locus-tag	class	description
MRSL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MRSL_RS00010	COG0592	DNA-directed DNA polymerase activity
MRSL_RS00015	COG2501	S4 domain
MRSL_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MRSL_RS00025	COG0187	DNA topoisomerase II activity
MRSL_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MRSL_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MRSL_RS00045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MRSL_RS00055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRSL_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MRSL_RS00070	COG0359	binds to the 23S rRNA
MRSL_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
MRSL_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MRSL_RS00095	COG0745	RESPONSE REGULATOR receiver
MRSL_RS00100	COG5002	protein histidine kinase activity
MRSL_RS00105	COG4863	YycH protein
MRSL_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MRSL_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MRSL_RS00195	COG2113	Glycine betaine
MRSL_RS00200	COG2409	Drug exporters of the RND superfamily
MRSL_RS00210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MRSL_RS00255	COG0584	glycerophosphoryl diester phosphodiesterase
MRSL_RS00260	COG2030	dehydratase
MRSL_RS00335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS00335	COG0463	Glycosyl transferase, family 2
MRSL_RS00475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MRSL_RS00515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRSL_RS00520	COG2210	Belongs to the sulfur carrier protein TusA family
MRSL_RS00525	COG1937	Protein conserved in bacteria
MRSL_RS00530	COG0730	response to heat
MRSL_RS00575	COG1522	sequence-specific DNA binding
MRSL_RS00595	COG1073	alpha beta
MRSL_RS00625	COG1129	ABC transporter
MRSL_RS00660	COG5002	protein histidine kinase activity
MRSL_RS00665	COG0745	RESPONSE REGULATOR receiver
MRSL_RS00675	COG1131	(ABC) transporter
MRSL_RS00735	COG2188	Transcriptional regulator
MRSL_RS00740	COG2222	sugar isomerase
MRSL_RS00745	COG3684	Belongs to the aldolase LacD family
MRSL_RS00750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS00755	COG3715	PTS system
MRSL_RS00760	COG3716	PTS system mannose fructose sorbose family IID component
MRSL_RS00775	COG0745	RESPONSE REGULATOR receiver
MRSL_RS00780	COG2205	protein histidine kinase activity
MRSL_RS00790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MRSL_RS00795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MRSL_RS00820	COG1129	ABC transporter
MRSL_RS00855	COG4509	Sortase family
MRSL_RS00865	COG3942	CHAP domain
MRSL_RS00865	COG1705	Flagellar rod assembly protein muramidase FlgJ
MRSL_RS00870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS00875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS00880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MRSL_RS00885	COG2808	Putative FMN-binding domain
MRSL_RS00895	COG1846	Transcriptional regulator
MRSL_RS00910	COG3842	ATPase activity
MRSL_RS00915	COG4209	transmembrane transport
MRSL_RS00925	COG0395	ABC-type sugar transport system, permease component
MRSL_RS00935	COG0534	Mate efflux family protein
MRSL_RS00940	COG1349	DNA-binding transcription factor activity
MRSL_RS00950	COG5002	protein histidine kinase activity
MRSL_RS00990	COG0583	DNA-binding transcription factor activity
MRSL_RS00995	COG3842	ATPase activity
MRSL_RS01000	COG1840	ABC-type Fe3 transport system, periplasmic component
MRSL_RS01005	COG1177	transmembrane transport
MRSL_RS01010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MRSL_RS01015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MRSL_RS01025	COG1114	Component of the transport system for branched-chain amino acids
MRSL_RS01040	COG0464	growth
MRSL_RS01045	COG0561	phosphatase activity
MRSL_RS01050	COG2814	Major facilitator Superfamily
MRSL_RS01065	COG0601	transmembrane transport
MRSL_RS01075	COG0444	Belongs to the ABC transporter superfamily
MRSL_RS01080	COG1124	(ABC) transporter
MRSL_RS01095	COG0693	protein deglycase activity
MRSL_RS01100	COG0531	amino acid
MRSL_RS01105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRSL_RS01105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRSL_RS01110	COG0505	Belongs to the CarA family
MRSL_RS01155	COG2409	Drug exporters of the RND superfamily
MRSL_RS01155	COG1033	growth of symbiont in host cell
MRSL_RS01175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MRSL_RS01190	COG1131	(ABC) transporter
MRSL_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS01210	COG1278	Cold shock
MRSL_RS01225	COG2311	Membrane
MRSL_RS01230	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MRSL_RS01240	COG1233	COG1233 Phytoene dehydrogenase and related
MRSL_RS01260	COG2814	Major facilitator Superfamily
MRSL_RS01275	COG1131	(ABC) transporter
MRSL_RS01300	COG2264	protein methyltransferase activity
MRSL_RS01305	COG0747	negative chemotaxis
MRSL_RS01310	COG0601	transmembrane transport
MRSL_RS01320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MRSL_RS01325	COG1124	(ABC) transporter
MRSL_RS01330	COG3961	Belongs to the TPP enzyme family
MRSL_RS01345	COG1131	(ABC) transporter
MRSL_RS01355	COG2353	YceI-like domain
MRSL_RS01365	COG1288	antiporter activity
MRSL_RS01375	COG2814	Major facilitator Superfamily
MRSL_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS01405	COG2190	(PTS) system
MRSL_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS01405	COG1263	PTS System
MRSL_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS01435	COG1053	succinate dehydrogenase
MRSL_RS01435	COG3976	FMN-binding domain protein
MRSL_RS01435	COG0431	NADPH-dependent FMN reductase
MRSL_RS01450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MRSL_RS01460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRSL_RS01465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MRSL_RS01470	COG0022	dehydrogenase e1 component
MRSL_RS01480	COG1695	Transcriptional regulator
MRSL_RS01505	COG3711	transcriptional antiterminator
MRSL_RS01505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS01510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MRSL_RS01510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MRSL_RS01510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS01515	COG1482	cell wall glycoprotein biosynthetic process
MRSL_RS01520	COG2124	cytochrome p450
MRSL_RS01530	COG1846	Transcriptional regulator
MRSL_RS01535	COG2814	Major facilitator Superfamily
MRSL_RS01560	COG0706	membrane insertase activity
MRSL_RS01570	COG0531	amino acid
MRSL_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MRSL_RS01650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MRSL_RS01660	COG0363	glucosamine-6-phosphate deaminase activity
MRSL_RS01665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MRSL_RS01680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRSL_RS01685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MRSL_RS01695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MRSL_RS01730	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MRSL_RS01750	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MRSL_RS01755	COG3711	transcriptional antiterminator
MRSL_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS01780	COG3386	PFAM SMP-30 Gluconolaconase
MRSL_RS01795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRSL_RS01805	COG1122	ATPase activity
MRSL_RS01815	COG1476	TRANSCRIPTIONal
MRSL_RS01845	COG1705	Flagellar rod assembly protein muramidase FlgJ
MRSL_RS01845	COG3942	CHAP domain
MRSL_RS01875	COG4974	Belongs to the 'phage' integrase family
MRSL_RS01905	COG3682	Transcriptional regulator
MRSL_RS01915	COG2235	arginine
MRSL_RS01925	COG2843	Capsule synthesis protein
MRSL_RS01930	COG4195	phage-related replication protein
MRSL_RS01935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MRSL_RS01985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MRSL_RS02030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MRSL_RS02035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MRSL_RS02040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MRSL_RS02045	COG1785	Belongs to the alkaline phosphatase family
MRSL_RS02060	COG2205	protein histidine kinase activity
MRSL_RS02065	COG1136	(ABC) transporter
MRSL_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS02100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MRSL_RS02100	COG4932	domain protein
MRSL_RS02100	COG3266	domain, Protein
MRSL_RS02100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MRSL_RS02100	COG3266	domain, Protein
MRSL_RS02100	COG4932	domain protein
MRSL_RS02110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MRSL_RS02115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MRSL_RS02130	COG0730	response to heat
MRSL_RS02135	COG2046	Belongs to the sulfate adenylyltransferase family
MRSL_RS02140	COG0529	Catalyzes the synthesis of activated sulfate
MRSL_RS02155	COG1328	CTP reductase activity
MRSL_RS02160	COG0602	queuosine metabolic process
MRSL_RS02165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MRSL_RS02170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MRSL_RS02175	COG1510	regulation of RNA biosynthetic process
MRSL_RS02180	COG1012	belongs to the aldehyde dehydrogenase family
MRSL_RS02185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRSL_RS02190	COG1473	amidohydrolase
MRSL_RS02205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MRSL_RS02210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MRSL_RS02210	COG0574	Belongs to the PEP-utilizing enzyme family
MRSL_RS02215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MRSL_RS02225	COG2188	Transcriptional regulator
MRSL_RS02230	COG2190	(PTS) system
