locus-tag	class	description
AL501_RS00015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL501_RS00020	COG1098	S1 RNA binding domain
AL501_RS00025	COG1902	pentaerythritol trinitrate reductase activity
AL501_RS00055	COG0137	argininosuccinate synthase activity
AL501_RS00060	COG0166	Belongs to the GPI family
AL501_RS00065	COG0398	Pfam SNARE associated Golgi protein
AL501_RS00085	COG1074	ATP-dependent DNA helicase activity
AL501_RS00100	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL501_RS00105	COG0561	phosphatase activity
AL501_RS00115	COG0542	response to heat
AL501_RS00125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL501_RS00140	COG0601	transmembrane transport
AL501_RS00145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL501_RS00150	COG0444	Belongs to the ABC transporter superfamily
AL501_RS00155	COG4608	Belongs to the ABC transporter superfamily
AL501_RS00160	COG4166	transmembrane transport
AL501_RS00165	COG2226	methyltransferase
AL501_RS00170	COG0180	Tryptophanyl-tRNA synthetase
AL501_RS00175	COG1393	Belongs to the ArsC family
AL501_RS00190	COG1164	Oligoendopeptidase f
AL501_RS00200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL501_RS00205	COG2346	COG2346, Truncated hemoglobins
AL501_RS00220	COG2357	RelA SpoT domain protein
AL501_RS00230	COG0564	pseudouridine synthase activity
AL501_RS00235	COG2239	Acts as a magnesium transporter
AL501_RS00240	COG0569	domain protein
AL501_RS00240	COG0475	glutathione-regulated potassium exporter activity
AL501_RS00250	COG0628	permease
AL501_RS00260	COG4221	oxidoreductase activity
AL501_RS00265	COG0789	Transcriptional regulator
AL501_RS00270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL501_RS00275	COG2814	Major facilitator Superfamily
AL501_RS00280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL501_RS00285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL501_RS00300	COG0861	Integral membrane protein TerC family
AL501_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS00315	COG0737	Belongs to the 5'-nucleotidase family
AL501_RS00325	COG4873	Protein conserved in bacteria
AL501_RS00410	COG1575	Belongs to the MenA family. Type 1 subfamily
AL501_RS00415	COG1169	isochorismate synthase
AL501_RS00420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL501_RS00425	COG0596	Alpha beta hydrolase
AL501_RS00430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL501_RS00435	COG0436	Aminotransferase
AL501_RS00440	COG3594	Acyltransferase
AL501_RS00465	COG1316	TRANSCRIPTIONal
AL501_RS00470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL501_RS00480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL501_RS00485	COG1845	cytochrome c oxidase, subunit III
AL501_RS00495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL501_RS00505	COG1017	nitric oxide dioxygenase activity
AL501_RS00505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL501_RS00515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL501_RS00520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL501_RS00525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL501_RS00530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL501_RS00535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL501_RS00540	COG0047	phosphoribosylformylglycinamidine synthase activity
AL501_RS00545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL501_RS00555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL501_RS00565	COG0138	bifunctional purine biosynthesis protein purh
AL501_RS00570	COG0151	Belongs to the GarS family
AL501_RS00575	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL501_RS00580	COG4172	Belongs to the ABC transporter superfamily
AL501_RS00595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL501_RS00610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL501_RS00625	COG0569	domain protein
AL501_RS00630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL501_RS00635	COG5503	Protein of unknown function (DUF1447)
AL501_RS00640	COG0242	peptide deformylase activity
AL501_RS00655	COG0022	dehydrogenase e1 component
AL501_RS00670	COG4476	Belongs to the UPF0223 family
AL501_RS00690	COG1177	transmembrane transport
AL501_RS00695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL501_RS00715	COG4493	Belongs to the UPF0637 family
AL501_RS00720	COG0483	inositol monophosphate 1-phosphatase activity
AL501_RS00730	COG1217	gtp-binding protein TYPA
AL501_RS00740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL501_RS00745	COG4838	Belongs to the UPF0358 family
AL501_RS00750	COG0772	Belongs to the SEDS family
AL501_RS00760	COG1612	heme a metabolic process
AL501_RS00765	COG0109	protoheme IX farnesyltransferase activity
AL501_RS00780	COG3679	Belongs to the UPF0342 family
AL501_RS00800	COG0742	ribosomal rna small subunit methyltransferase
AL501_RS00805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL501_RS00810	COG1323	Belongs to the UPF0348 family
AL501_RS00820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL501_RS00825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL501_RS00830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL501_RS00835	COG0072	phenylalanine-tRNA ligase activity
AL501_RS00835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS00840	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL501_RS00845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL501_RS00855	COG1796	DNA polymerase
AL501_RS00855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL501_RS00860	COG1193	negative regulation of DNA recombination
AL501_RS00865	COG3118	belongs to the thioredoxin family
AL501_RS00875	COG2009	succinate dehydrogenase
AL501_RS00880	COG1053	succinate dehydrogenase
AL501_RS00885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL501_RS00890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL501_RS00895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL501_RS00905	COG1011	Hydrolase
AL501_RS00915	COG0454	-acetyltransferase
AL501_RS00920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL501_RS00930	COG0275	rRNA processing
AL501_RS00935	COG4839	cell division protein FtsL
AL501_RS00940	COG0768	penicillin binding
AL501_RS00945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL501_RS00950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL501_RS00955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL501_RS00960	COG0849	cell division
AL501_RS00965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL501_RS00970	COG1496	oxidoreductase activity
AL501_RS00975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL501_RS00980	COG1799	cell septum assembly
AL501_RS00985	COG0762	integral membrane protein
AL501_RS00990	COG2302	S4 RNA-binding domain
AL501_RS00995	COG3599	regulation of cell shape
AL501_RS01000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL501_RS01010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL501_RS01015	COG0564	pseudouridine synthase activity
AL501_RS01020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AL501_RS01025	COG2233	PERMEase
AL501_RS01030	COG0540	Belongs to the ATCase OTCase family
AL501_RS01040	COG0505	Belongs to the CarA family
AL501_RS01050	COG0284	orotidine-5'-phosphate decarboxylase activity
AL501_RS01055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL501_RS01075	COG0194	GDP metabolic process
AL501_RS01080	COG1758	RNA polymerase activity
AL501_RS01085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL501_RS01090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL501_RS01100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL501_RS01105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL501_RS01105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL501_RS01115	COG0631	protein serine/threonine phosphatase activity
AL501_RS01130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL501_RS01140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL501_RS01145	COG1302	Protein conserved in bacteria
AL501_RS01150	COG1461	Dihydroxyacetone kinase
AL501_RS01155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL501_RS01160	COG1349	DNA-binding transcription factor activity
AL501_RS01165	COG0416	fatty acid biosynthetic process
AL501_RS01180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL501_RS01185	COG0571	ribonuclease III activity
AL501_RS01190	COG1196	nuclear chromosome segregation
AL501_RS01195	COG0552	protein localization to endoplasmic reticulum
AL501_RS01200	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AL501_RS01205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL501_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
AL501_RS01215	COG0183	Belongs to the thiolase family
AL501_RS01230	COG0228	four-way junction DNA binding
AL501_RS01235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL501_RS01240	COG0336	Belongs to the RNA methyltransferase TrmD family
AL501_RS01245	COG0335	large ribosomal subunit rRNA binding
AL501_RS01255	COG4485	Bacterial membrane protein, YfhO
AL501_RS01270	COG0045	succinate-CoA ligase (ADP-forming) activity
AL501_RS01275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL501_RS01280	COG2348	transferase activity, transferring amino-acyl groups
AL501_RS01295	COG0758	DNA mediated transformation
AL501_RS01305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL501_RS01310	COG4974	Belongs to the 'phage' integrase family
AL501_RS01315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL501_RS01320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL501_RS01325	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL501_RS01330	COG0052	Belongs to the universal ribosomal protein uS2 family
