locus-tag	class	description
FO456_RS00010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FO456_RS00095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FO456_RS00105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FO456_RS00110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FO456_RS00120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO456_RS00130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FO456_RS00145	COG1098	S1 RNA binding domain
FO456_RS00155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FO456_RS00160	COG3956	TIGRFAM MazG family protein
FO456_RS00165	COG2244	polysaccharide biosynthetic process
FO456_RS00170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FO456_RS00175	COG0193	aminoacyl-tRNA hydrolase activity
FO456_RS00185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FO456_RS00190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FO456_RS00200	COG0251	oxidation-reduction process
FO456_RS00205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO456_RS00210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FO456_RS00215	COG4466	Protein conserved in bacteria
FO456_RS00220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FO456_RS00225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO456_RS00230	COG0084	hydrolase, TatD family'
FO456_RS00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO456_RS00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO456_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FO456_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FO456_RS00260	COG1774	PSP1 C-terminal conserved region
FO456_RS00265	COG0470	DNA polymerase III
FO456_RS00270	COG3870	Protein conserved in bacteria
FO456_RS00275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FO456_RS00280	COG1982	Orn Lys Arg decarboxylase major
FO456_RS00310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FO456_RS00320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FO456_RS00335	COG2188	Transcriptional regulator
FO456_RS00340	COG0366	Alpha amylase catalytic
FO456_RS00345	COG1263	PTS System
FO456_RS00345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS00355	COG0493	'glutamate synthase
FO456_RS00360	COG0069	glutamate synthase activity
FO456_RS00360	COG0067	glutamate synthase
FO456_RS00360	COG0070	glutamate synthase
FO456_RS00365	COG0583	DNA-binding transcription factor activity
FO456_RS00395	COG1464	Belongs to the NlpA lipoprotein family
FO456_RS00400	COG2011	ABC-type metal ion transport system permease component
FO456_RS00405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO456_RS00410	COG1132	(ABC) transporter
FO456_RS00415	COG1132	(ABC) transporter
FO456_RS00415	COG2375	cellular response to nickel ion
FO456_RS00420	COG0626	cystathionine gamma-synthase activity
FO456_RS00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FO456_RS00435	COG0733	neurotransmitter:sodium symporter activity
FO456_RS00455	COG5609	conserved protein (DUF2294)
FO456_RS00460	COG3002	Belongs to the UPF0753 family
FO456_RS00465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO456_RS00475	COG0523	cobalamin synthesis protein
FO456_RS00495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FO456_RS00495	COG0519	Catalyzes the synthesis of GMP from XMP
FO456_RS00500	COG0517	IMP dehydrogenase activity
FO456_RS00500	COG0516	GMP reductase activity
FO456_RS00505	COG2233	PERMEase
FO456_RS00510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FO456_RS00530	COG1823	symporter activity
FO456_RS00535	COG0778	Nitroreductase
FO456_RS00545	COG0450	alkyl hydroperoxide reductase
FO456_RS00550	COG3634	alkyl hydroperoxide reductase activity
FO456_RS00565	COG0588	phosphoglycerate mutase activity
FO456_RS00605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FO456_RS00615	COG0360	Binds together with S18 to 16S ribosomal RNA
FO456_RS00630	COG0012	GTP binding
FO456_RS00635	COG4481	Protein conserved in bacteria
FO456_RS00640	COG0668	transmembrane transport
FO456_RS00645	COG1475	DNA binding
FO456_RS00650	COG0626	cystathionine gamma-synthase activity
FO456_RS00655	COG0626	cystathionine gamma-synthase activity
FO456_RS00660	COG0646	methionine synthase
FO456_RS00660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FO456_RS00665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FO456_RS00690	COG0577	efflux transmembrane transporter activity
FO456_RS00695	COG1136	(ABC) transporter
FO456_RS00715	COG2205	protein histidine kinase activity
FO456_RS00730	COG0745	RESPONSE REGULATOR receiver
FO456_RS00760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FO456_RS00765	COG2271	Major facilitator Superfamily
FO456_RS00780	COG1136	(ABC) transporter
FO456_RS00785	COG0577	efflux transmembrane transporter activity
FO456_RS00795	COG1396	sequence-specific DNA binding
FO456_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS00820	COG1063	alcohol dehydrogenase
FO456_RS00840	COG1475	DNA binding
FO456_RS00850	COG0445	tRNA wobble uridine modification
FO456_RS00855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FO456_RS00860	COG0594	ribonuclease P activity
FO456_RS00870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FO456_RS00875	COG0592	DNA-directed DNA polymerase activity
FO456_RS00880	COG2501	S4 domain
FO456_RS00885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FO456_RS00890	COG0187	DNA topoisomerase II activity
FO456_RS00895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO456_RS00900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FO456_RS00910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FO456_RS00920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FO456_RS00930	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FO456_RS00935	COG0359	binds to the 23S rRNA
FO456_RS00940	COG0305	Participates in initiation and elongation during chromosome replication
FO456_RS00945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FO456_RS00960	COG0745	RESPONSE REGULATOR receiver
FO456_RS00965	COG5002	protein histidine kinase activity
FO456_RS00970	COG4863	YycH protein
FO456_RS01005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FO456_RS01010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FO456_RS01020	COG1522	sequence-specific DNA binding
FO456_RS01050	COG1073	alpha beta
FO456_RS01080	COG1129	ABC transporter
FO456_RS01120	COG0745	RESPONSE REGULATOR receiver
FO456_RS01135	COG1131	(ABC) transporter
FO456_RS01200	COG2188	Transcriptional regulator
FO456_RS01205	COG2222	sugar isomerase
FO456_RS01215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS01220	COG3715	PTS system
FO456_RS01225	COG3716	PTS system mannose fructose sorbose family IID component
FO456_RS01235	COG0745	RESPONSE REGULATOR receiver
FO456_RS01240	COG2205	protein histidine kinase activity
FO456_RS01250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FO456_RS01255	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FO456_RS01280	COG1129	ABC transporter
FO456_RS01315	COG4509	Sortase family
FO456_RS01325	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO456_RS01325	COG3942	CHAP domain
FO456_RS01330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS01335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS01340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO456_RS01345	COG2808	Putative FMN-binding domain
FO456_RS01355	COG1846	Transcriptional regulator
FO456_RS01370	COG3842	ATPase activity
FO456_RS01375	COG4209	transmembrane transport
FO456_RS01385	COG0395	ABC-type sugar transport system, permease component
FO456_RS01395	COG0534	Mate efflux family protein
FO456_RS01400	COG1349	DNA-binding transcription factor activity
FO456_RS01410	COG5002	protein histidine kinase activity
FO456_RS01445	COG0583	DNA-binding transcription factor activity
FO456_RS01450	COG3842	ATPase activity
FO456_RS01455	COG1840	ABC-type Fe3 transport system, periplasmic component
FO456_RS01460	COG1177	transmembrane transport
FO456_RS01465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FO456_RS01470	COG1414	Transcriptional regulator
FO456_RS01480	COG0800	Aldolase
FO456_RS01485	COG4948	Mandelate Racemase Muconate Lactonizing
FO456_RS01490	COG2610	gluconate transmembrane transporter activity
FO456_RS01505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FO456_RS01515	COG1114	Component of the transport system for branched-chain amino acids
FO456_RS01525	COG0464	growth
FO456_RS01530	COG0561	phosphatase activity
FO456_RS01535	COG2814	Major facilitator Superfamily
FO456_RS01550	COG0601	transmembrane transport
FO456_RS01560	COG0444	Belongs to the ABC transporter superfamily
FO456_RS01565	COG1124	(ABC) transporter
FO456_RS01580	COG0693	protein deglycase activity
FO456_RS01585	COG0531	amino acid
FO456_RS01595	COG0505	Belongs to the CarA family
FO456_RS01600	COG0657	acetylesterase activity
FO456_RS01640	COG1033	growth of symbiont in host cell
FO456_RS01640	COG2409	Drug exporters of the RND superfamily
FO456_RS01660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FO456_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS01685	COG1278	Cold shock
FO456_RS01700	COG2311	Membrane
FO456_RS01705	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FO456_RS01715	COG1233	COG1233 Phytoene dehydrogenase and related
FO456_RS01735	COG2814	Major facilitator Superfamily
FO456_RS01750	COG1131	(ABC) transporter
FO456_RS01775	COG2264	protein methyltransferase activity
FO456_RS01780	COG0747	negative chemotaxis
FO456_RS01785	COG0601	transmembrane transport
FO456_RS01795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO456_RS01800	COG1124	(ABC) transporter
FO456_RS01805	COG3961	Belongs to the TPP enzyme family
FO456_RS01820	COG1131	(ABC) transporter
FO456_RS01830	COG2353	YceI-like domain
FO456_RS01835	COG1288	antiporter activity
FO456_RS01845	COG2814	Major facilitator Superfamily
