locus-tag	class	description
FO454_RS00025	COG1757	Na H antiporter
FO454_RS00040	COG3942	CHAP domain
FO454_RS00045	COG2076	Multidrug Resistance protein
FO454_RS00050	COG2076	Multidrug Resistance protein
FO454_RS00055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO454_RS00080	COG1316	TRANSCRIPTIONal
FO454_RS00090	COG1349	DNA-binding transcription factor activity
FO454_RS00100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FO454_RS00105	COG1263	PTS System
FO454_RS00105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS00110	COG1737	Transcriptional regulator
FO454_RS00115	COG1113	amino acid transport
FO454_RS00135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FO454_RS00145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS00145	COG1263	PTS System
FO454_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS00175	COG1473	amidohydrolase
FO454_RS00185	COG1266	CAAX protease self-immunity
FO454_RS00190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FO454_RS00195	COG2258	MOSC domain
FO454_RS00200	COG2017	converts alpha-aldose to the beta-anomer
FO454_RS00210	COG2094	Belongs to the DNA glycosylase MPG family
FO454_RS00215	COG1304	FMN binding
FO454_RS00220	COG0598	Magnesium transport protein CorA
FO454_RS00245	COG2814	Major facilitator Superfamily
FO454_RS00250	COG1566	PFAM secretion protein HlyD family protein
FO454_RS00260	COG2814	Major facilitator Superfamily
FO454_RS00310	COG0579	oxidoreductase
FO454_RS00315	COG0297	glycogen (starch) synthase activity
FO454_RS00320	COG1620	l-lactate permease
FO454_RS00325	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS00335	COG0456	acetyltransferase
FO454_RS00340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FO454_RS00345	COG0805	protein transport
FO454_RS00350	COG0672	)-iron permease
FO454_RS00355	COG2837	iron assimilation
FO454_RS00360	COG2822	iron ion transport
FO454_RS00365	COG0604	alcohol dehydrogenase
FO454_RS00380	COG0492	ferredoxin-NADP+ reductase activity
FO454_RS00385	COG2314	TM2 domain
FO454_RS00405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FO454_RS00455	COG0583	DNA-binding transcription factor activity
FO454_RS00460	COG2814	Major facilitator Superfamily
FO454_RS00490	COG0488	(ABC) transporter
FO454_RS00505	COG2962	Rard protein
FO454_RS00510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FO454_RS00515	COG4716	Myosin-crossreactive antigen
FO454_RS00525	COG4413	Urea transporter
FO454_RS00530	COG0831	urea catabolic process
FO454_RS00540	COG0804	urea catabolic process
FO454_RS00545	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FO454_RS00560	COG0829	nickel cation binding
FO454_RS00570	COG0601	transmembrane transport
FO454_RS00580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO454_RS00585	COG1124	(ABC) transporter
FO454_RS00595	COG0534	Mate efflux family protein
FO454_RS00620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS00620	COG1263	PTS System
FO454_RS00660	COG1846	Transcriptional regulator
FO454_RS00665	COG2223	nitrite transmembrane transporter activity
FO454_RS00675	COG4585	Histidine kinase
FO454_RS00685	COG2181	nitrate reductase activity
FO454_RS00695	COG1140	nitrate reductase beta subunit
FO454_RS00700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FO454_RS00710	COG2146	nitrite reductase [NAD(P)H] activity
FO454_RS00715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO454_RS00725	COG2116	formate transmembrane transporter activity
FO454_RS00735	COG1131	(ABC) transporter
FO454_RS00775	COG1126	abc transporter atp-binding protein
FO454_RS00780	COG0765	amino acid transport
FO454_RS00785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO454_RS00790	COG2814	Major facilitator Superfamily
FO454_RS00800	COG0588	phosphoglycerate mutase activity
FO454_RS00805	COG0741	lytic transglycosylase activity
FO454_RS00810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FO454_RS00820	COG1929	Belongs to the glycerate kinase type-1 family
FO454_RS00830	COG2814	Major facilitator Superfamily
FO454_RS00850	COG1113	amino acid transport
FO454_RS00865	COG0531	amino acid
FO454_RS00875	COG0706	membrane insertase activity
FO454_RS00890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FO454_RS00900	COG3275	phosphorelay sensor kinase activity
FO454_RS00905	COG3279	Response regulator of the LytR AlgR family
FO454_RS00910	COG1380	Effector of murein hydrolase LrgA
FO454_RS00915	COG1346	cytolysis
FO454_RS00955	COG1174	glycine betaine transport
FO454_RS00975	COG1063	alcohol dehydrogenase
FO454_RS00980	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FO454_RS00985	COG2272	Belongs to the type-B carboxylesterase lipase family
FO454_RS00990	COG2814	Major facilitator Superfamily
FO454_RS01000	COG0745	RESPONSE REGULATOR receiver
FO454_RS01005	COG2205	protein histidine kinase activity
FO454_RS01010	COG0390	transport system, permease component
FO454_RS01015	COG4619	ABC transporter
FO454_RS01030	COG0069	glutamate synthase activity
FO454_RS01035	COG0737	Belongs to the 5'-nucleotidase family
FO454_RS01050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FO454_RS01055	COG3639	organic phosphonate transmembrane transporter activity
FO454_RS01085	COG1363	Peptidase, m42
FO454_RS01090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FO454_RS01095	COG0248	Ppx GppA phosphatase
FO454_RS01100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FO454_RS01105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO454_RS01110	COG4221	oxidoreductase activity
FO454_RS01125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO454_RS01130	COG0438	transferase activity, transferring glycosyl groups
FO454_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FO454_RS01150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FO454_RS01155	COG2610	gluconate transmembrane transporter activity
FO454_RS01160	COG1070	Carbohydrate kinase
FO454_RS01165	COG1802	Transcriptional regulator
FO454_RS01180	COG2357	RelA SpoT domain protein
FO454_RS01185	COG4876	unkown
FO454_RS01200	COG2271	Major facilitator Superfamily
FO454_RS01220	COG2022	thiamine diphosphate biosynthetic process
FO454_RS01230	COG0586	Pfam SNARE associated Golgi protein
FO454_RS01235	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FO454_RS01245	COG3949	Membrane
FO454_RS01250	COG0400	carboxylic ester hydrolase activity
FO454_RS01255	COG0346	lactoylglutathione lyase activity
FO454_RS01260	COG0346	lactoylglutathione lyase activity
FO454_RS01265	COG1846	Transcriptional regulator
FO454_RS01290	COG2388	GCN5-related N-acetyl-transferase
FO454_RS01295	COG2514	catechol 2,3-dioxygenase activity
FO454_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
FO454_RS01310	COG0778	Nitroreductase
FO454_RS01315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO454_RS01325	COG0561	phosphatase activity
FO454_RS01340	COG3764	Sortase (surface protein transpeptidase)
FO454_RS01350	COG1760	l-serine dehydratase
FO454_RS01355	COG1760	l-serine dehydratase
FO454_RS01365	COG1070	Carbohydrate kinase
FO454_RS01385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO454_RS01395	COG0657	acetylesterase activity
FO454_RS01400	COG0039	L-malate dehydrogenase activity
FO454_RS01405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO454_RS01420	COG0028	Belongs to the TPP enzyme family
FO454_RS01425	COG1346	cytolysis
FO454_RS01430	COG1380	Effector of murein hydrolase LrgA
FO454_RS01435	COG0583	DNA-binding transcription factor activity
FO454_RS01445	COG1388	LysM domain
FO454_RS01445	COG3942	CHAP domain
FO454_RS01460	COG3425	synthase
FO454_RS01470	COG1131	(ABC) transporter
FO454_RS01495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FO454_RS01500	COG0598	Magnesium transport protein CorA
FO454_RS01510	COG2409	Drug exporters of the RND superfamily
FO454_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
FO454_RS01525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO454_RS01530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS01535	COG0110	maltose O-acetyltransferase activity
FO454_RS01545	COG2217	Heavy metal translocating P-type atpase
FO454_RS01550	COG2608	mercury ion transmembrane transporter activity
FO454_RS01560	COG0436	Aminotransferase
FO454_RS01580	COG3189	MarR family transcriptional regulator
FO454_RS01590	COG1113	amino acid transport
FO454_RS01600	COG2814	Major facilitator Superfamily
FO454_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS01650	COG0596	Alpha beta hydrolase
FO454_RS01655	COG3001	Fructosamine kinase
FO454_RS01660	COG0167	dihydroorotate dehydrogenase activity
FO454_RS01680	COG1620	l-lactate permease
FO454_RS01685	COG3527	Alpha-acetolactate decarboxylase
FO454_RS01690	COG0028	Belongs to the TPP enzyme family
FO454_RS01695	COG0583	DNA-binding transcription factor activity
FO454_RS01710	COG1215	transferase activity, transferring glycosyl groups
FO454_RS01710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS01720	COG0463	Glycosyl transferase, family 2
FO454_RS01730	COG1464	Belongs to the NlpA lipoprotein family
FO454_RS01745	COG3588	fructose-bisphosphate aldolase
FO454_RS01760	COG0583	DNA-binding transcription factor activity
FO454_RS01770	COG2723	6-phospho-beta-galactosidase activity
FO454_RS01775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS01775	COG2190	(PTS) system
FO454_RS01775	COG1263	PTS System
FO454_RS01780	COG2188	Transcriptional regulator
FO454_RS01790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO454_RS01795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO454_RS01795	COG0574	Belongs to the PEP-utilizing enzyme family
FO454_RS01800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO454_RS01815	COG1473	amidohydrolase
FO454_RS01820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FO454_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
FO454_RS01830	COG1510	regulation of RNA biosynthetic process
FO454_RS01835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO454_RS01840	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FO454_RS01845	COG0602	queuosine metabolic process