MRSL_RS02230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS02230	COG1263	PTS System
MRSL_RS02235	COG2723	6-phospho-beta-galactosidase activity
MRSL_RS02245	COG0583	DNA-binding transcription factor activity
MRSL_RS02260	COG3588	fructose-bisphosphate aldolase
MRSL_RS02275	COG1464	Belongs to the NlpA lipoprotein family
MRSL_RS02285	COG0463	Glycosyl transferase, family 2
MRSL_RS02295	COG1215	transferase activity, transferring glycosyl groups
MRSL_RS02295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS02305	COG0531	amino acid
MRSL_RS02310	COG0583	DNA-binding transcription factor activity
MRSL_RS02315	COG0028	Belongs to the TPP enzyme family
MRSL_RS02320	COG3527	Alpha-acetolactate decarboxylase
MRSL_RS02325	COG1620	l-lactate permease
MRSL_RS02345	COG0167	dihydroorotate dehydrogenase activity
MRSL_RS02350	COG3001	Fructosamine kinase
MRSL_RS02355	COG0596	Alpha beta hydrolase
MRSL_RS02405	COG2814	Major facilitator Superfamily
MRSL_RS02415	COG1113	amino acid transport
MRSL_RS02425	COG3189	MarR family transcriptional regulator
MRSL_RS02445	COG0436	Aminotransferase
MRSL_RS02455	COG2608	mercury ion transmembrane transporter activity
MRSL_RS02460	COG2217	Heavy metal translocating P-type atpase
MRSL_RS02470	COG0110	maltose O-acetyltransferase activity
MRSL_RS02475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS02480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRSL_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
MRSL_RS02495	COG2409	Drug exporters of the RND superfamily
MRSL_RS02505	COG0598	Magnesium transport protein CorA
MRSL_RS02510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MRSL_RS02535	COG1131	(ABC) transporter
MRSL_RS02545	COG3425	synthase
MRSL_RS02560	COG3942	CHAP domain
MRSL_RS02560	COG1388	LysM domain
MRSL_RS02570	COG0583	DNA-binding transcription factor activity
MRSL_RS02575	COG1380	Effector of murein hydrolase LrgA
MRSL_RS02580	COG1346	cytolysis
MRSL_RS02585	COG0028	Belongs to the TPP enzyme family
MRSL_RS02600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRSL_RS02605	COG0039	L-malate dehydrogenase activity
MRSL_RS02610	COG0657	acetylesterase activity
MRSL_RS02620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MRSL_RS02645	COG1070	Carbohydrate kinase
MRSL_RS02655	COG1760	l-serine dehydratase
MRSL_RS02660	COG1760	l-serine dehydratase
MRSL_RS02670	COG3764	Sortase (surface protein transpeptidase)
MRSL_RS02680	COG0561	phosphatase activity
MRSL_RS02685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRSL_RS02690	COG0778	Nitroreductase
MRSL_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
MRSL_RS02705	COG2514	catechol 2,3-dioxygenase activity
MRSL_RS02710	COG2388	GCN5-related N-acetyl-transferase
MRSL_RS02725	COG1846	Transcriptional regulator
MRSL_RS02730	COG0346	lactoylglutathione lyase activity
MRSL_RS02735	COG0346	lactoylglutathione lyase activity
MRSL_RS02740	COG0400	carboxylic ester hydrolase activity
MRSL_RS02745	COG3949	Membrane
MRSL_RS02755	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MRSL_RS02760	COG0586	Pfam SNARE associated Golgi protein
MRSL_RS02770	COG2022	thiamine diphosphate biosynthetic process
MRSL_RS02790	COG2271	Major facilitator Superfamily
MRSL_RS02805	COG4876	unkown
MRSL_RS02810	COG2357	RelA SpoT domain protein
MRSL_RS02825	COG1802	Transcriptional regulator
MRSL_RS02830	COG1070	Carbohydrate kinase
MRSL_RS02835	COG2610	gluconate transmembrane transporter activity
MRSL_RS02840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MRSL_RS02855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MRSL_RS02860	COG0438	transferase activity, transferring glycosyl groups
MRSL_RS02865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRSL_RS02880	COG4221	oxidoreductase activity
MRSL_RS02885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRSL_RS02890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MRSL_RS02895	COG0248	Ppx GppA phosphatase
MRSL_RS02900	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MRSL_RS02905	COG1363	Peptidase, m42
MRSL_RS02925	COG3639	organic phosphonate transmembrane transporter activity
MRSL_RS02930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MRSL_RS02945	COG0737	Belongs to the 5'-nucleotidase family
MRSL_RS02950	COG0069	glutamate synthase activity
MRSL_RS02965	COG4619	ABC transporter
MRSL_RS02970	COG0390	transport system, permease component
MRSL_RS02975	COG2205	protein histidine kinase activity
MRSL_RS02980	COG0745	RESPONSE REGULATOR receiver
MRSL_RS02990	COG2814	Major facilitator Superfamily
MRSL_RS02995	COG2272	Belongs to the type-B carboxylesterase lipase family
MRSL_RS03000	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MRSL_RS03005	COG1063	alcohol dehydrogenase
MRSL_RS03025	COG1174	glycine betaine transport
MRSL_RS03055	COG1346	cytolysis
MRSL_RS03060	COG1380	Effector of murein hydrolase LrgA
MRSL_RS03065	COG3279	Response regulator of the LytR AlgR family
MRSL_RS03070	COG3275	phosphorelay sensor kinase activity
MRSL_RS03080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MRSL_RS03085	COG0456	acetyltransferase
MRSL_RS03095	COG0706	membrane insertase activity
MRSL_RS03105	COG0531	amino acid
MRSL_RS03120	COG1113	amino acid transport
MRSL_RS03140	COG2814	Major facilitator Superfamily
MRSL_RS03150	COG1929	Belongs to the glycerate kinase type-1 family
MRSL_RS03160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MRSL_RS03165	COG0741	lytic transglycosylase activity
MRSL_RS03170	COG0588	phosphoglycerate mutase activity
MRSL_RS03180	COG2814	Major facilitator Superfamily
MRSL_RS03185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MRSL_RS03190	COG0765	amino acid transport
MRSL_RS03195	COG1126	abc transporter atp-binding protein
MRSL_RS03235	COG1131	(ABC) transporter
MRSL_RS03245	COG2116	formate transmembrane transporter activity
MRSL_RS03255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MRSL_RS03260	COG2146	nitrite reductase [NAD(P)H] activity
MRSL_RS03270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MRSL_RS03275	COG1140	nitrate reductase beta subunit
MRSL_RS03285	COG2181	nitrate reductase activity
MRSL_RS03295	COG4585	Histidine kinase
MRSL_RS03305	COG2223	nitrite transmembrane transporter activity
MRSL_RS03310	COG1846	Transcriptional regulator
MRSL_RS03350	COG1263	PTS System
MRSL_RS03350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS03375	COG0534	Mate efflux family protein
MRSL_RS03385	COG1124	(ABC) transporter
MRSL_RS03390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MRSL_RS03420	COG0829	nickel cation binding
MRSL_RS03435	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MRSL_RS03440	COG0804	urea catabolic process
MRSL_RS03450	COG0831	urea catabolic process
MRSL_RS03455	COG4413	Urea transporter
MRSL_RS03465	COG4716	Myosin-crossreactive antigen
MRSL_RS03470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MRSL_RS03475	COG2962	Rard protein
MRSL_RS03520	COG2814	Major facilitator Superfamily
MRSL_RS03525	COG0583	DNA-binding transcription factor activity
MRSL_RS03570	COG2314	TM2 domain
MRSL_RS03575	COG0492	ferredoxin-NADP+ reductase activity
MRSL_RS03590	COG0604	alcohol dehydrogenase
MRSL_RS03595	COG2822	iron ion transport
MRSL_RS03600	COG2837	iron assimilation
MRSL_RS03605	COG0672	)-iron permease
MRSL_RS03610	COG0805	protein transport
MRSL_RS03615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MRSL_RS03620	COG0456	acetyltransferase
MRSL_RS03630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS03635	COG1620	l-lactate permease
MRSL_RS03640	COG0297	glycogen (starch) synthase activity
MRSL_RS03645	COG0579	oxidoreductase
MRSL_RS03695	COG2814	Major facilitator Superfamily
MRSL_RS03705	COG1566	PFAM secretion protein HlyD family protein
MRSL_RS03710	COG2814	Major facilitator Superfamily
MRSL_RS03735	COG0598	Magnesium transport protein CorA
MRSL_RS03740	COG1304	FMN binding
MRSL_RS03745	COG2094	Belongs to the DNA glycosylase MPG family
MRSL_RS03755	COG2017	converts alpha-aldose to the beta-anomer
MRSL_RS03760	COG2258	MOSC domain
MRSL_RS03765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MRSL_RS03770	COG1266	CAAX protease self-immunity
MRSL_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS03800	COG1737	Transcriptional regulator
MRSL_RS03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS03805	COG1263	PTS System
MRSL_RS03815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MRSL_RS03835	COG1113	amino acid transport
MRSL_RS03840	COG1737	Transcriptional regulator
MRSL_RS03845	COG1263	PTS System
MRSL_RS03845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS03850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MRSL_RS03860	COG1349	DNA-binding transcription factor activity
MRSL_RS03870	COG1316	TRANSCRIPTIONal
MRSL_RS03895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRSL_RS03900	COG2076	Multidrug Resistance protein
MRSL_RS03905	COG2076	Multidrug Resistance protein
MRSL_RS03910	COG3942	CHAP domain
MRSL_RS03925	COG1757	Na H antiporter
MRSL_RS03930	COG3942	CHAP domain
MRSL_RS03960	COG1960	acyl-CoA dehydrogenase activity
MRSL_RS03965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MRSL_RS03975	COG1268	BioY protein
MRSL_RS03985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MRSL_RS03990	COG0725	ABC transporter, periplasmic molybdate-binding protein
MRSL_RS03995	COG4149	molybdate abc transporter
MRSL_RS04000	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MRSL_RS04005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MRSL_RS04040	COG0746	molybdenum cofactor guanylyltransferase activity
MRSL_RS04045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MRSL_RS04070	COG2348	transferase activity, transferring amino-acyl groups
MRSL_RS04075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MRSL_RS04105	COG2252	PERMEase
MRSL_RS04120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MRSL_RS04125	COG0088	Forms part of the polypeptide exit tunnel
MRSL_RS04130	COG0089	rRNA binding
MRSL_RS04135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MRSL_RS04140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MRSL_RS04150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MRSL_RS04155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MRSL_RS04165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MRSL_RS04175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MRSL_RS04190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MRSL_RS04195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MRSL_RS04200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MRSL_RS04205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MRSL_RS04210	COG1841	ribosomal large subunit assembly
MRSL_RS04220	COG0201	protein transport
MRSL_RS04225	COG0563	adenylate kinase activity
MRSL_RS04230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MRSL_RS04235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MRSL_RS04240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MRSL_RS04250	COG0202	RNA polymerase activity
MRSL_RS04255	COG0203	ribosomal protein L17
MRSL_RS04265	COG1122	ATPase activity
MRSL_RS04275	COG0101	tRNA pseudouridine synthase activity
MRSL_RS04280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MRSL_RS04305	COG1131	(ABC) transporter
MRSL_RS04315	COG1131	(ABC) transporter
MRSL_RS04325	COG1309	transcriptional regulator
MRSL_RS04380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MRSL_RS04385	COG1349	DNA-binding transcription factor activity
MRSL_RS04390	COG0698	ribose 5-phosphate isomerase
MRSL_RS04395	COG0698	ribose 5-phosphate isomerase
MRSL_RS04400	COG1105	Belongs to the carbohydrate kinase PfkB family
MRSL_RS04405	COG3684	Belongs to the aldolase LacD family
MRSL_RS04410	COG1447	Phosphotransferase system cellobiose-specific component IIA
MRSL_RS04415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MRSL_RS04415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MRSL_RS04420	COG2723	6-phospho-beta-galactosidase activity
MRSL_RS04430	COG2130	NADP-dependent
MRSL_RS04435	COG0604	alcohol dehydrogenase
MRSL_RS04465	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MRSL_RS04470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS04475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS04490	COG1988	membrane-bound metal-dependent
MRSL_RS04495	COG4284	Utp--glucose-1-phosphate uridylyltransferase
MRSL_RS04500	COG1272	protein, Hemolysin III
MRSL_RS04515	COG2814	Major facilitator Superfamily
MRSL_RS04520	COG0489	protein tyrosine kinase activity
MRSL_RS04590	COG0561	phosphatase activity
MRSL_RS04610	COG0640	Transcriptional regulator
MRSL_RS04615	COG0702	epimerase
MRSL_RS04620	COG1482	cell wall glycoprotein biosynthetic process
MRSL_RS04640	COG0783	Belongs to the Dps family
MRSL_RS04645	COG0813	purine-nucleoside phosphorylase activity
MRSL_RS04650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MRSL_RS04655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MRSL_RS04660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MRSL_RS04685	COG1854	S-ribosylhomocysteine lyase activity
MRSL_RS04705	COG5146	pantothenate kinase activity
MRSL_RS04715	COG3343	RNA polymerase activity
MRSL_RS04720	COG0504	CTP synthase activity
MRSL_RS04730	COG0191	fructose-bisphosphate aldolase activity
MRSL_RS04735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MRSL_RS04745	COG1012	belongs to the aldehyde dehydrogenase family
MRSL_RS04750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MRSL_RS04755	COG0254	rRNA binding
MRSL_RS04765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MRSL_RS04770	COG2890	protein-(glutamine-N5) methyltransferase activity
MRSL_RS04775	COG0009	L-threonylcarbamoyladenylate synthase
MRSL_RS04785	COG4475	Protein of unknown function (DUF436)
MRSL_RS04790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MRSL_RS04805	COG0356	it plays a direct role in the translocation of protons across the membrane
MRSL_RS04810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MRSL_RS04815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MRSL_RS04820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MRSL_RS04830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MRSL_RS04835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MRSL_RS04845	COG4836	Membrane
MRSL_RS04850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MRSL_RS04855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MRSL_RS04890	COG0629	single-stranded DNA binding
MRSL_RS04900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MRSL_RS04910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MRSL_RS04915	COG0352	thiamine-phosphate diphosphorylase activity
MRSL_RS04920	COG0706	membrane insertase activity
MRSL_RS04930	COG1418	mRNA catabolic process
MRSL_RS04935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MRSL_RS04940	COG1937	Protein conserved in bacteria
MRSL_RS04955	COG0772	Belongs to the SEDS family
MRSL_RS04960	COG1181	Belongs to the D-alanine--D-alanine ligase family
MRSL_RS04965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MRSL_RS04970	COG0513	Belongs to the DEAD box helicase family
MRSL_RS04980	COG3428	Bacterial PH domain
MRSL_RS04990	COG0736	holo-[acyl-carrier-protein] synthase activity
MRSL_RS05005	COG2337	Toxic component of a toxin-antitoxin (TA) module
MRSL_RS05010	COG2208	phosphoserine phosphatase activity
MRSL_RS05025	COG1191	sigma factor activity
MRSL_RS05030	COG2183	response to ionizing radiation
MRSL_RS05070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRSL_RS05080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRSL_RS05090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRSL_RS05095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MRSL_RS05105	COG0028	Belongs to the TPP enzyme family
MRSL_RS05115	COG0802	atpase or kinase
MRSL_RS05120	COG1214	PFAM Peptidase M22, glycoprotease
MRSL_RS05125	COG0456	acetyltransferase
MRSL_RS05130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MRSL_RS05135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRSL_RS05140	COG0488	(ABC) transporter
MRSL_RS05145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MRSL_RS05150	COG2391	methyltransferase activity
MRSL_RS05155	COG0425	Belongs to the sulfur carrier protein TusA family
MRSL_RS05160	COG0004	ammonium transporteR
MRSL_RS05165	COG1609	Transcriptional regulator
MRSL_RS05170	COG1621	beta-fructofuranosidase activity
MRSL_RS05175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRSL_RS05185	COG3290	protein histidine kinase activity
MRSL_RS05195	COG4512	PFAM Accessory gene regulator B
MRSL_RS05200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MRSL_RS05225	COG0459	protein refolding
MRSL_RS05230	COG0582	viral genome integration into host DNA
MRSL_RS05300	COG5484	DNA packaging
MRSL_RS05300	COG3728	DNA packaging
MRSL_RS05320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MRSL_RS05325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MRSL_RS05330	COG0436	Aminotransferase
MRSL_RS05340	COG1725	Transcriptional regulator
MRSL_RS05345	COG1129	ABC transporter
MRSL_RS05345	COG0842	Transport permease protein
MRSL_RS05355	COG1131	(ABC) transporter
MRSL_RS05395	COG2706	6-phosphogluconolactonase activity
MRSL_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
MRSL_RS05415	COG0456	acetyltransferase
MRSL_RS05425	COG1227	inorganic diphosphatase activity
MRSL_RS05430	COG1335	isochorismatase
MRSL_RS05445	COG0077	Prephenate dehydratase
MRSL_RS05455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MRSL_RS05460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MRSL_RS05465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MRSL_RS05475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MRSL_RS05480	COG4496	protein, YerC YecD
MRSL_RS05485	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MRSL_RS05495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MRSL_RS05500	COG4851	CamS sex pheromone cAM373 precursor
MRSL_RS05510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MRSL_RS05520	COG0154	amidase activity
MRSL_RS05525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MRSL_RS05530	COG1597	lipid kinase activity
MRSL_RS05535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MRSL_RS05560	COG1528	Iron-storage protein
MRSL_RS05580	COG0446	pyridine nucleotide-disulphide oxidoreductase
MRSL_RS05585	COG4129	membrane
MRSL_RS05590	COG0024	Methionine aminopeptidase
MRSL_RS05615	COG1295	ribonuclease BN
MRSL_RS05625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MRSL_RS05630	COG4840	Belongs to the UPF0435 family
MRSL_RS05635	COG2309	aminopeptidase activity
MRSL_RS05640	COG1607	acyl-coa hydrolase
MRSL_RS05645	COG0535	radical SAM domain protein
MRSL_RS05655	COG0693	protein deglycase activity
MRSL_RS05660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MRSL_RS05665	COG2137	regulation of response to DNA damage stimulus
MRSL_RS05675	COG1134	teichoic acid transport
MRSL_RS05675	COG1388	LysM domain
MRSL_RS05685	COG1988	membrane-bound metal-dependent
MRSL_RS05690	COG1194	a g-specific adenine glycosylase
MRSL_RS05695	COG3557	Belongs to the UPF0374 family
MRSL_RS05705	COG4129	membrane
MRSL_RS05710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MRSL_RS05715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MRSL_RS05725	COG0735	belongs to the Fur family
MRSL_RS05900	COG0765	amino acid transport
MRSL_RS05905	COG1126	abc transporter atp-binding protein
MRSL_RS05910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MRSL_RS05920	COG0363	glucosamine-6-phosphate deaminase activity
MRSL_RS05935	COG0114	fumarate hydratase activity
MRSL_RS05940	COG0564	pseudouridine synthase activity
MRSL_RS05945	COG4585	Histidine kinase
MRSL_RS05945	COG2203	Gaf domain
MRSL_RS05950	COG2197	response regulator
MRSL_RS05965	COG3679	Belongs to the UPF0342 family
MRSL_RS05970	COG0420	3'-5' exonuclease activity
MRSL_RS05990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MRSL_RS06005	COG0537	adenosine 5'-monophosphoramidase activity
MRSL_RS06010	COG1131	(ABC) transporter
MRSL_RS06015	COG4473	ABC transporter
MRSL_RS06020	COG2329	Antibiotic biosynthesis monooxygenase
MRSL_RS06025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MRSL_RS06040	COG3545	Serine hydrolase
MRSL_RS06090	COG0318	PFAM AMP-dependent synthetase and ligase
MRSL_RS06100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MRSL_RS06110	COG1506	peptidase
MRSL_RS06115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MRSL_RS06120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MRSL_RS06130	COG0656	L-ascorbic acid biosynthetic process
MRSL_RS06135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MRSL_RS06150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MRSL_RS06175	COG5632	N-Acetylmuramoyl-L-alanine amidase
MRSL_RS06175	COG3266	domain, Protein
MRSL_RS06175	COG4193	domain, Protein
MRSL_RS06185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRSL_RS06185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRSL_RS06195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRSL_RS06195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRSL_RS06200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MRSL_RS06205	COG0506	proline dehydrogenase activity
MRSL_RS06210	COG2267	carboxylic ester hydrolase activity
MRSL_RS06220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MRSL_RS06225	COG1242	4 iron, 4 sulfur cluster binding
MRSL_RS06230	COG2814	Major facilitator Superfamily
MRSL_RS06235	COG0495	leucyl-tRNA aminoacylation
MRSL_RS06245	COG2081	HI0933 family
MRSL_RS06250	COG2244	polysaccharide biosynthetic process
MRSL_RS06255	COG1187	pseudouridine synthase activity
MRSL_RS06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRSL_RS06275	COG0510	thiamine kinase activity
MRSL_RS06280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MRSL_RS06285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRSL_RS06290	COG5584	Small secreted protein
MRSL_RS06295	COG1363	Peptidase, m42
MRSL_RS06300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRSL_RS06305	COG4848	Belongs to the UPF0354 family
MRSL_RS06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRSL_RS06315	COG1674	ftsk spoiiie
MRSL_RS06320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MRSL_RS06325	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MRSL_RS06335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MRSL_RS06335	COG1605	Chorismate mutase
MRSL_RS06340	COG1609	Transcriptional regulator
MRSL_RS06355	COG0123	including yeast histone deacetylase and acetoin utilization protein
MRSL_RS06360	COG0454	-acetyltransferase
MRSL_RS06365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MRSL_RS06370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MRSL_RS06380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MRSL_RS06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRSL_RS06390	COG0204	Acyl-transferase
MRSL_RS06395	COG1263	PTS System
MRSL_RS06395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS06405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRSL_RS06410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MRSL_RS06415	COG1764	response to oxidative stress
MRSL_RS06420	COG0584	glycerophosphoryl diester phosphodiesterase
MRSL_RS06425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MRSL_RS06430	COG1956	GAF domain-containing protein
MRSL_RS06435	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MRSL_RS06440	COG1104	cysteine desulfurase activity
MRSL_RS06445	COG0301	tRNA thio-modification
MRSL_RS06450	COG0730	response to heat
MRSL_RS06455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MRSL_RS06460	COG0827	DNA restriction-modification system
MRSL_RS06465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MRSL_RS06470	COG0589	response to stress
MRSL_RS06475	COG0686	Belongs to the AlaDH PNT family
MRSL_RS06480	COG0006	proline dipeptidase activity
MRSL_RS06485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MRSL_RS06500	COG4109	DRTGG domain
MRSL_RS06505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MRSL_RS06510	COG0587	DNA-directed DNA polymerase activity
MRSL_RS06515	COG0281	malic enzyme
MRSL_RS06520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MRSL_RS06525	COG0825	malonyl-CoA metabolic process
MRSL_RS06530	COG0205	6-phosphofructokinase activity
MRSL_RS06535	COG0469	pyruvate kinase activity
MRSL_RS06545	COG1113	amino acid transport
MRSL_RS06550	COG0372	Belongs to the citrate synthase family
MRSL_RS06555	COG0538	isocitrate dehydrogenase activity
MRSL_RS06560	COG0745	RESPONSE REGULATOR receiver
MRSL_RS06565	COG5002	protein histidine kinase activity
MRSL_RS06570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRSL_RS06570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRSL_RS06575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MRSL_RS06580	COG0237	dephospho-CoA kinase activity
MRSL_RS06585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MRSL_RS06590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MRSL_RS06595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MRSL_RS06600	COG3611	Membrane attachment protein
MRSL_RS06605	COG1484	DNA-dependent DNA replication
MRSL_RS06615	COG0833	amino acid
MRSL_RS06620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MRSL_RS06625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MRSL_RS06630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MRSL_RS06635	COG4112	unkown
MRSL_RS06645	COG0544	peptidyl-prolyl cis-trans isomerase activity
MRSL_RS06650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MRSL_RS06665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MRSL_RS06670	COG0181	hydroxymethylbilane synthase activity
MRSL_RS06685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MRSL_RS06695	COG2818	Glycosylase
MRSL_RS06700	COG0525	valine-tRNA ligase activity
MRSL_RS06705	COG0285	dihydrofolate synthase activity
MRSL_RS06715	COG2003	Belongs to the UPF0758 family
MRSL_RS06730	COG1792	Involved in formation and maintenance of cell shape
MRSL_RS06740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MRSL_RS06745	COG2868	ribosomal protein
MRSL_RS06755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MRSL_RS06760	COG4492	Belongs to the UPF0735 family
MRSL_RS06765	COG0632	four-way junction helicase activity
MRSL_RS06770	COG2255	four-way junction helicase activity
MRSL_RS06775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MRSL_RS06780	COG0343	queuine tRNA-ribosyltransferase activity
MRSL_RS06785	COG1862	Preprotein translocase
MRSL_RS06790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MRSL_RS06790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MRSL_RS06795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MRSL_RS06795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MRSL_RS06805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MRSL_RS06810	COG1490	D-aminoacyl-tRNA deacylase activity
MRSL_RS06815	COG0860	N-Acetylmuramoyl-L-alanine amidase
MRSL_RS06820	COG0124	histidyl-tRNA synthetase
MRSL_RS06825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MRSL_RS06835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MRSL_RS06840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MRSL_RS06845	COG1959	2 iron, 2 sulfur cluster binding
MRSL_RS06855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MRSL_RS06860	COG1104	cysteine desulfurase activity
MRSL_RS06865	COG0482	sulfurtransferase activity
MRSL_RS06875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MRSL_RS06880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MRSL_RS06885	COG4472	Bacterial protein of unknown function (DUF965)
MRSL_RS06890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MRSL_RS06900	COG4122	O-methyltransferase activity
MRSL_RS06915	COG0572	uridine kinase
MRSL_RS06920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MRSL_RS06925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MRSL_RS06930	COG1984	allophanate hydrolase subunit 2
MRSL_RS06935	COG0511	ligase activity, forming carbon-carbon bonds
MRSL_RS06940	COG0439	Biotin carboxylase
MRSL_RS06950	COG1914	H( )-stimulated, divalent metal cation uptake system
MRSL_RS06955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MRSL_RS06960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MRSL_RS06965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MRSL_RS06975	COG1534	Rna-binding protein
MRSL_RS06980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MRSL_RS06985	COG1713	HD superfamily hydrolase involved in NAD metabolism
MRSL_RS06990	COG0799	negative regulation of ribosome biogenesis
MRSL_RS06995	COG2226	methyltransferase
MRSL_RS07000	COG1555	photosystem II stabilization
MRSL_RS07000	COG1596	polysaccharide export
MRSL_RS07005	COG2131	deaminase
MRSL_RS07010	COG0658	competence protein
MRSL_RS07010	COG2333	competence protein COMEC
MRSL_RS07015	COG1466	dna polymerase III delta subunit
MRSL_RS07020	COG0268	Binds directly to 16S ribosomal RNA
MRSL_RS07025	COG0481	GTPase activity
MRSL_RS07030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MRSL_RS07040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MRSL_RS07045	COG0443	Heat shock 70 kDa protein
MRSL_RS07050	COG0484	heat shock protein binding
MRSL_RS07055	COG2264	protein methyltransferase activity
MRSL_RS07060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MRSL_RS07065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MRSL_RS07075	COG1030	water channel activity
MRSL_RS07080	COG4864	UPF0365 protein
MRSL_RS07090	COG1702	phosphate starvation-inducible protein PhoH
MRSL_RS07095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MRSL_RS07100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MRSL_RS07105	COG0295	cytidine deaminase activity
MRSL_RS07110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MRSL_RS07115	COG1381	Involved in DNA repair and RecF pathway recombination
MRSL_RS07120	COG0423	glycine-tRNA ligase activity
MRSL_RS07125	COG0517	IMP dehydrogenase activity
MRSL_RS07130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MRSL_RS07145	COG2384	SAM-dependent methyltransferase
MRSL_RS07155	COG0513	Belongs to the DEAD box helicase family
MRSL_RS07160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MRSL_RS07165	COG1121	(ABC) transporter
MRSL_RS07170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MRSL_RS07180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MRSL_RS07190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MRSL_RS07195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MRSL_RS07200	COG0705	Rhomboid family
MRSL_RS07200	COG0457	Tetratricopeptide repeat
MRSL_RS07205	COG4483	Protein conserved in bacteria
MRSL_RS07210	COG1940	carbohydrate kinase activity
MRSL_RS07215	COG0011	TIGRFAM Protein of
MRSL_RS07220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRSL_RS07225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MRSL_RS07230	COG1459	type II secretion system
MRSL_RS07235	COG4537	Required for transformation and DNA binding
MRSL_RS07255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MRSL_RS07260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MRSL_RS07265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MRSL_RS07270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MRSL_RS07275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MRSL_RS07280	COG0095	Lipoate-protein ligase
MRSL_RS07295	COG0006	proline dipeptidase activity
MRSL_RS07300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MRSL_RS07305	COG0511	ligase activity, forming carbon-carbon bonds
MRSL_RS07310	COG0439	Biotin carboxylase
MRSL_RS07315	COG1302	Protein conserved in bacteria
MRSL_RS07320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MRSL_RS07340	COG1438	arginine binding
MRSL_RS07345	COG0497	DNA recombination
MRSL_RS07350	COG0280	phosphate acetyltransferase
MRSL_RS07355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRSL_RS07360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MRSL_RS07365	COG0022	dehydrogenase e1 component
MRSL_RS07370	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRSL_RS07380	COG4129	membrane
MRSL_RS07395	COG2195	Cleaves the N-terminal amino acid of tripeptides
MRSL_RS07405	COG1609	Transcriptional regulator
MRSL_RS07410	COG0366	Alpha amylase catalytic
MRSL_RS07420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MRSL_RS07430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MRSL_RS07435	COG0300	oxidoreductase activity
MRSL_RS07445	COG0667	Aldo Keto reductase
MRSL_RS07450	COG0494	nUDIX hydrolase
MRSL_RS07455	COG0735	belongs to the Fur family
MRSL_RS07460	COG4974	Belongs to the 'phage' integrase family
MRSL_RS07470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MRSL_RS07475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MRSL_RS07480	COG1187	pseudouridine synthase activity
MRSL_RS07485	COG0745	RESPONSE REGULATOR receiver
MRSL_RS07500	COG1141	Ferredoxin
MRSL_RS07510	COG0514	ATP-dependent DNA helicase (RecQ)
MRSL_RS07515	COG1388	LysM domain
MRSL_RS07520	COG0492	ferredoxin-NADP+ reductase activity
MRSL_RS07540	COG0539	negative regulation of cytoplasmic translation
MRSL_RS07550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MRSL_RS07565	COG2226	methyltransferase
MRSL_RS07570	COG0142	geranyltranstransferase activity
MRSL_RS07580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MRSL_RS07585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MRSL_RS07610	COG2738	Putative neutral zinc metallopeptidase
MRSL_RS07615	COG1694	Mazg nucleotide pyrophosphohydrolase
MRSL_RS07620	COG0438	transferase activity, transferring glycosyl groups
MRSL_RS07625	COG0617	tRNA 3'-terminal CCA addition
MRSL_RS07630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MRSL_RS07630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MRSL_RS07635	COG1199	ATP-dependent helicase activity
MRSL_RS07635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MRSL_RS07640	COG0017	Asparaginyl-tRNA synthetase
MRSL_RS07645	COG3935	DnaD domain protein
MRSL_RS07650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MRSL_RS07660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MRSL_RS07660	COG4499	WXG100 protein secretion system (Wss), protein YukC
MRSL_RS07675	COG4474	Belongs to the UPF0398 family
MRSL_RS07680	COG3599	regulation of cell shape
MRSL_RS07690	COG0116	Belongs to the methyltransferase superfamily
MRSL_RS07700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MRSL_RS07705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRSL_RS07710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MRSL_RS07715	COG0512	Glutamine amidotransferase of anthranilate synthase
MRSL_RS07720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MRSL_RS07725	COG0134	indole-3-glycerol-phosphate synthase activity
MRSL_RS07730	COG0135	phosphoribosylanthranilate isomerase activity
MRSL_RS07745	COG2348	transferase activity, transferring amino-acyl groups
MRSL_RS07755	COG0561	phosphatase activity
MRSL_RS07760	COG4607	ABC-type enterochelin transport system periplasmic component
MRSL_RS07770	COG1164	Oligoendopeptidase f
MRSL_RS07780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MRSL_RS07785	COG0581	inorganic phosphate transmembrane transporter activity
MRSL_RS07790	COG0573	inorganic phosphate transmembrane transporter activity
MRSL_RS07795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MRSL_RS07800	COG2996	Protein conserved in bacteria
MRSL_RS07805	COG0488	(ABC) transporter
MRSL_RS07810	COG0527	aspartate kinase activity
MRSL_RS07815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MRSL_RS07820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRSL_RS07825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MRSL_RS07830	COG2171	N-acyltransferase activity
MRSL_RS07835	COG1473	amidohydrolase
MRSL_RS07855	COG1278	Cold shock
MRSL_RS07865	COG1254	Belongs to the acylphosphatase family
MRSL_RS07875	COG3853	Toxic anion resistance protein (TelA)
MRSL_RS07880	COG1114	Component of the transport system for branched-chain amino acids
MRSL_RS07885	COG4548	von Willebrand factor, type A
MRSL_RS07890	COG0714	Associated with various cellular activities
MRSL_RS07910	COG0567	Dehydrogenase, E1 component
MRSL_RS07915	COG5002	protein histidine kinase activity
MRSL_RS07920	COG0745	RESPONSE REGULATOR receiver
MRSL_RS07925	COG0671	phosphoesterase, PA-phosphatase related
MRSL_RS07930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MRSL_RS07940	COG0793	Belongs to the peptidase S41A family
MRSL_RS07945	COG4479	Belongs to the UPF0346 family
MRSL_RS07955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRSL_RS07985	COG1413	lyase activity
MRSL_RS07995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MRSL_RS08000	COG0328	RNA-DNA hybrid ribonuclease activity
MRSL_RS08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS08030	COG3623	hexulose-6-phosphate isomerase
MRSL_RS08050	COG0287	Prephenate dehydrogenase
MRSL_RS08055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MRSL_RS08060	COG1942	4-Oxalocrotonate Tautomerase
MRSL_RS08095	COG0392	lysyltransferase activity
MRSL_RS08095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MRSL_RS08100	COG0628	permease
MRSL_RS08105	COG1115	amino acid carrier protein
MRSL_RS08110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MRSL_RS08115	COG0187	DNA topoisomerase II activity
MRSL_RS08120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MRSL_RS08125	COG4841	protein insertion into membrane
MRSL_RS08135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MRSL_RS08140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MRSL_RS08145	COG1970	mechanosensitive ion channel activity
MRSL_RS08150	COG0419	ATPase involved in DNA repair
MRSL_RS08160	COG4846	Membrane protein involved in cytochrome C biogenesis
MRSL_RS08165	COG3763	UPF0154 protein
MRSL_RS08170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MRSL_RS08175	COG4224	UPF0291 protein
MRSL_RS08185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MRSL_RS08190	COG2340	Cysteine-rich secretory protein family
MRSL_RS08200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MRSL_RS08215	COG0833	amino acid
MRSL_RS08225	COG0561	phosphatase activity
MRSL_RS08230	COG0083	homoserine kinase activity
MRSL_RS08235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MRSL_RS08240	COG0460	homoserine dehydrogenase
MRSL_RS08260	COG1525	nuclease
MRSL_RS08275	COG2197	response regulator
MRSL_RS08280	COG4585	Histidine kinase
MRSL_RS08280	COG2203	Gaf domain
MRSL_RS08290	COG1131	(ABC) transporter
MRSL_RS08295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MRSL_RS08310	COG0789	Transcriptional regulator
MRSL_RS08315	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MRSL_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MRSL_RS08330	COG1923	regulation of RNA biosynthetic process
MRSL_RS08335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MRSL_RS08345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MRSL_RS08350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MRSL_RS08355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MRSL_RS08365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MRSL_RS08370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRSL_RS08385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MRSL_RS08395	COG4195	phage-related replication protein
MRSL_RS08400	COG1013	pyruvate-flavodoxin oxidoreductase activity
MRSL_RS08405	COG0674	pyruvate-flavodoxin oxidoreductase activity
MRSL_RS08405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MRSL_RS08410	COG1692	metallophosphoesterase
MRSL_RS08420	COG1418	mRNA catabolic process
MRSL_RS08425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MRSL_RS08430	COG1058	Belongs to the CinA family
MRSL_RS08430	COG1546	Belongs to the CinA family
MRSL_RS08450	COG0300	oxidoreductase activity
MRSL_RS08455	COG0612	Peptidase, M16
MRSL_RS08460	COG0612	Peptidase, M16
MRSL_RS08465	COG2188	Transcriptional regulator
MRSL_RS08470	COG1674	ftsk spoiiie
MRSL_RS08475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MRSL_RS08480	COG1185	polyribonucleotide nucleotidyltransferase activity
MRSL_RS08490	COG0196	riboflavin kinase activity
MRSL_RS08500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MRSL_RS08505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MRSL_RS08510	COG1358	cellular component organization or biogenesis
MRSL_RS08515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MRSL_RS08520	COG0195	Participates in both transcription termination and antitermination
MRSL_RS08525	COG0779	Required for maturation of 30S ribosomal subunits
MRSL_RS08530	COG2176	DNA-directed DNA polymerase activity
MRSL_RS08535	COG0442	prolyl-tRNA aminoacylation
MRSL_RS08550	COG4589	Belongs to the CDS family
MRSL_RS08555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MRSL_RS08560	COG0233	cytoplasmic translational termination
MRSL_RS08565	COG0528	UMP kinase activity
MRSL_RS08570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MRSL_RS08575	COG0052	Belongs to the universal ribosomal protein uS2 family
MRSL_RS08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MRSL_RS08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MRSL_RS08590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MRSL_RS08595	COG4974	Belongs to the 'phage' integrase family
MRSL_RS08600	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MRSL_RS08605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MRSL_RS08610	COG0758	DNA mediated transformation
MRSL_RS08615	COG2348	transferase activity, transferring amino-acyl groups
MRSL_RS08620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MRSL_RS08625	COG0045	succinate-CoA ligase (ADP-forming) activity
MRSL_RS08630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MRSL_RS08640	COG4485	Bacterial membrane protein, YfhO
MRSL_RS08650	COG0335	large ribosomal subunit rRNA binding
MRSL_RS08655	COG0336	Belongs to the RNA methyltransferase TrmD family
MRSL_RS08660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MRSL_RS08665	COG0228	four-way junction DNA binding
MRSL_RS08680	COG0183	Belongs to the thiolase family
MRSL_RS08685	COG0318	PFAM AMP-dependent synthetase and ligase
MRSL_RS08695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MRSL_RS08700	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MRSL_RS08705	COG0552	protein localization to endoplasmic reticulum
MRSL_RS08710	COG1196	nuclear chromosome segregation
MRSL_RS08715	COG0571	ribonuclease III activity
MRSL_RS08720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MRSL_RS08735	COG0416	fatty acid biosynthetic process
MRSL_RS08740	COG1349	DNA-binding transcription factor activity
MRSL_RS08745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MRSL_RS08750	COG1461	Dihydroxyacetone kinase
MRSL_RS08755	COG1302	Protein conserved in bacteria
MRSL_RS08760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MRSL_RS08770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MRSL_RS08785	COG0631	protein serine/threonine phosphatase activity
MRSL_RS08795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MRSL_RS08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MRSL_RS08800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MRSL_RS08810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MRSL_RS08815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MRSL_RS08820	COG1758	RNA polymerase activity
MRSL_RS08825	COG0194	GDP metabolic process
MRSL_RS08845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MRSL_RS08850	COG0284	orotidine-5'-phosphate decarboxylase activity
MRSL_RS08860	COG0505	Belongs to the CarA family
MRSL_RS08870	COG0540	Belongs to the ATCase OTCase family
MRSL_RS08875	COG2233	PERMEase
MRSL_RS08880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MRSL_RS08885	COG0564	pseudouridine synthase activity
MRSL_RS08890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MRSL_RS08900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MRSL_RS08905	COG3599	regulation of cell shape
MRSL_RS08910	COG2302	S4 RNA-binding domain
MRSL_RS08915	COG0762	integral membrane protein
MRSL_RS08920	COG1799	cell septum assembly
MRSL_RS08925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MRSL_RS08935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MRSL_RS08940	COG0849	cell division
MRSL_RS08945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MRSL_RS08950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MRSL_RS08955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MRSL_RS08965	COG4839	cell division protein FtsL
MRSL_RS08970	COG0275	rRNA processing
MRSL_RS08980	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MRSL_RS08985	COG0454	-acetyltransferase
MRSL_RS08995	COG1011	Hydrolase
MRSL_RS09005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MRSL_RS09010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MRSL_RS09015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MRSL_RS09020	COG1053	succinate dehydrogenase
MRSL_RS09025	COG2009	succinate dehydrogenase
MRSL_RS09030	COG0322	excinuclease ABC activity
MRSL_RS09035	COG3118	belongs to the thioredoxin family
MRSL_RS09040	COG1193	negative regulation of DNA recombination
MRSL_RS09045	COG1796	DNA polymerase
MRSL_RS09045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MRSL_RS09055	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MRSL_RS09060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MRSL_RS09065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRSL_RS09065	COG0072	phenylalanine-tRNA ligase activity
MRSL_RS09070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MRSL_RS09075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MRSL_RS09080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MRSL_RS09090	COG1323	Belongs to the UPF0348 family
MRSL_RS09095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MRSL_RS09100	COG0742	ribosomal rna small subunit methyltransferase
MRSL_RS09120	COG3679	Belongs to the UPF0342 family
MRSL_RS09135	COG0109	protoheme IX farnesyltransferase activity
MRSL_RS09140	COG1612	heme a metabolic process
MRSL_RS09160	COG0772	Belongs to the SEDS family
MRSL_RS09165	COG4838	Belongs to the UPF0358 family
MRSL_RS09170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MRSL_RS09190	COG0483	inositol monophosphate 1-phosphatase activity
MRSL_RS09195	COG4493	Belongs to the UPF0637 family
MRSL_RS09215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MRSL_RS09220	COG1177	transmembrane transport
MRSL_RS09240	COG4476	Belongs to the UPF0223 family
MRSL_RS09255	COG0022	dehydrogenase e1 component
MRSL_RS09270	COG0242	peptide deformylase activity
MRSL_RS09280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MRSL_RS09290	COG0569	domain protein
MRSL_RS09305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MRSL_RS09320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MRSL_RS09335	COG4172	Belongs to the ABC transporter superfamily
MRSL_RS09340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MRSL_RS09345	COG0151	Belongs to the GarS family
MRSL_RS09350	COG0138	bifunctional purine biosynthesis protein purh
MRSL_RS09360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MRSL_RS09370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MRSL_RS09375	COG0047	phosphoribosylformylglycinamidine synthase activity
MRSL_RS09380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MRSL_RS09385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MRSL_RS09390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MRSL_RS09395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MRSL_RS09400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MRSL_RS09405	COG1017	nitric oxide dioxygenase activity
MRSL_RS09405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MRSL_RS09415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MRSL_RS09425	COG1845	cytochrome c oxidase, subunit III
MRSL_RS09430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MRSL_RS09440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MRSL_RS09445	COG1316	TRANSCRIPTIONal
MRSL_RS09470	COG3594	Acyltransferase
MRSL_RS09475	COG0436	Aminotransferase
MRSL_RS09480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MRSL_RS09485	COG0596	Alpha beta hydrolase
MRSL_RS09490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MRSL_RS09495	COG1169	isochorismate synthase
MRSL_RS09500	COG1575	Belongs to the MenA family. Type 1 subfamily
MRSL_RS09570	COG4873	Protein conserved in bacteria
MRSL_RS09580	COG0737	Belongs to the 5'-nucleotidase family
MRSL_RS09585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MRSL_RS09595	COG0861	Integral membrane protein TerC family
MRSL_RS09610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MRSL_RS09615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MRSL_RS09620	COG2814	Major facilitator Superfamily
MRSL_RS09625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MRSL_RS09630	COG0789	Transcriptional regulator
MRSL_RS09635	COG4221	oxidoreductase activity
MRSL_RS09645	COG0628	permease
MRSL_RS09655	COG0569	domain protein
MRSL_RS09655	COG0475	glutathione-regulated potassium exporter activity
MRSL_RS09660	COG2239	Acts as a magnesium transporter
MRSL_RS09665	COG0564	pseudouridine synthase activity
MRSL_RS09675	COG2357	RelA SpoT domain protein
MRSL_RS09690	COG2346	COG2346, Truncated hemoglobins
MRSL_RS09700	COG1164	Oligoendopeptidase f
MRSL_RS09715	COG1393	Belongs to the ArsC family
MRSL_RS09720	COG0180	Tryptophanyl-tRNA synthetase
MRSL_RS09725	COG2226	methyltransferase
MRSL_RS09730	COG4166	transmembrane transport
MRSL_RS09735	COG4608	Belongs to the ABC transporter superfamily
MRSL_RS09740	COG0444	Belongs to the ABC transporter superfamily
MRSL_RS09745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRSL_RS09750	COG0601	transmembrane transport
MRSL_RS09765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MRSL_RS09775	COG0542	response to heat
MRSL_RS09785	COG0561	phosphatase activity
MRSL_RS09790	COG0446	pyridine nucleotide-disulphide oxidoreductase
MRSL_RS09805	COG1074	ATP-dependent DNA helicase activity
MRSL_RS09825	COG0398	Pfam SNARE associated Golgi protein
MRSL_RS09830	COG0166	Belongs to the GPI family
MRSL_RS09835	COG0137	argininosuccinate synthase activity
MRSL_RS09870	COG1902	pentaerythritol trinitrate reductase activity
MRSL_RS09875	COG1098	S1 RNA binding domain
MRSL_RS09880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MRSL_RS09890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MRSL_RS09890	COG2111	Na H antiporter
MRSL_RS09895	COG2111	Na H antiporter
MRSL_RS09900	COG1006	Multisubunit Na H antiporter MnhC subunit
MRSL_RS09905	COG0651	ATP synthesis coupled electron transport
MRSL_RS09910	COG1863	multisubunit Na H antiporter MnhE subunit
MRSL_RS09915	COG2212	antiporter activity
MRSL_RS09920	COG1320	monovalent cation:proton antiporter activity
MRSL_RS09930	COG2050	protein possibly involved in aromatic compounds catabolism
MRSL_RS09935	COG2056	Na+-H+ antiporter family
MRSL_RS09940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MRSL_RS09945	COG1252	NADH dehydrogenase
MRSL_RS09955	COG1132	(ABC) transporter
MRSL_RS09965	COG1129	ABC transporter
MRSL_RS09995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MRSL_RS09995	COG3433	isochorismatase activity
MRSL_RS09995	COG2226	methyltransferase
MRSL_RS10000	COG1021	2,3-dihydroxybenzoate-AMP ligase
MRSL_RS10015	COG0316	Belongs to the HesB IscA family
MRSL_RS10020	COG4844	belongs to the
MRSL_RS10025	COG1252	NADH dehydrogenase
MRSL_RS10030	COG4837	Protein of unknown function (DUF1462)
MRSL_RS10035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MRSL_RS10040	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MRSL_RS10045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MRSL_RS10050	COG1696	Membrane protein involved in D-alanine export
MRSL_RS10055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MRSL_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRSL_RS10070	COG0647	UMP catabolic process
MRSL_RS10075	COG2445	Protein of unknown function DUF86
MRSL_RS10085	COG4470	Protein conserved in bacteria
MRSL_RS10090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MRSL_RS10095	COG0737	Belongs to the 5'-nucleotidase family
MRSL_RS10100	COG0730	response to heat
MRSL_RS10105	COG1801	Protein of unknown function DUF72
MRSL_RS10110	COG2070	2-Nitropropane dioxygenase
MRSL_RS10115	COG1253	flavin adenine dinucleotide binding
MRSL_RS10270	COG3942	CHAP domain
MRSL_RS10270	COG1388	LysM domain
MRSL_RS10295	COG0719	Fe-S assembly protein
MRSL_RS10300	COG0822	iron-sulfur transferase activity
MRSL_RS10310	COG0719	Fe-S assembly protein
MRSL_RS10315	COG0396	ATPase activity
MRSL_RS10335	COG1464	Belongs to the NlpA lipoprotein family
MRSL_RS10340	COG2011	ABC-type metal ion transport system permease component
MRSL_RS10345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MRSL_RS10355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MRSL_RS10360	COG0509	glycine decarboxylation via glycine cleavage system
MRSL_RS10365	COG1393	Belongs to the ArsC family
MRSL_RS10370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRSL_RS10380	COG0710	3-dehydroquinate dehydratase activity
MRSL_RS10385	COG1764	response to oxidative stress
MRSL_RS10395	COG0588	phosphoglycerate mutase activity
MRSL_RS10430	COG4195	phage-related replication protein
MRSL_RS10445	COG2259	Doxx family
MRSL_RS10450	COG0346	lactoylglutathione lyase activity
MRSL_RS10460	COG1611	Belongs to the LOG family
MRSL_RS10550	COG0557	exoribonuclease II activity
MRSL_RS10555	COG1647	Serine aminopeptidase, S33
MRSL_RS10560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MRSL_RS10570	COG0148	phosphopyruvate hydratase activity
MRSL_RS10575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MRSL_RS10580	COG0149	triose-phosphate isomerase activity
MRSL_RS10585	COG0126	phosphoglycerate kinase activity
MRSL_RS10605	COG1090	epimerase
MRSL_RS10610	COG0740	serine-type endopeptidase activity
MRSL_RS10615	COG1481	regulation of sporulation
MRSL_RS10620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MRSL_RS10625	COG1660	Displays ATPase and GTPase activities
MRSL_RS10630	COG0492	ferredoxin-NADP+ reductase activity
MRSL_RS10645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MRSL_RS10650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MRSL_RS10655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MRSL_RS10675	COG3942	CHAP domain
MRSL_RS10675	COG1388	LysM domain
MRSL_RS10685	COG0653	protein targeting
MRSL_RS10695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MRSL_RS10700	COG1040	competence protein
MRSL_RS10705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MRSL_RS10715	COG1739	Uncharacterized protein family UPF0029
MRSL_RS10720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MRSL_RS10725	COG2199	diguanylate cyclase activity
MRSL_RS10740	COG2195	Cleaves the N-terminal amino acid of tripeptides
MRSL_RS10750	COG1929	Belongs to the glycerate kinase type-1 family
MRSL_RS10770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MRSL_RS10780	COG4607	ABC-type enterochelin transport system periplasmic component
MRSL_RS10785	COG4604	ABC transporter, ATP-binding protein
MRSL_RS10790	COG4605	iron ion homeostasis
MRSL_RS10795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS10800	COG4607	ABC-type enterochelin transport system periplasmic component
MRSL_RS10805	COG4604	ABC transporter, ATP-binding protein
MRSL_RS10810	COG4605	iron ion homeostasis
MRSL_RS10815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS10820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRSL_RS10825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRSL_RS10830	COG1780	Probably involved in ribonucleotide reductase function
MRSL_RS10840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MRSL_RS10845	COG3104	oligopeptide transport
MRSL_RS10850	COG1597	lipid kinase activity
MRSL_RS10860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRSL_RS10865	COG3104	oligopeptide transport
MRSL_RS10870	COG1174	glycine betaine transport
MRSL_RS10880	COG0514	ATP-dependent DNA helicase (RecQ)
MRSL_RS10885	COG0488	(ABC) transporter
MRSL_RS10900	COG1368	sulfuric ester hydrolase activity
MRSL_RS10910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MRSL_RS10920	COG0512	Glutamine amidotransferase of anthranilate synthase
MRSL_RS10920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MRSL_RS10925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MRSL_RS10925	COG0512	Glutamine amidotransferase of anthranilate synthase
MRSL_RS10935	COG0720	synthase
MRSL_RS10950	COG0463	Glycosyl transferase, family 2
MRSL_RS10955	COG0656	L-ascorbic acid biosynthetic process
MRSL_RS10960	COG1253	flavin adenine dinucleotide binding
MRSL_RS10965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MRSL_RS10965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MRSL_RS10965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRSL_RS10970	COG1105	Belongs to the carbohydrate kinase PfkB family
MRSL_RS10975	COG1349	DNA-binding transcription factor activity
MRSL_RS10980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MRSL_RS11005	COG0471	metal ion transport
MRSL_RS11010	COG0039	L-malate dehydrogenase activity
MRSL_RS11025	COG0523	cobalamin synthesis protein
MRSL_RS11035	COG1968	undecaprenyl-diphosphatase activity
MRSL_RS11045	COG1671	Belongs to the UPF0178 family
MRSL_RS11050	COG1611	Belongs to the LOG family
MRSL_RS11075	COG2839	Protein conserved in bacteria
MRSL_RS11080	COG2814	Major facilitator Superfamily
MRSL_RS11085	COG0583	DNA-binding transcription factor activity
MRSL_RS11105	COG0217	transcriptional regulatory protein
MRSL_RS11130	COG1388	LysM domain
MRSL_RS11130	COG3942	CHAP domain
MRSL_RS11135	COG0306	phosphate transporter
MRSL_RS11140	COG1392	Phosphate transport regulator
MRSL_RS11145	COG0577	efflux transmembrane transporter activity
MRSL_RS11150	COG1136	(ABC) transporter
MRSL_RS11155	COG2205	protein histidine kinase activity
MRSL_RS11160	COG0745	RESPONSE REGULATOR receiver
MRSL_RS11165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRSL_RS11180	COG3949	Membrane
MRSL_RS11190	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MRSL_RS11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS11200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS11205	COG1120	ATPase activity
MRSL_RS11210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MRSL_RS11220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MRSL_RS11225	COG0463	Glycosyl transferase, family 2
MRSL_RS11225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS11230	COG0438	transferase activity, transferring glycosyl groups
MRSL_RS11235	COG1132	(ABC) transporter
MRSL_RS11240	COG1686	Belongs to the peptidase S11 family
MRSL_RS11245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MRSL_RS11250	COG1215	transferase activity, transferring glycosyl groups
MRSL_RS11255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS11265	COG1682	transport, permease protein
MRSL_RS11270	COG1134	teichoic acid transport
MRSL_RS11285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MRSL_RS11295	COG1321	iron dependent repressor
MRSL_RS11300	COG1121	(ABC) transporter
MRSL_RS11305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MRSL_RS11310	COG0803	Belongs to the bacterial solute-binding protein 9 family
MRSL_RS11320	COG1320	monovalent cation:proton antiporter activity
MRSL_RS11325	COG2212	antiporter activity
MRSL_RS11330	COG1863	multisubunit Na H antiporter MnhE subunit
MRSL_RS11335	COG0651	ATP synthesis coupled electron transport
MRSL_RS11340	COG1006	Multisubunit Na H antiporter MnhC subunit
MRSL_RS11345	COG2111	Na H antiporter
MRSL_RS11350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MRSL_RS11350	COG2111	Na H antiporter
MRSL_RS11355	COG4974	Belongs to the 'phage' integrase family
MRSL_RS11385	COG0596	Alpha beta hydrolase
MRSL_RS11410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRSL_RS11415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MRSL_RS11435	COG0018	arginyl-trna synthetase
MRSL_RS11460	COG1064	alcohol dehydrogenase
MRSL_RS11470	COG1078	dGTPase activity
MRSL_RS11480	COG0655	NAD(P)H dehydrogenase (quinone) activity
MRSL_RS11485	COG0667	Aldo Keto reductase
MRSL_RS11495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRSL_RS11500	COG4844	belongs to the
MRSL_RS11520	COG0095	Lipoate-protein ligase
MRSL_RS11555	COG0531	amino acid
MRSL_RS11560	COG2363	Small membrane protein
MRSL_RS11570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MRSL_RS11605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MRSL_RS11610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MRSL_RS11620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MRSL_RS11630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MRSL_RS11655	COG0561	phosphatase activity
MRSL_RS11665	COG1428	Deoxynucleoside kinase
MRSL_RS11670	COG1428	Deoxynucleoside kinase
MRSL_RS11690	COG0531	amino acid
MRSL_RS11695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MRSL_RS11705	COG1279	arginine transmembrane transporter activity
MRSL_RS11730	COG1473	amidohydrolase
MRSL_RS11735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MRSL_RS11750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MRSL_RS11760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MRSL_RS11765	COG0085	RNA polymerase activity
MRSL_RS11770	COG2813	Specifically methylates the guanine in position
MRSL_RS11775	COG0222	ribosome binding
MRSL_RS11780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MRSL_RS11785	COG0081	regulation of translation
MRSL_RS11795	COG0250	Participates in transcription elongation, termination and antitermination
MRSL_RS11800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MRSL_RS11805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MRSL_RS11815	COG3688	RNA-binding protein containing a PIN domain
MRSL_RS11820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MRSL_RS11825	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MRSL_RS11830	COG0215	cysteine-tRNA ligase activity
MRSL_RS11835	COG1045	serine acetyltransferase
MRSL_RS11840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRSL_RS11845	COG4956	integral membrane protein (PIN domain superfamily)
MRSL_RS11850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MRSL_RS11855	COG0542	response to heat
MRSL_RS11860	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MRSL_RS11865	COG3880	PFAM UvrB UvrC protein
MRSL_RS11870	COG4463	regulation of RNA biosynthetic process
MRSL_RS11875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MRSL_RS11880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MRSL_RS11885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MRSL_RS11890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MRSL_RS11975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MRSL_RS11980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MRSL_RS11985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MRSL_RS11995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MRSL_RS12005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRSL_RS12020	COG1098	S1 RNA binding domain
MRSL_RS12030	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MRSL_RS12035	COG3956	TIGRFAM MazG family protein
MRSL_RS12040	COG2244	polysaccharide biosynthetic process
MRSL_RS12045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MRSL_RS12050	COG0193	aminoacyl-tRNA hydrolase activity
MRSL_RS12060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MRSL_RS12065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MRSL_RS12075	COG0251	oxidation-reduction process
MRSL_RS12080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MRSL_RS12085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MRSL_RS12090	COG4466	Protein conserved in bacteria
MRSL_RS12095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MRSL_RS12100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MRSL_RS12105	COG0084	hydrolase, TatD family'
MRSL_RS12110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRSL_RS12110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRSL_RS12115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MRSL_RS12125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MRSL_RS12135	COG1774	PSP1 C-terminal conserved region
MRSL_RS12140	COG0470	DNA polymerase III
MRSL_RS12145	COG3870	Protein conserved in bacteria
MRSL_RS12150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MRSL_RS12155	COG1982	Orn Lys Arg decarboxylase major
MRSL_RS12190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MRSL_RS12200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MRSL_RS12215	COG2188	Transcriptional regulator
MRSL_RS12220	COG0366	Alpha amylase catalytic
MRSL_RS12225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRSL_RS12225	COG1263	PTS System
MRSL_RS12235	COG0493	'glutamate synthase
MRSL_RS12240	COG0069	glutamate synthase activity
MRSL_RS12240	COG0070	glutamate synthase
MRSL_RS12240	COG0067	glutamate synthase
MRSL_RS12245	COG0583	DNA-binding transcription factor activity
MRSL_RS12275	COG1464	Belongs to the NlpA lipoprotein family
MRSL_RS12280	COG2011	ABC-type metal ion transport system permease component
MRSL_RS12285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MRSL_RS12290	COG1132	(ABC) transporter
MRSL_RS12300	COG0626	cystathionine gamma-synthase activity
MRSL_RS12305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MRSL_RS12315	COG0733	neurotransmitter:sodium symporter activity
MRSL_RS12335	COG5609	conserved protein (DUF2294)
MRSL_RS12340	COG3002	Belongs to the UPF0753 family
MRSL_RS12345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MRSL_RS12355	COG0523	cobalamin synthesis protein
MRSL_RS12375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MRSL_RS12375	COG0519	Catalyzes the synthesis of GMP from XMP
MRSL_RS12380	COG0516	GMP reductase activity
MRSL_RS12380	COG0517	IMP dehydrogenase activity
MRSL_RS12385	COG2233	PERMEase
MRSL_RS12390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MRSL_RS12410	COG1823	symporter activity
MRSL_RS12415	COG0778	Nitroreductase
MRSL_RS12425	COG0450	alkyl hydroperoxide reductase
MRSL_RS12430	COG3634	alkyl hydroperoxide reductase activity
MRSL_RS12445	COG0588	phosphoglycerate mutase activity
MRSL_RS12490	COG5484	DNA packaging
MRSL_RS12490	COG3728	DNA packaging
MRSL_RS12565	COG0582	viral genome integration into host DNA
MRSL_RS12570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MRSL_RS12580	COG0360	Binds together with S18 to 16S ribosomal RNA
MRSL_RS12595	COG0012	GTP binding
MRSL_RS12600	COG4481	Protein conserved in bacteria
MRSL_RS12605	COG0668	transmembrane transport
MRSL_RS12610	COG1475	DNA binding
MRSL_RS12615	COG0626	cystathionine gamma-synthase activity
MRSL_RS12620	COG0626	cystathionine gamma-synthase activity
MRSL_RS12625	COG0646	methionine synthase
MRSL_RS12625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MRSL_RS12630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MRSL_RS12655	COG0577	efflux transmembrane transporter activity
MRSL_RS12660	COG1136	(ABC) transporter
MRSL_RS12680	COG2205	protein histidine kinase activity
MRSL_RS12695	COG0745	RESPONSE REGULATOR receiver
MRSL_RS12720	COG3878	Protein conserved in bacteria
MRSL_RS12725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MRSL_RS12730	COG2271	Major facilitator Superfamily
MRSL_RS12755	COG1136	(ABC) transporter
MRSL_RS12760	COG0577	efflux transmembrane transporter activity
MRSL_RS12770	COG1396	sequence-specific DNA binding
MRSL_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
MRSL_RS12795	COG1063	alcohol dehydrogenase
MRSL_RS12815	COG1475	DNA binding
MRSL_RS12825	COG0445	tRNA wobble uridine modification
MRSL_RS12830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MRSL_RS12835	COG0594	ribonuclease P activity