locus-tag	class	description
FO458_RS00015	COG0167	dihydroorotate dehydrogenase activity
FO458_RS00020	COG3001	Fructosamine kinase
FO458_RS00025	COG0596	Alpha beta hydrolase
FO458_RS00035	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS00075	COG2814	Major facilitator Superfamily
FO458_RS00085	COG1113	amino acid transport
FO458_RS00100	COG3189	MarR family transcriptional regulator
FO458_RS00120	COG0436	Aminotransferase
FO458_RS00130	COG2608	mercury ion transmembrane transporter activity
FO458_RS00135	COG2217	Heavy metal translocating P-type atpase
FO458_RS00145	COG0110	maltose O-acetyltransferase activity
FO458_RS00150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS00155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO458_RS00160	COG1012	belongs to the aldehyde dehydrogenase family
FO458_RS00185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FO458_RS00210	COG1131	(ABC) transporter
FO458_RS00220	COG3425	synthase
FO458_RS00235	COG3942	CHAP domain
FO458_RS00235	COG1388	LysM domain
FO458_RS00245	COG0583	DNA-binding transcription factor activity
FO458_RS00250	COG1380	Effector of murein hydrolase LrgA
FO458_RS00255	COG1346	cytolysis
FO458_RS00260	COG0028	Belongs to the TPP enzyme family
FO458_RS00275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO458_RS00285	COG0039	L-malate dehydrogenase activity
FO458_RS00290	COG0657	acetylesterase activity
FO458_RS00300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO458_RS00320	COG1070	Carbohydrate kinase
FO458_RS00330	COG1760	l-serine dehydratase
FO458_RS00335	COG1760	l-serine dehydratase
FO458_RS00345	COG3764	Sortase (surface protein transpeptidase)
FO458_RS00355	COG0561	phosphatase activity
FO458_RS00360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO458_RS00365	COG0778	Nitroreductase
FO458_RS00375	COG1012	belongs to the aldehyde dehydrogenase family
FO458_RS00380	COG2514	catechol 2,3-dioxygenase activity
FO458_RS00385	COG2388	GCN5-related N-acetyl-transferase
FO458_RS00420	COG1846	Transcriptional regulator
FO458_RS00425	COG0346	lactoylglutathione lyase activity
FO458_RS00430	COG0346	lactoylglutathione lyase activity
FO458_RS00435	COG0400	carboxylic ester hydrolase activity
FO458_RS00440	COG3949	Membrane
FO458_RS00450	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FO458_RS00455	COG1733	regulation of RNA biosynthetic process
FO458_RS00465	COG1902	pentaerythritol trinitrate reductase activity
FO458_RS00470	COG0586	Pfam SNARE associated Golgi protein
FO458_RS00480	COG2022	thiamine diphosphate biosynthetic process
FO458_RS00500	COG2271	Major facilitator Superfamily
FO458_RS00515	COG4876	unkown
FO458_RS00520	COG2357	RelA SpoT domain protein
FO458_RS00535	COG1802	Transcriptional regulator
FO458_RS00540	COG1070	Carbohydrate kinase
FO458_RS00545	COG2610	gluconate transmembrane transporter activity
FO458_RS00550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FO458_RS00565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FO458_RS00570	COG0438	transferase activity, transferring glycosyl groups
FO458_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO458_RS00605	COG4221	oxidoreductase activity
FO458_RS00610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO458_RS00615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FO458_RS00625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FO458_RS00630	COG1363	Peptidase, m42
FO458_RS00650	COG3639	organic phosphonate transmembrane transporter activity
FO458_RS00655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FO458_RS00670	COG0737	Belongs to the 5'-nucleotidase family
FO458_RS00675	COG0069	glutamate synthase activity
FO458_RS00690	COG4619	ABC transporter
FO458_RS00695	COG0390	transport system, permease component
FO458_RS00700	COG2205	protein histidine kinase activity
FO458_RS00705	COG0745	RESPONSE REGULATOR receiver
FO458_RS00715	COG2814	Major facilitator Superfamily
FO458_RS00720	COG2272	Belongs to the type-B carboxylesterase lipase family
FO458_RS00725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FO458_RS00730	COG1063	alcohol dehydrogenase
FO458_RS00750	COG1174	glycine betaine transport
FO458_RS00780	COG1346	cytolysis
FO458_RS00785	COG1380	Effector of murein hydrolase LrgA
FO458_RS00790	COG3279	Response regulator of the LytR AlgR family
FO458_RS00795	COG3275	phosphorelay sensor kinase activity
FO458_RS00805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FO458_RS00820	COG0706	membrane insertase activity
FO458_RS00830	COG0531	amino acid
FO458_RS00845	COG1113	amino acid transport
FO458_RS00865	COG2814	Major facilitator Superfamily
FO458_RS00875	COG1929	Belongs to the glycerate kinase type-1 family
FO458_RS00885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FO458_RS00890	COG0741	lytic transglycosylase activity
FO458_RS00895	COG0588	phosphoglycerate mutase activity
FO458_RS00905	COG2814	Major facilitator Superfamily
FO458_RS00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO458_RS00915	COG0765	amino acid transport
FO458_RS00920	COG1126	abc transporter atp-binding protein
FO458_RS00960	COG1131	(ABC) transporter
FO458_RS00970	COG2116	formate transmembrane transporter activity
FO458_RS00980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO458_RS00985	COG2146	nitrite reductase [NAD(P)H] activity
FO458_RS00995	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FO458_RS01000	COG1140	nitrate reductase beta subunit
FO458_RS01010	COG2181	nitrate reductase activity
FO458_RS01020	COG4585	Histidine kinase
FO458_RS01030	COG2223	nitrite transmembrane transporter activity
FO458_RS01035	COG1846	Transcriptional regulator
FO458_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS01075	COG1263	PTS System
FO458_RS01100	COG0534	Mate efflux family protein
FO458_RS01110	COG1124	(ABC) transporter
FO458_RS01115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO458_RS01125	COG0601	transmembrane transport
FO458_RS01135	COG0829	nickel cation binding
FO458_RS01150	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FO458_RS01155	COG0804	urea catabolic process
FO458_RS01165	COG0831	urea catabolic process
FO458_RS01170	COG4413	Urea transporter
FO458_RS01180	COG4716	Myosin-crossreactive antigen
FO458_RS01185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FO458_RS01190	COG2962	Rard protein
FO458_RS01205	COG0488	(ABC) transporter
FO458_RS01230	COG2814	Major facilitator Superfamily
FO458_RS01235	COG0583	DNA-binding transcription factor activity
FO458_RS01275	COG2314	TM2 domain
FO458_RS01280	COG0492	ferredoxin-NADP+ reductase activity
FO458_RS01295	COG0604	alcohol dehydrogenase
FO458_RS01300	COG2822	iron ion transport
FO458_RS01305	COG2837	iron assimilation
FO458_RS01310	COG0672	)-iron permease
FO458_RS01315	COG0805	protein transport
FO458_RS01320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FO458_RS01325	COG0456	acetyltransferase
FO458_RS01335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS01340	COG1620	l-lactate permease
FO458_RS01345	COG0297	glycogen (starch) synthase activity
FO458_RS01350	COG0579	oxidoreductase
FO458_RS01400	COG2814	Major facilitator Superfamily
FO458_RS01410	COG1566	PFAM secretion protein HlyD family protein
FO458_RS01415	COG2814	Major facilitator Superfamily
FO458_RS01440	COG0598	Magnesium transport protein CorA
FO458_RS01445	COG1304	FMN binding
FO458_RS01450	COG2094	Belongs to the DNA glycosylase MPG family
FO458_RS01460	COG2017	converts alpha-aldose to the beta-anomer
FO458_RS01465	COG2258	MOSC domain
FO458_RS01470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FO458_RS01475	COG1266	CAAX protease self-immunity
FO458_RS01485	COG1473	amidohydrolase
FO458_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS01510	COG1737	Transcriptional regulator
FO458_RS01515	COG1263	PTS System
FO458_RS01515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS01525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FO458_RS01545	COG1113	amino acid transport
FO458_RS01550	COG1737	Transcriptional regulator
FO458_RS01555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS01555	COG1263	PTS System
FO458_RS01560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FO458_RS01570	COG1349	DNA-binding transcription factor activity
FO458_RS01580	COG1316	TRANSCRIPTIONal
FO458_RS01605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO458_RS01620	COG3942	CHAP domain
FO458_RS01635	COG1757	Na H antiporter
FO458_RS01640	COG3942	CHAP domain
FO458_RS01670	COG1960	acyl-CoA dehydrogenase activity
FO458_RS01675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO458_RS01685	COG1268	BioY protein
FO458_RS01695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FO458_RS01700	COG0725	ABC transporter, periplasmic molybdate-binding protein
FO458_RS01705	COG4149	molybdate abc transporter
FO458_RS01710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FO458_RS01715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FO458_RS01750	COG0746	molybdenum cofactor guanylyltransferase activity
FO458_RS01755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FO458_RS01780	COG2348	transferase activity, transferring amino-acyl groups
FO458_RS01785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FO458_RS01810	COG2252	PERMEase
FO458_RS01825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FO458_RS01830	COG0088	Forms part of the polypeptide exit tunnel
FO458_RS01835	COG0089	rRNA binding
FO458_RS01840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FO458_RS01845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FO458_RS01855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FO458_RS01860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FO458_RS01870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FO458_RS01880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FO458_RS01895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FO458_RS01900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FO458_RS01905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FO458_RS01910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FO458_RS01915	COG1841	ribosomal large subunit assembly
