ	anthranilate synthase
E5Z44_RS05920	ENOG4105P4J	Allophanate hydrolase, subunit 1
E5Z44_RS05935	ENOG4108RS6	transposase
E5Z44_RS05945	ENOG4105C5H	ABC transporter
E5Z44_RS05950	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E5Z44_RS05960	ENOG4105E90	ABC transporter
E5Z44_RS05965	ENOG4105DUX	Transporter
E5Z44_RS05970	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E5Z44_RS05975	ENOG4108ZIE	5 nucleotidase deoxy cytosolic type C
E5Z44_RS05980	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
E5Z44_RS05985	ENOG4105DUX	Transporter
E5Z44_RS05990	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E5Z44_RS06000	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
E5Z44_RS06005	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E5Z44_RS06010	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E5Z44_RS06015	ENOG4105DHS	permease protein
E5Z44_RS06020	ENOG4105CM4	permease protein
E5Z44_RS06025	ENOG4108IPW	abc transporter atp-binding protein
E5Z44_RS06035	ENOG4105DHS	permease protein
E5Z44_RS06040	ENOG4105CM4	permease protein
E5Z44_RS06045	ENOG4108IPW	abc transporter atp-binding protein
E5Z44_RS06060	ENOG4105D4A	Cell wall formation (By similarity)
E5Z44_RS06080	ENOG4105BZW	Glycerate kinase
E5Z44_RS06090	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E5Z44_RS06105	ENOG4105BZU	Histidine kinase
E5Z44_RS06110	ENOG4105ESV	Glycosyl transferase, family 4
E5Z44_RS06115	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E5Z44_RS06130	ENOG41081UC	Inherit from COG: Competence protein
E5Z44_RS06135	ENOG4105MS2	ribosomal subunit Interface protein
E5Z44_RS06140	ENOG410907Z	n-acetylmuramoyl-l-alanine amidase
E5Z44_RS06145	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E5Z44_RS06155	ENOG41068JE	domain protein
E5Z44_RS06175	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E5Z44_RS06180	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
E5Z44_RS06185	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E5Z44_RS06200	ENOG4105C3M	thioredoxin reductase
E5Z44_RS06205	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E5Z44_RS06210	ENOG4105CHW	UPF0052 protein
E5Z44_RS06215	ENOG4105CIE	May be required for sporulation (By similarity)
E5Z44_RS06220	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E5Z44_RS06225	ENOG4105ECP	epimerase
E5Z44_RS06245	ENOG4105BZA	Phosphoglycerate kinase
E5Z44_RS06250	ENOG4105CP7	Triose-phosphate isomerase
E5Z44_RS06255	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E5Z44_RS06260	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E5Z44_RS06270	ENOG4105XZU	Preprotein translocase, subunit SecG
E5Z44_RS06280	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E5Z44_RS06310	ENOG41088ZC	Negative regulator of protease production and sporulation (By similarity)
E5Z44_RS06325	ENOG4105PGM	cation diffusion facilitator family transporter
E5Z44_RS06335	ENOG4106QP9	(LipO)protein
E5Z44_RS06375	ENOG4108URH	decarboxylase
E5Z44_RS06385	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
E5Z44_RS06405	ENOG4105K7W	phage-related replication protein
E5Z44_RS06435	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E5Z44_RS06445	ENOG4108ZHJ	Organic hydroperoxide resistance protein
E5Z44_RS06450	ENOG4105FF2	Type I DHQase
E5Z44_RS06460	ENOG4105SZ6	Thioredoxin
E5Z44_RS06465	ENOG41080E8	Transcriptional regulator, Spx MgsR family
E5Z44_RS06470	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E5Z44_RS06485	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS06490	ENOG4108UMI	ABC transporter, permease
E5Z44_RS06495	ENOG4105D01	(LipO)protein
E5Z44_RS06515	ENOG4105C3K	feS assembly ATPase SufC
E5Z44_RS06520	ENOG4105JRK	feS assembly protein SufD
E5Z44_RS06525	ENOG4105C9B	Cysteine desulfurase
E5Z44_RS06530	ENOG4108UNV	SUF system FeS assembly protein, NifU family
E5Z44_RS06535	ENOG4105DIW	FeS assembly protein SUFB
E5Z44_RS06565	ENOG4105VRS	hydrolase family 18
E5Z44_RS06585	ENOG4106GSS	Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity)
E5Z44_RS06725	ENOG4105EA8	2-Nitropropane dioxygenase
E5Z44_RS06730	ENOG4105I3N	Conserved Protein
E5Z44_RS06740	ENOG4107R8B	5'-nucleotidase
E5Z44_RS06745	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E5Z44_RS06750	ENOG4105MMD	transcriptional regulator
E5Z44_RS06765	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
E5Z44_RS06770	ENOG4105C5I	Dehydrogenase
E5Z44_RS06780	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
E5Z44_RS06785	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
E5Z44_RS06790	ENOG4106C1H	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
E5Z44_RS06795	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
E5Z44_RS06800	ENOG41083MR	nifu domain-containing protein
E5Z44_RS06815	ENOG4105ZKE	UPF0349 protein
E5Z44_RS06820	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E5Z44_RS06835	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
E5Z44_RS06840	ENOG4105C0W	non-ribosomal peptide synthetase
E5Z44_RS06870	ENOG4108JJB	ABC transporter
E5Z44_RS06880	ENOG4105BZ1	(ABC) transporter
E5Z44_RS06890	ENOG4105CEP	NADH dehydrogenase