FO454_RS01850	COG1328	CTP reductase activity
FO454_RS01865	COG0529	Catalyzes the synthesis of activated sulfate
FO454_RS01870	COG2046	Belongs to the sulfate adenylyltransferase family
FO454_RS01875	COG0730	response to heat
FO454_RS01890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO454_RS01895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FO454_RS01900	COG0175	sulfate reduction
FO454_RS01910	COG4932	domain protein
FO454_RS01910	COG3266	domain, Protein
FO454_RS01910	COG4932	domain protein
FO454_RS01910	COG3266	domain, Protein
FO454_RS01910	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FO454_RS01910	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FO454_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS01950	COG1136	(ABC) transporter
FO454_RS01955	COG2205	protein histidine kinase activity
FO454_RS01970	COG1785	Belongs to the alkaline phosphatase family
FO454_RS01975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO454_RS01980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FO454_RS01985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FO454_RS01995	COG0297	glycogen (starch) synthase activity
FO454_RS02020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO454_RS02060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FO454_RS02065	COG4195	phage-related replication protein
FO454_RS02070	COG2843	Capsule synthesis protein
FO454_RS02080	COG2235	arginine
FO454_RS02085	COG2226	methyltransferase
FO454_RS02095	COG0640	Transcriptional regulator
FO454_RS02140	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO454_RS02140	COG3942	CHAP domain
FO454_RS02175	COG1476	TRANSCRIPTIONal
FO454_RS02185	COG1122	ATPase activity
FO454_RS02195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO454_RS02210	COG3386	PFAM SMP-30 Gluconolaconase
FO454_RS02215	COG1054	Belongs to the UPF0176 family
FO454_RS02220	COG3037	sugar-specific permease SgaT UlaA
FO454_RS02230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS02235	COG3711	transcriptional antiterminator
FO454_RS02235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS02240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FO454_RS02260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FO454_RS02265	COG1266	CAAX protease self-immunity
FO454_RS02295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO454_RS02305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FO454_RS02310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO454_RS02325	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FO454_RS02330	COG0363	glucosamine-6-phosphate deaminase activity
FO454_RS02340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FO454_RS02360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO454_RS02415	COG0531	amino acid
FO454_RS02425	COG0706	membrane insertase activity
FO454_RS02450	COG1482	cell wall glycoprotein biosynthetic process
FO454_RS02455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO454_RS02455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO454_RS02455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS02460	COG3711	transcriptional antiterminator
FO454_RS02460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS02485	COG1695	Transcriptional regulator
FO454_RS02495	COG0022	dehydrogenase e1 component
FO454_RS02500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO454_RS02505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO454_RS02515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FO454_RS02530	COG3976	FMN-binding domain protein
FO454_RS02530	COG0431	NADPH-dependent FMN reductase
FO454_RS02530	COG1053	succinate dehydrogenase
FO454_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS02560	COG1263	PTS System
FO454_RS02560	COG2190	(PTS) system
FO454_RS02560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS02590	COG2814	Major facilitator Superfamily
FO454_RS02600	COG1288	antiporter activity
FO454_RS02605	COG2353	YceI-like domain
FO454_RS02615	COG1131	(ABC) transporter
FO454_RS02630	COG3961	Belongs to the TPP enzyme family
FO454_RS02635	COG1124	(ABC) transporter
FO454_RS02640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO454_RS02650	COG0601	transmembrane transport
FO454_RS02655	COG0747	negative chemotaxis
FO454_RS02660	COG2264	protein methyltransferase activity
FO454_RS02685	COG1131	(ABC) transporter
FO454_RS02700	COG2814	Major facilitator Superfamily
FO454_RS02720	COG1233	COG1233 Phytoene dehydrogenase and related
FO454_RS02730	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FO454_RS02735	COG2311	Membrane
FO454_RS02750	COG1278	Cold shock
FO454_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS02770	COG1131	(ABC) transporter
FO454_RS02785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FO454_RS02805	COG1033	growth of symbiont in host cell
FO454_RS02805	COG2409	Drug exporters of the RND superfamily
FO454_RS02845	COG0657	acetylesterase activity
FO454_RS02850	COG0505	Belongs to the CarA family
FO454_RS02855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO454_RS02855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO454_RS02860	COG0531	amino acid
FO454_RS02865	COG0693	protein deglycase activity
FO454_RS02880	COG1124	(ABC) transporter
FO454_RS02885	COG0444	Belongs to the ABC transporter superfamily
FO454_RS02895	COG0601	transmembrane transport
FO454_RS02910	COG2814	Major facilitator Superfamily
FO454_RS02915	COG0561	phosphatase activity
FO454_RS02920	COG0464	growth
FO454_RS02930	COG1114	Component of the transport system for branched-chain amino acids
FO454_RS02940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FO454_RS02955	COG2610	gluconate transmembrane transporter activity
FO454_RS02960	COG4948	Mandelate Racemase Muconate Lactonizing
FO454_RS02965	COG0800	Aldolase
FO454_RS02975	COG1414	Transcriptional regulator
FO454_RS02980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FO454_RS02985	COG1177	transmembrane transport
FO454_RS02990	COG1840	ABC-type Fe3 transport system, periplasmic component
FO454_RS02995	COG3842	ATPase activity
FO454_RS03000	COG0583	DNA-binding transcription factor activity
FO454_RS03035	COG5002	protein histidine kinase activity
FO454_RS03045	COG1349	DNA-binding transcription factor activity
FO454_RS03050	COG0534	Mate efflux family protein
FO454_RS03060	COG0395	ABC-type sugar transport system, permease component
FO454_RS03070	COG4209	transmembrane transport
FO454_RS03075	COG3842	ATPase activity
FO454_RS03090	COG1846	Transcriptional regulator
FO454_RS03100	COG2808	Putative FMN-binding domain
FO454_RS03105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO454_RS03110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS03115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS03120	COG3942	CHAP domain
FO454_RS03120	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO454_RS03130	COG4509	Sortase family
FO454_RS03165	COG1129	ABC transporter
FO454_RS03190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FO454_RS03195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FO454_RS03205	COG2205	protein histidine kinase activity
FO454_RS03210	COG0745	RESPONSE REGULATOR receiver
FO454_RS03225	COG3716	PTS system mannose fructose sorbose family IID component
FO454_RS03230	COG3715	PTS system
FO454_RS03235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS03240	COG3684	Belongs to the aldolase LacD family
FO454_RS03245	COG2222	sugar isomerase
FO454_RS03250	COG2188	Transcriptional regulator
FO454_RS03330	COG1332	CRISPR-associated RAMP protein, Csm5 family
FO454_RS03335	COG1567	CRISPR-associated RAMP protein, Csm4 family
FO454_RS03340	COG1337	RAMP superfamily
FO454_RS03345	COG1421	Csm2 Type III-A
FO454_RS03350	COG1353	crispr-associated protein
FO454_RS03355	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FO454_RS03360	COG1518	maintenance of DNA repeat elements
FO454_RS03365	COG1131	(ABC) transporter
FO454_RS03380	COG0745	RESPONSE REGULATOR receiver
FO454_RS03420	COG1129	ABC transporter
FO454_RS03445	COG1073	alpha beta
FO454_RS03475	COG1522	sequence-specific DNA binding
FO454_RS03490	COG0640	Transcriptional regulator
FO454_RS03495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO454_RS03585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FO454_RS03590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FO454_RS03625	COG4863	YycH protein
FO454_RS03630	COG5002	protein histidine kinase activity
FO454_RS03635	COG0745	RESPONSE REGULATOR receiver
FO454_RS03650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FO454_RS03655	COG0305	Participates in initiation and elongation during chromosome replication
FO454_RS03660	COG0359	binds to the 23S rRNA
FO454_RS03665	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FO454_RS03675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FO454_RS03685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FO454_RS03695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FO454_RS03700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO454_RS03705	COG0187	DNA topoisomerase II activity
FO454_RS03710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FO454_RS03715	COG2501	S4 domain
FO454_RS03720	COG0592	DNA-directed DNA polymerase activity
FO454_RS03725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FO454_RS03735	COG0594	ribonuclease P activity
FO454_RS03740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FO454_RS03745	COG0445	tRNA wobble uridine modification
FO454_RS03755	COG1475	DNA binding
FO454_RS03775	COG1063	alcohol dehydrogenase
FO454_RS03790	COG1028	Short-chain dehydrogenase reductase Sdr
FO454_RS03800	COG1396	sequence-specific DNA binding
FO454_RS03810	COG0577	efflux transmembrane transporter activity
FO454_RS03815	COG1136	(ABC) transporter
FO454_RS03830	COG2271	Major facilitator Superfamily
FO454_RS03835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FO454_RS03840	COG3878	Protein conserved in bacteria
FO454_RS03865	COG0745	RESPONSE REGULATOR receiver
FO454_RS03880	COG2205	protein histidine kinase activity