FO456_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS01875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS01875	COG1263	PTS System
FO456_RS01875	COG2190	(PTS) system
FO456_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS01905	COG1053	succinate dehydrogenase
FO456_RS01905	COG3976	FMN-binding domain protein
FO456_RS01905	COG0431	NADPH-dependent FMN reductase
FO456_RS01930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO456_RS01935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO456_RS01940	COG0022	dehydrogenase e1 component
FO456_RS01950	COG1695	Transcriptional regulator
FO456_RS01970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS01970	COG3711	transcriptional antiterminator
FO456_RS01975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO456_RS01975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS01975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO456_RS01980	COG1482	cell wall glycoprotein biosynthetic process
FO456_RS01995	COG1846	Transcriptional regulator
FO456_RS02000	COG2814	Major facilitator Superfamily
FO456_RS02025	COG0706	membrane insertase activity
FO456_RS02035	COG0531	amino acid
FO456_RS02090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO456_RS02110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FO456_RS02120	COG0363	glucosamine-6-phosphate deaminase activity
FO456_RS02125	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FO456_RS02140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO456_RS02145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FO456_RS02155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO456_RS02190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FO456_RS02210	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FO456_RS02215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS02215	COG3711	transcriptional antiterminator
FO456_RS02220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS02230	COG3037	sugar-specific permease SgaT UlaA
FO456_RS02235	COG1054	Belongs to the UPF0176 family
FO456_RS02240	COG3386	PFAM SMP-30 Gluconolaconase
FO456_RS02255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO456_RS02265	COG1122	ATPase activity
FO456_RS02275	COG1476	TRANSCRIPTIONal
FO456_RS02310	COG3942	CHAP domain
FO456_RS02310	COG1705	Flagellar rod assembly protein muramidase FlgJ
FO456_RS02335	COG2235	arginine
FO456_RS02345	COG2843	Capsule synthesis protein
FO456_RS02350	COG4195	phage-related replication protein
FO456_RS02395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO456_RS02420	COG0297	glycogen (starch) synthase activity
FO456_RS02430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FO456_RS02435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FO456_RS02440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FO456_RS02445	COG1785	Belongs to the alkaline phosphatase family
FO456_RS02455	COG0745	RESPONSE REGULATOR receiver
FO456_RS02460	COG2205	protein histidine kinase activity
FO456_RS02465	COG1136	(ABC) transporter
FO456_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS02510	COG0175	sulfate reduction
FO456_RS02515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FO456_RS02520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO456_RS02535	COG0730	response to heat
FO456_RS02540	COG2046	Belongs to the sulfate adenylyltransferase family
FO456_RS02545	COG0529	Catalyzes the synthesis of activated sulfate
FO456_RS02560	COG1328	CTP reductase activity
FO456_RS02565	COG0602	queuosine metabolic process
FO456_RS02570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FO456_RS02580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO456_RS02585	COG1510	regulation of RNA biosynthetic process
FO456_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
FO456_RS02595	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FO456_RS02600	COG1473	amidohydrolase
FO456_RS02615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO456_RS02620	COG0574	Belongs to the PEP-utilizing enzyme family
FO456_RS02620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO456_RS02625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO456_RS02635	COG2188	Transcriptional regulator
FO456_RS02640	COG2190	(PTS) system
FO456_RS02640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS02640	COG1263	PTS System
FO456_RS02645	COG2723	6-phospho-beta-galactosidase activity
FO456_RS02655	COG0583	DNA-binding transcription factor activity
FO456_RS02670	COG3588	fructose-bisphosphate aldolase
FO456_RS02685	COG1464	Belongs to the NlpA lipoprotein family
FO456_RS02695	COG0463	Glycosyl transferase, family 2
FO456_RS02705	COG1215	transferase activity, transferring glycosyl groups
FO456_RS02705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS02715	COG0531	amino acid
FO456_RS02720	COG0583	DNA-binding transcription factor activity
FO456_RS02725	COG0028	Belongs to the TPP enzyme family
FO456_RS02730	COG3527	Alpha-acetolactate decarboxylase
FO456_RS02735	COG1620	l-lactate permease
FO456_RS02755	COG0167	dihydroorotate dehydrogenase activity
FO456_RS02760	COG3001	Fructosamine kinase
FO456_RS02765	COG0596	Alpha beta hydrolase
FO456_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS02815	COG2814	Major facilitator Superfamily
FO456_RS02825	COG1113	amino acid transport
FO456_RS02840	COG3189	MarR family transcriptional regulator
FO456_RS02860	COG0436	Aminotransferase
FO456_RS02870	COG2608	mercury ion transmembrane transporter activity
FO456_RS02875	COG2217	Heavy metal translocating P-type atpase
FO456_RS02885	COG0110	maltose O-acetyltransferase activity
FO456_RS02890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS02895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO456_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
FO456_RS02920	COG0598	Magnesium transport protein CorA
FO456_RS02925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FO456_RS02950	COG1131	(ABC) transporter
FO456_RS02960	COG3425	synthase
FO456_RS02975	COG1388	LysM domain
FO456_RS02975	COG3942	CHAP domain
FO456_RS02985	COG0583	DNA-binding transcription factor activity
FO456_RS02990	COG1380	Effector of murein hydrolase LrgA
FO456_RS02995	COG1346	cytolysis
FO456_RS03000	COG0028	Belongs to the TPP enzyme family
FO456_RS03015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO456_RS03020	COG0039	L-malate dehydrogenase activity
FO456_RS03025	COG0657	acetylesterase activity
FO456_RS03035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO456_RS03055	COG1070	Carbohydrate kinase
FO456_RS03065	COG1760	l-serine dehydratase
FO456_RS03070	COG1760	l-serine dehydratase
FO456_RS03080	COG3764	Sortase (surface protein transpeptidase)
FO456_RS03090	COG0561	phosphatase activity
FO456_RS03095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO456_RS03100	COG0778	Nitroreductase
FO456_RS03110	COG1012	belongs to the aldehyde dehydrogenase family
FO456_RS03115	COG2514	catechol 2,3-dioxygenase activity
FO456_RS03120	COG2388	GCN5-related N-acetyl-transferase
FO456_RS03155	COG1846	Transcriptional regulator
FO456_RS03160	COG0346	lactoylglutathione lyase activity
FO456_RS03165	COG0346	lactoylglutathione lyase activity
FO456_RS03170	COG0400	carboxylic ester hydrolase activity
FO456_RS03175	COG3949	Membrane
FO456_RS03185	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FO456_RS03190	COG1733	regulation of RNA biosynthetic process
FO456_RS03200	COG1902	pentaerythritol trinitrate reductase activity
FO456_RS03205	COG0586	Pfam SNARE associated Golgi protein
FO456_RS03215	COG2022	thiamine diphosphate biosynthetic process
FO456_RS03235	COG2271	Major facilitator Superfamily
FO456_RS03250	COG4876	unkown
FO456_RS03255	COG2357	RelA SpoT domain protein
FO456_RS03270	COG1802	Transcriptional regulator
FO456_RS03275	COG1070	Carbohydrate kinase
FO456_RS03280	COG2610	gluconate transmembrane transporter activity
FO456_RS03285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FO456_RS03300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FO456_RS03305	COG0438	transferase activity, transferring glycosyl groups
FO456_RS03325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO456_RS03340	COG4221	oxidoreductase activity
FO456_RS03345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO456_RS03350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FO456_RS03360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FO456_RS03365	COG1363	Peptidase, m42
FO456_RS03385	COG3639	organic phosphonate transmembrane transporter activity
FO456_RS03390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FO456_RS03405	COG0737	Belongs to the 5'-nucleotidase family
FO456_RS03410	COG0069	glutamate synthase activity
FO456_RS03425	COG4619	ABC transporter
FO456_RS03430	COG0390	transport system, permease component
FO456_RS03435	COG2205	protein histidine kinase activity
FO456_RS03440	COG0745	RESPONSE REGULATOR receiver
FO456_RS03450	COG2814	Major facilitator Superfamily
FO456_RS03455	COG2272	Belongs to the type-B carboxylesterase lipase family
FO456_RS03460	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FO456_RS03465	COG1063	alcohol dehydrogenase
FO456_RS03485	COG1174	glycine betaine transport
FO456_RS03515	COG1346	cytolysis
FO456_RS03520	COG1380	Effector of murein hydrolase LrgA
FO456_RS03525	COG3279	Response regulator of the LytR AlgR family
FO456_RS03530	COG3275	phosphorelay sensor kinase activity
FO456_RS03540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FO456_RS03555	COG0706	membrane insertase activity
FO456_RS03565	COG0531	amino acid
FO456_RS03580	COG1113	amino acid transport
FO456_RS03600	COG2814	Major facilitator Superfamily
FO456_RS03610	COG1929	Belongs to the glycerate kinase type-1 family
FO456_RS03620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FO456_RS03625	COG0741	lytic transglycosylase activity
FO456_RS03630	COG0588	phosphoglycerate mutase activity
FO456_RS03640	COG2814	Major facilitator Superfamily
