locus-tag	class	description
AL501_RS00015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL501_RS00020	COG1098	S1 RNA binding domain
AL501_RS00025	COG1902	pentaerythritol trinitrate reductase activity
AL501_RS00055	COG0137	argininosuccinate synthase activity
AL501_RS00060	COG0166	Belongs to the GPI family
AL501_RS00065	COG0398	Pfam SNARE associated Golgi protein
AL501_RS00085	COG1074	ATP-dependent DNA helicase activity
AL501_RS00100	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL501_RS00105	COG0561	phosphatase activity
AL501_RS00115	COG0542	response to heat
AL501_RS00125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL501_RS00140	COG0601	transmembrane transport
AL501_RS00145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL501_RS00150	COG0444	Belongs to the ABC transporter superfamily
AL501_RS00155	COG4608	Belongs to the ABC transporter superfamily
AL501_RS00160	COG4166	transmembrane transport
AL501_RS00165	COG2226	methyltransferase
AL501_RS00170	COG0180	Tryptophanyl-tRNA synthetase
AL501_RS00175	COG1393	Belongs to the ArsC family
AL501_RS00190	COG1164	Oligoendopeptidase f
AL501_RS00200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL501_RS00205	COG2346	COG2346, Truncated hemoglobins
AL501_RS00220	COG2357	RelA SpoT domain protein
AL501_RS00230	COG0564	pseudouridine synthase activity
AL501_RS00235	COG2239	Acts as a magnesium transporter
AL501_RS00240	COG0475	glutathione-regulated potassium exporter activity
AL501_RS00240	COG0569	domain protein
AL501_RS00250	COG0628	permease
AL501_RS00260	COG4221	oxidoreductase activity
AL501_RS00270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL501_RS00275	COG2814	Major facilitator Superfamily
AL501_RS00280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL501_RS00285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL501_RS00300	COG0861	Integral membrane protein TerC family
AL501_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS00305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS00310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL501_RS00315	COG0737	Belongs to the 5'-nucleotidase family
AL501_RS00325	COG4873	Protein conserved in bacteria
AL501_RS00415	COG1575	Belongs to the MenA family. Type 1 subfamily
AL501_RS00420	COG1169	isochorismate synthase
AL501_RS00425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL501_RS00430	COG0596	Alpha beta hydrolase
AL501_RS00435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL501_RS00440	COG0436	Aminotransferase
AL501_RS00445	COG3594	Acyltransferase
AL501_RS00475	COG1316	TRANSCRIPTIONal
AL501_RS00480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL501_RS00490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL501_RS00495	COG1845	cytochrome c oxidase, subunit III
AL501_RS00505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL501_RS00515	COG1017	nitric oxide dioxygenase activity
AL501_RS00515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL501_RS00525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL501_RS00530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL501_RS00535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL501_RS00540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL501_RS00545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL501_RS00550	COG0047	phosphoribosylformylglycinamidine synthase activity
AL501_RS00555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL501_RS00565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL501_RS00575	COG0138	bifunctional purine biosynthesis protein purh
AL501_RS00580	COG0151	Belongs to the GarS family
AL501_RS00585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL501_RS00590	COG4172	Belongs to the ABC transporter superfamily
AL501_RS00605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL501_RS00620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL501_RS00635	COG0569	domain protein
AL501_RS00645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL501_RS00650	COG5503	Protein of unknown function (DUF1447)
AL501_RS00655	COG0242	peptide deformylase activity
AL501_RS00670	COG0022	dehydrogenase e1 component
AL501_RS00685	COG4476	Belongs to the UPF0223 family
AL501_RS00705	COG1177	transmembrane transport
AL501_RS00710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL501_RS00730	COG4493	Belongs to the UPF0637 family
AL501_RS00735	COG0483	inositol monophosphate 1-phosphatase activity
AL501_RS00745	COG1217	gtp-binding protein TYPA
AL501_RS00755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL501_RS00760	COG4838	Belongs to the UPF0358 family
AL501_RS00765	COG0772	Belongs to the SEDS family
AL501_RS00775	COG1612	heme a metabolic process
AL501_RS00780	COG0109	protoheme IX farnesyltransferase activity
AL501_RS00795	COG3679	Belongs to the UPF0342 family
AL501_RS00815	COG0742	ribosomal rna small subunit methyltransferase
AL501_RS00820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL501_RS00825	COG1323	Belongs to the UPF0348 family
AL501_RS00840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL501_RS00845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL501_RS00850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL501_RS00855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS00855	COG0072	phenylalanine-tRNA ligase activity
AL501_RS00865	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL501_RS00870	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL501_RS00880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL501_RS00880	COG1796	DNA polymerase
AL501_RS00885	COG1193	negative regulation of DNA recombination
AL501_RS00890	COG3118	belongs to the thioredoxin family
AL501_RS00895	COG0322	excinuclease ABC activity
AL501_RS00900	COG2009	succinate dehydrogenase
AL501_RS00905	COG1053	succinate dehydrogenase
AL501_RS00910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL501_RS00915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL501_RS00920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL501_RS00930	COG1011	Hydrolase
AL501_RS00940	COG0454	-acetyltransferase
AL501_RS00945	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL501_RS00955	COG0275	rRNA processing
AL501_RS00960	COG4839	cell division protein FtsL
AL501_RS00965	COG0768	penicillin binding
AL501_RS00970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL501_RS00975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL501_RS00980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL501_RS00985	COG0849	cell division
AL501_RS00990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL501_RS00995	COG1496	oxidoreductase activity
AL501_RS01000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL501_RS01005	COG1799	cell septum assembly
AL501_RS01010	COG0762	integral membrane protein
AL501_RS01015	COG2302	S4 RNA-binding domain
AL501_RS01020	COG3599	regulation of cell shape
AL501_RS01025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL501_RS01035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL501_RS01040	COG0564	pseudouridine synthase activity
AL501_RS01045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AL501_RS01050	COG2233	PERMEase
AL501_RS01055	COG0540	Belongs to the ATCase OTCase family
AL501_RS01065	COG0505	Belongs to the CarA family
AL501_RS01075	COG0284	orotidine-5'-phosphate decarboxylase activity
AL501_RS01080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL501_RS01100	COG0194	GDP metabolic process
AL501_RS01105	COG1758	RNA polymerase activity
AL501_RS01110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL501_RS01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL501_RS01125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL501_RS01130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL501_RS01130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL501_RS01140	COG0631	protein serine/threonine phosphatase activity
AL501_RS01155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL501_RS01165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL501_RS01170	COG1302	Protein conserved in bacteria
AL501_RS01175	COG1461	Dihydroxyacetone kinase
AL501_RS01180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL501_RS01185	COG1349	DNA-binding transcription factor activity
AL501_RS01190	COG0416	fatty acid biosynthetic process
AL501_RS01205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL501_RS01210	COG0571	ribonuclease III activity
AL501_RS01215	COG1196	nuclear chromosome segregation
AL501_RS01220	COG0552	protein localization to endoplasmic reticulum
AL501_RS01225	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AL501_RS01230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL501_RS01235	COG0318	PFAM AMP-dependent synthetase and ligase
AL501_RS01240	COG0183	Belongs to the thiolase family
AL501_RS01255	COG0228	four-way junction DNA binding
AL501_RS01260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL501_RS01265	COG0336	Belongs to the RNA methyltransferase TrmD family
AL501_RS01270	COG0335	large ribosomal subunit rRNA binding
AL501_RS01280	COG4485	Bacterial membrane protein, YfhO
AL501_RS01290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL501_RS01295	COG0045	succinate-CoA ligase (ADP-forming) activity
AL501_RS01300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL501_RS01305	COG2348	transferase activity, transferring amino-acyl groups
AL501_RS01315	COG0758	DNA mediated transformation
AL501_RS01320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL501_RS01325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL501_RS01330	COG4974	Belongs to the 'phage' integrase family
AL501_RS01335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL501_RS01340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL501_RS01345	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL501_RS01350	COG0052	Belongs to the universal ribosomal protein uS2 family
AL501_RS01355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL501_RS01360	COG0528	UMP kinase activity
AL501_RS01365	COG0233	cytoplasmic translational termination
AL501_RS01370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL501_RS01375	COG4589	Belongs to the CDS family
AL501_RS01390	COG0442	prolyl-tRNA aminoacylation
AL501_RS01395	COG2176	DNA-directed DNA polymerase activity
AL501_RS01400	COG0779	Required for maturation of 30S ribosomal subunits
AL501_RS01405	COG0195	Participates in both transcription termination and antitermination
AL501_RS01410	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AL501_RS01420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL501_RS01425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL501_RS01435	COG0196	riboflavin kinase activity
AL501_RS01445	COG1185	polyribonucleotide nucleotidyltransferase activity
AL501_RS01455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL501_RS01460	COG1674	ftsk spoiiie
AL501_RS01465	COG2188	Transcriptional regulator
AL501_RS01470	COG0612	Peptidase, M16
AL501_RS01475	COG0612	Peptidase, M16
AL501_RS01480	COG0300	oxidoreductase activity
AL501_RS01500	COG1058	Belongs to the CinA family
AL501_RS01500	COG1546	Belongs to the CinA family
AL501_RS01505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL501_RS01510	COG1418	mRNA catabolic process
AL501_RS01520	COG1692	metallophosphoesterase
AL501_RS01525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL501_RS01525	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL501_RS01530	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL501_RS01535	COG4195	phage-related replication protein
AL501_RS01550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL501_RS01565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL501_RS01570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL501_RS01580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL501_RS01585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL501_RS01590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL501_RS01600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL501_RS01605	COG1923	regulation of RNA biosynthetic process
AL501_RS01615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL501_RS01620	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AL501_RS01625	COG0789	Transcriptional regulator
AL501_RS01640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL501_RS01645	COG1131	(ABC) transporter
AL501_RS01655	COG4585	Histidine kinase
AL501_RS01655	COG2203	Gaf domain
AL501_RS01660	COG2197	response regulator
AL501_RS01675	COG1525	nuclease
AL501_RS01690	COG0527	aspartate kinase activity
AL501_RS01695	COG0460	homoserine dehydrogenase
AL501_RS01700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL501_RS01705	COG0083	homoserine kinase activity
AL501_RS01720	COG0833	amino acid
AL501_RS01735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL501_RS01745	COG2340	Cysteine-rich secretory protein family
AL501_RS01750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL501_RS01760	COG4224	UPF0291 protein
AL501_RS01765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL501_RS01770	COG3763	UPF0154 protein
AL501_RS01775	COG4846	Membrane protein involved in cytochrome C biogenesis
AL501_RS01790	COG1970	mechanosensitive ion channel activity
AL501_RS01795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL501_RS01800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL501_RS01810	COG4841	protein insertion into membrane
AL501_RS01815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL501_RS01820	COG0187	DNA topoisomerase II activity
AL501_RS01825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL501_RS01830	COG1115	amino acid carrier protein
AL501_RS01835	COG0628	permease
AL501_RS01840	COG0392	lysyltransferase activity
AL501_RS01840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL501_RS01855	COG1942	4-Oxalocrotonate Tautomerase
AL501_RS01860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL501_RS01865	COG0287	Prephenate dehydrogenase
AL501_RS01885	COG3623	hexulose-6-phosphate isomerase
AL501_RS01895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS01910	COG1363	Peptidase, m42
AL501_RS01915	COG0328	RNA-DNA hybrid ribonuclease activity
AL501_RS01920	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL501_RS01930	COG1413	lyase activity
AL501_RS01960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL501_RS01970	COG4479	Belongs to the UPF0346 family
AL501_RS01975	COG0793	Belongs to the peptidase S41A family
AL501_RS01985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL501_RS01990	COG0671	phosphoesterase, PA-phosphatase related
AL501_RS01995	COG0745	RESPONSE REGULATOR receiver
AL501_RS02000	COG5002	protein histidine kinase activity
AL501_RS02005	COG0567	Dehydrogenase, E1 component
AL501_RS02025	COG0714	Associated with various cellular activities
AL501_RS02030	COG4548	von Willebrand factor, type A
AL501_RS02035	COG1114	Component of the transport system for branched-chain amino acids
AL501_RS02040	COG3853	Toxic anion resistance protein (TelA)
AL501_RS02050	COG1254	Belongs to the acylphosphatase family
AL501_RS02060	COG1278	Cold shock
AL501_RS02085	COG1473	amidohydrolase
AL501_RS02090	COG2171	N-acyltransferase activity
AL501_RS02095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL501_RS02100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL501_RS02105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL501_RS02110	COG0527	aspartate kinase activity
AL501_RS02115	COG0488	(ABC) transporter
AL501_RS02120	COG2996	Protein conserved in bacteria
AL501_RS02125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL501_RS02130	COG0573	inorganic phosphate transmembrane transporter activity
AL501_RS02135	COG0581	inorganic phosphate transmembrane transporter activity
AL501_RS02140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL501_RS02150	COG1164	Oligoendopeptidase f
AL501_RS02165	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS02170	COG0561	phosphatase activity
AL501_RS02180	COG2348	transferase activity, transferring amino-acyl groups
AL501_RS02195	COG0135	phosphoribosylanthranilate isomerase activity
AL501_RS02200	COG0134	indole-3-glycerol-phosphate synthase activity
AL501_RS02205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL501_RS02210	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS02215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL501_RS02220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS02225	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AL501_RS02235	COG0116	Belongs to the methyltransferase superfamily
AL501_RS02245	COG3599	regulation of cell shape
AL501_RS02250	COG4474	Belongs to the UPF0398 family
AL501_RS02265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL501_RS02265	COG4499	WXG100 protein secretion system (Wss), protein YukC
AL501_RS02275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL501_RS02280	COG3935	DnaD domain protein
AL501_RS02285	COG0017	Asparaginyl-tRNA synthetase
AL501_RS02290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL501_RS02290	COG1199	ATP-dependent helicase activity
AL501_RS02295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL501_RS02295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL501_RS02300	COG0617	tRNA 3'-terminal CCA addition
AL501_RS02305	COG0438	transferase activity, transferring glycosyl groups
AL501_RS02310	COG1694	Mazg nucleotide pyrophosphohydrolase
AL501_RS02315	COG2738	Putative neutral zinc metallopeptidase
AL501_RS02340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL501_RS02345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL501_RS02355	COG0142	geranyltranstransferase activity
AL501_RS02360	COG2226	methyltransferase
AL501_RS02375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL501_RS02385	COG0539	negative regulation of cytoplasmic translation
AL501_RS02405	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS02415	COG1388	LysM domain
AL501_RS02420	COG0514	ATP-dependent DNA helicase (RecQ)
AL501_RS02430	COG1141	Ferredoxin
AL501_RS02445	COG0745	RESPONSE REGULATOR receiver
AL501_RS02450	COG1187	pseudouridine synthase activity
AL501_RS02455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL501_RS02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL501_RS02470	COG4974	Belongs to the 'phage' integrase family
AL501_RS02475	COG0735	belongs to the Fur family
AL501_RS02480	COG0494	nUDIX hydrolase
AL501_RS02485	COG0667	Aldo Keto reductase
AL501_RS02490	COG0300	oxidoreductase activity
AL501_RS02495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL501_RS02505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL501_RS02515	COG0366	Alpha amylase catalytic
AL501_RS02520	COG1609	Transcriptional regulator
AL501_RS02530	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL501_RS02535	COG4129	membrane
AL501_RS02545	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL501_RS02550	COG0022	dehydrogenase e1 component
AL501_RS02555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL501_RS02560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS02565	COG0280	phosphate acetyltransferase
AL501_RS02570	COG0497	DNA recombination
AL501_RS02575	COG1438	arginine binding
AL501_RS02595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL501_RS02600	COG1302	Protein conserved in bacteria
AL501_RS02605	COG0439	Biotin carboxylase
AL501_RS02610	COG0511	ligase activity, forming carbon-carbon bonds
AL501_RS02615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL501_RS02620	COG0006	proline dipeptidase activity