FO454_RS03900	COG1136	(ABC) transporter
FO454_RS03905	COG0577	efflux transmembrane transporter activity
FO454_RS03935	COG0646	methionine synthase
FO454_RS03935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FO454_RS03940	COG0626	cystathionine gamma-synthase activity
FO454_RS03945	COG0626	cystathionine gamma-synthase activity
FO454_RS03950	COG1475	DNA binding
FO454_RS03955	COG0668	transmembrane transport
FO454_RS03960	COG4481	Protein conserved in bacteria
FO454_RS03965	COG0012	GTP binding
FO454_RS03980	COG0360	Binds together with S18 to 16S ribosomal RNA
FO454_RS03990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FO454_RS04030	COG0588	phosphoglycerate mutase activity
FO454_RS04045	COG3634	alkyl hydroperoxide reductase activity
FO454_RS04050	COG0450	alkyl hydroperoxide reductase
FO454_RS04060	COG0778	Nitroreductase
FO454_RS04070	COG1823	symporter activity
FO454_RS04090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO454_RS04095	COG2233	PERMEase
FO454_RS04100	COG0516	GMP reductase activity
FO454_RS04100	COG0517	IMP dehydrogenase activity
FO454_RS04105	COG0519	Catalyzes the synthesis of GMP from XMP
FO454_RS04105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FO454_RS04125	COG0523	cobalamin synthesis protein
FO454_RS04135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO454_RS04140	COG3002	Belongs to the UPF0753 family
FO454_RS04145	COG5609	conserved protein (DUF2294)
FO454_RS04165	COG0733	neurotransmitter:sodium symporter activity
FO454_RS04175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO454_RS04180	COG0626	cystathionine gamma-synthase activity
FO454_RS04185	COG2375	cellular response to nickel ion
FO454_RS04185	COG1132	(ABC) transporter
FO454_RS04190	COG1132	(ABC) transporter
FO454_RS04195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO454_RS04200	COG2011	ABC-type metal ion transport system permease component
FO454_RS04205	COG1464	Belongs to the NlpA lipoprotein family
FO454_RS04235	COG0583	DNA-binding transcription factor activity
FO454_RS04240	COG0070	glutamate synthase
FO454_RS04240	COG0069	glutamate synthase activity
FO454_RS04240	COG0067	glutamate synthase
FO454_RS04245	COG0493	'glutamate synthase
FO454_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS04255	COG1263	PTS System
FO454_RS04260	COG0366	Alpha amylase catalytic
FO454_RS04265	COG2188	Transcriptional regulator
FO454_RS04280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FO454_RS04290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FO454_RS04330	COG1982	Orn Lys Arg decarboxylase major
FO454_RS04335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FO454_RS04340	COG3870	Protein conserved in bacteria
FO454_RS04345	COG0470	DNA polymerase III
FO454_RS04350	COG1774	PSP1 C-terminal conserved region
FO454_RS04360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FO454_RS04370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FO454_RS04375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO454_RS04375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO454_RS04380	COG0084	hydrolase, TatD family'
FO454_RS04385	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO454_RS04390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FO454_RS04395	COG4466	Protein conserved in bacteria
FO454_RS04400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FO454_RS04405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO454_RS04410	COG0251	oxidation-reduction process
FO454_RS04420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FO454_RS04425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FO454_RS04435	COG0193	aminoacyl-tRNA hydrolase activity
FO454_RS04440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FO454_RS04445	COG2244	polysaccharide biosynthetic process
FO454_RS04450	COG3956	TIGRFAM MazG family protein
FO454_RS04455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FO454_RS04465	COG1098	S1 RNA binding domain
FO454_RS04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FO454_RS04490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO454_RS04500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FO454_RS04505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FO454_RS04515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FO454_RS04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FO454_RS04605	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FO454_RS04610	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FO454_RS04615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO454_RS04620	COG4463	regulation of RNA biosynthetic process
FO454_RS04625	COG3880	PFAM UvrB UvrC protein
FO454_RS04630	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FO454_RS04635	COG0542	response to heat
FO454_RS04640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FO454_RS04645	COG4956	integral membrane protein (PIN domain superfamily)
FO454_RS04650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FO454_RS04655	COG1045	serine acetyltransferase
FO454_RS04660	COG0215	cysteine-tRNA ligase activity
FO454_RS04665	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FO454_RS04670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO454_RS04675	COG3688	RNA-binding protein containing a PIN domain
FO454_RS04685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO454_RS04690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO454_RS04695	COG0250	Participates in transcription elongation, termination and antitermination
FO454_RS04705	COG0081	regulation of translation
FO454_RS04715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FO454_RS04720	COG0222	ribosome binding
FO454_RS04725	COG2813	Specifically methylates the guanine in position
FO454_RS04730	COG0085	RNA polymerase activity
FO454_RS04735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FO454_RS04760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FO454_RS04765	COG1473	amidohydrolase
FO454_RS04800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FO454_RS04805	COG0531	amino acid
FO454_RS04825	COG1428	Deoxynucleoside kinase
FO454_RS04830	COG1428	Deoxynucleoside kinase
FO454_RS04840	COG0561	phosphatase activity
FO454_RS04865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS04875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FO454_RS04885	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FO454_RS04890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FO454_RS04925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FO454_RS04935	COG2363	Small membrane protein
FO454_RS04970	COG3253	May function as heme-dependent peroxidase
FO454_RS04980	COG0095	Lipoate-protein ligase
FO454_RS05000	COG4844	belongs to the
FO454_RS05005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO454_RS05010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO454_RS05085	COG0629	single-stranded DNA binding
FO454_RS05100	COG1484	DNA-dependent DNA replication
FO454_RS05135	COG0756	dUTP diphosphatase activity
FO454_RS05160	COG1783	phage Terminase large subunit
FO454_RS05270	COG2723	6-phospho-beta-galactosidase activity
FO454_RS05280	COG2130	NADP-dependent
FO454_RS05285	COG0604	alcohol dehydrogenase
FO454_RS05315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FO454_RS05320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS05325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS05330	COG3314	Sporulation integral membrane protein YlbJ
FO454_RS05340	COG1988	membrane-bound metal-dependent
FO454_RS05345	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FO454_RS05350	COG1272	protein, Hemolysin III
FO454_RS05365	COG2814	Major facilitator Superfamily
FO454_RS05370	COG0489	protein tyrosine kinase activity
FO454_RS05440	COG0561	phosphatase activity
FO454_RS05460	COG0640	Transcriptional regulator
FO454_RS05465	COG0702	epimerase
FO454_RS05470	COG1482	cell wall glycoprotein biosynthetic process
FO454_RS05490	COG0783	Belongs to the Dps family
FO454_RS05495	COG0813	purine-nucleoside phosphorylase activity
FO454_RS05500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FO454_RS05505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FO454_RS05510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FO454_RS05540	COG1854	S-ribosylhomocysteine lyase activity
FO454_RS05560	COG5146	pantothenate kinase activity
FO454_RS05570	COG3343	RNA polymerase activity
FO454_RS05575	COG0504	CTP synthase activity
FO454_RS05585	COG0191	fructose-bisphosphate aldolase activity
FO454_RS05590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO454_RS05600	COG1012	belongs to the aldehyde dehydrogenase family
FO454_RS05605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FO454_RS05610	COG0254	rRNA binding
FO454_RS05620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FO454_RS05625	COG2890	protein-(glutamine-N5) methyltransferase activity
FO454_RS05630	COG0009	L-threonylcarbamoyladenylate synthase
FO454_RS05635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO454_RS05640	COG4475	Protein of unknown function (DUF436)
FO454_RS05645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FO454_RS05660	COG0356	it plays a direct role in the translocation of protons across the membrane
FO454_RS05665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO454_RS05670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FO454_RS05675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO454_RS05685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FO454_RS05690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FO454_RS05700	COG4836	Membrane
FO454_RS05705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO454_RS05710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FO454_RS05720	COG0629	single-stranded DNA binding
FO454_RS05730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FO454_RS05740	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FO454_RS05745	COG0352	thiamine-phosphate diphosphorylase activity
FO454_RS05750	COG0706	membrane insertase activity