FO456_RS03645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FO456_RS03650	COG0765	amino acid transport
FO456_RS03655	COG1126	abc transporter atp-binding protein
FO456_RS03695	COG1131	(ABC) transporter
FO456_RS03705	COG2116	formate transmembrane transporter activity
FO456_RS03715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FO456_RS03720	COG2146	nitrite reductase [NAD(P)H] activity
FO456_RS03730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FO456_RS03735	COG1140	nitrate reductase beta subunit
FO456_RS03745	COG2181	nitrate reductase activity
FO456_RS03755	COG4585	Histidine kinase
FO456_RS03765	COG2223	nitrite transmembrane transporter activity
FO456_RS03770	COG1846	Transcriptional regulator
FO456_RS03810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS03810	COG1263	PTS System
FO456_RS03835	COG0534	Mate efflux family protein
FO456_RS03845	COG1124	(ABC) transporter
FO456_RS03850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO456_RS03860	COG0601	transmembrane transport
FO456_RS03870	COG0829	nickel cation binding
FO456_RS03885	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FO456_RS03890	COG0804	urea catabolic process
FO456_RS03900	COG0831	urea catabolic process
FO456_RS03905	COG4413	Urea transporter
FO456_RS03915	COG4716	Myosin-crossreactive antigen
FO456_RS03920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FO456_RS03925	COG2962	Rard protein
FO456_RS03940	COG0488	(ABC) transporter
FO456_RS03965	COG2814	Major facilitator Superfamily
FO456_RS03970	COG0583	DNA-binding transcription factor activity
FO456_RS04010	COG2314	TM2 domain
FO456_RS04015	COG0492	ferredoxin-NADP+ reductase activity
FO456_RS04030	COG0604	alcohol dehydrogenase
FO456_RS04035	COG2822	iron ion transport
FO456_RS04040	COG2837	iron assimilation
FO456_RS04045	COG0672	)-iron permease
FO456_RS04050	COG0805	protein transport
FO456_RS04055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FO456_RS04060	COG0456	acetyltransferase
FO456_RS04070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS04075	COG1620	l-lactate permease
FO456_RS04080	COG0297	glycogen (starch) synthase activity
FO456_RS04085	COG0579	oxidoreductase
FO456_RS04135	COG2814	Major facilitator Superfamily
FO456_RS04145	COG1566	PFAM secretion protein HlyD family protein
FO456_RS04150	COG2814	Major facilitator Superfamily
FO456_RS04180	COG0598	Magnesium transport protein CorA
FO456_RS04185	COG1304	FMN binding
FO456_RS04190	COG2094	Belongs to the DNA glycosylase MPG family
FO456_RS04200	COG2017	converts alpha-aldose to the beta-anomer
FO456_RS04205	COG2258	MOSC domain
FO456_RS04210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FO456_RS04215	COG1266	CAAX protease self-immunity
FO456_RS04225	COG1473	amidohydrolase
FO456_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
FO456_RS04250	COG1737	Transcriptional regulator
FO456_RS04255	COG1263	PTS System
FO456_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS04265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FO456_RS04285	COG1113	amino acid transport
FO456_RS04290	COG1737	Transcriptional regulator
FO456_RS04295	COG1263	PTS System
FO456_RS04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS04300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FO456_RS04310	COG1349	DNA-binding transcription factor activity
FO456_RS04320	COG1316	TRANSCRIPTIONal
FO456_RS04345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO456_RS04350	COG2076	Multidrug Resistance protein
FO456_RS04360	COG3942	CHAP domain
FO456_RS04375	COG1757	Na H antiporter
FO456_RS04380	COG3942	CHAP domain
FO456_RS04410	COG1960	acyl-CoA dehydrogenase activity
FO456_RS04415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO456_RS04425	COG1268	BioY protein
FO456_RS04435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FO456_RS04440	COG0725	ABC transporter, periplasmic molybdate-binding protein
FO456_RS04445	COG4149	molybdate abc transporter
FO456_RS04450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FO456_RS04455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FO456_RS04490	COG0746	molybdenum cofactor guanylyltransferase activity
FO456_RS04495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FO456_RS04520	COG2348	transferase activity, transferring amino-acyl groups
FO456_RS04525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FO456_RS04550	COG2252	PERMEase
FO456_RS04565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FO456_RS04570	COG0088	Forms part of the polypeptide exit tunnel
FO456_RS04575	COG0089	rRNA binding
FO456_RS04580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FO456_RS04585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FO456_RS04595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FO456_RS04600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FO456_RS04610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FO456_RS04620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FO456_RS04635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FO456_RS04640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FO456_RS04645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FO456_RS04650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FO456_RS04655	COG1841	ribosomal large subunit assembly
FO456_RS04665	COG0201	protein transport
FO456_RS04670	COG0563	adenylate kinase activity
FO456_RS04675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FO456_RS04680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FO456_RS04685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FO456_RS04695	COG0202	RNA polymerase activity
FO456_RS04700	COG0203	ribosomal protein L17
FO456_RS04710	COG1122	ATPase activity
FO456_RS04720	COG0101	tRNA pseudouridine synthase activity
FO456_RS04725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FO456_RS04745	COG1131	(ABC) transporter
FO456_RS04755	COG1131	(ABC) transporter
FO456_RS04765	COG1309	transcriptional regulator
FO456_RS04805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FO456_RS04810	COG1349	DNA-binding transcription factor activity
FO456_RS04815	COG0698	ribose 5-phosphate isomerase
FO456_RS04820	COG0698	ribose 5-phosphate isomerase
FO456_RS04825	COG1105	Belongs to the carbohydrate kinase PfkB family
FO456_RS04830	COG3684	Belongs to the aldolase LacD family
FO456_RS04835	COG1447	Phosphotransferase system cellobiose-specific component IIA
FO456_RS04840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FO456_RS04840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FO456_RS04845	COG2723	6-phospho-beta-galactosidase activity
FO456_RS04855	COG2130	NADP-dependent
FO456_RS04860	COG0604	alcohol dehydrogenase
FO456_RS04890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FO456_RS04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS04900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS04905	COG3314	Sporulation integral membrane protein YlbJ
FO456_RS04915	COG1988	membrane-bound metal-dependent
FO456_RS04920	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FO456_RS04925	COG1272	protein, Hemolysin III
FO456_RS04940	COG2814	Major facilitator Superfamily
FO456_RS04945	COG0489	protein tyrosine kinase activity
FO456_RS05015	COG0561	phosphatase activity
FO456_RS05035	COG0640	Transcriptional regulator
FO456_RS05040	COG0702	epimerase
FO456_RS05045	COG1482	cell wall glycoprotein biosynthetic process
FO456_RS05065	COG0783	Belongs to the Dps family
FO456_RS05070	COG0813	purine-nucleoside phosphorylase activity
FO456_RS05075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FO456_RS05080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FO456_RS05085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FO456_RS05115	COG1854	S-ribosylhomocysteine lyase activity
FO456_RS05135	COG5146	pantothenate kinase activity
FO456_RS05145	COG3343	RNA polymerase activity
FO456_RS05150	COG0504	CTP synthase activity
FO456_RS05160	COG0191	fructose-bisphosphate aldolase activity
FO456_RS05165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO456_RS05175	COG1012	belongs to the aldehyde dehydrogenase family
FO456_RS05180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FO456_RS05185	COG0254	rRNA binding
FO456_RS05195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FO456_RS05200	COG2890	protein-(glutamine-N5) methyltransferase activity
FO456_RS05205	COG0009	L-threonylcarbamoyladenylate synthase
FO456_RS05210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO456_RS05215	COG4475	Protein of unknown function (DUF436)
FO456_RS05220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FO456_RS05235	COG0356	it plays a direct role in the translocation of protons across the membrane
FO456_RS05240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FO456_RS05245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FO456_RS05260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FO456_RS05265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FO456_RS05275	COG4836	Membrane
FO456_RS05280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FO456_RS05285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FO456_RS05295	COG0629	single-stranded DNA binding
FO456_RS05305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FO456_RS05315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FO456_RS05320	COG0352	thiamine-phosphate diphosphorylase activity
FO456_RS05325	COG0706	membrane insertase activity
FO456_RS05330	COG1418	mRNA catabolic process
FO456_RS05335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO456_RS05340	COG1937	Protein conserved in bacteria
FO456_RS05355	COG0772	Belongs to the SEDS family
FO456_RS05360	COG1181	Belongs to the D-alanine--D-alanine ligase family
FO456_RS05365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FO456_RS05370	COG0513	Belongs to the DEAD box helicase family
FO456_RS05380	COG3428	Bacterial PH domain
