locus-tag	class	description
AL499_RS00010	COG1131	(ABC) transporter
AL499_RS00015	COG4473	ABC transporter
AL499_RS00020	COG2329	Antibiotic biosynthesis monooxygenase
AL499_RS00025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL499_RS00035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL499_RS00040	COG3545	Serine hydrolase
AL499_RS00090	COG0318	PFAM AMP-dependent synthetase and ligase
AL499_RS00100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL499_RS00110	COG1506	peptidase
AL499_RS00115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL499_RS00120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL499_RS00130	COG0656	L-ascorbic acid biosynthetic process
AL499_RS00135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL499_RS00150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL499_RS00175	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL499_RS00175	COG3266	domain, Protein
AL499_RS00175	COG4193	domain, Protein
AL499_RS00185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL499_RS00185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL499_RS00195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL499_RS00195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL499_RS00200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL499_RS00205	COG0506	proline dehydrogenase activity
AL499_RS00210	COG2267	carboxylic ester hydrolase activity
AL499_RS00220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AL499_RS00225	COG1242	4 iron, 4 sulfur cluster binding
AL499_RS00230	COG2814	Major facilitator Superfamily
AL499_RS00235	COG0495	leucyl-tRNA aminoacylation
AL499_RS00245	COG2081	HI0933 family
AL499_RS00250	COG2244	polysaccharide biosynthetic process
AL499_RS00255	COG1187	pseudouridine synthase activity
AL499_RS00265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL499_RS00275	COG0510	thiamine kinase activity
AL499_RS00280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL499_RS00285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL499_RS00290	COG5584	Small secreted protein
AL499_RS00295	COG1363	Peptidase, m42
AL499_RS00300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL499_RS00305	COG4848	Belongs to the UPF0354 family
AL499_RS00310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL499_RS00315	COG1674	ftsk spoiiie
AL499_RS00320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL499_RS00325	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AL499_RS00335	COG1605	Chorismate mutase
AL499_RS00335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL499_RS00340	COG1609	Transcriptional regulator
AL499_RS00355	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL499_RS00360	COG0454	-acetyltransferase
AL499_RS00365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL499_RS00370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL499_RS00380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL499_RS00390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL499_RS00395	COG0204	Acyl-transferase
AL499_RS00400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS00400	COG1263	PTS System
AL499_RS00410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL499_RS00415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL499_RS00420	COG1764	response to oxidative stress
AL499_RS00425	COG0584	glycerophosphoryl diester phosphodiesterase
AL499_RS00430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL499_RS00435	COG1956	GAF domain-containing protein
AL499_RS00440	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL499_RS00445	COG1104	cysteine desulfurase activity
AL499_RS00450	COG0301	tRNA thio-modification
AL499_RS00455	COG0730	response to heat
AL499_RS00460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL499_RS00465	COG0827	DNA restriction-modification system
AL499_RS00470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL499_RS00475	COG0589	response to stress
AL499_RS00480	COG0686	Belongs to the AlaDH PNT family
AL499_RS00485	COG0006	proline dipeptidase activity
AL499_RS00490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL499_RS00500	COG4109	DRTGG domain
AL499_RS00505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL499_RS00510	COG0587	DNA-directed DNA polymerase activity
AL499_RS00515	COG0281	malic enzyme
AL499_RS00520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL499_RS00525	COG0825	malonyl-CoA metabolic process
AL499_RS00530	COG0205	6-phosphofructokinase activity
AL499_RS00535	COG0469	pyruvate kinase activity
AL499_RS00545	COG1113	amino acid transport
AL499_RS00550	COG0372	Belongs to the citrate synthase family
AL499_RS00555	COG0538	isocitrate dehydrogenase activity
AL499_RS00560	COG0745	RESPONSE REGULATOR receiver
AL499_RS00565	COG5002	protein histidine kinase activity
AL499_RS00570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL499_RS00570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL499_RS00575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL499_RS00580	COG0237	dephospho-CoA kinase activity
AL499_RS00585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL499_RS00590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL499_RS00595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL499_RS00600	COG3611	Membrane attachment protein
AL499_RS00605	COG1484	DNA-dependent DNA replication
AL499_RS00615	COG0833	amino acid
AL499_RS00620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL499_RS00625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL499_RS00630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL499_RS00635	COG4112	unkown
AL499_RS00645	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL499_RS00650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL499_RS00665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL499_RS00670	COG0181	hydroxymethylbilane synthase activity
AL499_RS00685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL499_RS00695	COG2818	Glycosylase
AL499_RS00700	COG0525	valine-tRNA ligase activity
AL499_RS00705	COG0285	dihydrofolate synthase activity
AL499_RS00715	COG2003	Belongs to the UPF0758 family
AL499_RS00725	COG1792	Involved in formation and maintenance of cell shape
AL499_RS00735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL499_RS00740	COG2868	ribosomal protein
AL499_RS00750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL499_RS00755	COG4492	Belongs to the UPF0735 family
AL499_RS00760	COG0632	four-way junction helicase activity
AL499_RS00765	COG2255	four-way junction helicase activity
AL499_RS00770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL499_RS00775	COG0343	queuine tRNA-ribosyltransferase activity
AL499_RS00780	COG1862	Preprotein translocase
AL499_RS00785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL499_RS00785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL499_RS00790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL499_RS00790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL499_RS00800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL499_RS00805	COG1490	D-aminoacyl-tRNA deacylase activity
AL499_RS00810	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL499_RS00815	COG0124	histidyl-tRNA synthetase
AL499_RS00820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL499_RS00830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL499_RS00835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL499_RS00840	COG1959	2 iron, 2 sulfur cluster binding
AL499_RS00845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL499_RS00850	COG1104	cysteine desulfurase activity
AL499_RS00855	COG0482	sulfurtransferase activity
AL499_RS00865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL499_RS00870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL499_RS00875	COG4472	Bacterial protein of unknown function (DUF965)
AL499_RS00880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL499_RS00890	COG4122	O-methyltransferase activity
AL499_RS00895	COG0826	peptidase U32
AL499_RS00900	COG0826	peptidase U32
AL499_RS00905	COG0572	uridine kinase
AL499_RS00910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL499_RS00915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL499_RS00920	COG1984	allophanate hydrolase subunit 2
AL499_RS00925	COG0511	ligase activity, forming carbon-carbon bonds
AL499_RS00930	COG0439	Biotin carboxylase
AL499_RS00940	COG1914	H( )-stimulated, divalent metal cation uptake system
AL499_RS00945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL499_RS00950	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AL499_RS00955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL499_RS00965	COG1534	Rna-binding protein
AL499_RS00970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL499_RS00975	COG1713	HD superfamily hydrolase involved in NAD metabolism
AL499_RS00980	COG0799	negative regulation of ribosome biogenesis
AL499_RS00985	COG2226	methyltransferase
AL499_RS00990	COG1596	polysaccharide export
AL499_RS00990	COG1555	photosystem II stabilization
AL499_RS00995	COG2131	deaminase
AL499_RS01000	COG2333	competence protein COMEC
AL499_RS01000	COG0658	competence protein
AL499_RS01005	COG1466	dna polymerase III delta subunit
AL499_RS01010	COG0268	Binds directly to 16S ribosomal RNA
AL499_RS01015	COG0481	GTPase activity
AL499_RS01020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL499_RS01030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL499_RS01035	COG0443	Heat shock 70 kDa protein
AL499_RS01040	COG0484	heat shock protein binding
AL499_RS01045	COG2264	protein methyltransferase activity
AL499_RS01050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL499_RS01055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL499_RS01065	COG1030	water channel activity
AL499_RS01070	COG4864	UPF0365 protein
AL499_RS01080	COG1702	phosphate starvation-inducible protein PhoH