FO454_RS05755	COG1418	mRNA catabolic process
FO454_RS05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO454_RS05765	COG1937	Protein conserved in bacteria
FO454_RS05775	COG0772	Belongs to the SEDS family
FO454_RS05780	COG1181	Belongs to the D-alanine--D-alanine ligase family
FO454_RS05785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FO454_RS05790	COG0513	Belongs to the DEAD box helicase family
FO454_RS05800	COG3428	Bacterial PH domain
FO454_RS05810	COG0736	holo-[acyl-carrier-protein] synthase activity
FO454_RS05825	COG2337	Toxic component of a toxin-antitoxin (TA) module
FO454_RS05830	COG2208	phosphoserine phosphatase activity
FO454_RS05845	COG1191	sigma factor activity
FO454_RS05850	COG2183	response to ionizing radiation
FO454_RS05890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FO454_RS05895	COG0066	3-isopropylmalate dehydratase activity
FO454_RS05900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FO454_RS05910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO454_RS05925	COG0028	Belongs to the TPP enzyme family
FO454_RS05935	COG0802	atpase or kinase
FO454_RS05940	COG1214	PFAM Peptidase M22, glycoprotease
FO454_RS05945	COG0456	acetyltransferase
FO454_RS05950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FO454_RS05955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO454_RS05960	COG0488	(ABC) transporter
FO454_RS05965	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FO454_RS05970	COG2391	methyltransferase activity
FO454_RS05975	COG0425	Belongs to the sulfur carrier protein TusA family
FO454_RS05980	COG0004	ammonium transporteR
FO454_RS05985	COG1609	Transcriptional regulator
FO454_RS05990	COG1621	beta-fructofuranosidase activity
FO454_RS05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO454_RS06015	COG4512	PFAM Accessory gene regulator B
FO454_RS06020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FO454_RS06045	COG0459	protein refolding
FO454_RS06050	COG0582	viral genome integration into host DNA
FO454_RS06125	COG3728	DNA packaging
FO454_RS06125	COG5484	DNA packaging
FO454_RS06145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO454_RS06150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FO454_RS06165	COG1725	Transcriptional regulator
FO454_RS06170	COG0842	Transport permease protein
FO454_RS06170	COG1129	ABC transporter
FO454_RS06180	COG1131	(ABC) transporter
FO454_RS06220	COG2706	6-phosphogluconolactonase activity
FO454_RS06225	COG1012	belongs to the aldehyde dehydrogenase family
FO454_RS06230	COG1227	inorganic diphosphatase activity
FO454_RS06235	COG1335	isochorismatase
FO454_RS06250	COG0077	Prephenate dehydratase
FO454_RS06260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FO454_RS06265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FO454_RS06270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FO454_RS06280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FO454_RS06285	COG4496	protein, YerC YecD
FO454_RS06290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FO454_RS06300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FO454_RS06305	COG4851	CamS sex pheromone cAM373 precursor
FO454_RS06325	COG0154	amidase activity
FO454_RS06330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FO454_RS06335	COG1597	lipid kinase activity
FO454_RS06340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FO454_RS06365	COG1528	Iron-storage protein
FO454_RS06385	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO454_RS06390	COG4129	membrane
FO454_RS06395	COG0024	Methionine aminopeptidase
FO454_RS06420	COG1295	ribonuclease BN
FO454_RS06430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO454_RS06435	COG4840	Belongs to the UPF0435 family
FO454_RS06440	COG2309	aminopeptidase activity
FO454_RS06445	COG1607	acyl-coa hydrolase
FO454_RS06450	COG0535	radical SAM domain protein
FO454_RS06460	COG0693	protein deglycase activity
FO454_RS06465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO454_RS06470	COG2137	regulation of response to DNA damage stimulus
FO454_RS06480	COG1388	LysM domain
FO454_RS06480	COG1134	teichoic acid transport
FO454_RS06490	COG1988	membrane-bound metal-dependent
FO454_RS06495	COG1194	a g-specific adenine glycosylase
FO454_RS06500	COG3557	Belongs to the UPF0374 family
FO454_RS06510	COG4129	membrane
FO454_RS06515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO454_RS06520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FO454_RS06530	COG0735	belongs to the Fur family
FO454_RS06700	COG0765	amino acid transport
FO454_RS06705	COG1126	abc transporter atp-binding protein
FO454_RS06710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FO454_RS06720	COG0363	glucosamine-6-phosphate deaminase activity
FO454_RS06735	COG0114	fumarate hydratase activity
FO454_RS06740	COG0564	pseudouridine synthase activity
FO454_RS06745	COG2203	Gaf domain
FO454_RS06745	COG4585	Histidine kinase
FO454_RS06750	COG2197	response regulator
FO454_RS06765	COG3679	Belongs to the UPF0342 family
FO454_RS06770	COG0420	3'-5' exonuclease activity
FO454_RS06795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FO454_RS06810	COG0537	adenosine 5'-monophosphoramidase activity
FO454_RS06815	COG1131	(ABC) transporter
FO454_RS06820	COG4473	ABC transporter
FO454_RS06825	COG2329	Antibiotic biosynthesis monooxygenase
FO454_RS06830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FO454_RS06840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FO454_RS06845	COG3545	Serine hydrolase
FO454_RS06895	COG0318	PFAM AMP-dependent synthetase and ligase
FO454_RS06905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FO454_RS06915	COG1506	peptidase
FO454_RS06920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FO454_RS06925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FO454_RS06935	COG0656	L-ascorbic acid biosynthetic process
FO454_RS06940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FO454_RS06955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FO454_RS06980	COG5632	N-Acetylmuramoyl-L-alanine amidase
FO454_RS06980	COG3266	domain, Protein
FO454_RS06980	COG4193	domain, Protein
FO454_RS06990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO454_RS06990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO454_RS07000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO454_RS07000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO454_RS07005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FO454_RS07010	COG0506	proline dehydrogenase activity
FO454_RS07015	COG2267	carboxylic ester hydrolase activity
FO454_RS07025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FO454_RS07030	COG1242	4 iron, 4 sulfur cluster binding
FO454_RS07035	COG2814	Major facilitator Superfamily
FO454_RS07040	COG0495	leucyl-tRNA aminoacylation
FO454_RS07050	COG2081	HI0933 family
FO454_RS07055	COG2244	polysaccharide biosynthetic process
FO454_RS07060	COG1187	pseudouridine synthase activity
FO454_RS07070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO454_RS07080	COG0510	thiamine kinase activity
FO454_RS07085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FO454_RS07095	COG5584	Small secreted protein
FO454_RS07100	COG1363	Peptidase, m42
FO454_RS07105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO454_RS07110	COG4848	Belongs to the UPF0354 family
FO454_RS07115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO454_RS07120	COG1674	ftsk spoiiie
FO454_RS07125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FO454_RS07130	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FO454_RS07140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FO454_RS07140	COG1605	Chorismate mutase
FO454_RS07145	COG1609	Transcriptional regulator
FO454_RS07160	COG0123	including yeast histone deacetylase and acetoin utilization protein
FO454_RS07165	COG0454	-acetyltransferase
FO454_RS07170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO454_RS07175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FO454_RS07185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FO454_RS07190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO454_RS07195	COG0204	Acyl-transferase
FO454_RS07200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO454_RS07200	COG1263	PTS System
FO454_RS07210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FO454_RS07215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FO454_RS07220	COG1764	response to oxidative stress
FO454_RS07225	COG0584	glycerophosphoryl diester phosphodiesterase
FO454_RS07230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FO454_RS07240	COG1956	GAF domain-containing protein
FO454_RS07245	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FO454_RS07250	COG1104	cysteine desulfurase activity
FO454_RS07255	COG0301	tRNA thio-modification
FO454_RS07260	COG0730	response to heat
FO454_RS07265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FO454_RS07270	COG0827	DNA restriction-modification system
FO454_RS07275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FO454_RS07280	COG0589	response to stress
FO454_RS07285	COG0686	Belongs to the AlaDH PNT family
FO454_RS07290	COG0006	proline dipeptidase activity
FO454_RS07295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FO454_RS07305	COG4109	DRTGG domain
FO454_RS07310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FO454_RS07315	COG0587	DNA-directed DNA polymerase activity
FO454_RS07320	COG0281	malic enzyme
FO454_RS07325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FO454_RS07330	COG0825	malonyl-CoA metabolic process
FO454_RS07335	COG0205	6-phosphofructokinase activity
FO454_RS07340	COG0469	pyruvate kinase activity
FO454_RS07345	COG1113	amino acid transport
FO454_RS07350	COG0372	Belongs to the citrate synthase family
FO454_RS07355	COG0538	isocitrate dehydrogenase activity
FO454_RS07360	COG0745	RESPONSE REGULATOR receiver
FO454_RS07365	COG5002	protein histidine kinase activity