E5Z44_RS06895	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E5Z44_RS06905	ENOG4105KA0	thioesterase Superfamily protein
E5Z44_RS06915	ENOG4105KJM	monovalent cation h antiporter subunit g
E5Z44_RS06920	ENOG4105W4C	monovalent cation H antiporter subunit F
E5Z44_RS06925	ENOG4105SC1	monovalent cation H antiporter subunit E
E5Z44_RS06930	ENOG4108JPZ	Monovalent cation H antiporter subunit D
E5Z44_RS06935	ENOG4105MKQ	Monovalent cation H antiporter subunit C
E5Z44_RS06945	ENOG4105D65	subunit l
E5Z44_RS06955	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E5Z44_RS06960	ENOG41060GV	RNA binding s1 domain protein
E5Z44_RS06965	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E5Z44_RS06970	ENOG4105D82	Glutamate dehydrogenase
E5Z44_RS06995	ENOG4105CDH	Citrulline--aspartate ligase
E5Z44_RS07000	ENOG4107QYV	phosphohexose isomerase
E5Z44_RS07025	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E5Z44_RS07040	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E5Z44_RS07045	ENOG4108KP7	hydrolase
E5Z44_RS07055	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E5Z44_RS07065	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E5Z44_RS07070	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E5Z44_RS07080	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS07085	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E5Z44_RS07095	ENOG4108JQ7	(ABC) transporter
E5Z44_RS07105	ENOG4105DVA	methyltransferase
E5Z44_RS07110	ENOG4105C31	Tryptophanyl-tRNA synthetase
E5Z44_RS07115	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
E5Z44_RS07130	ENOG4105DPN	Oligoendopeptidase f
E5Z44_RS07135	ENOG4105T58	Dithiol-disulfide isomerase
E5Z44_RS07140	ENOG4108Z18	K06886 hemoglobin
E5Z44_RS07150	ENOG4106EFP	UPF0738 protein
E5Z44_RS07165	ENOG4105EMS	pseudouridine synthase
E5Z44_RS07170	ENOG4105CJW	magnesium transporter
E5Z44_RS07185	ENOG4105C02	permease
E5Z44_RS07195	ENOG4105EMU	Dehydrogenase
E5Z44_RS07200	ENOG4105W1Y	Transcriptional regulator
E5Z44_RS07210	ENOG4108PK2	permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence
E5Z44_RS07215	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
E5Z44_RS07220	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E5Z44_RS07235	ENOG4107TS3	membrane protein, TerC
E5Z44_RS07240	ENOG4105C0H	protease
E5Z44_RS07250	ENOG4105CGH	5'-nucleotidase
E5Z44_RS07330	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
E5Z44_RS07335	ENOG4105E4F	Isochorismate synthase
E5Z44_RS07340	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
E5Z44_RS07345	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
E5Z44_RS07350	ENOG4108IPT	Naphthoate synthase
E5Z44_RS07355	ENOG4105CHM	Aminotransferase
E5Z44_RS07360	ENOG4108TGC	Acyltransferase
E5Z44_RS07370	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
E5Z44_RS07375	ENOG41082BV	acetyltransferase
E5Z44_RS07390	ENOG4108KGH	TRANSCRIPTIONal
E5Z44_RS07395	ENOG4105FQP	Beta-lactamase
E5Z44_RS07405	ENOG41060D1	Quinol oxidase
E5Z44_RS07410	ENOG4105CCU	oxidase (Subunit III)
E5Z44_RS07420	ENOG4105E2S	oxidase) subunit II
E5Z44_RS07430	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E5Z44_RS07440	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E5Z44_RS07445	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E5Z44_RS07450	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E5Z44_RS07455	ENOG4105C8V	SAICAR synthetase
E5Z44_RS07460	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
E5Z44_RS07465	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
E5Z44_RS07470	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
E5Z44_RS07475	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E5Z44_RS07480	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E5Z44_RS07485	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E5Z44_RS07490	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E5Z44_RS07495	ENOG4105C12	Phosphoribosylglycinamide synthetase
E5Z44_RS07500	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
E5Z44_RS07505	ENOG4108JJB	ABC transporter
E5Z44_RS07520	ENOG4105DR4	Methyltransferase
E5Z44_RS07530	ENOG4105KRI	phosphocarrier protein (HPr
E5Z44_RS07550	ENOG4107ZYR	domain protein
E5Z44_RS07560	ENOG4105CN5	Metallo-Beta-Lactamase
E5Z44_RS07565	ENOG4106148	UPF0356 protein
E5Z44_RS07570	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E5Z44_RS07585	ENOG4105CPP	Dehydrogenase, E1 component
E5Z44_RS07590	ENOG4105C7S	Dehydrogenase
E5Z44_RS07595	ENOG4107QN2	dihydrolipoyl dehydrogenase
E5Z44_RS07600	ENOG4105WBI	UPF0223 protein
E5Z44_RS07620	ENOG4105D38	putrescine abc transporter
E5Z44_RS07625	ENOG4107RUE	extracellular solute-binding protein family 1
E5Z44_RS07645	ENOG4108WQ8	UPF0637 protein
E5Z44_RS07650	ENOG4105ECY	inositol monophosphatase
E5Z44_RS07660	ENOG4105CI3	gtp-binding protein typa
E5Z44_RS07675	ENOG4105ZPI	UPF0358 protein
E5Z44_RS07680	ENOG4105CNI	cell division protein FtsW
E5Z44_RS07685	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
E5Z44_RS07695	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
E5Z44_RS07700	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E5Z44_RS07735	ENOG4106H78	methyltransferase