AL501_RS01335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL501_RS01340	COG0528	UMP kinase activity
AL501_RS01345	COG0233	cytoplasmic translational termination
AL501_RS01350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL501_RS01355	COG4589	Belongs to the CDS family
AL501_RS01370	COG0442	prolyl-tRNA aminoacylation
AL501_RS01375	COG2176	DNA-directed DNA polymerase activity
AL501_RS01380	COG0779	Required for maturation of 30S ribosomal subunits
AL501_RS01385	COG0195	Participates in both transcription termination and antitermination
AL501_RS01390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AL501_RS01400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL501_RS01405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL501_RS01415	COG0196	riboflavin kinase activity
AL501_RS01425	COG1185	polyribonucleotide nucleotidyltransferase activity
AL501_RS01430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL501_RS01435	COG1674	ftsk spoiiie
AL501_RS01440	COG2188	Transcriptional regulator
AL501_RS01445	COG0612	Peptidase, M16
AL501_RS01450	COG0612	Peptidase, M16
AL501_RS01455	COG0300	oxidoreductase activity
AL501_RS01475	COG1546	Belongs to the CinA family
AL501_RS01475	COG1058	Belongs to the CinA family
AL501_RS01480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL501_RS01485	COG1418	mRNA catabolic process
AL501_RS01495	COG1692	metallophosphoesterase
AL501_RS01500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL501_RS01500	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL501_RS01505	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL501_RS01510	COG4195	phage-related replication protein
AL501_RS01520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL501_RS01535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL501_RS01540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL501_RS01550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL501_RS01555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL501_RS01560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL501_RS01570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL501_RS01575	COG1923	regulation of RNA biosynthetic process
AL501_RS01585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL501_RS01590	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AL501_RS01595	COG0789	Transcriptional regulator
AL501_RS01610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL501_RS01615	COG1131	(ABC) transporter
AL501_RS01625	COG4585	Histidine kinase
AL501_RS01625	COG2203	Gaf domain
AL501_RS01630	COG2197	response regulator
AL501_RS01645	COG1525	nuclease
AL501_RS01660	COG0527	aspartate kinase activity
AL501_RS01665	COG0460	homoserine dehydrogenase
AL501_RS01670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL501_RS01675	COG0083	homoserine kinase activity
AL501_RS01690	COG0833	amino acid
AL501_RS01705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL501_RS01715	COG2340	Cysteine-rich secretory protein family
AL501_RS01720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL501_RS01730	COG4224	UPF0291 protein
AL501_RS01735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL501_RS01740	COG3763	UPF0154 protein
AL501_RS01745	COG4846	Membrane protein involved in cytochrome C biogenesis
AL501_RS01760	COG1970	mechanosensitive ion channel activity
AL501_RS01765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL501_RS01770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL501_RS01780	COG4841	protein insertion into membrane
AL501_RS01785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL501_RS01790	COG0187	DNA topoisomerase II activity
AL501_RS01795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL501_RS01800	COG1115	amino acid carrier protein
AL501_RS01805	COG0628	permease
AL501_RS01810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL501_RS01810	COG0392	lysyltransferase activity
AL501_RS01825	COG1942	4-Oxalocrotonate Tautomerase
AL501_RS01830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL501_RS01835	COG0287	Prephenate dehydrogenase
AL501_RS01855	COG3623	hexulose-6-phosphate isomerase
AL501_RS01865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS01885	COG1363	Peptidase, m42
AL501_RS01890	COG0328	RNA-DNA hybrid ribonuclease activity
AL501_RS01895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL501_RS01900	COG1413	lyase activity
AL501_RS01930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL501_RS01940	COG4479	Belongs to the UPF0346 family
AL501_RS01945	COG0793	Belongs to the peptidase S41A family
AL501_RS01955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL501_RS01960	COG0671	phosphoesterase, PA-phosphatase related
AL501_RS01965	COG0745	RESPONSE REGULATOR receiver
AL501_RS01970	COG5002	protein histidine kinase activity
AL501_RS01975	COG0567	Dehydrogenase, E1 component
AL501_RS01995	COG0714	Associated with various cellular activities
AL501_RS02000	COG4548	von Willebrand factor, type A
AL501_RS02005	COG1114	Component of the transport system for branched-chain amino acids
AL501_RS02010	COG3853	Toxic anion resistance protein (TelA)
AL501_RS02020	COG1254	Belongs to the acylphosphatase family
AL501_RS02030	COG1278	Cold shock
AL501_RS02050	COG1473	amidohydrolase
AL501_RS02055	COG2171	N-acyltransferase activity
AL501_RS02060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL501_RS02065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL501_RS02070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL501_RS02075	COG0527	aspartate kinase activity
AL501_RS02080	COG0488	(ABC) transporter
AL501_RS02085	COG2996	Protein conserved in bacteria
AL501_RS02090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL501_RS02095	COG0573	inorganic phosphate transmembrane transporter activity
AL501_RS02100	COG0581	inorganic phosphate transmembrane transporter activity
AL501_RS02115	COG1164	Oligoendopeptidase f
AL501_RS02130	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS02135	COG0561	phosphatase activity
AL501_RS02160	COG0135	phosphoribosylanthranilate isomerase activity
AL501_RS02165	COG0134	indole-3-glycerol-phosphate synthase activity
AL501_RS02170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL501_RS02175	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS02180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL501_RS02185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS02190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AL501_RS02200	COG0116	Belongs to the methyltransferase superfamily
AL501_RS02210	COG3599	regulation of cell shape
AL501_RS02215	COG4474	Belongs to the UPF0398 family
AL501_RS02230	COG4499	WXG100 protein secretion system (Wss), protein YukC
AL501_RS02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL501_RS02240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL501_RS02245	COG3935	DnaD domain protein
AL501_RS02250	COG0017	Asparaginyl-tRNA synthetase
AL501_RS02255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL501_RS02255	COG1199	ATP-dependent helicase activity
AL501_RS02260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL501_RS02260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL501_RS02265	COG0617	tRNA 3'-terminal CCA addition
AL501_RS02270	COG0438	transferase activity, transferring glycosyl groups
AL501_RS02275	COG1694	Mazg nucleotide pyrophosphohydrolase
AL501_RS02280	COG2738	Putative neutral zinc metallopeptidase
AL501_RS02305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL501_RS02310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL501_RS02320	COG0142	geranyltranstransferase activity
AL501_RS02325	COG2226	methyltransferase
AL501_RS02340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL501_RS02350	COG0539	negative regulation of cytoplasmic translation
AL501_RS02370	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS02375	COG1388	LysM domain
AL501_RS02380	COG0514	ATP-dependent DNA helicase (RecQ)
AL501_RS02390	COG1141	Ferredoxin
AL501_RS02405	COG0745	RESPONSE REGULATOR receiver
AL501_RS02410	COG1187	pseudouridine synthase activity
AL501_RS02415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL501_RS02420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL501_RS02430	COG4974	Belongs to the 'phage' integrase family
AL501_RS02435	COG0735	belongs to the Fur family
AL501_RS02440	COG0494	nUDIX hydrolase
AL501_RS02445	COG0667	Aldo Keto reductase
AL501_RS02450	COG0300	oxidoreductase activity
AL501_RS02455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL501_RS02465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL501_RS02480	COG1609	Transcriptional regulator
AL501_RS02490	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL501_RS02495	COG4129	membrane
AL501_RS02505	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL501_RS02510	COG0022	dehydrogenase e1 component
AL501_RS02515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL501_RS02520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS02525	COG0280	phosphate acetyltransferase
AL501_RS02530	COG0497	DNA recombination
AL501_RS02535	COG1438	arginine binding
AL501_RS02555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL501_RS02560	COG1302	Protein conserved in bacteria
AL501_RS02565	COG0439	Biotin carboxylase
AL501_RS02570	COG0511	ligase activity, forming carbon-carbon bonds
AL501_RS02575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL501_RS02580	COG0006	proline dipeptidase activity
AL501_RS02595	COG0095	Lipoate-protein ligase