AL499_RS01085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL499_RS01090	COG0295	cytidine deaminase activity
AL499_RS01095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL499_RS01100	COG1381	Involved in DNA repair and RecF pathway recombination
AL499_RS01105	COG0423	glycine-tRNA ligase activity
AL499_RS01110	COG0517	IMP dehydrogenase activity
AL499_RS01115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL499_RS01130	COG2384	SAM-dependent methyltransferase
AL499_RS01140	COG0513	Belongs to the DEAD box helicase family
AL499_RS01145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL499_RS01150	COG1121	(ABC) transporter
AL499_RS01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL499_RS01165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL499_RS01170	COG0768	penicillin binding
AL499_RS01175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL499_RS01180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL499_RS01185	COG0457	Tetratricopeptide repeat
AL499_RS01185	COG0705	Rhomboid family
AL499_RS01190	COG4483	Protein conserved in bacteria
AL499_RS01195	COG1940	carbohydrate kinase activity
AL499_RS01200	COG0011	TIGRFAM Protein of
AL499_RS01205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL499_RS01210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL499_RS01215	COG1459	type II secretion system
AL499_RS01220	COG4537	Required for transformation and DNA binding
AL499_RS01245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL499_RS01250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL499_RS01255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL499_RS01260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL499_RS01265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL499_RS01270	COG0095	Lipoate-protein ligase
AL499_RS01285	COG0006	proline dipeptidase activity
AL499_RS01290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL499_RS01295	COG0511	ligase activity, forming carbon-carbon bonds
AL499_RS01300	COG0439	Biotin carboxylase
AL499_RS01305	COG1302	Protein conserved in bacteria
AL499_RS01310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL499_RS01330	COG1438	arginine binding
AL499_RS01335	COG0497	DNA recombination
AL499_RS01340	COG0280	phosphate acetyltransferase
AL499_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL499_RS01350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL499_RS01355	COG0022	dehydrogenase e1 component
AL499_RS01360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL499_RS01370	COG4129	membrane
AL499_RS01380	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL499_RS01390	COG1609	Transcriptional regulator
AL499_RS01395	COG0366	Alpha amylase catalytic
AL499_RS01405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL499_RS01415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL499_RS01420	COG0300	oxidoreductase activity
AL499_RS01430	COG0667	Aldo Keto reductase
AL499_RS01435	COG0494	nUDIX hydrolase
AL499_RS01440	COG0735	belongs to the Fur family
AL499_RS01445	COG4974	Belongs to the 'phage' integrase family
AL499_RS01455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL499_RS01460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL499_RS01465	COG1187	pseudouridine synthase activity
AL499_RS01470	COG0745	RESPONSE REGULATOR receiver
AL499_RS01485	COG1141	Ferredoxin
AL499_RS01495	COG0514	ATP-dependent DNA helicase (RecQ)
AL499_RS01500	COG1388	LysM domain
AL499_RS01505	COG0492	ferredoxin-NADP+ reductase activity
AL499_RS01525	COG0539	negative regulation of cytoplasmic translation
AL499_RS01535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL499_RS01550	COG2226	methyltransferase
AL499_RS01555	COG0142	geranyltranstransferase activity
AL499_RS01565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL499_RS01570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL499_RS01595	COG2738	Putative neutral zinc metallopeptidase
AL499_RS01600	COG1694	Mazg nucleotide pyrophosphohydrolase
AL499_RS01605	COG0438	transferase activity, transferring glycosyl groups
AL499_RS01610	COG0617	tRNA 3'-terminal CCA addition
AL499_RS01615	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL499_RS01615	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL499_RS01620	COG1199	ATP-dependent helicase activity
AL499_RS01620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL499_RS01625	COG0017	Asparaginyl-tRNA synthetase
AL499_RS01630	COG3935	DnaD domain protein
AL499_RS01635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL499_RS01645	COG4499	WXG100 protein secretion system (Wss), protein YukC
AL499_RS01645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL499_RS01660	COG4474	Belongs to the UPF0398 family
AL499_RS01665	COG3599	regulation of cell shape
AL499_RS01675	COG0116	Belongs to the methyltransferase superfamily
AL499_RS01685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AL499_RS01690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL499_RS01695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL499_RS01700	COG0512	Glutamine amidotransferase of anthranilate synthase
AL499_RS01705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL499_RS01710	COG0134	indole-3-glycerol-phosphate synthase activity
AL499_RS01715	COG0135	phosphoribosylanthranilate isomerase activity
AL499_RS01730	COG2348	transferase activity, transferring amino-acyl groups
AL499_RS01740	COG0561	phosphatase activity
AL499_RS01745	COG4607	ABC-type enterochelin transport system periplasmic component
AL499_RS01755	COG1164	Oligoendopeptidase f
AL499_RS01765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL499_RS01770	COG0581	inorganic phosphate transmembrane transporter activity
AL499_RS01775	COG0573	inorganic phosphate transmembrane transporter activity
AL499_RS01780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL499_RS01785	COG2996	Protein conserved in bacteria
AL499_RS01790	COG0488	(ABC) transporter
AL499_RS01795	COG0527	aspartate kinase activity
AL499_RS01800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL499_RS01805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL499_RS01810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL499_RS01815	COG2171	N-acyltransferase activity
AL499_RS01820	COG1473	amidohydrolase
AL499_RS01845	COG1278	Cold shock
AL499_RS01855	COG1254	Belongs to the acylphosphatase family
AL499_RS01865	COG3853	Toxic anion resistance protein (TelA)
AL499_RS01870	COG1114	Component of the transport system for branched-chain amino acids
AL499_RS01875	COG4548	von Willebrand factor, type A
AL499_RS01880	COG0714	Associated with various cellular activities
AL499_RS01900	COG0567	Dehydrogenase, E1 component
AL499_RS01905	COG5002	protein histidine kinase activity
AL499_RS01910	COG0745	RESPONSE REGULATOR receiver
AL499_RS01915	COG0671	phosphoesterase, PA-phosphatase related
AL499_RS01920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL499_RS01930	COG0793	Belongs to the peptidase S41A family
AL499_RS01935	COG4479	Belongs to the UPF0346 family
AL499_RS01945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL499_RS01975	COG1413	lyase activity
AL499_RS01980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL499_RS01985	COG0328	RNA-DNA hybrid ribonuclease activity
AL499_RS01990	COG1363	Peptidase, m42
AL499_RS02010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS02020	COG3623	hexulose-6-phosphate isomerase
AL499_RS02040	COG0287	Prephenate dehydrogenase
AL499_RS02045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL499_RS02050	COG1942	4-Oxalocrotonate Tautomerase
AL499_RS02080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL499_RS02080	COG0392	lysyltransferase activity
AL499_RS02085	COG0628	permease
AL499_RS02090	COG1115	amino acid carrier protein
AL499_RS02095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL499_RS02100	COG0187	DNA topoisomerase II activity
AL499_RS02105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL499_RS02110	COG4841	protein insertion into membrane
AL499_RS02120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL499_RS02125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL499_RS02130	COG1970	mechanosensitive ion channel activity
AL499_RS02135	COG0419	ATPase involved in DNA repair
AL499_RS02145	COG4846	Membrane protein involved in cytochrome C biogenesis
AL499_RS02150	COG3763	UPF0154 protein
AL499_RS02155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL499_RS02160	COG4224	UPF0291 protein
AL499_RS02170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL499_RS02175	COG2340	Cysteine-rich secretory protein family
AL499_RS02185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL499_RS02200	COG0833	amino acid
AL499_RS02210	COG0561	phosphatase activity
AL499_RS02215	COG0083	homoserine kinase activity
AL499_RS02220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL499_RS02225	COG0460	homoserine dehydrogenase
AL499_RS02245	COG1525	nuclease
AL499_RS02260	COG2197	response regulator
AL499_RS02265	COG4585	Histidine kinase
AL499_RS02265	COG2203	Gaf domain
AL499_RS02275	COG1131	(ABC) transporter
AL499_RS02280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL499_RS02295	COG0789	Transcriptional regulator
AL499_RS02300	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AL499_RS02305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL499_RS02315	COG1923	regulation of RNA biosynthetic process
AL499_RS02320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL499_RS02330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL499_RS02335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL499_RS02340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL499_RS02350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL499_RS02355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL499_RS02370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL499_RS02380	COG4195	phage-related replication protein