E5Z44_RS07740	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E5Z44_RS07745	ENOG4105CDE	UPF0348 protein
E5Z44_RS07755	ENOG41067VY	50S ribosomal protein L32
E5Z44_RS07760	ENOG4108RWN	rrna methyltransferase
E5Z44_RS07765	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E5Z44_RS07770	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E5Z44_RS07775	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E5Z44_RS07790	ENOG4105DCG	PHP domain protein
E5Z44_RS07795	ENOG4105C98	muts2 protein
E5Z44_RS07800	ENOG4105K63	Thioredoxin
E5Z44_RS07805	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E5Z44_RS07810	ENOG4108NU2	Succinate dehydrogenase cytochrome b558 subunit
E5Z44_RS07820	ENOG4105E33	succinate dehydrogenase
E5Z44_RS07825	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E5Z44_RS07830	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E5Z44_RS07850	ENOG4108YG3	N-acetyltransferase
E5Z44_RS07855	ENOG41074B2	UPF0747 protein
E5Z44_RS07865	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E5Z44_RS07870	ENOG41068DC	Essential cell division protein (By similarity)
E5Z44_RS07875	ENOG4105CJN	penicillin-binding protein
E5Z44_RS07880	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E5Z44_RS07885	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E5Z44_RS07890	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
E5Z44_RS07895	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E5Z44_RS07900	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E5Z44_RS07905	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E5Z44_RS07910	ENOG4105DFA	alanine racemase domain protein
E5Z44_RS07915	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
E5Z44_RS07920	ENOG41067XK	integral membrane protein
E5Z44_RS07925	ENOG4105DBK	s4 domain protein
E5Z44_RS07935	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E5Z44_RS07945	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E5Z44_RS07950	ENOG4105C34	Pseudouridine synthase
E5Z44_RS07955	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
E5Z44_RS07965	ENOG4105CXT	aspartate transcarbamylase
E5Z44_RS07970	ENOG4105CD3	dihydroorotase
E5Z44_RS07975	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E5Z44_RS07985	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E5Z44_RS07990	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E5Z44_RS08005	ENOG4105F23	Fibronectin-binding protein
E5Z44_RS08010	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E5Z44_RS08015	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E5Z44_RS08020	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E5Z44_RS08025	ENOG4105C25	Primosomal protein n'
E5Z44_RS08035	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E5Z44_RS08040	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E5Z44_RS08050	ENOG4108ZF3	Phosphatase
E5Z44_RS08060	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
E5Z44_RS08065	ENOG4105DJV	ribulose-phosphate 3-epimerase
E5Z44_RS08075	ENOG4105VB9	50S ribosomal protein l28
E5Z44_RS08080	ENOG4108ZAA	Alkaline-shock protein
E5Z44_RS08085	ENOG4105DP4	dak2 domain fusion protein ylov
E5Z44_RS08090	ENOG4105CB5	ATP-dependent DNA helicase recG
E5Z44_RS08095	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
E5Z44_RS08100	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E5Z44_RS08110	ENOG4105CHR	reductase
E5Z44_RS08115	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E5Z44_RS08120	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E5Z44_RS08125	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E5Z44_RS08130	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E5Z44_RS08135	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
E5Z44_RS08145	ENOG4108RS6	transposase
E5Z44_RS08150	ENOG4107F3J	Amp-dependent synthetase and ligase
E5Z44_RS08155	ENOG4105CHU	acetyl-coa acetyltransferase
E5Z44_RS08170	ENOG4105K5M	30s ribosomal protein S16
E5Z44_RS08175	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E5Z44_RS08180	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E5Z44_RS08185	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E5Z44_RS08195	ENOG4105EJV	Membrane
E5Z44_RS08205	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E5Z44_RS08210	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
E5Z44_RS08215	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
E5Z44_RS08220	ENOG4108RMH	femAB family
E5Z44_RS08225	ENOG4105C79	DNA protecting protein DprA
E5Z44_RS08230	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E5Z44_RS08235	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
E5Z44_RS08240	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E5Z44_RS08245	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E5Z44_RS08250	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E5Z44_RS08255	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
E5Z44_RS08260	ENOG4105CE9	30S ribosomal protein S2
E5Z44_RS08265	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E5Z44_RS08270	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E5Z44_RS08275	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E5Z44_RS08280	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E5Z44_RS08285	ENOG4105KNE	Phosphatidate cytidylyltransferase