FO456_RS05390	COG0736	holo-[acyl-carrier-protein] synthase activity
FO456_RS05405	COG2337	Toxic component of a toxin-antitoxin (TA) module
FO456_RS05410	COG2208	phosphoserine phosphatase activity
FO456_RS05425	COG1191	sigma factor activity
FO456_RS05430	COG2183	response to ionizing radiation
FO456_RS05470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FO456_RS05475	COG0066	3-isopropylmalate dehydratase activity
FO456_RS05480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FO456_RS05490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FO456_RS05495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FO456_RS05505	COG0028	Belongs to the TPP enzyme family
FO456_RS05515	COG0802	atpase or kinase
FO456_RS05520	COG1214	PFAM Peptidase M22, glycoprotease
FO456_RS05525	COG0456	acetyltransferase
FO456_RS05530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FO456_RS05535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO456_RS05540	COG0488	(ABC) transporter
FO456_RS05545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FO456_RS05550	COG2391	methyltransferase activity
FO456_RS05555	COG0425	Belongs to the sulfur carrier protein TusA family
FO456_RS05560	COG0004	ammonium transporteR
FO456_RS05565	COG1609	Transcriptional regulator
FO456_RS05570	COG1621	beta-fructofuranosidase activity
FO456_RS05575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FO456_RS05585	COG3290	protein histidine kinase activity
FO456_RS05595	COG4512	PFAM Accessory gene regulator B
FO456_RS05600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FO456_RS05625	COG0459	protein refolding
FO456_RS05630	COG0436	Aminotransferase
FO456_RS05640	COG1725	Transcriptional regulator
FO456_RS05645	COG1129	ABC transporter
FO456_RS05645	COG0842	Transport permease protein
FO456_RS05655	COG1131	(ABC) transporter
FO456_RS05695	COG2706	6-phosphogluconolactonase activity
FO456_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
FO456_RS05705	COG1227	inorganic diphosphatase activity
FO456_RS05710	COG1335	isochorismatase
FO456_RS05725	COG0077	Prephenate dehydratase
FO456_RS05735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FO456_RS05740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FO456_RS05745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FO456_RS05755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FO456_RS05760	COG4496	protein, YerC YecD
FO456_RS05765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FO456_RS05775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FO456_RS05780	COG4851	CamS sex pheromone cAM373 precursor
FO456_RS05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FO456_RS05800	COG0154	amidase activity
FO456_RS05805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FO456_RS05810	COG1597	lipid kinase activity
FO456_RS05815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FO456_RS05840	COG1528	Iron-storage protein
FO456_RS05860	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO456_RS05865	COG4129	membrane
FO456_RS05870	COG0024	Methionine aminopeptidase
FO456_RS05895	COG1295	ribonuclease BN
FO456_RS05905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FO456_RS05910	COG4840	Belongs to the UPF0435 family
FO456_RS05915	COG2309	aminopeptidase activity
FO456_RS05920	COG1607	acyl-coa hydrolase
FO456_RS05925	COG0535	radical SAM domain protein
FO456_RS05935	COG0693	protein deglycase activity
FO456_RS05940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO456_RS05945	COG2137	regulation of response to DNA damage stimulus
FO456_RS05955	COG1388	LysM domain
FO456_RS05955	COG1134	teichoic acid transport
FO456_RS05965	COG1988	membrane-bound metal-dependent
FO456_RS05970	COG1194	a g-specific adenine glycosylase
FO456_RS05975	COG3557	Belongs to the UPF0374 family
FO456_RS05985	COG4129	membrane
FO456_RS05990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO456_RS05995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FO456_RS06005	COG0735	belongs to the Fur family
FO456_RS06165	COG0765	amino acid transport
FO456_RS06170	COG1126	abc transporter atp-binding protein
FO456_RS06175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FO456_RS06185	COG0363	glucosamine-6-phosphate deaminase activity
FO456_RS06200	COG0114	fumarate hydratase activity
FO456_RS06205	COG0564	pseudouridine synthase activity
FO456_RS06210	COG2203	Gaf domain
FO456_RS06210	COG4585	Histidine kinase
FO456_RS06215	COG2197	response regulator
FO456_RS06230	COG3679	Belongs to the UPF0342 family
FO456_RS06235	COG0420	3'-5' exonuclease activity
FO456_RS06260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FO456_RS06275	COG0537	adenosine 5'-monophosphoramidase activity
FO456_RS06280	COG1131	(ABC) transporter
FO456_RS06285	COG4473	ABC transporter
FO456_RS06290	COG2329	Antibiotic biosynthesis monooxygenase
FO456_RS06295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FO456_RS06305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FO456_RS06310	COG3545	Serine hydrolase
FO456_RS06360	COG0318	PFAM AMP-dependent synthetase and ligase
FO456_RS06370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FO456_RS06380	COG1506	peptidase
FO456_RS06385	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FO456_RS06390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FO456_RS06400	COG0656	L-ascorbic acid biosynthetic process
FO456_RS06405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FO456_RS06420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FO456_RS06445	COG5632	N-Acetylmuramoyl-L-alanine amidase
FO456_RS06445	COG3266	domain, Protein
FO456_RS06445	COG4193	domain, Protein
FO456_RS06455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO456_RS06455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FO456_RS06465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO456_RS06465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FO456_RS06470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FO456_RS06475	COG0506	proline dehydrogenase activity
FO456_RS06480	COG2267	carboxylic ester hydrolase activity
FO456_RS06490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FO456_RS06495	COG1242	4 iron, 4 sulfur cluster binding
FO456_RS06500	COG2814	Major facilitator Superfamily
FO456_RS06505	COG0495	leucyl-tRNA aminoacylation
FO456_RS06515	COG2081	HI0933 family
FO456_RS06520	COG2244	polysaccharide biosynthetic process
FO456_RS06525	COG1187	pseudouridine synthase activity
FO456_RS06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FO456_RS06545	COG0510	thiamine kinase activity
FO456_RS06550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FO456_RS06555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO456_RS06560	COG5584	Small secreted protein
FO456_RS06565	COG1363	Peptidase, m42
FO456_RS06570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO456_RS06575	COG4848	Belongs to the UPF0354 family
FO456_RS06580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO456_RS06585	COG1674	ftsk spoiiie
FO456_RS06590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FO456_RS06595	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FO456_RS06605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FO456_RS06605	COG1605	Chorismate mutase
FO456_RS06610	COG1609	Transcriptional regulator
FO456_RS06625	COG0123	including yeast histone deacetylase and acetoin utilization protein
FO456_RS06630	COG0454	-acetyltransferase
FO456_RS06635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FO456_RS06640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FO456_RS06650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FO456_RS06655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO456_RS06660	COG0204	Acyl-transferase
FO456_RS06665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FO456_RS06665	COG1263	PTS System
FO456_RS06675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FO456_RS06680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FO456_RS06685	COG1764	response to oxidative stress
FO456_RS06690	COG0584	glycerophosphoryl diester phosphodiesterase
FO456_RS06695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FO456_RS06705	COG1956	GAF domain-containing protein
FO456_RS06710	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FO456_RS06715	COG1104	cysteine desulfurase activity
FO456_RS06720	COG0301	tRNA thio-modification
FO456_RS06725	COG0730	response to heat
FO456_RS06730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FO456_RS06735	COG0827	DNA restriction-modification system
FO456_RS06740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FO456_RS06745	COG0589	response to stress
FO456_RS06750	COG0686	Belongs to the AlaDH PNT family
FO456_RS06755	COG0006	proline dipeptidase activity
FO456_RS06760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FO456_RS06770	COG4109	DRTGG domain
FO456_RS06775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FO456_RS06780	COG0587	DNA-directed DNA polymerase activity
FO456_RS06785	COG0281	malic enzyme
FO456_RS06790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FO456_RS06795	COG0825	malonyl-CoA metabolic process
FO456_RS06800	COG0205	6-phosphofructokinase activity
FO456_RS06805	COG0469	pyruvate kinase activity
FO456_RS06810	COG1113	amino acid transport
FO456_RS06815	COG0372	Belongs to the citrate synthase family
FO456_RS06820	COG0538	isocitrate dehydrogenase activity
FO456_RS06825	COG0745	RESPONSE REGULATOR receiver
FO456_RS06830	COG5002	protein histidine kinase activity
FO456_RS06835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO456_RS06835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO456_RS06840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FO456_RS06845	COG0237	dephospho-CoA kinase activity
FO456_RS06850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FO456_RS06855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FO456_RS06860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FO456_RS06865	COG3611	Membrane attachment protein