FO454_RS07370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO454_RS07370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO454_RS07375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FO454_RS07380	COG0237	dephospho-CoA kinase activity
FO454_RS07385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FO454_RS07390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FO454_RS07395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FO454_RS07400	COG3611	Membrane attachment protein
FO454_RS07405	COG1484	DNA-dependent DNA replication
FO454_RS07415	COG0833	amino acid
FO454_RS07420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FO454_RS07425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FO454_RS07430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FO454_RS07435	COG4112	unkown
FO454_RS07445	COG0544	peptidyl-prolyl cis-trans isomerase activity
FO454_RS07450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FO454_RS07465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FO454_RS07470	COG0181	hydroxymethylbilane synthase activity
FO454_RS07485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO454_RS07495	COG2818	Glycosylase
FO454_RS07500	COG0525	valine-tRNA ligase activity
FO454_RS07505	COG0285	dihydrofolate synthase activity
FO454_RS07515	COG2003	Belongs to the UPF0758 family
FO454_RS07530	COG1792	Involved in formation and maintenance of cell shape
FO454_RS07540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FO454_RS07545	COG2868	ribosomal protein
FO454_RS07555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FO454_RS07560	COG4492	Belongs to the UPF0735 family
FO454_RS07565	COG0632	four-way junction helicase activity
FO454_RS07570	COG2255	four-way junction helicase activity
FO454_RS07575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FO454_RS07580	COG0343	queuine tRNA-ribosyltransferase activity
FO454_RS07585	COG1862	Preprotein translocase
FO454_RS07590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO454_RS07590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO454_RS07595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FO454_RS07595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FO454_RS07605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FO454_RS07610	COG1490	D-aminoacyl-tRNA deacylase activity
FO454_RS07615	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO454_RS07620	COG0124	histidyl-tRNA synthetase
FO454_RS07625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FO454_RS07635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FO454_RS07640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FO454_RS07645	COG1959	2 iron, 2 sulfur cluster binding
FO454_RS07655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO454_RS07660	COG1104	cysteine desulfurase activity
FO454_RS07665	COG0482	sulfurtransferase activity
FO454_RS07675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FO454_RS07680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FO454_RS07685	COG4472	Bacterial protein of unknown function (DUF965)
FO454_RS07690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FO454_RS07700	COG4122	O-methyltransferase activity
FO454_RS07705	COG0826	peptidase U32
FO454_RS07710	COG0826	peptidase U32
FO454_RS07715	COG0572	uridine kinase
FO454_RS07720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FO454_RS07725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO454_RS07730	COG1984	allophanate hydrolase subunit 2
FO454_RS07735	COG0511	ligase activity, forming carbon-carbon bonds
FO454_RS07740	COG0439	Biotin carboxylase
FO454_RS07750	COG1914	H( )-stimulated, divalent metal cation uptake system
FO454_RS07755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FO454_RS07760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FO454_RS07765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FO454_RS07775	COG1534	Rna-binding protein
FO454_RS07780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FO454_RS07785	COG1713	HD superfamily hydrolase involved in NAD metabolism
FO454_RS07790	COG0799	negative regulation of ribosome biogenesis
FO454_RS07795	COG2226	methyltransferase
FO454_RS07805	COG2131	deaminase
FO454_RS07815	COG1466	dna polymerase III delta subunit
FO454_RS07820	COG0268	Binds directly to 16S ribosomal RNA
FO454_RS07825	COG0481	GTPase activity
FO454_RS07830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FO454_RS07840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FO454_RS07845	COG0443	Heat shock 70 kDa protein
FO454_RS07850	COG0484	heat shock protein binding
FO454_RS07855	COG2264	protein methyltransferase activity
FO454_RS07860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FO454_RS07865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO454_RS07875	COG1030	water channel activity
FO454_RS07880	COG4864	UPF0365 protein
FO454_RS07890	COG1702	phosphate starvation-inducible protein PhoH
FO454_RS07895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FO454_RS07900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FO454_RS07905	COG0295	cytidine deaminase activity
FO454_RS07910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FO454_RS07915	COG1381	Involved in DNA repair and RecF pathway recombination
FO454_RS07920	COG0423	glycine-tRNA ligase activity
FO454_RS07925	COG0517	IMP dehydrogenase activity
FO454_RS07930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO454_RS07945	COG2384	SAM-dependent methyltransferase
FO454_RS07955	COG0513	Belongs to the DEAD box helicase family
FO454_RS07960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FO454_RS07965	COG1121	(ABC) transporter
FO454_RS07970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO454_RS07980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FO454_RS07985	COG0768	penicillin binding
FO454_RS07990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO454_RS07995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FO454_RS08000	COG0457	Tetratricopeptide repeat
FO454_RS08000	COG0705	Rhomboid family
FO454_RS08005	COG4483	Protein conserved in bacteria
FO454_RS08010	COG1940	carbohydrate kinase activity
FO454_RS08015	COG0011	TIGRFAM Protein of
FO454_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO454_RS08025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FO454_RS08030	COG1459	type II secretion system
FO454_RS08035	COG4537	Required for transformation and DNA binding
FO454_RS08060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FO454_RS08065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FO454_RS08070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO454_RS08075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO454_RS08080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FO454_RS08085	COG0095	Lipoate-protein ligase
FO454_RS08105	COG0006	proline dipeptidase activity
FO454_RS08110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FO454_RS08115	COG0511	ligase activity, forming carbon-carbon bonds
FO454_RS08120	COG0439	Biotin carboxylase
FO454_RS08125	COG1302	Protein conserved in bacteria
FO454_RS08130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO454_RS08150	COG1438	arginine binding
FO454_RS08155	COG0497	DNA recombination
FO454_RS08160	COG0280	phosphate acetyltransferase
FO454_RS08165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO454_RS08170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO454_RS08175	COG0022	dehydrogenase e1 component
FO454_RS08180	COG0508	dehydrogenase complex catalyzes the overall conversion of
FO454_RS08190	COG4129	membrane
FO454_RS08200	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO454_RS08210	COG1609	Transcriptional regulator
FO454_RS08215	COG0366	Alpha amylase catalytic
FO454_RS08225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FO454_RS08235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FO454_RS08240	COG0300	oxidoreductase activity
FO454_RS08245	COG0667	Aldo Keto reductase
FO454_RS08250	COG0494	nUDIX hydrolase
FO454_RS08255	COG0735	belongs to the Fur family
FO454_RS08260	COG4974	Belongs to the 'phage' integrase family
FO454_RS08270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FO454_RS08275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FO454_RS08280	COG1187	pseudouridine synthase activity
FO454_RS08285	COG0745	RESPONSE REGULATOR receiver
FO454_RS08300	COG1141	Ferredoxin
FO454_RS08310	COG0514	ATP-dependent DNA helicase (RecQ)
FO454_RS08315	COG1388	LysM domain
FO454_RS08325	COG0492	ferredoxin-NADP+ reductase activity
FO454_RS08345	COG0539	negative regulation of cytoplasmic translation
FO454_RS08355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FO454_RS08370	COG2226	methyltransferase
FO454_RS08375	COG0142	geranyltranstransferase activity
FO454_RS08385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FO454_RS08390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FO454_RS08415	COG2738	Putative neutral zinc metallopeptidase
FO454_RS08420	COG1694	Mazg nucleotide pyrophosphohydrolase
FO454_RS08425	COG0438	transferase activity, transferring glycosyl groups
FO454_RS08430	COG0617	tRNA 3'-terminal CCA addition
FO454_RS08435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FO454_RS08435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FO454_RS08440	COG1199	ATP-dependent helicase activity
FO454_RS08440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FO454_RS08445	COG0017	Asparaginyl-tRNA synthetase
FO454_RS08450	COG3935	DnaD domain protein
FO454_RS08455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FO454_RS08465	COG4499	WXG100 protein secretion system (Wss), protein YukC
FO454_RS08465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO454_RS08480	COG4474	Belongs to the UPF0398 family
FO454_RS08485	COG3599	regulation of cell shape
FO454_RS08495	COG0116	Belongs to the methyltransferase superfamily
FO454_RS08505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FO454_RS08510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO454_RS08515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO454_RS08520	COG0512	Glutamine amidotransferase of anthranilate synthase