AL501_RS02640	COG0095	Lipoate-protein ligase
AL501_RS02645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL501_RS02650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL501_RS02655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL501_RS02660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL501_RS02665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL501_RS02690	COG4537	Required for transformation and DNA binding
AL501_RS02695	COG1459	type II secretion system
AL501_RS02700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL501_RS02705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL501_RS02710	COG0011	TIGRFAM Protein of
AL501_RS02715	COG1940	carbohydrate kinase activity
AL501_RS02720	COG4483	Protein conserved in bacteria
AL501_RS02725	COG0457	Tetratricopeptide repeat
AL501_RS02725	COG0705	Rhomboid family
AL501_RS02730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL501_RS02735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL501_RS02740	COG0768	penicillin binding
AL501_RS02745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL501_RS02755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL501_RS02760	COG1121	(ABC) transporter
AL501_RS02765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL501_RS02770	COG0513	Belongs to the DEAD box helicase family
AL501_RS02780	COG2384	SAM-dependent methyltransferase
AL501_RS02795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL501_RS02800	COG0517	IMP dehydrogenase activity
AL501_RS02805	COG0423	glycine-tRNA ligase activity
AL501_RS02810	COG1381	Involved in DNA repair and RecF pathway recombination
AL501_RS02815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL501_RS02820	COG0295	cytidine deaminase activity
AL501_RS02825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL501_RS02830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL501_RS02835	COG1702	phosphate starvation-inducible protein PhoH
AL501_RS02845	COG4864	UPF0365 protein
AL501_RS02850	COG1030	water channel activity
AL501_RS02860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL501_RS02865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL501_RS02870	COG2264	protein methyltransferase activity
AL501_RS02875	COG0484	heat shock protein binding
AL501_RS02880	COG0443	Heat shock 70 kDa protein
AL501_RS02885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL501_RS02895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL501_RS02900	COG0481	GTPase activity
AL501_RS02905	COG0268	Binds directly to 16S ribosomal RNA
AL501_RS02910	COG1466	dna polymerase III delta subunit
AL501_RS02915	COG0658	competence protein
AL501_RS02915	COG2333	competence protein COMEC
AL501_RS02920	COG2131	deaminase
AL501_RS02925	COG1596	polysaccharide export
AL501_RS02925	COG1555	photosystem II stabilization
AL501_RS02930	COG2226	methyltransferase
AL501_RS02935	COG0799	negative regulation of ribosome biogenesis
AL501_RS02940	COG1713	HD superfamily hydrolase involved in NAD metabolism
AL501_RS02950	COG1534	Rna-binding protein
AL501_RS02960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL501_RS02965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AL501_RS02970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL501_RS02975	COG1914	H( )-stimulated, divalent metal cation uptake system
AL501_RS02985	COG0439	Biotin carboxylase
AL501_RS02990	COG0511	ligase activity, forming carbon-carbon bonds
AL501_RS02995	COG1984	allophanate hydrolase subunit 2
AL501_RS03000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL501_RS03005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL501_RS03010	COG0572	uridine kinase
AL501_RS03015	COG0826	peptidase U32
AL501_RS03020	COG0826	peptidase U32
AL501_RS03025	COG4122	O-methyltransferase activity
AL501_RS03035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL501_RS03040	COG4472	Bacterial protein of unknown function (DUF965)
AL501_RS03045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL501_RS03050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL501_RS03060	COG0482	sulfurtransferase activity
AL501_RS03065	COG1104	cysteine desulfurase activity
AL501_RS03070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL501_RS03080	COG1959	2 iron, 2 sulfur cluster binding
AL501_RS03085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL501_RS03090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL501_RS03100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL501_RS03105	COG0124	histidyl-tRNA synthetase
AL501_RS03110	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL501_RS03115	COG1490	D-aminoacyl-tRNA deacylase activity
AL501_RS03120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL501_RS03130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL501_RS03130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL501_RS03135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL501_RS03135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL501_RS03140	COG1862	Preprotein translocase
AL501_RS03145	COG0343	queuine tRNA-ribosyltransferase activity
AL501_RS03150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL501_RS03155	COG2255	four-way junction helicase activity
AL501_RS03160	COG0632	four-way junction helicase activity
AL501_RS03165	COG4492	Belongs to the UPF0735 family
AL501_RS03170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL501_RS03180	COG2868	ribosomal protein
AL501_RS03185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL501_RS03195	COG1792	Involved in formation and maintenance of cell shape
AL501_RS03210	COG2003	Belongs to the UPF0758 family
AL501_RS03220	COG0285	dihydrofolate synthase activity
AL501_RS03225	COG0525	valine-tRNA ligase activity
AL501_RS03230	COG2818	Glycosylase
AL501_RS03240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL501_RS03255	COG0181	hydroxymethylbilane synthase activity
AL501_RS03260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL501_RS03275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL501_RS03280	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL501_RS03290	COG4112	unkown
AL501_RS03295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL501_RS03300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL501_RS03305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL501_RS03310	COG0833	amino acid
AL501_RS03320	COG1484	DNA-dependent DNA replication
AL501_RS03325	COG3611	Membrane attachment protein
AL501_RS03330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL501_RS03335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL501_RS03340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL501_RS03345	COG0237	dephospho-CoA kinase activity
AL501_RS03350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL501_RS03355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS03355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL501_RS03360	COG5002	protein histidine kinase activity
AL501_RS03365	COG0745	RESPONSE REGULATOR receiver
AL501_RS03370	COG0538	isocitrate dehydrogenase activity
AL501_RS03375	COG0372	Belongs to the citrate synthase family
AL501_RS03380	COG1113	amino acid transport
AL501_RS03385	COG0469	pyruvate kinase activity
AL501_RS03390	COG0205	6-phosphofructokinase activity
AL501_RS03395	COG0825	malonyl-CoA metabolic process
AL501_RS03400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL501_RS03405	COG0281	malic enzyme
AL501_RS03410	COG0587	DNA-directed DNA polymerase activity
AL501_RS03415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL501_RS03420	COG4109	DRTGG domain
AL501_RS03430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL501_RS03435	COG0006	proline dipeptidase activity
AL501_RS03440	COG0686	Belongs to the AlaDH PNT family
AL501_RS03445	COG0589	response to stress
AL501_RS03450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL501_RS03455	COG0827	DNA restriction-modification system
AL501_RS03460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL501_RS03465	COG0730	response to heat
AL501_RS03470	COG0301	tRNA thio-modification
AL501_RS03475	COG1104	cysteine desulfurase activity
AL501_RS03480	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL501_RS03485	COG1956	GAF domain-containing protein
AL501_RS03495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL501_RS03500	COG0584	glycerophosphoryl diester phosphodiesterase
AL501_RS03505	COG1764	response to oxidative stress
AL501_RS03510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL501_RS03515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL501_RS03525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS03525	COG1263	PTS System
AL501_RS03530	COG0204	Acyl-transferase
AL501_RS03535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL501_RS03540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL501_RS03550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL501_RS03555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL501_RS03560	COG0454	-acetyltransferase
AL501_RS03565	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL501_RS03575	COG1609	Transcriptional regulator
AL501_RS03580	COG1605	Chorismate mutase
AL501_RS03580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL501_RS03590	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AL501_RS03595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL501_RS03600	COG1674	ftsk spoiiie
AL501_RS03605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS03610	COG4848	Belongs to the UPF0354 family
AL501_RS03615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS03620	COG1363	Peptidase, m42
AL501_RS03625	COG5584	Small secreted protein
AL501_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL501_RS03635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL501_RS03640	COG0510	thiamine kinase activity
AL501_RS03650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL501_RS03660	COG1187	pseudouridine synthase activity
AL501_RS03665	COG2244	polysaccharide biosynthetic process
AL501_RS03670	COG2081	HI0933 family
AL501_RS03680	COG0495	leucyl-tRNA aminoacylation
AL501_RS03685	COG2814	Major facilitator Superfamily
AL501_RS03690	COG1242	4 iron, 4 sulfur cluster binding
AL501_RS03695	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AL501_RS03705	COG2267	carboxylic ester hydrolase activity
AL501_RS03710	COG0506	proline dehydrogenase activity
AL501_RS03715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL501_RS03720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL501_RS03720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL501_RS03730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL501_RS03730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL501_RS03740	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL501_RS03740	COG3266	domain, Protein
AL501_RS03740	COG4193	domain, Protein
AL501_RS03765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL501_RS03780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL501_RS03785	COG0656	L-ascorbic acid biosynthetic process
AL501_RS03795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL501_RS03800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL501_RS03805	COG1506	peptidase
AL501_RS03815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL501_RS03825	COG0318	PFAM AMP-dependent synthetase and ligase
AL501_RS03940	COG3545	Serine hydrolase
AL501_RS03945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL501_RS03955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL501_RS03960	COG2329	Antibiotic biosynthesis monooxygenase
AL501_RS03965	COG4473	ABC transporter
AL501_RS03970	COG1131	(ABC) transporter
AL501_RS03975	COG0537	adenosine 5'-monophosphoramidase activity
AL501_RS03990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL501_RS04015	COG0420	3'-5' exonuclease activity
AL501_RS04020	COG3679	Belongs to the UPF0342 family
AL501_RS04035	COG2197	response regulator
AL501_RS04040	COG2203	Gaf domain
AL501_RS04040	COG4585	Histidine kinase
AL501_RS04045	COG0564	pseudouridine synthase activity
AL501_RS04050	COG0114	fumarate hydratase activity
AL501_RS04065	COG0363	glucosamine-6-phosphate deaminase activity
AL501_RS04075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL501_RS04080	COG1126	abc transporter atp-binding protein
AL501_RS04085	COG0765	amino acid transport
AL501_RS04250	COG0735	belongs to the Fur family
AL501_RS04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL501_RS04265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL501_RS04270	COG4129	membrane
AL501_RS04280	COG3557	Belongs to the UPF0374 family
AL501_RS04285	COG1194	a g-specific adenine glycosylase
AL501_RS04290	COG1988	membrane-bound metal-dependent
AL501_RS04300	COG1388	LysM domain
AL501_RS04300	COG1134	teichoic acid transport
AL501_RS04310	COG2137	regulation of response to DNA damage stimulus
AL501_RS04315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL501_RS04320	COG0693	protein deglycase activity
AL501_RS04330	COG0535	radical SAM domain protein
AL501_RS04335	COG1607	acyl-coa hydrolase
AL501_RS04340	COG2309	aminopeptidase activity
AL501_RS04345	COG4840	Belongs to the UPF0435 family
AL501_RS04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL501_RS04360	COG1295	ribonuclease BN
AL501_RS04385	COG0024	Methionine aminopeptidase
AL501_RS04390	COG4129	membrane
AL501_RS04395	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL501_RS04415	COG1528	Iron-storage protein
AL501_RS04440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL501_RS04445	COG1597	lipid kinase activity
AL501_RS04450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL501_RS04455	COG0154	amidase activity
AL501_RS04465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL501_RS04475	COG4851	CamS sex pheromone cAM373 precursor
AL501_RS04480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL501_RS04490	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AL501_RS04495	COG4496	protein, YerC YecD
AL501_RS04500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL501_RS04510	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AL501_RS04515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL501_RS04520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL501_RS04530	COG0077	Prephenate dehydratase
AL501_RS04550	COG1335	isochorismatase
AL501_RS04555	COG1227	inorganic diphosphatase activity
AL501_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS04565	COG2706	6-phosphogluconolactonase activity
AL501_RS04605	COG1131	(ABC) transporter
AL501_RS04615	COG1129	ABC transporter
AL501_RS04615	COG0842	Transport permease protein
AL501_RS04620	COG1725	Transcriptional regulator
AL501_RS04635	COG0459	protein refolding
AL501_RS04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL501_RS04665	COG4512	PFAM Accessory gene regulator B
AL501_RS04675	COG3290	protein histidine kinase activity
AL501_RS04685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL501_RS04690	COG1621	beta-fructofuranosidase activity
AL501_RS04695	COG1609	Transcriptional regulator
AL501_RS04700	COG0004	ammonium transporteR
AL501_RS04705	COG0425	Belongs to the sulfur carrier protein TusA family
AL501_RS04710	COG2391	methyltransferase activity
AL501_RS04715	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AL501_RS04720	COG0488	(ABC) transporter
AL501_RS04725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL501_RS04730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL501_RS04735	COG0456	acetyltransferase
AL501_RS04740	COG1214	PFAM Peptidase M22, glycoprotease
AL501_RS04745	COG0802	atpase or kinase
AL501_RS04755	COG0028	Belongs to the TPP enzyme family
AL501_RS04765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL501_RS04770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL501_RS04785	COG0066	3-isopropylmalate dehydratase activity
AL501_RS04790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL501_RS04830	COG2183	response to ionizing radiation
AL501_RS04835	COG1191	sigma factor activity
AL501_RS04850	COG2208	phosphoserine phosphatase activity
AL501_RS04855	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL501_RS04870	COG0736	holo-[acyl-carrier-protein] synthase activity
AL501_RS04880	COG3428	Bacterial PH domain
AL501_RS04890	COG0513	Belongs to the DEAD box helicase family
AL501_RS04895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL501_RS04900	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL501_RS04905	COG0772	Belongs to the SEDS family
AL501_RS04920	COG1937	Protein conserved in bacteria
AL501_RS04925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL501_RS04930	COG1418	mRNA catabolic process
AL501_RS04935	COG0706	membrane insertase activity
AL501_RS04940	COG0352	thiamine-phosphate diphosphorylase activity
AL501_RS04945	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL501_RS04955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL501_RS04965	COG0629	single-stranded DNA binding
AL501_RS04975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL501_RS04980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL501_RS04985	COG4836	Membrane
AL501_RS04995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL501_RS05000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL501_RS05010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL501_RS05015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL501_RS05020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL501_RS05025	COG0356	it plays a direct role in the translocation of protons across the membrane
AL501_RS05040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL501_RS05045	COG4475	Protein of unknown function (DUF436)
AL501_RS05050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL501_RS05055	COG0009	L-threonylcarbamoyladenylate synthase
AL501_RS05060	COG2890	protein-(glutamine-N5) methyltransferase activity
AL501_RS05065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL501_RS05075	COG0254	rRNA binding
AL501_RS05080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL501_RS05085	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS05095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL501_RS05100	COG0191	fructose-bisphosphate aldolase activity
AL501_RS05110	COG0504	CTP synthase activity
AL501_RS05115	COG3343	RNA polymerase activity
AL501_RS05125	COG5146	pantothenate kinase activity
AL501_RS05145	COG1854	S-ribosylhomocysteine lyase activity
AL501_RS05175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL501_RS05180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL501_RS05185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL501_RS05190	COG0813	purine-nucleoside phosphorylase activity
AL501_RS05195	COG0783	Belongs to the Dps family
AL501_RS05215	COG1482	cell wall glycoprotein biosynthetic process
AL501_RS05220	COG0702	epimerase
AL501_RS05225	COG0640	Transcriptional regulator
AL501_RS05245	COG0561	phosphatase activity
AL501_RS05315	COG0489	protein tyrosine kinase activity
AL501_RS05320	COG2814	Major facilitator Superfamily
AL501_RS05335	COG1272	protein, Hemolysin III
AL501_RS05340	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AL501_RS05345	COG1988	membrane-bound metal-dependent
AL501_RS05355	COG3314	Sporulation integral membrane protein YlbJ
AL501_RS05360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS05365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS05370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL501_RS05400	COG0604	alcohol dehydrogenase
AL501_RS05405	COG2130	NADP-dependent
AL501_RS05415	COG2723	6-phospho-beta-galactosidase activity
AL501_RS05420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL501_RS05420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL501_RS05425	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL501_RS05430	COG3684	Belongs to the aldolase LacD family
AL501_RS05435	COG1105	Belongs to the carbohydrate kinase PfkB family
AL501_RS05440	COG0698	ribose 5-phosphate isomerase
AL501_RS05445	COG0698	ribose 5-phosphate isomerase
AL501_RS05450	COG1349	DNA-binding transcription factor activity
AL501_RS05455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL501_RS05495	COG1309	transcriptional regulator
AL501_RS05505	COG1131	(ABC) transporter
AL501_RS05515	COG1131	(ABC) transporter
AL501_RS05535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL501_RS05540	COG0101	tRNA pseudouridine synthase activity
AL501_RS05550	COG1122	ATPase activity
AL501_RS05560	COG0203	ribosomal protein L17
AL501_RS05565	COG0202	RNA polymerase activity
AL501_RS05575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL501_RS05580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL501_RS05585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL501_RS05590	COG0563	adenylate kinase activity
AL501_RS05595	COG0201	protein transport
AL501_RS05605	COG1841	ribosomal large subunit assembly
AL501_RS05610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL501_RS05615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL501_RS05620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL501_RS05625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL501_RS05640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL501_RS05650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL501_RS05660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL501_RS05665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL501_RS05675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL501_RS05680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL501_RS05685	COG0089	rRNA binding
AL501_RS05690	COG0088	Forms part of the polypeptide exit tunnel
AL501_RS05695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL501_RS05710	COG2252	PERMEase
AL501_RS05735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL501_RS05740	COG2348	transferase activity, transferring amino-acyl groups
AL501_RS05765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL501_RS05770	COG0746	molybdenum cofactor guanylyltransferase activity
AL501_RS05805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL501_RS05810	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL501_RS05815	COG4149	molybdate abc transporter
AL501_RS05820	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL501_RS05825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL501_RS05835	COG1268	BioY protein
AL501_RS05845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS05850	COG1960	acyl-CoA dehydrogenase activity
AL501_RS05880	COG3942	CHAP domain
AL501_RS05885	COG1757	Na H antiporter
AL501_RS05900	COG3942	CHAP domain
AL501_RS05905	COG2076	Multidrug Resistance protein
AL501_RS05910	COG2076	Multidrug Resistance protein
AL501_RS05915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS05945	COG1316	TRANSCRIPTIONal
AL501_RS05955	COG1349	DNA-binding transcription factor activity
AL501_RS05965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL501_RS05970	COG1263	PTS System
AL501_RS05970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS05975	COG1737	Transcriptional regulator
AL501_RS05980	COG1113	amino acid transport
AL501_RS06000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL501_RS06010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS06010	COG1263	PTS System
AL501_RS06015	COG1737	Transcriptional regulator
AL501_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS06040	COG1473	amidohydrolase
AL501_RS06050	COG1266	CAAX protease self-immunity
AL501_RS06055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL501_RS06060	COG2258	MOSC domain
AL501_RS06065	COG2017	converts alpha-aldose to the beta-anomer
AL501_RS06075	COG2094	Belongs to the DNA glycosylase MPG family
AL501_RS06080	COG1304	FMN binding
AL501_RS06085	COG0598	Magnesium transport protein CorA
AL501_RS06110	COG2814	Major facilitator Superfamily
AL501_RS06115	COG1566	PFAM secretion protein HlyD family protein
AL501_RS06125	COG2814	Major facilitator Superfamily
AL501_RS06175	COG0579	oxidoreductase
AL501_RS06180	COG0297	glycogen (starch) synthase activity
AL501_RS06185	COG1620	l-lactate permease
AL501_RS06190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS06200	COG0456	acetyltransferase
AL501_RS06205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL501_RS06210	COG0805	protein transport
AL501_RS06215	COG0672	)-iron permease
AL501_RS06220	COG2837	iron assimilation
AL501_RS06225	COG2822	iron ion transport
AL501_RS06230	COG0604	alcohol dehydrogenase
AL501_RS06240	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS06245	COG2314	TM2 domain
AL501_RS06260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL501_RS06305	COG0583	DNA-binding transcription factor activity
AL501_RS06310	COG2814	Major facilitator Superfamily
AL501_RS06335	COG0488	(ABC) transporter
AL501_RS06350	COG2962	Rard protein
AL501_RS06355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL501_RS06360	COG4716	Myosin-crossreactive antigen
AL501_RS06370	COG4413	Urea transporter
AL501_RS06375	COG0831	urea catabolic process
AL501_RS06385	COG0804	urea catabolic process
AL501_RS06390	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL501_RS06405	COG0829	nickel cation binding
AL501_RS06415	COG0601	transmembrane transport
AL501_RS06425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS06430	COG1124	(ABC) transporter
AL501_RS06440	COG0534	Mate efflux family protein
AL501_RS06465	COG1263	PTS System
AL501_RS06465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS06500	COG1846	Transcriptional regulator
AL501_RS06505	COG2223	nitrite transmembrane transporter activity
AL501_RS06515	COG4585	Histidine kinase
AL501_RS06525	COG2181	nitrate reductase activity
AL501_RS06535	COG1140	nitrate reductase beta subunit
AL501_RS06540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL501_RS06550	COG2146	nitrite reductase [NAD(P)H] activity
AL501_RS06555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL501_RS06565	COG2116	formate transmembrane transporter activity
AL501_RS06575	COG1131	(ABC) transporter
AL501_RS06615	COG1126	abc transporter atp-binding protein
AL501_RS06620	COG0765	amino acid transport
AL501_RS06625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL501_RS06630	COG2814	Major facilitator Superfamily
AL501_RS06640	COG0588	phosphoglycerate mutase activity
AL501_RS06645	COG0741	lytic transglycosylase activity
AL501_RS06650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL501_RS06660	COG1929	Belongs to the glycerate kinase type-1 family
AL501_RS06670	COG2814	Major facilitator Superfamily
AL501_RS06690	COG1113	amino acid transport
AL501_RS06710	COG0531	amino acid
AL501_RS06720	COG0706	membrane insertase activity
AL501_RS06735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL501_RS06745	COG3275	phosphorelay sensor kinase activity
AL501_RS06750	COG3279	Response regulator of the LytR AlgR family
AL501_RS06760	COG1380	Effector of murein hydrolase LrgA
AL501_RS06765	COG1346	cytolysis
AL501_RS06805	COG1174	glycine betaine transport
AL501_RS06825	COG1063	alcohol dehydrogenase
AL501_RS06830	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AL501_RS06835	COG2272	Belongs to the type-B carboxylesterase lipase family
AL501_RS06840	COG2814	Major facilitator Superfamily
AL501_RS06850	COG0745	RESPONSE REGULATOR receiver
AL501_RS06855	COG2205	protein histidine kinase activity
AL501_RS06860	COG0390	transport system, permease component
AL501_RS06865	COG4619	ABC transporter
AL501_RS06880	COG0069	glutamate synthase activity
AL501_RS06885	COG0737	Belongs to the 5'-nucleotidase family
AL501_RS06900	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL501_RS06905	COG3639	organic phosphonate transmembrane transporter activity
AL501_RS06925	COG1363	Peptidase, m42
AL501_RS06930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL501_RS06940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL501_RS06945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL501_RS06950	COG4221	oxidoreductase activity
AL501_RS06965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS06970	COG0438	transferase activity, transferring glycosyl groups
AL501_RS06975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL501_RS06990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL501_RS06995	COG2610	gluconate transmembrane transporter activity
AL501_RS07000	COG1070	Carbohydrate kinase
AL501_RS07005	COG1802	Transcriptional regulator
AL501_RS07020	COG2357	RelA SpoT domain protein
AL501_RS07025	COG4876	unkown
AL501_RS07040	COG2271	Major facilitator Superfamily
AL501_RS07060	COG2022	thiamine diphosphate biosynthetic process
AL501_RS07070	COG0586	Pfam SNARE associated Golgi protein
AL501_RS07075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AL501_RS07085	COG3949	Membrane
AL501_RS07090	COG0400	carboxylic ester hydrolase activity
AL501_RS07095	COG0346	lactoylglutathione lyase activity
AL501_RS07100	COG0346	lactoylglutathione lyase activity
AL501_RS07105	COG1846	Transcriptional regulator
AL501_RS07130	COG2388	GCN5-related N-acetyl-transferase
AL501_RS07135	COG2514	catechol 2,3-dioxygenase activity
AL501_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07150	COG0778	Nitroreductase
AL501_RS07155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS07160	COG0561	phosphatase activity
AL501_RS07170	COG3764	Sortase (surface protein transpeptidase)
AL501_RS07180	COG1760	l-serine dehydratase
AL501_RS07185	COG1760	l-serine dehydratase
AL501_RS07195	COG1070	Carbohydrate kinase
AL501_RS07215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL501_RS07225	COG0657	acetylesterase activity
AL501_RS07230	COG0039	L-malate dehydrogenase activity
AL501_RS07240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS07255	COG0028	Belongs to the TPP enzyme family
AL501_RS07260	COG1346	cytolysis
AL501_RS07265	COG1380	Effector of murein hydrolase LrgA
AL501_RS07270	COG0583	DNA-binding transcription factor activity
AL501_RS07280	COG3942	CHAP domain
AL501_RS07280	COG1388	LysM domain
AL501_RS07295	COG3425	synthase
AL501_RS07305	COG1131	(ABC) transporter
AL501_RS07330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL501_RS07335	COG0598	Magnesium transport protein CorA
AL501_RS07355	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL501_RS07365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS07370	COG0110	maltose O-acetyltransferase activity
AL501_RS07380	COG2217	Heavy metal translocating P-type atpase
AL501_RS07385	COG2608	mercury ion transmembrane transporter activity
AL501_RS07400	COG0436	Aminotransferase
AL501_RS07420	COG3189	MarR family transcriptional regulator
AL501_RS07435	COG1113	amino acid transport
AL501_RS07445	COG2814	Major facilitator Superfamily
AL501_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS07500	COG3001	Fructosamine kinase
AL501_RS07505	COG0167	dihydroorotate dehydrogenase activity
AL501_RS07525	COG1620	l-lactate permease
AL501_RS07530	COG3527	Alpha-acetolactate decarboxylase
AL501_RS07535	COG0028	Belongs to the TPP enzyme family
AL501_RS07540	COG0583	DNA-binding transcription factor activity
AL501_RS07545	COG0531	amino acid
AL501_RS07555	COG1215	transferase activity, transferring glycosyl groups
AL501_RS07555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS07565	COG0463	Glycosyl transferase, family 2
AL501_RS07575	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS07590	COG3588	fructose-bisphosphate aldolase
AL501_RS07605	COG0583	DNA-binding transcription factor activity
AL501_RS07615	COG2723	6-phospho-beta-galactosidase activity
AL501_RS07620	COG1263	PTS System
AL501_RS07620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS07620	COG2190	(PTS) system
AL501_RS07625	COG2188	Transcriptional regulator
AL501_RS07635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL501_RS07640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL501_RS07640	COG0574	Belongs to the PEP-utilizing enzyme family
AL501_RS07645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL501_RS07660	COG1473	amidohydrolase
AL501_RS07665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL501_RS07670	COG1012	belongs to the aldehyde dehydrogenase family
AL501_RS07675	COG1510	regulation of RNA biosynthetic process
AL501_RS07680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL501_RS07685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL501_RS07690	COG0602	queuosine metabolic process
AL501_RS07695	COG1328	CTP reductase activity
AL501_RS07710	COG0529	Catalyzes the synthesis of activated sulfate
AL501_RS07715	COG2046	Belongs to the sulfate adenylyltransferase family
AL501_RS07720	COG0730	response to heat
AL501_RS07735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL501_RS07740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL501_RS07745	COG0175	sulfate reduction
AL501_RS07750	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL501_RS07750	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AL501_RS07750	COG3266	domain, Protein
AL501_RS07750	COG3266	domain, Protein
AL501_RS07750	COG4932	domain protein
AL501_RS07750	COG4932	domain protein
AL501_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS07930	COG1136	(ABC) transporter
AL501_RS07935	COG2205	protein histidine kinase activity
AL501_RS07940	COG0745	RESPONSE REGULATOR receiver
AL501_RS07950	COG1785	Belongs to the alkaline phosphatase family
AL501_RS07955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL501_RS07960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL501_RS07965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL501_RS07975	COG0297	glycogen (starch) synthase activity
AL501_RS08000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL501_RS08040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL501_RS08045	COG4195	phage-related replication protein
AL501_RS08050	COG2843	Capsule synthesis protein
AL501_RS08060	COG2235	arginine
AL501_RS08085	COG3942	CHAP domain
AL501_RS08085	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL501_RS08120	COG1476	TRANSCRIPTIONal
AL501_RS08130	COG1122	ATPase activity
AL501_RS08140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL501_RS08155	COG3386	PFAM SMP-30 Gluconolaconase
AL501_RS08160	COG1054	Belongs to the UPF0176 family
AL501_RS08165	COG3037	sugar-specific permease SgaT UlaA
AL501_RS08175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08180	COG3711	transcriptional antiterminator
AL501_RS08180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08185	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL501_RS08205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL501_RS08210	COG1266	CAAX protease self-immunity
AL501_RS08240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS08245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL501_RS08250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL501_RS08265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL501_RS08270	COG0363	glucosamine-6-phosphate deaminase activity
AL501_RS08280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL501_RS08300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL501_RS08355	COG0531	amino acid
AL501_RS08365	COG0706	membrane insertase activity
AL501_RS08390	COG1482	cell wall glycoprotein biosynthetic process
AL501_RS08395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS08395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS08395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS08400	COG3711	transcriptional antiterminator
AL501_RS08420	COG1695	Transcriptional regulator
AL501_RS08430	COG0022	dehydrogenase e1 component
AL501_RS08435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL501_RS08440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS08450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL501_RS08465	COG3976	FMN-binding domain protein
AL501_RS08465	COG1053	succinate dehydrogenase
AL501_RS08465	COG0431	NADPH-dependent FMN reductase
AL501_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08500	COG2190	(PTS) system
AL501_RS08500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS08500	COG1263	PTS System
AL501_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08530	COG2814	Major facilitator Superfamily
AL501_RS08540	COG1288	antiporter activity
AL501_RS08545	COG2353	YceI-like domain
AL501_RS08555	COG1131	(ABC) transporter
AL501_RS08570	COG3961	Belongs to the TPP enzyme family
AL501_RS08575	COG1124	(ABC) transporter
AL501_RS08580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS08590	COG0601	transmembrane transport
AL501_RS08595	COG0747	negative chemotaxis
AL501_RS08600	COG2264	protein methyltransferase activity
AL501_RS08625	COG1131	(ABC) transporter
AL501_RS08640	COG2814	Major facilitator Superfamily
AL501_RS08660	COG1233	COG1233 Phytoene dehydrogenase and related
AL501_RS08670	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AL501_RS08675	COG2311	Membrane
AL501_RS08690	COG1278	Cold shock
AL501_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS08710	COG1131	(ABC) transporter
AL501_RS08725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL501_RS08745	COG1033	growth of symbiont in host cell
AL501_RS08745	COG2409	Drug exporters of the RND superfamily
AL501_RS08785	COG0657	acetylesterase activity
AL501_RS08790	COG0505	Belongs to the CarA family
AL501_RS08795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL501_RS08795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL501_RS08800	COG0531	amino acid
AL501_RS08805	COG0693	protein deglycase activity
AL501_RS08820	COG1124	(ABC) transporter
AL501_RS08825	COG0444	Belongs to the ABC transporter superfamily
AL501_RS08835	COG0601	transmembrane transport
AL501_RS08850	COG2814	Major facilitator Superfamily
AL501_RS08855	COG0561	phosphatase activity
AL501_RS08860	COG0464	growth
AL501_RS08870	COG1114	Component of the transport system for branched-chain amino acids
AL501_RS08880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL501_RS08885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL501_RS08890	COG1177	transmembrane transport
AL501_RS08895	COG1840	ABC-type Fe3 transport system, periplasmic component
AL501_RS08900	COG3842	ATPase activity
AL501_RS08905	COG0583	DNA-binding transcription factor activity
AL501_RS08940	COG5002	protein histidine kinase activity
AL501_RS08950	COG1349	DNA-binding transcription factor activity
AL501_RS08955	COG0534	Mate efflux family protein
AL501_RS08965	COG0395	ABC-type sugar transport system, permease component
AL501_RS08975	COG4209	transmembrane transport
AL501_RS08980	COG3842	ATPase activity
AL501_RS08990	COG1846	Transcriptional regulator
AL501_RS09000	COG2808	Putative FMN-binding domain
AL501_RS09005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS09010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS09020	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL501_RS09020	COG3942	CHAP domain
AL501_RS09030	COG4509	Sortase family
AL501_RS09065	COG1129	ABC transporter
AL501_RS09090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL501_RS09095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL501_RS09105	COG2205	protein histidine kinase activity
AL501_RS09110	COG0745	RESPONSE REGULATOR receiver
AL501_RS09120	COG3716	PTS system mannose fructose sorbose family IID component
AL501_RS09125	COG3715	PTS system
AL501_RS09130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL501_RS09135	COG3684	Belongs to the aldolase LacD family
AL501_RS09140	COG2222	sugar isomerase
AL501_RS09145	COG2188	Transcriptional regulator
AL501_RS09210	COG1131	(ABC) transporter
AL501_RS09225	COG0745	RESPONSE REGULATOR receiver
AL501_RS09265	COG1129	ABC transporter
AL501_RS09290	COG1073	alpha beta
AL501_RS09320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL501_RS09330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL501_RS09340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL501_RS09345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL501_RS09380	COG4863	YycH protein
AL501_RS09385	COG5002	protein histidine kinase activity
AL501_RS09390	COG0745	RESPONSE REGULATOR receiver
AL501_RS09405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL501_RS09410	COG0305	Participates in initiation and elongation during chromosome replication
AL501_RS09415	COG0359	binds to the 23S rRNA
AL501_RS09420	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AL501_RS09430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL501_RS09440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AL501_RS09450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL501_RS09455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL501_RS09460	COG0187	DNA topoisomerase II activity
AL501_RS09465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL501_RS09470	COG2501	S4 domain
AL501_RS09475	COG0592	DNA-directed DNA polymerase activity
AL501_RS09480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL501_RS09490	COG0594	ribonuclease P activity
AL501_RS09495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL501_RS09500	COG0445	tRNA wobble uridine modification
AL501_RS09510	COG1475	DNA binding
AL501_RS09530	COG1063	alcohol dehydrogenase
AL501_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
AL501_RS09555	COG1396	sequence-specific DNA binding
AL501_RS09565	COG0577	efflux transmembrane transporter activity
AL501_RS09570	COG1136	(ABC) transporter
AL501_RS09585	COG2271	Major facilitator Superfamily
AL501_RS09590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL501_RS09595	COG3878	Protein conserved in bacteria
AL501_RS09620	COG0745	RESPONSE REGULATOR receiver
AL501_RS09635	COG2205	protein histidine kinase activity
AL501_RS09655	COG1136	(ABC) transporter
AL501_RS09660	COG0577	efflux transmembrane transporter activity
AL501_RS09685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL501_RS09690	COG0646	methionine synthase
AL501_RS09690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL501_RS09695	COG0626	cystathionine gamma-synthase activity
AL501_RS09700	COG0626	cystathionine gamma-synthase activity
AL501_RS09710	COG1475	DNA binding
AL501_RS09715	COG0668	transmembrane transport
AL501_RS09720	COG4481	Protein conserved in bacteria
AL501_RS09725	COG0012	GTP binding
AL501_RS09740	COG0360	Binds together with S18 to 16S ribosomal RNA
AL501_RS09750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL501_RS09790	COG0588	phosphoglycerate mutase activity
AL501_RS09805	COG3634	alkyl hydroperoxide reductase activity
AL501_RS09810	COG0450	alkyl hydroperoxide reductase
AL501_RS09820	COG0778	Nitroreductase
AL501_RS09830	COG1823	symporter activity
AL501_RS09850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL501_RS09855	COG2233	PERMEase
AL501_RS09860	COG0517	IMP dehydrogenase activity
AL501_RS09860	COG0516	GMP reductase activity
AL501_RS09865	COG0519	Catalyzes the synthesis of GMP from XMP
AL501_RS09865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL501_RS09885	COG0523	cobalamin synthesis protein
AL501_RS09895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL501_RS09900	COG3002	Belongs to the UPF0753 family
AL501_RS09905	COG5609	conserved protein (DUF2294)
AL501_RS09925	COG0733	neurotransmitter:sodium symporter activity
AL501_RS09935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL501_RS09940	COG0626	cystathionine gamma-synthase activity
AL501_RS09945	COG2375	cellular response to nickel ion
AL501_RS09945	COG1132	(ABC) transporter
AL501_RS09950	COG1132	(ABC) transporter
AL501_RS09955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS09960	COG2011	ABC-type metal ion transport system permease component
AL501_RS09965	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS10000	COG0583	DNA-binding transcription factor activity
AL501_RS10005	COG0070	glutamate synthase
AL501_RS10005	COG0067	glutamate synthase
AL501_RS10005	COG0069	glutamate synthase activity
AL501_RS10010	COG0493	'glutamate synthase
AL501_RS10025	COG0366	Alpha amylase catalytic
AL501_RS10030	COG2188	Transcriptional regulator
AL501_RS10045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL501_RS10055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL501_RS10095	COG1982	Orn Lys Arg decarboxylase major
AL501_RS10100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL501_RS10105	COG3870	Protein conserved in bacteria
AL501_RS10110	COG0470	DNA polymerase III
AL501_RS10115	COG1774	PSP1 C-terminal conserved region
AL501_RS10125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL501_RS10135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL501_RS10140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS10140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL501_RS10145	COG0084	hydrolase, TatD family'
AL501_RS10150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL501_RS10155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL501_RS10160	COG4466	Protein conserved in bacteria
AL501_RS10165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL501_RS10170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL501_RS10175	COG0251	oxidation-reduction process
AL501_RS10185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL501_RS10190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL501_RS10200	COG0193	aminoacyl-tRNA hydrolase activity
AL501_RS10205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL501_RS10210	COG2244	polysaccharide biosynthetic process
AL501_RS10215	COG3956	TIGRFAM MazG family protein
AL501_RS10220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL501_RS10230	COG1098	S1 RNA binding domain
AL501_RS10245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL501_RS10255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL501_RS10265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL501_RS10270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL501_RS10280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL501_RS10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL501_RS10370	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AL501_RS10375	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL501_RS10380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS10385	COG4463	regulation of RNA biosynthetic process
AL501_RS10390	COG3880	PFAM UvrB UvrC protein
AL501_RS10395	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AL501_RS10400	COG0542	response to heat
AL501_RS10405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL501_RS10410	COG4956	integral membrane protein (PIN domain superfamily)
AL501_RS10415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL501_RS10420	COG1045	serine acetyltransferase
AL501_RS10425	COG0215	cysteine-tRNA ligase activity
AL501_RS10430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AL501_RS10435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL501_RS10440	COG3688	RNA-binding protein containing a PIN domain
AL501_RS10450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL501_RS10455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL501_RS10460	COG0250	Participates in transcription elongation, termination and antitermination
AL501_RS10470	COG0081	regulation of translation
AL501_RS10480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL501_RS10485	COG0222	ribosome binding
AL501_RS10490	COG2813	Specifically methylates the guanine in position
AL501_RS10495	COG0085	RNA polymerase activity
AL501_RS10500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL501_RS10510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL501_RS10525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL501_RS10530	COG1473	amidohydrolase
AL501_RS10560	COG1279	arginine transmembrane transporter activity
AL501_RS10570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL501_RS10575	COG0531	amino acid
AL501_RS10595	COG1428	Deoxynucleoside kinase
AL501_RS10600	COG1428	Deoxynucleoside kinase
AL501_RS10610	COG0561	phosphatase activity
AL501_RS10635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS10645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL501_RS10655	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL501_RS10660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL501_RS10690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL501_RS10700	COG2363	Small membrane protein
AL501_RS10735	COG3253	May function as heme-dependent peroxidase
AL501_RS10745	COG0095	Lipoate-protein ligase
AL501_RS10765	COG4844	belongs to the
AL501_RS10770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS10775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AL501_RS10805	COG3561	AntA/AntB antirepressor
AL501_RS10865	COG1484	DNA-dependent DNA replication
AL501_RS10930	COG1783	phage Terminase large subunit
AL501_RS11010	COG5434	Belongs to the glycosyl hydrolase 28 family
AL501_RS11050	COG1388	LysM domain
AL501_RS11050	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL501_RS11065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL501_RS11075	COG0667	Aldo Keto reductase
AL501_RS11080	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL501_RS11090	COG1078	dGTPase activity
AL501_RS11100	COG1064	alcohol dehydrogenase
AL501_RS11120	COG0018	arginyl-trna synthetase
AL501_RS11140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL501_RS11145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11170	COG0596	Alpha beta hydrolase
AL501_RS11200	COG4974	Belongs to the 'phage' integrase family
AL501_RS11205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL501_RS11205	COG2111	Na H antiporter
AL501_RS11210	COG2111	Na H antiporter
AL501_RS11215	COG1006	Multisubunit Na H antiporter MnhC subunit
AL501_RS11220	COG0651	ATP synthesis coupled electron transport
AL501_RS11225	COG1863	multisubunit Na H antiporter MnhE subunit
AL501_RS11230	COG2212	antiporter activity
AL501_RS11235	COG1320	monovalent cation:proton antiporter activity
AL501_RS11245	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL501_RS11250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL501_RS11255	COG1121	(ABC) transporter
AL501_RS11260	COG1321	iron dependent repressor
AL501_RS11270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL501_RS11285	COG1134	teichoic acid transport
AL501_RS11290	COG1682	transport, permease protein
AL501_RS11300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS11305	COG1215	transferase activity, transferring glycosyl groups
AL501_RS11310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL501_RS11315	COG1686	Belongs to the peptidase S11 family
AL501_RS11320	COG1132	(ABC) transporter
AL501_RS11325	COG0438	transferase activity, transferring glycosyl groups
AL501_RS11330	COG0463	Glycosyl transferase, family 2
AL501_RS11330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL501_RS11340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL501_RS11350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL501_RS11355	COG1120	ATPase activity
AL501_RS11360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AL501_RS11380	COG3949	Membrane
AL501_RS11385	COG0657	acetylesterase activity
AL501_RS11395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL501_RS11400	COG0745	RESPONSE REGULATOR receiver
AL501_RS11405	COG2205	protein histidine kinase activity
AL501_RS11410	COG1136	(ABC) transporter
AL501_RS11415	COG0577	efflux transmembrane transporter activity
AL501_RS11420	COG1392	Phosphate transport regulator
AL501_RS11425	COG0306	phosphate transporter
AL501_RS11430	COG1388	LysM domain
AL501_RS11430	COG3942	CHAP domain
AL501_RS11450	COG0217	transcriptional regulatory protein
AL501_RS11470	COG0583	DNA-binding transcription factor activity
AL501_RS11475	COG2814	Major facilitator Superfamily
AL501_RS11480	COG2839	Protein conserved in bacteria
AL501_RS11510	COG1611	Belongs to the LOG family
AL501_RS11515	COG1671	Belongs to the UPF0178 family
AL501_RS11525	COG1968	undecaprenyl-diphosphatase activity
AL501_RS11535	COG0523	cobalamin synthesis protein
AL501_RS11545	COG0039	L-malate dehydrogenase activity
AL501_RS11550	COG0471	metal ion transport
AL501_RS11555	COG0415	Belongs to the DNA photolyase family
AL501_RS11585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL501_RS11590	COG1349	DNA-binding transcription factor activity
AL501_RS11595	COG1105	Belongs to the carbohydrate kinase PfkB family
AL501_RS11600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS11600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL501_RS11600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL501_RS11605	COG1253	flavin adenine dinucleotide binding
AL501_RS11610	COG0656	L-ascorbic acid biosynthetic process
AL501_RS11615	COG0463	Glycosyl transferase, family 2
AL501_RS11630	COG0720	synthase
AL501_RS11640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL501_RS11640	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS11645	COG0512	Glutamine amidotransferase of anthranilate synthase
AL501_RS11645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL501_RS11655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL501_RS11665	COG1368	sulfuric ester hydrolase activity
AL501_RS11675	COG0488	(ABC) transporter
AL501_RS11680	COG0514	ATP-dependent DNA helicase (RecQ)
AL501_RS11690	COG1174	glycine betaine transport
AL501_RS11695	COG3104	oligopeptide transport
AL501_RS11700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL501_RS11710	COG1597	lipid kinase activity
AL501_RS11715	COG3104	oligopeptide transport
AL501_RS11720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL501_RS11730	COG1780	Probably involved in ribonucleotide reductase function
AL501_RS11735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL501_RS11740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL501_RS11745	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11750	COG4605	iron ion homeostasis
AL501_RS11755	COG4604	ABC transporter, ATP-binding protein
AL501_RS11760	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS11765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL501_RS11770	COG4605	iron ion homeostasis
AL501_RS11775	COG4604	ABC transporter, ATP-binding protein
AL501_RS11780	COG4607	ABC-type enterochelin transport system periplasmic component
AL501_RS11790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL501_RS11810	COG1929	Belongs to the glycerate kinase type-1 family
AL501_RS11815	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL501_RS11830	COG2199	diguanylate cyclase activity
AL501_RS11835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL501_RS11840	COG1739	Uncharacterized protein family UPF0029
AL501_RS11850	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AL501_RS11855	COG1040	competence protein
AL501_RS11860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL501_RS11870	COG0653	protein targeting
AL501_RS11880	COG1388	LysM domain
AL501_RS11880	COG3942	CHAP domain
AL501_RS11900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL501_RS11905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL501_RS11910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL501_RS11925	COG0492	ferredoxin-NADP+ reductase activity
AL501_RS11930	COG1660	Displays ATPase and GTPase activities
AL501_RS11935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL501_RS11940	COG1481	regulation of sporulation
AL501_RS11950	COG0740	serine-type endopeptidase activity
AL501_RS11955	COG1090	epimerase
AL501_RS11975	COG0126	phosphoglycerate kinase activity
AL501_RS11980	COG0149	triose-phosphate isomerase activity
AL501_RS11985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL501_RS11990	COG0148	phosphopyruvate hydratase activity
AL501_RS12000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL501_RS12005	COG1647	Serine aminopeptidase, S33
AL501_RS12010	COG0557	exoribonuclease II activity
AL501_RS12090	COG1611	Belongs to the LOG family
AL501_RS12100	COG0346	lactoylglutathione lyase activity
AL501_RS12105	COG2259	Doxx family
AL501_RS12120	COG4195	phage-related replication protein
AL501_RS12155	COG0588	phosphoglycerate mutase activity
AL501_RS12165	COG1764	response to oxidative stress
AL501_RS12170	COG0710	3-dehydroquinate dehydratase activity
AL501_RS12180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL501_RS12185	COG1393	Belongs to the ArsC family
AL501_RS12190	COG0509	glycine decarboxylation via glycine cleavage system
AL501_RS12195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL501_RS12205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL501_RS12210	COG2011	ABC-type metal ion transport system permease component
AL501_RS12215	COG1464	Belongs to the NlpA lipoprotein family
AL501_RS12235	COG0396	ATPase activity
AL501_RS12240	COG0719	Fe-S assembly protein
AL501_RS12250	COG0822	iron-sulfur transferase activity
AL501_RS12255	COG0719	Fe-S assembly protein
AL501_RS12275	COG3942	CHAP domain
AL501_RS12275	COG1388	LysM domain
AL501_RS12415	COG1253	flavin adenine dinucleotide binding
AL501_RS12420	COG2070	2-Nitropropane dioxygenase
AL501_RS12425	COG1801	Protein of unknown function DUF72
AL501_RS12430	COG0730	response to heat
AL501_RS12435	COG0737	Belongs to the 5'-nucleotidase family
AL501_RS12440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL501_RS12445	COG4470	Protein conserved in bacteria
AL501_RS12455	COG2445	Protein of unknown function DUF86
AL501_RS12460	COG0647	UMP catabolic process
AL501_RS12465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL501_RS12475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL501_RS12480	COG1696	Membrane protein involved in D-alanine export
AL501_RS12485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL501_RS12490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AL501_RS12495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL501_RS12500	COG4837	Protein of unknown function (DUF1462)
AL501_RS12505	COG1252	NADH dehydrogenase
AL501_RS12510	COG4844	belongs to the
AL501_RS12515	COG0316	Belongs to the HesB IscA family
AL501_RS12530	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL501_RS12535	COG3433	isochorismatase activity
AL501_RS12535	COG2226	methyltransferase
AL501_RS12535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL501_RS12565	COG1129	ABC transporter
AL501_RS12575	COG1132	(ABC) transporter
AL501_RS12585	COG1252	NADH dehydrogenase
AL501_RS12590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL501_RS12595	COG2056	Na+-H+ antiporter family
AL501_RS12600	COG2050	protein possibly involved in aromatic compounds catabolism
AL501_RS12610	COG1320	monovalent cation:proton antiporter activity
AL501_RS12615	COG2212	antiporter activity
AL501_RS12620	COG1863	multisubunit Na H antiporter MnhE subunit
AL501_RS12625	COG0651	ATP synthesis coupled electron transport
AL501_RS12630	COG1006	Multisubunit Na H antiporter MnhC subunit
AL501_RS12635	COG2111	Na H antiporter