AL499_RS02385	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL499_RS02390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL499_RS02390	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL499_RS02395	COG1692	metallophosphoesterase
AL499_RS02405	COG1418	mRNA catabolic process
AL499_RS02410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL499_RS02415	COG1058	Belongs to the CinA family
AL499_RS02415	COG1546	Belongs to the CinA family
AL499_RS02435	COG0300	oxidoreductase activity
AL499_RS02440	COG0612	Peptidase, M16
AL499_RS02445	COG0612	Peptidase, M16
AL499_RS02450	COG2188	Transcriptional regulator
AL499_RS02455	COG1674	ftsk spoiiie
AL499_RS02460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL499_RS02465	COG1185	polyribonucleotide nucleotidyltransferase activity
AL499_RS02475	COG0196	riboflavin kinase activity
AL499_RS02485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL499_RS02490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL499_RS02495	COG1358	cellular component organization or biogenesis
AL499_RS02500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AL499_RS02505	COG0195	Participates in both transcription termination and antitermination
AL499_RS02510	COG0779	Required for maturation of 30S ribosomal subunits
AL499_RS02515	COG2176	DNA-directed DNA polymerase activity
AL499_RS02520	COG0442	prolyl-tRNA aminoacylation
AL499_RS02535	COG4589	Belongs to the CDS family
AL499_RS02540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL499_RS02545	COG0233	cytoplasmic translational termination
AL499_RS02550	COG0528	UMP kinase activity
AL499_RS02555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL499_RS02560	COG0052	Belongs to the universal ribosomal protein uS2 family
AL499_RS02565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL499_RS02570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL499_RS02575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL499_RS02580	COG4974	Belongs to the 'phage' integrase family
AL499_RS02585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL499_RS02590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL499_RS02595	COG0758	DNA mediated transformation
AL499_RS02600	COG2348	transferase activity, transferring amino-acyl groups
AL499_RS02605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL499_RS02610	COG0045	succinate-CoA ligase (ADP-forming) activity
AL499_RS02615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL499_RS02625	COG4485	Bacterial membrane protein, YfhO
AL499_RS02635	COG0335	large ribosomal subunit rRNA binding
AL499_RS02640	COG0336	Belongs to the RNA methyltransferase TrmD family
AL499_RS02645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL499_RS02650	COG0228	four-way junction DNA binding
AL499_RS02665	COG0183	Belongs to the thiolase family
AL499_RS02670	COG0318	PFAM AMP-dependent synthetase and ligase
AL499_RS02680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL499_RS02685	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AL499_RS02690	COG0552	protein localization to endoplasmic reticulum
AL499_RS02695	COG1196	nuclear chromosome segregation
AL499_RS02700	COG0571	ribonuclease III activity
AL499_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL499_RS02720	COG0416	fatty acid biosynthetic process
AL499_RS02725	COG1349	DNA-binding transcription factor activity
AL499_RS02730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL499_RS02735	COG1461	Dihydroxyacetone kinase
AL499_RS02740	COG1302	Protein conserved in bacteria
AL499_RS02745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL499_RS02755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL499_RS02770	COG0631	protein serine/threonine phosphatase activity
AL499_RS02780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL499_RS02780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL499_RS02785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL499_RS02795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL499_RS02800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL499_RS02805	COG1758	RNA polymerase activity
AL499_RS02810	COG0194	GDP metabolic process
AL499_RS02830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL499_RS02835	COG0284	orotidine-5'-phosphate decarboxylase activity
AL499_RS02845	COG0505	Belongs to the CarA family
AL499_RS02855	COG0540	Belongs to the ATCase OTCase family
AL499_RS02860	COG2233	PERMEase
AL499_RS02865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AL499_RS02870	COG0564	pseudouridine synthase activity
AL499_RS02875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL499_RS02885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL499_RS02890	COG3599	regulation of cell shape
AL499_RS02895	COG2302	S4 RNA-binding domain
AL499_RS02900	COG0762	integral membrane protein
AL499_RS02905	COG1799	cell septum assembly
AL499_RS02910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL499_RS02915	COG1496	oxidoreductase activity
AL499_RS02920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL499_RS02925	COG0849	cell division
AL499_RS02930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL499_RS02935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL499_RS02940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL499_RS02945	COG0768	penicillin binding
AL499_RS02950	COG4839	cell division protein FtsL
AL499_RS02955	COG0275	rRNA processing
AL499_RS02965	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL499_RS02970	COG0454	-acetyltransferase
AL499_RS02980	COG1011	Hydrolase
AL499_RS02990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL499_RS02995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL499_RS03000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL499_RS03005	COG1053	succinate dehydrogenase
AL499_RS03010	COG2009	succinate dehydrogenase
AL499_RS03015	COG0322	excinuclease ABC activity
AL499_RS03020	COG3118	belongs to the thioredoxin family
AL499_RS03025	COG1193	negative regulation of DNA recombination
AL499_RS03030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL499_RS03030	COG1796	DNA polymerase
AL499_RS03040	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL499_RS03045	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL499_RS03055	COG0072	phenylalanine-tRNA ligase activity
AL499_RS03055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL499_RS03060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL499_RS03065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL499_RS03070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL499_RS03080	COG1323	Belongs to the UPF0348 family
AL499_RS03085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL499_RS03090	COG0742	ribosomal rna small subunit methyltransferase
AL499_RS03110	COG3679	Belongs to the UPF0342 family
AL499_RS03125	COG0109	protoheme IX farnesyltransferase activity
AL499_RS03130	COG1612	heme a metabolic process
AL499_RS03140	COG0772	Belongs to the SEDS family
AL499_RS03145	COG4838	Belongs to the UPF0358 family
AL499_RS03150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL499_RS03160	COG1217	gtp-binding protein TYPA
AL499_RS03170	COG0483	inositol monophosphate 1-phosphatase activity
AL499_RS03175	COG4493	Belongs to the UPF0637 family
AL499_RS03195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL499_RS03200	COG1177	transmembrane transport
AL499_RS03220	COG4476	Belongs to the UPF0223 family
AL499_RS03235	COG0022	dehydrogenase e1 component
AL499_RS03250	COG0242	peptide deformylase activity
AL499_RS03255	COG5503	Protein of unknown function (DUF1447)
AL499_RS03260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL499_RS03270	COG0569	domain protein
AL499_RS03285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL499_RS03300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL499_RS03315	COG4172	Belongs to the ABC transporter superfamily
AL499_RS03320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL499_RS03325	COG0151	Belongs to the GarS family
AL499_RS03330	COG0138	bifunctional purine biosynthesis protein purh
AL499_RS03340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL499_RS03350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL499_RS03355	COG0047	phosphoribosylformylglycinamidine synthase activity
AL499_RS03360	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL499_RS03365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL499_RS03370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL499_RS03375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL499_RS03380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL499_RS03385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL499_RS03385	COG1017	nitric oxide dioxygenase activity
AL499_RS03395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL499_RS03405	COG1845	cytochrome c oxidase, subunit III
AL499_RS03410	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL499_RS03420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL499_RS03425	COG1316	TRANSCRIPTIONal
AL499_RS03450	COG3594	Acyltransferase
AL499_RS03455	COG0436	Aminotransferase
AL499_RS03460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL499_RS03465	COG0596	Alpha beta hydrolase
AL499_RS03470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL499_RS03475	COG1169	isochorismate synthase
AL499_RS03480	COG1575	Belongs to the MenA family. Type 1 subfamily
AL499_RS03555	COG4873	Protein conserved in bacteria
AL499_RS03565	COG0737	Belongs to the 5'-nucleotidase family
AL499_RS03570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL499_RS03575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL499_RS03580	COG0861	Integral membrane protein TerC family
AL499_RS03595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL499_RS03600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL499_RS03605	COG2814	Major facilitator Superfamily
AL499_RS03610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL499_RS03615	COG0789	Transcriptional regulator
AL499_RS03620	COG4221	oxidoreductase activity
AL499_RS03630	COG0628	permease
AL499_RS03640	COG0569	domain protein
AL499_RS03640	COG0475	glutathione-regulated potassium exporter activity
AL499_RS03645	COG2239	Acts as a magnesium transporter
AL499_RS03650	COG0564	pseudouridine synthase activity
AL499_RS03660	COG2357	RelA SpoT domain protein
AL499_RS03675	COG2346	COG2346, Truncated hemoglobins
AL499_RS03680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL499_RS03685	COG1164	Oligoendopeptidase f
AL499_RS03700	COG1393	Belongs to the ArsC family
AL499_RS03705	COG0180	Tryptophanyl-tRNA synthetase
AL499_RS03710	COG2226	methyltransferase
AL499_RS03715	COG4166	transmembrane transport
AL499_RS03720	COG4608	Belongs to the ABC transporter superfamily
AL499_RS03725	COG0444	Belongs to the ABC transporter superfamily
AL499_RS03730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL499_RS03735	COG0601	transmembrane transport
AL499_RS03750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL499_RS03760	COG0542	response to heat
AL499_RS03770	COG0561	phosphatase activity
AL499_RS03775	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL499_RS03790	COG1074	ATP-dependent DNA helicase activity
AL499_RS03810	COG0398	Pfam SNARE associated Golgi protein
AL499_RS03815	COG0166	Belongs to the GPI family
AL499_RS03820	COG0137	argininosuccinate synthase activity
AL499_RS03850	COG1902	pentaerythritol trinitrate reductase activity
AL499_RS03855	COG1098	S1 RNA binding domain
AL499_RS03860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL499_RS03870	COG2111	Na H antiporter
AL499_RS03870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL499_RS03875	COG2111	Na H antiporter
AL499_RS03880	COG1006	Multisubunit Na H antiporter MnhC subunit
AL499_RS03885	COG0651	ATP synthesis coupled electron transport
AL499_RS03890	COG1863	multisubunit Na H antiporter MnhE subunit
AL499_RS03895	COG2212	antiporter activity
AL499_RS03900	COG1320	monovalent cation:proton antiporter activity
AL499_RS03910	COG2050	protein possibly involved in aromatic compounds catabolism
AL499_RS03915	COG2056	Na+-H+ antiporter family
AL499_RS03920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL499_RS03925	COG1252	NADH dehydrogenase
AL499_RS03935	COG1132	(ABC) transporter
AL499_RS03945	COG1129	ABC transporter
AL499_RS03975	COG3433	isochorismatase activity
AL499_RS03975	COG2226	methyltransferase
AL499_RS03975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL499_RS03980	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL499_RS03995	COG0316	Belongs to the HesB IscA family
AL499_RS04000	COG4844	belongs to the
AL499_RS04005	COG1252	NADH dehydrogenase
AL499_RS04010	COG4837	Protein of unknown function (DUF1462)
AL499_RS04015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL499_RS04020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AL499_RS04025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL499_RS04030	COG1696	Membrane protein involved in D-alanine export
AL499_RS04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL499_RS04045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL499_RS04050	COG0647	UMP catabolic process
AL499_RS04055	COG2445	Protein of unknown function DUF86
AL499_RS04065	COG4470	Protein conserved in bacteria
AL499_RS04070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL499_RS04075	COG0737	Belongs to the 5'-nucleotidase family
AL499_RS04080	COG0730	response to heat
AL499_RS04085	COG1801	Protein of unknown function DUF72
AL499_RS04090	COG2070	2-Nitropropane dioxygenase
AL499_RS04095	COG1253	flavin adenine dinucleotide binding
AL499_RS04250	COG3942	CHAP domain
AL499_RS04250	COG1388	LysM domain
AL499_RS04270	COG0719	Fe-S assembly protein
AL499_RS04275	COG0822	iron-sulfur transferase activity
AL499_RS04285	COG0719	Fe-S assembly protein
AL499_RS04290	COG0396	ATPase activity
AL499_RS04310	COG1464	Belongs to the NlpA lipoprotein family
AL499_RS04315	COG2011	ABC-type metal ion transport system permease component
AL499_RS04320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL499_RS04330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL499_RS04335	COG0509	glycine decarboxylation via glycine cleavage system
AL499_RS04340	COG1393	Belongs to the ArsC family
AL499_RS04345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL499_RS04355	COG0710	3-dehydroquinate dehydratase activity
AL499_RS04360	COG1764	response to oxidative stress
AL499_RS04370	COG0588	phosphoglycerate mutase activity
AL499_RS04395	COG4195	phage-related replication protein
AL499_RS04410	COG2259	Doxx family
AL499_RS04415	COG0346	lactoylglutathione lyase activity
AL499_RS04425	COG1611	Belongs to the LOG family
AL499_RS04510	COG0557	exoribonuclease II activity
AL499_RS04515	COG1647	Serine aminopeptidase, S33
AL499_RS04520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL499_RS04530	COG0148	phosphopyruvate hydratase activity
AL499_RS04535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL499_RS04540	COG0149	triose-phosphate isomerase activity
AL499_RS04545	COG0126	phosphoglycerate kinase activity
AL499_RS04565	COG1090	epimerase
AL499_RS04570	COG0740	serine-type endopeptidase activity
AL499_RS04580	COG1481	regulation of sporulation
AL499_RS04585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL499_RS04590	COG1660	Displays ATPase and GTPase activities
AL499_RS04595	COG0492	ferredoxin-NADP+ reductase activity
AL499_RS04610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL499_RS04615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL499_RS04620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL499_RS04640	COG3942	CHAP domain
AL499_RS04640	COG1388	LysM domain
AL499_RS04645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL499_RS04650	COG0653	protein targeting
AL499_RS04660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL499_RS04665	COG1040	competence protein
AL499_RS04670	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AL499_RS04680	COG1739	Uncharacterized protein family UPF0029
AL499_RS04685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL499_RS04690	COG2199	diguanylate cyclase activity
AL499_RS04705	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL499_RS04715	COG1929	Belongs to the glycerate kinase type-1 family
AL499_RS04735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL499_RS04745	COG4607	ABC-type enterochelin transport system periplasmic component
AL499_RS04750	COG4604	ABC transporter, ATP-binding protein
AL499_RS04755	COG4605	iron ion homeostasis
AL499_RS04760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS04765	COG4607	ABC-type enterochelin transport system periplasmic component
AL499_RS04770	COG4604	ABC transporter, ATP-binding protein
AL499_RS04775	COG4605	iron ion homeostasis
AL499_RS04780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS04785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL499_RS04790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL499_RS04795	COG1780	Probably involved in ribonucleotide reductase function
AL499_RS04805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL499_RS04810	COG3104	oligopeptide transport
AL499_RS04815	COG1597	lipid kinase activity
AL499_RS04825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL499_RS04830	COG3104	oligopeptide transport
AL499_RS04835	COG1174	glycine betaine transport
AL499_RS04845	COG0514	ATP-dependent DNA helicase (RecQ)
AL499_RS04850	COG0488	(ABC) transporter
AL499_RS04865	COG1368	sulfuric ester hydrolase activity
AL499_RS04875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL499_RS04885	COG0512	Glutamine amidotransferase of anthranilate synthase
AL499_RS04885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL499_RS04890	COG0512	Glutamine amidotransferase of anthranilate synthase
AL499_RS04890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL499_RS04900	COG0720	synthase
AL499_RS04915	COG0463	Glycosyl transferase, family 2
AL499_RS04920	COG0656	L-ascorbic acid biosynthetic process
AL499_RS04925	COG1253	flavin adenine dinucleotide binding
AL499_RS04930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL499_RS04930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS04930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL499_RS04935	COG1105	Belongs to the carbohydrate kinase PfkB family
AL499_RS04940	COG1349	DNA-binding transcription factor activity
AL499_RS04945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL499_RS04970	COG0415	Belongs to the DNA photolyase family
AL499_RS04975	COG0471	metal ion transport
AL499_RS04980	COG0039	L-malate dehydrogenase activity
AL499_RS04990	COG0523	cobalamin synthesis protein
AL499_RS05000	COG1968	undecaprenyl-diphosphatase activity
AL499_RS05010	COG1671	Belongs to the UPF0178 family
AL499_RS05015	COG1611	Belongs to the LOG family
AL499_RS05040	COG2839	Protein conserved in bacteria
AL499_RS05045	COG2814	Major facilitator Superfamily
AL499_RS05050	COG0583	DNA-binding transcription factor activity
AL499_RS05070	COG0217	transcriptional regulatory protein
AL499_RS05090	COG3942	CHAP domain
AL499_RS05090	COG1388	LysM domain
AL499_RS05095	COG0306	phosphate transporter
AL499_RS05100	COG1392	Phosphate transport regulator
AL499_RS05105	COG0577	efflux transmembrane transporter activity
AL499_RS05110	COG1136	(ABC) transporter
AL499_RS05115	COG2205	protein histidine kinase activity
AL499_RS05120	COG0745	RESPONSE REGULATOR receiver
AL499_RS05125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL499_RS05135	COG0657	acetylesterase activity
AL499_RS05140	COG3949	Membrane