FO454_RS08525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO454_RS08530	COG0134	indole-3-glycerol-phosphate synthase activity
FO454_RS08535	COG0135	phosphoribosylanthranilate isomerase activity
FO454_RS08550	COG2348	transferase activity, transferring amino-acyl groups
FO454_RS08555	COG2348	transferase activity, transferring amino-acyl groups
FO454_RS08560	COG0561	phosphatase activity
FO454_RS08565	COG4607	ABC-type enterochelin transport system periplasmic component
FO454_RS08575	COG1164	Oligoendopeptidase f
FO454_RS08585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FO454_RS08590	COG0581	inorganic phosphate transmembrane transporter activity
FO454_RS08595	COG0573	inorganic phosphate transmembrane transporter activity
FO454_RS08600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FO454_RS08605	COG2996	Protein conserved in bacteria
FO454_RS08610	COG0488	(ABC) transporter
FO454_RS08615	COG0527	aspartate kinase activity
FO454_RS08620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FO454_RS08625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO454_RS08630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FO454_RS08635	COG2171	N-acyltransferase activity
FO454_RS08640	COG1473	amidohydrolase
FO454_RS08665	COG1278	Cold shock
FO454_RS08675	COG1254	Belongs to the acylphosphatase family
FO454_RS08685	COG3853	Toxic anion resistance protein (TelA)
FO454_RS08690	COG1114	Component of the transport system for branched-chain amino acids
FO454_RS08695	COG4548	von Willebrand factor, type A
FO454_RS08700	COG0714	Associated with various cellular activities
FO454_RS08720	COG0567	Dehydrogenase, E1 component
FO454_RS08725	COG5002	protein histidine kinase activity
FO454_RS08730	COG0745	RESPONSE REGULATOR receiver
FO454_RS08735	COG0671	phosphoesterase, PA-phosphatase related
FO454_RS08740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO454_RS08750	COG0793	Belongs to the peptidase S41A family
FO454_RS08755	COG4479	Belongs to the UPF0346 family
FO454_RS08765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO454_RS08795	COG1413	lyase activity
FO454_RS08805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FO454_RS08810	COG0328	RNA-DNA hybrid ribonuclease activity
FO454_RS08815	COG1363	Peptidase, m42
FO454_RS08830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS08840	COG3623	hexulose-6-phosphate isomerase
FO454_RS08860	COG0287	Prephenate dehydrogenase
FO454_RS08865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FO454_RS08870	COG1942	4-Oxalocrotonate Tautomerase
FO454_RS08900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FO454_RS08900	COG0392	lysyltransferase activity
FO454_RS08905	COG0628	permease
FO454_RS08910	COG1115	amino acid carrier protein
FO454_RS08915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO454_RS08920	COG0187	DNA topoisomerase II activity
FO454_RS08925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FO454_RS08930	COG4841	protein insertion into membrane
FO454_RS08940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FO454_RS08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO454_RS08950	COG1970	mechanosensitive ion channel activity
FO454_RS08965	COG4846	Membrane protein involved in cytochrome C biogenesis
FO454_RS08970	COG3763	UPF0154 protein
FO454_RS08975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FO454_RS08980	COG4224	UPF0291 protein
FO454_RS08990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO454_RS09000	COG2340	Cysteine-rich secretory protein family
FO454_RS09010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FO454_RS09025	COG0833	amino acid
FO454_RS09040	COG0561	phosphatase activity
FO454_RS09045	COG0083	homoserine kinase activity
FO454_RS09050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FO454_RS09055	COG0460	homoserine dehydrogenase
FO454_RS09060	COG0527	aspartate kinase activity
FO454_RS09075	COG1525	nuclease
FO454_RS09090	COG2197	response regulator
FO454_RS09095	COG2203	Gaf domain
FO454_RS09095	COG4585	Histidine kinase
FO454_RS09105	COG1131	(ABC) transporter
FO454_RS09110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO454_RS09125	COG0789	Transcriptional regulator
FO454_RS09130	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FO454_RS09135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FO454_RS09145	COG1923	regulation of RNA biosynthetic process
FO454_RS09150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FO454_RS09160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FO454_RS09165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FO454_RS09170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FO454_RS09180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FO454_RS09185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO454_RS09200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO454_RS09215	COG4195	phage-related replication protein
FO454_RS09220	COG1013	pyruvate-flavodoxin oxidoreductase activity
FO454_RS09225	COG0674	pyruvate-flavodoxin oxidoreductase activity
FO454_RS09225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FO454_RS09230	COG1692	metallophosphoesterase
FO454_RS09240	COG1418	mRNA catabolic process
FO454_RS09245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FO454_RS09250	COG1058	Belongs to the CinA family
FO454_RS09250	COG1546	Belongs to the CinA family
FO454_RS09270	COG0300	oxidoreductase activity
FO454_RS09275	COG0612	Peptidase, M16
FO454_RS09280	COG0612	Peptidase, M16
FO454_RS09285	COG2188	Transcriptional regulator
FO454_RS09290	COG1674	ftsk spoiiie
FO454_RS09295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO454_RS09300	COG1185	polyribonucleotide nucleotidyltransferase activity
FO454_RS09310	COG0196	riboflavin kinase activity
FO454_RS09320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FO454_RS09325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FO454_RS09330	COG1358	cellular component organization or biogenesis
FO454_RS09335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FO454_RS09340	COG0195	Participates in both transcription termination and antitermination
FO454_RS09345	COG0779	Required for maturation of 30S ribosomal subunits
FO454_RS09350	COG2176	DNA-directed DNA polymerase activity
FO454_RS09355	COG0442	prolyl-tRNA aminoacylation
FO454_RS09370	COG4589	Belongs to the CDS family
FO454_RS09375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FO454_RS09380	COG0233	cytoplasmic translational termination
FO454_RS09385	COG0528	UMP kinase activity
FO454_RS09390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FO454_RS09395	COG0052	Belongs to the universal ribosomal protein uS2 family
FO454_RS09400	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FO454_RS09405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FO454_RS09410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FO454_RS09415	COG4974	Belongs to the 'phage' integrase family
FO454_RS09420	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FO454_RS09425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FO454_RS09430	COG0758	DNA mediated transformation
FO454_RS09435	COG2348	transferase activity, transferring amino-acyl groups
FO454_RS09445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FO454_RS09450	COG0045	succinate-CoA ligase (ADP-forming) activity
FO454_RS09455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO454_RS09465	COG4485	Bacterial membrane protein, YfhO
FO454_RS09475	COG0335	large ribosomal subunit rRNA binding
FO454_RS09480	COG0336	Belongs to the RNA methyltransferase TrmD family
FO454_RS09485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FO454_RS09490	COG0228	four-way junction DNA binding
FO454_RS09505	COG0183	Belongs to the thiolase family
FO454_RS09510	COG0318	PFAM AMP-dependent synthetase and ligase
FO454_RS09515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FO454_RS09520	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FO454_RS09525	COG0552	protein localization to endoplasmic reticulum
FO454_RS09530	COG1196	nuclear chromosome segregation
FO454_RS09535	COG0571	ribonuclease III activity
FO454_RS09540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO454_RS09555	COG0416	fatty acid biosynthetic process
FO454_RS09560	COG1349	DNA-binding transcription factor activity
FO454_RS09565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FO454_RS09570	COG1461	Dihydroxyacetone kinase
FO454_RS09575	COG1302	Protein conserved in bacteria
FO454_RS09580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FO454_RS09590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FO454_RS09605	COG0631	protein serine/threonine phosphatase activity
FO454_RS09615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FO454_RS09615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO454_RS09620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FO454_RS09630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FO454_RS09635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FO454_RS09640	COG1758	RNA polymerase activity
FO454_RS09645	COG0194	GDP metabolic process
FO454_RS09665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FO454_RS09670	COG0284	orotidine-5'-phosphate decarboxylase activity
FO454_RS09680	COG0505	Belongs to the CarA family
FO454_RS09690	COG0540	Belongs to the ATCase OTCase family
FO454_RS09695	COG2233	PERMEase
FO454_RS09700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FO454_RS09705	COG0564	pseudouridine synthase activity
FO454_RS09710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FO454_RS09720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FO454_RS09725	COG3599	regulation of cell shape
FO454_RS09730	COG2302	S4 RNA-binding domain
FO454_RS09735	COG0762	integral membrane protein
FO454_RS09740	COG1799	cell septum assembly
FO454_RS09745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FO454_RS09750	COG1496	oxidoreductase activity
FO454_RS09755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FO454_RS09760	COG0849	cell division
FO454_RS09765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FO454_RS09770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO454_RS09775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO454_RS09780	COG0768	penicillin binding
FO454_RS09785	COG4839	cell division protein FtsL
FO454_RS09790	COG0275	rRNA processing
FO454_RS09800	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FO454_RS09805	COG0454	-acetyltransferase
FO454_RS09815	COG1011	Hydrolase
FO454_RS09825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FO454_RS09830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FO454_RS09835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FO454_RS09840	COG1053	succinate dehydrogenase
FO454_RS09845	COG2009	succinate dehydrogenase
FO454_RS09850	COG0322	excinuclease ABC activity
FO454_RS09855	COG3118	belongs to the thioredoxin family
FO454_RS09860	COG1193	negative regulation of DNA recombination
FO454_RS09865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FO454_RS09865	COG1796	DNA polymerase
FO454_RS09875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FO454_RS09880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO454_RS09885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO454_RS09885	COG0072	phenylalanine-tRNA ligase activity
FO454_RS09890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FO454_RS09895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO454_RS09900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FO454_RS09915	COG1323	Belongs to the UPF0348 family
FO454_RS09920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FO454_RS09925	COG0742	ribosomal rna small subunit methyltransferase
FO454_RS09945	COG3679	Belongs to the UPF0342 family
FO454_RS09960	COG0109	protoheme IX farnesyltransferase activity
FO454_RS09965	COG1612	heme a metabolic process
FO454_RS09980	COG0772	Belongs to the SEDS family
FO454_RS09985	COG4838	Belongs to the UPF0358 family
FO454_RS09990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FO454_RS10000	COG1217	gtp-binding protein TYPA
FO454_RS10010	COG0483	inositol monophosphate 1-phosphatase activity
FO454_RS10015	COG4493	Belongs to the UPF0637 family
FO454_RS10035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FO454_RS10040	COG1177	transmembrane transport
FO454_RS10060	COG4476	Belongs to the UPF0223 family
FO454_RS10075	COG0022	dehydrogenase e1 component
FO454_RS10090	COG0242	peptide deformylase activity
FO454_RS10095	COG5503	Protein of unknown function (DUF1447)
FO454_RS10100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO454_RS10110	COG0569	domain protein
FO454_RS10125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO454_RS10140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FO454_RS10155	COG4172	Belongs to the ABC transporter superfamily
FO454_RS10160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FO454_RS10165	COG0151	Belongs to the GarS family
FO454_RS10170	COG0138	bifunctional purine biosynthesis protein purh
FO454_RS10180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FO454_RS10190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO454_RS10195	COG0047	phosphoribosylformylglycinamidine synthase activity
FO454_RS10200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO454_RS10205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FO454_RS10210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FO454_RS10215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FO454_RS10220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FO454_RS10230	COG1017	nitric oxide dioxygenase activity
FO454_RS10230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FO454_RS10240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FO454_RS10250	COG1845	cytochrome c oxidase, subunit III
FO454_RS10255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FO454_RS10265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FO454_RS10270	COG1316	TRANSCRIPTIONal
FO454_RS10300	COG3594	Acyltransferase
FO454_RS10305	COG0436	Aminotransferase
FO454_RS10310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FO454_RS10315	COG0596	Alpha beta hydrolase
FO454_RS10320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FO454_RS10325	COG1169	isochorismate synthase
FO454_RS10330	COG1575	Belongs to the MenA family. Type 1 subfamily
FO454_RS10385	COG4873	Protein conserved in bacteria
FO454_RS10395	COG0737	Belongs to the 5'-nucleotidase family
FO454_RS10400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FO454_RS10405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO454_RS10405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO454_RS10410	COG0861	Integral membrane protein TerC family
FO454_RS10425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FO454_RS10430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO454_RS10435	COG2814	Major facilitator Superfamily
FO454_RS10440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FO454_RS10445	COG0789	Transcriptional regulator
FO454_RS10450	COG4221	oxidoreductase activity
FO454_RS10460	COG0628	permease
FO454_RS10470	COG0569	domain protein
FO454_RS10470	COG0475	glutathione-regulated potassium exporter activity
FO454_RS10475	COG2239	Acts as a magnesium transporter
FO454_RS10480	COG0564	pseudouridine synthase activity
FO454_RS10490	COG2357	RelA SpoT domain protein
FO454_RS10505	COG2346	COG2346, Truncated hemoglobins
FO454_RS10510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FO454_RS10515	COG1164	Oligoendopeptidase f
FO454_RS10530	COG1393	Belongs to the ArsC family
FO454_RS10535	COG0180	Tryptophanyl-tRNA synthetase
FO454_RS10540	COG2226	methyltransferase
FO454_RS10545	COG4166	transmembrane transport
FO454_RS10550	COG4608	Belongs to the ABC transporter superfamily
FO454_RS10555	COG0444	Belongs to the ABC transporter superfamily
FO454_RS10560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FO454_RS10565	COG0601	transmembrane transport
FO454_RS10580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FO454_RS10590	COG0542	response to heat
FO454_RS10600	COG0561	phosphatase activity
FO454_RS10605	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO454_RS10620	COG1074	ATP-dependent DNA helicase activity
FO454_RS10640	COG0398	Pfam SNARE associated Golgi protein
FO454_RS10645	COG0166	Belongs to the GPI family
FO454_RS10680	COG1902	pentaerythritol trinitrate reductase activity
FO454_RS10685	COG1098	S1 RNA binding domain
FO454_RS10690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FO454_RS10700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO454_RS10700	COG2111	Na H antiporter
FO454_RS10705	COG2111	Na H antiporter
FO454_RS10710	COG1006	Multisubunit Na H antiporter MnhC subunit
FO454_RS10715	COG0651	ATP synthesis coupled electron transport
FO454_RS10720	COG1863	multisubunit Na H antiporter MnhE subunit
FO454_RS10725	COG2212	antiporter activity
FO454_RS10730	COG1320	monovalent cation:proton antiporter activity
FO454_RS10740	COG2050	protein possibly involved in aromatic compounds catabolism
FO454_RS10745	COG2056	Na+-H+ antiporter family
FO454_RS10750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FO454_RS10755	COG1252	NADH dehydrogenase
FO454_RS10765	COG1132	(ABC) transporter
FO454_RS10775	COG1129	ABC transporter
FO454_RS10805	COG3433	isochorismatase activity
FO454_RS10805	COG2226	methyltransferase
FO454_RS10805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO454_RS10810	COG1021	2,3-dihydroxybenzoate-AMP ligase
FO454_RS10825	COG0316	Belongs to the HesB IscA family
FO454_RS10830	COG4844	belongs to the
FO454_RS10835	COG1252	NADH dehydrogenase
FO454_RS10840	COG4837	Protein of unknown function (DUF1462)
FO454_RS10845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FO454_RS10850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FO454_RS10855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO454_RS10860	COG1696	Membrane protein involved in D-alanine export
FO454_RS10865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO454_RS10875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO454_RS10880	COG0647	UMP catabolic process
FO454_RS10885	COG2445	Protein of unknown function DUF86
FO454_RS10895	COG4470	Protein conserved in bacteria
FO454_RS10900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FO454_RS10905	COG0737	Belongs to the 5'-nucleotidase family
FO454_RS10910	COG0730	response to heat
FO454_RS10915	COG1801	Protein of unknown function DUF72
FO454_RS10920	COG2070	2-Nitropropane dioxygenase
FO454_RS10925	COG1253	flavin adenine dinucleotide binding
FO454_RS11040	COG3942	CHAP domain
FO454_RS11040	COG1388	LysM domain
FO454_RS11060	COG0719	Fe-S assembly protein
FO454_RS11065	COG0822	iron-sulfur transferase activity
FO454_RS11075	COG0719	Fe-S assembly protein
FO454_RS11080	COG0396	ATPase activity
FO454_RS11100	COG1464	Belongs to the NlpA lipoprotein family
FO454_RS11105	COG2011	ABC-type metal ion transport system permease component
FO454_RS11110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO454_RS11120	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO454_RS11125	COG0509	glycine decarboxylation via glycine cleavage system
FO454_RS11130	COG1393	Belongs to the ArsC family
FO454_RS11135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO454_RS11145	COG0710	3-dehydroquinate dehydratase activity
FO454_RS11150	COG1764	response to oxidative stress
FO454_RS11160	COG0588	phosphoglycerate mutase activity
FO454_RS11190	COG4195	phage-related replication protein
FO454_RS11205	COG2259	Doxx family
FO454_RS11210	COG0346	lactoylglutathione lyase activity
FO454_RS11225	COG1611	Belongs to the LOG family
FO454_RS11290	COG5484	DNA packaging
FO454_RS11290	COG3728	DNA packaging
FO454_RS11370	COG0582	viral genome integration into host DNA
FO454_RS11390	COG0557	exoribonuclease II activity
FO454_RS11395	COG1647	Serine aminopeptidase, S33
FO454_RS11400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO454_RS11410	COG0148	phosphopyruvate hydratase activity