FO456_RS06870	COG1484	DNA-dependent DNA replication
FO456_RS06880	COG0833	amino acid
FO456_RS06885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FO456_RS06890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FO456_RS06895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FO456_RS06900	COG4112	unkown
FO456_RS06910	COG0544	peptidyl-prolyl cis-trans isomerase activity
FO456_RS06915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FO456_RS06930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FO456_RS06935	COG0181	hydroxymethylbilane synthase activity
FO456_RS06950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FO456_RS06960	COG2818	Glycosylase
FO456_RS06965	COG0525	valine-tRNA ligase activity
FO456_RS06970	COG0285	dihydrofolate synthase activity
FO456_RS06980	COG2003	Belongs to the UPF0758 family
FO456_RS06995	COG1792	Involved in formation and maintenance of cell shape
FO456_RS07005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FO456_RS07010	COG2868	ribosomal protein
FO456_RS07020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FO456_RS07025	COG4492	Belongs to the UPF0735 family
FO456_RS07030	COG0632	four-way junction helicase activity
FO456_RS07035	COG2255	four-way junction helicase activity
FO456_RS07040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FO456_RS07045	COG0343	queuine tRNA-ribosyltransferase activity
FO456_RS07050	COG1862	Preprotein translocase
FO456_RS07055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO456_RS07055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FO456_RS07060	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FO456_RS07060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FO456_RS07070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FO456_RS07075	COG1490	D-aminoacyl-tRNA deacylase activity
FO456_RS07080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO456_RS07085	COG0124	histidyl-tRNA synthetase
FO456_RS07090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FO456_RS07100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FO456_RS07105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FO456_RS07110	COG1959	2 iron, 2 sulfur cluster binding
FO456_RS07120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FO456_RS07125	COG1104	cysteine desulfurase activity
FO456_RS07130	COG0482	sulfurtransferase activity
FO456_RS07140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FO456_RS07145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FO456_RS07150	COG4472	Bacterial protein of unknown function (DUF965)
FO456_RS07155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FO456_RS07165	COG4122	O-methyltransferase activity
FO456_RS07170	COG0826	peptidase U32
FO456_RS07175	COG0826	peptidase U32
FO456_RS07180	COG0572	uridine kinase
FO456_RS07185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FO456_RS07190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO456_RS07195	COG1984	allophanate hydrolase subunit 2
FO456_RS07200	COG0511	ligase activity, forming carbon-carbon bonds
FO456_RS07205	COG0439	Biotin carboxylase
FO456_RS07215	COG1914	H( )-stimulated, divalent metal cation uptake system
FO456_RS07220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FO456_RS07225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FO456_RS07230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FO456_RS07240	COG1534	Rna-binding protein
FO456_RS07245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FO456_RS07250	COG1713	HD superfamily hydrolase involved in NAD metabolism
FO456_RS07255	COG0799	negative regulation of ribosome biogenesis
FO456_RS07260	COG2226	methyltransferase
FO456_RS07270	COG2131	deaminase
FO456_RS07275	COG0658	competence protein
FO456_RS07275	COG2333	competence protein COMEC
FO456_RS07280	COG1466	dna polymerase III delta subunit
FO456_RS07285	COG0268	Binds directly to 16S ribosomal RNA
FO456_RS07290	COG0481	GTPase activity
FO456_RS07295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FO456_RS07305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FO456_RS07310	COG0443	Heat shock 70 kDa protein
FO456_RS07315	COG0484	heat shock protein binding
FO456_RS07320	COG2264	protein methyltransferase activity
FO456_RS07325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FO456_RS07330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO456_RS07340	COG1030	water channel activity
FO456_RS07345	COG4864	UPF0365 protein
FO456_RS07355	COG1702	phosphate starvation-inducible protein PhoH
FO456_RS07360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FO456_RS07365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FO456_RS07370	COG0295	cytidine deaminase activity
FO456_RS07375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FO456_RS07380	COG1381	Involved in DNA repair and RecF pathway recombination
FO456_RS07385	COG0423	glycine-tRNA ligase activity
FO456_RS07390	COG0517	IMP dehydrogenase activity
FO456_RS07395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FO456_RS07410	COG2384	SAM-dependent methyltransferase
FO456_RS07420	COG0513	Belongs to the DEAD box helicase family
FO456_RS07425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FO456_RS07430	COG1121	(ABC) transporter
FO456_RS07435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO456_RS07445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FO456_RS07450	COG0768	penicillin binding
FO456_RS07455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO456_RS07460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FO456_RS07465	COG0705	Rhomboid family
FO456_RS07465	COG0457	Tetratricopeptide repeat
FO456_RS07470	COG4483	Protein conserved in bacteria
FO456_RS07475	COG1940	carbohydrate kinase activity
FO456_RS07480	COG0011	TIGRFAM Protein of
FO456_RS07485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FO456_RS07490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FO456_RS07500	COG4537	Required for transformation and DNA binding
FO456_RS07525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FO456_RS07530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FO456_RS07535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO456_RS07540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FO456_RS07545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FO456_RS07550	COG0095	Lipoate-protein ligase
FO456_RS07565	COG0006	proline dipeptidase activity
FO456_RS07570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FO456_RS07575	COG0511	ligase activity, forming carbon-carbon bonds
FO456_RS07580	COG0439	Biotin carboxylase
FO456_RS07585	COG1302	Protein conserved in bacteria
FO456_RS07590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO456_RS07610	COG1438	arginine binding
FO456_RS07615	COG0497	DNA recombination
FO456_RS07620	COG0280	phosphate acetyltransferase
FO456_RS07625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO456_RS07630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FO456_RS07635	COG0022	dehydrogenase e1 component
FO456_RS07640	COG0508	dehydrogenase complex catalyzes the overall conversion of
FO456_RS07650	COG4129	membrane
FO456_RS07660	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO456_RS07670	COG1609	Transcriptional regulator
FO456_RS07675	COG0366	Alpha amylase catalytic
FO456_RS07685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FO456_RS07695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FO456_RS07700	COG0300	oxidoreductase activity
FO456_RS07705	COG0667	Aldo Keto reductase
FO456_RS07710	COG0494	nUDIX hydrolase
FO456_RS07715	COG0735	belongs to the Fur family
FO456_RS07720	COG4974	Belongs to the 'phage' integrase family
FO456_RS07730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FO456_RS07735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FO456_RS07740	COG1187	pseudouridine synthase activity
FO456_RS07745	COG0745	RESPONSE REGULATOR receiver
FO456_RS07760	COG1141	Ferredoxin
FO456_RS07770	COG0514	ATP-dependent DNA helicase (RecQ)
FO456_RS07775	COG1388	LysM domain
FO456_RS07780	COG0492	ferredoxin-NADP+ reductase activity
FO456_RS07800	COG0539	negative regulation of cytoplasmic translation
FO456_RS07810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FO456_RS07825	COG2226	methyltransferase
FO456_RS07830	COG0142	geranyltranstransferase activity
FO456_RS07840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FO456_RS07845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FO456_RS07850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FO456_RS07870	COG2738	Putative neutral zinc metallopeptidase
FO456_RS07875	COG1694	Mazg nucleotide pyrophosphohydrolase
FO456_RS07880	COG0438	transferase activity, transferring glycosyl groups
FO456_RS07885	COG0617	tRNA 3'-terminal CCA addition
FO456_RS07890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FO456_RS07890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FO456_RS07895	COG1199	ATP-dependent helicase activity
FO456_RS07895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FO456_RS07900	COG0017	Asparaginyl-tRNA synthetase
FO456_RS07905	COG3935	DnaD domain protein
FO456_RS07910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FO456_RS07920	COG4499	WXG100 protein secretion system (Wss), protein YukC
FO456_RS07920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FO456_RS07935	COG4474	Belongs to the UPF0398 family
FO456_RS07940	COG3599	regulation of cell shape
FO456_RS07950	COG0116	Belongs to the methyltransferase superfamily
FO456_RS07960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FO456_RS07965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FO456_RS07970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO456_RS07975	COG0512	Glutamine amidotransferase of anthranilate synthase