AL501_RS02600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL501_RS02605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL501_RS02610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL501_RS02615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL501_RS02620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL501_RS02645	COG4537	Required for transformation and DNA binding
AL501_RS02650	COG1459	type II secretion system
AL501_RS02655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL501_RS02660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL501_RS02665	COG0011	TIGRFAM Protein of
AL501_RS02670	COG1940	carbohydrate kinase activity
AL501_RS02675	COG4483	Protein conserved in bacteria
AL501_RS02680	COG0457	Tetratricopeptide repeat
AL501_RS02680	COG0705	Rhomboid family
AL501_RS02685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL501_RS02690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL501_RS02695	COG0768	penicillin binding
AL501_RS02700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL501_RS02710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL501_RS02715	COG1121	(ABC) transporter
AL501_RS02720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL501_RS02725	COG0513	Belongs to the DEAD box helicase family
AL501_RS02735	COG2384	SAM-dependent methyltransferase
AL501_RS02750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL501_RS02770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL501_RS02775	COG0295	cytidine deaminase activity
AL501_RS02780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL501_RS02785	COG1702	phosphate starvation-inducible protein PhoH
AL501_RS02795	COG4864	UPF0365 protein
AL501_RS02800	COG1030	water channel activity
AL501_RS02810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL501_RS02815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL501_RS02820	COG2264	protein methyltransferase activity
AL501_RS02825	COG0484	heat shock protein binding
AL501_RS02830	COG0443	Heat shock 70 kDa protein
AL501_RS02835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL501_RS02845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL501_RS02850	COG0481	GTPase activity
AL501_RS02855	COG0268	Binds directly to 16S ribosomal RNA
AL501_RS02860	COG1466	dna polymerase III delta subunit
AL501_RS02865	COG2333	competence protein COMEC
AL501_RS02865	COG0658	competence protein
AL501_RS02870	COG2131	deaminase
AL501_RS02875	COG1555	photosystem II stabilization
AL501_RS02875	COG1596	polysaccharide export
AL501_RS02880	COG2226	methyltransferase
AL501_RS02885	COG0799	negative regulation of ribosome biogenesis
AL501_RS02890	COG1713	HD superfamily hydrolase involved in NAD metabolism
AL501_RS02900	COG1534	Rna-binding protein
AL501_RS02910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL501_RS02915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AL501_RS02920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL501_RS02925	COG1914	H( )-stimulated, divalent metal cation uptake system
AL501_RS02935	COG0439	Biotin carboxylase
AL501_RS02940	COG0511	ligase activity, forming carbon-carbon bonds
AL501_RS02945	COG1984	allophanate hydrolase subunit 2
AL501_RS02950	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL501_RS02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL501_RS02960	COG0572	uridine kinase
AL501_RS02965	COG0826	peptidase U32
AL501_RS02970	COG0826	peptidase U32
AL501_RS02975	COG4122	O-methyltransferase activity
AL501_RS02985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL501_RS02990	COG4472	Bacterial protein of unknown function (DUF965)
AL501_RS02995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL501_RS03000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL501_RS03010	COG0482	sulfurtransferase activity
AL501_RS03015	COG1104	cysteine desulfurase activity
AL501_RS03020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL501_RS03025	COG1959	2 iron, 2 sulfur cluster binding
AL501_RS03030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL501_RS03035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL501_RS03045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL501_RS03050	COG0124	histidyl-tRNA synthetase
AL501_RS03055	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL501_RS03060	COG1490	D-aminoacyl-tRNA deacylase activity
AL501_RS03065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL501_RS03075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL501_RS03075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL501_RS03080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL501_RS03080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL501_RS03085	COG1862	Preprotein translocase
AL501_RS03090	COG0343	queuine tRNA-ribosyltransferase activity
AL501_RS03095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL501_RS03100	COG2255	four-way junction helicase activity
AL501_RS03105	COG0632	four-way junction helicase activity
AL501_RS03110	COG4492	Belongs to the UPF0735 family
AL501_RS03115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL501_RS03125	COG2868	ribosomal protein
AL501_RS03130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL501_RS03140	COG1792	Involved in formation and maintenance of cell shape
AL501_RS03150	COG2003	Belongs to the UPF0758 family
AL501_RS03160	COG0285	dihydrofolate synthase activity
AL501_RS03165	COG0525	valine-tRNA ligase activity
AL501_RS03170	COG2818	Glycosylase
AL501_RS03180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL501_RS03195	COG0181	hydroxymethylbilane synthase activity
AL501_RS03200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL501_RS03215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL501_RS03220	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL501_RS03230	COG4112	unkown
AL501_RS03235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL501_RS03240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL501_RS03245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL501_RS03250	COG0833	amino acid
AL501_RS03260	COG1484	DNA-dependent DNA replication
AL501_RS03265	COG3611	Membrane attachment protein
AL501_RS03270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL501_RS03275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL501_RS03280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL501_RS03290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL501_RS03295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS03295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS03300	COG5002	protein histidine kinase activity
AL501_RS03305	COG0745	RESPONSE REGULATOR receiver
AL501_RS03310	COG0538	isocitrate dehydrogenase activity
AL501_RS03315	COG0372	Belongs to the citrate synthase family
AL501_RS03320	COG1113	amino acid transport
AL501_RS03325	COG0469	pyruvate kinase activity
AL501_RS03330	COG0205	6-phosphofructokinase activity
AL501_RS03335	COG0825	malonyl-CoA metabolic process
AL501_RS03340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL501_RS03345	COG0281	malic enzyme
AL501_RS03350	COG0587	DNA-directed DNA polymerase activity
AL501_RS03355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL501_RS03360	COG4109	DRTGG domain
AL501_RS03370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL501_RS03375	COG0006	proline dipeptidase activity
AL501_RS03380	COG0686	Belongs to the AlaDH PNT family
AL501_RS03385	COG0589	response to stress
AL501_RS03390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL501_RS03395	COG0827	DNA restriction-modification system
AL501_RS03400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL501_RS03405	COG0730	response to heat
AL501_RS03410	COG0301	tRNA thio-modification
AL501_RS03415	COG1104	cysteine desulfurase activity
AL501_RS03420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL501_RS03425	COG1956	GAF domain-containing protein
AL501_RS03430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL501_RS03435	COG0584	glycerophosphoryl diester phosphodiesterase
AL501_RS03440	COG1764	response to oxidative stress
AL501_RS03445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL501_RS03450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL501_RS03460	COG1263	PTS System
AL501_RS03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS03465	COG0204	Acyl-transferase
AL501_RS03470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS03480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL501_RS03490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL501_RS03495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL501_RS03500	COG0454	-acetyltransferase
AL501_RS03505	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL501_RS03520	COG1609	Transcriptional regulator
AL501_RS03525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL501_RS03525	COG1605	Chorismate mutase
AL501_RS03535	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AL501_RS03540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL501_RS03545	COG1674	ftsk spoiiie
AL501_RS03550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS03555	COG4848	Belongs to the UPF0354 family
AL501_RS03560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS03565	COG1363	Peptidase, m42
AL501_RS03570	COG5584	Small secreted protein
AL501_RS03575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL501_RS03580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL501_RS03585	COG0510	thiamine kinase activity
AL501_RS03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL501_RS03605	COG1187	pseudouridine synthase activity
AL501_RS03610	COG2244	polysaccharide biosynthetic process
AL501_RS03615	COG2081	HI0933 family
AL501_RS03625	COG0495	leucyl-tRNA aminoacylation
AL501_RS03630	COG2814	Major facilitator Superfamily
AL501_RS03635	COG1242	4 iron, 4 sulfur cluster binding
AL501_RS03640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AL501_RS03650	COG2267	carboxylic ester hydrolase activity
AL501_RS03660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL501_RS03665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL501_RS03665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL501_RS03675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL501_RS03675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL501_RS03685	COG3266	domain, Protein
AL501_RS03685	COG4193	domain, Protein
AL501_RS03685	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL501_RS03710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL501_RS03725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL501_RS03730	COG0656	L-ascorbic acid biosynthetic process
AL501_RS03740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL501_RS03745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL501_RS03750	COG1506	peptidase
AL501_RS03760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL501_RS03770	COG0318	PFAM AMP-dependent synthetase and ligase
AL501_RS03885	COG3545	Serine hydrolase
AL501_RS03890	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL501_RS03900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL501_RS03905	COG2329	Antibiotic biosynthesis monooxygenase
AL501_RS03910	COG4473	ABC transporter
AL501_RS03915	COG1131	(ABC) transporter
AL501_RS03920	COG0537	adenosine 5'-monophosphoramidase activity
AL501_RS03935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL501_RS03960	COG0420	3'-5' exonuclease activity
AL501_RS03965	COG3679	Belongs to the UPF0342 family
AL501_RS03980	COG2197	response regulator
AL501_RS03985	COG4585	Histidine kinase
AL501_RS03985	COG2203	Gaf domain
AL501_RS03990	COG0564	pseudouridine synthase activity
AL501_RS03995	COG0114	fumarate hydratase activity
AL501_RS04005	COG0363	glucosamine-6-phosphate deaminase activity
AL501_RS04015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL501_RS04020	COG1126	abc transporter atp-binding protein
AL501_RS04025	COG0765	amino acid transport
AL501_RS04190	COG0735	belongs to the Fur family
AL501_RS04200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL501_RS04205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL501_RS04210	COG4129	membrane
AL501_RS04220	COG3557	Belongs to the UPF0374 family
AL501_RS04225	COG1194	a g-specific adenine glycosylase
AL501_RS04230	COG1988	membrane-bound metal-dependent
AL501_RS04240	COG1388	LysM domain
AL501_RS04240	COG1134	teichoic acid transport
AL501_RS04250	COG2137	regulation of response to DNA damage stimulus
AL501_RS04255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL501_RS04260	COG0693	protein deglycase activity
AL501_RS04265	COG0535	radical SAM domain protein
AL501_RS04270	COG1607	acyl-coa hydrolase
AL501_RS04275	COG2309	aminopeptidase activity
AL501_RS04280	COG4840	Belongs to the UPF0435 family
AL501_RS04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL501_RS04295	COG1295	ribonuclease BN
AL501_RS04320	COG0024	Methionine aminopeptidase
AL501_RS04325	COG4129	membrane
AL501_RS04330	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL501_RS04350	COG1528	Iron-storage protein
AL501_RS04375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL501_RS04380	COG1597	lipid kinase activity
AL501_RS04385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL501_RS04390	COG0154	amidase activity
AL501_RS04400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL501_RS04410	COG4851	CamS sex pheromone cAM373 precursor
AL501_RS04415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL501_RS04425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AL501_RS04430	COG4496	protein, YerC YecD
AL501_RS04435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL501_RS04445	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AL501_RS04450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL501_RS04465	COG0077	Prephenate dehydratase
AL501_RS04485	COG1335	isochorismatase
AL501_RS04490	COG1227	inorganic diphosphatase activity
AL501_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS04500	COG2706	6-phosphogluconolactonase activity
AL501_RS04535	COG1131	(ABC) transporter
AL501_RS04545	COG0842	Transport permease protein
AL501_RS04545	COG1129	ABC transporter
AL501_RS04550	COG1725	Transcriptional regulator
AL501_RS04565	COG0459	protein refolding
AL501_RS04590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL501_RS04595	COG4512	PFAM Accessory gene regulator B
AL501_RS04605	COG3290	protein histidine kinase activity
AL501_RS04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL501_RS04620	COG1621	beta-fructofuranosidase activity
AL501_RS04625	COG1609	Transcriptional regulator
AL501_RS04630	COG0004	ammonium transporteR
AL501_RS04635	COG0425	Belongs to the sulfur carrier protein TusA family
AL501_RS04640	COG2391	methyltransferase activity
AL501_RS04645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AL501_RS04650	COG0488	(ABC) transporter
AL501_RS04655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL501_RS04660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL501_RS04665	COG0456	acetyltransferase
AL501_RS04670	COG1214	PFAM Peptidase M22, glycoprotease
AL501_RS04675	COG0802	atpase or kinase
AL501_RS04685	COG0028	Belongs to the TPP enzyme family
AL501_RS04695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL501_RS04700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL501_RS04715	COG0066	3-isopropylmalate dehydratase activity
AL501_RS04720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL501_RS04760	COG2183	response to ionizing radiation
AL501_RS04765	COG1191	sigma factor activity
AL501_RS04780	COG2208	phosphoserine phosphatase activity
AL501_RS04800	COG0736	holo-[acyl-carrier-protein] synthase activity
AL501_RS04810	COG3428	Bacterial PH domain
AL501_RS04820	COG0513	Belongs to the DEAD box helicase family
AL501_RS04825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL501_RS04830	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL501_RS04835	COG0772	Belongs to the SEDS family
AL501_RS04845	COG1937	Protein conserved in bacteria
AL501_RS04850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL501_RS04855	COG1418	mRNA catabolic process
AL501_RS04860	COG0706	membrane insertase activity
AL501_RS04865	COG0352	thiamine-phosphate diphosphorylase activity
AL501_RS04870	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL501_RS04880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL501_RS04890	COG0629	single-stranded DNA binding
AL501_RS04900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL501_RS04905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL501_RS04910	COG4836	Membrane
AL501_RS04920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL501_RS04925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL501_RS04935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL501_RS04940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL501_RS04945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL501_RS04950	COG0356	it plays a direct role in the translocation of protons across the membrane
AL501_RS04965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL501_RS04970	COG4475	Protein of unknown function (DUF436)
AL501_RS04975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL501_RS04980	COG0009	L-threonylcarbamoyladenylate synthase
AL501_RS04985	COG2890	protein-(glutamine-N5) methyltransferase activity
AL501_RS04990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL501_RS05000	COG0254	rRNA binding
AL501_RS05005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL501_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS05020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL501_RS05025	COG0191	fructose-bisphosphate aldolase activity
AL501_RS05035	COG0504	CTP synthase activity
AL501_RS05040	COG3343	RNA polymerase activity
AL501_RS05050	COG5146	pantothenate kinase activity
AL501_RS05070	COG1854	S-ribosylhomocysteine lyase activity
AL501_RS05090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL501_RS05095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL501_RS05100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL501_RS05105	COG0813	purine-nucleoside phosphorylase activity
AL501_RS05110	COG0783	Belongs to the Dps family
AL501_RS05130	COG1482	cell wall glycoprotein biosynthetic process
AL501_RS05135	COG0702	epimerase
AL501_RS05140	COG0640	Transcriptional regulator
AL501_RS05160	COG0561	phosphatase activity
AL501_RS05230	COG0489	protein tyrosine kinase activity
AL501_RS05235	COG2814	Major facilitator Superfamily
AL501_RS05250	COG1272	protein, Hemolysin III
AL501_RS05255	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AL501_RS05260	COG1988	membrane-bound metal-dependent
AL501_RS05270	COG3314	Sporulation integral membrane protein YlbJ
AL501_RS05275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS05280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS05285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL501_RS05315	COG0604	alcohol dehydrogenase
AL501_RS05320	COG2130	NADP-dependent
AL501_RS05330	COG2723	6-phospho-beta-galactosidase activity
AL501_RS05335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL501_RS05335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL501_RS05340	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL501_RS05345	COG3684	Belongs to the aldolase LacD family