AL499_RS05150	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AL499_RS05155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS05160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS05165	COG1120	ATPase activity
AL499_RS05170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL499_RS05180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL499_RS05190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS05190	COG0463	Glycosyl transferase, family 2
AL499_RS05195	COG0438	transferase activity, transferring glycosyl groups
AL499_RS05200	COG1132	(ABC) transporter
AL499_RS05205	COG1686	Belongs to the peptidase S11 family
AL499_RS05210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL499_RS05215	COG1215	transferase activity, transferring glycosyl groups
AL499_RS05220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS05230	COG1682	transport, permease protein
AL499_RS05235	COG1134	teichoic acid transport
AL499_RS05250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL499_RS05260	COG1321	iron dependent repressor
AL499_RS05265	COG1121	(ABC) transporter
AL499_RS05270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL499_RS05275	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL499_RS05285	COG1320	monovalent cation:proton antiporter activity
AL499_RS05290	COG2212	antiporter activity
AL499_RS05295	COG1863	multisubunit Na H antiporter MnhE subunit
AL499_RS05300	COG0651	ATP synthesis coupled electron transport
AL499_RS05305	COG1006	Multisubunit Na H antiporter MnhC subunit
AL499_RS05310	COG2111	Na H antiporter
AL499_RS05315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL499_RS05315	COG2111	Na H antiporter
AL499_RS05320	COG4974	Belongs to the 'phage' integrase family
AL499_RS05350	COG0596	Alpha beta hydrolase
AL499_RS05375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS05380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL499_RS05400	COG0018	arginyl-trna synthetase
AL499_RS05420	COG1064	alcohol dehydrogenase
AL499_RS05430	COG1078	dGTPase activity
AL499_RS05440	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL499_RS05445	COG0667	Aldo Keto reductase
AL499_RS05455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL499_RS05460	COG4844	belongs to the
AL499_RS05480	COG0095	Lipoate-protein ligase
AL499_RS05490	COG3253	May function as heme-dependent peroxidase
AL499_RS05515	COG0531	amino acid
AL499_RS05520	COG2363	Small membrane protein
AL499_RS05530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL499_RS05560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL499_RS05565	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL499_RS05575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL499_RS05585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS05610	COG0561	phosphatase activity
AL499_RS05620	COG1428	Deoxynucleoside kinase
AL499_RS05625	COG1428	Deoxynucleoside kinase
AL499_RS05645	COG0531	amino acid
AL499_RS05650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL499_RS05660	COG1279	arginine transmembrane transporter activity
AL499_RS05685	COG1473	amidohydrolase
AL499_RS05690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL499_RS05705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL499_RS05715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL499_RS05720	COG0085	RNA polymerase activity
AL499_RS05725	COG2813	Specifically methylates the guanine in position
AL499_RS05730	COG0222	ribosome binding
AL499_RS05735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL499_RS05740	COG0081	regulation of translation
AL499_RS05750	COG0250	Participates in transcription elongation, termination and antitermination
AL499_RS05755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL499_RS05765	COG3688	RNA-binding protein containing a PIN domain
AL499_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL499_RS05775	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AL499_RS05780	COG0215	cysteine-tRNA ligase activity
AL499_RS05785	COG1045	serine acetyltransferase
AL499_RS05790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL499_RS05795	COG4956	integral membrane protein (PIN domain superfamily)
AL499_RS05800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL499_RS05805	COG0542	response to heat
AL499_RS05810	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AL499_RS05815	COG3880	PFAM UvrB UvrC protein
AL499_RS05820	COG4463	regulation of RNA biosynthetic process
AL499_RS05825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL499_RS05830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL499_RS05835	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AL499_RS05840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL499_RS05925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL499_RS05930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL499_RS05935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL499_RS05945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL499_RS05955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL499_RS05970	COG1098	S1 RNA binding domain
AL499_RS05980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL499_RS05985	COG3956	TIGRFAM MazG family protein
AL499_RS05990	COG2244	polysaccharide biosynthetic process
AL499_RS05995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL499_RS06000	COG0193	aminoacyl-tRNA hydrolase activity
AL499_RS06010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL499_RS06015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL499_RS06025	COG0251	oxidation-reduction process
AL499_RS06030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL499_RS06035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL499_RS06040	COG4466	Protein conserved in bacteria
AL499_RS06045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL499_RS06050	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL499_RS06055	COG0084	hydrolase, TatD family'
AL499_RS06060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL499_RS06060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL499_RS06065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL499_RS06075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL499_RS06085	COG1774	PSP1 C-terminal conserved region
AL499_RS06090	COG0470	DNA polymerase III
AL499_RS06095	COG3870	Protein conserved in bacteria
AL499_RS06100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL499_RS06105	COG1982	Orn Lys Arg decarboxylase major
AL499_RS06140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL499_RS06150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL499_RS06165	COG2188	Transcriptional regulator
AL499_RS06170	COG0366	Alpha amylase catalytic
AL499_RS06175	COG1263	PTS System
AL499_RS06175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS06185	COG0493	'glutamate synthase
AL499_RS06190	COG0070	glutamate synthase
AL499_RS06190	COG0069	glutamate synthase activity
AL499_RS06190	COG0067	glutamate synthase
AL499_RS06195	COG0583	DNA-binding transcription factor activity
AL499_RS06225	COG1464	Belongs to the NlpA lipoprotein family
AL499_RS06230	COG2011	ABC-type metal ion transport system permease component
AL499_RS06235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL499_RS06240	COG1132	(ABC) transporter
AL499_RS06245	COG1132	(ABC) transporter
AL499_RS06245	COG2375	cellular response to nickel ion
AL499_RS06250	COG0626	cystathionine gamma-synthase activity
AL499_RS06255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL499_RS06265	COG0733	neurotransmitter:sodium symporter activity
AL499_RS06285	COG5609	conserved protein (DUF2294)
AL499_RS06290	COG3002	Belongs to the UPF0753 family
AL499_RS06295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL499_RS06305	COG0523	cobalamin synthesis protein
AL499_RS06325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL499_RS06325	COG0519	Catalyzes the synthesis of GMP from XMP
AL499_RS06330	COG0517	IMP dehydrogenase activity
AL499_RS06330	COG0516	GMP reductase activity
AL499_RS06335	COG2233	PERMEase
AL499_RS06340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL499_RS06360	COG1823	symporter activity
AL499_RS06365	COG0778	Nitroreductase
AL499_RS06375	COG0450	alkyl hydroperoxide reductase
AL499_RS06380	COG3634	alkyl hydroperoxide reductase activity
AL499_RS06395	COG0588	phosphoglycerate mutase activity
AL499_RS06435	COG3728	DNA packaging
AL499_RS06435	COG5484	DNA packaging
AL499_RS06505	COG0582	viral genome integration into host DNA
AL499_RS06510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL499_RS06520	COG0360	Binds together with S18 to 16S ribosomal RNA
AL499_RS06535	COG0012	GTP binding
AL499_RS06540	COG4481	Protein conserved in bacteria
AL499_RS06545	COG0668	transmembrane transport
AL499_RS06550	COG1475	DNA binding
AL499_RS06555	COG0626	cystathionine gamma-synthase activity
AL499_RS06560	COG0626	cystathionine gamma-synthase activity
AL499_RS06565	COG0646	methionine synthase
AL499_RS06565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL499_RS06570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL499_RS06595	COG0577	efflux transmembrane transporter activity
AL499_RS06600	COG1136	(ABC) transporter
AL499_RS06620	COG2205	protein histidine kinase activity
AL499_RS06635	COG0745	RESPONSE REGULATOR receiver
AL499_RS06660	COG3878	Protein conserved in bacteria
AL499_RS06665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL499_RS06670	COG2271	Major facilitator Superfamily
AL499_RS06685	COG1136	(ABC) transporter
AL499_RS06690	COG0577	efflux transmembrane transporter activity
AL499_RS06700	COG1396	sequence-specific DNA binding
AL499_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS06725	COG1063	alcohol dehydrogenase
AL499_RS06745	COG1475	DNA binding
AL499_RS06755	COG0445	tRNA wobble uridine modification
AL499_RS06760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL499_RS06765	COG0594	ribonuclease P activity