FO456_RS07980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO456_RS07985	COG0134	indole-3-glycerol-phosphate synthase activity
FO456_RS07990	COG0135	phosphoribosylanthranilate isomerase activity
FO456_RS08005	COG2348	transferase activity, transferring amino-acyl groups
FO456_RS08015	COG0561	phosphatase activity
FO456_RS08020	COG4607	ABC-type enterochelin transport system periplasmic component
FO456_RS08030	COG1164	Oligoendopeptidase f
FO456_RS08040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FO456_RS08045	COG0581	inorganic phosphate transmembrane transporter activity
FO456_RS08050	COG0573	inorganic phosphate transmembrane transporter activity
FO456_RS08055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FO456_RS08060	COG2996	Protein conserved in bacteria
FO456_RS08065	COG0488	(ABC) transporter
FO456_RS08070	COG0527	aspartate kinase activity
FO456_RS08075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FO456_RS08080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FO456_RS08085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FO456_RS08090	COG2171	N-acyltransferase activity
FO456_RS08095	COG1473	amidohydrolase
FO456_RS08120	COG1278	Cold shock
FO456_RS08130	COG1254	Belongs to the acylphosphatase family
FO456_RS08140	COG3853	Toxic anion resistance protein (TelA)
FO456_RS08145	COG1114	Component of the transport system for branched-chain amino acids
FO456_RS08150	COG4548	von Willebrand factor, type A
FO456_RS08155	COG0714	Associated with various cellular activities
FO456_RS08175	COG0567	Dehydrogenase, E1 component
FO456_RS08180	COG5002	protein histidine kinase activity
FO456_RS08185	COG0745	RESPONSE REGULATOR receiver
FO456_RS08190	COG0671	phosphoesterase, PA-phosphatase related
FO456_RS08195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO456_RS08205	COG0793	Belongs to the peptidase S41A family
FO456_RS08210	COG4479	Belongs to the UPF0346 family
FO456_RS08220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FO456_RS08250	COG1413	lyase activity
FO456_RS08260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FO456_RS08265	COG0328	RNA-DNA hybrid ribonuclease activity
FO456_RS08270	COG1363	Peptidase, m42
FO456_RS08285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS08295	COG3623	hexulose-6-phosphate isomerase
FO456_RS08315	COG0287	Prephenate dehydrogenase
FO456_RS08320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FO456_RS08325	COG1942	4-Oxalocrotonate Tautomerase
FO456_RS08355	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FO456_RS08355	COG0392	lysyltransferase activity
FO456_RS08360	COG0628	permease
FO456_RS08365	COG1115	amino acid carrier protein
FO456_RS08370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FO456_RS08375	COG0187	DNA topoisomerase II activity
FO456_RS08380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FO456_RS08385	COG4841	protein insertion into membrane
FO456_RS08395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FO456_RS08400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FO456_RS08405	COG1970	mechanosensitive ion channel activity
FO456_RS08420	COG4846	Membrane protein involved in cytochrome C biogenesis
FO456_RS08425	COG3763	UPF0154 protein
FO456_RS08430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FO456_RS08435	COG4224	UPF0291 protein
FO456_RS08445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO456_RS08455	COG2340	Cysteine-rich secretory protein family
FO456_RS08465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FO456_RS08480	COG0833	amino acid
FO456_RS08495	COG0083	homoserine kinase activity
FO456_RS08500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FO456_RS08505	COG0460	homoserine dehydrogenase
FO456_RS08510	COG0527	aspartate kinase activity
FO456_RS08525	COG1525	nuclease
FO456_RS08540	COG2197	response regulator
FO456_RS08545	COG2203	Gaf domain
FO456_RS08545	COG4585	Histidine kinase
FO456_RS08555	COG1131	(ABC) transporter
FO456_RS08560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FO456_RS08575	COG0789	Transcriptional regulator
FO456_RS08580	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FO456_RS08585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FO456_RS08595	COG1923	regulation of RNA biosynthetic process
FO456_RS08600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FO456_RS08610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FO456_RS08615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FO456_RS08620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FO456_RS08630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FO456_RS08635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FO456_RS08650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FO456_RS08665	COG4195	phage-related replication protein
FO456_RS08670	COG1013	pyruvate-flavodoxin oxidoreductase activity
FO456_RS08675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FO456_RS08675	COG0674	pyruvate-flavodoxin oxidoreductase activity
FO456_RS08680	COG1692	metallophosphoesterase
FO456_RS08690	COG1418	mRNA catabolic process
FO456_RS08695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FO456_RS08700	COG1058	Belongs to the CinA family
FO456_RS08700	COG1546	Belongs to the CinA family
FO456_RS08720	COG0300	oxidoreductase activity
FO456_RS08725	COG0612	Peptidase, M16
FO456_RS08730	COG0612	Peptidase, M16
FO456_RS08735	COG2188	Transcriptional regulator
FO456_RS08740	COG1674	ftsk spoiiie
FO456_RS08745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO456_RS08750	COG1185	polyribonucleotide nucleotidyltransferase activity
FO456_RS08760	COG0196	riboflavin kinase activity
FO456_RS08770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FO456_RS08775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FO456_RS08780	COG1358	cellular component organization or biogenesis
FO456_RS08785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FO456_RS08790	COG0195	Participates in both transcription termination and antitermination
FO456_RS08795	COG0779	Required for maturation of 30S ribosomal subunits
FO456_RS08800	COG2176	DNA-directed DNA polymerase activity
FO456_RS08805	COG0442	prolyl-tRNA aminoacylation
FO456_RS08820	COG4589	Belongs to the CDS family
FO456_RS08825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FO456_RS08830	COG0233	cytoplasmic translational termination
FO456_RS08835	COG0528	UMP kinase activity
FO456_RS08840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FO456_RS08845	COG0052	Belongs to the universal ribosomal protein uS2 family
FO456_RS08850	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FO456_RS08855	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FO456_RS08860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FO456_RS08865	COG4974	Belongs to the 'phage' integrase family
FO456_RS08870	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FO456_RS08875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FO456_RS08880	COG0758	DNA mediated transformation
FO456_RS08885	COG2348	transferase activity, transferring amino-acyl groups
FO456_RS08895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FO456_RS08900	COG0045	succinate-CoA ligase (ADP-forming) activity
FO456_RS08905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO456_RS08915	COG4485	Bacterial membrane protein, YfhO
FO456_RS08925	COG0335	large ribosomal subunit rRNA binding
FO456_RS08930	COG0336	Belongs to the RNA methyltransferase TrmD family
FO456_RS08935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FO456_RS08940	COG0228	four-way junction DNA binding
FO456_RS08955	COG0183	Belongs to the thiolase family
FO456_RS08960	COG0318	PFAM AMP-dependent synthetase and ligase
FO456_RS08965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FO456_RS08970	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FO456_RS08975	COG0552	protein localization to endoplasmic reticulum
FO456_RS08980	COG1196	nuclear chromosome segregation
FO456_RS08985	COG0571	ribonuclease III activity
FO456_RS08990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO456_RS09005	COG0416	fatty acid biosynthetic process
FO456_RS09010	COG1349	DNA-binding transcription factor activity
FO456_RS09015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FO456_RS09020	COG1461	Dihydroxyacetone kinase
FO456_RS09025	COG1302	Protein conserved in bacteria
FO456_RS09030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FO456_RS09040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FO456_RS09055	COG0631	protein serine/threonine phosphatase activity
FO456_RS09065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FO456_RS09065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FO456_RS09070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FO456_RS09080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FO456_RS09085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FO456_RS09090	COG1758	RNA polymerase activity
FO456_RS09095	COG0194	GDP metabolic process
FO456_RS09115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FO456_RS09120	COG0284	orotidine-5'-phosphate decarboxylase activity
FO456_RS09130	COG0505	Belongs to the CarA family
FO456_RS09140	COG0540	Belongs to the ATCase OTCase family
FO456_RS09145	COG2233	PERMEase
FO456_RS09150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FO456_RS09155	COG0564	pseudouridine synthase activity
FO456_RS09160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FO456_RS09170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FO456_RS09175	COG3599	regulation of cell shape
FO456_RS09180	COG2302	S4 RNA-binding domain
FO456_RS09185	COG0762	integral membrane protein
FO456_RS09190	COG1799	cell septum assembly
FO456_RS09195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FO456_RS09200	COG1496	oxidoreductase activity
FO456_RS09205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FO456_RS09210	COG0849	cell division
FO456_RS09215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FO456_RS09220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FO456_RS09225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO456_RS09230	COG0768	penicillin binding
FO456_RS09235	COG4839	cell division protein FtsL
FO456_RS09240	COG0275	rRNA processing
FO456_RS09250	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FO456_RS09255	COG0454	-acetyltransferase
FO456_RS09265	COG1011	Hydrolase
FO456_RS09275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FO456_RS09280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FO456_RS09285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FO456_RS09290	COG1053	succinate dehydrogenase
FO456_RS09295	COG2009	succinate dehydrogenase
FO456_RS09300	COG0322	excinuclease ABC activity
FO456_RS09305	COG3118	belongs to the thioredoxin family
FO456_RS09310	COG1193	negative regulation of DNA recombination
FO456_RS09315	COG1796	DNA polymerase
FO456_RS09315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FO456_RS09325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FO456_RS09330	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FO456_RS09335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FO456_RS09335	COG0072	phenylalanine-tRNA ligase activity
FO456_RS09340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FO456_RS09345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO456_RS09350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FO456_RS09365	COG1323	Belongs to the UPF0348 family
FO456_RS09370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FO456_RS09375	COG0742	ribosomal rna small subunit methyltransferase
FO456_RS09390	COG0584	glycerophosphoryl diester phosphodiesterase
FO456_RS09395	COG3679	Belongs to the UPF0342 family
FO456_RS09410	COG0109	protoheme IX farnesyltransferase activity
FO456_RS09415	COG1612	heme a metabolic process
FO456_RS09425	COG0772	Belongs to the SEDS family
FO456_RS09430	COG4838	Belongs to the UPF0358 family
FO456_RS09435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FO456_RS09445	COG1217	gtp-binding protein TYPA
FO456_RS09455	COG0483	inositol monophosphate 1-phosphatase activity
FO456_RS09460	COG4493	Belongs to the UPF0637 family
FO456_RS09480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FO456_RS09485	COG1177	transmembrane transport
FO456_RS09505	COG4476	Belongs to the UPF0223 family
FO456_RS09520	COG0022	dehydrogenase e1 component
FO456_RS09535	COG0242	peptide deformylase activity
FO456_RS09540	COG5503	Protein of unknown function (DUF1447)
FO456_RS09545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FO456_RS09555	COG0569	domain protein
FO456_RS09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FO456_RS09585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FO456_RS09600	COG4172	Belongs to the ABC transporter superfamily
FO456_RS09605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FO456_RS09610	COG0151	Belongs to the GarS family
FO456_RS09615	COG0138	bifunctional purine biosynthesis protein purh
FO456_RS09625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FO456_RS09635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO456_RS09640	COG0047	phosphoribosylformylglycinamidine synthase activity
FO456_RS09645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FO456_RS09650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FO456_RS09655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FO456_RS09660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FO456_RS09665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FO456_RS09675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FO456_RS09675	COG1017	nitric oxide dioxygenase activity
FO456_RS09685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FO456_RS09695	COG1845	cytochrome c oxidase, subunit III
FO456_RS09700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FO456_RS09710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FO456_RS09715	COG1316	TRANSCRIPTIONal
FO456_RS09745	COG3594	Acyltransferase
FO456_RS09750	COG0436	Aminotransferase
FO456_RS09755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FO456_RS09760	COG0596	Alpha beta hydrolase
FO456_RS09765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FO456_RS09770	COG1169	isochorismate synthase
FO456_RS09775	COG1575	Belongs to the MenA family. Type 1 subfamily
FO456_RS09830	COG4873	Protein conserved in bacteria
FO456_RS09840	COG0737	Belongs to the 5'-nucleotidase family
FO456_RS09845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FO456_RS09850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FO456_RS09855	COG0861	Integral membrane protein TerC family
FO456_RS09870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FO456_RS09875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FO456_RS09880	COG2814	Major facilitator Superfamily
FO456_RS09885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FO456_RS09890	COG0789	Transcriptional regulator
FO456_RS09895	COG4221	oxidoreductase activity
FO456_RS09905	COG0628	permease
FO456_RS09915	COG0475	glutathione-regulated potassium exporter activity
FO456_RS09915	COG0569	domain protein
FO456_RS09920	COG2239	Acts as a magnesium transporter
FO456_RS09925	COG0564	pseudouridine synthase activity
FO456_RS09935	COG2357	RelA SpoT domain protein
FO456_RS09950	COG2346	COG2346, Truncated hemoglobins
FO456_RS09955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FO456_RS09960	COG1164	Oligoendopeptidase f
FO456_RS09975	COG1393	Belongs to the ArsC family
FO456_RS09980	COG0180	Tryptophanyl-tRNA synthetase
FO456_RS09985	COG2226	methyltransferase
FO456_RS09990	COG4166	transmembrane transport
FO456_RS09995	COG4608	Belongs to the ABC transporter superfamily
FO456_RS10000	COG0444	Belongs to the ABC transporter superfamily
FO456_RS10005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FO456_RS10010	COG0601	transmembrane transport
FO456_RS10025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FO456_RS10035	COG0542	response to heat
FO456_RS10045	COG0561	phosphatase activity
FO456_RS10050	COG0446	pyridine nucleotide-disulphide oxidoreductase
FO456_RS10065	COG1074	ATP-dependent DNA helicase activity
FO456_RS10085	COG0398	Pfam SNARE associated Golgi protein
FO456_RS10090	COG0166	Belongs to the GPI family
FO456_RS10095	COG0137	argininosuccinate synthase activity
FO456_RS10125	COG1902	pentaerythritol trinitrate reductase activity
FO456_RS10130	COG1098	S1 RNA binding domain
FO456_RS10135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FO456_RS10145	COG2111	Na H antiporter
FO456_RS10145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO456_RS10150	COG2111	Na H antiporter
FO456_RS10155	COG1006	Multisubunit Na H antiporter MnhC subunit
FO456_RS10160	COG0651	ATP synthesis coupled electron transport
FO456_RS10165	COG1863	multisubunit Na H antiporter MnhE subunit
FO456_RS10170	COG2212	antiporter activity
FO456_RS10175	COG1320	monovalent cation:proton antiporter activity
FO456_RS10185	COG2050	protein possibly involved in aromatic compounds catabolism
FO456_RS10190	COG2056	Na+-H+ antiporter family
FO456_RS10195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FO456_RS10200	COG1252	NADH dehydrogenase
FO456_RS10210	COG1132	(ABC) transporter
FO456_RS10220	COG1129	ABC transporter
FO456_RS10250	COG2226	methyltransferase
FO456_RS10250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO456_RS10250	COG3433	isochorismatase activity
FO456_RS10255	COG1021	2,3-dihydroxybenzoate-AMP ligase
FO456_RS10270	COG0316	Belongs to the HesB IscA family
FO456_RS10275	COG4844	belongs to the
FO456_RS10280	COG1252	NADH dehydrogenase
FO456_RS10285	COG4837	Protein of unknown function (DUF1462)
FO456_RS10290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FO456_RS10295	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FO456_RS10300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FO456_RS10305	COG1696	Membrane protein involved in D-alanine export
FO456_RS10310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FO456_RS10320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FO456_RS10325	COG0647	UMP catabolic process
FO456_RS10330	COG2445	Protein of unknown function DUF86
FO456_RS10340	COG4470	Protein conserved in bacteria
FO456_RS10345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FO456_RS10350	COG0737	Belongs to the 5'-nucleotidase family
FO456_RS10355	COG0730	response to heat
FO456_RS10360	COG1801	Protein of unknown function DUF72
FO456_RS10365	COG2070	2-Nitropropane dioxygenase
FO456_RS10370	COG1253	flavin adenine dinucleotide binding
FO456_RS10490	COG1388	LysM domain
FO456_RS10490	COG3942	CHAP domain
FO456_RS10515	COG0719	Fe-S assembly protein
FO456_RS10520	COG0822	iron-sulfur transferase activity
FO456_RS10530	COG0719	Fe-S assembly protein
FO456_RS10535	COG0396	ATPase activity
FO456_RS10555	COG1464	Belongs to the NlpA lipoprotein family
FO456_RS10560	COG2011	ABC-type metal ion transport system permease component
FO456_RS10565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FO456_RS10575	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FO456_RS10580	COG0509	glycine decarboxylation via glycine cleavage system
FO456_RS10585	COG1393	Belongs to the ArsC family
FO456_RS10590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FO456_RS10600	COG0710	3-dehydroquinate dehydratase activity
FO456_RS10605	COG1764	response to oxidative stress
FO456_RS10615	COG0588	phosphoglycerate mutase activity
FO456_RS10645	COG4195	phage-related replication protein
FO456_RS10660	COG2259	Doxx family
FO456_RS10665	COG0346	lactoylglutathione lyase activity
FO456_RS10675	COG1611	Belongs to the LOG family
FO456_RS10780	COG0557	exoribonuclease II activity
FO456_RS10785	COG1647	Serine aminopeptidase, S33
