locus-tag	class	description
LE164_RS00010	COG1309	transcriptional regulator
LE164_RS00020	COG1131	(ABC) transporter
LE164_RS00030	COG1131	(ABC) transporter
LE164_RS00045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LE164_RS00050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LE164_RS00055	COG0101	tRNA pseudouridine synthase activity
LE164_RS00065	COG1122	ATPase activity
LE164_RS00075	COG0203	ribosomal protein L17
LE164_RS00080	COG0202	RNA polymerase activity
LE164_RS00090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LE164_RS00095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LE164_RS00100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LE164_RS00105	COG0563	adenylate kinase activity
LE164_RS00110	COG0201	protein transport
LE164_RS00120	COG1841	ribosomal large subunit assembly
LE164_RS00125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LE164_RS00130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LE164_RS00135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LE164_RS00140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LE164_RS00155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LE164_RS00165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LE164_RS00175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LE164_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LE164_RS00190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LE164_RS00195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LE164_RS00200	COG0089	rRNA binding
LE164_RS00205	COG0088	Forms part of the polypeptide exit tunnel
LE164_RS00210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LE164_RS00225	COG2252	PERMEase
LE164_RS00255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LE164_RS00260	COG2348	transferase activity, transferring amino-acyl groups
LE164_RS00285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LE164_RS00290	COG0746	molybdenum cofactor guanylyltransferase activity
LE164_RS00320	COG0521	Mo-molybdopterin cofactor biosynthetic process
LE164_RS00325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LE164_RS00330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LE164_RS00335	COG4149	molybdate abc transporter
LE164_RS00340	COG0725	ABC transporter, periplasmic molybdate-binding protein
LE164_RS00345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LE164_RS00355	COG1268	BioY protein
LE164_RS00365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LE164_RS00370	COG1960	acyl-CoA dehydrogenase activity
LE164_RS00400	COG3942	CHAP domain
LE164_RS00405	COG1757	Na H antiporter
LE164_RS00420	COG3942	CHAP domain
LE164_RS00425	COG2076	Multidrug Resistance protein
LE164_RS00430	COG2076	Multidrug Resistance protein
LE164_RS00435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LE164_RS00460	COG1316	TRANSCRIPTIONal
LE164_RS00470	COG1349	DNA-binding transcription factor activity
LE164_RS00480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LE164_RS00485	COG1263	PTS System
LE164_RS00485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS00490	COG1737	Transcriptional regulator
LE164_RS00495	COG1113	amino acid transport
LE164_RS00515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LE164_RS00525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS00525	COG1263	PTS System
LE164_RS00530	COG1737	Transcriptional regulator
LE164_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS00555	COG1473	amidohydrolase
LE164_RS00560	COG1266	CAAX protease self-immunity
LE164_RS00565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LE164_RS00570	COG2258	MOSC domain
LE164_RS00575	COG2017	converts alpha-aldose to the beta-anomer
LE164_RS00585	COG2094	Belongs to the DNA glycosylase MPG family
LE164_RS00590	COG1304	FMN binding
LE164_RS00595	COG0598	Magnesium transport protein CorA
LE164_RS00620	COG2814	Major facilitator Superfamily
LE164_RS00625	COG1566	PFAM secretion protein HlyD family protein
LE164_RS00635	COG2814	Major facilitator Superfamily
LE164_RS00685	COG0579	oxidoreductase
LE164_RS00690	COG0297	glycogen (starch) synthase activity
LE164_RS00695	COG1620	l-lactate permease
LE164_RS00700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS00710	COG0456	acetyltransferase
LE164_RS00715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LE164_RS00720	COG0805	protein transport
LE164_RS00725	COG0672	)-iron permease
LE164_RS00730	COG2837	iron assimilation
LE164_RS00735	COG2822	iron ion transport
LE164_RS00740	COG0604	alcohol dehydrogenase
LE164_RS00755	COG0492	ferredoxin-NADP+ reductase activity
LE164_RS00760	COG2314	TM2 domain
LE164_RS00780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LE164_RS00825	COG0583	DNA-binding transcription factor activity
LE164_RS00830	COG2814	Major facilitator Superfamily
LE164_RS00855	COG0488	(ABC) transporter
LE164_RS00870	COG2962	Rard protein
LE164_RS00875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LE164_RS00880	COG4716	Myosin-crossreactive antigen
LE164_RS00890	COG4413	Urea transporter
LE164_RS00895	COG0831	urea catabolic process
LE164_RS00905	COG0804	urea catabolic process
LE164_RS00910	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LE164_RS00925	COG0829	nickel cation binding
LE164_RS00935	COG0601	transmembrane transport
LE164_RS00945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LE164_RS00950	COG1124	(ABC) transporter
LE164_RS00960	COG0534	Mate efflux family protein
LE164_RS00985	COG1263	PTS System
LE164_RS00985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS01025	COG1846	Transcriptional regulator
LE164_RS01030	COG2223	nitrite transmembrane transporter activity
LE164_RS01040	COG4585	Histidine kinase
LE164_RS01050	COG2181	nitrate reductase activity
LE164_RS01060	COG1140	nitrate reductase beta subunit
LE164_RS01065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LE164_RS01075	COG2146	nitrite reductase [NAD(P)H] activity
LE164_RS01080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LE164_RS01090	COG2116	formate transmembrane transporter activity
LE164_RS01100	COG1131	(ABC) transporter
LE164_RS01140	COG1126	abc transporter atp-binding protein
LE164_RS01145	COG0765	amino acid transport
LE164_RS01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LE164_RS01155	COG2814	Major facilitator Superfamily
LE164_RS01165	COG0588	phosphoglycerate mutase activity
LE164_RS01170	COG0741	lytic transglycosylase activity
LE164_RS01175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LE164_RS01185	COG1929	Belongs to the glycerate kinase type-1 family
LE164_RS01195	COG2814	Major facilitator Superfamily
LE164_RS01215	COG1113	amino acid transport
LE164_RS01220	COG0025	NhaP-type Na H and K H
LE164_RS01230	COG0531	amino acid
LE164_RS01240	COG0706	membrane insertase activity
LE164_RS01255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LE164_RS01265	COG3275	phosphorelay sensor kinase activity
LE164_RS01270	COG3279	Response regulator of the LytR AlgR family
LE164_RS01275	COG1380	Effector of murein hydrolase LrgA
LE164_RS01280	COG1346	cytolysis
LE164_RS01320	COG1174	glycine betaine transport
LE164_RS01340	COG1063	alcohol dehydrogenase
LE164_RS01345	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LE164_RS01350	COG2272	Belongs to the type-B carboxylesterase lipase family
LE164_RS01355	COG2814	Major facilitator Superfamily
LE164_RS01365	COG0745	RESPONSE REGULATOR receiver
LE164_RS01370	COG2205	protein histidine kinase activity
LE164_RS01375	COG0390	transport system, permease component
LE164_RS01380	COG4619	ABC transporter
LE164_RS01395	COG0069	glutamate synthase activity
LE164_RS01400	COG0737	Belongs to the 5'-nucleotidase family
LE164_RS01415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LE164_RS01420	COG3639	organic phosphonate transmembrane transporter activity
LE164_RS01440	COG1363	Peptidase, m42
LE164_RS01445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LE164_RS01455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LE164_RS01460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LE164_RS01465	COG4221	oxidoreductase activity
LE164_RS01480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LE164_RS01485	COG0438	transferase activity, transferring glycosyl groups
LE164_RS01490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LE164_RS01505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LE164_RS01510	COG2610	gluconate transmembrane transporter activity
LE164_RS01515	COG1070	Carbohydrate kinase
LE164_RS01520	COG1802	Transcriptional regulator
LE164_RS01535	COG2357	RelA SpoT domain protein
LE164_RS01540	COG4876	unkown
LE164_RS01555	COG2271	Major facilitator Superfamily
LE164_RS01575	COG2022	thiamine diphosphate biosynthetic process
LE164_RS01585	COG0586	Pfam SNARE associated Golgi protein
LE164_RS01590	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LE164_RS01600	COG3949	Membrane
LE164_RS01605	COG0400	carboxylic ester hydrolase activity
LE164_RS01610	COG0346	lactoylglutathione lyase activity
LE164_RS01615	COG0346	lactoylglutathione lyase activity
LE164_RS01620	COG1846	Transcriptional regulator
LE164_RS01640	COG2388	GCN5-related N-acetyl-transferase
LE164_RS01645	COG2514	catechol 2,3-dioxygenase activity
LE164_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
LE164_RS01660	COG0778	Nitroreductase
LE164_RS01665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LE164_RS01675	COG0561	phosphatase activity
LE164_RS01690	COG3764	Sortase (surface protein transpeptidase)
LE164_RS01705	COG1760	l-serine dehydratase
LE164_RS01710	COG1760	l-serine dehydratase
LE164_RS01720	COG1070	Carbohydrate kinase
LE164_RS01745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LE164_RS01755	COG0657	acetylesterase activity
LE164_RS01760	COG0039	L-malate dehydrogenase activity
LE164_RS01765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LE164_RS01780	COG0028	Belongs to the TPP enzyme family
LE164_RS01785	COG1346	cytolysis
LE164_RS01790	COG1380	Effector of murein hydrolase LrgA
LE164_RS01795	COG0583	DNA-binding transcription factor activity
LE164_RS01805	COG1388	LysM domain
LE164_RS01805	COG3942	CHAP domain
LE164_RS01820	COG3425	synthase
LE164_RS01830	COG1131	(ABC) transporter
LE164_RS01855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LE164_RS01860	COG0598	Magnesium transport protein CorA
LE164_RS01870	COG2409	Drug exporters of the RND superfamily
LE164_RS01880	COG1012	belongs to the aldehyde dehydrogenase family
LE164_RS01885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LE164_RS01890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS01895	COG0110	maltose O-acetyltransferase activity
LE164_RS01905	COG2217	Heavy metal translocating P-type atpase
LE164_RS01910	COG2608	mercury ion transmembrane transporter activity
LE164_RS01920	COG0436	Aminotransferase
LE164_RS01940	COG3189	MarR family transcriptional regulator
LE164_RS01950	COG1113	amino acid transport
LE164_RS01960	COG2814	Major facilitator Superfamily
LE164_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS02010	COG0596	Alpha beta hydrolase
LE164_RS02015	COG3001	Fructosamine kinase
LE164_RS02020	COG0167	dihydroorotate dehydrogenase activity
LE164_RS02040	COG1620	l-lactate permease
LE164_RS02045	COG3527	Alpha-acetolactate decarboxylase
LE164_RS02050	COG0028	Belongs to the TPP enzyme family
LE164_RS02055	COG0583	DNA-binding transcription factor activity
LE164_RS02060	COG0531	amino acid
LE164_RS02070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS02070	COG1215	transferase activity, transferring glycosyl groups
LE164_RS02080	COG0463	Glycosyl transferase, family 2
LE164_RS02090	COG1464	Belongs to the NlpA lipoprotein family
LE164_RS02105	COG3588	fructose-bisphosphate aldolase
LE164_RS02120	COG0583	DNA-binding transcription factor activity
LE164_RS02130	COG2723	6-phospho-beta-galactosidase activity
LE164_RS02135	COG1263	PTS System
LE164_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS02135	COG2190	(PTS) system
LE164_RS02140	COG2188	Transcriptional regulator
LE164_RS02150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LE164_RS02155	COG0574	Belongs to the PEP-utilizing enzyme family
LE164_RS02155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LE164_RS02160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LE164_RS02175	COG1473	amidohydrolase
LE164_RS02180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LE164_RS02185	COG1012	belongs to the aldehyde dehydrogenase family
LE164_RS02190	COG1510	regulation of RNA biosynthetic process
LE164_RS02195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LE164_RS02200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LE164_RS02210	COG0602	queuosine metabolic process
LE164_RS02215	COG1328	CTP reductase activity
LE164_RS02230	COG0529	Catalyzes the synthesis of activated sulfate
LE164_RS02235	COG2046	Belongs to the sulfate adenylyltransferase family
LE164_RS02240	COG0730	response to heat
LE164_RS02255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LE164_RS02260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LE164_RS02265	COG0175	sulfate reduction
LE164_RS02275	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LE164_RS02275	COG3266	domain, Protein
LE164_RS02275	COG4932	domain protein
LE164_RS02275	COG3266	domain, Protein
LE164_RS02275	COG4932	domain protein
LE164_RS02275	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LE164_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS02315	COG1136	(ABC) transporter
LE164_RS02320	COG2205	protein histidine kinase activity
LE164_RS02335	COG1785	Belongs to the alkaline phosphatase family
LE164_RS02340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LE164_RS02345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LE164_RS02350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LE164_RS02360	COG0297	glycogen (starch) synthase activity
LE164_RS02385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LE164_RS02425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LE164_RS02430	COG4195	phage-related replication protein
LE164_RS02435	COG2843	Capsule synthesis protein
LE164_RS02445	COG2235	arginine
LE164_RS02460	COG2226	methyltransferase
LE164_RS02470	COG0640	Transcriptional regulator
LE164_RS02515	COG1705	Flagellar rod assembly protein muramidase FlgJ
LE164_RS02515	COG3942	CHAP domain
LE164_RS02545	COG1476	TRANSCRIPTIONal
LE164_RS02555	COG1122	ATPase activity
LE164_RS02565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LE164_RS02580	COG3386	PFAM SMP-30 Gluconolaconase
LE164_RS02585	COG1054	Belongs to the UPF0176 family
LE164_RS02590	COG3037	sugar-specific permease SgaT UlaA
LE164_RS02600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS02605	COG3711	transcriptional antiterminator
LE164_RS02605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS02610	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LE164_RS02630	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LE164_RS02635	COG1266	CAAX protease self-immunity
LE164_RS02665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LE164_RS02675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LE164_RS02680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LE164_RS02695	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LE164_RS02700	COG0363	glucosamine-6-phosphate deaminase activity
LE164_RS02710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LE164_RS02735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LE164_RS02785	COG0531	amino acid
LE164_RS02795	COG0706	membrane insertase activity
LE164_RS02820	COG1482	cell wall glycoprotein biosynthetic process
LE164_RS02825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LE164_RS02825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LE164_RS02825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS02830	COG3711	transcriptional antiterminator
LE164_RS02830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS02850	COG1695	Transcriptional regulator
LE164_RS02860	COG0022	dehydrogenase e1 component
LE164_RS02865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LE164_RS02870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LE164_RS02880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LE164_RS02895	COG0431	NADPH-dependent FMN reductase
LE164_RS02895	COG3976	FMN-binding domain protein
LE164_RS02895	COG1053	succinate dehydrogenase
LE164_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS02925	COG1263	PTS System
LE164_RS02925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS02925	COG2190	(PTS) system
LE164_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS02955	COG2814	Major facilitator Superfamily
LE164_RS02965	COG1288	antiporter activity
LE164_RS02970	COG2353	YceI-like domain
LE164_RS02980	COG1131	(ABC) transporter
LE164_RS02995	COG3961	Belongs to the TPP enzyme family
LE164_RS03000	COG1124	(ABC) transporter
LE164_RS03005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LE164_RS03015	COG0601	transmembrane transport
LE164_RS03020	COG0747	negative chemotaxis
LE164_RS03025	COG2264	protein methyltransferase activity
LE164_RS03050	COG1131	(ABC) transporter
LE164_RS03065	COG2814	Major facilitator Superfamily
LE164_RS03085	COG1233	COG1233 Phytoene dehydrogenase and related
LE164_RS03095	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LE164_RS03100	COG2311	Membrane
LE164_RS03115	COG1278	Cold shock
LE164_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS03130	COG1131	(ABC) transporter
LE164_RS03165	COG2409	Drug exporters of the RND superfamily
LE164_RS03165	COG1033	growth of symbiont in host cell
LE164_RS03205	COG0657	acetylesterase activity
LE164_RS03210	COG0505	Belongs to the CarA family
LE164_RS03215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LE164_RS03215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LE164_RS03220	COG0531	amino acid
LE164_RS03225	COG0693	protein deglycase activity
LE164_RS03240	COG1124	(ABC) transporter
LE164_RS03245	COG0444	Belongs to the ABC transporter superfamily
LE164_RS03255	COG0601	transmembrane transport
LE164_RS03270	COG2814	Major facilitator Superfamily
LE164_RS03275	COG0561	phosphatase activity
LE164_RS03280	COG0464	growth
LE164_RS03295	COG1114	Component of the transport system for branched-chain amino acids
LE164_RS03305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LE164_RS03320	COG2610	gluconate transmembrane transporter activity
LE164_RS03325	COG4948	Mandelate Racemase Muconate Lactonizing
LE164_RS03330	COG0800	Aldolase
LE164_RS03340	COG1414	Transcriptional regulator
LE164_RS03345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LE164_RS03350	COG1177	transmembrane transport
LE164_RS03355	COG1840	ABC-type Fe3 transport system, periplasmic component
LE164_RS03360	COG3842	ATPase activity
LE164_RS03365	COG0583	DNA-binding transcription factor activity
LE164_RS03405	COG5002	protein histidine kinase activity
LE164_RS03415	COG1349	DNA-binding transcription factor activity
LE164_RS03420	COG0534	Mate efflux family protein
LE164_RS03430	COG0395	ABC-type sugar transport system, permease component
LE164_RS03440	COG4209	transmembrane transport
LE164_RS03445	COG3842	ATPase activity
LE164_RS03455	COG1846	Transcriptional regulator
LE164_RS03465	COG2808	Putative FMN-binding domain
LE164_RS03470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LE164_RS03480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS03485	COG3942	CHAP domain
LE164_RS03485	COG1705	Flagellar rod assembly protein muramidase FlgJ
LE164_RS03495	COG4509	Sortase family
LE164_RS03535	COG1129	ABC transporter
LE164_RS03560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LE164_RS03565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LE164_RS03570	COG2205	protein histidine kinase activity
LE164_RS03575	COG0745	RESPONSE REGULATOR receiver
LE164_RS03585	COG3716	PTS system mannose fructose sorbose family IID component
LE164_RS03590	COG3715	PTS system
LE164_RS03595	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS03600	COG3684	Belongs to the aldolase LacD family
LE164_RS03605	COG2222	sugar isomerase
LE164_RS03610	COG2188	Transcriptional regulator
LE164_RS03685	COG1332	CRISPR-associated RAMP protein, Csm5 family
LE164_RS03690	COG1567	CRISPR-associated RAMP protein, Csm4 family
LE164_RS03695	COG1337	RAMP superfamily
LE164_RS03700	COG1421	Csm2 Type III-A
LE164_RS03705	COG1353	crispr-associated protein
LE164_RS03710	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LE164_RS03715	COG1518	maintenance of DNA repeat elements
LE164_RS03720	COG1131	(ABC) transporter
LE164_RS03730	COG0745	RESPONSE REGULATOR receiver
LE164_RS03775	COG1129	ABC transporter
LE164_RS03795	COG1073	alpha beta
LE164_RS03815	COG1522	sequence-specific DNA binding
LE164_RS03830	COG0076	glutamate decarboxylase activity
LE164_RS03840	COG0210	DNA helicase
LE164_RS03845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LE164_RS03855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LE164_RS03860	COG0732	type I restriction modification DNA specificity domain
LE164_RS03865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LE164_RS03945	COG0640	Transcriptional regulator
LE164_RS03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LE164_RS03980	COG0730	response to heat
LE164_RS03985	COG1937	Protein conserved in bacteria
LE164_RS03990	COG2210	Belongs to the sulfur carrier protein TusA family
LE164_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LE164_RS04000	COG1388	LysM domain
LE164_RS04005	COG2217	Heavy metal translocating P-type atpase
LE164_RS04010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LE164_RS04015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LE164_RS04050	COG4863	YycH protein
LE164_RS04055	COG5002	protein histidine kinase activity
LE164_RS04060	COG0745	RESPONSE REGULATOR receiver
LE164_RS04075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LE164_RS04080	COG0305	Participates in initiation and elongation during chromosome replication
LE164_RS04085	COG0359	binds to the 23S rRNA
LE164_RS04090	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LE164_RS04100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LE164_RS04110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LE164_RS04120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LE164_RS04125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LE164_RS04130	COG0187	DNA topoisomerase II activity
LE164_RS04135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LE164_RS04140	COG2501	S4 domain
LE164_RS04145	COG0592	DNA-directed DNA polymerase activity
LE164_RS04150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LE164_RS04160	COG0594	ribonuclease P activity
LE164_RS04165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LE164_RS04170	COG0445	tRNA wobble uridine modification
LE164_RS04180	COG1475	DNA binding
LE164_RS04200	COG1063	alcohol dehydrogenase
LE164_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
LE164_RS04225	COG1396	sequence-specific DNA binding
LE164_RS04235	COG0577	efflux transmembrane transporter activity
LE164_RS04240	COG1136	(ABC) transporter
LE164_RS04255	COG2271	Major facilitator Superfamily
LE164_RS04260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LE164_RS04265	COG3878	Protein conserved in bacteria
LE164_RS04290	COG0745	RESPONSE REGULATOR receiver
LE164_RS04305	COG2205	protein histidine kinase activity
LE164_RS04325	COG1136	(ABC) transporter
LE164_RS04330	COG0577	efflux transmembrane transporter activity
LE164_RS04355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LE164_RS04360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LE164_RS04360	COG0646	methionine synthase
LE164_RS04365	COG0626	cystathionine gamma-synthase activity
LE164_RS04370	COG0626	cystathionine gamma-synthase activity
LE164_RS04375	COG1475	DNA binding
LE164_RS04380	COG0668	transmembrane transport
LE164_RS04385	COG4481	Protein conserved in bacteria
LE164_RS04390	COG0012	GTP binding
LE164_RS04405	COG0360	Binds together with S18 to 16S ribosomal RNA
LE164_RS04415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LE164_RS04450	COG0588	phosphoglycerate mutase activity
LE164_RS04465	COG3634	alkyl hydroperoxide reductase activity
LE164_RS04470	COG0450	alkyl hydroperoxide reductase
LE164_RS04480	COG0778	Nitroreductase
LE164_RS04485	COG1823	symporter activity
LE164_RS04505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LE164_RS04510	COG2233	PERMEase
LE164_RS04515	COG0517	IMP dehydrogenase activity
LE164_RS04515	COG0516	GMP reductase activity
LE164_RS04520	COG0519	Catalyzes the synthesis of GMP from XMP
LE164_RS04520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LE164_RS04540	COG0523	cobalamin synthesis protein
LE164_RS04545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LE164_RS04550	COG3002	Belongs to the UPF0753 family
LE164_RS04555	COG5609	conserved protein (DUF2294)
LE164_RS04575	COG0733	neurotransmitter:sodium symporter activity
LE164_RS04585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LE164_RS04590	COG0626	cystathionine gamma-synthase activity
LE164_RS04595	COG2375	cellular response to nickel ion
LE164_RS04595	COG1132	(ABC) transporter
LE164_RS04600	COG1132	(ABC) transporter
LE164_RS04605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LE164_RS04610	COG2011	ABC-type metal ion transport system permease component
LE164_RS04615	COG1464	Belongs to the NlpA lipoprotein family
LE164_RS04645	COG0583	DNA-binding transcription factor activity
LE164_RS04650	COG0069	glutamate synthase activity
LE164_RS04650	COG0067	glutamate synthase
LE164_RS04650	COG0070	glutamate synthase
LE164_RS04655	COG0493	'glutamate synthase
LE164_RS04665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS04665	COG1263	PTS System
LE164_RS04670	COG0366	Alpha amylase catalytic
LE164_RS04675	COG2188	Transcriptional regulator
LE164_RS04690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LE164_RS04700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LE164_RS04735	COG1982	Orn Lys Arg decarboxylase major
LE164_RS04740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LE164_RS04745	COG3870	Protein conserved in bacteria
LE164_RS04750	COG0470	DNA polymerase III
LE164_RS04755	COG1774	PSP1 C-terminal conserved region
LE164_RS04765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LE164_RS04775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LE164_RS04780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LE164_RS04780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LE164_RS04785	COG0084	hydrolase, TatD family'
LE164_RS04790	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LE164_RS04795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LE164_RS04800	COG4466	Protein conserved in bacteria
LE164_RS04805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LE164_RS04810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LE164_RS04815	COG0251	oxidation-reduction process
LE164_RS04825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LE164_RS04830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LE164_RS04840	COG0193	aminoacyl-tRNA hydrolase activity
LE164_RS04845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LE164_RS04850	COG2244	polysaccharide biosynthetic process
LE164_RS04855	COG3956	TIGRFAM MazG family protein
LE164_RS04860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LE164_RS04870	COG1098	S1 RNA binding domain
LE164_RS04885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LE164_RS04895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LE164_RS04905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LE164_RS04910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LE164_RS04915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LE164_RS04995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LE164_RS05000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LE164_RS05005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LE164_RS05010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LE164_RS05015	COG4463	regulation of RNA biosynthetic process
LE164_RS05020	COG3880	PFAM UvrB UvrC protein
LE164_RS05025	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LE164_RS05030	COG0542	response to heat
LE164_RS05035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LE164_RS05040	COG4956	integral membrane protein (PIN domain superfamily)
LE164_RS05045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LE164_RS05050	COG1045	serine acetyltransferase
LE164_RS05055	COG0215	cysteine-tRNA ligase activity
LE164_RS05060	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LE164_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LE164_RS05070	COG3688	RNA-binding protein containing a PIN domain
LE164_RS05080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LE164_RS05085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LE164_RS05090	COG0250	Participates in transcription elongation, termination and antitermination
LE164_RS05100	COG0081	regulation of translation
LE164_RS05105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LE164_RS05110	COG0222	ribosome binding
LE164_RS05115	COG2813	Specifically methylates the guanine in position
LE164_RS05120	COG0085	RNA polymerase activity
LE164_RS05125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LE164_RS05135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LE164_RS05150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LE164_RS05155	COG1473	amidohydrolase
LE164_RS05190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LE164_RS05195	COG0531	amino acid
LE164_RS05215	COG1428	Deoxynucleoside kinase
LE164_RS05220	COG1428	Deoxynucleoside kinase
LE164_RS05230	COG0561	phosphatase activity
LE164_RS05255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS05265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LE164_RS05275	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LE164_RS05280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LE164_RS05315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LE164_RS05325	COG2363	Small membrane protein
LE164_RS05355	COG3253	May function as heme-dependent peroxidase
LE164_RS05365	COG0095	Lipoate-protein ligase
LE164_RS05385	COG4844	belongs to the
LE164_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LE164_RS05400	COG0667	Aldo Keto reductase
LE164_RS05405	COG0655	NAD(P)H dehydrogenase (quinone) activity
LE164_RS05415	COG1078	dGTPase activity
LE164_RS05425	COG1064	alcohol dehydrogenase
LE164_RS05450	COG0018	arginyl-trna synthetase
LE164_RS05470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LE164_RS05475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS05500	COG0596	Alpha beta hydrolase
LE164_RS05530	COG4974	Belongs to the 'phage' integrase family
LE164_RS05535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LE164_RS05535	COG2111	Na H antiporter
LE164_RS05540	COG2111	Na H antiporter
LE164_RS05545	COG1006	Multisubunit Na H antiporter MnhC subunit
LE164_RS05550	COG0651	ATP synthesis coupled electron transport
LE164_RS05555	COG1863	multisubunit Na H antiporter MnhE subunit
LE164_RS05560	COG2212	antiporter activity
LE164_RS05565	COG1320	monovalent cation:proton antiporter activity
LE164_RS05575	COG0803	Belongs to the bacterial solute-binding protein 9 family
LE164_RS05580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LE164_RS05585	COG1121	(ABC) transporter
LE164_RS05590	COG1321	iron dependent repressor
LE164_RS05600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LE164_RS05615	COG1134	teichoic acid transport
LE164_RS05620	COG1682	transport, permease protein
LE164_RS05625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS05630	COG1215	transferase activity, transferring glycosyl groups
LE164_RS05635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LE164_RS05640	COG1686	Belongs to the peptidase S11 family
LE164_RS05645	COG1132	(ABC) transporter
LE164_RS05650	COG0438	transferase activity, transferring glycosyl groups
LE164_RS05655	COG0463	Glycosyl transferase, family 2
LE164_RS05655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LE164_RS05660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LE164_RS05670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LE164_RS05675	COG1120	ATPase activity
LE164_RS05680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS05685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS05690	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LE164_RS05700	COG3949	Membrane
LE164_RS05705	COG0657	acetylesterase activity
LE164_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LE164_RS05720	COG0745	RESPONSE REGULATOR receiver
LE164_RS05725	COG2205	protein histidine kinase activity
LE164_RS05730	COG1136	(ABC) transporter
LE164_RS05735	COG0577	efflux transmembrane transporter activity
LE164_RS05740	COG1392	Phosphate transport regulator
LE164_RS05745	COG0306	phosphate transporter
LE164_RS05750	COG1388	LysM domain
LE164_RS05750	COG3942	CHAP domain
LE164_RS05775	COG0217	transcriptional regulatory protein
LE164_RS05790	COG0583	DNA-binding transcription factor activity
LE164_RS05795	COG2814	Major facilitator Superfamily
LE164_RS05800	COG2839	Protein conserved in bacteria
LE164_RS05825	COG1611	Belongs to the LOG family
LE164_RS05830	COG1671	Belongs to the UPF0178 family
LE164_RS05840	COG1968	undecaprenyl-diphosphatase activity
LE164_RS05850	COG0523	cobalamin synthesis protein
LE164_RS05865	COG0039	L-malate dehydrogenase activity
LE164_RS05870	COG0471	metal ion transport
LE164_RS05875	COG0415	Belongs to the DNA photolyase family
LE164_RS05900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LE164_RS05905	COG1349	DNA-binding transcription factor activity
LE164_RS05910	COG1105	Belongs to the carbohydrate kinase PfkB family
LE164_RS05915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LE164_RS05915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LE164_RS05915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS05920	COG1253	flavin adenine dinucleotide binding
LE164_RS05925	COG0656	L-ascorbic acid biosynthetic process
LE164_RS05930	COG0463	Glycosyl transferase, family 2
LE164_RS05945	COG0720	synthase
LE164_RS05955	COG0512	Glutamine amidotransferase of anthranilate synthase
LE164_RS05955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LE164_RS05960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LE164_RS05960	COG0512	Glutamine amidotransferase of anthranilate synthase
LE164_RS05970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LE164_RS05980	COG1368	sulfuric ester hydrolase activity
LE164_RS05990	COG0488	(ABC) transporter
LE164_RS05995	COG0514	ATP-dependent DNA helicase (RecQ)
LE164_RS06005	COG1174	glycine betaine transport
LE164_RS06010	COG3104	oligopeptide transport
LE164_RS06015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LE164_RS06025	COG1597	lipid kinase activity
LE164_RS06030	COG3104	oligopeptide transport
LE164_RS06035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LE164_RS06045	COG1780	Probably involved in ribonucleotide reductase function
LE164_RS06050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LE164_RS06055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LE164_RS06060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS06065	COG4605	iron ion homeostasis
LE164_RS06070	COG4604	ABC transporter, ATP-binding protein
LE164_RS06075	COG4607	ABC-type enterochelin transport system periplasmic component
LE164_RS06080	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS06085	COG4605	iron ion homeostasis
LE164_RS06090	COG4604	ABC transporter, ATP-binding protein
LE164_RS06095	COG4607	ABC-type enterochelin transport system periplasmic component
LE164_RS06105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LE164_RS06125	COG1929	Belongs to the glycerate kinase type-1 family
LE164_RS06130	COG2195	Cleaves the N-terminal amino acid of tripeptides
LE164_RS06145	COG2199	diguanylate cyclase activity
LE164_RS06150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LE164_RS06155	COG1739	Uncharacterized protein family UPF0029
LE164_RS06165	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LE164_RS06170	COG1040	competence protein
LE164_RS06175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LE164_RS06185	COG0653	protein targeting
LE164_RS06195	COG3942	CHAP domain
LE164_RS06195	COG1388	LysM domain
LE164_RS06215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LE164_RS06220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LE164_RS06225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LE164_RS06240	COG0492	ferredoxin-NADP+ reductase activity
LE164_RS06245	COG1660	Displays ATPase and GTPase activities
LE164_RS06250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LE164_RS06255	COG1481	regulation of sporulation
LE164_RS06260	COG0740	serine-type endopeptidase activity
LE164_RS06265	COG1090	epimerase
LE164_RS06285	COG0126	phosphoglycerate kinase activity
LE164_RS06290	COG0149	triose-phosphate isomerase activity
LE164_RS06295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LE164_RS06300	COG0148	phosphopyruvate hydratase activity
LE164_RS06310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LE164_RS06315	COG1647	Serine aminopeptidase, S33
LE164_RS06320	COG0557	exoribonuclease II activity
LE164_RS06380	COG1611	Belongs to the LOG family
LE164_RS06390	COG0346	lactoylglutathione lyase activity
LE164_RS06395	COG2259	Doxx family
LE164_RS06410	COG4195	phage-related replication protein
LE164_RS06445	COG0588	phosphoglycerate mutase activity
LE164_RS06455	COG1764	response to oxidative stress
LE164_RS06460	COG0710	3-dehydroquinate dehydratase activity
LE164_RS06470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LE164_RS06475	COG1393	Belongs to the ArsC family
LE164_RS06480	COG0509	glycine decarboxylation via glycine cleavage system
LE164_RS06485	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LE164_RS06495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LE164_RS06500	COG2011	ABC-type metal ion transport system permease component
LE164_RS06505	COG1464	Belongs to the NlpA lipoprotein family
LE164_RS06510	COG0582	viral genome integration into host DNA
LE164_RS06585	COG3728	DNA packaging
LE164_RS06585	COG5484	DNA packaging
LE164_RS06630	COG0396	ATPase activity
LE164_RS06635	COG0719	Fe-S assembly protein
LE164_RS06645	COG0822	iron-sulfur transferase activity
LE164_RS06650	COG0719	Fe-S assembly protein
LE164_RS06670	COG1388	LysM domain
LE164_RS06670	COG3942	CHAP domain
LE164_RS06785	COG1253	flavin adenine dinucleotide binding
LE164_RS06790	COG2070	2-Nitropropane dioxygenase
LE164_RS06795	COG1801	Protein of unknown function DUF72
LE164_RS06800	COG0730	response to heat
LE164_RS06805	COG0737	Belongs to the 5'-nucleotidase family
LE164_RS06810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LE164_RS06815	COG4470	Protein conserved in bacteria
LE164_RS06825	COG2445	Protein of unknown function DUF86
LE164_RS06830	COG0647	UMP catabolic process
LE164_RS06835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LE164_RS06845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LE164_RS06850	COG1696	Membrane protein involved in D-alanine export
LE164_RS06855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LE164_RS06860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LE164_RS06865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LE164_RS06870	COG4837	Protein of unknown function (DUF1462)
LE164_RS06875	COG1252	NADH dehydrogenase
LE164_RS06880	COG4844	belongs to the
LE164_RS06885	COG0316	Belongs to the HesB IscA family
LE164_RS06900	COG1021	2,3-dihydroxybenzoate-AMP ligase
LE164_RS06905	COG2226	methyltransferase
LE164_RS06905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LE164_RS06905	COG3433	isochorismatase activity
LE164_RS06935	COG1129	ABC transporter
LE164_RS06945	COG1132	(ABC) transporter
LE164_RS06955	COG1252	NADH dehydrogenase
LE164_RS06960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LE164_RS06965	COG2056	Na+-H+ antiporter family
LE164_RS06970	COG2050	protein possibly involved in aromatic compounds catabolism
LE164_RS06980	COG1320	monovalent cation:proton antiporter activity
LE164_RS06985	COG2212	antiporter activity
LE164_RS06990	COG1863	multisubunit Na H antiporter MnhE subunit
LE164_RS06995	COG0651	ATP synthesis coupled electron transport
LE164_RS07000	COG1006	Multisubunit Na H antiporter MnhC subunit
LE164_RS07005	COG2111	Na H antiporter
LE164_RS07010	COG2111	Na H antiporter
LE164_RS07010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LE164_RS07020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LE164_RS07025	COG1098	S1 RNA binding domain
LE164_RS07030	COG1902	pentaerythritol trinitrate reductase activity
LE164_RS07060	COG0137	argininosuccinate synthase activity
LE164_RS07065	COG0166	Belongs to the GPI family
LE164_RS07070	COG0398	Pfam SNARE associated Golgi protein
LE164_RS07090	COG1074	ATP-dependent DNA helicase activity
LE164_RS07105	COG0446	pyridine nucleotide-disulphide oxidoreductase
LE164_RS07110	COG0561	phosphatase activity
LE164_RS07120	COG0542	response to heat
LE164_RS07130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LE164_RS07145	COG0601	transmembrane transport
LE164_RS07150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LE164_RS07155	COG0444	Belongs to the ABC transporter superfamily
LE164_RS07160	COG4608	Belongs to the ABC transporter superfamily
LE164_RS07165	COG4166	transmembrane transport
LE164_RS07170	COG2226	methyltransferase
LE164_RS07175	COG0180	Tryptophanyl-tRNA synthetase
LE164_RS07180	COG1393	Belongs to the ArsC family
LE164_RS07195	COG1164	Oligoendopeptidase f
LE164_RS07205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LE164_RS07210	COG2346	COG2346, Truncated hemoglobins
LE164_RS07225	COG2357	RelA SpoT domain protein
LE164_RS07235	COG0564	pseudouridine synthase activity
LE164_RS07240	COG2239	Acts as a magnesium transporter
LE164_RS07245	COG0569	domain protein
LE164_RS07245	COG0475	glutathione-regulated potassium exporter activity
LE164_RS07255	COG0628	permease
LE164_RS07265	COG4221	oxidoreductase activity
LE164_RS07270	COG0789	Transcriptional regulator
LE164_RS07275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LE164_RS07280	COG2814	Major facilitator Superfamily
LE164_RS07285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LE164_RS07290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LE164_RS07305	COG0861	Integral membrane protein TerC family
LE164_RS07310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LE164_RS07310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LE164_RS07315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LE164_RS07320	COG0737	Belongs to the 5'-nucleotidase family
LE164_RS07330	COG4873	Protein conserved in bacteria
LE164_RS07390	COG1575	Belongs to the MenA family. Type 1 subfamily
LE164_RS07395	COG1169	isochorismate synthase
LE164_RS07400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LE164_RS07405	COG0596	Alpha beta hydrolase
LE164_RS07410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LE164_RS07420	COG3594	Acyltransferase
LE164_RS07450	COG1316	TRANSCRIPTIONal
LE164_RS07455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LE164_RS07465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LE164_RS07470	COG1845	cytochrome c oxidase, subunit III
LE164_RS07480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LE164_RS07490	COG1017	nitric oxide dioxygenase activity
LE164_RS07490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LE164_RS07500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LE164_RS07505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LE164_RS07510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LE164_RS07515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LE164_RS07520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LE164_RS07525	COG0047	phosphoribosylformylglycinamidine synthase activity
LE164_RS07530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LE164_RS07540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LE164_RS07550	COG0138	bifunctional purine biosynthesis protein purh
LE164_RS07555	COG0151	Belongs to the GarS family
LE164_RS07560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LE164_RS07565	COG4172	Belongs to the ABC transporter superfamily
LE164_RS07600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LE164_RS07615	COG0569	domain protein
LE164_RS07625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LE164_RS07630	COG5503	Protein of unknown function (DUF1447)
LE164_RS07635	COG0242	peptide deformylase activity
LE164_RS07650	COG0022	dehydrogenase e1 component
LE164_RS07665	COG4476	Belongs to the UPF0223 family
LE164_RS07685	COG1177	transmembrane transport
LE164_RS07690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LE164_RS07710	COG4493	Belongs to the UPF0637 family
LE164_RS07715	COG0483	inositol monophosphate 1-phosphatase activity
LE164_RS07725	COG1217	gtp-binding protein TYPA
LE164_RS07735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LE164_RS07740	COG4838	Belongs to the UPF0358 family
LE164_RS07745	COG0772	Belongs to the SEDS family
LE164_RS07760	COG1612	heme a metabolic process
LE164_RS07765	COG0109	protoheme IX farnesyltransferase activity
LE164_RS07780	COG3679	Belongs to the UPF0342 family
LE164_RS07800	COG0742	ribosomal rna small subunit methyltransferase
LE164_RS07805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LE164_RS07810	COG1323	Belongs to the UPF0348 family
LE164_RS07820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LE164_RS07825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LE164_RS07830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LE164_RS07835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LE164_RS07835	COG0072	phenylalanine-tRNA ligase activity
LE164_RS07840	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LE164_RS07845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LE164_RS07855	COG1796	DNA polymerase
LE164_RS07855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LE164_RS07860	COG1193	negative regulation of DNA recombination
LE164_RS07865	COG3118	belongs to the thioredoxin family
LE164_RS07870	COG0322	excinuclease ABC activity
LE164_RS07875	COG2009	succinate dehydrogenase
LE164_RS07880	COG1053	succinate dehydrogenase
LE164_RS07885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LE164_RS07890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LE164_RS07895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LE164_RS07905	COG1011	Hydrolase
LE164_RS07915	COG0454	-acetyltransferase
LE164_RS07920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LE164_RS07930	COG0275	rRNA processing
LE164_RS07935	COG4839	cell division protein FtsL
LE164_RS07940	COG0768	penicillin binding
LE164_RS07945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LE164_RS07950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LE164_RS07955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LE164_RS07960	COG0849	cell division
LE164_RS07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LE164_RS07970	COG1496	oxidoreductase activity
LE164_RS07975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LE164_RS07980	COG1799	cell septum assembly
LE164_RS07985	COG0762	integral membrane protein
LE164_RS07990	COG2302	S4 RNA-binding domain
LE164_RS07995	COG3599	regulation of cell shape
LE164_RS08000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LE164_RS08010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LE164_RS08015	COG0564	pseudouridine synthase activity
LE164_RS08020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LE164_RS08025	COG2233	PERMEase
LE164_RS08030	COG0540	Belongs to the ATCase OTCase family
LE164_RS08040	COG0505	Belongs to the CarA family
LE164_RS08050	COG0284	orotidine-5'-phosphate decarboxylase activity
LE164_RS08055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LE164_RS08075	COG0194	GDP metabolic process
LE164_RS08080	COG1758	RNA polymerase activity
LE164_RS08085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LE164_RS08090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LE164_RS08100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LE164_RS08105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LE164_RS08105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LE164_RS08115	COG0631	protein serine/threonine phosphatase activity
LE164_RS08130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LE164_RS08140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LE164_RS08145	COG1302	Protein conserved in bacteria
LE164_RS08150	COG1461	Dihydroxyacetone kinase
LE164_RS08155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LE164_RS08160	COG1349	DNA-binding transcription factor activity
LE164_RS08165	COG0416	fatty acid biosynthetic process
LE164_RS08180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LE164_RS08185	COG0571	ribonuclease III activity
LE164_RS08190	COG1196	nuclear chromosome segregation
LE164_RS08195	COG0552	protein localization to endoplasmic reticulum
LE164_RS08200	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LE164_RS08205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LE164_RS08210	COG0318	PFAM AMP-dependent synthetase and ligase
LE164_RS08215	COG0183	Belongs to the thiolase family
LE164_RS08230	COG0228	four-way junction DNA binding
LE164_RS08235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LE164_RS08240	COG0336	Belongs to the RNA methyltransferase TrmD family
LE164_RS08245	COG0335	large ribosomal subunit rRNA binding
LE164_RS08255	COG4485	Bacterial membrane protein, YfhO
LE164_RS08265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LE164_RS08270	COG0045	succinate-CoA ligase (ADP-forming) activity
LE164_RS08275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LE164_RS08285	COG2348	transferase activity, transferring amino-acyl groups
LE164_RS08290	COG0758	DNA mediated transformation
LE164_RS08295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LE164_RS08300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LE164_RS08305	COG4974	Belongs to the 'phage' integrase family
LE164_RS08310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LE164_RS08315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LE164_RS08320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LE164_RS08325	COG0052	Belongs to the universal ribosomal protein uS2 family
LE164_RS08330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LE164_RS08335	COG0528	UMP kinase activity
LE164_RS08340	COG0233	cytoplasmic translational termination
LE164_RS08345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LE164_RS08350	COG4589	Belongs to the CDS family
LE164_RS08365	COG0442	prolyl-tRNA aminoacylation
LE164_RS08370	COG2176	DNA-directed DNA polymerase activity
LE164_RS08375	COG0779	Required for maturation of 30S ribosomal subunits
LE164_RS08380	COG0195	Participates in both transcription termination and antitermination
LE164_RS08385	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LE164_RS08390	COG1358	cellular component organization or biogenesis
LE164_RS08395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LE164_RS08400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LE164_RS08410	COG0196	riboflavin kinase activity
LE164_RS08420	COG1185	polyribonucleotide nucleotidyltransferase activity
LE164_RS08425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LE164_RS08430	COG1674	ftsk spoiiie
LE164_RS08435	COG2188	Transcriptional regulator
LE164_RS08440	COG0612	Peptidase, M16
LE164_RS08445	COG0612	Peptidase, M16
LE164_RS08450	COG0300	oxidoreductase activity
LE164_RS08470	COG1058	Belongs to the CinA family
LE164_RS08470	COG1546	Belongs to the CinA family
LE164_RS08475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LE164_RS08480	COG1418	mRNA catabolic process
LE164_RS08490	COG1692	metallophosphoesterase
LE164_RS08495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LE164_RS08495	COG0674	pyruvate-flavodoxin oxidoreductase activity
LE164_RS08500	COG1013	pyruvate-flavodoxin oxidoreductase activity
LE164_RS08505	COG4195	phage-related replication protein
LE164_RS08515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LE164_RS08530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LE164_RS08535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LE164_RS08545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LE164_RS08550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LE164_RS08555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LE164_RS08565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LE164_RS08570	COG1923	regulation of RNA biosynthetic process
LE164_RS08580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LE164_RS08585	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LE164_RS08590	COG0789	Transcriptional regulator
LE164_RS08605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LE164_RS08610	COG1131	(ABC) transporter
LE164_RS08620	COG2203	Gaf domain
LE164_RS08620	COG4585	Histidine kinase
LE164_RS08625	COG2197	response regulator
LE164_RS08640	COG1525	nuclease
LE164_RS08655	COG0527	aspartate kinase activity
LE164_RS08660	COG0460	homoserine dehydrogenase
LE164_RS08665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LE164_RS08670	COG0083	homoserine kinase activity
LE164_RS08675	COG0561	phosphatase activity
LE164_RS08685	COG0833	amino acid
LE164_RS08700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LE164_RS08710	COG2340	Cysteine-rich secretory protein family
LE164_RS08715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LE164_RS08725	COG4224	UPF0291 protein
LE164_RS08730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LE164_RS08735	COG3763	UPF0154 protein
LE164_RS08740	COG4846	Membrane protein involved in cytochrome C biogenesis
LE164_RS08755	COG1970	mechanosensitive ion channel activity
LE164_RS08760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LE164_RS08765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LE164_RS08775	COG4841	protein insertion into membrane
LE164_RS08780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LE164_RS08785	COG0187	DNA topoisomerase II activity
LE164_RS08790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LE164_RS08795	COG1115	amino acid carrier protein
LE164_RS08800	COG0628	permease
LE164_RS08805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LE164_RS08805	COG0392	lysyltransferase activity
LE164_RS08825	COG1942	4-Oxalocrotonate Tautomerase
LE164_RS08830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LE164_RS08835	COG0287	Prephenate dehydrogenase
LE164_RS08855	COG3623	hexulose-6-phosphate isomerase
LE164_RS08865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LE164_RS08880	COG1363	Peptidase, m42
LE164_RS08885	COG0328	RNA-DNA hybrid ribonuclease activity
LE164_RS08890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LE164_RS08900	COG1413	lyase activity
LE164_RS08930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LE164_RS08940	COG4479	Belongs to the UPF0346 family
LE164_RS08945	COG0793	Belongs to the peptidase S41A family
LE164_RS08955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LE164_RS08960	COG0671	phosphoesterase, PA-phosphatase related
LE164_RS08970	COG0745	RESPONSE REGULATOR receiver
LE164_RS08975	COG5002	protein histidine kinase activity
LE164_RS08980	COG0567	Dehydrogenase, E1 component
LE164_RS09000	COG0714	Associated with various cellular activities
LE164_RS09005	COG4548	von Willebrand factor, type A
LE164_RS09010	COG1114	Component of the transport system for branched-chain amino acids
LE164_RS09015	COG3853	Toxic anion resistance protein (TelA)
LE164_RS09025	COG1254	Belongs to the acylphosphatase family
LE164_RS09035	COG1278	Cold shock
LE164_RS09055	COG1473	amidohydrolase
LE164_RS09060	COG2171	N-acyltransferase activity
LE164_RS09065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LE164_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LE164_RS09075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LE164_RS09080	COG0527	aspartate kinase activity
LE164_RS09085	COG0488	(ABC) transporter
LE164_RS09090	COG2996	Protein conserved in bacteria
LE164_RS09095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LE164_RS09100	COG0573	inorganic phosphate transmembrane transporter activity
LE164_RS09105	COG0581	inorganic phosphate transmembrane transporter activity
LE164_RS09110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LE164_RS09120	COG1164	Oligoendopeptidase f
LE164_RS09130	COG4607	ABC-type enterochelin transport system periplasmic component
LE164_RS09135	COG0561	phosphatase activity
LE164_RS09140	COG2348	transferase activity, transferring amino-acyl groups
LE164_RS09145	COG2348	transferase activity, transferring amino-acyl groups
LE164_RS09160	COG0135	phosphoribosylanthranilate isomerase activity
LE164_RS09165	COG0134	indole-3-glycerol-phosphate synthase activity
LE164_RS09170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LE164_RS09175	COG0512	Glutamine amidotransferase of anthranilate synthase
LE164_RS09180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LE164_RS09185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LE164_RS09190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LE164_RS09200	COG0116	Belongs to the methyltransferase superfamily
LE164_RS09210	COG3599	regulation of cell shape
LE164_RS09215	COG4474	Belongs to the UPF0398 family
LE164_RS09230	COG4499	WXG100 protein secretion system (Wss), protein YukC
LE164_RS09230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LE164_RS09240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LE164_RS09245	COG3935	DnaD domain protein
LE164_RS09250	COG0017	Asparaginyl-tRNA synthetase
LE164_RS09255	COG1199	ATP-dependent helicase activity
LE164_RS09255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LE164_RS09260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LE164_RS09260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LE164_RS09265	COG0617	tRNA 3'-terminal CCA addition
LE164_RS09270	COG0438	transferase activity, transferring glycosyl groups
LE164_RS09275	COG1694	Mazg nucleotide pyrophosphohydrolase
LE164_RS09280	COG2738	Putative neutral zinc metallopeptidase
LE164_RS09305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LE164_RS09310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LE164_RS09320	COG0142	geranyltranstransferase activity
LE164_RS09325	COG2226	methyltransferase
LE164_RS09340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LE164_RS09350	COG0539	negative regulation of cytoplasmic translation
LE164_RS09370	COG0492	ferredoxin-NADP+ reductase activity
LE164_RS09375	COG1388	LysM domain
LE164_RS09380	COG0514	ATP-dependent DNA helicase (RecQ)
LE164_RS09390	COG1141	Ferredoxin
LE164_RS09405	COG0745	RESPONSE REGULATOR receiver
LE164_RS09410	COG1187	pseudouridine synthase activity
LE164_RS09415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LE164_RS09420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LE164_RS09430	COG4974	Belongs to the 'phage' integrase family
LE164_RS09435	COG0735	belongs to the Fur family
LE164_RS09440	COG0494	nUDIX hydrolase
LE164_RS09445	COG0667	Aldo Keto reductase
LE164_RS09450	COG0300	oxidoreductase activity
LE164_RS09455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LE164_RS09465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LE164_RS09475	COG0366	Alpha amylase catalytic
LE164_RS09480	COG1609	Transcriptional regulator
LE164_RS09490	COG2195	Cleaves the N-terminal amino acid of tripeptides
LE164_RS09500	COG4129	membrane
LE164_RS09510	COG0508	dehydrogenase complex catalyzes the overall conversion of
LE164_RS09515	COG0022	dehydrogenase e1 component
LE164_RS09520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LE164_RS09525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LE164_RS09530	COG0280	phosphate acetyltransferase
LE164_RS09535	COG0497	DNA recombination
LE164_RS09540	COG1438	arginine binding
LE164_RS09560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LE164_RS09565	COG1302	Protein conserved in bacteria
LE164_RS09570	COG0439	Biotin carboxylase
LE164_RS09575	COG0511	ligase activity, forming carbon-carbon bonds
LE164_RS09580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LE164_RS09585	COG0006	proline dipeptidase activity
LE164_RS09600	COG0095	Lipoate-protein ligase
LE164_RS09605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LE164_RS09610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LE164_RS09615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LE164_RS09620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LE164_RS09625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LE164_RS09640	COG4537	Required for transformation and DNA binding
LE164_RS09645	COG1459	type II secretion system
LE164_RS09650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LE164_RS09655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LE164_RS09660	COG0011	TIGRFAM Protein of
LE164_RS09665	COG1940	carbohydrate kinase activity
LE164_RS09670	COG4483	Protein conserved in bacteria
LE164_RS09675	COG0457	Tetratricopeptide repeat
LE164_RS09675	COG0705	Rhomboid family
LE164_RS09680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LE164_RS09685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LE164_RS09690	COG0768	penicillin binding
LE164_RS09695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LE164_RS09705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LE164_RS09710	COG1121	(ABC) transporter
LE164_RS09715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LE164_RS09720	COG0513	Belongs to the DEAD box helicase family
LE164_RS09730	COG2384	SAM-dependent methyltransferase
LE164_RS09745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LE164_RS09750	COG0517	IMP dehydrogenase activity
LE164_RS09755	COG0423	glycine-tRNA ligase activity
LE164_RS09760	COG1381	Involved in DNA repair and RecF pathway recombination
LE164_RS09765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LE164_RS09770	COG0295	cytidine deaminase activity
LE164_RS09775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LE164_RS09780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LE164_RS09785	COG1702	phosphate starvation-inducible protein PhoH
LE164_RS09795	COG4864	UPF0365 protein
LE164_RS09800	COG1030	water channel activity
LE164_RS09810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LE164_RS09815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LE164_RS09820	COG2264	protein methyltransferase activity
LE164_RS09825	COG0484	heat shock protein binding
LE164_RS09830	COG0443	Heat shock 70 kDa protein
LE164_RS09835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LE164_RS09845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LE164_RS09850	COG0481	GTPase activity
LE164_RS09855	COG0268	Binds directly to 16S ribosomal RNA
LE164_RS09860	COG1466	dna polymerase III delta subunit
LE164_RS09865	COG0658	competence protein
LE164_RS09865	COG2333	competence protein COMEC
LE164_RS09870	COG2131	deaminase
LE164_RS09875	COG1555	photosystem II stabilization
LE164_RS09875	COG1596	polysaccharide export
LE164_RS09880	COG2226	methyltransferase
LE164_RS09885	COG0799	negative regulation of ribosome biogenesis
LE164_RS09890	COG1713	HD superfamily hydrolase involved in NAD metabolism
LE164_RS09895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LE164_RS09900	COG1534	Rna-binding protein
LE164_RS09910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LE164_RS09915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LE164_RS09920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LE164_RS09925	COG1914	H( )-stimulated, divalent metal cation uptake system
LE164_RS09935	COG0439	Biotin carboxylase
LE164_RS09940	COG0511	ligase activity, forming carbon-carbon bonds
LE164_RS09945	COG1984	allophanate hydrolase subunit 2
LE164_RS09950	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LE164_RS09955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LE164_RS09960	COG0572	uridine kinase
LE164_RS09965	COG0826	peptidase U32
LE164_RS09970	COG0826	peptidase U32
LE164_RS09975	COG4122	O-methyltransferase activity
LE164_RS09985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LE164_RS09990	COG4472	Bacterial protein of unknown function (DUF965)
LE164_RS09995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LE164_RS10000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LE164_RS10010	COG0482	sulfurtransferase activity
LE164_RS10015	COG1104	cysteine desulfurase activity
LE164_RS10020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LE164_RS10030	COG1959	2 iron, 2 sulfur cluster binding
LE164_RS10035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LE164_RS10040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LE164_RS10050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LE164_RS10055	COG0124	histidyl-tRNA synthetase
LE164_RS10060	COG0860	N-Acetylmuramoyl-L-alanine amidase
LE164_RS10065	COG1490	D-aminoacyl-tRNA deacylase activity
LE164_RS10070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LE164_RS10080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LE164_RS10080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LE164_RS10085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LE164_RS10085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LE164_RS10090	COG1862	Preprotein translocase
LE164_RS10095	COG0343	queuine tRNA-ribosyltransferase activity
LE164_RS10100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LE164_RS10105	COG2255	four-way junction helicase activity
LE164_RS10110	COG0632	four-way junction helicase activity
LE164_RS10115	COG4492	Belongs to the UPF0735 family
LE164_RS10120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LE164_RS10130	COG2868	ribosomal protein
LE164_RS10135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LE164_RS10145	COG1792	Involved in formation and maintenance of cell shape
LE164_RS10165	COG2003	Belongs to the UPF0758 family
LE164_RS10175	COG0285	dihydrofolate synthase activity
LE164_RS10180	COG0525	valine-tRNA ligase activity
LE164_RS10185	COG2818	Glycosylase
LE164_RS10195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LE164_RS10210	COG0181	hydroxymethylbilane synthase activity
LE164_RS10215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LE164_RS10230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LE164_RS10235	COG0544	peptidyl-prolyl cis-trans isomerase activity
LE164_RS10245	COG4112	unkown
LE164_RS10250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LE164_RS10255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LE164_RS10260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LE164_RS10265	COG0833	amino acid
LE164_RS10275	COG1484	DNA-dependent DNA replication
LE164_RS10280	COG3611	Membrane attachment protein
LE164_RS10285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LE164_RS10290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LE164_RS10295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LE164_RS10300	COG0237	dephospho-CoA kinase activity
LE164_RS10305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LE164_RS10310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LE164_RS10310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LE164_RS10315	COG5002	protein histidine kinase activity
LE164_RS10320	COG0745	RESPONSE REGULATOR receiver
LE164_RS10325	COG0538	isocitrate dehydrogenase activity
LE164_RS10330	COG0372	Belongs to the citrate synthase family
LE164_RS10335	COG1113	amino acid transport
LE164_RS10340	COG0469	pyruvate kinase activity
LE164_RS10345	COG0205	6-phosphofructokinase activity
LE164_RS10350	COG0825	malonyl-CoA metabolic process
LE164_RS10355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LE164_RS10360	COG0281	malic enzyme
LE164_RS10365	COG0587	DNA-directed DNA polymerase activity
LE164_RS10370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LE164_RS10375	COG4109	DRTGG domain
LE164_RS10385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LE164_RS10390	COG0006	proline dipeptidase activity
LE164_RS10395	COG0686	Belongs to the AlaDH PNT family
LE164_RS10400	COG0589	response to stress
LE164_RS10405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LE164_RS10410	COG0827	DNA restriction-modification system
LE164_RS10415	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LE164_RS10420	COG0730	response to heat
LE164_RS10425	COG0301	tRNA thio-modification
LE164_RS10430	COG1104	cysteine desulfurase activity
LE164_RS10435	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LE164_RS10440	COG1956	GAF domain-containing protein
LE164_RS10445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LE164_RS10450	COG0584	glycerophosphoryl diester phosphodiesterase
LE164_RS10455	COG1764	response to oxidative stress
LE164_RS10460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LE164_RS10465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LE164_RS10475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LE164_RS10475	COG1263	PTS System
LE164_RS10480	COG0204	Acyl-transferase
LE164_RS10485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LE164_RS10490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LE164_RS10500	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LE164_RS10505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LE164_RS10510	COG0454	-acetyltransferase
LE164_RS10515	COG0123	including yeast histone deacetylase and acetoin utilization protein
LE164_RS10530	COG1609	Transcriptional regulator
LE164_RS10535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LE164_RS10535	COG1605	Chorismate mutase
LE164_RS10545	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LE164_RS10550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LE164_RS10555	COG1674	ftsk spoiiie
LE164_RS10560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LE164_RS10565	COG4848	Belongs to the UPF0354 family
LE164_RS10570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LE164_RS10575	COG1363	Peptidase, m42
LE164_RS10580	COG5584	Small secreted protein
LE164_RS10585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LE164_RS10590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LE164_RS10595	COG0510	thiamine kinase activity
LE164_RS10605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LE164_RS10615	COG1187	pseudouridine synthase activity
LE164_RS10620	COG2244	polysaccharide biosynthetic process
LE164_RS10625	COG2081	HI0933 family
LE164_RS10635	COG0495	leucyl-tRNA aminoacylation
LE164_RS10640	COG2814	Major facilitator Superfamily
LE164_RS10645	COG1242	4 iron, 4 sulfur cluster binding
LE164_RS10650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LE164_RS10660	COG2267	carboxylic ester hydrolase activity
LE164_RS10665	COG0506	proline dehydrogenase activity
LE164_RS10670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LE164_RS10675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LE164_RS10675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LE164_RS10685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LE164_RS10685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LE164_RS10695	COG5632	N-Acetylmuramoyl-L-alanine amidase
LE164_RS10695	COG4193	domain, Protein
LE164_RS10695	COG3266	domain, Protein
LE164_RS10720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LE164_RS10735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LE164_RS10740	COG0656	L-ascorbic acid biosynthetic process
LE164_RS10750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LE164_RS10755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LE164_RS10760	COG1506	peptidase
LE164_RS10770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LE164_RS10780	COG0318	PFAM AMP-dependent synthetase and ligase
LE164_RS10830	COG3545	Serine hydrolase
LE164_RS10835	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LE164_RS10845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LE164_RS10850	COG2329	Antibiotic biosynthesis monooxygenase
LE164_RS10855	COG4473	ABC transporter
LE164_RS10860	COG1131	(ABC) transporter
LE164_RS10865	COG0537	adenosine 5'-monophosphoramidase activity
LE164_RS10880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LE164_RS10900	COG0420	3'-5' exonuclease activity
LE164_RS10905	COG3679	Belongs to the UPF0342 family
LE164_RS10920	COG2197	response regulator
LE164_RS10925	COG4585	Histidine kinase
LE164_RS10925	COG2203	Gaf domain
LE164_RS10930	COG0564	pseudouridine synthase activity
LE164_RS10935	COG0114	fumarate hydratase activity
LE164_RS10950	COG0363	glucosamine-6-phosphate deaminase activity
LE164_RS10960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LE164_RS10965	COG1126	abc transporter atp-binding protein
LE164_RS10970	COG0765	amino acid transport
LE164_RS11140	COG0735	belongs to the Fur family
LE164_RS11150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LE164_RS11155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LE164_RS11160	COG4129	membrane
LE164_RS11170	COG3557	Belongs to the UPF0374 family
LE164_RS11175	COG1194	a g-specific adenine glycosylase
LE164_RS11180	COG1988	membrane-bound metal-dependent
LE164_RS11190	COG1134	teichoic acid transport
LE164_RS11190	COG1388	LysM domain
LE164_RS11200	COG2137	regulation of response to DNA damage stimulus
LE164_RS11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LE164_RS11210	COG0693	protein deglycase activity
LE164_RS11220	COG0535	radical SAM domain protein
LE164_RS11225	COG1607	acyl-coa hydrolase
LE164_RS11230	COG2309	aminopeptidase activity
LE164_RS11235	COG4840	Belongs to the UPF0435 family
LE164_RS11240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LE164_RS11250	COG1295	ribonuclease BN
LE164_RS11275	COG0024	Methionine aminopeptidase
LE164_RS11280	COG4129	membrane
LE164_RS11285	COG0446	pyridine nucleotide-disulphide oxidoreductase
LE164_RS11305	COG1528	Iron-storage protein
LE164_RS11330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LE164_RS11335	COG1597	lipid kinase activity
LE164_RS11340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LE164_RS11345	COG0154	amidase activity
LE164_RS11355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LE164_RS11365	COG4851	CamS sex pheromone cAM373 precursor
LE164_RS11370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LE164_RS11380	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LE164_RS11385	COG4496	protein, YerC YecD
LE164_RS11390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LE164_RS11400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LE164_RS11405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LE164_RS11410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LE164_RS11420	COG0077	Prephenate dehydratase
LE164_RS11435	COG1335	isochorismatase
LE164_RS11440	COG1227	inorganic diphosphatase activity
LE164_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
LE164_RS11450	COG2706	6-phosphogluconolactonase activity
LE164_RS11490	COG1131	(ABC) transporter
LE164_RS11500	COG0842	Transport permease protein
LE164_RS11500	COG1129	ABC transporter
LE164_RS11505	COG1725	Transcriptional regulator
LE164_RS11520	COG0459	protein refolding
LE164_RS11545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LE164_RS11550	COG4512	PFAM Accessory gene regulator B
LE164_RS11570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LE164_RS11575	COG1621	beta-fructofuranosidase activity
LE164_RS11580	COG1609	Transcriptional regulator
LE164_RS11585	COG0004	ammonium transporteR
LE164_RS11590	COG0425	Belongs to the sulfur carrier protein TusA family
LE164_RS11595	COG2391	methyltransferase activity
LE164_RS11600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LE164_RS11605	COG0488	(ABC) transporter
LE164_RS11615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LE164_RS11620	COG0456	acetyltransferase
LE164_RS11625	COG1214	PFAM Peptidase M22, glycoprotease
LE164_RS11630	COG0802	atpase or kinase
LE164_RS11640	COG0028	Belongs to the TPP enzyme family
LE164_RS11650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LE164_RS11655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LE164_RS11665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LE164_RS11670	COG0066	3-isopropylmalate dehydratase activity
LE164_RS11675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LE164_RS11715	COG2183	response to ionizing radiation
LE164_RS11720	COG1191	sigma factor activity
LE164_RS11735	COG2208	phosphoserine phosphatase activity
LE164_RS11740	COG2337	Toxic component of a toxin-antitoxin (TA) module
LE164_RS11755	COG0736	holo-[acyl-carrier-protein] synthase activity
LE164_RS11765	COG3428	Bacterial PH domain
LE164_RS11775	COG0513	Belongs to the DEAD box helicase family
LE164_RS11780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LE164_RS11785	COG1181	Belongs to the D-alanine--D-alanine ligase family
LE164_RS11790	COG0772	Belongs to the SEDS family
LE164_RS11805	COG1937	Protein conserved in bacteria
LE164_RS11810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LE164_RS11815	COG1418	mRNA catabolic process
LE164_RS11820	COG0706	membrane insertase activity
LE164_RS11825	COG0352	thiamine-phosphate diphosphorylase activity
LE164_RS11830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LE164_RS11840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LE164_RS11850	COG0629	single-stranded DNA binding
LE164_RS11860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LE164_RS11865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LE164_RS11870	COG4836	Membrane
LE164_RS11880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LE164_RS11885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LE164_RS11895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LE164_RS11900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LE164_RS11905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LE164_RS11910	COG0356	it plays a direct role in the translocation of protons across the membrane
LE164_RS11925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LE164_RS11930	COG4475	Protein of unknown function (DUF436)
LE164_RS11935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LE164_RS11940	COG0009	L-threonylcarbamoyladenylate synthase
LE164_RS11945	COG2890	protein-(glutamine-N5) methyltransferase activity
LE164_RS11950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LE164_RS11960	COG0254	rRNA binding
LE164_RS11965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LE164_RS11970	COG1012	belongs to the aldehyde dehydrogenase family
LE164_RS11980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LE164_RS11985	COG0191	fructose-bisphosphate aldolase activity
LE164_RS11995	COG0504	CTP synthase activity
LE164_RS12000	COG3343	RNA polymerase activity
LE164_RS12010	COG5146	pantothenate kinase activity
LE164_RS12030	COG1854	S-ribosylhomocysteine lyase activity
LE164_RS12060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LE164_RS12065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LE164_RS12070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LE164_RS12075	COG0813	purine-nucleoside phosphorylase activity
LE164_RS12080	COG0783	Belongs to the Dps family
LE164_RS12100	COG1482	cell wall glycoprotein biosynthetic process
LE164_RS12105	COG0702	epimerase
LE164_RS12110	COG0640	Transcriptional regulator
LE164_RS12130	COG0561	phosphatase activity
LE164_RS12200	COG0489	protein tyrosine kinase activity
LE164_RS12205	COG2814	Major facilitator Superfamily
LE164_RS12220	COG1272	protein, Hemolysin III
LE164_RS12225	COG4284	Utp--glucose-1-phosphate uridylyltransferase
LE164_RS12230	COG1988	membrane-bound metal-dependent
LE164_RS12240	COG3314	Sporulation integral membrane protein YlbJ
LE164_RS12245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS12250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LE164_RS12255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LE164_RS12285	COG0604	alcohol dehydrogenase
LE164_RS12290	COG2130	NADP-dependent
LE164_RS12300	COG2723	6-phospho-beta-galactosidase activity
LE164_RS12315	COG1388	LysM domain
LE164_RS12315	COG5632	N-Acetylmuramoyl-L-alanine amidase
LE164_RS12430	COG1783	phage Terminase large subunit
LE164_RS12460	COG0756	dUTP diphosphatase activity
LE164_RS12505	COG1484	DNA-dependent DNA replication
LE164_RS12610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LE164_RS12620	COG1447	Phosphotransferase system cellobiose-specific component IIA
LE164_RS12625	COG3684	Belongs to the aldolase LacD family
LE164_RS12630	COG1105	Belongs to the carbohydrate kinase PfkB family
LE164_RS12635	COG0698	ribose 5-phosphate isomerase
LE164_RS12640	COG0698	ribose 5-phosphate isomerase
LE164_RS12645	COG1349	DNA-binding transcription factor activity
LE164_RS12650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LE164_RS12725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LE164_RS12790	COG0583	DNA-binding transcription factor activity
LE164_RS12820	COG3682	Transcriptional regulator
LE164_RS12975	COG3682	Transcriptional regulator