FO454_RS11415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FO454_RS11420	COG0149	triose-phosphate isomerase activity
FO454_RS11425	COG0126	phosphoglycerate kinase activity
FO454_RS11445	COG1090	epimerase
FO454_RS11450	COG0740	serine-type endopeptidase activity
FO454_RS11455	COG1481	regulation of sporulation
FO454_RS11460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FO454_RS11465	COG1660	Displays ATPase and GTPase activities
FO454_RS11470	COG0492	ferredoxin-NADP+ reductase activity
FO454_RS11485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FO454_RS11490	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FO454_RS11495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FO454_RS11515	COG1388	LysM domain
FO454_RS11515	COG3942	CHAP domain
FO454_RS11525	COG0653	protein targeting
FO454_RS11535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FO454_RS11540	COG1040	competence protein
FO454_RS11545	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FO454_RS11555	COG1739	Uncharacterized protein family UPF0029
FO454_RS11560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO454_RS11565	COG2199	diguanylate cyclase activity
FO454_RS11580	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO454_RS11585	COG1929	Belongs to the glycerate kinase type-1 family
FO454_RS11605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FO454_RS11615	COG4607	ABC-type enterochelin transport system periplasmic component
FO454_RS11620	COG4604	ABC transporter, ATP-binding protein
FO454_RS11625	COG4605	iron ion homeostasis
FO454_RS11630	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS11635	COG4607	ABC-type enterochelin transport system periplasmic component
FO454_RS11640	COG4604	ABC transporter, ATP-binding protein
FO454_RS11645	COG4605	iron ion homeostasis
FO454_RS11650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS11655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO454_RS11660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO454_RS11665	COG1780	Probably involved in ribonucleotide reductase function
FO454_RS11675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FO454_RS11680	COG3104	oligopeptide transport
FO454_RS11685	COG1597	lipid kinase activity
FO454_RS11695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FO454_RS11700	COG3104	oligopeptide transport
FO454_RS11705	COG1174	glycine betaine transport
FO454_RS11715	COG0514	ATP-dependent DNA helicase (RecQ)
FO454_RS11720	COG0488	(ABC) transporter
FO454_RS11730	COG1368	sulfuric ester hydrolase activity
FO454_RS11740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO454_RS11750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO454_RS11750	COG0512	Glutamine amidotransferase of anthranilate synthase
FO454_RS11755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO454_RS11755	COG0512	Glutamine amidotransferase of anthranilate synthase
FO454_RS11765	COG0720	synthase
FO454_RS11780	COG0463	Glycosyl transferase, family 2
FO454_RS11785	COG0656	L-ascorbic acid biosynthetic process
FO454_RS11790	COG1253	flavin adenine dinucleotide binding
FO454_RS11795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO454_RS11795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO454_RS11795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO454_RS11800	COG1105	Belongs to the carbohydrate kinase PfkB family
FO454_RS11805	COG1349	DNA-binding transcription factor activity
FO454_RS11810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FO454_RS11840	COG0415	Belongs to the DNA photolyase family
FO454_RS11845	COG0471	metal ion transport
FO454_RS11850	COG0039	L-malate dehydrogenase activity
FO454_RS11865	COG0523	cobalamin synthesis protein
FO454_RS11875	COG1968	undecaprenyl-diphosphatase activity
FO454_RS11885	COG1671	Belongs to the UPF0178 family
FO454_RS11890	COG1611	Belongs to the LOG family
FO454_RS11920	COG2839	Protein conserved in bacteria
FO454_RS11925	COG2814	Major facilitator Superfamily
FO454_RS11930	COG0583	DNA-binding transcription factor activity
FO454_RS11945	COG0217	transcriptional regulatory protein
FO454_RS11965	COG3942	CHAP domain
FO454_RS11965	COG1388	LysM domain
FO454_RS11970	COG0306	phosphate transporter
FO454_RS11975	COG1392	Phosphate transport regulator
FO454_RS11980	COG0577	efflux transmembrane transporter activity
FO454_RS11985	COG1136	(ABC) transporter
FO454_RS11990	COG2205	protein histidine kinase activity
FO454_RS11995	COG0745	RESPONSE REGULATOR receiver
FO454_RS12000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO454_RS12010	COG0657	acetylesterase activity
FO454_RS12015	COG3949	Membrane
FO454_RS12025	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FO454_RS12030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS12035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS12040	COG1120	ATPase activity
FO454_RS12045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FO454_RS12055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO454_RS12065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS12065	COG0463	Glycosyl transferase, family 2
FO454_RS12070	COG0438	transferase activity, transferring glycosyl groups
FO454_RS12075	COG1132	(ABC) transporter
FO454_RS12080	COG1686	Belongs to the peptidase S11 family
FO454_RS12085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FO454_RS12090	COG1215	transferase activity, transferring glycosyl groups
FO454_RS12095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO454_RS12100	COG1682	transport, permease protein
FO454_RS12105	COG1134	teichoic acid transport
FO454_RS12120	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FO454_RS12130	COG1321	iron dependent repressor
FO454_RS12135	COG1121	(ABC) transporter
FO454_RS12140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO454_RS12145	COG0803	Belongs to the bacterial solute-binding protein 9 family
FO454_RS12155	COG1320	monovalent cation:proton antiporter activity
FO454_RS12160	COG2212	antiporter activity
FO454_RS12165	COG1863	multisubunit Na H antiporter MnhE subunit
FO454_RS12170	COG0651	ATP synthesis coupled electron transport
FO454_RS12175	COG1006	Multisubunit Na H antiporter MnhC subunit
FO454_RS12180	COG2111	Na H antiporter
FO454_RS12185	COG2111	Na H antiporter
FO454_RS12185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO454_RS12190	COG4974	Belongs to the 'phage' integrase family
FO454_RS12220	COG0596	Alpha beta hydrolase
FO454_RS12245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO454_RS12250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO454_RS12270	COG0018	arginyl-trna synthetase
FO454_RS12290	COG1064	alcohol dehydrogenase
FO454_RS12300	COG1078	dGTPase activity
FO454_RS12310	COG0655	NAD(P)H dehydrogenase (quinone) activity
FO454_RS12315	COG0667	Aldo Keto reductase
FO454_RS12325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO454_RS12330	COG1388	LysM domain
FO454_RS12330	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO454_RS12450	COG0756	dUTP diphosphatase activity
FO454_RS12485	COG1484	DNA-dependent DNA replication
FO454_RS12500	COG0629	single-stranded DNA binding
FO454_RS12555	COG3561	AntA/AntB antirepressor
FO454_RS12585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO454_RS12595	COG1447	Phosphotransferase system cellobiose-specific component IIA
FO454_RS12600	COG3684	Belongs to the aldolase LacD family
FO454_RS12605	COG1105	Belongs to the carbohydrate kinase PfkB family
FO454_RS12610	COG0698	ribose 5-phosphate isomerase
FO454_RS12615	COG0698	ribose 5-phosphate isomerase
FO454_RS12620	COG1349	DNA-binding transcription factor activity
FO454_RS12625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FO454_RS12670	COG3682	Transcriptional regulator
FO454_RS12710	COG1309	transcriptional regulator
FO454_RS12720	COG1131	(ABC) transporter
FO454_RS12730	COG1131	(ABC) transporter
FO454_RS12750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FO454_RS12755	COG0101	tRNA pseudouridine synthase activity
FO454_RS12765	COG1122	ATPase activity
FO454_RS12775	COG0203	ribosomal protein L17
FO454_RS12780	COG0202	RNA polymerase activity
FO454_RS12790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FO454_RS12795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FO454_RS12800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FO454_RS12805	COG0563	adenylate kinase activity
FO454_RS12810	COG0201	protein transport
FO454_RS12820	COG1841	ribosomal large subunit assembly
FO454_RS12825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FO454_RS12830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FO454_RS12835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FO454_RS12840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FO454_RS12855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FO454_RS12865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FO454_RS12875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FO454_RS12880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FO454_RS12890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FO454_RS12895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FO454_RS12900	COG0089	rRNA binding
FO454_RS12905	COG0088	Forms part of the polypeptide exit tunnel
FO454_RS12910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FO454_RS12925	COG2252	PERMEase
FO454_RS12950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FO454_RS12955	COG2348	transferase activity, transferring amino-acyl groups
FO454_RS12980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FO454_RS12985	COG0746	molybdenum cofactor guanylyltransferase activity
FO454_RS13020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FO454_RS13025	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FO454_RS13030	COG4149	molybdate abc transporter
FO454_RS13035	COG0725	ABC transporter, periplasmic molybdate-binding protein
FO454_RS13040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FO454_RS13050	COG1268	BioY protein
FO454_RS13060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO454_RS13065	COG1960	acyl-CoA dehydrogenase activity