E5Z44_RS08300	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E5Z44_RS08305	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E5Z44_RS08310	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E5Z44_RS08315	ENOG4105CHV	Transcription elongation factor NusA
E5Z44_RS08320	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
E5Z44_RS08325	ENOG4105VHM	ribosomal protein
E5Z44_RS08335	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E5Z44_RS08345	ENOG4105DTN	riboflavin biosynthesis protein ribF
E5Z44_RS08355	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E5Z44_RS08360	ENOG4105CN5	Metallo-Beta-Lactamase
E5Z44_RS08365	ENOG4105CNU	cell division protein FtsK
E5Z44_RS08370	ENOG4105FDP	GntR family transcriptional regulator
E5Z44_RS08385	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
E5Z44_RS08400	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E5Z44_RS08405	ENOG4105CEV	competence damage-inducible protein
E5Z44_RS08410	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E5Z44_RS08415	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
E5Z44_RS08425	ENOG4105D48	metallophosphoesterase
E5Z44_RS08430	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
E5Z44_RS08435	ENOG4105DQU	oxidoreductase, subunit beta
E5Z44_RS08440	ENOG4105K7W	phage-related replication protein
E5Z44_RS08455	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E5Z44_RS08470	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E5Z44_RS08475	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E5Z44_RS08490	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
E5Z44_RS08495	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
E5Z44_RS08505	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E5Z44_RS08510	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E5Z44_RS08515	ENOG4108V06	Glutathione peroxidase
E5Z44_RS08520	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E5Z44_RS08525	ENOG4105CXI	aluminum resistance protein
E5Z44_RS08530	ENOG4105KV4	Transcriptional regulator
E5Z44_RS08535	ENOG4105C5F	glutamine synthetase
E5Z44_RS08545	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E5Z44_RS08550	ENOG4108M15	ABC transporter
E5Z44_RS08560	ENOG4105BZU	Histidine kinase
E5Z44_RS08600	ENOG4105D6E	homoserine dehydrogenase
E5Z44_RS08605	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
E5Z44_RS08610	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
E5Z44_RS08615	ENOG4105J7I	hydrolase
E5Z44_RS08625	ENOG4108IQI	permease
E5Z44_RS08630	ENOG4105CH6	catalase
E5Z44_RS08640	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E5Z44_RS08650	ENOG4106UY4	Inherit from COG: Scp-like extracellular
E5Z44_RS08655	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E5Z44_RS08665	ENOG4105VPS	UPF0291 protein
E5Z44_RS08670	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E5Z44_RS08675	ENOG4105VXM	UPF0154 protein
E5Z44_RS08690	ENOG4105EYH	Exonuclease
E5Z44_RS08695	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E5Z44_RS08700	ENOG4105C94	Transporter
E5Z44_RS08705	ENOG4108I0Z	Aconitate hydratase
E5Z44_RS08720	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E5Z44_RS08725	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E5Z44_RS08730	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E5Z44_RS08745	ENOG4105FF5	Membrane
E5Z44_RS08765	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E5Z44_RS08770	ENOG4108RCF	TRANSCRIPTIONal
E5Z44_RS08775	ENOG41069HH	4-oxalocrotonate tautomerase
E5Z44_RS08780	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E5Z44_RS08785	ENOG4105EVN	Prephenate dehydrogenase
E5Z44_RS08805	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
E5Z44_RS08815	ENOG4106ETB	IIa component
E5Z44_RS08830	ENOG4105DER	m42 family
E5Z44_RS08835	ENOG4105VND	Ribonuclease
E5Z44_RS08850	ENOG4106QQ5	PBS lyase HEAT domain protein repeat-containing protein
E5Z44_RS08855	ENOG4108Y6J	UPF0403 protein
E5Z44_RS08865	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
E5Z44_RS08875	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E5Z44_RS08880	ENOG4105E0X	reductase
E5Z44_RS08895	ENOG4105CN1	protease
E5Z44_RS08905	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E5Z44_RS08910	ENOG410841Q	phosphoesterase PA-phosphatase related protein
E5Z44_RS08915	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E5Z44_RS08920	ENOG4105GR3	Histidine kinase
E5Z44_RS08925	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E5Z44_RS08945	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
E5Z44_RS08950	ENOG4107T89	von Willebrand factor, type A
E5Z44_RS08955	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
E5Z44_RS08960	ENOG4105CDW	Resistance protein
E5Z44_RS08970	ENOG410855V	Acylphosphatase
E5Z44_RS08980	ENOG4105VEQ	Cold shock protein
E5Z44_RS08990	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E5Z44_RS08995	ENOG4108XFP	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E5Z44_RS09000	ENOG4105CH2	amidohydrolase
E5Z44_RS09005	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E5Z44_RS09010	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E5Z44_RS09015	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E5Z44_RS09020	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E5Z44_RS09025	ENOG4105CFH	Aspartokinase
E5Z44_RS09030	ENOG4105C5H	ABC transporter
E5Z44_RS09035	ENOG4105QNR	S1 RNA binding domain protein
E5Z44_RS09040	ENOG4105EXS	phosphate abc transporter
E5Z44_RS09045	ENOG4105C8U	phosphate abc transporter
E5Z44_RS09050	ENOG4105E2Z	phosphate ABC transporter (Permease
E5Z44_RS09055	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E5Z44_RS09065	ENOG4105DPN	Oligoendopeptidase f
E5Z44_RS09080	ENOG4108KP7	hydrolase
E5Z44_RS09090	ENOG4108RMH	femAB family
E5Z44_RS09105	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
E5Z44_RS09110	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E5Z44_RS09115	ENOG4108I0Q	anthranilate phosphoribosyltransferase
E5Z44_RS09120	ENOG4105DDQ	anthranilate synthase
E5Z44_RS09125	ENOG4105CRQ	synthase (Component I)
E5Z44_RS09135	ENOG410890F	Dynamin family
E5Z44_RS09145	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E5Z44_RS09155	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
E5Z44_RS09160	ENOG4108UKS	UPF0398 protein
E5Z44_RS09175	ENOG4105BZ4	penicillin-binding protein
E5Z44_RS09185	ENOG4105CSM	endonuclease III
E5Z44_RS09195	ENOG4105C5S	asparaginyl-tRNA synthetase
E5Z44_RS09200	ENOG4105DVT	helicase
E5Z44_RS09205	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E5Z44_RS09210	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E5Z44_RS09215	ENOG4105CPK	Glycosyl transferase (Group 1
E5Z44_RS09220	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
E5Z44_RS09250	ENOG4105D49	3-dehydroquinate synthase
E5Z44_RS09255	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E5Z44_RS09265	ENOG4105EAH	synthase
E5Z44_RS09270	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E5Z44_RS09280	ENOG4105K70	DNA-binding protein
E5Z44_RS09285	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E5Z44_RS09295	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E5Z44_RS09305	ENOG4105HDK	L-asparaginase
E5Z44_RS09315	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
E5Z44_RS09320	ENOG4106BU8	elastin-binding protein ebpS
E5Z44_RS09325	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E5Z44_RS09350	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E5Z44_RS09355	ENOG4105FE9	pseudouridine synthase
E5Z44_RS09360	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E5Z44_RS09365	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
E5Z44_RS09375	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E5Z44_RS09380	ENOG4105I3K	Ferric uptake regulator, Fur family
E5Z44_RS09385	ENOG4108YZ4	nudix hydrolase
E5Z44_RS09390	ENOG4105CPC	Aldo Keto reductase
E5Z44_RS09395	ENOG4108ETT	Dehydrogenase
E5Z44_RS09400	ENOG4105II7	pyrroline-5-carboxylate reductase
E5Z44_RS09410	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
E5Z44_RS09435	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E5Z44_RS09445	ENOG4108RS6	transposase
E5Z44_RS09450	ENOG4108QEG	Membrane
E5Z44_RS09455	ENOG4108Y6J	UPF0403 protein
E5Z44_RS09460	ENOG4105C7S	Dehydrogenase
E5Z44_RS09465	ENOG4105CPP	Dehydrogenase, E1 component
E5Z44_RS09480	ENOG4108IJ2	phosphate acetyltransferase
E5Z44_RS09485	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E5Z44_RS09490	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
E5Z44_RS09510	ENOG4105M7K	Involved in the transcription termination process (By similarity)
E5Z44_RS09515	ENOG4108ZSR	alkaline shock protein
E5Z44_RS09520	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E5Z44_RS09530	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E5Z44_RS09535	ENOG4105DC7	peptidase M24
E5Z44_RS09550	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
E5Z44_RS09555	ENOG4105WZW	rhodanese family
E5Z44_RS09560	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5Z44_RS09565	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5Z44_RS09570	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E5Z44_RS09575	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E5Z44_RS09600	ENOG4106855	Competence protein
E5Z44_RS09615	ENOG4105C5X	domain protein
E5Z44_RS09635	ENOG4107ZXI	Rhomboid family
E5Z44_RS09640	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E5Z44_RS09645	ENOG4105WDJ	50S ribosomal protein L33
E5Z44_RS09650	ENOG4107RF6	penicillin-binding protein
E5Z44_RS09655	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E5Z44_RS09660	ENOG4105N80	Ferric uptake regulator, Fur family
E5Z44_RS09665	ENOG4105FAV	ABC, transporter
E5Z44_RS09670	ENOG4105FDK	ABC transporter
E5Z44_RS09675	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
E5Z44_RS09680	ENOG4105C1J	atp-dependent rna helicase
E5Z44_RS09685	ENOG4105EGD	dinuclear metal center protein, YbgI family
E5Z44_RS09695	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E5Z44_RS09705	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E5Z44_RS09715	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
E5Z44_RS09720	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
E5Z44_RS09725	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E5Z44_RS09730	ENOG4105KG3	cytidine deaminase
E5Z44_RS09735	ENOG4107YR5	Diacylglycerol kinase
E5Z44_RS09740	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E5Z44_RS09745	ENOG4105C9A	Phoh family
E5Z44_RS09755	ENOG4105DI5	UPF0365 protein
E5Z44_RS09760	ENOG4105F7J	membrane-bound serine protease
E5Z44_RS09770	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E5Z44_RS09775	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E5Z44_RS09780	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E5Z44_RS09785	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E5Z44_RS09790	ENOG4105CFG	Acts as a chaperone (By similarity)
E5Z44_RS09795	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5Z44_RS09805	ENOG4105CSA	Coproporphyrinogen iii oxidase
E5Z44_RS09810	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E5Z44_RS09815	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E5Z44_RS09820	ENOG4105TQK	DNA polymerase iii, delta' subunit
E5Z44_RS09825	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E5Z44_RS09830	ENOG4108UK2	deaminase
E5Z44_RS09835	ENOG4105KQC	Competence protein
E5Z44_RS09840	ENOG4105DXX	methyltransferase
E5Z44_RS09845	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
E5Z44_RS09850	ENOG4108WF2	Metal Dependent Phosphohydrolase
E5Z44_RS09855	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E5Z44_RS09860	ENOG410812S	Rna-binding protein
E5Z44_RS09870	ENOG4105CQW	ribosome biogenesis GTPase YqeH
E5Z44_RS09875	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
E5Z44_RS09880	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E5Z44_RS09885	ENOG4105C5A	transporter
E5Z44_RS09895	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E5Z44_RS09900	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E5Z44_RS09910	ENOG4105P4J	Allophanate hydrolase, subunit 1
E5Z44_RS09915	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E5Z44_RS09920	ENOG4105DBI	uridine monophosphokinase
E5Z44_RS09925	ENOG4105CFP	Peptidase U32
E5Z44_RS09930	ENOG4105XYU	peptidase (U32 family)
E5Z44_RS09935	ENOG4108VQJ	O-methyltransferase
E5Z44_RS09945	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E5Z44_RS09950	ENOG4105VBH	UPF0297 protein
E5Z44_RS09955	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E5Z44_RS09960	ENOG4105C7H	Helicase, RecD TraA family
E5Z44_RS09970	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E5Z44_RS09975	ENOG4105C3J	Cysteine desulfurase
E5Z44_RS09980	ENOG4105DEN	Luciferase family
E5Z44_RS09990	ENOG4105D1H	recombination factor protein RarA
E5Z44_RS09995	ENOG4105CUZ	uba thif-type nad fad binding protein
E5Z44_RS10005	ENOG4105C9M	aspartyl-trna synthetase
E5Z44_RS10010	ENOG4105CUT	histidyl-tRNA synthetase
E5Z44_RS10015	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E5Z44_RS10020	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E5Z44_RS10025	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E5Z44_RS10035	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E5Z44_RS10040	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E5Z44_RS10045	ENOG4105VIE	preprotein translocase, subunit YajC
E5Z44_RS10050	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E5Z44_RS10055	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E5Z44_RS10060	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E5Z44_RS10065	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E5Z44_RS10070	ENOG41090I5	UPF0735 ACT domain-containing protein
E5Z44_RS10075	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5Z44_RS10085	ENOG4105X36	(ribosomal) protein
E5Z44_RS10090	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E5Z44_RS10100	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E5Z44_RS10115	ENOG4105W5Q	DNA repair protein (RadC
E5Z44_RS10125	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E5Z44_RS10130	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E5Z44_RS10135	ENOG4108R3E	Dna-3-methyladenine glycosylase i
E5Z44_RS10145	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E5Z44_RS10150	ENOG4105D52	delta-aminolevulinic acid dehydratase
E5Z44_RS10160	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
E5Z44_RS10180	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E5Z44_RS10185	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E5Z44_RS10195	ENOG4105U6W	MutT NUDIX family protein
E5Z44_RS10200	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E5Z44_RS10205	ENOG4105VJV	50s ribosomal protein L35
E5Z44_RS10210	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E5Z44_RS10215	ENOG4108IQI	permease
E5Z44_RS10235	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E5Z44_RS10240	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E5Z44_RS10245	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E5Z44_RS10255	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E5Z44_RS10260	ENOG4105C2M	dna polymerase I
E5Z44_RS10265	ENOG4105BZU	Histidine kinase
E5Z44_RS10270	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
E5Z44_RS10275	ENOG4108HMX	isocitrate dehydrogenase (NADP)
E5Z44_RS10280	ENOG4105BZN	citrate synthase
E5Z44_RS10285	ENOG4105C85	amino acid
E5Z44_RS10290	ENOG4108RS6	transposase
E5Z44_RS10295	ENOG4105CA9	Pyruvate kinase
E5Z44_RS10300	ENOG4105CTQ	phosphohexokinase
E5Z44_RS10305	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E5Z44_RS10310	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E5Z44_RS10315	ENOG4105C6K	Malic enzyme
E5Z44_RS10320	ENOG4105C0B	DNA polymerase III (alpha subunit)
E5Z44_RS10325	ENOG4105SFS	phosphoesterase RecJ domain protein
E5Z44_RS10340	ENOG4105E8R	UPF0173 metal-dependent hydrolase
E5Z44_RS10345	ENOG4105DC7	peptidase M24
E5Z44_RS10350	ENOG4105DCF	alanine dehydrogenase
E5Z44_RS10355	ENOG4107YZX	Universal stress protein
E5Z44_RS10360	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E5Z44_RS10375	ENOG4105EJ9	Membrane
E5Z44_RS10380	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E5Z44_RS10390	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
E5Z44_RS10395	ENOG4108ZGC	gaf domain protein
E5Z44_RS10400	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E5Z44_RS10405	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E5Z44_RS10410	ENOG4108X3M	OsmC Ohr family protein
E5Z44_RS10415	ENOG4105C5R	Aminotransferase
E5Z44_RS10420	ENOG4108JQ1	Dehydrogenase
E5Z44_RS10435	ENOG4105F6E	Acyl-transferase
E5Z44_RS10440	ENOG4105C0H	protease
E5Z44_RS10445	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E5Z44_RS10455	ENOG4105CKU	formyltetrahydrofolate synthetase
E5Z44_RS10465	ENOG4105F1V	Acetoin utilization protein
E5Z44_RS10475	ENOG4105CHR	reductase
E5Z44_RS10485	ENOG4105ETE	Transcriptional regulator (LacI family
E5Z44_RS10490	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E5Z44_RS10500	ENOG4105MQN	general stress protein
E5Z44_RS10505	ENOG4105DFU	Cell wall formation (By similarity)
E5Z44_RS10515	ENOG4108VDD	TRNA binding domain protein
E5Z44_RS10520	ENOG4108NKM	UPF0354 protein
E5Z44_RS10525	ENOG4105SZ6	Thioredoxin
E5Z44_RS10540	ENOG4105C8F	Beta-lactamase domain protein
E5Z44_RS10545	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E5Z44_RS10550	ENOG4108V15	phosphotransferase enzyme family
E5Z44_RS10555	ENOG4105F0I	Aminotransferase
E5Z44_RS10560	ENOG4107QSE	Dipeptidase
E5Z44_RS10580	ENOG4105CBX	hi0933 family
E5Z44_RS10590	ENOG4105C8T	Leucyl-tRNA synthetase
E5Z44_RS10595	ENOG410605W	Major Facilitator
E5Z44_RS10600	ENOG4105N5T	Radical SAM Protein
E5Z44_RS10615	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
E5Z44_RS10625	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E5Z44_RS10630	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E5Z44_RS10635	ENOG4108R6K	riboflavin synthase, subunit alpha
E5Z44_RS10640	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E5Z44_RS10650	ENOG4108FQ0	the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis
E5Z44_RS10675	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E5Z44_RS10690	ENOG4106A8V	Protein CrcB homolog
E5Z44_RS10705	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E5Z44_RS10710	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E5Z44_RS10725	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E5Z44_RS10735	ENOG4105CEY	Amp-dependent synthetase and ligase
E5Z44_RS10785	ENOG4105MJ9	esterase
E5Z44_RS10790	ENOG4105C1Q	protoporphyrinogen oxidase
E5Z44_RS10800	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E5Z44_RS10805	ENOG4105Q24	Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation
E5Z44_RS10820	ENOG4105K59	histidine triad (HIT) protein
E5Z44_RS10860	ENOG4107VRP	DNA repair exonuclease
E5Z44_RS10865	ENOG4105WZB	UPF0342 protein
E5Z44_RS10880	ENOG4105WH1	Two component transcriptional regulator luxr family
E5Z44_RS10885	ENOG4105BZU	Histidine kinase
E5Z44_RS10890	ENOG4108YBP	pseudouridine synthase
E5Z44_RS10895	ENOG4105C9Q	fumarate hydratase class II
E5Z44_RS10905	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E5Z44_RS10915	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
E5Z44_RS10920	ENOG4105CDA	abc transporter atp-binding protein
E5Z44_RS10925	ENOG4105E5Q	amino acid AbC transporter
E5Z44_RS11095	ENOG4105G5W	regulator Fur family
E5Z44_RS11105	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5Z44_RS11110	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E5Z44_RS11115	ENOG4107NBY	Membrane
E5Z44_RS11125	ENOG4105EVI	UPF0374 protein
E5Z44_RS11130	ENOG4105CEN	a g-specific adenine glycosylase
E5Z44_RS11135	ENOG41067AE	Membrane-bound metal-dependent hydrolase
E5Z44_RS11145	ENOG4105EY8	ABC transporter
E5Z44_RS11155	ENOG410902V	Modulates RecA activity (By similarity)
E5Z44_RS11160	ENOG4105BZ4	penicillin-binding protein
E5Z44_RS11165	ENOG4108Z0Z	intracellular protease Pfpi family
E5Z44_RS11180	ENOG4108S4H	thioesterase Superfamily protein
E5Z44_RS11195	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
E5Z44_RS11205	ENOG4107U9T	Pfam:Ribonuclease_BN
E5Z44_RS11215	ENOG4105ENE	Histidine kinase
E5Z44_RS11230	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E5Z44_RS11235	ENOG4108V3A	UPF0421 protein
E5Z44_RS11240	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E5Z44_RS11260	ENOG41090A1	ferritin
E5Z44_RS11270	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E5Z44_RS11285	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E5Z44_RS11290	ENOG4105CBD	Diacylglycerol kinase
E5Z44_RS11295	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E5Z44_RS11300	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E5Z44_RS11325	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E5Z44_RS11330	ENOG4105C4R	Atp-dependent dna helicase
E5Z44_RS11335	ENOG4108RTE	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity)
E5Z44_RS11340	ENOG4105KGF	protein, YerC YecD
E5Z44_RS11345	ENOG4105C83	adenylosuccinate lyase
E5Z44_RS11355	ENOG4108U5N	UPF0316 protein
E5Z44_RS11360	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
E5Z44_RS11365	ENOG4105DAP	Nicotinate phosphoribosyltransferase
E5Z44_RS11375	ENOG4105CQC	Prephenate dehydratase
E5Z44_RS11395	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
E5Z44_RS11400	ENOG4105C26	Dehydrogenase
E5Z44_RS11405	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E5Z44_RS11445	ENOG4105CJ1	ABC, transporter
E5Z44_RS11455	ENOG4105CJ1	ABC, transporter
E5Z44_RS11460	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
E5Z44_RS11470	ENOG4107QSS	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity)
E5Z44_RS11500	ENOG4108TFU	terminase (Small subunit)
E5Z44_RS11570	ENOG4105VTR	Integrase
E5Z44_RS11600	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
E5Z44_RS11605	ENOG410695V	Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity)
E5Z44_RS11620	ENOG4108WCX	response regulator
E5Z44_RS11640	ENOG4105BZU	Histidine kinase
E5Z44_RS11655	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
E5Z44_RS11660	ENOG4105C5H	ABC transporter
E5Z44_RS11670	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E5Z44_RS11675	ENOG410801F	ribosomal-protein-alanine acetyltransferase
E5Z44_RS11680	ENOG41072GX	Peptidase M22 Glycoprotease
E5Z44_RS11685	ENOG4105K8N	protein family UPF0079, ATPase
E5Z44_RS11695	ENOG4105C7K	acetolactate synthase
E5Z44_RS11705	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E5Z44_RS11710	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E5Z44_RS11715	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E5Z44_RS11720	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E5Z44_RS11730	ENOG4105C7B	Threonine dehydratase
E5Z44_RS11780	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
E5Z44_RS11785	ENOG4105WN5	stage II sporulation protein
E5Z44_RS11790	ENOG4107SGM	protein serine threonine phosphatase
E5Z44_RS11795	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
E5Z44_RS11805	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E5Z44_RS11810	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E5Z44_RS11820	ENOG4105CKV	Membrane
E5Z44_RS11830	ENOG4105C1J	atp-dependent rna helicase
E5Z44_RS11835	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
E5Z44_RS11840	ENOG4105CPF	Cell wall formation (By similarity)
E5Z44_RS11860	ENOG4105VPX	protein, conserved in bacteria
E5Z44_RS11865	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
E5Z44_RS11875	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
E5Z44_RS11880	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
E5Z44_RS11885	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
E5Z44_RS11895	ENOG4105JH5	thiaminase II
E5Z44_RS11925	ENOG4105BZ1	(ABC) transporter
E5Z44_RS11935	ENOG4108RS6	transposase
E5Z44_RS11940	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E5Z44_RS11945	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E5Z44_RS11950	ENOG4106778	Protein of unknown function (DUF1146)
E5Z44_RS11960	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E5Z44_RS11965	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E5Z44_RS11980	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
E5Z44_RS11985	ENOG4105WS6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E5Z44_RS11990	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
E5Z44_RS12005	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E5Z44_RS12010	ENOG4108UIC	UPF0340 protein
E5Z44_RS12020	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E5Z44_RS12025	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E5Z44_RS12030	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E5Z44_RS12040	ENOG41082DI	50s ribosomal protein l31
E5Z44_RS12045	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E5Z44_RS12050	ENOG4105C26	Dehydrogenase
E5Z44_RS12060	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E5Z44_RS12065	ENOG4105D2N	Aldolase
E5Z44_RS12075	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E5Z44_RS12080	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
E5Z44_RS12090	ENOG4105HNY	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
E5Z44_RS12110	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
E5Z44_RS12130	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E5Z44_RS12135	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
E5Z44_RS12140	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E5Z44_RS12145	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
E5Z44_RS12150	ENOG4108RMU	ferritin dps family protein
E5Z44_RS12170	ENOG4105DG6	mannose-6-phosphate isomerase
E5Z44_RS12185	ENOG4105PGM	cation diffusion facilitator family transporter