AL501_RS05350	COG1105	Belongs to the carbohydrate kinase PfkB family
AL501_RS05355	COG0698	ribose 5-phosphate isomerase
AL501_RS05360	COG0698	ribose 5-phosphate isomerase
AL501_RS05365	COG1349	DNA-binding transcription factor activity
AL501_RS05370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL501_RS05410	COG1309	transcriptional regulator
AL501_RS05420	COG1131	(ABC) transporter
AL501_RS05430	COG1131	(ABC) transporter
AL501_RS05445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL501_RS05450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL501_RS05455	COG0101	tRNA pseudouridine synthase activity
AL501_RS05465	COG1122	ATPase activity
AL501_RS05475	COG0203	ribosomal protein L17
AL501_RS05480	COG0202	RNA polymerase activity
AL501_RS05490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL501_RS05495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL501_RS05500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL501_RS05505	COG0563	adenylate kinase activity
AL501_RS05510	COG0201	protein transport
AL501_RS05520	COG1841	ribosomal large subunit assembly
AL501_RS05525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL501_RS05530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL501_RS05535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL501_RS05540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL501_RS05555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL501_RS05565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL501_RS05575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL501_RS05580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL501_RS05590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL501_RS05595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL501_RS05600	COG0089	rRNA binding
AL501_RS05605	COG0088	Forms part of the polypeptide exit tunnel
AL501_RS05610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL501_RS05625	COG2252	PERMEase
AL501_RS05650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL501_RS05655	COG2348	transferase activity, transferring amino-acyl groups
AL501_RS05680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL501_RS05685	COG0746	molybdenum cofactor guanylyltransferase activity
AL501_RS05720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL501_RS05725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL501_RS05730	COG4149	molybdate abc transporter
AL501_RS05735	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL501_RS05740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL501_RS05750	COG1268	BioY protein
AL501_RS05760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS05765	COG1960	acyl-CoA dehydrogenase activity
AL501_RS05795	COG3942	CHAP domain
AL501_RS05800	COG1757	Na H antiporter
AL501_RS05815	COG3942	CHAP domain
AL501_RS05820	COG2076	Multidrug Resistance protein
AL501_RS05825	COG2076	Multidrug Resistance protein
AL501_RS05830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS05855	COG1316	TRANSCRIPTIONal
AL501_RS05865	COG1349	DNA-binding transcription factor activity
AL501_RS05875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL501_RS05880	COG1263	PTS System
AL501_RS05880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS05885	COG1737	Transcriptional regulator
AL501_RS05890	COG1113	amino acid transport
AL501_RS05910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL501_RS05920	COG1263	PTS System
AL501_RS05920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS05925	COG1737	Transcriptional regulator
AL501_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS05950	COG1473	amidohydrolase
AL501_RS05955	COG1266	CAAX protease self-immunity
AL501_RS05960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL501_RS05965	COG2258	MOSC domain
AL501_RS05970	COG2017	converts alpha-aldose to the beta-anomer
AL501_RS05980	COG2094	Belongs to the DNA glycosylase MPG family
AL501_RS05985	COG1304	FMN binding
AL501_RS05990	COG0598	Magnesium transport protein CorA
AL501_RS06015	COG2814	Major facilitator Superfamily
AL501_RS06020	COG1566	PFAM secretion protein HlyD family protein
AL501_RS06030	COG2814	Major facilitator Superfamily
AL501_RS06080	COG0579	oxidoreductase
AL501_RS06085	COG0297	glycogen (starch) synthase activity
AL501_RS06090	COG1620	l-lactate permease
AL501_RS06095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS06105	COG0456	acetyltransferase
AL501_RS06110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL501_RS06115	COG0805	protein transport
AL501_RS06120	COG0672	)-iron permease
AL501_RS06125	COG2837	iron assimilation
AL501_RS06130	COG2822	iron ion transport
AL501_RS06135	COG0604	alcohol dehydrogenase
AL501_RS06145	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS06150	COG2314	TM2 domain
AL501_RS06165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL501_RS06200	COG0583	DNA-binding transcription factor activity
AL501_RS06205	COG2814	Major facilitator Superfamily
AL501_RS06230	COG0488	(ABC) transporter
AL501_RS06245	COG2962	Rard protein
AL501_RS06255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL501_RS06260	COG4716	Myosin-crossreactive antigen
AL501_RS06270	COG4413	Urea transporter
AL501_RS06275	COG0831	urea catabolic process
AL501_RS06285	COG0804	urea catabolic process
AL501_RS06290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL501_RS06305	COG0829	nickel cation binding
AL501_RS06315	COG0601	transmembrane transport
AL501_RS06325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS06330	COG1124	(ABC) transporter
AL501_RS06340	COG0534	Mate efflux family protein
AL501_RS06365	COG1263	PTS System
AL501_RS06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS06405	COG1846	Transcriptional regulator
AL501_RS06410	COG2223	nitrite transmembrane transporter activity
AL501_RS06420	COG4585	Histidine kinase
AL501_RS06430	COG2181	nitrate reductase activity
AL501_RS06440	COG1140	nitrate reductase beta subunit
AL501_RS06445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL501_RS06455	COG2146	nitrite reductase [NAD(P)H] activity
AL501_RS06460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL501_RS06470	COG2116	formate transmembrane transporter activity
AL501_RS06480	COG1131	(ABC) transporter
AL501_RS06520	COG1126	abc transporter atp-binding protein
AL501_RS06525	COG0765	amino acid transport
AL501_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL501_RS06535	COG2814	Major facilitator Superfamily
AL501_RS06540	COG0588	phosphoglycerate mutase activity
AL501_RS06545	COG0741	lytic transglycosylase activity
AL501_RS06550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL501_RS06560	COG1929	Belongs to the glycerate kinase type-1 family
AL501_RS06570	COG2814	Major facilitator Superfamily
AL501_RS06590	COG1113	amino acid transport
AL501_RS06605	COG0531	amino acid
AL501_RS06615	COG0706	membrane insertase activity
AL501_RS06630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL501_RS06640	COG3275	phosphorelay sensor kinase activity
AL501_RS06645	COG3279	Response regulator of the LytR AlgR family
AL501_RS06655	COG1380	Effector of murein hydrolase LrgA
AL501_RS06660	COG1346	cytolysis
AL501_RS06700	COG1174	glycine betaine transport
AL501_RS06720	COG1063	alcohol dehydrogenase
AL501_RS06725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AL501_RS06730	COG2272	Belongs to the type-B carboxylesterase lipase family
AL501_RS06735	COG2814	Major facilitator Superfamily
AL501_RS06745	COG0745	RESPONSE REGULATOR receiver
AL501_RS06750	COG2205	protein histidine kinase activity
AL501_RS06755	COG0390	transport system, permease component
AL501_RS06760	COG4619	ABC transporter
AL501_RS06775	COG0069	glutamate synthase activity
AL501_RS06795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL501_RS06800	COG3639	organic phosphonate transmembrane transporter activity
AL501_RS06820	COG1363	Peptidase, m42
AL501_RS06825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL501_RS06835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL501_RS06840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL501_RS06845	COG4221	oxidoreductase activity
AL501_RS06865	COG0438	transferase activity, transferring glycosyl groups
AL501_RS06870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL501_RS06880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL501_RS06885	COG2610	gluconate transmembrane transporter activity
AL501_RS06890	COG1070	Carbohydrate kinase
AL501_RS06895	COG1802	Transcriptional regulator
AL501_RS06910	COG2357	RelA SpoT domain protein
AL501_RS06915	COG4876	unkown
AL501_RS06930	COG2271	Major facilitator Superfamily
AL501_RS06950	COG2022	thiamine diphosphate biosynthetic process
AL501_RS06960	COG0586	Pfam SNARE associated Golgi protein
AL501_RS06965	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AL501_RS06975	COG3949	Membrane
AL501_RS06980	COG0400	carboxylic ester hydrolase activity
AL501_RS06985	COG0346	lactoylglutathione lyase activity
AL501_RS06990	COG0346	lactoylglutathione lyase activity
AL501_RS06995	COG1846	Transcriptional regulator
AL501_RS07015	COG2388	GCN5-related N-acetyl-transferase
AL501_RS07020	COG2514	catechol 2,3-dioxygenase activity
AL501_RS07025	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07035	COG0778	Nitroreductase
AL501_RS07040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS07045	COG0561	phosphatase activity
AL501_RS07055	COG3764	Sortase (surface protein transpeptidase)
AL501_RS07065	COG1760	l-serine dehydratase
AL501_RS07070	COG1760	l-serine dehydratase
AL501_RS07080	COG1070	Carbohydrate kinase
AL501_RS07100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL501_RS07110	COG0657	acetylesterase activity
AL501_RS07115	COG0039	L-malate dehydrogenase activity
AL501_RS07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS07135	COG0028	Belongs to the TPP enzyme family
AL501_RS07140	COG1346	cytolysis
AL501_RS07145	COG1380	Effector of murein hydrolase LrgA
AL501_RS07150	COG0583	DNA-binding transcription factor activity
AL501_RS07160	COG1388	LysM domain
AL501_RS07160	COG3942	CHAP domain
AL501_RS07175	COG3425	synthase
AL501_RS07185	COG1131	(ABC) transporter
AL501_RS07210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL501_RS07215	COG0598	Magnesium transport protein CorA
AL501_RS07225	COG2409	Drug exporters of the RND superfamily
AL501_RS07240	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL501_RS07250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS07255	COG0110	maltose O-acetyltransferase activity
AL501_RS07265	COG2217	Heavy metal translocating P-type atpase
AL501_RS07270	COG2608	mercury ion transmembrane transporter activity
AL501_RS07285	COG0436	Aminotransferase
AL501_RS07305	COG3189	MarR family transcriptional regulator
AL501_RS07315	COG1113	amino acid transport
AL501_RS07325	COG2814	Major facilitator Superfamily
AL501_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS07380	COG3001	Fructosamine kinase
AL501_RS07385	COG0167	dihydroorotate dehydrogenase activity
AL501_RS07405	COG1620	l-lactate permease
AL501_RS07410	COG3527	Alpha-acetolactate decarboxylase
AL501_RS07415	COG0028	Belongs to the TPP enzyme family
AL501_RS07420	COG0583	DNA-binding transcription factor activity
AL501_RS07425	COG0531	amino acid
AL501_RS07435	COG1215	transferase activity, transferring glycosyl groups
AL501_RS07435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS07445	COG0463	Glycosyl transferase, family 2
AL501_RS07455	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS07470	COG3588	fructose-bisphosphate aldolase
AL501_RS07485	COG0583	DNA-binding transcription factor activity
AL501_RS07495	COG2723	6-phospho-beta-galactosidase activity
AL501_RS07500	COG2190	(PTS) system
AL501_RS07500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS07500	COG1263	PTS System
AL501_RS07505	COG2188	Transcriptional regulator
AL501_RS07515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL501_RS07520	COG0574	Belongs to the PEP-utilizing enzyme family
AL501_RS07520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL501_RS07525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL501_RS07540	COG1473	amidohydrolase
AL501_RS07545	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL501_RS07550	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07555	COG1510	regulation of RNA biosynthetic process
AL501_RS07560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL501_RS07565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL501_RS07570	COG0602	queuosine metabolic process
AL501_RS07575	COG1328	CTP reductase activity
AL501_RS07590	COG0529	Catalyzes the synthesis of activated sulfate
AL501_RS07595	COG2046	Belongs to the sulfate adenylyltransferase family
AL501_RS07600	COG0730	response to heat
AL501_RS07615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL501_RS07620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL501_RS07625	COG0175	sulfate reduction
AL501_RS07630	COG3266	domain, Protein
AL501_RS07630	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL501_RS07630	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL501_RS07630	COG4932	domain protein
AL501_RS07630	COG4932	domain protein
AL501_RS07630	COG3266	domain, Protein
AL501_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS07670	COG1136	(ABC) transporter
AL501_RS07675	COG2205	protein histidine kinase activity
AL501_RS07680	COG0745	RESPONSE REGULATOR receiver
AL501_RS07695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL501_RS07700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL501_RS07705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL501_RS07715	COG0297	glycogen (starch) synthase activity
AL501_RS07740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL501_RS07775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL501_RS07780	COG4195	phage-related replication protein
AL501_RS07785	COG2843	Capsule synthesis protein
AL501_RS07795	COG2235	arginine
AL501_RS07820	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL501_RS07820	COG3942	CHAP domain
AL501_RS07850	COG1476	TRANSCRIPTIONal
AL501_RS07860	COG1122	ATPase activity
AL501_RS07870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL501_RS07885	COG3386	PFAM SMP-30 Gluconolaconase
AL501_RS07890	COG1054	Belongs to the UPF0176 family
AL501_RS07895	COG3037	sugar-specific permease SgaT UlaA
AL501_RS07905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS07910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS07910	COG3711	transcriptional antiterminator
AL501_RS07915	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL501_RS07935	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL501_RS07940	COG1266	CAAX protease self-immunity
AL501_RS07970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS07975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL501_RS07980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL501_RS07995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL501_RS08000	COG0363	glucosamine-6-phosphate deaminase activity
AL501_RS08010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL501_RS08030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL501_RS08085	COG0531	amino acid
AL501_RS08095	COG0706	membrane insertase activity
AL501_RS08120	COG1482	cell wall glycoprotein biosynthetic process
AL501_RS08125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS08125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS08125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08130	COG3711	transcriptional antiterminator
AL501_RS08130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08150	COG1695	Transcriptional regulator
AL501_RS08160	COG0022	dehydrogenase e1 component
AL501_RS08165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL501_RS08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS08180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL501_RS08195	COG3976	FMN-binding domain protein
AL501_RS08195	COG1053	succinate dehydrogenase
AL501_RS08195	COG0431	NADPH-dependent FMN reductase
AL501_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS08225	COG2190	(PTS) system
AL501_RS08225	COG1263	PTS System
AL501_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08255	COG2814	Major facilitator Superfamily
AL501_RS08265	COG1288	antiporter activity
AL501_RS08270	COG2353	YceI-like domain
AL501_RS08280	COG1131	(ABC) transporter
AL501_RS08295	COG3961	Belongs to the TPP enzyme family
AL501_RS08300	COG1124	(ABC) transporter
AL501_RS08305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS08315	COG0601	transmembrane transport
AL501_RS08320	COG0747	negative chemotaxis
AL501_RS08325	COG2264	protein methyltransferase activity
AL501_RS08350	COG1131	(ABC) transporter
AL501_RS08365	COG2814	Major facilitator Superfamily
AL501_RS08385	COG1233	COG1233 Phytoene dehydrogenase and related
AL501_RS08395	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AL501_RS08400	COG2311	Membrane
AL501_RS08415	COG1278	Cold shock
AL501_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08435	COG1131	(ABC) transporter
AL501_RS08450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL501_RS08470	COG2409	Drug exporters of the RND superfamily
AL501_RS08470	COG1033	growth of symbiont in host cell
AL501_RS08510	COG0657	acetylesterase activity
AL501_RS08515	COG0505	Belongs to the CarA family
AL501_RS08525	COG0531	amino acid
AL501_RS08530	COG0693	protein deglycase activity
AL501_RS08545	COG1124	(ABC) transporter
AL501_RS08550	COG0444	Belongs to the ABC transporter superfamily
AL501_RS08560	COG0601	transmembrane transport
AL501_RS08575	COG2814	Major facilitator Superfamily
AL501_RS08580	COG0561	phosphatase activity
AL501_RS08585	COG0464	growth
AL501_RS08595	COG1114	Component of the transport system for branched-chain amino acids
AL501_RS08605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL501_RS08610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL501_RS08615	COG1177	transmembrane transport
AL501_RS08620	COG1840	ABC-type Fe3 transport system, periplasmic component
AL501_RS08625	COG3842	ATPase activity
AL501_RS08630	COG0583	DNA-binding transcription factor activity
AL501_RS08665	COG5002	protein histidine kinase activity
AL501_RS08675	COG1349	DNA-binding transcription factor activity
AL501_RS08680	COG0534	Mate efflux family protein
AL501_RS08690	COG0395	ABC-type sugar transport system, permease component
AL501_RS08700	COG4209	transmembrane transport
AL501_RS08705	COG3842	ATPase activity
AL501_RS08715	COG1846	Transcriptional regulator
AL501_RS08725	COG2808	Putative FMN-binding domain
AL501_RS08730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS08735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS08745	COG3942	CHAP domain
AL501_RS08745	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL501_RS08755	COG4509	Sortase family
AL501_RS08790	COG1129	ABC transporter
AL501_RS08815	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL501_RS08820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL501_RS08830	COG2205	protein histidine kinase activity
AL501_RS08835	COG0745	RESPONSE REGULATOR receiver
AL501_RS08845	COG3716	PTS system mannose fructose sorbose family IID component
AL501_RS08850	COG3715	PTS system
AL501_RS08855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS08860	COG3684	Belongs to the aldolase LacD family
AL501_RS08865	COG2222	sugar isomerase
AL501_RS08870	COG2188	Transcriptional regulator
AL501_RS08935	COG1131	(ABC) transporter
AL501_RS08950	COG0745	RESPONSE REGULATOR receiver
AL501_RS08990	COG1129	ABC transporter
AL501_RS09005	COG1073	alpha beta
AL501_RS09035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL501_RS09045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL501_RS09055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL501_RS09060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL501_RS09095	COG4863	YycH protein
AL501_RS09100	COG5002	protein histidine kinase activity
AL501_RS09105	COG0745	RESPONSE REGULATOR receiver
AL501_RS09120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL501_RS09125	COG0305	Participates in initiation and elongation during chromosome replication
AL501_RS09130	COG0359	binds to the 23S rRNA
AL501_RS09135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AL501_RS09145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL501_RS09155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AL501_RS09165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL501_RS09170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL501_RS09175	COG0187	DNA topoisomerase II activity
AL501_RS09180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL501_RS09185	COG2501	S4 domain
AL501_RS09190	COG0592	DNA-directed DNA polymerase activity
AL501_RS09195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL501_RS09205	COG0594	ribonuclease P activity
AL501_RS09210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL501_RS09215	COG0445	tRNA wobble uridine modification
AL501_RS09225	COG1475	DNA binding
AL501_RS09245	COG1063	alcohol dehydrogenase
AL501_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS09270	COG1396	sequence-specific DNA binding
AL501_RS09280	COG0577	efflux transmembrane transporter activity
AL501_RS09285	COG1136	(ABC) transporter
AL501_RS09300	COG2271	Major facilitator Superfamily
AL501_RS09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL501_RS09310	COG3878	Protein conserved in bacteria
AL501_RS09335	COG0745	RESPONSE REGULATOR receiver
AL501_RS09350	COG2205	protein histidine kinase activity
AL501_RS09370	COG1136	(ABC) transporter
AL501_RS09375	COG0577	efflux transmembrane transporter activity
AL501_RS09400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL501_RS09405	COG0646	methionine synthase
AL501_RS09405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL501_RS09410	COG0626	cystathionine gamma-synthase activity
AL501_RS09415	COG0626	cystathionine gamma-synthase activity
AL501_RS09420	COG1475	DNA binding
AL501_RS09425	COG0668	transmembrane transport
AL501_RS09430	COG4481	Protein conserved in bacteria
AL501_RS09435	COG0012	GTP binding
AL501_RS09450	COG0360	Binds together with S18 to 16S ribosomal RNA
AL501_RS09460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL501_RS09495	COG0588	phosphoglycerate mutase activity
AL501_RS09510	COG3634	alkyl hydroperoxide reductase activity
AL501_RS09515	COG0450	alkyl hydroperoxide reductase
AL501_RS09525	COG0778	Nitroreductase
AL501_RS09530	COG1823	symporter activity
AL501_RS09550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL501_RS09555	COG2233	PERMEase
AL501_RS09560	COG0516	GMP reductase activity
AL501_RS09560	COG0517	IMP dehydrogenase activity
AL501_RS09565	COG0519	Catalyzes the synthesis of GMP from XMP
AL501_RS09565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL501_RS09585	COG0523	cobalamin synthesis protein
AL501_RS09595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL501_RS09600	COG3002	Belongs to the UPF0753 family
AL501_RS09605	COG5609	conserved protein (DUF2294)
AL501_RS09625	COG0733	neurotransmitter:sodium symporter activity
AL501_RS09635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL501_RS09640	COG0626	cystathionine gamma-synthase activity
AL501_RS09645	COG1132	(ABC) transporter
AL501_RS09645	COG2375	cellular response to nickel ion
AL501_RS09650	COG1132	(ABC) transporter
AL501_RS09655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS09660	COG2011	ABC-type metal ion transport system permease component
AL501_RS09665	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS09700	COG0583	DNA-binding transcription factor activity
AL501_RS09705	COG0070	glutamate synthase
AL501_RS09705	COG0069	glutamate synthase activity
AL501_RS09705	COG0067	glutamate synthase
AL501_RS09710	COG0493	'glutamate synthase
AL501_RS09725	COG0366	Alpha amylase catalytic
AL501_RS09730	COG2188	Transcriptional regulator
AL501_RS09745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL501_RS09755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL501_RS09795	COG1982	Orn Lys Arg decarboxylase major
AL501_RS09800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL501_RS09805	COG3870	Protein conserved in bacteria
AL501_RS09810	COG0470	DNA polymerase III
AL501_RS09815	COG1774	PSP1 C-terminal conserved region
AL501_RS09825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL501_RS09835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL501_RS09840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS09840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS09845	COG0084	hydrolase, TatD family'
AL501_RS09850	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL501_RS09855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL501_RS09860	COG4466	Protein conserved in bacteria
AL501_RS09865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL501_RS09870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL501_RS09875	COG0251	oxidation-reduction process
AL501_RS09885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL501_RS09890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL501_RS09900	COG0193	aminoacyl-tRNA hydrolase activity
AL501_RS09905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL501_RS09910	COG2244	polysaccharide biosynthetic process
AL501_RS09915	COG3956	TIGRFAM MazG family protein
AL501_RS09920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL501_RS09930	COG1098	S1 RNA binding domain
AL501_RS09945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL501_RS09955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL501_RS09965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL501_RS09970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL501_RS09975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL501_RS10060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL501_RS10065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AL501_RS10070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL501_RS10075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS10080	COG4463	regulation of RNA biosynthetic process
AL501_RS10085	COG3880	PFAM UvrB UvrC protein
AL501_RS10090	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AL501_RS10095	COG0542	response to heat
AL501_RS10100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL501_RS10105	COG4956	integral membrane protein (PIN domain superfamily)
AL501_RS10110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL501_RS10115	COG1045	serine acetyltransferase
AL501_RS10120	COG0215	cysteine-tRNA ligase activity
AL501_RS10125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AL501_RS10130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL501_RS10135	COG3688	RNA-binding protein containing a PIN domain
AL501_RS10145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL501_RS10150	COG0250	Participates in transcription elongation, termination and antitermination
AL501_RS10160	COG0081	regulation of translation
AL501_RS10165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL501_RS10170	COG0222	ribosome binding
AL501_RS10175	COG2813	Specifically methylates the guanine in position
AL501_RS10180	COG0085	RNA polymerase activity
AL501_RS10185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL501_RS10195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL501_RS10210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL501_RS10215	COG1473	amidohydrolase
AL501_RS10240	COG1279	arginine transmembrane transporter activity
AL501_RS10250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL501_RS10255	COG0531	amino acid
AL501_RS10275	COG1428	Deoxynucleoside kinase
AL501_RS10280	COG1428	Deoxynucleoside kinase
AL501_RS10290	COG0561	phosphatase activity
AL501_RS10315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS10325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL501_RS10335	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL501_RS10340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL501_RS10370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL501_RS10380	COG2363	Small membrane protein
AL501_RS10410	COG3253	May function as heme-dependent peroxidase
AL501_RS10420	COG0095	Lipoate-protein ligase
AL501_RS10440	COG4844	belongs to the
AL501_RS10445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS10450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AL501_RS10480	COG3561	AntA/AntB antirepressor
AL501_RS10535	COG1484	DNA-dependent DNA replication
AL501_RS10675	COG5434	Belongs to the glycosyl hydrolase 28 family
AL501_RS10715	COG1388	LysM domain
AL501_RS10715	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL501_RS10735	COG0667	Aldo Keto reductase
AL501_RS10740	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL501_RS10750	COG1078	dGTPase activity
AL501_RS10760	COG1064	alcohol dehydrogenase
AL501_RS10780	COG0018	arginyl-trna synthetase
AL501_RS10800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS10805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS10860	COG4974	Belongs to the 'phage' integrase family
AL501_RS10865	COG2111	Na H antiporter
AL501_RS10865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL501_RS10870	COG2111	Na H antiporter
AL501_RS10875	COG1006	Multisubunit Na H antiporter MnhC subunit
AL501_RS10880	COG0651	ATP synthesis coupled electron transport
AL501_RS10885	COG1863	multisubunit Na H antiporter MnhE subunit
AL501_RS10890	COG2212	antiporter activity
AL501_RS10895	COG1320	monovalent cation:proton antiporter activity
AL501_RS10905	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL501_RS10910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL501_RS10915	COG1121	(ABC) transporter
AL501_RS10920	COG1321	iron dependent repressor
AL501_RS10930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL501_RS10945	COG1134	teichoic acid transport
AL501_RS10950	COG1682	transport, permease protein
AL501_RS10960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS10965	COG1215	transferase activity, transferring glycosyl groups
AL501_RS10970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL501_RS10975	COG1686	Belongs to the peptidase S11 family
AL501_RS10980	COG1132	(ABC) transporter
AL501_RS10985	COG0438	transferase activity, transferring glycosyl groups
AL501_RS10990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS10990	COG0463	Glycosyl transferase, family 2
AL501_RS11000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS11010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL501_RS11015	COG1120	ATPase activity
AL501_RS11020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11030	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AL501_RS11040	COG3949	Membrane
AL501_RS11045	COG0657	acetylesterase activity
AL501_RS11055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL501_RS11060	COG0745	RESPONSE REGULATOR receiver
AL501_RS11065	COG2205	protein histidine kinase activity
AL501_RS11070	COG1136	(ABC) transporter
AL501_RS11075	COG0577	efflux transmembrane transporter activity
AL501_RS11080	COG1392	Phosphate transport regulator
AL501_RS11085	COG0306	phosphate transporter
AL501_RS11090	COG1388	LysM domain
AL501_RS11090	COG3942	CHAP domain
AL501_RS11110	COG0217	transcriptional regulatory protein
AL501_RS11130	COG0583	DNA-binding transcription factor activity
AL501_RS11135	COG2814	Major facilitator Superfamily
AL501_RS11140	COG2839	Protein conserved in bacteria
AL501_RS11170	COG1611	Belongs to the LOG family
AL501_RS11175	COG1671	Belongs to the UPF0178 family
AL501_RS11185	COG1968	undecaprenyl-diphosphatase activity
AL501_RS11195	COG0523	cobalamin synthesis protein
AL501_RS11205	COG0039	L-malate dehydrogenase activity
AL501_RS11210	COG0471	metal ion transport
AL501_RS11215	COG0415	Belongs to the DNA photolyase family
AL501_RS11235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL501_RS11240	COG1349	DNA-binding transcription factor activity
AL501_RS11245	COG1105	Belongs to the carbohydrate kinase PfkB family
AL501_RS11250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS11250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS11250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS11255	COG1253	flavin adenine dinucleotide binding
AL501_RS11260	COG0656	L-ascorbic acid biosynthetic process
AL501_RS11265	COG0463	Glycosyl transferase, family 2
AL501_RS11280	COG0720	synthase
AL501_RS11290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL501_RS11290	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS11295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL501_RS11295	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS11305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL501_RS11315	COG1368	sulfuric ester hydrolase activity
AL501_RS11325	COG0488	(ABC) transporter
AL501_RS11330	COG0514	ATP-dependent DNA helicase (RecQ)
AL501_RS11340	COG1174	glycine betaine transport
AL501_RS11345	COG3104	oligopeptide transport
AL501_RS11350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL501_RS11360	COG1597	lipid kinase activity
AL501_RS11365	COG3104	oligopeptide transport
AL501_RS11370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL501_RS11380	COG1780	Probably involved in ribonucleotide reductase function
AL501_RS11385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL501_RS11390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL501_RS11395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11400	COG4605	iron ion homeostasis
AL501_RS11405	COG4604	ABC transporter, ATP-binding protein
AL501_RS11410	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS11415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11420	COG4605	iron ion homeostasis
AL501_RS11425	COG4604	ABC transporter, ATP-binding protein
AL501_RS11430	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS11440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL501_RS11460	COG1929	Belongs to the glycerate kinase type-1 family
AL501_RS11465	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL501_RS11480	COG2199	diguanylate cyclase activity
AL501_RS11485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL501_RS11490	COG1739	Uncharacterized protein family UPF0029
AL501_RS11500	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AL501_RS11505	COG1040	competence protein
AL501_RS11510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL501_RS11520	COG0653	protein targeting
AL501_RS11525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL501_RS11530	COG3942	CHAP domain
AL501_RS11530	COG1388	LysM domain
AL501_RS11550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL501_RS11555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL501_RS11560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL501_RS11575	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS11580	COG1660	Displays ATPase and GTPase activities
AL501_RS11585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL501_RS11590	COG1481	regulation of sporulation
AL501_RS11600	COG0740	serine-type endopeptidase activity
AL501_RS11605	COG1090	epimerase
AL501_RS11625	COG0126	phosphoglycerate kinase activity
AL501_RS11630	COG0149	triose-phosphate isomerase activity
AL501_RS11635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL501_RS11640	COG0148	phosphopyruvate hydratase activity
AL501_RS11650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL501_RS11655	COG1647	Serine aminopeptidase, S33
AL501_RS11660	COG0557	exoribonuclease II activity
AL501_RS11735	COG1611	Belongs to the LOG family
AL501_RS11745	COG0346	lactoylglutathione lyase activity
AL501_RS11750	COG2259	Doxx family
AL501_RS11765	COG4195	phage-related replication protein
AL501_RS11795	COG0588	phosphoglycerate mutase activity
AL501_RS11805	COG1764	response to oxidative stress
AL501_RS11810	COG0710	3-dehydroquinate dehydratase activity
AL501_RS11820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS11825	COG1393	Belongs to the ArsC family
AL501_RS11830	COG0509	glycine decarboxylation via glycine cleavage system
AL501_RS11835	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL501_RS11845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS11850	COG2011	ABC-type metal ion transport system permease component
AL501_RS11855	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS11875	COG0396	ATPase activity
AL501_RS11880	COG0719	Fe-S assembly protein
AL501_RS11890	COG0822	iron-sulfur transferase activity
AL501_RS11895	COG0719	Fe-S assembly protein
AL501_RS11915	COG3942	CHAP domain
AL501_RS11915	COG1388	LysM domain
AL501_RS12060	COG1253	flavin adenine dinucleotide binding
AL501_RS12065	COG2070	2-Nitropropane dioxygenase
AL501_RS12070	COG1801	Protein of unknown function DUF72
AL501_RS12075	COG0730	response to heat
AL501_RS12080	COG0737	Belongs to the 5'-nucleotidase family
AL501_RS12085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL501_RS12090	COG4470	Protein conserved in bacteria
AL501_RS12100	COG2445	Protein of unknown function DUF86
AL501_RS12105	COG0647	UMP catabolic process
AL501_RS12110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS12120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL501_RS12125	COG1696	Membrane protein involved in D-alanine export
AL501_RS12130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL501_RS12135	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AL501_RS12140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL501_RS12145	COG4837	Protein of unknown function (DUF1462)
AL501_RS12150	COG1252	NADH dehydrogenase
AL501_RS12155	COG4844	belongs to the
AL501_RS12160	COG0316	Belongs to the HesB IscA family
AL501_RS12175	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL501_RS12180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL501_RS12180	COG3433	isochorismatase activity
AL501_RS12180	COG2226	methyltransferase
AL501_RS12210	COG1129	ABC transporter
AL501_RS12220	COG1132	(ABC) transporter
AL501_RS12230	COG1252	NADH dehydrogenase
AL501_RS12235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL501_RS12240	COG2056	Na+-H+ antiporter family
AL501_RS12245	COG2050	protein possibly involved in aromatic compounds catabolism
AL501_RS12255	COG1320	monovalent cation:proton antiporter activity
AL501_RS12260	COG2212	antiporter activity
AL501_RS12265	COG1863	multisubunit Na H antiporter MnhE subunit
AL501_RS12270	COG0651	ATP synthesis coupled electron transport
AL501_RS12275	COG1006	Multisubunit Na H antiporter MnhC subunit
AL501_RS12280	COG2111	Na H antiporter