FO458_RS01925	COG0201	protein transport
FO458_RS01930	COG0563	adenylate kinase activity
FO458_RS01935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FO458_RS01940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FO458_RS01945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FO458_RS01955	COG0202	RNA polymerase activity
FO458_RS01960	COG0203	ribosomal protein L17
FO458_RS01970	COG1122	ATPase activity
FO458_RS01980	COG0101	tRNA pseudouridine synthase activity
FO458_RS01985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FO458_RS02005	COG1131	(ABC) transporter
FO458_RS02015	COG1131	(ABC) transporter
FO458_RS02025	COG1309	transcriptional regulator
FO458_RS02070	COG1349	DNA-binding transcription factor activity
FO458_RS02075	COG0698	ribose 5-phosphate isomerase
FO458_RS02080	COG0698	ribose 5-phosphate isomerase
FO458_RS02085	COG1105	Belongs to the carbohydrate kinase PfkB family
FO458_RS02090	COG3684	Belongs to the aldolase LacD family
FO458_RS02095	COG1447	Phosphotransferase system cellobiose-specific component IIA
FO458_RS02100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FO458_RS02100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FO458_RS02105	COG2723	6-phospho-beta-galactosidase activity
FO458_RS02115	COG2130	NADP-dependent
FO458_RS02120	COG0604	alcohol dehydrogenase
FO458_RS02150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FO458_RS02155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS02160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS02165	COG3314	Sporulation integral membrane protein YlbJ
FO458_RS02175	COG1988	membrane-bound metal-dependent
FO458_RS02180	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FO458_RS02185	COG1272	protein, Hemolysin III
FO458_RS02200	COG2814	Major facilitator Superfamily
FO458_RS02205	COG0489	protein tyrosine kinase activity
FO458_RS02275	COG0561	phosphatase activity
FO458_RS02295	COG0640	Transcriptional regulator
FO458_RS02300	COG0702	epimerase
FO458_RS02305	COG1482	cell wall glycoprotein biosynthetic process
FO458_RS02325	COG0783	Belongs to the Dps family
FO458_RS02330	COG0813	purine-nucleoside phosphorylase activity
FO458_RS02335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FO458_RS02340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FO458_RS02345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FO458_RS02375	COG1854	S-ribosylhomocysteine lyase activity
FO458_RS02395	COG5146	pantothenate kinase activity
FO458_RS02405	COG3343	RNA polymerase activity
FO458_RS02410	COG0504	CTP synthase activity
FO458_RS02420	COG0191	fructose-bisphosphate aldolase activity
FO458_RS02425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO458_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
FO458_RS02440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FO458_RS02445	COG0254	rRNA binding
FO458_RS02455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FO458_RS02460	COG2890	protein-(glutamine-N5) methyltransferase activity
FO458_RS02465	COG0009	L-threonylcarbamoyladenylate synthase
FO458_RS02470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO458_RS02475	COG4475	Protein of unknown function (DUF436)
FO458_RS02480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FO458_RS02495	COG0356	it plays a direct role in the translocation of protons across the membrane
FO458_RS02500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO458_RS02505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FO458_RS02520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FO458_RS02525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FO458_RS02535	COG4836	Membrane
FO458_RS02540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO458_RS02545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FO458_RS02555	COG0629	single-stranded DNA binding
FO458_RS02565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FO458_RS02575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FO458_RS02580	COG0352	thiamine-phosphate diphosphorylase activity
FO458_RS02585	COG0706	membrane insertase activity
FO458_RS02590	COG1418	mRNA catabolic process
FO458_RS02595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO458_RS02600	COG1937	Protein conserved in bacteria
FO458_RS02615	COG0772	Belongs to the SEDS family
FO458_RS02620	COG1181	Belongs to the D-alanine--D-alanine ligase family
FO458_RS02625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FO458_RS02630	COG0513	Belongs to the DEAD box helicase family
FO458_RS02640	COG3428	Bacterial PH domain
FO458_RS02650	COG0736	holo-[acyl-carrier-protein] synthase activity
FO458_RS02665	COG2337	Toxic component of a toxin-antitoxin (TA) module
FO458_RS02670	COG2208	phosphoserine phosphatase activity
FO458_RS02685	COG1191	sigma factor activity
FO458_RS02690	COG2183	response to ionizing radiation
FO458_RS02730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FO458_RS02735	COG0066	3-isopropylmalate dehydratase activity
FO458_RS02740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FO458_RS02750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO458_RS02755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FO458_RS02765	COG0028	Belongs to the TPP enzyme family
FO458_RS02775	COG0802	atpase or kinase
FO458_RS02780	COG1214	PFAM Peptidase M22, glycoprotease
FO458_RS02785	COG0456	acetyltransferase
FO458_RS02790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FO458_RS02795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO458_RS02800	COG0488	(ABC) transporter
FO458_RS02805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FO458_RS02810	COG2391	methyltransferase activity
FO458_RS02815	COG0425	Belongs to the sulfur carrier protein TusA family
FO458_RS02820	COG0004	ammonium transporteR
FO458_RS02825	COG1609	Transcriptional regulator
FO458_RS02830	COG1621	beta-fructofuranosidase activity
FO458_RS02835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO458_RS02845	COG3290	protein histidine kinase activity
FO458_RS02855	COG4512	PFAM Accessory gene regulator B
FO458_RS02860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FO458_RS02885	COG0459	protein refolding
FO458_RS02890	COG0582	viral genome integration into host DNA
FO458_RS02895	COG3620	sequence-specific DNA binding
FO458_RS03015	COG0436	Aminotransferase
FO458_RS03025	COG1725	Transcriptional regulator
FO458_RS03030	COG1129	ABC transporter
FO458_RS03030	COG0842	Transport permease protein
FO458_RS03040	COG1131	(ABC) transporter
FO458_RS03080	COG2706	6-phosphogluconolactonase activity
FO458_RS03085	COG1012	belongs to the aldehyde dehydrogenase family
FO458_RS03090	COG1227	inorganic diphosphatase activity
FO458_RS03095	COG1335	isochorismatase
FO458_RS03110	COG0077	Prephenate dehydratase
FO458_RS03120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FO458_RS03125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FO458_RS03130	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FO458_RS03140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FO458_RS03145	COG4496	protein, YerC YecD
FO458_RS03150	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FO458_RS03160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FO458_RS03165	COG4851	CamS sex pheromone cAM373 precursor
FO458_RS03175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FO458_RS03185	COG0154	amidase activity
FO458_RS03190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FO458_RS03195	COG1597	lipid kinase activity
FO458_RS03200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FO458_RS03225	COG1528	Iron-storage protein
FO458_RS03245	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO458_RS03250	COG4129	membrane
FO458_RS03255	COG0024	Methionine aminopeptidase
FO458_RS03280	COG1295	ribonuclease BN
FO458_RS03290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO458_RS03295	COG4840	Belongs to the UPF0435 family
FO458_RS03300	COG2309	aminopeptidase activity
FO458_RS03305	COG1607	acyl-coa hydrolase
FO458_RS03310	COG0535	radical SAM domain protein
FO458_RS03320	COG0693	protein deglycase activity
FO458_RS03325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO458_RS03330	COG2137	regulation of response to DNA damage stimulus
FO458_RS03340	COG1388	LysM domain
FO458_RS03340	COG1134	teichoic acid transport
FO458_RS03350	COG1988	membrane-bound metal-dependent
FO458_RS03355	COG1194	a g-specific adenine glycosylase
FO458_RS03360	COG3557	Belongs to the UPF0374 family
FO458_RS03370	COG4129	membrane
FO458_RS03375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO458_RS03380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FO458_RS03390	COG0735	belongs to the Fur family
FO458_RS03550	COG0765	amino acid transport
FO458_RS03555	COG1126	abc transporter atp-binding protein
FO458_RS03560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FO458_RS03570	COG0363	glucosamine-6-phosphate deaminase activity
FO458_RS03585	COG0114	fumarate hydratase activity
FO458_RS03590	COG0564	pseudouridine synthase activity
FO458_RS03595	COG4585	Histidine kinase
FO458_RS03595	COG2203	Gaf domain
FO458_RS03600	COG2197	response regulator
FO458_RS03615	COG3679	Belongs to the UPF0342 family
FO458_RS03620	COG0420	3'-5' exonuclease activity
FO458_RS03645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FO458_RS03660	COG0537	adenosine 5'-monophosphoramidase activity
FO458_RS03665	COG1131	(ABC) transporter
FO458_RS03670	COG4473	ABC transporter
FO458_RS03675	COG2329	Antibiotic biosynthesis monooxygenase
FO458_RS03680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FO458_RS03690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FO458_RS03695	COG3545	Serine hydrolase
FO458_RS03745	COG0318	PFAM AMP-dependent synthetase and ligase
FO458_RS03755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FO458_RS03770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FO458_RS03775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FO458_RS03785	COG0656	L-ascorbic acid biosynthetic process
FO458_RS03790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FO458_RS03805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FO458_RS03830	COG3266	domain, Protein
FO458_RS03830	COG5632	N-Acetylmuramoyl-L-alanine amidase
FO458_RS03830	COG4193	domain, Protein
FO458_RS03840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO458_RS03840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO458_RS03850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO458_RS03850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO458_RS03855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FO458_RS03860	COG0506	proline dehydrogenase activity
FO458_RS03865	COG2267	carboxylic ester hydrolase activity
FO458_RS03875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FO458_RS03880	COG1242	4 iron, 4 sulfur cluster binding
FO458_RS03885	COG2814	Major facilitator Superfamily
FO458_RS03890	COG0495	leucyl-tRNA aminoacylation
FO458_RS03900	COG2081	HI0933 family
FO458_RS03905	COG2244	polysaccharide biosynthetic process
FO458_RS03910	COG1187	pseudouridine synthase activity
FO458_RS03920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO458_RS03930	COG0510	thiamine kinase activity
FO458_RS03935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FO458_RS03940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO458_RS03945	COG5584	Small secreted protein
FO458_RS03950	COG1363	Peptidase, m42
FO458_RS03955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO458_RS03960	COG4848	Belongs to the UPF0354 family
FO458_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO458_RS03970	COG1674	ftsk spoiiie
FO458_RS03975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FO458_RS03980	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FO458_RS03990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FO458_RS03990	COG1605	Chorismate mutase
FO458_RS03995	COG1609	Transcriptional regulator
FO458_RS04010	COG0123	including yeast histone deacetylase and acetoin utilization protein
FO458_RS04015	COG0454	-acetyltransferase
FO458_RS04020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO458_RS04025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FO458_RS04035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FO458_RS04040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO458_RS04045	COG0204	Acyl-transferase
FO458_RS04050	COG1263	PTS System
FO458_RS04050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS04060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FO458_RS04065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FO458_RS04070	COG1764	response to oxidative stress
FO458_RS04075	COG0584	glycerophosphoryl diester phosphodiesterase
FO458_RS04080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FO458_RS04090	COG1956	GAF domain-containing protein
FO458_RS04095	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FO458_RS04100	COG1104	cysteine desulfurase activity
FO458_RS04105	COG0301	tRNA thio-modification
FO458_RS04110	COG0730	response to heat
FO458_RS04115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FO458_RS04120	COG0827	DNA restriction-modification system
FO458_RS04125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FO458_RS04130	COG0589	response to stress
FO458_RS04135	COG0686	Belongs to the AlaDH PNT family
FO458_RS04140	COG0006	proline dipeptidase activity
FO458_RS04145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FO458_RS04155	COG4109	DRTGG domain
FO458_RS04160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FO458_RS04165	COG0587	DNA-directed DNA polymerase activity
FO458_RS04170	COG0281	malic enzyme
FO458_RS04175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FO458_RS04180	COG0825	malonyl-CoA metabolic process
FO458_RS04185	COG0205	6-phosphofructokinase activity
FO458_RS04190	COG0469	pyruvate kinase activity
FO458_RS04195	COG1113	amino acid transport
FO458_RS04200	COG0372	Belongs to the citrate synthase family
FO458_RS04205	COG0538	isocitrate dehydrogenase activity
FO458_RS04210	COG0745	RESPONSE REGULATOR receiver
FO458_RS04215	COG5002	protein histidine kinase activity
FO458_RS04220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO458_RS04220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO458_RS04225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FO458_RS04230	COG0237	dephospho-CoA kinase activity
FO458_RS04235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FO458_RS04240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FO458_RS04245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FO458_RS04250	COG3611	Membrane attachment protein
FO458_RS04255	COG1484	DNA-dependent DNA replication
FO458_RS04265	COG0833	amino acid
FO458_RS04270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FO458_RS04275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FO458_RS04280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FO458_RS04285	COG4112	unkown
FO458_RS04295	COG0544	peptidyl-prolyl cis-trans isomerase activity
FO458_RS04300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FO458_RS04315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FO458_RS04320	COG0181	hydroxymethylbilane synthase activity
FO458_RS04335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO458_RS04345	COG2818	Glycosylase
FO458_RS04350	COG0525	valine-tRNA ligase activity
FO458_RS04355	COG0285	dihydrofolate synthase activity
FO458_RS04365	COG2003	Belongs to the UPF0758 family
FO458_RS04380	COG1792	Involved in formation and maintenance of cell shape
FO458_RS04390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FO458_RS04395	COG2868	ribosomal protein
FO458_RS04405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FO458_RS04410	COG4492	Belongs to the UPF0735 family
FO458_RS04415	COG0632	four-way junction helicase activity
FO458_RS04420	COG2255	four-way junction helicase activity
FO458_RS04425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FO458_RS04430	COG0343	queuine tRNA-ribosyltransferase activity
FO458_RS04435	COG1862	Preprotein translocase
FO458_RS04440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO458_RS04440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO458_RS04445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FO458_RS04445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FO458_RS04455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FO458_RS04460	COG1490	D-aminoacyl-tRNA deacylase activity
FO458_RS04465	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO458_RS04470	COG0124	histidyl-tRNA synthetase
FO458_RS04475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FO458_RS04485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FO458_RS04490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FO458_RS04495	COG1959	2 iron, 2 sulfur cluster binding
FO458_RS04505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO458_RS04510	COG1104	cysteine desulfurase activity
FO458_RS04515	COG0482	sulfurtransferase activity
FO458_RS04525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FO458_RS04530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FO458_RS04535	COG4472	Bacterial protein of unknown function (DUF965)
FO458_RS04540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FO458_RS04550	COG4122	O-methyltransferase activity
FO458_RS04555	COG0826	peptidase U32
FO458_RS04560	COG0826	peptidase U32
FO458_RS04565	COG0572	uridine kinase
FO458_RS04570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FO458_RS04575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO458_RS04580	COG1984	allophanate hydrolase subunit 2
FO458_RS04585	COG0511	ligase activity, forming carbon-carbon bonds
FO458_RS04590	COG0439	Biotin carboxylase
FO458_RS04605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FO458_RS04610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FO458_RS04615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FO458_RS04625	COG1534	Rna-binding protein
FO458_RS04630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FO458_RS04635	COG1713	HD superfamily hydrolase involved in NAD metabolism
FO458_RS04640	COG0799	negative regulation of ribosome biogenesis
FO458_RS04645	COG2226	methyltransferase
FO458_RS04655	COG2131	deaminase
FO458_RS04660	COG2333	competence protein COMEC
FO458_RS04660	COG0658	competence protein
FO458_RS04665	COG1466	dna polymerase III delta subunit
FO458_RS04670	COG0268	Binds directly to 16S ribosomal RNA
FO458_RS04675	COG0481	GTPase activity
FO458_RS04680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FO458_RS04690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FO458_RS04695	COG0443	Heat shock 70 kDa protein
FO458_RS04700	COG0484	heat shock protein binding
FO458_RS04705	COG2264	protein methyltransferase activity
FO458_RS04710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FO458_RS04715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO458_RS04725	COG1030	water channel activity
FO458_RS04730	COG4864	UPF0365 protein
FO458_RS04740	COG1702	phosphate starvation-inducible protein PhoH
FO458_RS04745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FO458_RS04750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FO458_RS04755	COG0295	cytidine deaminase activity
FO458_RS04760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FO458_RS04765	COG1381	Involved in DNA repair and RecF pathway recombination
FO458_RS04770	COG0423	glycine-tRNA ligase activity
FO458_RS04775	COG0517	IMP dehydrogenase activity