FO456_RS10790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO456_RS10800	COG0148	phosphopyruvate hydratase activity
FO456_RS10805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FO456_RS10810	COG0149	triose-phosphate isomerase activity
FO456_RS10815	COG0126	phosphoglycerate kinase activity
FO456_RS10835	COG1090	epimerase
FO456_RS10840	COG0740	serine-type endopeptidase activity
FO456_RS10845	COG1481	regulation of sporulation
FO456_RS10850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FO456_RS10855	COG1660	Displays ATPase and GTPase activities
FO456_RS10860	COG0492	ferredoxin-NADP+ reductase activity
FO456_RS10875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FO456_RS10880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FO456_RS10885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FO456_RS10905	COG1388	LysM domain
FO456_RS10905	COG3942	CHAP domain
FO456_RS10915	COG0653	protein targeting
FO456_RS10925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FO456_RS10930	COG1040	competence protein
FO456_RS10945	COG1739	Uncharacterized protein family UPF0029
FO456_RS10950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FO456_RS10955	COG2199	diguanylate cyclase activity
FO456_RS10970	COG2195	Cleaves the N-terminal amino acid of tripeptides
FO456_RS10975	COG1929	Belongs to the glycerate kinase type-1 family
FO456_RS10995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FO456_RS11005	COG4607	ABC-type enterochelin transport system periplasmic component
FO456_RS11010	COG4604	ABC transporter, ATP-binding protein
FO456_RS11015	COG4605	iron ion homeostasis
FO456_RS11020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS11025	COG4607	ABC-type enterochelin transport system periplasmic component
FO456_RS11030	COG4604	ABC transporter, ATP-binding protein
FO456_RS11035	COG4605	iron ion homeostasis
FO456_RS11040	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS11045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO456_RS11050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FO456_RS11055	COG1780	Probably involved in ribonucleotide reductase function
FO456_RS11065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FO456_RS11070	COG3104	oligopeptide transport
FO456_RS11075	COG1597	lipid kinase activity
FO456_RS11085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FO456_RS11090	COG3104	oligopeptide transport
FO456_RS11095	COG1174	glycine betaine transport
FO456_RS11105	COG0514	ATP-dependent DNA helicase (RecQ)
FO456_RS11110	COG0488	(ABC) transporter
FO456_RS11120	COG1368	sulfuric ester hydrolase activity
FO456_RS11130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FO456_RS11140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FO456_RS11140	COG0512	Glutamine amidotransferase of anthranilate synthase
FO456_RS11145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FO456_RS11145	COG0512	Glutamine amidotransferase of anthranilate synthase
FO456_RS11155	COG0720	synthase
FO456_RS11170	COG0463	Glycosyl transferase, family 2
FO456_RS11175	COG0656	L-ascorbic acid biosynthetic process
FO456_RS11180	COG1253	flavin adenine dinucleotide binding
FO456_RS11185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO456_RS11185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FO456_RS11185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FO456_RS11190	COG1105	Belongs to the carbohydrate kinase PfkB family
FO456_RS11195	COG1349	DNA-binding transcription factor activity
FO456_RS11200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FO456_RS11230	COG0415	Belongs to the DNA photolyase family
FO456_RS11235	COG0471	metal ion transport
FO456_RS11240	COG0039	L-malate dehydrogenase activity
FO456_RS11255	COG0523	cobalamin synthesis protein
FO456_RS11265	COG1968	undecaprenyl-diphosphatase activity
FO456_RS11275	COG1671	Belongs to the UPF0178 family
FO456_RS11280	COG1611	Belongs to the LOG family
FO456_RS11305	COG2839	Protein conserved in bacteria
FO456_RS11310	COG2814	Major facilitator Superfamily
FO456_RS11315	COG0583	DNA-binding transcription factor activity
FO456_RS11330	COG0217	transcriptional regulatory protein
FO456_RS11350	COG1388	LysM domain
FO456_RS11350	COG3942	CHAP domain
FO456_RS11355	COG0306	phosphate transporter
FO456_RS11360	COG1392	Phosphate transport regulator
FO456_RS11365	COG0577	efflux transmembrane transporter activity
FO456_RS11370	COG1136	(ABC) transporter
FO456_RS11375	COG2205	protein histidine kinase activity
FO456_RS11380	COG0745	RESPONSE REGULATOR receiver
FO456_RS11385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FO456_RS11395	COG0657	acetylesterase activity
FO456_RS11400	COG3949	Membrane
FO456_RS11410	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FO456_RS11415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS11420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS11425	COG1120	ATPase activity
FO456_RS11430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FO456_RS11440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO456_RS11450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS11450	COG0463	Glycosyl transferase, family 2
FO456_RS11455	COG0438	transferase activity, transferring glycosyl groups
FO456_RS11460	COG1132	(ABC) transporter
FO456_RS11465	COG1686	Belongs to the peptidase S11 family
FO456_RS11470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FO456_RS11475	COG1216	Glycosyl transferase, family 2
FO456_RS11475	COG1442	glycosyl transferase family 8
FO456_RS11480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS11485	COG1682	transport, permease protein
FO456_RS11490	COG1134	teichoic acid transport
FO456_RS11505	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FO456_RS11515	COG1321	iron dependent repressor
FO456_RS11520	COG1121	(ABC) transporter
FO456_RS11525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FO456_RS11530	COG0803	Belongs to the bacterial solute-binding protein 9 family
FO456_RS11540	COG1320	monovalent cation:proton antiporter activity
FO456_RS11545	COG2212	antiporter activity
FO456_RS11550	COG1863	multisubunit Na H antiporter MnhE subunit
FO456_RS11555	COG0651	ATP synthesis coupled electron transport
FO456_RS11560	COG1006	Multisubunit Na H antiporter MnhC subunit
FO456_RS11565	COG2111	Na H antiporter
FO456_RS11570	COG2111	Na H antiporter
FO456_RS11570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FO456_RS11575	COG4974	Belongs to the 'phage' integrase family
FO456_RS11605	COG0596	Alpha beta hydrolase
FO456_RS11630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FO456_RS11635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FO456_RS11655	COG0018	arginyl-trna synthetase
FO456_RS11675	COG1064	alcohol dehydrogenase
FO456_RS11685	COG1078	dGTPase activity
FO456_RS11695	COG0655	NAD(P)H dehydrogenase (quinone) activity
FO456_RS11700	COG0667	Aldo Keto reductase
FO456_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO456_RS11725	COG1388	LysM domain
FO456_RS11725	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO456_RS11965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO456_RS11980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO456_RS11995	COG0860	N-Acetylmuramoyl-L-alanine amidase
FO456_RS11995	COG1388	LysM domain
FO456_RS12170	COG1484	DNA-dependent DNA replication
FO456_RS12240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FO456_RS12255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FO456_RS12260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FO456_RS12265	COG4844	belongs to the
FO456_RS12285	COG0095	Lipoate-protein ligase
FO456_RS12295	COG3253	May function as heme-dependent peroxidase
FO456_RS12325	COG0531	amino acid
FO456_RS12330	COG2363	Small membrane protein
FO456_RS12340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FO456_RS12375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FO456_RS12380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FO456_RS12390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FO456_RS12400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FO456_RS12425	COG0561	phosphatase activity
FO456_RS12435	COG1428	Deoxynucleoside kinase
FO456_RS12440	COG1428	Deoxynucleoside kinase
FO456_RS12460	COG0531	amino acid
FO456_RS12465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FO456_RS12475	COG1279	arginine transmembrane transporter activity
FO456_RS12500	COG1473	amidohydrolase
FO456_RS12505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FO456_RS12520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FO456_RS12530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FO456_RS12535	COG0085	RNA polymerase activity
FO456_RS12540	COG2813	Specifically methylates the guanine in position
FO456_RS12550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FO456_RS12560	COG0081	regulation of translation
FO456_RS12570	COG0250	Participates in transcription elongation, termination and antitermination
FO456_RS12575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FO456_RS12580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FO456_RS12590	COG3688	RNA-binding protein containing a PIN domain
FO456_RS12595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FO456_RS12600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FO456_RS12605	COG0215	cysteine-tRNA ligase activity
FO456_RS12610	COG1045	serine acetyltransferase
FO456_RS12615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FO456_RS12620	COG4956	integral membrane protein (PIN domain superfamily)
FO456_RS12625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FO456_RS12630	COG0542	response to heat
FO456_RS12635	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FO456_RS12640	COG3880	PFAM UvrB UvrC protein
FO456_RS12645	COG4463	regulation of RNA biosynthetic process
FO456_RS12650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FO456_RS12655	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS