locus-tag	class	description
SLGD_RS00005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SLGD_RS00015	COG1522	sequence-specific DNA binding
SLGD_RS00035	COG1073	alpha beta
SLGD_RS00055	COG1129	ABC transporter
SLGD_RS00095	COG0745	RESPONSE REGULATOR receiver
SLGD_RS00110	COG1131	(ABC) transporter
SLGD_RS00115	COG1518	maintenance of DNA repeat elements
SLGD_RS00120	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SLGD_RS00125	COG1353	crispr-associated protein
SLGD_RS00130	COG1421	Csm2 Type III-A
SLGD_RS00135	COG1337	RAMP superfamily
SLGD_RS00140	COG1567	CRISPR-associated RAMP protein, Csm4 family
SLGD_RS00145	COG1332	CRISPR-associated RAMP protein, Csm5 family
SLGD_RS00225	COG2188	Transcriptional regulator
SLGD_RS00230	COG2222	sugar isomerase
SLGD_RS00235	COG3684	Belongs to the aldolase LacD family
SLGD_RS00240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS00245	COG3715	PTS system
SLGD_RS00250	COG3716	PTS system mannose fructose sorbose family IID component
SLGD_RS00265	COG0745	RESPONSE REGULATOR receiver
SLGD_RS00270	COG2205	protein histidine kinase activity
SLGD_RS00280	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SLGD_RS00285	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SLGD_RS00310	COG1129	ABC transporter
SLGD_RS00345	COG4509	Sortase family
SLGD_RS00355	COG1705	Flagellar rod assembly protein muramidase FlgJ
SLGD_RS00355	COG3942	CHAP domain
SLGD_RS00360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS00370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLGD_RS00375	COG2808	Putative FMN-binding domain
SLGD_RS00385	COG1846	Transcriptional regulator
SLGD_RS00400	COG3842	ATPase activity
SLGD_RS00405	COG4209	transmembrane transport
SLGD_RS00415	COG0395	ABC-type sugar transport system, permease component
SLGD_RS00435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SLGD_RS00460	COG1129	ABC transporter
SLGD_RS00495	COG4509	Sortase family
SLGD_RS00505	COG3942	CHAP domain
SLGD_RS00505	COG1705	Flagellar rod assembly protein muramidase FlgJ
SLGD_RS00510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS00515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS00520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLGD_RS00525	COG2808	Putative FMN-binding domain
SLGD_RS00535	COG1846	Transcriptional regulator
SLGD_RS00550	COG3842	ATPase activity
SLGD_RS00555	COG4209	transmembrane transport
SLGD_RS00565	COG0395	ABC-type sugar transport system, permease component
SLGD_RS00575	COG0534	Mate efflux family protein
SLGD_RS00580	COG1349	DNA-binding transcription factor activity
SLGD_RS00590	COG5002	protein histidine kinase activity
SLGD_RS00625	COG0583	DNA-binding transcription factor activity
SLGD_RS00630	COG3842	ATPase activity
SLGD_RS00635	COG1840	ABC-type Fe3 transport system, periplasmic component
SLGD_RS00640	COG1177	transmembrane transport
SLGD_RS00645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SLGD_RS00650	COG1414	Transcriptional regulator
SLGD_RS00660	COG0800	Aldolase
SLGD_RS00665	COG4948	Mandelate Racemase Muconate Lactonizing
SLGD_RS00670	COG2610	gluconate transmembrane transporter activity
SLGD_RS00685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLGD_RS00695	COG1114	Component of the transport system for branched-chain amino acids
SLGD_RS00705	COG0464	growth
SLGD_RS00710	COG0561	phosphatase activity
SLGD_RS00715	COG2814	Major facilitator Superfamily
SLGD_RS00730	COG0601	transmembrane transport
SLGD_RS00740	COG0444	Belongs to the ABC transporter superfamily
SLGD_RS00745	COG1124	(ABC) transporter
SLGD_RS00760	COG0693	protein deglycase activity
SLGD_RS00765	COG0531	amino acid
SLGD_RS00770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLGD_RS00770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLGD_RS00775	COG0505	Belongs to the CarA family
SLGD_RS00780	COG0657	acetylesterase activity
SLGD_RS00820	COG2409	Drug exporters of the RND superfamily
SLGD_RS00820	COG1033	growth of symbiont in host cell
SLGD_RS00840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SLGD_RS00855	COG1131	(ABC) transporter
SLGD_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS00875	COG1278	Cold shock
SLGD_RS00890	COG2311	Membrane
SLGD_RS00895	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SLGD_RS00905	COG1233	COG1233 Phytoene dehydrogenase and related
SLGD_RS00925	COG2814	Major facilitator Superfamily
SLGD_RS00940	COG1131	(ABC) transporter
SLGD_RS00965	COG2264	protein methyltransferase activity
SLGD_RS00970	COG0747	negative chemotaxis
SLGD_RS00975	COG0601	transmembrane transport
SLGD_RS00985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLGD_RS00990	COG1124	(ABC) transporter
SLGD_RS00995	COG3961	Belongs to the TPP enzyme family
SLGD_RS01010	COG1131	(ABC) transporter
SLGD_RS01020	COG2353	YceI-like domain
SLGD_RS01025	COG1288	antiporter activity
SLGD_RS01035	COG2814	Major facilitator Superfamily
SLGD_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS01065	COG1263	PTS System
SLGD_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS01065	COG2190	(PTS) system
SLGD_RS01070	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS01095	COG1053	succinate dehydrogenase
SLGD_RS01095	COG0431	NADPH-dependent FMN reductase
SLGD_RS01095	COG3976	FMN-binding domain protein
SLGD_RS01110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SLGD_RS01120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLGD_RS01125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SLGD_RS01130	COG0022	dehydrogenase e1 component
SLGD_RS01140	COG1695	Transcriptional regulator
SLGD_RS01165	COG3711	transcriptional antiterminator
SLGD_RS01165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS01170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS01170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLGD_RS01170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLGD_RS01175	COG1482	cell wall glycoprotein biosynthetic process
SLGD_RS01200	COG0706	membrane insertase activity
SLGD_RS01210	COG0531	amino acid
SLGD_RS01265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLGD_RS01285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SLGD_RS01295	COG0363	glucosamine-6-phosphate deaminase activity
SLGD_RS01300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SLGD_RS01315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLGD_RS01320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SLGD_RS01325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SLGD_RS01355	COG1266	CAAX protease self-immunity
SLGD_RS01360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SLGD_RS01380	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SLGD_RS01385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS01385	COG3711	transcriptional antiterminator
SLGD_RS01390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS01400	COG3037	sugar-specific permease SgaT UlaA
SLGD_RS01405	COG1054	Belongs to the UPF0176 family
SLGD_RS01410	COG3386	PFAM SMP-30 Gluconolaconase
SLGD_RS01425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLGD_RS01435	COG1122	ATPase activity
SLGD_RS01445	COG1476	TRANSCRIPTIONal
SLGD_RS01475	COG1705	Flagellar rod assembly protein muramidase FlgJ
SLGD_RS01475	COG3942	CHAP domain
SLGD_RS01520	COG0640	Transcriptional regulator
SLGD_RS01530	COG2226	methyltransferase
SLGD_RS01535	COG2235	arginine
SLGD_RS01545	COG2843	Capsule synthesis protein
SLGD_RS01550	COG4195	phage-related replication protein
SLGD_RS01555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SLGD_RS01590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SLGD_RS01615	COG0297	glycogen (starch) synthase activity
SLGD_RS01625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SLGD_RS01630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SLGD_RS01635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SLGD_RS01640	COG1785	Belongs to the alkaline phosphatase family
SLGD_RS01655	COG2205	protein histidine kinase activity
SLGD_RS01660	COG1136	(ABC) transporter
SLGD_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS01700	COG4932	domain protein
SLGD_RS01700	COG3266	domain, Protein
SLGD_RS01700	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SLGD_RS01700	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SLGD_RS01700	COG3266	domain, Protein
SLGD_RS01700	COG4932	domain protein
SLGD_RS01715	COG0175	sulfate reduction
SLGD_RS01720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SLGD_RS01725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLGD_RS01740	COG0730	response to heat
SLGD_RS01745	COG2046	Belongs to the sulfate adenylyltransferase family
SLGD_RS01750	COG0529	Catalyzes the synthesis of activated sulfate
SLGD_RS01765	COG1328	CTP reductase activity
SLGD_RS01770	COG0602	queuosine metabolic process
SLGD_RS01780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SLGD_RS01785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SLGD_RS01790	COG1510	regulation of RNA biosynthetic process
SLGD_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
SLGD_RS01800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SLGD_RS01805	COG1473	amidohydrolase
SLGD_RS01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SLGD_RS01825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLGD_RS01825	COG0574	Belongs to the PEP-utilizing enzyme family
SLGD_RS01830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SLGD_RS01840	COG2188	Transcriptional regulator
SLGD_RS01845	COG1263	PTS System
SLGD_RS01845	COG2190	(PTS) system
SLGD_RS01845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS01850	COG2723	6-phospho-beta-galactosidase activity
SLGD_RS01860	COG0583	DNA-binding transcription factor activity
SLGD_RS01875	COG3588	fructose-bisphosphate aldolase
SLGD_RS01890	COG1464	Belongs to the NlpA lipoprotein family
SLGD_RS01900	COG0463	Glycosyl transferase, family 2
SLGD_RS01910	COG1215	transferase activity, transferring glycosyl groups
SLGD_RS01910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS01925	COG0583	DNA-binding transcription factor activity
SLGD_RS01930	COG0028	Belongs to the TPP enzyme family
SLGD_RS01935	COG3527	Alpha-acetolactate decarboxylase
SLGD_RS01940	COG1620	l-lactate permease
SLGD_RS01960	COG0167	dihydroorotate dehydrogenase activity
SLGD_RS01965	COG3001	Fructosamine kinase
SLGD_RS01970	COG0596	Alpha beta hydrolase
SLGD_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS02020	COG2814	Major facilitator Superfamily
SLGD_RS02030	COG1113	amino acid transport
SLGD_RS02045	COG3189	MarR family transcriptional regulator
SLGD_RS02065	COG0436	Aminotransferase
SLGD_RS02075	COG2608	mercury ion transmembrane transporter activity
SLGD_RS02080	COG2217	Heavy metal translocating P-type atpase
SLGD_RS02090	COG0110	maltose O-acetyltransferase activity
SLGD_RS02095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS02100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLGD_RS02105	COG1012	belongs to the aldehyde dehydrogenase family
SLGD_RS02115	COG2409	Drug exporters of the RND superfamily
SLGD_RS02125	COG0598	Magnesium transport protein CorA
SLGD_RS02130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SLGD_RS02150	COG1131	(ABC) transporter
SLGD_RS02160	COG3425	synthase
SLGD_RS02175	COG1388	LysM domain
SLGD_RS02175	COG3942	CHAP domain
SLGD_RS02185	COG0583	DNA-binding transcription factor activity
SLGD_RS02190	COG1380	Effector of murein hydrolase LrgA
SLGD_RS02195	COG1346	cytolysis
SLGD_RS02200	COG0028	Belongs to the TPP enzyme family
SLGD_RS02215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLGD_RS02220	COG0039	L-malate dehydrogenase activity
SLGD_RS02225	COG0657	acetylesterase activity
SLGD_RS02235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLGD_RS02255	COG1070	Carbohydrate kinase
SLGD_RS02265	COG1760	l-serine dehydratase
SLGD_RS02270	COG1760	l-serine dehydratase
SLGD_RS02285	COG3764	Sortase (surface protein transpeptidase)
SLGD_RS02295	COG0561	phosphatase activity
SLGD_RS02305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLGD_RS02310	COG0778	Nitroreductase
SLGD_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
SLGD_RS02325	COG2514	catechol 2,3-dioxygenase activity
SLGD_RS02330	COG2388	GCN5-related N-acetyl-transferase
SLGD_RS02350	COG1846	Transcriptional regulator
SLGD_RS02355	COG0346	lactoylglutathione lyase activity
SLGD_RS02360	COG0346	lactoylglutathione lyase activity
SLGD_RS02365	COG0400	carboxylic ester hydrolase activity
SLGD_RS02370	COG3949	Membrane
SLGD_RS02380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SLGD_RS02385	COG0586	Pfam SNARE associated Golgi protein
SLGD_RS02395	COG2022	thiamine diphosphate biosynthetic process
SLGD_RS02415	COG2271	Major facilitator Superfamily
SLGD_RS02430	COG4876	unkown
SLGD_RS02435	COG2357	RelA SpoT domain protein
SLGD_RS02450	COG1802	Transcriptional regulator
SLGD_RS02455	COG1070	Carbohydrate kinase
SLGD_RS02460	COG2610	gluconate transmembrane transporter activity
SLGD_RS02465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SLGD_RS02475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLGD_RS02480	COG0438	transferase activity, transferring glycosyl groups
SLGD_RS02485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLGD_RS02500	COG4221	oxidoreductase activity
SLGD_RS02505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLGD_RS02510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SLGD_RS02515	COG0248	Ppx GppA phosphatase
SLGD_RS02520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SLGD_RS02525	COG1363	Peptidase, m42
SLGD_RS02545	COG3639	organic phosphonate transmembrane transporter activity
SLGD_RS02550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SLGD_RS02565	COG0737	Belongs to the 5'-nucleotidase family
SLGD_RS02570	COG0069	glutamate synthase activity
SLGD_RS02585	COG4619	ABC transporter
SLGD_RS02590	COG0390	transport system, permease component
SLGD_RS02595	COG2205	protein histidine kinase activity
SLGD_RS02600	COG0745	RESPONSE REGULATOR receiver
SLGD_RS02610	COG2814	Major facilitator Superfamily
SLGD_RS02615	COG2272	Belongs to the type-B carboxylesterase lipase family
SLGD_RS02620	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SLGD_RS02645	COG1174	glycine betaine transport
SLGD_RS02685	COG1346	cytolysis
SLGD_RS02690	COG1380	Effector of murein hydrolase LrgA
SLGD_RS02695	COG3279	Response regulator of the LytR AlgR family
SLGD_RS02700	COG3275	phosphorelay sensor kinase activity
SLGD_RS02710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SLGD_RS02725	COG0706	membrane insertase activity
SLGD_RS02735	COG0531	amino acid
SLGD_RS02750	COG1113	amino acid transport
SLGD_RS02770	COG2814	Major facilitator Superfamily
SLGD_RS02780	COG1929	Belongs to the glycerate kinase type-1 family
SLGD_RS02790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SLGD_RS02795	COG0741	lytic transglycosylase activity
SLGD_RS02800	COG0588	phosphoglycerate mutase activity
SLGD_RS02805	COG2814	Major facilitator Superfamily
SLGD_RS02810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLGD_RS02815	COG0765	amino acid transport
SLGD_RS02820	COG1126	abc transporter atp-binding protein
SLGD_RS02860	COG1131	(ABC) transporter
SLGD_RS02870	COG2116	formate transmembrane transporter activity
SLGD_RS02880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLGD_RS02885	COG2146	nitrite reductase [NAD(P)H] activity
SLGD_RS02895	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SLGD_RS02900	COG1140	nitrate reductase beta subunit
SLGD_RS02910	COG2181	nitrate reductase activity
SLGD_RS02920	COG4585	Histidine kinase
SLGD_RS02930	COG2223	nitrite transmembrane transporter activity
SLGD_RS02935	COG1846	Transcriptional regulator
SLGD_RS02970	COG1263	PTS System
SLGD_RS02970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS02995	COG0534	Mate efflux family protein
SLGD_RS03010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLGD_RS03020	COG0601	transmembrane transport
SLGD_RS03030	COG0829	nickel cation binding
SLGD_RS03045	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SLGD_RS03050	COG0804	urea catabolic process
SLGD_RS03060	COG0831	urea catabolic process
SLGD_RS03065	COG4413	Urea transporter
SLGD_RS03075	COG4716	Myosin-crossreactive antigen
SLGD_RS03080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SLGD_RS03090	COG2962	Rard protein
SLGD_RS03105	COG0488	(ABC) transporter
SLGD_RS03130	COG2814	Major facilitator Superfamily
SLGD_RS03135	COG0583	DNA-binding transcription factor activity
SLGD_RS03175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SLGD_RS03195	COG2314	TM2 domain
SLGD_RS03200	COG0492	ferredoxin-NADP+ reductase activity
SLGD_RS03215	COG0604	alcohol dehydrogenase
SLGD_RS03220	COG2822	iron ion transport
SLGD_RS03225	COG2837	iron assimilation
SLGD_RS03230	COG0672	)-iron permease
SLGD_RS03235	COG0805	protein transport
SLGD_RS03240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLGD_RS03245	COG0456	acetyltransferase
SLGD_RS03255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS03260	COG1620	l-lactate permease
SLGD_RS03265	COG0297	glycogen (starch) synthase activity
SLGD_RS03270	COG0579	oxidoreductase
SLGD_RS03320	COG2814	Major facilitator Superfamily
SLGD_RS03330	COG1566	PFAM secretion protein HlyD family protein
SLGD_RS03335	COG2814	Major facilitator Superfamily
SLGD_RS03360	COG0598	Magnesium transport protein CorA
SLGD_RS03365	COG1304	FMN binding
SLGD_RS03370	COG2094	Belongs to the DNA glycosylase MPG family
SLGD_RS03380	COG2017	converts alpha-aldose to the beta-anomer
SLGD_RS03385	COG2258	MOSC domain
SLGD_RS03390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SLGD_RS03395	COG1266	CAAX protease self-immunity
SLGD_RS03400	COG1473	amidohydrolase
SLGD_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS03425	COG1737	Transcriptional regulator
SLGD_RS03430	COG1263	PTS System
SLGD_RS03430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS03440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLGD_RS03455	COG1113	amino acid transport
SLGD_RS03460	COG1737	Transcriptional regulator
SLGD_RS03465	COG1263	PTS System
SLGD_RS03465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS03470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SLGD_RS03480	COG1349	DNA-binding transcription factor activity
SLGD_RS03490	COG1316	TRANSCRIPTIONal
SLGD_RS03520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLGD_RS03525	COG2076	Multidrug Resistance protein
SLGD_RS03530	COG2076	Multidrug Resistance protein
SLGD_RS03535	COG3942	CHAP domain
SLGD_RS03550	COG1757	Na H antiporter
SLGD_RS03555	COG3942	CHAP domain
SLGD_RS03590	COG1960	acyl-CoA dehydrogenase activity
SLGD_RS03595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLGD_RS03605	COG1268	BioY protein
SLGD_RS03615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SLGD_RS03620	COG0725	ABC transporter, periplasmic molybdate-binding protein
SLGD_RS03625	COG4149	molybdate abc transporter
SLGD_RS03630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SLGD_RS03635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SLGD_RS03640	COG0521	Mo-molybdopterin cofactor biosynthetic process
SLGD_RS03670	COG0746	molybdenum cofactor guanylyltransferase activity
SLGD_RS03675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLGD_RS03700	COG2348	transferase activity, transferring amino-acyl groups
SLGD_RS03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLGD_RS03730	COG2252	PERMEase
SLGD_RS03745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SLGD_RS03750	COG0088	Forms part of the polypeptide exit tunnel
SLGD_RS03755	COG0089	rRNA binding
SLGD_RS03760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SLGD_RS03765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SLGD_RS03775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SLGD_RS03780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SLGD_RS03790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SLGD_RS03800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SLGD_RS03815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SLGD_RS03820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SLGD_RS03825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SLGD_RS03830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SLGD_RS03835	COG1841	ribosomal large subunit assembly
SLGD_RS03845	COG0201	protein transport
SLGD_RS03850	COG0563	adenylate kinase activity
SLGD_RS03855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SLGD_RS03860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SLGD_RS03865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLGD_RS03875	COG0202	RNA polymerase activity
SLGD_RS03880	COG0203	ribosomal protein L17
SLGD_RS03890	COG1122	ATPase activity
SLGD_RS03900	COG0101	tRNA pseudouridine synthase activity
SLGD_RS03905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SLGD_RS03910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SLGD_RS03925	COG1131	(ABC) transporter
SLGD_RS03935	COG1131	(ABC) transporter
SLGD_RS03945	COG1309	transcriptional regulator
SLGD_RS03990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SLGD_RS03995	COG1349	DNA-binding transcription factor activity
SLGD_RS04000	COG0698	ribose 5-phosphate isomerase
SLGD_RS04005	COG0698	ribose 5-phosphate isomerase
SLGD_RS04010	COG1105	Belongs to the carbohydrate kinase PfkB family
SLGD_RS04015	COG3684	Belongs to the aldolase LacD family
SLGD_RS04020	COG1447	Phosphotransferase system cellobiose-specific component IIA
SLGD_RS04025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SLGD_RS04025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SLGD_RS04030	COG2723	6-phospho-beta-galactosidase activity
SLGD_RS04040	COG2130	NADP-dependent
SLGD_RS04045	COG0604	alcohol dehydrogenase
SLGD_RS04075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SLGD_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS04090	COG3314	Sporulation integral membrane protein YlbJ
SLGD_RS04100	COG1988	membrane-bound metal-dependent
SLGD_RS04105	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SLGD_RS04110	COG1272	protein, Hemolysin III
SLGD_RS04125	COG2814	Major facilitator Superfamily
SLGD_RS04130	COG0489	protein tyrosine kinase activity
SLGD_RS04200	COG0561	phosphatase activity
SLGD_RS04220	COG0640	Transcriptional regulator
SLGD_RS04225	COG0702	epimerase
SLGD_RS04230	COG1482	cell wall glycoprotein biosynthetic process
SLGD_RS04250	COG0783	Belongs to the Dps family
SLGD_RS04255	COG0813	purine-nucleoside phosphorylase activity
SLGD_RS04260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SLGD_RS04265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SLGD_RS04270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SLGD_RS04305	COG3682	Transcriptional regulator
SLGD_RS04320	COG1854	S-ribosylhomocysteine lyase activity
SLGD_RS04340	COG5146	pantothenate kinase activity
SLGD_RS04350	COG3343	RNA polymerase activity
SLGD_RS04355	COG0504	CTP synthase activity
SLGD_RS04365	COG0191	fructose-bisphosphate aldolase activity
SLGD_RS04370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLGD_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
SLGD_RS04385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SLGD_RS04390	COG0254	rRNA binding
SLGD_RS04400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLGD_RS04405	COG2890	protein-(glutamine-N5) methyltransferase activity
SLGD_RS04410	COG0009	L-threonylcarbamoyladenylate synthase
SLGD_RS04415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLGD_RS04420	COG4475	Protein of unknown function (DUF436)
SLGD_RS04425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLGD_RS04440	COG0356	it plays a direct role in the translocation of protons across the membrane
SLGD_RS04445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLGD_RS04450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SLGD_RS04455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLGD_RS04465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SLGD_RS04470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SLGD_RS04480	COG4836	Membrane
SLGD_RS04485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLGD_RS04490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SLGD_RS04500	COG0629	single-stranded DNA binding
SLGD_RS04510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SLGD_RS04520	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SLGD_RS04525	COG0352	thiamine-phosphate diphosphorylase activity
SLGD_RS04530	COG0706	membrane insertase activity
SLGD_RS04535	COG1418	mRNA catabolic process
SLGD_RS04540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SLGD_RS04545	COG1937	Protein conserved in bacteria
SLGD_RS04555	COG0772	Belongs to the SEDS family
SLGD_RS04560	COG1181	Belongs to the D-alanine--D-alanine ligase family
SLGD_RS04565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SLGD_RS04570	COG0513	Belongs to the DEAD box helicase family
SLGD_RS04580	COG3428	Bacterial PH domain
SLGD_RS04590	COG0736	holo-[acyl-carrier-protein] synthase activity
SLGD_RS04605	COG2337	Toxic component of a toxin-antitoxin (TA) module
SLGD_RS04610	COG2208	phosphoserine phosphatase activity
SLGD_RS04625	COG1191	sigma factor activity
SLGD_RS04630	COG2183	response to ionizing radiation
SLGD_RS04670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SLGD_RS04675	COG0066	3-isopropylmalate dehydratase activity
SLGD_RS04680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SLGD_RS04690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLGD_RS04695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SLGD_RS04705	COG0028	Belongs to the TPP enzyme family
SLGD_RS04715	COG0802	atpase or kinase
SLGD_RS04720	COG1214	PFAM Peptidase M22, glycoprotease
SLGD_RS04725	COG0456	acetyltransferase
SLGD_RS04730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLGD_RS04735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SLGD_RS04740	COG0488	(ABC) transporter
SLGD_RS04745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SLGD_RS04750	COG2391	methyltransferase activity
SLGD_RS04755	COG0425	Belongs to the sulfur carrier protein TusA family
SLGD_RS04760	COG0004	ammonium transporteR
SLGD_RS04765	COG1609	Transcriptional regulator
SLGD_RS04770	COG1621	beta-fructofuranosidase activity
SLGD_RS04775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLGD_RS04795	COG4512	PFAM Accessory gene regulator B
SLGD_RS04800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLGD_RS04825	COG0459	protein refolding
SLGD_RS04840	COG1725	Transcriptional regulator
SLGD_RS04845	COG1129	ABC transporter
SLGD_RS04845	COG0842	Transport permease protein
SLGD_RS04855	COG1131	(ABC) transporter
SLGD_RS04890	COG2706	6-phosphogluconolactonase activity
SLGD_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
SLGD_RS04900	COG1227	inorganic diphosphatase activity
SLGD_RS04905	COG1335	isochorismatase
SLGD_RS04925	COG0077	Prephenate dehydratase
SLGD_RS04935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SLGD_RS04940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SLGD_RS04945	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SLGD_RS04955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SLGD_RS04960	COG4496	protein, YerC YecD
SLGD_RS04965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SLGD_RS04975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLGD_RS04980	COG4851	CamS sex pheromone cAM373 precursor
SLGD_RS04990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SLGD_RS05000	COG0154	amidase activity
SLGD_RS05005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLGD_RS05010	COG1597	lipid kinase activity
SLGD_RS05015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SLGD_RS05040	COG1528	Iron-storage protein
SLGD_RS05060	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLGD_RS05065	COG4129	membrane
SLGD_RS05070	COG0024	Methionine aminopeptidase
SLGD_RS05095	COG1295	ribonuclease BN
SLGD_RS05105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLGD_RS05110	COG4840	Belongs to the UPF0435 family
SLGD_RS05115	COG2309	aminopeptidase activity
SLGD_RS05120	COG1607	acyl-coa hydrolase
SLGD_RS05125	COG0535	radical SAM domain protein
SLGD_RS05130	COG0693	protein deglycase activity
SLGD_RS05135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLGD_RS05140	COG2137	regulation of response to DNA damage stimulus
SLGD_RS05150	COG1134	teichoic acid transport
SLGD_RS05150	COG1388	LysM domain
SLGD_RS05160	COG1988	membrane-bound metal-dependent
SLGD_RS05165	COG1194	a g-specific adenine glycosylase
SLGD_RS05170	COG3557	Belongs to the UPF0374 family
SLGD_RS05180	COG4129	membrane
SLGD_RS05185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SLGD_RS05190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SLGD_RS05200	COG0735	belongs to the Fur family
SLGD_RS05365	COG0765	amino acid transport
SLGD_RS05370	COG1126	abc transporter atp-binding protein
SLGD_RS05375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SLGD_RS05385	COG0363	glucosamine-6-phosphate deaminase activity
SLGD_RS05395	COG0114	fumarate hydratase activity
SLGD_RS05400	COG0564	pseudouridine synthase activity
SLGD_RS05405	COG2203	Gaf domain
SLGD_RS05405	COG4585	Histidine kinase
SLGD_RS05410	COG2197	response regulator
SLGD_RS05425	COG3679	Belongs to the UPF0342 family
SLGD_RS05430	COG0420	3'-5' exonuclease activity
SLGD_RS05455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SLGD_RS05470	COG0537	adenosine 5'-monophosphoramidase activity
SLGD_RS05475	COG1131	(ABC) transporter
SLGD_RS05480	COG4473	ABC transporter
SLGD_RS05485	COG2329	Antibiotic biosynthesis monooxygenase
SLGD_RS05490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SLGD_RS05500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLGD_RS05505	COG3545	Serine hydrolase
SLGD_RS05555	COG0318	PFAM AMP-dependent synthetase and ligase
SLGD_RS05565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SLGD_RS05575	COG1506	peptidase
SLGD_RS05580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SLGD_RS05585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SLGD_RS05595	COG0656	L-ascorbic acid biosynthetic process
SLGD_RS05600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SLGD_RS05615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SLGD_RS05640	COG4193	domain, Protein
SLGD_RS05640	COG5632	N-Acetylmuramoyl-L-alanine amidase
SLGD_RS05640	COG3266	domain, Protein
SLGD_RS05650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SLGD_RS05650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SLGD_RS05660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLGD_RS05660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLGD_RS05665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SLGD_RS05670	COG0506	proline dehydrogenase activity
SLGD_RS05675	COG2267	carboxylic ester hydrolase activity
SLGD_RS05685	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SLGD_RS05690	COG1242	4 iron, 4 sulfur cluster binding
SLGD_RS05695	COG2814	Major facilitator Superfamily
SLGD_RS05700	COG0495	leucyl-tRNA aminoacylation
SLGD_RS05710	COG2081	HI0933 family
SLGD_RS05715	COG2244	polysaccharide biosynthetic process
SLGD_RS05720	COG1187	pseudouridine synthase activity
SLGD_RS05730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLGD_RS05740	COG0510	thiamine kinase activity
SLGD_RS05745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SLGD_RS05755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLGD_RS05760	COG5584	Small secreted protein
SLGD_RS05765	COG1363	Peptidase, m42
SLGD_RS05770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLGD_RS05775	COG4848	Belongs to the UPF0354 family
SLGD_RS05780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLGD_RS05785	COG1674	ftsk spoiiie
SLGD_RS05790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SLGD_RS05795	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SLGD_RS05805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SLGD_RS05805	COG1605	Chorismate mutase
SLGD_RS05810	COG1609	Transcriptional regulator
SLGD_RS05825	COG0123	including yeast histone deacetylase and acetoin utilization protein
SLGD_RS05830	COG0454	-acetyltransferase
SLGD_RS05835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SLGD_RS05840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SLGD_RS05850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SLGD_RS05860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLGD_RS05865	COG0204	Acyl-transferase
SLGD_RS05870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS05870	COG1263	PTS System
SLGD_RS05880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLGD_RS05885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SLGD_RS05890	COG1764	response to oxidative stress
SLGD_RS05895	COG0584	glycerophosphoryl diester phosphodiesterase
SLGD_RS05900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SLGD_RS05905	COG1956	GAF domain-containing protein
SLGD_RS05910	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SLGD_RS05915	COG1104	cysteine desulfurase activity
SLGD_RS05920	COG0301	tRNA thio-modification
SLGD_RS05925	COG0730	response to heat
SLGD_RS05930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SLGD_RS05935	COG0827	DNA restriction-modification system
SLGD_RS05940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SLGD_RS05945	COG0589	response to stress
SLGD_RS05950	COG0686	Belongs to the AlaDH PNT family
SLGD_RS05955	COG0006	proline dipeptidase activity
SLGD_RS05960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SLGD_RS05970	COG4109	DRTGG domain
SLGD_RS05975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLGD_RS05980	COG0587	DNA-directed DNA polymerase activity
SLGD_RS05985	COG0281	malic enzyme
SLGD_RS05990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SLGD_RS05995	COG0825	malonyl-CoA metabolic process
SLGD_RS06000	COG0205	6-phosphofructokinase activity
SLGD_RS06005	COG0469	pyruvate kinase activity
SLGD_RS06010	COG1113	amino acid transport
SLGD_RS06015	COG0372	Belongs to the citrate synthase family
SLGD_RS06020	COG0538	isocitrate dehydrogenase activity
SLGD_RS06025	COG0745	RESPONSE REGULATOR receiver
SLGD_RS06030	COG5002	protein histidine kinase activity
SLGD_RS06035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLGD_RS06035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLGD_RS06040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLGD_RS06045	COG0237	dephospho-CoA kinase activity
SLGD_RS06050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SLGD_RS06055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SLGD_RS06060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SLGD_RS06065	COG3611	Membrane attachment protein
SLGD_RS06070	COG1484	DNA-dependent DNA replication
SLGD_RS06080	COG0833	amino acid
SLGD_RS06085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SLGD_RS06090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SLGD_RS06095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SLGD_RS06100	COG4112	unkown
SLGD_RS06110	COG0544	peptidyl-prolyl cis-trans isomerase activity
SLGD_RS06115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SLGD_RS06135	COG0181	hydroxymethylbilane synthase activity
SLGD_RS06150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SLGD_RS06160	COG2818	Glycosylase
SLGD_RS06165	COG0525	valine-tRNA ligase activity
SLGD_RS06170	COG0285	dihydrofolate synthase activity
SLGD_RS06180	COG2003	Belongs to the UPF0758 family
SLGD_RS06190	COG1792	Involved in formation and maintenance of cell shape
SLGD_RS06200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SLGD_RS06205	COG2868	ribosomal protein
SLGD_RS06215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SLGD_RS06220	COG4492	Belongs to the UPF0735 family
SLGD_RS06225	COG0632	four-way junction helicase activity
SLGD_RS06230	COG2255	four-way junction helicase activity
SLGD_RS06235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SLGD_RS06240	COG0343	queuine tRNA-ribosyltransferase activity
SLGD_RS06245	COG1862	Preprotein translocase
SLGD_RS06250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLGD_RS06250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLGD_RS06255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SLGD_RS06255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SLGD_RS06265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SLGD_RS06270	COG1490	D-aminoacyl-tRNA deacylase activity
SLGD_RS06275	COG0860	N-Acetylmuramoyl-L-alanine amidase
SLGD_RS06280	COG0124	histidyl-tRNA synthetase
SLGD_RS06285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SLGD_RS06290	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SLGD_RS06295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SLGD_RS06300	COG1959	2 iron, 2 sulfur cluster binding
SLGD_RS06305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLGD_RS06310	COG1104	cysteine desulfurase activity
SLGD_RS06315	COG0482	sulfurtransferase activity
SLGD_RS06325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SLGD_RS06330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SLGD_RS06335	COG4472	Bacterial protein of unknown function (DUF965)
SLGD_RS06340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SLGD_RS06350	COG4122	O-methyltransferase activity
SLGD_RS06355	COG0826	peptidase U32
SLGD_RS06360	COG0826	peptidase U32
SLGD_RS06365	COG0572	uridine kinase
SLGD_RS06370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLGD_RS06375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SLGD_RS06380	COG1984	allophanate hydrolase subunit 2
SLGD_RS06385	COG0511	ligase activity, forming carbon-carbon bonds
SLGD_RS06390	COG0439	Biotin carboxylase
SLGD_RS06400	COG1914	H( )-stimulated, divalent metal cation uptake system
SLGD_RS06405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SLGD_RS06410	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SLGD_RS06415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SLGD_RS06425	COG1534	Rna-binding protein
SLGD_RS06430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SLGD_RS06435	COG1713	HD superfamily hydrolase involved in NAD metabolism
SLGD_RS06440	COG0799	negative regulation of ribosome biogenesis
SLGD_RS06445	COG2226	methyltransferase
SLGD_RS06450	COG1596	polysaccharide export
SLGD_RS06450	COG1555	photosystem II stabilization
SLGD_RS06455	COG2131	deaminase
SLGD_RS06460	COG2333	competence protein COMEC
SLGD_RS06460	COG0658	competence protein
SLGD_RS06465	COG1466	dna polymerase III delta subunit
SLGD_RS06470	COG0268	Binds directly to 16S ribosomal RNA
SLGD_RS06475	COG0481	GTPase activity
SLGD_RS06480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SLGD_RS06490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLGD_RS06495	COG0443	Heat shock 70 kDa protein
SLGD_RS06500	COG0484	heat shock protein binding
SLGD_RS06505	COG2264	protein methyltransferase activity
SLGD_RS06510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SLGD_RS06515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLGD_RS06525	COG1030	water channel activity
SLGD_RS06530	COG4864	UPF0365 protein
SLGD_RS06540	COG1702	phosphate starvation-inducible protein PhoH
SLGD_RS06545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SLGD_RS06550	COG0295	cytidine deaminase activity
SLGD_RS06555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SLGD_RS06560	COG1381	Involved in DNA repair and RecF pathway recombination
SLGD_RS06565	COG0423	glycine-tRNA ligase activity
SLGD_RS06570	COG0517	IMP dehydrogenase activity
SLGD_RS06575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SLGD_RS06590	COG2384	SAM-dependent methyltransferase
SLGD_RS06600	COG0513	Belongs to the DEAD box helicase family
SLGD_RS06605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SLGD_RS06610	COG1121	(ABC) transporter
SLGD_RS06615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLGD_RS06625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SLGD_RS06630	COG0768	penicillin binding
SLGD_RS06635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SLGD_RS06640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SLGD_RS06645	COG0705	Rhomboid family
SLGD_RS06645	COG0457	Tetratricopeptide repeat
SLGD_RS06650	COG4483	Protein conserved in bacteria
SLGD_RS06655	COG1940	carbohydrate kinase activity
SLGD_RS06660	COG0011	TIGRFAM Protein of
SLGD_RS06665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLGD_RS06670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SLGD_RS06675	COG1459	type II secretion system
SLGD_RS06680	COG4537	Required for transformation and DNA binding
SLGD_RS06705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SLGD_RS06710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SLGD_RS06715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SLGD_RS06720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SLGD_RS06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SLGD_RS06730	COG0095	Lipoate-protein ligase
SLGD_RS06745	COG0006	proline dipeptidase activity
SLGD_RS06750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SLGD_RS06755	COG0511	ligase activity, forming carbon-carbon bonds
SLGD_RS06760	COG0439	Biotin carboxylase
SLGD_RS06765	COG1302	Protein conserved in bacteria
SLGD_RS06770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLGD_RS06790	COG1438	arginine binding
SLGD_RS06795	COG0497	DNA recombination
SLGD_RS06800	COG0280	phosphate acetyltransferase
SLGD_RS06805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLGD_RS06810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SLGD_RS06815	COG0022	dehydrogenase e1 component
SLGD_RS06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLGD_RS06830	COG4129	membrane
SLGD_RS06835	COG2195	Cleaves the N-terminal amino acid of tripeptides
SLGD_RS06845	COG1609	Transcriptional regulator
SLGD_RS06850	COG0366	Alpha amylase catalytic
SLGD_RS06860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SLGD_RS06870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SLGD_RS06875	COG0300	oxidoreductase activity
SLGD_RS06880	COG0667	Aldo Keto reductase
SLGD_RS06885	COG0494	nUDIX hydrolase
SLGD_RS06890	COG0735	belongs to the Fur family
SLGD_RS06895	COG4974	Belongs to the 'phage' integrase family
SLGD_RS06905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SLGD_RS06910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SLGD_RS06915	COG1187	pseudouridine synthase activity
SLGD_RS06920	COG0745	RESPONSE REGULATOR receiver
SLGD_RS06935	COG1141	Ferredoxin
SLGD_RS06945	COG0514	ATP-dependent DNA helicase (RecQ)
SLGD_RS06950	COG1388	LysM domain
SLGD_RS06955	COG0492	ferredoxin-NADP+ reductase activity
SLGD_RS06975	COG0539	negative regulation of cytoplasmic translation
SLGD_RS06985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SLGD_RS07000	COG2226	methyltransferase
SLGD_RS07005	COG0142	geranyltranstransferase activity
SLGD_RS07015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SLGD_RS07020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SLGD_RS07045	COG2738	Putative neutral zinc metallopeptidase
SLGD_RS07050	COG1694	Mazg nucleotide pyrophosphohydrolase
SLGD_RS07055	COG0438	transferase activity, transferring glycosyl groups
SLGD_RS07060	COG0617	tRNA 3'-terminal CCA addition
SLGD_RS07065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SLGD_RS07065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SLGD_RS07070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SLGD_RS07070	COG1199	ATP-dependent helicase activity
SLGD_RS07075	COG0017	Asparaginyl-tRNA synthetase
SLGD_RS07080	COG3935	DnaD domain protein
SLGD_RS07085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SLGD_RS07095	COG4499	WXG100 protein secretion system (Wss), protein YukC
SLGD_RS07095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLGD_RS07110	COG4474	Belongs to the UPF0398 family
SLGD_RS07115	COG3599	regulation of cell shape
SLGD_RS07120	COG0116	Belongs to the methyltransferase superfamily
SLGD_RS07130	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SLGD_RS07135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLGD_RS07140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SLGD_RS07145	COG0512	Glutamine amidotransferase of anthranilate synthase
SLGD_RS07150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SLGD_RS07155	COG0134	indole-3-glycerol-phosphate synthase activity
SLGD_RS07160	COG0135	phosphoribosylanthranilate isomerase activity
SLGD_RS07175	COG2348	transferase activity, transferring amino-acyl groups
SLGD_RS07180	COG2348	transferase activity, transferring amino-acyl groups
SLGD_RS07185	COG0561	phosphatase activity
SLGD_RS07200	COG1164	Oligoendopeptidase f
SLGD_RS07210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SLGD_RS07215	COG0581	inorganic phosphate transmembrane transporter activity
SLGD_RS07220	COG0573	inorganic phosphate transmembrane transporter activity
SLGD_RS07225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SLGD_RS07230	COG2996	Protein conserved in bacteria
SLGD_RS07235	COG0488	(ABC) transporter
SLGD_RS07240	COG0527	aspartate kinase activity
SLGD_RS07245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SLGD_RS07250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLGD_RS07255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SLGD_RS07260	COG2171	N-acyltransferase activity
SLGD_RS07265	COG1473	amidohydrolase
SLGD_RS07285	COG1278	Cold shock
SLGD_RS07295	COG1254	Belongs to the acylphosphatase family
SLGD_RS07305	COG3853	Toxic anion resistance protein (TelA)
SLGD_RS07310	COG1114	Component of the transport system for branched-chain amino acids
SLGD_RS07315	COG4548	von Willebrand factor, type A
SLGD_RS07320	COG0714	Associated with various cellular activities
SLGD_RS07340	COG0567	Dehydrogenase, E1 component
SLGD_RS07345	COG5002	protein histidine kinase activity
SLGD_RS07350	COG0745	RESPONSE REGULATOR receiver
SLGD_RS07355	COG0671	phosphoesterase, PA-phosphatase related
SLGD_RS07360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLGD_RS07370	COG0793	Belongs to the peptidase S41A family
SLGD_RS07375	COG4479	Belongs to the UPF0346 family
SLGD_RS07385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLGD_RS07415	COG1413	lyase activity
SLGD_RS07420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SLGD_RS07425	COG0328	RNA-DNA hybrid ribonuclease activity
SLGD_RS07430	COG1363	Peptidase, m42
SLGD_RS07450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS07460	COG3623	hexulose-6-phosphate isomerase
SLGD_RS07480	COG0287	Prephenate dehydrogenase
SLGD_RS07485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SLGD_RS07490	COG1942	4-Oxalocrotonate Tautomerase
SLGD_RS07520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SLGD_RS07520	COG0392	lysyltransferase activity
SLGD_RS07525	COG0628	permease
SLGD_RS07530	COG1115	amino acid carrier protein
SLGD_RS07535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLGD_RS07540	COG0187	DNA topoisomerase II activity
SLGD_RS07545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SLGD_RS07550	COG4841	protein insertion into membrane
SLGD_RS07560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SLGD_RS07565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SLGD_RS07570	COG1970	mechanosensitive ion channel activity
SLGD_RS07585	COG4846	Membrane protein involved in cytochrome C biogenesis
SLGD_RS07590	COG3763	UPF0154 protein
SLGD_RS07595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SLGD_RS07600	COG4224	UPF0291 protein
SLGD_RS07610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SLGD_RS07615	COG2340	Cysteine-rich secretory protein family
SLGD_RS07625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLGD_RS07640	COG0833	amino acid
SLGD_RS07650	COG0561	phosphatase activity
SLGD_RS07655	COG0083	homoserine kinase activity
SLGD_RS07660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SLGD_RS07665	COG0460	homoserine dehydrogenase
SLGD_RS07670	COG0527	aspartate kinase activity
SLGD_RS07685	COG1525	nuclease
SLGD_RS07700	COG2197	response regulator
SLGD_RS07705	COG4585	Histidine kinase
SLGD_RS07705	COG2203	Gaf domain
SLGD_RS07715	COG1131	(ABC) transporter
SLGD_RS07720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SLGD_RS07735	COG0789	Transcriptional regulator
SLGD_RS07740	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SLGD_RS07745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SLGD_RS07755	COG1923	regulation of RNA biosynthetic process
SLGD_RS07760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SLGD_RS07770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SLGD_RS07775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SLGD_RS07780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SLGD_RS07790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SLGD_RS07795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SLGD_RS07810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLGD_RS07820	COG4195	phage-related replication protein
SLGD_RS07825	COG1013	pyruvate-flavodoxin oxidoreductase activity
SLGD_RS07830	COG0674	pyruvate-flavodoxin oxidoreductase activity
SLGD_RS07830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SLGD_RS07835	COG1692	metallophosphoesterase
SLGD_RS07845	COG1418	mRNA catabolic process
SLGD_RS07850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SLGD_RS07855	COG1546	Belongs to the CinA family
SLGD_RS07855	COG1058	Belongs to the CinA family
SLGD_RS07875	COG0300	oxidoreductase activity
SLGD_RS07880	COG0612	Peptidase, M16
SLGD_RS07885	COG0612	Peptidase, M16
SLGD_RS07890	COG2188	Transcriptional regulator
SLGD_RS07895	COG1674	ftsk spoiiie
SLGD_RS07900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLGD_RS07905	COG1185	polyribonucleotide nucleotidyltransferase activity
SLGD_RS07915	COG0196	riboflavin kinase activity
SLGD_RS07925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SLGD_RS07930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SLGD_RS07935	COG1358	cellular component organization or biogenesis
SLGD_RS07940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SLGD_RS07945	COG0195	Participates in both transcription termination and antitermination
SLGD_RS07950	COG0779	Required for maturation of 30S ribosomal subunits
SLGD_RS07955	COG2176	DNA-directed DNA polymerase activity
SLGD_RS07960	COG0442	prolyl-tRNA aminoacylation
SLGD_RS07975	COG4589	Belongs to the CDS family
SLGD_RS07980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SLGD_RS07985	COG0233	cytoplasmic translational termination
SLGD_RS07990	COG0528	UMP kinase activity
SLGD_RS07995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SLGD_RS08000	COG0052	Belongs to the universal ribosomal protein uS2 family
SLGD_RS08005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SLGD_RS08010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SLGD_RS08015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SLGD_RS08020	COG4974	Belongs to the 'phage' integrase family
SLGD_RS08025	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SLGD_RS08030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SLGD_RS08035	COG0758	DNA mediated transformation
SLGD_RS08050	COG2348	transferase activity, transferring amino-acyl groups
SLGD_RS08065	COG0045	succinate-CoA ligase (ADP-forming) activity
SLGD_RS08070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLGD_RS08080	COG4485	Bacterial membrane protein, YfhO
SLGD_RS08090	COG0335	large ribosomal subunit rRNA binding
SLGD_RS08095	COG0336	Belongs to the RNA methyltransferase TrmD family
SLGD_RS08100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SLGD_RS08105	COG0228	four-way junction DNA binding
SLGD_RS08120	COG3682	Transcriptional regulator
SLGD_RS08150	COG0183	Belongs to the thiolase family
SLGD_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
SLGD_RS08160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SLGD_RS08165	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SLGD_RS08170	COG0552	protein localization to endoplasmic reticulum
SLGD_RS08175	COG1196	nuclear chromosome segregation
SLGD_RS08180	COG0571	ribonuclease III activity
SLGD_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLGD_RS08200	COG0416	fatty acid biosynthetic process
SLGD_RS08205	COG1349	DNA-binding transcription factor activity
SLGD_RS08210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SLGD_RS08215	COG1461	Dihydroxyacetone kinase
SLGD_RS08220	COG1302	Protein conserved in bacteria
SLGD_RS08225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLGD_RS08235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SLGD_RS08250	COG0631	protein serine/threonine phosphatase activity
SLGD_RS08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SLGD_RS08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLGD_RS08265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SLGD_RS08275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SLGD_RS08280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SLGD_RS08285	COG1758	RNA polymerase activity
SLGD_RS08290	COG0194	GDP metabolic process
SLGD_RS08310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SLGD_RS08315	COG0284	orotidine-5'-phosphate decarboxylase activity
SLGD_RS08325	COG0505	Belongs to the CarA family
SLGD_RS08335	COG0540	Belongs to the ATCase OTCase family
SLGD_RS08340	COG2233	PERMEase
SLGD_RS08345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SLGD_RS08350	COG0564	pseudouridine synthase activity
SLGD_RS08355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SLGD_RS08365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SLGD_RS08370	COG3599	regulation of cell shape
SLGD_RS08375	COG2302	S4 RNA-binding domain
SLGD_RS08380	COG0762	integral membrane protein
SLGD_RS08385	COG1799	cell septum assembly
SLGD_RS08390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SLGD_RS08395	COG1496	oxidoreductase activity
SLGD_RS08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SLGD_RS08405	COG0849	cell division
SLGD_RS08410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SLGD_RS08415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLGD_RS08420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLGD_RS08425	COG0768	penicillin binding
SLGD_RS08430	COG4839	cell division protein FtsL
SLGD_RS08435	COG0275	rRNA processing
SLGD_RS08445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SLGD_RS08450	COG0454	-acetyltransferase
SLGD_RS08460	COG1011	Hydrolase
SLGD_RS08470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SLGD_RS08475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SLGD_RS08480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SLGD_RS08485	COG1053	succinate dehydrogenase
SLGD_RS08490	COG2009	succinate dehydrogenase
SLGD_RS08495	COG0322	excinuclease ABC activity
SLGD_RS08500	COG3118	belongs to the thioredoxin family
SLGD_RS08505	COG1193	negative regulation of DNA recombination
SLGD_RS08510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SLGD_RS08510	COG1796	DNA polymerase
SLGD_RS08520	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SLGD_RS08525	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLGD_RS08530	COG0072	phenylalanine-tRNA ligase activity
SLGD_RS08530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLGD_RS08535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SLGD_RS08540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLGD_RS08545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SLGD_RS08555	COG1323	Belongs to the UPF0348 family
SLGD_RS08560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SLGD_RS08565	COG0742	ribosomal rna small subunit methyltransferase
SLGD_RS08585	COG3679	Belongs to the UPF0342 family
SLGD_RS08600	COG0109	protoheme IX farnesyltransferase activity
SLGD_RS08605	COG1612	heme a metabolic process
SLGD_RS08620	COG0772	Belongs to the SEDS family
SLGD_RS08625	COG4838	Belongs to the UPF0358 family
SLGD_RS08630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLGD_RS08640	COG1217	gtp-binding protein TYPA
SLGD_RS08650	COG0483	inositol monophosphate 1-phosphatase activity
SLGD_RS08655	COG4493	Belongs to the UPF0637 family
SLGD_RS08675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SLGD_RS08680	COG1177	transmembrane transport
SLGD_RS08700	COG4476	Belongs to the UPF0223 family
SLGD_RS08715	COG0022	dehydrogenase e1 component
SLGD_RS08730	COG0242	peptide deformylase activity
SLGD_RS08735	COG5503	Protein of unknown function (DUF1447)
SLGD_RS08740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLGD_RS08755	COG0569	domain protein
SLGD_RS08770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLGD_RS08785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SLGD_RS08800	COG4172	Belongs to the ABC transporter superfamily
SLGD_RS08805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SLGD_RS08810	COG0151	Belongs to the GarS family
SLGD_RS08815	COG0138	bifunctional purine biosynthesis protein purh
SLGD_RS08825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SLGD_RS08835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLGD_RS08840	COG0047	phosphoribosylformylglycinamidine synthase activity
SLGD_RS08845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLGD_RS08850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SLGD_RS08855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SLGD_RS08860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SLGD_RS08865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLGD_RS08875	COG1017	nitric oxide dioxygenase activity
SLGD_RS08875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLGD_RS08885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SLGD_RS08895	COG1845	cytochrome c oxidase, subunit III
SLGD_RS08900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SLGD_RS08910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLGD_RS08915	COG1316	TRANSCRIPTIONal
SLGD_RS08940	COG3594	Acyltransferase
SLGD_RS08945	COG0436	Aminotransferase
SLGD_RS08950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SLGD_RS08955	COG0596	Alpha beta hydrolase
SLGD_RS08960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SLGD_RS08965	COG1169	isochorismate synthase
SLGD_RS08970	COG1575	Belongs to the MenA family. Type 1 subfamily
SLGD_RS09030	COG4873	Protein conserved in bacteria
SLGD_RS09040	COG0737	Belongs to the 5'-nucleotidase family
SLGD_RS09045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SLGD_RS09050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLGD_RS09050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLGD_RS09055	COG0861	Integral membrane protein TerC family
SLGD_RS09070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SLGD_RS09075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLGD_RS09080	COG2814	Major facilitator Superfamily
SLGD_RS09085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SLGD_RS09090	COG0789	Transcriptional regulator
SLGD_RS09095	COG4221	oxidoreductase activity
SLGD_RS09105	COG0628	permease
SLGD_RS09115	COG0569	domain protein
SLGD_RS09115	COG0475	glutathione-regulated potassium exporter activity
SLGD_RS09120	COG2239	Acts as a magnesium transporter
SLGD_RS09125	COG0564	pseudouridine synthase activity
SLGD_RS09135	COG2357	RelA SpoT domain protein
SLGD_RS09150	COG2346	COG2346, Truncated hemoglobins
SLGD_RS09155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SLGD_RS09160	COG1164	Oligoendopeptidase f
SLGD_RS09175	COG1393	Belongs to the ArsC family
SLGD_RS09180	COG0180	Tryptophanyl-tRNA synthetase
SLGD_RS09185	COG2226	methyltransferase
SLGD_RS09190	COG4166	transmembrane transport
SLGD_RS09195	COG4608	Belongs to the ABC transporter superfamily
SLGD_RS09200	COG0444	Belongs to the ABC transporter superfamily
SLGD_RS09205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLGD_RS09210	COG0601	transmembrane transport
SLGD_RS09225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLGD_RS09235	COG0542	response to heat
SLGD_RS09245	COG0561	phosphatase activity
SLGD_RS09250	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLGD_RS09265	COG1074	ATP-dependent DNA helicase activity
SLGD_RS09285	COG0398	Pfam SNARE associated Golgi protein
SLGD_RS09290	COG0166	Belongs to the GPI family
SLGD_RS09295	COG0137	argininosuccinate synthase activity
SLGD_RS09325	COG1902	pentaerythritol trinitrate reductase activity
SLGD_RS09330	COG1098	S1 RNA binding domain
SLGD_RS09335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SLGD_RS09345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLGD_RS09345	COG2111	Na H antiporter
SLGD_RS09350	COG2111	Na H antiporter
SLGD_RS09355	COG1006	Multisubunit Na H antiporter MnhC subunit
SLGD_RS09360	COG0651	ATP synthesis coupled electron transport
SLGD_RS09365	COG1863	multisubunit Na H antiporter MnhE subunit
SLGD_RS09370	COG2212	antiporter activity
SLGD_RS09375	COG1320	monovalent cation:proton antiporter activity
SLGD_RS09385	COG2050	protein possibly involved in aromatic compounds catabolism
SLGD_RS09390	COG2056	Na+-H+ antiporter family
SLGD_RS09395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLGD_RS09400	COG1252	NADH dehydrogenase
SLGD_RS09410	COG1132	(ABC) transporter
SLGD_RS09420	COG1129	ABC transporter
SLGD_RS09450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLGD_RS09450	COG2226	methyltransferase
SLGD_RS09450	COG3433	isochorismatase activity
SLGD_RS09455	COG1021	2,3-dihydroxybenzoate-AMP ligase
SLGD_RS09470	COG0316	Belongs to the HesB IscA family
SLGD_RS09475	COG4844	belongs to the
SLGD_RS09480	COG1252	NADH dehydrogenase
SLGD_RS09485	COG4837	Protein of unknown function (DUF1462)
SLGD_RS09490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SLGD_RS09495	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SLGD_RS09500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLGD_RS09505	COG1696	Membrane protein involved in D-alanine export
SLGD_RS09510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLGD_RS09520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLGD_RS09525	COG0647	UMP catabolic process
SLGD_RS09530	COG2445	Protein of unknown function DUF86
SLGD_RS09540	COG4470	Protein conserved in bacteria
SLGD_RS09545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SLGD_RS09550	COG0737	Belongs to the 5'-nucleotidase family
SLGD_RS09555	COG0730	response to heat
SLGD_RS09560	COG1801	Protein of unknown function DUF72
SLGD_RS09565	COG2070	2-Nitropropane dioxygenase
SLGD_RS09570	COG1253	flavin adenine dinucleotide binding
SLGD_RS09685	COG3942	CHAP domain
SLGD_RS09685	COG1388	LysM domain
SLGD_RS09705	COG0719	Fe-S assembly protein
SLGD_RS09710	COG0822	iron-sulfur transferase activity
SLGD_RS09720	COG0719	Fe-S assembly protein
SLGD_RS09725	COG0396	ATPase activity
SLGD_RS09775	COG5484	DNA packaging
SLGD_RS09775	COG3728	DNA packaging
SLGD_RS09855	COG0582	viral genome integration into host DNA
SLGD_RS09860	COG1464	Belongs to the NlpA lipoprotein family
SLGD_RS09865	COG2011	ABC-type metal ion transport system permease component
SLGD_RS09870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLGD_RS09880	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SLGD_RS09885	COG0509	glycine decarboxylation via glycine cleavage system
SLGD_RS09890	COG1393	Belongs to the ArsC family
SLGD_RS09895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLGD_RS09905	COG0710	3-dehydroquinate dehydratase activity
SLGD_RS09910	COG1764	response to oxidative stress
SLGD_RS09920	COG0588	phosphoglycerate mutase activity
SLGD_RS09950	COG4195	phage-related replication protein
SLGD_RS09965	COG2259	Doxx family
SLGD_RS09970	COG0346	lactoylglutathione lyase activity
SLGD_RS09980	COG1611	Belongs to the LOG family
SLGD_RS10035	COG0557	exoribonuclease II activity
SLGD_RS10040	COG1647	Serine aminopeptidase, S33
SLGD_RS10045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SLGD_RS10055	COG0148	phosphopyruvate hydratase activity
SLGD_RS10060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SLGD_RS10065	COG0149	triose-phosphate isomerase activity
SLGD_RS10070	COG0126	phosphoglycerate kinase activity
SLGD_RS10090	COG1090	epimerase
SLGD_RS10095	COG0740	serine-type endopeptidase activity
SLGD_RS10105	COG1481	regulation of sporulation
SLGD_RS10110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SLGD_RS10115	COG1660	Displays ATPase and GTPase activities
SLGD_RS10120	COG0492	ferredoxin-NADP+ reductase activity
SLGD_RS10135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SLGD_RS10140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SLGD_RS10145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SLGD_RS10165	COG3942	CHAP domain
SLGD_RS10165	COG1388	LysM domain
SLGD_RS10170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SLGD_RS10175	COG0653	protein targeting
SLGD_RS10185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SLGD_RS10190	COG1040	competence protein
SLGD_RS10195	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SLGD_RS10205	COG1739	Uncharacterized protein family UPF0029
SLGD_RS10210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLGD_RS10215	COG2199	diguanylate cyclase activity
SLGD_RS10230	COG2195	Cleaves the N-terminal amino acid of tripeptides
SLGD_RS10235	COG1929	Belongs to the glycerate kinase type-1 family
SLGD_RS10255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SLGD_RS10265	COG4607	ABC-type enterochelin transport system periplasmic component
SLGD_RS10270	COG4604	ABC transporter, ATP-binding protein
SLGD_RS10275	COG4605	iron ion homeostasis
SLGD_RS10280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS10285	COG4607	ABC-type enterochelin transport system periplasmic component
SLGD_RS10290	COG4604	ABC transporter, ATP-binding protein
SLGD_RS10295	COG4605	iron ion homeostasis
SLGD_RS10300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS10305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLGD_RS10310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLGD_RS10315	COG1780	Probably involved in ribonucleotide reductase function
SLGD_RS10325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SLGD_RS10330	COG3104	oligopeptide transport
SLGD_RS10335	COG1597	lipid kinase activity
SLGD_RS10350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLGD_RS10355	COG3104	oligopeptide transport
SLGD_RS10360	COG1174	glycine betaine transport
SLGD_RS10370	COG0514	ATP-dependent DNA helicase (RecQ)
SLGD_RS10375	COG0488	(ABC) transporter
SLGD_RS10385	COG1368	sulfuric ester hydrolase activity
SLGD_RS10395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SLGD_RS10405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SLGD_RS10405	COG0512	Glutamine amidotransferase of anthranilate synthase
SLGD_RS10410	COG0512	Glutamine amidotransferase of anthranilate synthase
SLGD_RS10410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SLGD_RS10420	COG0720	synthase
SLGD_RS10435	COG0463	Glycosyl transferase, family 2
SLGD_RS10440	COG0656	L-ascorbic acid biosynthetic process
SLGD_RS10445	COG1253	flavin adenine dinucleotide binding
SLGD_RS10450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLGD_RS10450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLGD_RS10450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLGD_RS10455	COG1105	Belongs to the carbohydrate kinase PfkB family
SLGD_RS10460	COG1349	DNA-binding transcription factor activity
SLGD_RS10465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SLGD_RS10490	COG0471	metal ion transport
SLGD_RS10495	COG0039	L-malate dehydrogenase activity
SLGD_RS10505	COG0523	cobalamin synthesis protein
SLGD_RS10515	COG1968	undecaprenyl-diphosphatase activity
SLGD_RS10525	COG1671	Belongs to the UPF0178 family
SLGD_RS10530	COG1611	Belongs to the LOG family
SLGD_RS10555	COG2839	Protein conserved in bacteria
SLGD_RS10560	COG2814	Major facilitator Superfamily
SLGD_RS10565	COG0583	DNA-binding transcription factor activity
SLGD_RS10580	COG0217	transcriptional regulatory protein
SLGD_RS10600	COG1388	LysM domain
SLGD_RS10600	COG3942	CHAP domain
SLGD_RS10605	COG0306	phosphate transporter
SLGD_RS10610	COG1392	Phosphate transport regulator
SLGD_RS10615	COG0577	efflux transmembrane transporter activity
SLGD_RS10620	COG1136	(ABC) transporter
SLGD_RS10625	COG2205	protein histidine kinase activity
SLGD_RS10630	COG0745	RESPONSE REGULATOR receiver
SLGD_RS10635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLGD_RS10645	COG0657	acetylesterase activity
SLGD_RS10650	COG3949	Membrane
SLGD_RS10660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SLGD_RS10665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS10670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS10675	COG1120	ATPase activity
SLGD_RS10680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SLGD_RS10690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SLGD_RS10695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS10695	COG0463	Glycosyl transferase, family 2
SLGD_RS10700	COG0438	transferase activity, transferring glycosyl groups
SLGD_RS10705	COG1132	(ABC) transporter
SLGD_RS10710	COG1686	Belongs to the peptidase S11 family
SLGD_RS10715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SLGD_RS10720	COG1215	transferase activity, transferring glycosyl groups
SLGD_RS10725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS10730	COG1682	transport, permease protein
SLGD_RS10735	COG1134	teichoic acid transport
SLGD_RS10750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SLGD_RS10760	COG1321	iron dependent repressor
SLGD_RS10765	COG1121	(ABC) transporter
SLGD_RS10770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLGD_RS10775	COG0803	Belongs to the bacterial solute-binding protein 9 family
SLGD_RS10785	COG1320	monovalent cation:proton antiporter activity
SLGD_RS10790	COG2212	antiporter activity
SLGD_RS10795	COG1863	multisubunit Na H antiporter MnhE subunit
SLGD_RS10800	COG0651	ATP synthesis coupled electron transport
SLGD_RS10805	COG1006	Multisubunit Na H antiporter MnhC subunit
SLGD_RS10810	COG2111	Na H antiporter
SLGD_RS10815	COG2111	Na H antiporter
SLGD_RS10815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLGD_RS10820	COG4974	Belongs to the 'phage' integrase family
SLGD_RS10850	COG0596	Alpha beta hydrolase
SLGD_RS10875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLGD_RS10880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLGD_RS10900	COG0018	arginyl-trna synthetase
SLGD_RS10920	COG1064	alcohol dehydrogenase
SLGD_RS10930	COG1078	dGTPase activity
SLGD_RS10940	COG0655	NAD(P)H dehydrogenase (quinone) activity
SLGD_RS10945	COG0667	Aldo Keto reductase
SLGD_RS10965	COG5632	N-Acetylmuramoyl-L-alanine amidase
SLGD_RS10965	COG1388	LysM domain
SLGD_RS11075	COG1783	phage Terminase large subunit
SLGD_RS11130	COG0305	Participates in initiation and elongation during chromosome replication
SLGD_RS11210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SLGD_RS11215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLGD_RS11220	COG4844	belongs to the
SLGD_RS11240	COG0095	Lipoate-protein ligase
SLGD_RS11250	COG3253	May function as heme-dependent peroxidase
SLGD_RS11280	COG2363	Small membrane protein
SLGD_RS11290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLGD_RS11325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SLGD_RS11330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SLGD_RS11340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SLGD_RS11350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLGD_RS11380	COG0561	phosphatase activity
SLGD_RS11390	COG1428	Deoxynucleoside kinase
SLGD_RS11395	COG1428	Deoxynucleoside kinase
SLGD_RS11415	COG0531	amino acid
SLGD_RS11420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SLGD_RS11455	COG1473	amidohydrolase
SLGD_RS11460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLGD_RS11475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SLGD_RS11485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SLGD_RS11490	COG0085	RNA polymerase activity
SLGD_RS11495	COG2813	Specifically methylates the guanine in position
SLGD_RS11500	COG0222	ribosome binding
SLGD_RS11505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SLGD_RS11510	COG0081	regulation of translation
SLGD_RS11520	COG0250	Participates in transcription elongation, termination and antitermination
SLGD_RS11525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SLGD_RS11535	COG3688	RNA-binding protein containing a PIN domain
SLGD_RS11540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLGD_RS11545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SLGD_RS11550	COG0215	cysteine-tRNA ligase activity
SLGD_RS11555	COG1045	serine acetyltransferase
SLGD_RS11560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLGD_RS11565	COG4956	integral membrane protein (PIN domain superfamily)
SLGD_RS11570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SLGD_RS11575	COG0542	response to heat
SLGD_RS11580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SLGD_RS11585	COG3880	PFAM UvrB UvrC protein
SLGD_RS11590	COG4463	regulation of RNA biosynthetic process
SLGD_RS11595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SLGD_RS11600	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SLGD_RS11605	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SLGD_RS11610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SLGD_RS11695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SLGD_RS11700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SLGD_RS11705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SLGD_RS11715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLGD_RS11725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLGD_RS11740	COG1098	S1 RNA binding domain
SLGD_RS11750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SLGD_RS11755	COG3956	TIGRFAM MazG family protein
SLGD_RS11760	COG2244	polysaccharide biosynthetic process
SLGD_RS11765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SLGD_RS11770	COG0193	aminoacyl-tRNA hydrolase activity
SLGD_RS11780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SLGD_RS11785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SLGD_RS11795	COG0251	oxidation-reduction process
SLGD_RS11800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLGD_RS11805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SLGD_RS11810	COG4466	Protein conserved in bacteria
SLGD_RS11815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SLGD_RS11820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SLGD_RS11825	COG0084	hydrolase, TatD family'
SLGD_RS11830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLGD_RS11830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLGD_RS11835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SLGD_RS11845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SLGD_RS11855	COG1774	PSP1 C-terminal conserved region
SLGD_RS11860	COG0470	DNA polymerase III
SLGD_RS11865	COG3870	Protein conserved in bacteria
SLGD_RS11870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLGD_RS11875	COG1982	Orn Lys Arg decarboxylase major
SLGD_RS11915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SLGD_RS11925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SLGD_RS11935	COG2188	Transcriptional regulator
SLGD_RS11940	COG0366	Alpha amylase catalytic
SLGD_RS11945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLGD_RS11945	COG1263	PTS System
SLGD_RS11955	COG0493	'glutamate synthase
SLGD_RS11960	COG0067	glutamate synthase
SLGD_RS11960	COG0069	glutamate synthase activity
SLGD_RS11960	COG0070	glutamate synthase
SLGD_RS11965	COG0583	DNA-binding transcription factor activity
SLGD_RS12000	COG1464	Belongs to the NlpA lipoprotein family
SLGD_RS12005	COG2011	ABC-type metal ion transport system permease component
SLGD_RS12010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLGD_RS12015	COG1132	(ABC) transporter
SLGD_RS12020	COG2375	cellular response to nickel ion
SLGD_RS12020	COG1132	(ABC) transporter
SLGD_RS12025	COG0626	cystathionine gamma-synthase activity
SLGD_RS12030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLGD_RS12040	COG0733	neurotransmitter:sodium symporter activity
SLGD_RS12060	COG5609	conserved protein (DUF2294)
SLGD_RS12065	COG3002	Belongs to the UPF0753 family
SLGD_RS12070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLGD_RS12080	COG0523	cobalamin synthesis protein
SLGD_RS12100	COG0519	Catalyzes the synthesis of GMP from XMP
SLGD_RS12100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SLGD_RS12105	COG0516	GMP reductase activity
SLGD_RS12105	COG0517	IMP dehydrogenase activity
SLGD_RS12110	COG2233	PERMEase
SLGD_RS12115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLGD_RS12135	COG1823	symporter activity
SLGD_RS12140	COG0778	Nitroreductase
SLGD_RS12150	COG0450	alkyl hydroperoxide reductase
SLGD_RS12155	COG3634	alkyl hydroperoxide reductase activity
SLGD_RS12170	COG0406	alpha-ribazole phosphatase activity
SLGD_RS12205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLGD_RS12215	COG0360	Binds together with S18 to 16S ribosomal RNA
SLGD_RS12230	COG0012	GTP binding
SLGD_RS12235	COG4481	Protein conserved in bacteria
SLGD_RS12240	COG0668	transmembrane transport
SLGD_RS12245	COG1475	DNA binding
SLGD_RS12250	COG0626	cystathionine gamma-synthase activity
SLGD_RS12255	COG0626	cystathionine gamma-synthase activity
SLGD_RS12260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SLGD_RS12260	COG0646	methionine synthase
SLGD_RS12265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SLGD_RS12290	COG0577	efflux transmembrane transporter activity
SLGD_RS12295	COG1136	(ABC) transporter
SLGD_RS12315	COG2205	protein histidine kinase activity
SLGD_RS12330	COG0745	RESPONSE REGULATOR receiver
SLGD_RS12355	COG3878	Protein conserved in bacteria
SLGD_RS12360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLGD_RS12365	COG2271	Major facilitator Superfamily
SLGD_RS12380	COG1136	(ABC) transporter
SLGD_RS12385	COG0577	efflux transmembrane transporter activity
SLGD_RS12395	COG1396	sequence-specific DNA binding
SLGD_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
SLGD_RS12420	COG1063	alcohol dehydrogenase
SLGD_RS12440	COG1475	DNA binding
SLGD_RS12450	COG0445	tRNA wobble uridine modification
SLGD_RS12455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SLGD_RS12460	COG0594	ribonuclease P activity
SLGD_RS12470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SLGD_RS12475	COG0592	DNA-directed DNA polymerase activity
SLGD_RS12480	COG2501	S4 domain
SLGD_RS12485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SLGD_RS12490	COG0187	DNA topoisomerase II activity
SLGD_RS12495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLGD_RS12500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SLGD_RS12510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SLGD_RS12520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SLGD_RS12530	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SLGD_RS12535	COG0359	binds to the 23S rRNA
SLGD_RS12540	COG0305	Participates in initiation and elongation during chromosome replication
SLGD_RS12545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SLGD_RS12560	COG0745	RESPONSE REGULATOR receiver
SLGD_RS12565	COG5002	protein histidine kinase activity
SLGD_RS12570	COG4863	YycH protein
SLGD_RS12605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm