locus-tag	class	description
CRN64_RS00025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRN64_RS00040	COG0537	adenosine 5'-monophosphoramidase activity
CRN64_RS00045	COG1131	(ABC) transporter
CRN64_RS00050	COG4473	ABC transporter
CRN64_RS00055	COG2329	Antibiotic biosynthesis monooxygenase
CRN64_RS00060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CRN64_RS00070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CRN64_RS00075	COG3545	Serine hydrolase
CRN64_RS00125	COG0318	PFAM AMP-dependent synthetase and ligase
CRN64_RS00135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CRN64_RS00145	COG1506	peptidase
CRN64_RS00150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CRN64_RS00155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRN64_RS00165	COG0656	L-ascorbic acid biosynthetic process
CRN64_RS00170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRN64_RS00185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRN64_RS00210	COG5632	N-Acetylmuramoyl-L-alanine amidase
CRN64_RS00210	COG4193	domain, Protein
CRN64_RS00210	COG3266	domain, Protein
CRN64_RS00220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN64_RS00220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRN64_RS00230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRN64_RS00230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRN64_RS00235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRN64_RS00240	COG0506	proline dehydrogenase activity
CRN64_RS00245	COG2267	carboxylic ester hydrolase activity
CRN64_RS00255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CRN64_RS00260	COG1242	4 iron, 4 sulfur cluster binding
CRN64_RS00265	COG2814	Major facilitator Superfamily
CRN64_RS00270	COG0495	leucyl-tRNA aminoacylation
CRN64_RS00280	COG2081	HI0933 family
CRN64_RS00285	COG2244	polysaccharide biosynthetic process
CRN64_RS00290	COG1187	pseudouridine synthase activity
CRN64_RS00300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRN64_RS00310	COG0510	thiamine kinase activity
CRN64_RS00315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRN64_RS00320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN64_RS00325	COG5584	Small secreted protein
CRN64_RS00330	COG1363	Peptidase, m42
CRN64_RS00335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN64_RS00340	COG4848	Belongs to the UPF0354 family
CRN64_RS00345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN64_RS00350	COG1674	ftsk spoiiie
CRN64_RS00355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRN64_RS00360	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CRN64_RS00370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CRN64_RS00370	COG1605	Chorismate mutase
CRN64_RS00375	COG1609	Transcriptional regulator
CRN64_RS00395	COG0123	including yeast histone deacetylase and acetoin utilization protein
CRN64_RS00400	COG0454	-acetyltransferase
CRN64_RS00405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRN64_RS00410	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CRN64_RS00420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CRN64_RS00425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN64_RS00430	COG0204	Acyl-transferase
CRN64_RS00445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRN64_RS00450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CRN64_RS00455	COG1764	response to oxidative stress
CRN64_RS00460	COG0584	glycerophosphoryl diester phosphodiesterase
CRN64_RS00465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRN64_RS00475	COG1956	GAF domain-containing protein
CRN64_RS00480	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CRN64_RS00485	COG1104	cysteine desulfurase activity
CRN64_RS00490	COG0301	tRNA thio-modification
CRN64_RS00495	COG0730	response to heat
CRN64_RS00500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRN64_RS00505	COG0827	DNA restriction-modification system
CRN64_RS00510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRN64_RS00515	COG0589	response to stress
CRN64_RS00520	COG0686	Belongs to the AlaDH PNT family
CRN64_RS00525	COG0006	proline dipeptidase activity
CRN64_RS00530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRN64_RS00540	COG4109	DRTGG domain
CRN64_RS00545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CRN64_RS00550	COG0587	DNA-directed DNA polymerase activity
CRN64_RS00555	COG0281	malic enzyme
CRN64_RS00560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CRN64_RS00565	COG0825	malonyl-CoA metabolic process
CRN64_RS00570	COG0205	6-phosphofructokinase activity
CRN64_RS00575	COG0469	pyruvate kinase activity
CRN64_RS00585	COG1113	amino acid transport
CRN64_RS00590	COG0372	Belongs to the citrate synthase family
CRN64_RS00595	COG0538	isocitrate dehydrogenase activity
CRN64_RS00600	COG0745	RESPONSE REGULATOR receiver
CRN64_RS00605	COG5002	protein histidine kinase activity
CRN64_RS00610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN64_RS00610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN64_RS00615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRN64_RS00620	COG0237	dephospho-CoA kinase activity
CRN64_RS00625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRN64_RS00630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRN64_RS00635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRN64_RS00640	COG3611	Membrane attachment protein
CRN64_RS00645	COG1484	DNA-dependent DNA replication
CRN64_RS00655	COG0833	amino acid
CRN64_RS00660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CRN64_RS00665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRN64_RS00670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CRN64_RS00675	COG4112	unkown
CRN64_RS00685	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRN64_RS00690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRN64_RS00705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRN64_RS00710	COG0181	hydroxymethylbilane synthase activity
CRN64_RS00725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRN64_RS00735	COG2818	Glycosylase
CRN64_RS00740	COG0525	valine-tRNA ligase activity
CRN64_RS00745	COG0285	dihydrofolate synthase activity
CRN64_RS00755	COG2003	Belongs to the UPF0758 family
CRN64_RS00775	COG1792	Involved in formation and maintenance of cell shape
CRN64_RS00785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CRN64_RS00790	COG2868	ribosomal protein
CRN64_RS00800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRN64_RS00805	COG4492	Belongs to the UPF0735 family
CRN64_RS00810	COG0632	four-way junction helicase activity
CRN64_RS00815	COG2255	four-way junction helicase activity
CRN64_RS00820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CRN64_RS00825	COG0343	queuine tRNA-ribosyltransferase activity
CRN64_RS00830	COG1862	Preprotein translocase
CRN64_RS00835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN64_RS00835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRN64_RS00840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CRN64_RS00840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CRN64_RS00850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRN64_RS00855	COG1490	D-aminoacyl-tRNA deacylase activity
CRN64_RS00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRN64_RS00865	COG0124	histidyl-tRNA synthetase
CRN64_RS00870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRN64_RS00880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CRN64_RS00885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRN64_RS00890	COG1959	2 iron, 2 sulfur cluster binding
CRN64_RS00900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRN64_RS00905	COG1104	cysteine desulfurase activity
CRN64_RS00910	COG0482	sulfurtransferase activity
CRN64_RS00920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRN64_RS00925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRN64_RS00930	COG4472	Bacterial protein of unknown function (DUF965)
CRN64_RS00935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRN64_RS00945	COG4122	O-methyltransferase activity
CRN64_RS00950	COG0826	peptidase U32
CRN64_RS00955	COG0826	peptidase U32
CRN64_RS00960	COG0572	uridine kinase
CRN64_RS00965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRN64_RS00970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRN64_RS00975	COG1984	allophanate hydrolase subunit 2
CRN64_RS00980	COG0511	ligase activity, forming carbon-carbon bonds
CRN64_RS00985	COG0439	Biotin carboxylase
CRN64_RS00995	COG1914	H( )-stimulated, divalent metal cation uptake system
CRN64_RS01000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRN64_RS01005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CRN64_RS01010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CRN64_RS01020	COG1534	Rna-binding protein
CRN64_RS01025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CRN64_RS01030	COG1713	HD superfamily hydrolase involved in NAD metabolism
CRN64_RS01035	COG0799	negative regulation of ribosome biogenesis
CRN64_RS01040	COG2226	methyltransferase
CRN64_RS01045	COG1596	polysaccharide export
CRN64_RS01045	COG1555	photosystem II stabilization
CRN64_RS01050	COG2131	deaminase
CRN64_RS01055	COG2333	competence protein COMEC
CRN64_RS01055	COG0658	competence protein
CRN64_RS01060	COG1466	dna polymerase III delta subunit
CRN64_RS01065	COG0268	Binds directly to 16S ribosomal RNA
CRN64_RS01070	COG0481	GTPase activity
CRN64_RS01075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRN64_RS01085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRN64_RS01090	COG0443	Heat shock 70 kDa protein
CRN64_RS01095	COG0484	heat shock protein binding
CRN64_RS01100	COG2264	protein methyltransferase activity
CRN64_RS01105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRN64_RS01110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRN64_RS01120	COG1030	water channel activity
CRN64_RS01125	COG4864	UPF0365 protein
CRN64_RS01135	COG1702	phosphate starvation-inducible protein PhoH
CRN64_RS01140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CRN64_RS01145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRN64_RS01150	COG0295	cytidine deaminase activity
CRN64_RS01155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CRN64_RS01160	COG1381	Involved in DNA repair and RecF pathway recombination
CRN64_RS01165	COG0423	glycine-tRNA ligase activity
CRN64_RS01170	COG0517	IMP dehydrogenase activity
CRN64_RS01175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CRN64_RS01190	COG2384	SAM-dependent methyltransferase
CRN64_RS01200	COG0513	Belongs to the DEAD box helicase family
CRN64_RS01205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRN64_RS01210	COG1121	(ABC) transporter
CRN64_RS01215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN64_RS01225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRN64_RS01230	COG0768	penicillin binding
CRN64_RS01235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRN64_RS01240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRN64_RS01245	COG0705	Rhomboid family
CRN64_RS01245	COG0457	Tetratricopeptide repeat
CRN64_RS01250	COG4483	Protein conserved in bacteria
CRN64_RS01255	COG1940	carbohydrate kinase activity
CRN64_RS01260	COG0011	TIGRFAM Protein of
CRN64_RS01265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRN64_RS01270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRN64_RS01275	COG1459	type II secretion system
CRN64_RS01280	COG4537	Required for transformation and DNA binding
CRN64_RS01305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRN64_RS01310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CRN64_RS01315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN64_RS01320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRN64_RS01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRN64_RS01330	COG0095	Lipoate-protein ligase
CRN64_RS01350	COG0006	proline dipeptidase activity
CRN64_RS01355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRN64_RS01360	COG0511	ligase activity, forming carbon-carbon bonds
CRN64_RS01365	COG0439	Biotin carboxylase
CRN64_RS01370	COG1302	Protein conserved in bacteria
CRN64_RS01375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRN64_RS01395	COG1438	arginine binding
CRN64_RS01400	COG0497	DNA recombination
CRN64_RS01405	COG0280	phosphate acetyltransferase
CRN64_RS01410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN64_RS01415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CRN64_RS01420	COG0022	dehydrogenase e1 component
CRN64_RS01425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRN64_RS01435	COG4129	membrane
CRN64_RS01445	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRN64_RS01455	COG1609	Transcriptional regulator
CRN64_RS01460	COG0366	Alpha amylase catalytic
CRN64_RS01470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CRN64_RS01480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRN64_RS01485	COG0300	oxidoreductase activity
CRN64_RS01490	COG0667	Aldo Keto reductase
CRN64_RS01495	COG0494	nUDIX hydrolase
CRN64_RS01500	COG0735	belongs to the Fur family
CRN64_RS01505	COG4974	Belongs to the 'phage' integrase family
CRN64_RS01515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CRN64_RS01520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CRN64_RS01525	COG1187	pseudouridine synthase activity
CRN64_RS01530	COG0745	RESPONSE REGULATOR receiver
CRN64_RS01545	COG1141	Ferredoxin
CRN64_RS01555	COG0514	ATP-dependent DNA helicase (RecQ)
CRN64_RS01560	COG1388	LysM domain
CRN64_RS01585	COG0539	negative regulation of cytoplasmic translation
CRN64_RS01595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRN64_RS01610	COG2226	methyltransferase
CRN64_RS01615	COG0142	geranyltranstransferase activity
CRN64_RS01625	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRN64_RS01630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CRN64_RS01655	COG2738	Putative neutral zinc metallopeptidase
CRN64_RS01660	COG1694	Mazg nucleotide pyrophosphohydrolase
CRN64_RS01665	COG0438	transferase activity, transferring glycosyl groups
CRN64_RS01670	COG0617	tRNA 3'-terminal CCA addition
CRN64_RS01675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRN64_RS01675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRN64_RS01680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRN64_RS01680	COG1199	ATP-dependent helicase activity
CRN64_RS01685	COG0017	Asparaginyl-tRNA synthetase
CRN64_RS01690	COG3935	DnaD domain protein
CRN64_RS01695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRN64_RS01705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN64_RS01705	COG4499	WXG100 protein secretion system (Wss), protein YukC
CRN64_RS01720	COG4474	Belongs to the UPF0398 family
CRN64_RS01725	COG3599	regulation of cell shape
CRN64_RS01735	COG0116	Belongs to the methyltransferase superfamily
CRN64_RS01745	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CRN64_RS01750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRN64_RS01755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRN64_RS01760	COG0512	Glutamine amidotransferase of anthranilate synthase
CRN64_RS01765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRN64_RS01770	COG0134	indole-3-glycerol-phosphate synthase activity
CRN64_RS01775	COG0135	phosphoribosylanthranilate isomerase activity
CRN64_RS01790	COG2348	transferase activity, transferring amino-acyl groups
CRN64_RS01800	COG0561	phosphatase activity
CRN64_RS01805	COG4607	ABC-type enterochelin transport system periplasmic component
CRN64_RS01815	COG1164	Oligoendopeptidase f
CRN64_RS01825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRN64_RS01830	COG0581	inorganic phosphate transmembrane transporter activity
CRN64_RS01835	COG0573	inorganic phosphate transmembrane transporter activity
CRN64_RS01840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRN64_RS01845	COG2996	Protein conserved in bacteria
CRN64_RS01850	COG0488	(ABC) transporter
CRN64_RS01855	COG0527	aspartate kinase activity
CRN64_RS01860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRN64_RS01865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN64_RS01870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRN64_RS01875	COG2171	N-acyltransferase activity
CRN64_RS01880	COG1473	amidohydrolase
CRN64_RS01900	COG1278	Cold shock
CRN64_RS01910	COG1254	Belongs to the acylphosphatase family
CRN64_RS01920	COG3853	Toxic anion resistance protein (TelA)
CRN64_RS01925	COG1114	Component of the transport system for branched-chain amino acids
CRN64_RS01930	COG4548	von Willebrand factor, type A
CRN64_RS01935	COG0714	Associated with various cellular activities
CRN64_RS01955	COG0567	Dehydrogenase, E1 component
CRN64_RS01960	COG5002	protein histidine kinase activity
CRN64_RS01965	COG0745	RESPONSE REGULATOR receiver
CRN64_RS01970	COG0671	phosphoesterase, PA-phosphatase related
CRN64_RS01975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRN64_RS01985	COG0793	Belongs to the peptidase S41A family
CRN64_RS01990	COG4479	Belongs to the UPF0346 family
CRN64_RS02000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRN64_RS02030	COG1413	lyase activity
CRN64_RS02040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CRN64_RS02045	COG0328	RNA-DNA hybrid ribonuclease activity
CRN64_RS02050	COG1363	Peptidase, m42
CRN64_RS02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS02075	COG3623	hexulose-6-phosphate isomerase
CRN64_RS02095	COG0287	Prephenate dehydrogenase
CRN64_RS02100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRN64_RS02105	COG1942	4-Oxalocrotonate Tautomerase
CRN64_RS02135	COG0392	lysyltransferase activity
CRN64_RS02135	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CRN64_RS02140	COG0628	permease
CRN64_RS02145	COG1115	amino acid carrier protein
CRN64_RS02150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRN64_RS02155	COG0187	DNA topoisomerase II activity
CRN64_RS02160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CRN64_RS02165	COG4841	protein insertion into membrane
CRN64_RS02175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRN64_RS02180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CRN64_RS02185	COG1970	mechanosensitive ion channel activity
CRN64_RS02190	COG0419	ATPase involved in DNA repair
CRN64_RS02200	COG4846	Membrane protein involved in cytochrome C biogenesis
CRN64_RS02205	COG3763	UPF0154 protein
CRN64_RS02210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRN64_RS02215	COG4224	UPF0291 protein
CRN64_RS02225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRN64_RS02230	COG2340	Cysteine-rich secretory protein family
CRN64_RS02240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRN64_RS02255	COG0833	amino acid
CRN64_RS02265	COG0561	phosphatase activity
CRN64_RS02270	COG0083	homoserine kinase activity
CRN64_RS02275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRN64_RS02280	COG0460	homoserine dehydrogenase
CRN64_RS02300	COG1525	nuclease
CRN64_RS02315	COG2197	response regulator
CRN64_RS02320	COG4585	Histidine kinase
CRN64_RS02320	COG2203	Gaf domain
CRN64_RS02330	COG1131	(ABC) transporter
CRN64_RS02335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN64_RS02350	COG0789	Transcriptional regulator
CRN64_RS02355	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CRN64_RS02360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRN64_RS02370	COG1923	regulation of RNA biosynthetic process
CRN64_RS02375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRN64_RS02385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRN64_RS02390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRN64_RS02395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRN64_RS02405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CRN64_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRN64_RS02425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRN64_RS02440	COG4195	phage-related replication protein
CRN64_RS02445	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRN64_RS02450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRN64_RS02450	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRN64_RS02455	COG1692	metallophosphoesterase
CRN64_RS02465	COG1418	mRNA catabolic process
CRN64_RS02470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRN64_RS02475	COG1058	Belongs to the CinA family
CRN64_RS02475	COG1546	Belongs to the CinA family
CRN64_RS02495	COG0300	oxidoreductase activity
CRN64_RS02500	COG0612	Peptidase, M16
CRN64_RS02505	COG0612	Peptidase, M16
CRN64_RS02510	COG2188	Transcriptional regulator
CRN64_RS02515	COG1674	ftsk spoiiie
CRN64_RS02520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CRN64_RS02525	COG1185	polyribonucleotide nucleotidyltransferase activity
CRN64_RS02535	COG0196	riboflavin kinase activity
CRN64_RS02545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRN64_RS02550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRN64_RS02555	COG1358	cellular component organization or biogenesis
CRN64_RS02560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CRN64_RS02565	COG0195	Participates in both transcription termination and antitermination
CRN64_RS02570	COG0779	Required for maturation of 30S ribosomal subunits
CRN64_RS02575	COG2176	DNA-directed DNA polymerase activity
CRN64_RS02580	COG0442	prolyl-tRNA aminoacylation
CRN64_RS02595	COG4589	Belongs to the CDS family
CRN64_RS02600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRN64_RS02605	COG0233	cytoplasmic translational termination
CRN64_RS02610	COG0528	UMP kinase activity
CRN64_RS02615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRN64_RS02620	COG0052	Belongs to the universal ribosomal protein uS2 family
CRN64_RS02625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CRN64_RS02630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CRN64_RS02635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CRN64_RS02640	COG4974	Belongs to the 'phage' integrase family
CRN64_RS02645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CRN64_RS02650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRN64_RS02655	COG0758	DNA mediated transformation
CRN64_RS02665	COG2348	transferase activity, transferring amino-acyl groups
CRN64_RS02670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRN64_RS02675	COG0045	succinate-CoA ligase (ADP-forming) activity
CRN64_RS02680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRN64_RS02690	COG4485	Bacterial membrane protein, YfhO
CRN64_RS02700	COG0335	large ribosomal subunit rRNA binding
CRN64_RS02705	COG0336	Belongs to the RNA methyltransferase TrmD family
CRN64_RS02710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRN64_RS02715	COG0228	four-way junction DNA binding
CRN64_RS02730	COG0183	Belongs to the thiolase family
CRN64_RS02735	COG0318	PFAM AMP-dependent synthetase and ligase
CRN64_RS02745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRN64_RS02750	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CRN64_RS02755	COG0552	protein localization to endoplasmic reticulum
CRN64_RS02760	COG1196	nuclear chromosome segregation
CRN64_RS02765	COG0571	ribonuclease III activity
CRN64_RS02770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRN64_RS02785	COG0416	fatty acid biosynthetic process
CRN64_RS02790	COG1349	DNA-binding transcription factor activity
CRN64_RS02795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRN64_RS02800	COG1461	Dihydroxyacetone kinase
CRN64_RS02805	COG1302	Protein conserved in bacteria
CRN64_RS02810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRN64_RS02820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRN64_RS02835	COG0631	protein serine/threonine phosphatase activity
CRN64_RS02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRN64_RS02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CRN64_RS02850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRN64_RS02860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRN64_RS02865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CRN64_RS02870	COG1758	RNA polymerase activity
CRN64_RS02875	COG0194	GDP metabolic process
CRN64_RS02895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRN64_RS02900	COG0284	orotidine-5'-phosphate decarboxylase activity
CRN64_RS02910	COG0505	Belongs to the CarA family
CRN64_RS02920	COG0540	Belongs to the ATCase OTCase family
CRN64_RS02925	COG2233	PERMEase
CRN64_RS02930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CRN64_RS02935	COG0564	pseudouridine synthase activity
CRN64_RS02940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRN64_RS02950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRN64_RS02955	COG3599	regulation of cell shape
CRN64_RS02960	COG2302	S4 RNA-binding domain
CRN64_RS02965	COG0762	integral membrane protein
CRN64_RS02970	COG1799	cell septum assembly
CRN64_RS02975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRN64_RS02980	COG1496	oxidoreductase activity
CRN64_RS02985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRN64_RS02990	COG0849	cell division
CRN64_RS02995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRN64_RS03000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRN64_RS03005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN64_RS03010	COG0768	penicillin binding
CRN64_RS03015	COG4839	cell division protein FtsL
CRN64_RS03020	COG0275	rRNA processing
CRN64_RS03030	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CRN64_RS03035	COG0454	-acetyltransferase
CRN64_RS03045	COG1011	Hydrolase
CRN64_RS03055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRN64_RS03060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRN64_RS03065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRN64_RS03070	COG1053	succinate dehydrogenase
CRN64_RS03075	COG2009	succinate dehydrogenase
CRN64_RS03080	COG0322	excinuclease ABC activity
CRN64_RS03085	COG3118	belongs to the thioredoxin family
CRN64_RS03090	COG1193	negative regulation of DNA recombination
CRN64_RS03095	COG1796	DNA polymerase
CRN64_RS03095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CRN64_RS03105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CRN64_RS03110	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRN64_RS03120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN64_RS03120	COG0072	phenylalanine-tRNA ligase activity
CRN64_RS03125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRN64_RS03130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN64_RS03135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRN64_RS03150	COG1323	Belongs to the UPF0348 family
CRN64_RS03155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRN64_RS03160	COG0742	ribosomal rna small subunit methyltransferase
CRN64_RS03180	COG3679	Belongs to the UPF0342 family
CRN64_RS03195	COG0109	protoheme IX farnesyltransferase activity
CRN64_RS03200	COG1612	heme a metabolic process
CRN64_RS03210	COG0772	Belongs to the SEDS family
CRN64_RS03215	COG4838	Belongs to the UPF0358 family
CRN64_RS03220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CRN64_RS03230	COG1217	gtp-binding protein TYPA
CRN64_RS03240	COG0483	inositol monophosphate 1-phosphatase activity
CRN64_RS03245	COG4493	Belongs to the UPF0637 family
CRN64_RS03265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRN64_RS03270	COG1177	transmembrane transport
CRN64_RS03290	COG4476	Belongs to the UPF0223 family
CRN64_RS03305	COG0022	dehydrogenase e1 component
CRN64_RS03320	COG0242	peptide deformylase activity
CRN64_RS03325	COG5503	Protein of unknown function (DUF1447)
CRN64_RS03330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CRN64_RS03340	COG0569	domain protein
CRN64_RS03355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRN64_RS03385	COG4172	Belongs to the ABC transporter superfamily
CRN64_RS03390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CRN64_RS03395	COG0151	Belongs to the GarS family
CRN64_RS03400	COG0138	bifunctional purine biosynthesis protein purh
CRN64_RS03410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRN64_RS03420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRN64_RS03425	COG0047	phosphoribosylformylglycinamidine synthase activity
CRN64_RS03430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRN64_RS03435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CRN64_RS03440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CRN64_RS03445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRN64_RS03450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRN64_RS03455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRN64_RS03455	COG1017	nitric oxide dioxygenase activity
CRN64_RS03465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRN64_RS03475	COG1845	cytochrome c oxidase, subunit III
CRN64_RS03480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CRN64_RS03490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRN64_RS03495	COG1316	TRANSCRIPTIONal
CRN64_RS03520	COG3594	Acyltransferase
CRN64_RS03525	COG0436	Aminotransferase
CRN64_RS03530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CRN64_RS03535	COG0596	Alpha beta hydrolase
CRN64_RS03540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CRN64_RS03545	COG1169	isochorismate synthase
CRN64_RS03550	COG1575	Belongs to the MenA family. Type 1 subfamily
CRN64_RS03625	COG4873	Protein conserved in bacteria
CRN64_RS03635	COG0737	Belongs to the 5'-nucleotidase family
CRN64_RS03640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRN64_RS03645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRN64_RS03650	COG0861	Integral membrane protein TerC family
CRN64_RS03665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRN64_RS03670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRN64_RS03675	COG2814	Major facilitator Superfamily
CRN64_RS03680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CRN64_RS03685	COG0789	Transcriptional regulator
CRN64_RS03690	COG4221	oxidoreductase activity
CRN64_RS03700	COG0628	permease
CRN64_RS03710	COG0569	domain protein
CRN64_RS03710	COG0475	glutathione-regulated potassium exporter activity
CRN64_RS03715	COG2239	Acts as a magnesium transporter
CRN64_RS03720	COG0564	pseudouridine synthase activity
CRN64_RS03730	COG2357	RelA SpoT domain protein
CRN64_RS03745	COG2346	COG2346, Truncated hemoglobins
CRN64_RS03750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRN64_RS03755	COG1164	Oligoendopeptidase f
CRN64_RS03770	COG1393	Belongs to the ArsC family
CRN64_RS03775	COG0180	Tryptophanyl-tRNA synthetase
CRN64_RS03780	COG2226	methyltransferase
CRN64_RS03785	COG4166	transmembrane transport
CRN64_RS03790	COG4608	Belongs to the ABC transporter superfamily
CRN64_RS03795	COG0444	Belongs to the ABC transporter superfamily
CRN64_RS03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRN64_RS03805	COG0601	transmembrane transport
CRN64_RS03820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRN64_RS03830	COG0542	response to heat
CRN64_RS03840	COG0561	phosphatase activity
CRN64_RS03845	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRN64_RS03860	COG1074	ATP-dependent DNA helicase activity
CRN64_RS03880	COG0398	Pfam SNARE associated Golgi protein
CRN64_RS03885	COG0166	Belongs to the GPI family
CRN64_RS03890	COG0137	argininosuccinate synthase activity
CRN64_RS03920	COG1902	pentaerythritol trinitrate reductase activity
CRN64_RS03925	COG1098	S1 RNA binding domain
CRN64_RS03930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRN64_RS03940	COG2111	Na H antiporter
CRN64_RS03940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN64_RS03945	COG2111	Na H antiporter
CRN64_RS03950	COG1006	Multisubunit Na H antiporter MnhC subunit
CRN64_RS03955	COG0651	ATP synthesis coupled electron transport
CRN64_RS03960	COG1863	multisubunit Na H antiporter MnhE subunit
CRN64_RS03965	COG2212	antiporter activity
CRN64_RS03970	COG1320	monovalent cation:proton antiporter activity
CRN64_RS03980	COG2050	protein possibly involved in aromatic compounds catabolism
CRN64_RS03985	COG2056	Na+-H+ antiporter family
CRN64_RS03990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRN64_RS03995	COG1252	NADH dehydrogenase
CRN64_RS04005	COG1132	(ABC) transporter
CRN64_RS04015	COG1129	ABC transporter
CRN64_RS04050	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRN64_RS04065	COG0316	Belongs to the HesB IscA family
CRN64_RS04070	COG4844	belongs to the
CRN64_RS04075	COG1252	NADH dehydrogenase
CRN64_RS04080	COG4837	Protein of unknown function (DUF1462)
CRN64_RS04085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CRN64_RS04090	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CRN64_RS04095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRN64_RS04100	COG1696	Membrane protein involved in D-alanine export
CRN64_RS04105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRN64_RS04115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN64_RS04120	COG0647	UMP catabolic process
CRN64_RS04125	COG2445	Protein of unknown function DUF86
CRN64_RS04135	COG4470	Protein conserved in bacteria
CRN64_RS04140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CRN64_RS04145	COG0737	Belongs to the 5'-nucleotidase family
CRN64_RS04150	COG0730	response to heat
CRN64_RS04155	COG1801	Protein of unknown function DUF72
CRN64_RS04160	COG2070	2-Nitropropane dioxygenase
CRN64_RS04165	COG1253	flavin adenine dinucleotide binding
CRN64_RS04325	COG3942	CHAP domain
CRN64_RS04325	COG1388	LysM domain
CRN64_RS04345	COG0719	Fe-S assembly protein
CRN64_RS04350	COG0822	iron-sulfur transferase activity
CRN64_RS04360	COG0719	Fe-S assembly protein
CRN64_RS04365	COG0396	ATPase activity
CRN64_RS04385	COG1464	Belongs to the NlpA lipoprotein family
CRN64_RS04390	COG2011	ABC-type metal ion transport system permease component
CRN64_RS04395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN64_RS04405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CRN64_RS04410	COG0509	glycine decarboxylation via glycine cleavage system
CRN64_RS04415	COG1393	Belongs to the ArsC family
CRN64_RS04420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN64_RS04430	COG0710	3-dehydroquinate dehydratase activity
CRN64_RS04435	COG1764	response to oxidative stress
CRN64_RS04445	COG0588	phosphoglycerate mutase activity
CRN64_RS04480	COG4195	phage-related replication protein
CRN64_RS04495	COG2259	Doxx family
CRN64_RS04500	COG0346	lactoylglutathione lyase activity
CRN64_RS04510	COG1611	Belongs to the LOG family
CRN64_RS04605	COG0557	exoribonuclease II activity
CRN64_RS04610	COG1647	Serine aminopeptidase, S33
CRN64_RS04615	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRN64_RS04625	COG0148	phosphopyruvate hydratase activity
CRN64_RS04630	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CRN64_RS04635	COG0149	triose-phosphate isomerase activity
CRN64_RS04640	COG0126	phosphoglycerate kinase activity
CRN64_RS04660	COG1090	epimerase
CRN64_RS04665	COG0740	serine-type endopeptidase activity
CRN64_RS04675	COG1481	regulation of sporulation
CRN64_RS04680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRN64_RS04685	COG1660	Displays ATPase and GTPase activities
CRN64_RS04690	COG0492	ferredoxin-NADP+ reductase activity
CRN64_RS04705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRN64_RS04710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CRN64_RS04715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRN64_RS04735	COG3942	CHAP domain
CRN64_RS04735	COG1388	LysM domain
CRN64_RS04745	COG0653	protein targeting
CRN64_RS04755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRN64_RS04760	COG1040	competence protein
CRN64_RS04765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CRN64_RS04775	COG1739	Uncharacterized protein family UPF0029
CRN64_RS04780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRN64_RS04785	COG2199	diguanylate cyclase activity
CRN64_RS04800	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRN64_RS04805	COG1929	Belongs to the glycerate kinase type-1 family
CRN64_RS04825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CRN64_RS04835	COG4607	ABC-type enterochelin transport system periplasmic component
CRN64_RS04840	COG4604	ABC transporter, ATP-binding protein
CRN64_RS04845	COG4605	iron ion homeostasis
CRN64_RS04850	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS04855	COG4607	ABC-type enterochelin transport system periplasmic component
CRN64_RS04860	COG4604	ABC transporter, ATP-binding protein
CRN64_RS04870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS04875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN64_RS04880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRN64_RS04885	COG1780	Probably involved in ribonucleotide reductase function
CRN64_RS04895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRN64_RS04900	COG3104	oligopeptide transport
CRN64_RS04905	COG1597	lipid kinase activity
CRN64_RS04915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRN64_RS04920	COG3104	oligopeptide transport
CRN64_RS04925	COG1174	glycine betaine transport
CRN64_RS04935	COG0514	ATP-dependent DNA helicase (RecQ)
CRN64_RS04940	COG0488	(ABC) transporter
CRN64_RS04965	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRN64_RS04975	COG0512	Glutamine amidotransferase of anthranilate synthase
CRN64_RS04975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRN64_RS04980	COG0512	Glutamine amidotransferase of anthranilate synthase
CRN64_RS04980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRN64_RS04990	COG0720	synthase
CRN64_RS05005	COG0463	Glycosyl transferase, family 2
CRN64_RS05010	COG0656	L-ascorbic acid biosynthetic process
CRN64_RS05015	COG1253	flavin adenine dinucleotide binding
CRN64_RS05020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS05020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN64_RS05020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN64_RS05025	COG1105	Belongs to the carbohydrate kinase PfkB family
CRN64_RS05030	COG1349	DNA-binding transcription factor activity
CRN64_RS05035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRN64_RS05060	COG0415	Belongs to the DNA photolyase family
CRN64_RS05065	COG0471	metal ion transport
CRN64_RS05070	COG0039	L-malate dehydrogenase activity
CRN64_RS05080	COG0523	cobalamin synthesis protein
CRN64_RS05090	COG1968	undecaprenyl-diphosphatase activity
CRN64_RS05100	COG1671	Belongs to the UPF0178 family
CRN64_RS05105	COG1611	Belongs to the LOG family
CRN64_RS05130	COG2839	Protein conserved in bacteria
CRN64_RS05135	COG2814	Major facilitator Superfamily
CRN64_RS05140	COG0583	DNA-binding transcription factor activity
CRN64_RS05155	COG0217	transcriptional regulatory protein
CRN64_RS05175	COG1388	LysM domain
CRN64_RS05175	COG3942	CHAP domain
CRN64_RS05180	COG0306	phosphate transporter
CRN64_RS05185	COG1392	Phosphate transport regulator
CRN64_RS05190	COG0577	efflux transmembrane transporter activity
CRN64_RS05195	COG1136	(ABC) transporter
CRN64_RS05200	COG2205	protein histidine kinase activity
CRN64_RS05205	COG0745	RESPONSE REGULATOR receiver
CRN64_RS05210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN64_RS05220	COG0657	acetylesterase activity
CRN64_RS05225	COG3949	Membrane
CRN64_RS05235	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CRN64_RS05240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS05245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS05250	COG1120	ATPase activity
CRN64_RS05255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CRN64_RS05265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN64_RS05275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS05275	COG0463	Glycosyl transferase, family 2
CRN64_RS05280	COG0438	transferase activity, transferring glycosyl groups
CRN64_RS05285	COG1132	(ABC) transporter
CRN64_RS05290	COG1686	Belongs to the peptidase S11 family
CRN64_RS05295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRN64_RS05300	COG1215	transferase activity, transferring glycosyl groups
CRN64_RS05305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS05315	COG1682	transport, permease protein
CRN64_RS05320	COG1134	teichoic acid transport
CRN64_RS05335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CRN64_RS05345	COG1321	iron dependent repressor
CRN64_RS05350	COG1121	(ABC) transporter
CRN64_RS05355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRN64_RS05360	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRN64_RS05370	COG1320	monovalent cation:proton antiporter activity
CRN64_RS05375	COG2212	antiporter activity
CRN64_RS05380	COG1863	multisubunit Na H antiporter MnhE subunit
CRN64_RS05385	COG0651	ATP synthesis coupled electron transport
CRN64_RS05390	COG1006	Multisubunit Na H antiporter MnhC subunit
CRN64_RS05395	COG2111	Na H antiporter
CRN64_RS05400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN64_RS05400	COG2111	Na H antiporter
CRN64_RS05405	COG4974	Belongs to the 'phage' integrase family
CRN64_RS05435	COG0596	Alpha beta hydrolase
CRN64_RS05460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS05465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN64_RS05485	COG0018	arginyl-trna synthetase
CRN64_RS05505	COG1064	alcohol dehydrogenase
CRN64_RS05515	COG1078	dGTPase activity
CRN64_RS05525	COG0655	NAD(P)H dehydrogenase (quinone) activity
CRN64_RS05530	COG0667	Aldo Keto reductase
CRN64_RS05540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN64_RS05545	COG4844	belongs to the
CRN64_RS05565	COG0095	Lipoate-protein ligase
CRN64_RS05575	COG3253	May function as heme-dependent peroxidase
CRN64_RS05605	COG0531	amino acid
CRN64_RS05610	COG2363	Small membrane protein
CRN64_RS05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRN64_RS05655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRN64_RS05660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CRN64_RS05670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRN64_RS05680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS05705	COG0561	phosphatase activity
CRN64_RS05715	COG1428	Deoxynucleoside kinase
CRN64_RS05720	COG1428	Deoxynucleoside kinase
CRN64_RS05740	COG0531	amino acid
CRN64_RS05745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRN64_RS05755	COG1279	arginine transmembrane transporter activity
CRN64_RS05780	COG1473	amidohydrolase
CRN64_RS05785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRN64_RS05800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRN64_RS05810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRN64_RS05815	COG0085	RNA polymerase activity
CRN64_RS05820	COG2813	Specifically methylates the guanine in position
CRN64_RS05825	COG0222	ribosome binding
CRN64_RS05830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRN64_RS05840	COG0081	regulation of translation
CRN64_RS05850	COG0250	Participates in transcription elongation, termination and antitermination
CRN64_RS05855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRN64_RS05860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRN64_RS05870	COG3688	RNA-binding protein containing a PIN domain
CRN64_RS05875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRN64_RS05880	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CRN64_RS05885	COG0215	cysteine-tRNA ligase activity
CRN64_RS05890	COG1045	serine acetyltransferase
CRN64_RS05895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRN64_RS05900	COG4956	integral membrane protein (PIN domain superfamily)
CRN64_RS05905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CRN64_RS05910	COG0542	response to heat
CRN64_RS05915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CRN64_RS05920	COG3880	PFAM UvrB UvrC protein
CRN64_RS05925	COG4463	regulation of RNA biosynthetic process
CRN64_RS05930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN64_RS05935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CRN64_RS05940	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CRN64_RS05945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRN64_RS06030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRN64_RS06040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRN64_RS06045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRN64_RS06055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRN64_RS06065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRN64_RS06080	COG1098	S1 RNA binding domain
CRN64_RS06090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRN64_RS06095	COG3956	TIGRFAM MazG family protein
CRN64_RS06100	COG2244	polysaccharide biosynthetic process
CRN64_RS06105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRN64_RS06110	COG0193	aminoacyl-tRNA hydrolase activity
CRN64_RS06120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRN64_RS06125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRN64_RS06135	COG0251	oxidation-reduction process
CRN64_RS06140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRN64_RS06145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CRN64_RS06150	COG4466	Protein conserved in bacteria
CRN64_RS06155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRN64_RS06160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CRN64_RS06165	COG0084	hydrolase, TatD family'
CRN64_RS06170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN64_RS06170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRN64_RS06175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRN64_RS06185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRN64_RS06195	COG1774	PSP1 C-terminal conserved region
CRN64_RS06200	COG0470	DNA polymerase III
CRN64_RS06205	COG3870	Protein conserved in bacteria
CRN64_RS06210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRN64_RS06215	COG1982	Orn Lys Arg decarboxylase major
CRN64_RS06250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRN64_RS06260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRN64_RS06275	COG2188	Transcriptional regulator
CRN64_RS06280	COG0366	Alpha amylase catalytic
CRN64_RS06285	COG1263	PTS System
CRN64_RS06285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS06295	COG0493	'glutamate synthase
CRN64_RS06300	COG0067	glutamate synthase
CRN64_RS06300	COG0069	glutamate synthase activity
CRN64_RS06300	COG0070	glutamate synthase
CRN64_RS06305	COG0583	DNA-binding transcription factor activity
CRN64_RS06335	COG1464	Belongs to the NlpA lipoprotein family
CRN64_RS06340	COG2011	ABC-type metal ion transport system permease component
CRN64_RS06345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN64_RS06350	COG1132	(ABC) transporter
CRN64_RS06355	COG1132	(ABC) transporter
CRN64_RS06355	COG2375	cellular response to nickel ion
CRN64_RS06360	COG0626	cystathionine gamma-synthase activity
CRN64_RS06365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRN64_RS06375	COG0733	neurotransmitter:sodium symporter activity
CRN64_RS06395	COG5609	conserved protein (DUF2294)
CRN64_RS06400	COG3002	Belongs to the UPF0753 family
CRN64_RS06405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRN64_RS06415	COG0523	cobalamin synthesis protein
CRN64_RS06435	COG0519	Catalyzes the synthesis of GMP from XMP
CRN64_RS06435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRN64_RS06440	COG0517	IMP dehydrogenase activity
CRN64_RS06440	COG0516	GMP reductase activity
CRN64_RS06445	COG2233	PERMEase
CRN64_RS06450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRN64_RS06470	COG1823	symporter activity
CRN64_RS06480	COG0778	Nitroreductase
CRN64_RS06490	COG0450	alkyl hydroperoxide reductase
CRN64_RS06495	COG3634	alkyl hydroperoxide reductase activity
CRN64_RS06510	COG0406	alpha-ribazole phosphatase activity
CRN64_RS06555	COG3728	DNA packaging
CRN64_RS06555	COG5484	DNA packaging
CRN64_RS06625	COG0582	viral genome integration into host DNA
CRN64_RS06630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRN64_RS06640	COG0360	Binds together with S18 to 16S ribosomal RNA
CRN64_RS06655	COG0012	GTP binding
CRN64_RS06660	COG4481	Protein conserved in bacteria
CRN64_RS06665	COG0668	transmembrane transport
CRN64_RS06670	COG1475	DNA binding
CRN64_RS06675	COG0626	cystathionine gamma-synthase activity
CRN64_RS06680	COG0626	cystathionine gamma-synthase activity
CRN64_RS06685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CRN64_RS06685	COG0646	methionine synthase
CRN64_RS06690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRN64_RS06715	COG0577	efflux transmembrane transporter activity
CRN64_RS06720	COG1136	(ABC) transporter
CRN64_RS06740	COG2205	protein histidine kinase activity
CRN64_RS06755	COG0745	RESPONSE REGULATOR receiver
CRN64_RS06780	COG3878	Protein conserved in bacteria
CRN64_RS06785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRN64_RS06790	COG2271	Major facilitator Superfamily
CRN64_RS06805	COG1136	(ABC) transporter
CRN64_RS06810	COG0577	efflux transmembrane transporter activity
CRN64_RS06820	COG1396	sequence-specific DNA binding
CRN64_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS06845	COG1063	alcohol dehydrogenase
CRN64_RS06865	COG1475	DNA binding
CRN64_RS06875	COG0445	tRNA wobble uridine modification
CRN64_RS06880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRN64_RS06885	COG0594	ribonuclease P activity
CRN64_RS06895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRN64_RS06900	COG0592	DNA-directed DNA polymerase activity
CRN64_RS06905	COG2501	S4 domain
CRN64_RS06910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRN64_RS06915	COG0187	DNA topoisomerase II activity
CRN64_RS06920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRN64_RS06925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRN64_RS06935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRN64_RS06945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRN64_RS06955	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CRN64_RS06960	COG0359	binds to the 23S rRNA
CRN64_RS06965	COG0305	Participates in initiation and elongation during chromosome replication
CRN64_RS06970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRN64_RS06985	COG0745	RESPONSE REGULATOR receiver
CRN64_RS06990	COG5002	protein histidine kinase activity
CRN64_RS06995	COG4863	YycH protein
CRN64_RS07030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRN64_RS07035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CRN64_RS07045	COG1522	sequence-specific DNA binding
CRN64_RS07070	COG1073	alpha beta
CRN64_RS07100	COG1129	ABC transporter
CRN64_RS07135	COG5002	protein histidine kinase activity
CRN64_RS07140	COG0745	RESPONSE REGULATOR receiver
CRN64_RS07155	COG1131	(ABC) transporter
CRN64_RS07205	COG2188	Transcriptional regulator
CRN64_RS07210	COG2222	sugar isomerase
CRN64_RS07215	COG3684	Belongs to the aldolase LacD family
CRN64_RS07220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS07225	COG3715	PTS system
CRN64_RS07230	COG3716	PTS system mannose fructose sorbose family IID component
CRN64_RS07245	COG0745	RESPONSE REGULATOR receiver
CRN64_RS07250	COG2205	protein histidine kinase activity
CRN64_RS07260	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRN64_RS07265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRN64_RS07290	COG1129	ABC transporter
CRN64_RS07325	COG4509	Sortase family
CRN64_RS07335	COG3942	CHAP domain
CRN64_RS07335	COG1705	Flagellar rod assembly protein muramidase FlgJ
CRN64_RS07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS07345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS07350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN64_RS07355	COG2808	Putative FMN-binding domain
CRN64_RS07365	COG1846	Transcriptional regulator
CRN64_RS07380	COG3842	ATPase activity
CRN64_RS07385	COG4209	transmembrane transport
CRN64_RS07395	COG0395	ABC-type sugar transport system, permease component
CRN64_RS07405	COG0534	Mate efflux family protein
CRN64_RS07410	COG1349	DNA-binding transcription factor activity
CRN64_RS07420	COG5002	protein histidine kinase activity
CRN64_RS07455	COG0583	DNA-binding transcription factor activity
CRN64_RS07460	COG3842	ATPase activity
CRN64_RS07465	COG1840	ABC-type Fe3 transport system, periplasmic component
CRN64_RS07470	COG1177	transmembrane transport
CRN64_RS07475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRN64_RS07480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRN64_RS07490	COG1114	Component of the transport system for branched-chain amino acids
CRN64_RS07500	COG0464	growth
CRN64_RS07505	COG0561	phosphatase activity
CRN64_RS07510	COG2814	Major facilitator Superfamily
CRN64_RS07525	COG0601	transmembrane transport
CRN64_RS07535	COG0444	Belongs to the ABC transporter superfamily
CRN64_RS07540	COG1124	(ABC) transporter
CRN64_RS07555	COG0693	protein deglycase activity
CRN64_RS07560	COG0531	amino acid
CRN64_RS07565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRN64_RS07565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRN64_RS07570	COG0505	Belongs to the CarA family
CRN64_RS07575	COG0657	acetylesterase activity
CRN64_RS07615	COG1033	growth of symbiont in host cell
CRN64_RS07615	COG2409	Drug exporters of the RND superfamily
CRN64_RS07635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRN64_RS07650	COG1131	(ABC) transporter
CRN64_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS07670	COG1278	Cold shock
CRN64_RS07685	COG2311	Membrane
CRN64_RS07690	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CRN64_RS07700	COG1233	COG1233 Phytoene dehydrogenase and related
CRN64_RS07720	COG2814	Major facilitator Superfamily
CRN64_RS07735	COG1131	(ABC) transporter
CRN64_RS07760	COG2264	protein methyltransferase activity
CRN64_RS07765	COG0747	negative chemotaxis
CRN64_RS07770	COG0601	transmembrane transport
CRN64_RS07780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN64_RS07785	COG1124	(ABC) transporter
CRN64_RS07790	COG3961	Belongs to the TPP enzyme family
CRN64_RS07805	COG1131	(ABC) transporter
CRN64_RS07815	COG2353	YceI-like domain
CRN64_RS07820	COG1288	antiporter activity
CRN64_RS07830	COG2814	Major facilitator Superfamily
CRN64_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS07860	COG2190	(PTS) system
CRN64_RS07860	COG1263	PTS System
CRN64_RS07860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS07865	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS07895	COG0431	NADPH-dependent FMN reductase
CRN64_RS07895	COG1053	succinate dehydrogenase
CRN64_RS07895	COG3976	FMN-binding domain protein
CRN64_RS07910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CRN64_RS07920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN64_RS07925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CRN64_RS07930	COG0022	dehydrogenase e1 component
CRN64_RS07940	COG1695	Transcriptional regulator
CRN64_RS07965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS07965	COG3711	transcriptional antiterminator
CRN64_RS07970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN64_RS07970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS07970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRN64_RS07975	COG1482	cell wall glycoprotein biosynthetic process
CRN64_RS07980	COG2124	cytochrome p450
CRN64_RS07990	COG1846	Transcriptional regulator
CRN64_RS07995	COG2814	Major facilitator Superfamily
CRN64_RS08020	COG0706	membrane insertase activity
CRN64_RS08030	COG0531	amino acid
CRN64_RS08085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRN64_RS08105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRN64_RS08115	COG0363	glucosamine-6-phosphate deaminase activity
CRN64_RS08120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CRN64_RS08135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRN64_RS08140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRN64_RS08145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRN64_RS08180	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CRN64_RS08200	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CRN64_RS08205	COG3711	transcriptional antiterminator
CRN64_RS08205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS08210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRN64_RS08225	COG1054	Belongs to the UPF0176 family
CRN64_RS08230	COG3386	PFAM SMP-30 Gluconolaconase
CRN64_RS08245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN64_RS08255	COG1122	ATPase activity
CRN64_RS08265	COG1476	TRANSCRIPTIONal
CRN64_RS08300	COG1705	Flagellar rod assembly protein muramidase FlgJ
CRN64_RS08300	COG3942	CHAP domain
CRN64_RS08320	COG2235	arginine
CRN64_RS08330	COG2843	Capsule synthesis protein
CRN64_RS08335	COG4195	phage-related replication protein
CRN64_RS08340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CRN64_RS08380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRN64_RS08415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRN64_RS08420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CRN64_RS08425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRN64_RS08430	COG1785	Belongs to the alkaline phosphatase family
CRN64_RS08445	COG2205	protein histidine kinase activity
CRN64_RS08450	COG1136	(ABC) transporter
CRN64_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS08485	COG3266	domain, Protein
CRN64_RS08485	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CRN64_RS08485	COG3266	domain, Protein
CRN64_RS08485	COG4932	domain protein
CRN64_RS08485	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CRN64_RS08485	COG4932	domain protein
CRN64_RS08495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CRN64_RS08500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN64_RS08515	COG0730	response to heat
CRN64_RS08520	COG2046	Belongs to the sulfate adenylyltransferase family
CRN64_RS08525	COG0529	Catalyzes the synthesis of activated sulfate
CRN64_RS08540	COG1328	CTP reductase activity
CRN64_RS08545	COG0602	queuosine metabolic process
CRN64_RS08550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRN64_RS08565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CRN64_RS08570	COG1510	regulation of RNA biosynthetic process
CRN64_RS08575	COG1012	belongs to the aldehyde dehydrogenase family
CRN64_RS08580	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CRN64_RS08585	COG1473	amidohydrolase
CRN64_RS08600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRN64_RS08605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRN64_RS08605	COG0574	Belongs to the PEP-utilizing enzyme family
CRN64_RS08610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CRN64_RS08620	COG2188	Transcriptional regulator
CRN64_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS08625	COG1263	PTS System
CRN64_RS08625	COG2190	(PTS) system
CRN64_RS08630	COG2723	6-phospho-beta-galactosidase activity
CRN64_RS08640	COG0583	DNA-binding transcription factor activity
CRN64_RS08655	COG3588	fructose-bisphosphate aldolase
CRN64_RS08670	COG1464	Belongs to the NlpA lipoprotein family
CRN64_RS08680	COG0463	Glycosyl transferase, family 2
CRN64_RS08690	COG1215	transferase activity, transferring glycosyl groups
CRN64_RS08690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS08700	COG0531	amino acid
CRN64_RS08705	COG0583	DNA-binding transcription factor activity
CRN64_RS08710	COG0028	Belongs to the TPP enzyme family
CRN64_RS08715	COG3527	Alpha-acetolactate decarboxylase
CRN64_RS08720	COG1620	l-lactate permease
CRN64_RS08740	COG0167	dihydroorotate dehydrogenase activity
CRN64_RS08745	COG3001	Fructosamine kinase
CRN64_RS08750	COG0596	Alpha beta hydrolase
CRN64_RS08800	COG2814	Major facilitator Superfamily
CRN64_RS08810	COG1113	amino acid transport
CRN64_RS08825	COG3189	MarR family transcriptional regulator
CRN64_RS08845	COG0436	Aminotransferase
CRN64_RS08860	COG2608	mercury ion transmembrane transporter activity
CRN64_RS08865	COG2217	Heavy metal translocating P-type atpase
CRN64_RS08875	COG0110	maltose O-acetyltransferase activity
CRN64_RS08880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS08885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRN64_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
CRN64_RS08900	COG2409	Drug exporters of the RND superfamily
CRN64_RS08910	COG0598	Magnesium transport protein CorA
CRN64_RS08915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRN64_RS08940	COG1131	(ABC) transporter
CRN64_RS08950	COG3425	synthase
CRN64_RS08965	COG1388	LysM domain
CRN64_RS08965	COG3942	CHAP domain
CRN64_RS08975	COG0583	DNA-binding transcription factor activity
CRN64_RS08980	COG1380	Effector of murein hydrolase LrgA
CRN64_RS08985	COG1346	cytolysis
CRN64_RS08990	COG0028	Belongs to the TPP enzyme family
CRN64_RS09005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRN64_RS09010	COG0039	L-malate dehydrogenase activity
CRN64_RS09015	COG0657	acetylesterase activity
CRN64_RS09025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRN64_RS09050	COG1070	Carbohydrate kinase
CRN64_RS09060	COG1760	l-serine dehydratase
CRN64_RS09065	COG1760	l-serine dehydratase
CRN64_RS09080	COG3764	Sortase (surface protein transpeptidase)
CRN64_RS09090	COG0561	phosphatase activity
CRN64_RS09095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN64_RS09100	COG0778	Nitroreductase
CRN64_RS09110	COG1012	belongs to the aldehyde dehydrogenase family
CRN64_RS09115	COG2514	catechol 2,3-dioxygenase activity
CRN64_RS09120	COG2388	GCN5-related N-acetyl-transferase
CRN64_RS09140	COG1846	Transcriptional regulator
CRN64_RS09145	COG0346	lactoylglutathione lyase activity
CRN64_RS09150	COG0346	lactoylglutathione lyase activity
CRN64_RS09155	COG0400	carboxylic ester hydrolase activity
CRN64_RS09160	COG3949	Membrane
CRN64_RS09170	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CRN64_RS09175	COG0586	Pfam SNARE associated Golgi protein
CRN64_RS09185	COG2022	thiamine diphosphate biosynthetic process
CRN64_RS09205	COG2271	Major facilitator Superfamily
CRN64_RS09220	COG4876	unkown
CRN64_RS09225	COG2357	RelA SpoT domain protein
CRN64_RS09240	COG1802	Transcriptional regulator
CRN64_RS09245	COG1070	Carbohydrate kinase
CRN64_RS09250	COG2610	gluconate transmembrane transporter activity
CRN64_RS09255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRN64_RS09270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRN64_RS09275	COG0438	transferase activity, transferring glycosyl groups
CRN64_RS09280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRN64_RS09295	COG4221	oxidoreductase activity
CRN64_RS09300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRN64_RS09305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRN64_RS09315	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CRN64_RS09320	COG1363	Peptidase, m42
CRN64_RS09340	COG3639	organic phosphonate transmembrane transporter activity
CRN64_RS09345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CRN64_RS09360	COG0737	Belongs to the 5'-nucleotidase family
CRN64_RS09365	COG0069	glutamate synthase activity
CRN64_RS09380	COG4619	ABC transporter
CRN64_RS09385	COG0390	transport system, permease component
CRN64_RS09390	COG2205	protein histidine kinase activity
CRN64_RS09395	COG0745	RESPONSE REGULATOR receiver
CRN64_RS09405	COG2814	Major facilitator Superfamily
CRN64_RS09410	COG2272	Belongs to the type-B carboxylesterase lipase family
CRN64_RS09415	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CRN64_RS09420	COG1063	alcohol dehydrogenase
CRN64_RS09440	COG1174	glycine betaine transport
CRN64_RS09470	COG1346	cytolysis
CRN64_RS09475	COG1380	Effector of murein hydrolase LrgA
CRN64_RS09485	COG3279	Response regulator of the LytR AlgR family
CRN64_RS09490	COG3275	phosphorelay sensor kinase activity
CRN64_RS09500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CRN64_RS09505	COG0456	acetyltransferase
CRN64_RS09515	COG0706	membrane insertase activity
CRN64_RS09525	COG0531	amino acid
CRN64_RS09545	COG1113	amino acid transport
CRN64_RS09565	COG2814	Major facilitator Superfamily
CRN64_RS09575	COG1929	Belongs to the glycerate kinase type-1 family
CRN64_RS09585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRN64_RS09590	COG0741	lytic transglycosylase activity
CRN64_RS09595	COG0588	phosphoglycerate mutase activity
CRN64_RS09605	COG2814	Major facilitator Superfamily
CRN64_RS09610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRN64_RS09615	COG0765	amino acid transport
CRN64_RS09620	COG1126	abc transporter atp-binding protein
CRN64_RS09660	COG1131	(ABC) transporter
CRN64_RS09670	COG2116	formate transmembrane transporter activity
CRN64_RS09680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRN64_RS09685	COG2146	nitrite reductase [NAD(P)H] activity
CRN64_RS09695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CRN64_RS09700	COG1140	nitrate reductase beta subunit
CRN64_RS09710	COG2181	nitrate reductase activity
CRN64_RS09720	COG4585	Histidine kinase
CRN64_RS09730	COG2223	nitrite transmembrane transporter activity
CRN64_RS09735	COG1846	Transcriptional regulator
CRN64_RS09775	COG1263	PTS System
CRN64_RS09775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS09800	COG0534	Mate efflux family protein
CRN64_RS09810	COG1124	(ABC) transporter
CRN64_RS09815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRN64_RS09825	COG0601	transmembrane transport
CRN64_RS09835	COG0829	nickel cation binding
CRN64_RS09850	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CRN64_RS09855	COG0804	urea catabolic process
CRN64_RS09865	COG0831	urea catabolic process
CRN64_RS09870	COG4413	Urea transporter
CRN64_RS09880	COG4716	Myosin-crossreactive antigen
CRN64_RS09885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRN64_RS09890	COG2962	Rard protein
CRN64_RS09935	COG2814	Major facilitator Superfamily
CRN64_RS09940	COG0583	DNA-binding transcription factor activity
CRN64_RS09980	COG2314	TM2 domain
CRN64_RS09985	COG0492	ferredoxin-NADP+ reductase activity
CRN64_RS10000	COG0604	alcohol dehydrogenase
CRN64_RS10005	COG2822	iron ion transport
CRN64_RS10010	COG2837	iron assimilation
CRN64_RS10015	COG0672	)-iron permease
CRN64_RS10020	COG0805	protein transport
CRN64_RS10025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRN64_RS10030	COG0456	acetyltransferase
CRN64_RS10040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRN64_RS10045	COG1620	l-lactate permease
CRN64_RS10050	COG0297	glycogen (starch) synthase activity
CRN64_RS10055	COG0579	oxidoreductase
CRN64_RS10105	COG2814	Major facilitator Superfamily
CRN64_RS10115	COG1566	PFAM secretion protein HlyD family protein
CRN64_RS10120	COG2814	Major facilitator Superfamily
CRN64_RS10145	COG0598	Magnesium transport protein CorA
CRN64_RS10150	COG1304	FMN binding
CRN64_RS10155	COG2094	Belongs to the DNA glycosylase MPG family
CRN64_RS10165	COG2017	converts alpha-aldose to the beta-anomer
CRN64_RS10170	COG2258	MOSC domain
CRN64_RS10175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CRN64_RS10180	COG1266	CAAX protease self-immunity
CRN64_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
CRN64_RS10215	COG1737	Transcriptional regulator
CRN64_RS10220	COG1263	PTS System
CRN64_RS10220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS10230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRN64_RS10250	COG1113	amino acid transport
CRN64_RS10255	COG1737	Transcriptional regulator
CRN64_RS10260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRN64_RS10260	COG1263	PTS System
CRN64_RS10265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CRN64_RS10275	COG1349	DNA-binding transcription factor activity
CRN64_RS10285	COG1316	TRANSCRIPTIONal
CRN64_RS10310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRN64_RS10315	COG2076	Multidrug Resistance protein
CRN64_RS10320	COG2076	Multidrug Resistance protein
CRN64_RS10325	COG3942	CHAP domain
CRN64_RS10340	COG1757	Na H antiporter
CRN64_RS10345	COG3942	CHAP domain
CRN64_RS10375	COG1960	acyl-CoA dehydrogenase activity
CRN64_RS10380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN64_RS10390	COG1268	BioY protein
CRN64_RS10400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRN64_RS10405	COG0725	ABC transporter, periplasmic molybdate-binding protein
CRN64_RS10410	COG4149	molybdate abc transporter
CRN64_RS10415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CRN64_RS10420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CRN64_RS10455	COG0746	molybdenum cofactor guanylyltransferase activity
CRN64_RS10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRN64_RS10485	COG2348	transferase activity, transferring amino-acyl groups
CRN64_RS10490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRN64_RS10520	COG2252	PERMEase
CRN64_RS10535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRN64_RS10540	COG0088	Forms part of the polypeptide exit tunnel
CRN64_RS10545	COG0089	rRNA binding
CRN64_RS10550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CRN64_RS10555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRN64_RS10565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRN64_RS10570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRN64_RS10580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRN64_RS10590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRN64_RS10605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRN64_RS10610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRN64_RS10615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRN64_RS10620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRN64_RS10625	COG1841	ribosomal large subunit assembly
CRN64_RS10635	COG0201	protein transport
CRN64_RS10640	COG0563	adenylate kinase activity
CRN64_RS10645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRN64_RS10650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRN64_RS10655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRN64_RS10665	COG0202	RNA polymerase activity
CRN64_RS10670	COG0203	ribosomal protein L17
CRN64_RS10680	COG1122	ATPase activity
CRN64_RS10690	COG0101	tRNA pseudouridine synthase activity
CRN64_RS10695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRN64_RS10715	COG1131	(ABC) transporter
CRN64_RS10725	COG1131	(ABC) transporter
CRN64_RS10735	COG1309	transcriptional regulator
CRN64_RS10780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CRN64_RS10785	COG1349	DNA-binding transcription factor activity
CRN64_RS10790	COG0698	ribose 5-phosphate isomerase
CRN64_RS10795	COG0698	ribose 5-phosphate isomerase
CRN64_RS10800	COG1105	Belongs to the carbohydrate kinase PfkB family
CRN64_RS10805	COG3684	Belongs to the aldolase LacD family
CRN64_RS10810	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRN64_RS10815	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN64_RS10815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRN64_RS10830	COG2130	NADP-dependent
CRN64_RS10835	COG0604	alcohol dehydrogenase
CRN64_RS10865	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CRN64_RS10870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS10875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRN64_RS10880	COG3314	Sporulation integral membrane protein YlbJ
CRN64_RS10890	COG1988	membrane-bound metal-dependent
CRN64_RS10895	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CRN64_RS10900	COG1272	protein, Hemolysin III
CRN64_RS10915	COG2814	Major facilitator Superfamily
CRN64_RS10920	COG0489	protein tyrosine kinase activity
CRN64_RS10990	COG0561	phosphatase activity
CRN64_RS11010	COG0640	Transcriptional regulator
CRN64_RS11015	COG0702	epimerase
CRN64_RS11020	COG1482	cell wall glycoprotein biosynthetic process
CRN64_RS11040	COG0783	Belongs to the Dps family
CRN64_RS11045	COG0813	purine-nucleoside phosphorylase activity
CRN64_RS11050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CRN64_RS11055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CRN64_RS11060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRN64_RS11090	COG1854	S-ribosylhomocysteine lyase activity
CRN64_RS11110	COG5146	pantothenate kinase activity
CRN64_RS11120	COG3343	RNA polymerase activity
CRN64_RS11125	COG0504	CTP synthase activity
CRN64_RS11135	COG0191	fructose-bisphosphate aldolase activity
CRN64_RS11140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRN64_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
CRN64_RS11155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRN64_RS11160	COG0254	rRNA binding
CRN64_RS11170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRN64_RS11175	COG2890	protein-(glutamine-N5) methyltransferase activity
CRN64_RS11180	COG0009	L-threonylcarbamoyladenylate synthase
CRN64_RS11190	COG4475	Protein of unknown function (DUF436)
CRN64_RS11195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRN64_RS11210	COG0356	it plays a direct role in the translocation of protons across the membrane
CRN64_RS11215	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRN64_RS11220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRN64_RS11225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRN64_RS11235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRN64_RS11240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRN64_RS11250	COG4836	Membrane
CRN64_RS11255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRN64_RS11260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRN64_RS11290	COG0629	single-stranded DNA binding
CRN64_RS11300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CRN64_RS11310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CRN64_RS11315	COG0352	thiamine-phosphate diphosphorylase activity
CRN64_RS11320	COG0706	membrane insertase activity
CRN64_RS11325	COG1418	mRNA catabolic process
CRN64_RS11330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRN64_RS11335	COG1937	Protein conserved in bacteria
CRN64_RS11355	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRN64_RS11360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRN64_RS11365	COG0513	Belongs to the DEAD box helicase family
CRN64_RS11375	COG3428	Bacterial PH domain
CRN64_RS11385	COG0736	holo-[acyl-carrier-protein] synthase activity
CRN64_RS11400	COG2337	Toxic component of a toxin-antitoxin (TA) module
CRN64_RS11405	COG2208	phosphoserine phosphatase activity
CRN64_RS11420	COG1191	sigma factor activity
CRN64_RS11425	COG2183	response to ionizing radiation
CRN64_RS11465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRN64_RS11475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRN64_RS11485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRN64_RS11490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRN64_RS11500	COG0028	Belongs to the TPP enzyme family
CRN64_RS11510	COG0802	atpase or kinase
CRN64_RS11515	COG1214	PFAM Peptidase M22, glycoprotease
CRN64_RS11520	COG0456	acetyltransferase
CRN64_RS11525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRN64_RS11530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRN64_RS11535	COG0488	(ABC) transporter
CRN64_RS11540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CRN64_RS11550	COG2391	methyltransferase activity
CRN64_RS11555	COG0425	Belongs to the sulfur carrier protein TusA family
CRN64_RS11560	COG0004	ammonium transporteR
CRN64_RS11565	COG1609	Transcriptional regulator
CRN64_RS11570	COG1621	beta-fructofuranosidase activity
CRN64_RS11575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRN64_RS11585	COG3290	protein histidine kinase activity
CRN64_RS11595	COG4512	PFAM Accessory gene regulator B
CRN64_RS11600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRN64_RS11625	COG0459	protein refolding
CRN64_RS11630	COG0582	viral genome integration into host DNA
CRN64_RS11700	COG3728	DNA packaging
CRN64_RS11700	COG5484	DNA packaging
CRN64_RS11720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRN64_RS11725	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRN64_RS11730	COG0436	Aminotransferase
CRN64_RS11745	COG1725	Transcriptional regulator
CRN64_RS11750	COG0842	Transport permease protein
CRN64_RS11750	COG1129	ABC transporter
CRN64_RS11760	COG1131	(ABC) transporter
CRN64_RS11800	COG2706	6-phosphogluconolactonase activity
CRN64_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
CRN64_RS11810	COG1227	inorganic diphosphatase activity
CRN64_RS11815	COG1335	isochorismatase
CRN64_RS11830	COG0077	Prephenate dehydratase
CRN64_RS11840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CRN64_RS11845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRN64_RS11850	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CRN64_RS11860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRN64_RS11865	COG4496	protein, YerC YecD
CRN64_RS11870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CRN64_RS11880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRN64_RS11885	COG4851	CamS sex pheromone cAM373 precursor
CRN64_RS11895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRN64_RS11905	COG0154	amidase activity
CRN64_RS11910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRN64_RS11915	COG1597	lipid kinase activity
CRN64_RS11920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRN64_RS11945	COG1528	Iron-storage protein
CRN64_RS11965	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRN64_RS11970	COG4129	membrane
CRN64_RS11975	COG0024	Methionine aminopeptidase
CRN64_RS12000	COG1295	ribonuclease BN
CRN64_RS12010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRN64_RS12015	COG4840	Belongs to the UPF0435 family
CRN64_RS12020	COG2309	aminopeptidase activity
CRN64_RS12025	COG1607	acyl-coa hydrolase
CRN64_RS12030	COG0535	radical SAM domain protein
CRN64_RS12040	COG0693	protein deglycase activity
CRN64_RS12045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRN64_RS12050	COG2137	regulation of response to DNA damage stimulus
CRN64_RS12060	COG1134	teichoic acid transport
CRN64_RS12060	COG1388	LysM domain
CRN64_RS12070	COG1988	membrane-bound metal-dependent
CRN64_RS12075	COG1194	a g-specific adenine glycosylase
CRN64_RS12080	COG3557	Belongs to the UPF0374 family
CRN64_RS12090	COG4129	membrane
CRN64_RS12095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRN64_RS12100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRN64_RS12110	COG0735	belongs to the Fur family
CRN64_RS12275	COG0765	amino acid transport
CRN64_RS12285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRN64_RS12295	COG0363	glucosamine-6-phosphate deaminase activity
CRN64_RS12310	COG0114	fumarate hydratase activity
CRN64_RS12315	COG0564	pseudouridine synthase activity
CRN64_RS12320	COG2203	Gaf domain
CRN64_RS12320	COG4585	Histidine kinase
CRN64_RS12325	COG2197	response regulator
CRN64_RS12340	COG3679	Belongs to the UPF0342 family
CRN64_RS12345	COG0420	3'-5' exonuclease activity