FO458_RS04780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO458_RS04795	COG2384	SAM-dependent methyltransferase
FO458_RS04805	COG0513	Belongs to the DEAD box helicase family
FO458_RS04810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FO458_RS04815	COG1121	(ABC) transporter
FO458_RS04820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO458_RS04830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FO458_RS04835	COG0768	penicillin binding
FO458_RS04840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO458_RS04845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FO458_RS04850	COG0705	Rhomboid family
FO458_RS04850	COG0457	Tetratricopeptide repeat
FO458_RS04855	COG4483	Protein conserved in bacteria
FO458_RS04860	COG1940	carbohydrate kinase activity
FO458_RS04865	COG0011	TIGRFAM Protein of
FO458_RS04870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO458_RS04875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FO458_RS04880	COG1459	type II secretion system
FO458_RS04885	COG4537	Required for transformation and DNA binding
FO458_RS04910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FO458_RS04915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FO458_RS04920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO458_RS04925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO458_RS04930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FO458_RS04935	COG0095	Lipoate-protein ligase
FO458_RS04950	COG0006	proline dipeptidase activity
FO458_RS04955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FO458_RS04960	COG0511	ligase activity, forming carbon-carbon bonds
FO458_RS04965	COG0439	Biotin carboxylase
FO458_RS04970	COG1302	Protein conserved in bacteria
FO458_RS04975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO458_RS04995	COG1438	arginine binding
FO458_RS05000	COG0497	DNA recombination
FO458_RS05005	COG0280	phosphate acetyltransferase
FO458_RS05010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO458_RS05015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO458_RS05020	COG0022	dehydrogenase e1 component
FO458_RS05025	COG0508	dehydrogenase complex catalyzes the overall conversion of
FO458_RS05035	COG4129	membrane
FO458_RS05045	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO458_RS05055	COG1609	Transcriptional regulator
FO458_RS05060	COG0366	Alpha amylase catalytic
FO458_RS05070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FO458_RS05080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FO458_RS05085	COG0300	oxidoreductase activity
FO458_RS05090	COG0667	Aldo Keto reductase
FO458_RS05095	COG0494	nUDIX hydrolase
FO458_RS05100	COG0735	belongs to the Fur family
FO458_RS05105	COG4974	Belongs to the 'phage' integrase family
FO458_RS05115	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FO458_RS05120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FO458_RS05125	COG1187	pseudouridine synthase activity
FO458_RS05130	COG0745	RESPONSE REGULATOR receiver
FO458_RS05145	COG1141	Ferredoxin
FO458_RS05155	COG0514	ATP-dependent DNA helicase (RecQ)
FO458_RS05160	COG1388	LysM domain
FO458_RS05165	COG0492	ferredoxin-NADP+ reductase activity
FO458_RS05185	COG0539	negative regulation of cytoplasmic translation
FO458_RS05195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FO458_RS05210	COG2226	methyltransferase
FO458_RS05215	COG0142	geranyltranstransferase activity
FO458_RS05225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FO458_RS05230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FO458_RS05255	COG2738	Putative neutral zinc metallopeptidase
FO458_RS05260	COG1694	Mazg nucleotide pyrophosphohydrolase
FO458_RS05265	COG0438	transferase activity, transferring glycosyl groups
FO458_RS05270	COG0617	tRNA 3'-terminal CCA addition
FO458_RS05275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FO458_RS05275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FO458_RS05280	COG1199	ATP-dependent helicase activity
FO458_RS05280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FO458_RS05285	COG0017	Asparaginyl-tRNA synthetase
FO458_RS05290	COG3935	DnaD domain protein
FO458_RS05295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FO458_RS05305	COG4499	WXG100 protein secretion system (Wss), protein YukC
FO458_RS05305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO458_RS05320	COG4474	Belongs to the UPF0398 family
FO458_RS05325	COG3599	regulation of cell shape
FO458_RS05335	COG0116	Belongs to the methyltransferase superfamily
FO458_RS05345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FO458_RS05350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO458_RS05355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO458_RS05360	COG0512	Glutamine amidotransferase of anthranilate synthase
FO458_RS05365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO458_RS05370	COG0134	indole-3-glycerol-phosphate synthase activity
FO458_RS05375	COG0135	phosphoribosylanthranilate isomerase activity
FO458_RS05390	COG2348	transferase activity, transferring amino-acyl groups
FO458_RS05400	COG0561	phosphatase activity
FO458_RS05405	COG4607	ABC-type enterochelin transport system periplasmic component
FO458_RS05415	COG1164	Oligoendopeptidase f
FO458_RS05425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FO458_RS05430	COG0581	inorganic phosphate transmembrane transporter activity
FO458_RS05435	COG0573	inorganic phosphate transmembrane transporter activity
FO458_RS05440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FO458_RS05445	COG2996	Protein conserved in bacteria
FO458_RS05450	COG0488	(ABC) transporter
FO458_RS05455	COG0527	aspartate kinase activity
FO458_RS05460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FO458_RS05465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO458_RS05470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FO458_RS05475	COG2171	N-acyltransferase activity
FO458_RS05480	COG1473	amidohydrolase
FO458_RS05505	COG1278	Cold shock
FO458_RS05515	COG1254	Belongs to the acylphosphatase family
FO458_RS05525	COG3853	Toxic anion resistance protein (TelA)
FO458_RS05530	COG1114	Component of the transport system for branched-chain amino acids
FO458_RS05535	COG4548	von Willebrand factor, type A
FO458_RS05540	COG0714	Associated with various cellular activities
FO458_RS05560	COG0567	Dehydrogenase, E1 component
FO458_RS05565	COG5002	protein histidine kinase activity
FO458_RS05570	COG0745	RESPONSE REGULATOR receiver
FO458_RS05575	COG0671	phosphoesterase, PA-phosphatase related
FO458_RS05580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO458_RS05590	COG0793	Belongs to the peptidase S41A family
FO458_RS05595	COG4479	Belongs to the UPF0346 family
FO458_RS05605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO458_RS05635	COG1413	lyase activity
FO458_RS05645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FO458_RS05650	COG0328	RNA-DNA hybrid ribonuclease activity
FO458_RS05655	COG1363	Peptidase, m42
FO458_RS05670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS05680	COG3623	hexulose-6-phosphate isomerase
FO458_RS05700	COG0287	Prephenate dehydrogenase
FO458_RS05705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FO458_RS05710	COG1942	4-Oxalocrotonate Tautomerase
FO458_RS05740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FO458_RS05740	COG0392	lysyltransferase activity
FO458_RS05745	COG0628	permease
FO458_RS05750	COG1115	amino acid carrier protein
FO458_RS05755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO458_RS05760	COG0187	DNA topoisomerase II activity
FO458_RS05765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FO458_RS05770	COG4841	protein insertion into membrane
FO458_RS05775	COG0824	Thioesterase
FO458_RS05780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FO458_RS05785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO458_RS05790	COG1970	mechanosensitive ion channel activity
FO458_RS05805	COG4846	Membrane protein involved in cytochrome C biogenesis
FO458_RS05810	COG3763	UPF0154 protein
FO458_RS05815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FO458_RS05820	COG4224	UPF0291 protein
FO458_RS05830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO458_RS05840	COG2340	Cysteine-rich secretory protein family
FO458_RS05850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FO458_RS05865	COG0833	amino acid
FO458_RS05880	COG0083	homoserine kinase activity
FO458_RS05885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FO458_RS05890	COG0460	homoserine dehydrogenase
FO458_RS05895	COG0527	aspartate kinase activity
FO458_RS05910	COG1525	nuclease
FO458_RS05925	COG2197	response regulator
FO458_RS05930	COG4585	Histidine kinase
FO458_RS05930	COG2203	Gaf domain
FO458_RS05940	COG1131	(ABC) transporter
FO458_RS05945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO458_RS05960	COG0789	Transcriptional regulator
FO458_RS05965	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FO458_RS05970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FO458_RS05980	COG1923	regulation of RNA biosynthetic process
FO458_RS05985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FO458_RS05995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FO458_RS06000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FO458_RS06005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FO458_RS06015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FO458_RS06020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO458_RS06035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO458_RS06050	COG4195	phage-related replication protein
FO458_RS06055	COG1013	pyruvate-flavodoxin oxidoreductase activity
FO458_RS06060	COG0674	pyruvate-flavodoxin oxidoreductase activity
FO458_RS06060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FO458_RS06065	COG1692	metallophosphoesterase
FO458_RS06075	COG1418	mRNA catabolic process
FO458_RS06080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FO458_RS06085	COG1546	Belongs to the CinA family
FO458_RS06085	COG1058	Belongs to the CinA family
FO458_RS06105	COG0300	oxidoreductase activity
FO458_RS06110	COG0612	Peptidase, M16
FO458_RS06115	COG0612	Peptidase, M16
FO458_RS06120	COG2188	Transcriptional regulator
FO458_RS06125	COG1674	ftsk spoiiie
FO458_RS06130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO458_RS06135	COG1185	polyribonucleotide nucleotidyltransferase activity
FO458_RS06145	COG0196	riboflavin kinase activity
FO458_RS06155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FO458_RS06160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FO458_RS06165	COG1358	cellular component organization or biogenesis
FO458_RS06170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FO458_RS06175	COG0195	Participates in both transcription termination and antitermination
FO458_RS06180	COG0779	Required for maturation of 30S ribosomal subunits
FO458_RS06185	COG2176	DNA-directed DNA polymerase activity
FO458_RS06190	COG0442	prolyl-tRNA aminoacylation
FO458_RS06205	COG4589	Belongs to the CDS family
FO458_RS06210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FO458_RS06215	COG0233	cytoplasmic translational termination
FO458_RS06220	COG0528	UMP kinase activity
FO458_RS06225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FO458_RS06230	COG0052	Belongs to the universal ribosomal protein uS2 family
FO458_RS06235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FO458_RS06240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FO458_RS06245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FO458_RS06250	COG4974	Belongs to the 'phage' integrase family
FO458_RS06255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FO458_RS06260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FO458_RS06265	COG0758	DNA mediated transformation
FO458_RS06270	COG2348	transferase activity, transferring amino-acyl groups
FO458_RS06280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FO458_RS06285	COG0045	succinate-CoA ligase (ADP-forming) activity
FO458_RS06290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO458_RS06300	COG4485	Bacterial membrane protein, YfhO
FO458_RS06310	COG0335	large ribosomal subunit rRNA binding
FO458_RS06315	COG0336	Belongs to the RNA methyltransferase TrmD family
FO458_RS06320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FO458_RS06325	COG0228	four-way junction DNA binding
FO458_RS06340	COG0183	Belongs to the thiolase family
FO458_RS06345	COG0318	PFAM AMP-dependent synthetase and ligase
FO458_RS06350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FO458_RS06355	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FO458_RS06360	COG0552	protein localization to endoplasmic reticulum
FO458_RS06365	COG1196	nuclear chromosome segregation
FO458_RS06370	COG0571	ribonuclease III activity
FO458_RS06375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO458_RS06390	COG0416	fatty acid biosynthetic process
FO458_RS06395	COG1349	DNA-binding transcription factor activity
FO458_RS06400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FO458_RS06405	COG1461	Dihydroxyacetone kinase
FO458_RS06410	COG1302	Protein conserved in bacteria
FO458_RS06415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FO458_RS06425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FO458_RS06440	COG0631	protein serine/threonine phosphatase activity
FO458_RS06450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO458_RS06450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FO458_RS06455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FO458_RS06465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FO458_RS06470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FO458_RS06475	COG1758	RNA polymerase activity
FO458_RS06480	COG0194	GDP metabolic process
FO458_RS06500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FO458_RS06505	COG0284	orotidine-5'-phosphate decarboxylase activity
FO458_RS06515	COG0505	Belongs to the CarA family
FO458_RS06525	COG0540	Belongs to the ATCase OTCase family
FO458_RS06530	COG2233	PERMEase
FO458_RS06535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FO458_RS06540	COG0564	pseudouridine synthase activity
FO458_RS06545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FO458_RS06555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FO458_RS06560	COG3599	regulation of cell shape
FO458_RS06565	COG2302	S4 RNA-binding domain
FO458_RS06570	COG0762	integral membrane protein
FO458_RS06575	COG1799	cell septum assembly
FO458_RS06580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FO458_RS06585	COG1496	oxidoreductase activity
FO458_RS06590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FO458_RS06595	COG0849	cell division
FO458_RS06600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FO458_RS06605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO458_RS06610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO458_RS06615	COG0768	penicillin binding
FO458_RS06620	COG4839	cell division protein FtsL
FO458_RS06625	COG0275	rRNA processing
FO458_RS06635	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FO458_RS06640	COG0454	-acetyltransferase
FO458_RS06650	COG1011	Hydrolase
FO458_RS06660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FO458_RS06665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FO458_RS06670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FO458_RS06675	COG1053	succinate dehydrogenase
FO458_RS06680	COG2009	succinate dehydrogenase
FO458_RS06685	COG0322	excinuclease ABC activity
FO458_RS06690	COG3118	belongs to the thioredoxin family
FO458_RS06695	COG1193	negative regulation of DNA recombination
FO458_RS06700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FO458_RS06700	COG1796	DNA polymerase
FO458_RS06710	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FO458_RS06715	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO458_RS06720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO458_RS06720	COG0072	phenylalanine-tRNA ligase activity
FO458_RS06725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FO458_RS06730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO458_RS06735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FO458_RS06750	COG1323	Belongs to the UPF0348 family
FO458_RS06755	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FO458_RS06760	COG0742	ribosomal rna small subunit methyltransferase
FO458_RS06775	COG0584	glycerophosphoryl diester phosphodiesterase
FO458_RS06780	COG3679	Belongs to the UPF0342 family
FO458_RS06795	COG0109	protoheme IX farnesyltransferase activity
FO458_RS06800	COG1612	heme a metabolic process
FO458_RS06815	COG0772	Belongs to the SEDS family
FO458_RS06820	COG4838	Belongs to the UPF0358 family
FO458_RS06825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FO458_RS06835	COG1217	gtp-binding protein TYPA
FO458_RS06845	COG0483	inositol monophosphate 1-phosphatase activity
FO458_RS06850	COG4493	Belongs to the UPF0637 family
FO458_RS06870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FO458_RS06875	COG1177	transmembrane transport
FO458_RS06895	COG4476	Belongs to the UPF0223 family
FO458_RS06910	COG0022	dehydrogenase e1 component
FO458_RS06925	COG0242	peptide deformylase activity
FO458_RS06930	COG5503	Protein of unknown function (DUF1447)
FO458_RS06935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO458_RS06945	COG0569	domain protein
FO458_RS06960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO458_RS06975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FO458_RS06990	COG4172	Belongs to the ABC transporter superfamily
FO458_RS06995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FO458_RS07000	COG0151	Belongs to the GarS family
FO458_RS07005	COG0138	bifunctional purine biosynthesis protein purh
FO458_RS07015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FO458_RS07025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO458_RS07030	COG0047	phosphoribosylformylglycinamidine synthase activity
FO458_RS07035	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO458_RS07040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FO458_RS07045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FO458_RS07050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FO458_RS07055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FO458_RS07065	COG1017	nitric oxide dioxygenase activity
FO458_RS07065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FO458_RS07075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FO458_RS07085	COG1845	cytochrome c oxidase, subunit III
FO458_RS07090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FO458_RS07100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FO458_RS07105	COG1316	TRANSCRIPTIONal
FO458_RS07135	COG3594	Acyltransferase
FO458_RS07140	COG0436	Aminotransferase
FO458_RS07145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FO458_RS07150	COG0596	Alpha beta hydrolase
FO458_RS07155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FO458_RS07160	COG1169	isochorismate synthase
FO458_RS07165	COG1575	Belongs to the MenA family. Type 1 subfamily
FO458_RS07220	COG4873	Protein conserved in bacteria
FO458_RS07230	COG0737	Belongs to the 5'-nucleotidase family
FO458_RS07235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FO458_RS07240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO458_RS07245	COG0861	Integral membrane protein TerC family
FO458_RS07260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FO458_RS07265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO458_RS07270	COG2814	Major facilitator Superfamily
FO458_RS07275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FO458_RS07280	COG0789	Transcriptional regulator
FO458_RS07285	COG4221	oxidoreductase activity
FO458_RS07295	COG0628	permease
FO458_RS07305	COG0475	glutathione-regulated potassium exporter activity
FO458_RS07305	COG0569	domain protein
FO458_RS07310	COG2239	Acts as a magnesium transporter
FO458_RS07315	COG0564	pseudouridine synthase activity
FO458_RS07325	COG2357	RelA SpoT domain protein
FO458_RS07340	COG2346	COG2346, Truncated hemoglobins
FO458_RS07345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FO458_RS07350	COG1164	Oligoendopeptidase f
FO458_RS07365	COG1393	Belongs to the ArsC family
FO458_RS07370	COG0180	Tryptophanyl-tRNA synthetase
FO458_RS07375	COG2226	methyltransferase
FO458_RS07380	COG4166	transmembrane transport
FO458_RS07385	COG4608	Belongs to the ABC transporter superfamily
FO458_RS07395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FO458_RS07400	COG0601	transmembrane transport
FO458_RS07415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FO458_RS07435	COG0561	phosphatase activity
FO458_RS07440	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO458_RS07455	COG1074	ATP-dependent DNA helicase activity
FO458_RS07475	COG0398	Pfam SNARE associated Golgi protein
FO458_RS07480	COG0166	Belongs to the GPI family
FO458_RS07485	COG0137	argininosuccinate synthase activity
FO458_RS07515	COG1902	pentaerythritol trinitrate reductase activity
FO458_RS07520	COG1098	S1 RNA binding domain
FO458_RS07525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FO458_RS07535	COG2111	Na H antiporter
FO458_RS07535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO458_RS07540	COG2111	Na H antiporter
FO458_RS07545	COG1006	Multisubunit Na H antiporter MnhC subunit
FO458_RS07550	COG0651	ATP synthesis coupled electron transport
FO458_RS07555	COG1863	multisubunit Na H antiporter MnhE subunit
FO458_RS07560	COG2212	antiporter activity
FO458_RS07565	COG1320	monovalent cation:proton antiporter activity
FO458_RS07575	COG2050	protein possibly involved in aromatic compounds catabolism
FO458_RS07580	COG2056	Na+-H+ antiporter family
FO458_RS07585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FO458_RS07590	COG1252	NADH dehydrogenase
FO458_RS07600	COG1132	(ABC) transporter
FO458_RS07610	COG1129	ABC transporter
FO458_RS07640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO458_RS07640	COG2226	methyltransferase
FO458_RS07640	COG3433	isochorismatase activity
FO458_RS07645	COG1021	2,3-dihydroxybenzoate-AMP ligase
FO458_RS07660	COG0316	Belongs to the HesB IscA family
FO458_RS07665	COG4844	belongs to the
FO458_RS07670	COG1252	NADH dehydrogenase
FO458_RS07675	COG4837	Protein of unknown function (DUF1462)
FO458_RS07680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FO458_RS07685	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FO458_RS07690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO458_RS07695	COG1696	Membrane protein involved in D-alanine export
FO458_RS07700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO458_RS07710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO458_RS07715	COG0647	UMP catabolic process
FO458_RS07720	COG2445	Protein of unknown function DUF86
FO458_RS07730	COG4470	Protein conserved in bacteria
FO458_RS07735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FO458_RS07740	COG0737	Belongs to the 5'-nucleotidase family
FO458_RS07745	COG0730	response to heat
FO458_RS07750	COG1801	Protein of unknown function DUF72
FO458_RS07755	COG2070	2-Nitropropane dioxygenase
FO458_RS07760	COG1253	flavin adenine dinucleotide binding
FO458_RS07885	COG3942	CHAP domain
FO458_RS07885	COG1388	LysM domain
FO458_RS07910	COG0719	Fe-S assembly protein
FO458_RS07915	COG0822	iron-sulfur transferase activity
FO458_RS07925	COG0719	Fe-S assembly protein
FO458_RS07930	COG0396	ATPase activity
FO458_RS07950	COG1464	Belongs to the NlpA lipoprotein family
FO458_RS07955	COG2011	ABC-type metal ion transport system permease component
FO458_RS07960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO458_RS07970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO458_RS07975	COG0509	glycine decarboxylation via glycine cleavage system
FO458_RS07980	COG1393	Belongs to the ArsC family
FO458_RS07985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO458_RS07995	COG0710	3-dehydroquinate dehydratase activity
FO458_RS08000	COG1764	response to oxidative stress
FO458_RS08010	COG0588	phosphoglycerate mutase activity
FO458_RS08040	COG4195	phage-related replication protein
FO458_RS08055	COG2259	Doxx family
FO458_RS08060	COG0346	lactoylglutathione lyase activity
FO458_RS08070	COG1611	Belongs to the LOG family
FO458_RS08175	COG0557	exoribonuclease II activity
FO458_RS08180	COG1647	Serine aminopeptidase, S33
FO458_RS08185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO458_RS08195	COG0148	phosphopyruvate hydratase activity
FO458_RS08200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FO458_RS08205	COG0149	triose-phosphate isomerase activity
FO458_RS08210	COG0126	phosphoglycerate kinase activity
FO458_RS08230	COG1090	epimerase
FO458_RS08235	COG0740	serine-type endopeptidase activity
FO458_RS08240	COG1481	regulation of sporulation
FO458_RS08245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FO458_RS08250	COG1660	Displays ATPase and GTPase activities
FO458_RS08255	COG0492	ferredoxin-NADP+ reductase activity
FO458_RS08270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FO458_RS08275	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FO458_RS08280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FO458_RS08300	COG1388	LysM domain
FO458_RS08300	COG3942	CHAP domain
FO458_RS08310	COG0653	protein targeting
FO458_RS08320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FO458_RS08325	COG1040	competence protein
FO458_RS08340	COG1739	Uncharacterized protein family UPF0029
FO458_RS08345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO458_RS08350	COG2199	diguanylate cyclase activity
FO458_RS08365	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO458_RS08370	COG1929	Belongs to the glycerate kinase type-1 family
FO458_RS08390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FO458_RS08400	COG4607	ABC-type enterochelin transport system periplasmic component
FO458_RS08410	COG4605	iron ion homeostasis
FO458_RS08415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS08420	COG4607	ABC-type enterochelin transport system periplasmic component
FO458_RS08425	COG4604	ABC transporter, ATP-binding protein
FO458_RS08430	COG4605	iron ion homeostasis
FO458_RS08435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS08440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO458_RS08445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO458_RS08450	COG1780	Probably involved in ribonucleotide reductase function
FO458_RS08460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FO458_RS08465	COG3104	oligopeptide transport
FO458_RS08470	COG1597	lipid kinase activity
FO458_RS08480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FO458_RS08485	COG3104	oligopeptide transport
FO458_RS08490	COG1174	glycine betaine transport
FO458_RS08500	COG0514	ATP-dependent DNA helicase (RecQ)
FO458_RS08505	COG0488	(ABC) transporter
FO458_RS08515	COG1368	sulfuric ester hydrolase activity
FO458_RS08525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO458_RS08535	COG0512	Glutamine amidotransferase of anthranilate synthase
FO458_RS08535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO458_RS08540	COG0512	Glutamine amidotransferase of anthranilate synthase
FO458_RS08540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO458_RS08550	COG0720	synthase
FO458_RS08565	COG0463	Glycosyl transferase, family 2
FO458_RS08570	COG0656	L-ascorbic acid biosynthetic process
FO458_RS08575	COG1253	flavin adenine dinucleotide binding
FO458_RS08580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO458_RS08580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO458_RS08580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS08585	COG1105	Belongs to the carbohydrate kinase PfkB family
FO458_RS08590	COG1349	DNA-binding transcription factor activity
FO458_RS08595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FO458_RS08625	COG0415	Belongs to the DNA photolyase family
FO458_RS08630	COG0471	metal ion transport
FO458_RS08635	COG0039	L-malate dehydrogenase activity
FO458_RS08650	COG0523	cobalamin synthesis protein
FO458_RS08660	COG1968	undecaprenyl-diphosphatase activity
FO458_RS08670	COG1671	Belongs to the UPF0178 family
FO458_RS08675	COG1611	Belongs to the LOG family
FO458_RS08700	COG2839	Protein conserved in bacteria
FO458_RS08705	COG2814	Major facilitator Superfamily
FO458_RS08710	COG0583	DNA-binding transcription factor activity
FO458_RS08725	COG0217	transcriptional regulatory protein
FO458_RS08745	COG1388	LysM domain
FO458_RS08745	COG3942	CHAP domain
FO458_RS08750	COG0306	phosphate transporter
FO458_RS08755	COG1392	Phosphate transport regulator
FO458_RS08760	COG0577	efflux transmembrane transporter activity
FO458_RS08765	COG1136	(ABC) transporter
FO458_RS08770	COG2205	protein histidine kinase activity
FO458_RS08775	COG0745	RESPONSE REGULATOR receiver
FO458_RS08780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO458_RS08790	COG0657	acetylesterase activity
FO458_RS08795	COG3949	Membrane
FO458_RS08805	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FO458_RS08810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS08815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS08820	COG1120	ATPase activity
FO458_RS08825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FO458_RS08835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO458_RS08845	COG0463	Glycosyl transferase, family 2
FO458_RS08845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS08850	COG0438	transferase activity, transferring glycosyl groups
FO458_RS08855	COG1132	(ABC) transporter
FO458_RS08860	COG1686	Belongs to the peptidase S11 family
FO458_RS08865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FO458_RS08870	COG1216	Glycosyl transferase, family 2
FO458_RS08870	COG1442	glycosyl transferase family 8
FO458_RS08875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS08880	COG1682	transport, permease protein
FO458_RS08885	COG1134	teichoic acid transport
FO458_RS08900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FO458_RS08910	COG1321	iron dependent repressor
FO458_RS08915	COG1121	(ABC) transporter
FO458_RS08920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO458_RS08925	COG0803	Belongs to the bacterial solute-binding protein 9 family
FO458_RS08935	COG1320	monovalent cation:proton antiporter activity
FO458_RS08940	COG2212	antiporter activity
FO458_RS08945	COG1863	multisubunit Na H antiporter MnhE subunit
FO458_RS08950	COG0651	ATP synthesis coupled electron transport
FO458_RS08955	COG1006	Multisubunit Na H antiporter MnhC subunit
FO458_RS08960	COG2111	Na H antiporter
FO458_RS08965	COG2111	Na H antiporter
FO458_RS08965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO458_RS08970	COG4974	Belongs to the 'phage' integrase family
FO458_RS09000	COG0596	Alpha beta hydrolase
FO458_RS09025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS09030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO458_RS09050	COG0018	arginyl-trna synthetase
FO458_RS09070	COG1064	alcohol dehydrogenase
FO458_RS09080	COG1078	dGTPase activity
FO458_RS09090	COG0655	NAD(P)H dehydrogenase (quinone) activity
FO458_RS09095	COG0667	Aldo Keto reductase
FO458_RS09105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO458_RS09120	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO458_RS09120	COG1388	LysM domain
FO458_RS09295	COG1484	DNA-dependent DNA replication
FO458_RS09365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO458_RS09380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO458_RS09385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO458_RS09390	COG4844	belongs to the
FO458_RS09410	COG0095	Lipoate-protein ligase
FO458_RS09420	COG3253	May function as heme-dependent peroxidase
FO458_RS09450	COG0531	amino acid
FO458_RS09455	COG2363	Small membrane protein
FO458_RS09465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FO458_RS09500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FO458_RS09505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FO458_RS09515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FO458_RS09525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS09550	COG0561	phosphatase activity
FO458_RS09560	COG1428	Deoxynucleoside kinase
FO458_RS09565	COG1428	Deoxynucleoside kinase
FO458_RS09585	COG0531	amino acid
FO458_RS09590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FO458_RS09600	COG1279	arginine transmembrane transporter activity
FO458_RS09625	COG1473	amidohydrolase
FO458_RS09630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FO458_RS09645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FO458_RS09655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FO458_RS09660	COG0085	RNA polymerase activity
FO458_RS09665	COG2813	Specifically methylates the guanine in position
FO458_RS09670	COG0222	ribosome binding
FO458_RS09675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FO458_RS09685	COG0081	regulation of translation
FO458_RS09695	COG0250	Participates in transcription elongation, termination and antitermination
FO458_RS09700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO458_RS09705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO458_RS09715	COG3688	RNA-binding protein containing a PIN domain
FO458_RS09720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO458_RS09725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FO458_RS09730	COG0215	cysteine-tRNA ligase activity
FO458_RS09735	COG1045	serine acetyltransferase
FO458_RS09740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FO458_RS09745	COG4956	integral membrane protein (PIN domain superfamily)
FO458_RS09750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FO458_RS09755	COG0542	response to heat
FO458_RS09760	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FO458_RS09765	COG3880	PFAM UvrB UvrC protein
FO458_RS09770	COG4463	regulation of RNA biosynthetic process
FO458_RS09775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO458_RS09780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FO458_RS09785	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FO458_RS09790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FO458_RS09860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FO458_RS09870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FO458_RS09875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FO458_RS09885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO458_RS09895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FO458_RS09910	COG1098	S1 RNA binding domain
FO458_RS09920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FO458_RS09925	COG3956	TIGRFAM MazG family protein
FO458_RS09930	COG2244	polysaccharide biosynthetic process
FO458_RS09935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FO458_RS09940	COG0193	aminoacyl-tRNA hydrolase activity
FO458_RS09950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FO458_RS09955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FO458_RS09965	COG0251	oxidation-reduction process
FO458_RS09970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO458_RS09975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FO458_RS09980	COG4466	Protein conserved in bacteria
FO458_RS09985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FO458_RS09990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO458_RS09995	COG0084	hydrolase, TatD family'
FO458_RS10000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO458_RS10000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO458_RS10005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FO458_RS10015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FO458_RS10025	COG1774	PSP1 C-terminal conserved region
FO458_RS10030	COG0470	DNA polymerase III
FO458_RS10035	COG3870	Protein conserved in bacteria
FO458_RS10040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FO458_RS10045	COG1982	Orn Lys Arg decarboxylase major
FO458_RS10080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FO458_RS10090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FO458_RS10105	COG2188	Transcriptional regulator
FO458_RS10110	COG0366	Alpha amylase catalytic
FO458_RS10115	COG1263	PTS System
FO458_RS10115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS10125	COG0493	'glutamate synthase
FO458_RS10130	COG0067	glutamate synthase
FO458_RS10130	COG0069	glutamate synthase activity
FO458_RS10130	COG0070	glutamate synthase
FO458_RS10135	COG0583	DNA-binding transcription factor activity
FO458_RS10165	COG1464	Belongs to the NlpA lipoprotein family
FO458_RS10170	COG2011	ABC-type metal ion transport system permease component
FO458_RS10175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO458_RS10180	COG1132	(ABC) transporter
FO458_RS10185	COG1132	(ABC) transporter
FO458_RS10185	COG2375	cellular response to nickel ion
FO458_RS10190	COG0626	cystathionine gamma-synthase activity
FO458_RS10195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO458_RS10205	COG0733	neurotransmitter:sodium symporter activity
FO458_RS10225	COG5609	conserved protein (DUF2294)
FO458_RS10230	COG3002	Belongs to the UPF0753 family
FO458_RS10235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO458_RS10245	COG0523	cobalamin synthesis protein
FO458_RS10265	COG0519	Catalyzes the synthesis of GMP from XMP
FO458_RS10265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FO458_RS10270	COG0517	IMP dehydrogenase activity
FO458_RS10270	COG0516	GMP reductase activity
FO458_RS10275	COG2233	PERMEase
FO458_RS10280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO458_RS10300	COG1823	symporter activity
FO458_RS10305	COG0778	Nitroreductase
FO458_RS10315	COG0450	alkyl hydroperoxide reductase
FO458_RS10320	COG3634	alkyl hydroperoxide reductase activity
FO458_RS10335	COG0588	phosphoglycerate mutase activity
FO458_RS10410	COG1683	Conserved Protein
FO458_RS10415	COG3728	DNA packaging
FO458_RS10415	COG5484	DNA packaging
FO458_RS10495	COG0582	viral genome integration into host DNA
FO458_RS10500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FO458_RS10510	COG0360	Binds together with S18 to 16S ribosomal RNA
FO458_RS10525	COG0012	GTP binding
FO458_RS10530	COG4481	Protein conserved in bacteria
FO458_RS10535	COG0668	transmembrane transport
FO458_RS10540	COG1475	DNA binding
FO458_RS10545	COG0626	cystathionine gamma-synthase activity
FO458_RS10550	COG0626	cystathionine gamma-synthase activity
FO458_RS10555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FO458_RS10555	COG0646	methionine synthase
FO458_RS10560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FO458_RS10585	COG0577	efflux transmembrane transporter activity
FO458_RS10590	COG1136	(ABC) transporter
FO458_RS10610	COG2205	protein histidine kinase activity
FO458_RS10625	COG0745	RESPONSE REGULATOR receiver
FO458_RS10655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FO458_RS10660	COG2271	Major facilitator Superfamily
FO458_RS10675	COG1136	(ABC) transporter
FO458_RS10680	COG0577	efflux transmembrane transporter activity
FO458_RS10690	COG1396	sequence-specific DNA binding
FO458_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS10715	COG1063	alcohol dehydrogenase
FO458_RS10735	COG1475	DNA binding
FO458_RS10745	COG0445	tRNA wobble uridine modification
FO458_RS10750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FO458_RS10755	COG0594	ribonuclease P activity
FO458_RS10765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FO458_RS10770	COG0592	DNA-directed DNA polymerase activity
FO458_RS10775	COG2501	S4 domain
FO458_RS10780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FO458_RS10785	COG0187	DNA topoisomerase II activity
FO458_RS10790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO458_RS10795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FO458_RS10805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FO458_RS10815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FO458_RS10825	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FO458_RS10830	COG0359	binds to the 23S rRNA
FO458_RS10835	COG0305	Participates in initiation and elongation during chromosome replication
FO458_RS10840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FO458_RS10855	COG0745	RESPONSE REGULATOR receiver
FO458_RS10860	COG5002	protein histidine kinase activity
FO458_RS10865	COG4863	YycH protein
FO458_RS10900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FO458_RS10905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FO458_RS10915	COG1522	sequence-specific DNA binding
FO458_RS10945	COG1073	alpha beta
FO458_RS10975	COG1129	ABC transporter
FO458_RS11015	COG0745	RESPONSE REGULATOR receiver
FO458_RS11030	COG1131	(ABC) transporter
FO458_RS11090	COG2188	Transcriptional regulator
FO458_RS11095	COG2222	sugar isomerase
FO458_RS11105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS11110	COG3715	PTS system
FO458_RS11115	COG3716	PTS system mannose fructose sorbose family IID component
FO458_RS11125	COG0745	RESPONSE REGULATOR receiver
FO458_RS11130	COG2205	protein histidine kinase activity
FO458_RS11140	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FO458_RS11145	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FO458_RS11170	COG1129	ABC transporter
FO458_RS11205	COG4509	Sortase family
FO458_RS11215	COG3942	CHAP domain
FO458_RS11215	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO458_RS11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS11225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO458_RS11230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO458_RS11235	COG2808	Putative FMN-binding domain
FO458_RS11245	COG1846	Transcriptional regulator
FO458_RS11260	COG3842	ATPase activity
FO458_RS11265	COG4209	transmembrane transport
FO458_RS11275	COG0395	ABC-type sugar transport system, permease component
FO458_RS11285	COG0534	Mate efflux family protein
FO458_RS11290	COG1349	DNA-binding transcription factor activity
FO458_RS11300	COG5002	protein histidine kinase activity
FO458_RS11335	COG0583	DNA-binding transcription factor activity
FO458_RS11340	COG3842	ATPase activity
FO458_RS11345	COG1840	ABC-type Fe3 transport system, periplasmic component
FO458_RS11350	COG1177	transmembrane transport
FO458_RS11355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FO458_RS11360	COG1414	Transcriptional regulator
FO458_RS11370	COG0800	Aldolase
FO458_RS11375	COG4948	Mandelate Racemase Muconate Lactonizing
FO458_RS11380	COG2610	gluconate transmembrane transporter activity
FO458_RS11395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FO458_RS11405	COG1114	Component of the transport system for branched-chain amino acids
FO458_RS11415	COG0464	growth
FO458_RS11420	COG0561	phosphatase activity
FO458_RS11425	COG2814	Major facilitator Superfamily
FO458_RS11440	COG0601	transmembrane transport
FO458_RS11450	COG0444	Belongs to the ABC transporter superfamily
FO458_RS11455	COG1124	(ABC) transporter
FO458_RS11470	COG0693	protein deglycase activity
FO458_RS11475	COG0531	amino acid
FO458_RS11480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO458_RS11480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO458_RS11485	COG0505	Belongs to the CarA family
FO458_RS11490	COG0657	acetylesterase activity
FO458_RS11530	COG1033	growth of symbiont in host cell
FO458_RS11530	COG2409	Drug exporters of the RND superfamily
FO458_RS11550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FO458_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS11575	COG1278	Cold shock
FO458_RS11590	COG2311	Membrane
FO458_RS11595	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FO458_RS11605	COG1233	COG1233 Phytoene dehydrogenase and related
FO458_RS11625	COG2814	Major facilitator Superfamily
FO458_RS11640	COG1131	(ABC) transporter
FO458_RS11665	COG2264	protein methyltransferase activity
FO458_RS11670	COG0747	negative chemotaxis
FO458_RS11675	COG0601	transmembrane transport
FO458_RS11685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO458_RS11690	COG1124	(ABC) transporter
FO458_RS11695	COG3961	Belongs to the TPP enzyme family
FO458_RS11710	COG1131	(ABC) transporter
FO458_RS11720	COG2353	YceI-like domain
FO458_RS11725	COG1288	antiporter activity
FO458_RS11735	COG2814	Major facilitator Superfamily
FO458_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS11765	COG2190	(PTS) system
FO458_RS11765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS11765	COG1263	PTS System
FO458_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS11795	COG1053	succinate dehydrogenase
FO458_RS11795	COG3976	FMN-binding domain protein
FO458_RS11795	COG0431	NADPH-dependent FMN reductase
FO458_RS11820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO458_RS11825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO458_RS11830	COG0022	dehydrogenase e1 component
FO458_RS11840	COG1695	Transcriptional regulator
FO458_RS11860	COG3711	transcriptional antiterminator
FO458_RS11860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS11865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS11865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO458_RS11865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO458_RS11870	COG1482	cell wall glycoprotein biosynthetic process
FO458_RS11885	COG1846	Transcriptional regulator
FO458_RS11890	COG2814	Major facilitator Superfamily
FO458_RS11915	COG0706	membrane insertase activity
FO458_RS11925	COG0531	amino acid
FO458_RS11980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO458_RS12000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FO458_RS12010	COG0363	glucosamine-6-phosphate deaminase activity
FO458_RS12015	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FO458_RS12030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO458_RS12035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FO458_RS12045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO458_RS12080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FO458_RS12100	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FO458_RS12105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS12105	COG3711	transcriptional antiterminator
FO458_RS12110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO458_RS12120	COG3037	sugar-specific permease SgaT UlaA
FO458_RS12125	COG1054	Belongs to the UPF0176 family
FO458_RS12130	COG3386	PFAM SMP-30 Gluconolaconase
FO458_RS12145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO458_RS12155	COG1122	ATPase activity
FO458_RS12165	COG1476	TRANSCRIPTIONal
FO458_RS12200	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO458_RS12200	COG3942	CHAP domain
FO458_RS12225	COG2235	arginine
FO458_RS12235	COG2843	Capsule synthesis protein
FO458_RS12240	COG4195	phage-related replication protein
FO458_RS12285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO458_RS12310	COG0297	glycogen (starch) synthase activity
FO458_RS12320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FO458_RS12325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FO458_RS12330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO458_RS12335	COG1785	Belongs to the alkaline phosphatase family
FO458_RS12345	COG0745	RESPONSE REGULATOR receiver
FO458_RS12350	COG2205	protein histidine kinase activity
FO458_RS12355	COG1136	(ABC) transporter
FO458_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
FO458_RS12400	COG0175	sulfate reduction
FO458_RS12405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FO458_RS12410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO458_RS12425	COG0730	response to heat
FO458_RS12430	COG2046	Belongs to the sulfate adenylyltransferase family
FO458_RS12435	COG0529	Catalyzes the synthesis of activated sulfate
FO458_RS12450	COG1328	CTP reductase activity
FO458_RS12455	COG0602	queuosine metabolic process
FO458_RS12460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FO458_RS12465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO458_RS12470	COG1510	regulation of RNA biosynthetic process
FO458_RS12475	COG1012	belongs to the aldehyde dehydrogenase family
FO458_RS12480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FO458_RS12485	COG1473	amidohydrolase
FO458_RS12500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO458_RS12505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO458_RS12505	COG0574	Belongs to the PEP-utilizing enzyme family
FO458_RS12510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO458_RS12520	COG2188	Transcriptional regulator
FO458_RS12525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO458_RS12525	COG2190	(PTS) system
FO458_RS12525	COG1263	PTS System
FO458_RS12530	COG2723	6-phospho-beta-galactosidase activity
FO458_RS12540	COG0583	DNA-binding transcription factor activity
FO458_RS12555	COG3588	fructose-bisphosphate aldolase
FO458_RS12570	COG1464	Belongs to the NlpA lipoprotein family
FO458_RS12580	COG0463	Glycosyl transferase, family 2
FO458_RS12590	COG1215	transferase activity, transferring glycosyl groups
FO458_RS12590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO458_RS12600	COG0531	amino acid
FO458_RS12605	COG0583	DNA-binding transcription factor activity
FO458_RS12610	COG0028	Belongs to the TPP enzyme family
FO458_RS12615	COG3527	Alpha-acetolactate decarboxylase
FO458_RS12620	COG1620	l-lactate permease