AL499_RS06775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL499_RS06780	COG0592	DNA-directed DNA polymerase activity
AL499_RS06785	COG2501	S4 domain
AL499_RS06790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL499_RS06795	COG0187	DNA topoisomerase II activity
AL499_RS06800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL499_RS06805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL499_RS06815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AL499_RS06825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL499_RS06835	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AL499_RS06840	COG0359	binds to the 23S rRNA
AL499_RS06845	COG0305	Participates in initiation and elongation during chromosome replication
AL499_RS06850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL499_RS06865	COG0745	RESPONSE REGULATOR receiver
AL499_RS06870	COG5002	protein histidine kinase activity
AL499_RS06875	COG4863	YycH protein
AL499_RS06910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL499_RS06915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL499_RS06925	COG1522	sequence-specific DNA binding
AL499_RS06945	COG1073	alpha beta
AL499_RS06965	COG1129	ABC transporter
AL499_RS07000	COG5002	protein histidine kinase activity
AL499_RS07005	COG0745	RESPONSE REGULATOR receiver
AL499_RS07020	COG1131	(ABC) transporter
AL499_RS07080	COG2188	Transcriptional regulator
AL499_RS07085	COG2222	sugar isomerase
AL499_RS07090	COG3684	Belongs to the aldolase LacD family
AL499_RS07095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS07100	COG3715	PTS system
AL499_RS07105	COG3716	PTS system mannose fructose sorbose family IID component
AL499_RS07120	COG0745	RESPONSE REGULATOR receiver
AL499_RS07125	COG2205	protein histidine kinase activity
AL499_RS07135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL499_RS07140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL499_RS07165	COG1129	ABC transporter
AL499_RS07200	COG4509	Sortase family
AL499_RS07210	COG3942	CHAP domain
AL499_RS07210	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL499_RS07215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS07220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS07225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL499_RS07230	COG2808	Putative FMN-binding domain
AL499_RS07240	COG1846	Transcriptional regulator
AL499_RS07255	COG3842	ATPase activity
AL499_RS07260	COG4209	transmembrane transport
AL499_RS07270	COG0395	ABC-type sugar transport system, permease component
AL499_RS07280	COG0534	Mate efflux family protein
AL499_RS07285	COG1349	DNA-binding transcription factor activity
AL499_RS07295	COG5002	protein histidine kinase activity
AL499_RS07330	COG0583	DNA-binding transcription factor activity
AL499_RS07335	COG3842	ATPase activity
AL499_RS07340	COG1840	ABC-type Fe3 transport system, periplasmic component
AL499_RS07345	COG1177	transmembrane transport
AL499_RS07350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL499_RS07355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL499_RS07365	COG1114	Component of the transport system for branched-chain amino acids
AL499_RS07375	COG0464	growth
AL499_RS07380	COG0561	phosphatase activity
AL499_RS07385	COG2814	Major facilitator Superfamily
AL499_RS07400	COG0601	transmembrane transport
AL499_RS07410	COG0444	Belongs to the ABC transporter superfamily
AL499_RS07415	COG1124	(ABC) transporter
AL499_RS07430	COG0693	protein deglycase activity
AL499_RS07435	COG0531	amino acid
AL499_RS07445	COG0505	Belongs to the CarA family
AL499_RS07450	COG0657	acetylesterase activity
AL499_RS07490	COG1033	growth of symbiont in host cell
AL499_RS07490	COG2409	Drug exporters of the RND superfamily
AL499_RS07510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL499_RS07525	COG1131	(ABC) transporter
AL499_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS07545	COG1278	Cold shock
AL499_RS07560	COG2311	Membrane
AL499_RS07565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AL499_RS07575	COG1233	COG1233 Phytoene dehydrogenase and related
AL499_RS07595	COG2814	Major facilitator Superfamily
AL499_RS07610	COG1131	(ABC) transporter
AL499_RS07635	COG2264	protein methyltransferase activity
AL499_RS07640	COG0747	negative chemotaxis
AL499_RS07645	COG0601	transmembrane transport
AL499_RS07655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL499_RS07660	COG1124	(ABC) transporter
AL499_RS07665	COG3961	Belongs to the TPP enzyme family
AL499_RS07680	COG1131	(ABC) transporter
AL499_RS07690	COG2353	YceI-like domain
AL499_RS07695	COG1288	antiporter activity
AL499_RS07705	COG2814	Major facilitator Superfamily
AL499_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS07735	COG1263	PTS System
AL499_RS07735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS07735	COG2190	(PTS) system
AL499_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS07765	COG1053	succinate dehydrogenase
AL499_RS07765	COG3976	FMN-binding domain protein
AL499_RS07765	COG0431	NADPH-dependent FMN reductase
AL499_RS07780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL499_RS07790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL499_RS07795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL499_RS07800	COG0022	dehydrogenase e1 component
AL499_RS07810	COG1695	Transcriptional regulator
AL499_RS07835	COG3711	transcriptional antiterminator
AL499_RS07835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS07840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL499_RS07840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL499_RS07840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS07845	COG1482	cell wall glycoprotein biosynthetic process
AL499_RS07850	COG2124	cytochrome p450
AL499_RS07860	COG1846	Transcriptional regulator
AL499_RS07865	COG2814	Major facilitator Superfamily
AL499_RS07890	COG0706	membrane insertase activity
AL499_RS07900	COG0531	amino acid
AL499_RS07955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL499_RS07975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL499_RS07985	COG0363	glucosamine-6-phosphate deaminase activity
AL499_RS07990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL499_RS08005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL499_RS08010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL499_RS08015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL499_RS08050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL499_RS08070	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL499_RS08075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS08075	COG3711	transcriptional antiterminator
AL499_RS08080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL499_RS08095	COG1054	Belongs to the UPF0176 family
AL499_RS08100	COG3386	PFAM SMP-30 Gluconolaconase
AL499_RS08115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL499_RS08125	COG1122	ATPase activity
AL499_RS08135	COG1476	TRANSCRIPTIONal
AL499_RS08165	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL499_RS08165	COG3942	CHAP domain
AL499_RS08190	COG4974	Belongs to the 'phage' integrase family
AL499_RS08220	COG3682	Transcriptional regulator
AL499_RS08225	COG2235	arginine
AL499_RS08235	COG2843	Capsule synthesis protein
AL499_RS08240	COG4195	phage-related replication protein
AL499_RS08245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL499_RS08280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL499_RS08315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL499_RS08320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL499_RS08325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL499_RS08330	COG1785	Belongs to the alkaline phosphatase family
AL499_RS08345	COG2205	protein histidine kinase activity
AL499_RS08350	COG1136	(ABC) transporter
AL499_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS08385	COG3266	domain, Protein
AL499_RS08385	COG4932	domain protein
AL499_RS08385	COG4932	domain protein
AL499_RS08385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL499_RS08385	COG3266	domain, Protein
AL499_RS08385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL499_RS08395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL499_RS08400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL499_RS08415	COG0730	response to heat
AL499_RS08420	COG2046	Belongs to the sulfate adenylyltransferase family
AL499_RS08425	COG0529	Catalyzes the synthesis of activated sulfate
AL499_RS08440	COG1328	CTP reductase activity
AL499_RS08445	COG0602	queuosine metabolic process
AL499_RS08450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL499_RS08460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL499_RS08465	COG1510	regulation of RNA biosynthetic process
AL499_RS08470	COG1012	belongs to the aldehyde dehydrogenase family
AL499_RS08475	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL499_RS08480	COG1473	amidohydrolase
AL499_RS08495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL499_RS08500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL499_RS08500	COG0574	Belongs to the PEP-utilizing enzyme family
AL499_RS08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL499_RS08515	COG2188	Transcriptional regulator
AL499_RS08520	COG2190	(PTS) system
AL499_RS08520	COG1263	PTS System
AL499_RS08520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS08525	COG2723	6-phospho-beta-galactosidase activity
AL499_RS08535	COG0583	DNA-binding transcription factor activity
AL499_RS08550	COG3588	fructose-bisphosphate aldolase
AL499_RS08565	COG1464	Belongs to the NlpA lipoprotein family
AL499_RS08575	COG0463	Glycosyl transferase, family 2
AL499_RS08585	COG1215	transferase activity, transferring glycosyl groups
AL499_RS08585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS08595	COG0531	amino acid
AL499_RS08600	COG0583	DNA-binding transcription factor activity
AL499_RS08605	COG0028	Belongs to the TPP enzyme family
AL499_RS08610	COG3527	Alpha-acetolactate decarboxylase
AL499_RS08615	COG1620	l-lactate permease
AL499_RS08635	COG0167	dihydroorotate dehydrogenase activity
AL499_RS08640	COG3001	Fructosamine kinase
AL499_RS08645	COG0596	Alpha beta hydrolase
AL499_RS08695	COG2814	Major facilitator Superfamily
AL499_RS08705	COG1113	amino acid transport
AL499_RS08720	COG3189	MarR family transcriptional regulator
AL499_RS08740	COG0436	Aminotransferase
AL499_RS08750	COG2608	mercury ion transmembrane transporter activity
AL499_RS08755	COG2217	Heavy metal translocating P-type atpase
AL499_RS08765	COG0110	maltose O-acetyltransferase activity
AL499_RS08770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS08775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL499_RS08780	COG1012	belongs to the aldehyde dehydrogenase family
AL499_RS08790	COG2409	Drug exporters of the RND superfamily
AL499_RS08800	COG0598	Magnesium transport protein CorA
AL499_RS08805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL499_RS08830	COG1131	(ABC) transporter
AL499_RS08840	COG3425	synthase
AL499_RS08855	COG3942	CHAP domain
AL499_RS08855	COG1388	LysM domain
AL499_RS08865	COG0583	DNA-binding transcription factor activity
AL499_RS08870	COG1380	Effector of murein hydrolase LrgA
AL499_RS08875	COG1346	cytolysis
AL499_RS08880	COG0028	Belongs to the TPP enzyme family
AL499_RS08895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL499_RS08900	COG0039	L-malate dehydrogenase activity
AL499_RS08905	COG0657	acetylesterase activity
AL499_RS08915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL499_RS08935	COG1070	Carbohydrate kinase
AL499_RS08945	COG1760	l-serine dehydratase
AL499_RS08950	COG1760	l-serine dehydratase
AL499_RS08960	COG3764	Sortase (surface protein transpeptidase)
AL499_RS08970	COG0561	phosphatase activity
AL499_RS08975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL499_RS08980	COG0778	Nitroreductase
AL499_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
AL499_RS08995	COG2514	catechol 2,3-dioxygenase activity
AL499_RS09000	COG2388	GCN5-related N-acetyl-transferase
AL499_RS09015	COG1846	Transcriptional regulator
AL499_RS09020	COG0346	lactoylglutathione lyase activity
AL499_RS09025	COG0346	lactoylglutathione lyase activity
AL499_RS09030	COG0400	carboxylic ester hydrolase activity
AL499_RS09035	COG3949	Membrane
AL499_RS09045	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AL499_RS09050	COG0586	Pfam SNARE associated Golgi protein
AL499_RS09060	COG2022	thiamine diphosphate biosynthetic process
AL499_RS09080	COG2271	Major facilitator Superfamily
AL499_RS09095	COG4876	unkown
AL499_RS09100	COG2357	RelA SpoT domain protein
AL499_RS09115	COG1802	Transcriptional regulator
AL499_RS09120	COG1070	Carbohydrate kinase
AL499_RS09125	COG2610	gluconate transmembrane transporter activity
AL499_RS09130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL499_RS09140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL499_RS09145	COG0438	transferase activity, transferring glycosyl groups
AL499_RS09150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL499_RS09165	COG4221	oxidoreductase activity
AL499_RS09170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL499_RS09175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL499_RS09180	COG0248	Ppx GppA phosphatase
AL499_RS09185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL499_RS09190	COG1363	Peptidase, m42
AL499_RS09210	COG3639	organic phosphonate transmembrane transporter activity
AL499_RS09215	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL499_RS09230	COG0737	Belongs to the 5'-nucleotidase family
AL499_RS09235	COG0069	glutamate synthase activity
AL499_RS09250	COG4619	ABC transporter
AL499_RS09255	COG0390	transport system, permease component
AL499_RS09260	COG2205	protein histidine kinase activity
AL499_RS09265	COG0745	RESPONSE REGULATOR receiver
AL499_RS09275	COG2814	Major facilitator Superfamily
AL499_RS09280	COG2272	Belongs to the type-B carboxylesterase lipase family
AL499_RS09285	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AL499_RS09290	COG1063	alcohol dehydrogenase
AL499_RS09310	COG1174	glycine betaine transport
AL499_RS09340	COG1346	cytolysis
AL499_RS09345	COG1380	Effector of murein hydrolase LrgA
AL499_RS09355	COG3279	Response regulator of the LytR AlgR family
AL499_RS09360	COG3275	phosphorelay sensor kinase activity
AL499_RS09370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL499_RS09375	COG0456	acetyltransferase
AL499_RS09385	COG0706	membrane insertase activity
AL499_RS09395	COG0531	amino acid
AL499_RS09410	COG1113	amino acid transport
AL499_RS09430	COG2814	Major facilitator Superfamily
AL499_RS09440	COG1929	Belongs to the glycerate kinase type-1 family
AL499_RS09450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL499_RS09455	COG0741	lytic transglycosylase activity
AL499_RS09460	COG0588	phosphoglycerate mutase activity
AL499_RS09465	COG2814	Major facilitator Superfamily
AL499_RS09470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL499_RS09475	COG0765	amino acid transport
AL499_RS09480	COG1126	abc transporter atp-binding protein
AL499_RS09520	COG1131	(ABC) transporter
AL499_RS09530	COG2116	formate transmembrane transporter activity
AL499_RS09540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL499_RS09545	COG2146	nitrite reductase [NAD(P)H] activity
AL499_RS09555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL499_RS09560	COG1140	nitrate reductase beta subunit
AL499_RS09570	COG2181	nitrate reductase activity
AL499_RS09580	COG4585	Histidine kinase
AL499_RS09590	COG2223	nitrite transmembrane transporter activity
AL499_RS09595	COG1846	Transcriptional regulator
AL499_RS09640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS09640	COG1263	PTS System
AL499_RS09665	COG0534	Mate efflux family protein
AL499_RS09675	COG1124	(ABC) transporter
AL499_RS09680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL499_RS09690	COG0601	transmembrane transport
AL499_RS09700	COG0829	nickel cation binding
AL499_RS09715	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL499_RS09720	COG0804	urea catabolic process
AL499_RS09730	COG0831	urea catabolic process
AL499_RS09735	COG4413	Urea transporter
AL499_RS09745	COG4716	Myosin-crossreactive antigen
AL499_RS09750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL499_RS09755	COG2962	Rard protein
AL499_RS09800	COG2814	Major facilitator Superfamily
AL499_RS09805	COG0583	DNA-binding transcription factor activity
AL499_RS09845	COG2314	TM2 domain
AL499_RS09850	COG0492	ferredoxin-NADP+ reductase activity
AL499_RS09865	COG0604	alcohol dehydrogenase
AL499_RS09870	COG2822	iron ion transport
AL499_RS09875	COG2837	iron assimilation
AL499_RS09880	COG0672	)-iron permease
AL499_RS09885	COG0805	protein transport
AL499_RS09890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL499_RS09895	COG0456	acetyltransferase
AL499_RS09905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL499_RS09910	COG1620	l-lactate permease
AL499_RS09915	COG0297	glycogen (starch) synthase activity
AL499_RS09920	COG0579	oxidoreductase
AL499_RS09970	COG2814	Major facilitator Superfamily
AL499_RS09980	COG1566	PFAM secretion protein HlyD family protein
AL499_RS09985	COG2814	Major facilitator Superfamily
AL499_RS10010	COG0598	Magnesium transport protein CorA
AL499_RS10015	COG1304	FMN binding
AL499_RS10020	COG2094	Belongs to the DNA glycosylase MPG family
AL499_RS10030	COG2017	converts alpha-aldose to the beta-anomer
AL499_RS10035	COG2258	MOSC domain
AL499_RS10040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL499_RS10045	COG1266	CAAX protease self-immunity
AL499_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
AL499_RS10075	COG1737	Transcriptional regulator
AL499_RS10080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS10080	COG1263	PTS System
AL499_RS10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL499_RS10105	COG1113	amino acid transport
AL499_RS10110	COG1737	Transcriptional regulator
AL499_RS10115	COG1263	PTS System
AL499_RS10115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL499_RS10120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL499_RS10130	COG1349	DNA-binding transcription factor activity
AL499_RS10140	COG1316	TRANSCRIPTIONal
AL499_RS10170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL499_RS10175	COG2076	Multidrug Resistance protein
AL499_RS10180	COG2076	Multidrug Resistance protein
AL499_RS10185	COG3942	CHAP domain
AL499_RS10200	COG1757	Na H antiporter
AL499_RS10205	COG3942	CHAP domain
AL499_RS10235	COG1960	acyl-CoA dehydrogenase activity
AL499_RS10240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL499_RS10250	COG1268	BioY protein
AL499_RS10260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL499_RS10265	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL499_RS10270	COG4149	molybdate abc transporter
AL499_RS10275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL499_RS10280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL499_RS10315	COG0746	molybdenum cofactor guanylyltransferase activity
AL499_RS10320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL499_RS10345	COG2348	transferase activity, transferring amino-acyl groups
AL499_RS10350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL499_RS10375	COG2252	PERMEase
AL499_RS10390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL499_RS10395	COG0088	Forms part of the polypeptide exit tunnel
AL499_RS10400	COG0089	rRNA binding
AL499_RS10405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL499_RS10410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL499_RS10420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL499_RS10425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL499_RS10435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL499_RS10445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL499_RS10460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL499_RS10465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL499_RS10470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL499_RS10475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL499_RS10480	COG1841	ribosomal large subunit assembly
AL499_RS10490	COG0201	protein transport
AL499_RS10495	COG0563	adenylate kinase activity
AL499_RS10500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL499_RS10505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL499_RS10510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL499_RS10520	COG0202	RNA polymerase activity
AL499_RS10525	COG0203	ribosomal protein L17
AL499_RS10535	COG1122	ATPase activity
AL499_RS10545	COG0101	tRNA pseudouridine synthase activity
AL499_RS10550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL499_RS10555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL499_RS10570	COG1131	(ABC) transporter
AL499_RS10580	COG1131	(ABC) transporter
AL499_RS10590	COG1309	transcriptional regulator
AL499_RS10630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL499_RS10635	COG1349	DNA-binding transcription factor activity
AL499_RS10640	COG0698	ribose 5-phosphate isomerase
AL499_RS10645	COG0698	ribose 5-phosphate isomerase
AL499_RS10650	COG1105	Belongs to the carbohydrate kinase PfkB family
AL499_RS10655	COG3684	Belongs to the aldolase LacD family
AL499_RS10660	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL499_RS10665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL499_RS10665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL499_RS10670	COG2723	6-phospho-beta-galactosidase activity
AL499_RS10680	COG2130	NADP-dependent
AL499_RS10685	COG0604	alcohol dehydrogenase
AL499_RS10715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL499_RS10720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS10725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL499_RS10730	COG3314	Sporulation integral membrane protein YlbJ
AL499_RS10740	COG1988	membrane-bound metal-dependent
AL499_RS10745	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AL499_RS10750	COG1272	protein, Hemolysin III
AL499_RS10765	COG2814	Major facilitator Superfamily
AL499_RS10770	COG0489	protein tyrosine kinase activity
AL499_RS10840	COG0561	phosphatase activity
AL499_RS10860	COG0640	Transcriptional regulator
AL499_RS10865	COG0702	epimerase
AL499_RS10870	COG1482	cell wall glycoprotein biosynthetic process
AL499_RS10890	COG0783	Belongs to the Dps family
AL499_RS10895	COG0813	purine-nucleoside phosphorylase activity
AL499_RS10900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL499_RS10905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL499_RS10910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL499_RS10930	COG1854	S-ribosylhomocysteine lyase activity
AL499_RS10950	COG5146	pantothenate kinase activity
AL499_RS10960	COG3343	RNA polymerase activity
AL499_RS10965	COG0504	CTP synthase activity
AL499_RS10975	COG0191	fructose-bisphosphate aldolase activity
AL499_RS10980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL499_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
AL499_RS10995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL499_RS11000	COG0254	rRNA binding
AL499_RS11010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL499_RS11015	COG2890	protein-(glutamine-N5) methyltransferase activity
AL499_RS11020	COG0009	L-threonylcarbamoyladenylate synthase
AL499_RS11030	COG4475	Protein of unknown function (DUF436)
AL499_RS11035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL499_RS11050	COG0356	it plays a direct role in the translocation of protons across the membrane
AL499_RS11055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL499_RS11060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL499_RS11065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL499_RS11075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL499_RS11080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL499_RS11090	COG4836	Membrane
AL499_RS11095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL499_RS11100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL499_RS11130	COG0629	single-stranded DNA binding
AL499_RS11140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL499_RS11150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL499_RS11155	COG0352	thiamine-phosphate diphosphorylase activity
AL499_RS11160	COG0706	membrane insertase activity
AL499_RS11165	COG1418	mRNA catabolic process
AL499_RS11170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL499_RS11175	COG1937	Protein conserved in bacteria
AL499_RS11185	COG0772	Belongs to the SEDS family
AL499_RS11190	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL499_RS11195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL499_RS11200	COG0513	Belongs to the DEAD box helicase family
AL499_RS11210	COG3428	Bacterial PH domain
AL499_RS11220	COG0736	holo-[acyl-carrier-protein] synthase activity
AL499_RS11235	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL499_RS11240	COG2208	phosphoserine phosphatase activity
AL499_RS11255	COG1191	sigma factor activity
AL499_RS11260	COG2183	response to ionizing radiation
AL499_RS11300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL499_RS11305	COG0066	3-isopropylmalate dehydratase activity
AL499_RS11310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL499_RS11320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL499_RS11325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL499_RS11335	COG0028	Belongs to the TPP enzyme family
AL499_RS11345	COG0802	atpase or kinase
AL499_RS11350	COG1214	PFAM Peptidase M22, glycoprotease
AL499_RS11355	COG0456	acetyltransferase
AL499_RS11360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL499_RS11365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL499_RS11370	COG0488	(ABC) transporter
AL499_RS11375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AL499_RS11385	COG2391	methyltransferase activity
AL499_RS11390	COG0425	Belongs to the sulfur carrier protein TusA family
AL499_RS11395	COG0004	ammonium transporteR
AL499_RS11400	COG1609	Transcriptional regulator
AL499_RS11405	COG1621	beta-fructofuranosidase activity
AL499_RS11410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL499_RS11420	COG3290	protein histidine kinase activity
AL499_RS11430	COG4512	PFAM Accessory gene regulator B
AL499_RS11435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL499_RS11460	COG0459	protein refolding
AL499_RS11465	COG0582	viral genome integration into host DNA
AL499_RS11535	COG5484	DNA packaging
AL499_RS11535	COG3728	DNA packaging
AL499_RS11555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL499_RS11560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL499_RS11565	COG0436	Aminotransferase
AL499_RS11575	COG1725	Transcriptional regulator
AL499_RS11580	COG0842	Transport permease protein
AL499_RS11580	COG1129	ABC transporter
AL499_RS11590	COG1131	(ABC) transporter
AL499_RS11625	COG2706	6-phosphogluconolactonase activity
AL499_RS11630	COG1012	belongs to the aldehyde dehydrogenase family
AL499_RS11635	COG1227	inorganic diphosphatase activity
AL499_RS11640	COG1335	isochorismatase
AL499_RS11660	COG0077	Prephenate dehydratase
AL499_RS11670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL499_RS11675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL499_RS11680	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AL499_RS11690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL499_RS11695	COG4496	protein, YerC YecD
AL499_RS11700	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AL499_RS11710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL499_RS11715	COG4851	CamS sex pheromone cAM373 precursor
AL499_RS11725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL499_RS11735	COG0154	amidase activity
AL499_RS11740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL499_RS11745	COG1597	lipid kinase activity
AL499_RS11750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL499_RS11775	COG1528	Iron-storage protein
AL499_RS11795	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL499_RS11800	COG4129	membrane
AL499_RS11805	COG0024	Methionine aminopeptidase
AL499_RS11830	COG1295	ribonuclease BN
AL499_RS11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL499_RS11845	COG4840	Belongs to the UPF0435 family
AL499_RS11850	COG2309	aminopeptidase activity
AL499_RS11855	COG1607	acyl-coa hydrolase
AL499_RS11860	COG0535	radical SAM domain protein
AL499_RS11865	COG0693	protein deglycase activity
AL499_RS11870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL499_RS11875	COG2137	regulation of response to DNA damage stimulus
AL499_RS11885	COG1388	LysM domain
AL499_RS11885	COG1134	teichoic acid transport
AL499_RS11895	COG1988	membrane-bound metal-dependent
AL499_RS11900	COG1194	a g-specific adenine glycosylase
AL499_RS11905	COG3557	Belongs to the UPF0374 family
AL499_RS11915	COG4129	membrane
AL499_RS11920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL499_RS11925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL499_RS11935	COG0735	belongs to the Fur family
AL499_RS12100	COG0765	amino acid transport
AL499_RS12105	COG1126	abc transporter atp-binding protein
AL499_RS12110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL499_RS12120	COG0363	glucosamine-6-phosphate deaminase activity
AL499_RS12130	COG0114	fumarate hydratase activity
AL499_RS12135	COG0564	pseudouridine synthase activity
AL499_RS12140	COG2203	Gaf domain
AL499_RS12140	COG4585	Histidine kinase
AL499_RS12145	COG2197	response regulator
AL499_RS12160	COG3679	Belongs to the UPF0342 family
AL499_RS12165	COG0420	3'-5' exonuclease activity
AL499_RS12190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation