locus-tag	class	description
B5P37_RS00015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5P37_RS00050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5P37_RS00055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5P37_RS00060	COG0011	TIGRFAM Protein of
B5P37_RS00065	COG1940	carbohydrate kinase activity
B5P37_RS00070	COG4483	Protein conserved in bacteria
B5P37_RS00075	COG0705	Rhomboid family
B5P37_RS00080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5P37_RS00085	COG0704	Plays a role in the regulation of phosphate uptake
B5P37_RS00090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5P37_RS00095	COG0581	inorganic phosphate transmembrane transporter activity
B5P37_RS00100	COG0573	inorganic phosphate transmembrane transporter activity
B5P37_RS00105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5P37_RS00110	COG0768	penicillin binding
B5P37_RS00115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B5P37_RS00120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5P37_RS00125	COG0735	belongs to the Fur family
B5P37_RS00130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5P37_RS00135	COG1121	(ABC) transporter
B5P37_RS00140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B5P37_RS00145	COG0513	Belongs to the DEAD box helicase family
B5P37_RS00150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5P37_RS00155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5P37_RS00160	COG2384	SAM-dependent methyltransferase
B5P37_RS00165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5P37_RS00170	COG0358	DNA primase activity
B5P37_RS00175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B5P37_RS00180	COG0517	IMP dehydrogenase activity
B5P37_RS00185	COG0423	glycine-tRNA ligase activity
B5P37_RS00190	COG1381	Involved in DNA repair and RecF pathway recombination
B5P37_RS00195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5P37_RS00200	COG0295	cytidine deaminase activity
B5P37_RS00205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5P37_RS00210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5P37_RS00215	COG1702	phosphate starvation-inducible protein PhoH
B5P37_RS00225	COG4864	UPF0365 protein
B5P37_RS00240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5P37_RS00245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5P37_RS00250	COG2264	protein methyltransferase activity
B5P37_RS00255	COG0484	heat shock protein binding
B5P37_RS00260	COG0443	Heat shock 70 kDa protein
B5P37_RS00265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5P37_RS00270	COG1420	regulation of RNA biosynthetic process
B5P37_RS00275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5P37_RS00285	COG0268	Binds directly to 16S ribosomal RNA
B5P37_RS00290	COG1466	dna polymerase III delta subunit
B5P37_RS00300	COG2131	deaminase
B5P37_RS00305	COG1555	photosystem II stabilization
B5P37_RS00305	COG1596	polysaccharide export
B5P37_RS00310	COG2226	methyltransferase
B5P37_RS00315	COG0799	negative regulation of ribosome biogenesis
B5P37_RS00320	COG1713	HD superfamily hydrolase involved in NAD metabolism
B5P37_RS00330	COG1534	Rna-binding protein
B5P37_RS00335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5P37_RS00340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B5P37_RS00345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B5P37_RS00350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5P37_RS00355	COG1914	H( )-stimulated, divalent metal cation uptake system
B5P37_RS00360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5P37_RS00365	COG0439	Biotin carboxylase
B5P37_RS00375	COG1984	allophanate hydrolase subunit 2
B5P37_RS00380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B5P37_RS00390	COG0572	uridine kinase
B5P37_RS00395	COG0826	peptidase U32
B5P37_RS00400	COG0826	peptidase U32
B5P37_RS00405	COG4122	O-methyltransferase activity
B5P37_RS00410	COG3906	Belongs to the UPF0473 family
B5P37_RS00420	COG4472	Bacterial protein of unknown function (DUF965)
B5P37_RS00425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5P37_RS00430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5P37_RS00440	COG0482	sulfurtransferase activity
B5P37_RS00445	COG1104	cysteine desulfurase activity
B5P37_RS00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5P37_RS00465	COG1959	2 iron, 2 sulfur cluster binding
B5P37_RS00470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5P37_RS00475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5P37_RS00485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5P37_RS00495	COG3344	reverse transcriptase
B5P37_RS00525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5P37_RS00525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B5P37_RS00530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5P37_RS00530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5P37_RS00535	COG1862	Preprotein translocase
B5P37_RS00550	COG2255	four-way junction helicase activity
B5P37_RS00555	COG0632	four-way junction helicase activity
B5P37_RS00565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5P37_RS00575	COG2868	ribosomal protein
B5P37_RS00590	COG1792	Involved in formation and maintenance of cell shape
B5P37_RS00600	COG2003	Belongs to the UPF0758 family
B5P37_RS00610	COG0285	dihydrofolate synthase activity
B5P37_RS00615	COG0525	valine-tRNA ligase activity
B5P37_RS00620	COG2818	Glycosylase
B5P37_RS00630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5P37_RS00645	COG0181	hydroxymethylbilane synthase activity
B5P37_RS00660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5P37_RS00665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5P37_RS00670	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5P37_RS00680	COG4112	unkown
B5P37_RS00685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5P37_RS00690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5P37_RS00705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5P37_RS00710	COG1484	DNA-dependent DNA replication
B5P37_RS00715	COG3611	Membrane attachment protein
B5P37_RS00725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5P37_RS00730	COG0237	dephospho-CoA kinase activity
B5P37_RS00735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5P37_RS00740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5P37_RS00740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5P37_RS00745	COG5002	protein histidine kinase activity
B5P37_RS00750	COG0745	RESPONSE REGULATOR receiver
B5P37_RS00755	COG0538	isocitrate dehydrogenase activity
B5P37_RS00760	COG0372	Belongs to the citrate synthase family
B5P37_RS00765	COG0469	pyruvate kinase activity
B5P37_RS00770	COG0205	6-phosphofructokinase activity
B5P37_RS00775	COG0825	malonyl-CoA metabolic process
B5P37_RS00785	COG0281	malic enzyme
B5P37_RS00795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B5P37_RS00800	COG4109	DRTGG domain
B5P37_RS00805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B5P37_RS00810	COG0006	proline dipeptidase activity
B5P37_RS00825	COG0686	Belongs to the AlaDH PNT family
B5P37_RS00830	COG0589	response to stress
B5P37_RS00835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5P37_RS00840	COG0827	DNA restriction-modification system
B5P37_RS00845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B5P37_RS00850	COG1714	RDD family
B5P37_RS00855	COG0616	signal peptide processing
B5P37_RS00860	COG0730	response to heat
B5P37_RS00865	COG0301	tRNA thio-modification
B5P37_RS00870	COG1104	cysteine desulfurase activity
B5P37_RS00875	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B5P37_RS00880	COG1956	GAF domain-containing protein
B5P37_RS00885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5P37_RS00900	COG0584	glycerophosphoryl diester phosphodiesterase
B5P37_RS00905	COG1764	response to oxidative stress
B5P37_RS00910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5P37_RS00915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5P37_RS00925	COG0204	Acyl-transferase
B5P37_RS00930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5P37_RS00940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5P37_RS00950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5P37_RS00955	COG0454	-acetyltransferase
B5P37_RS00960	COG0123	including yeast histone deacetylase and acetoin utilization protein
B5P37_RS00965	COG1609	Transcriptional regulator
B5P37_RS00970	COG1605	Chorismate mutase
B5P37_RS00970	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B5P37_RS00980	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B5P37_RS00985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5P37_RS00990	COG1674	ftsk spoiiie
B5P37_RS00995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5P37_RS01005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5P37_RS01020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5P37_RS01025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5P37_RS01030	COG0510	thiamine kinase activity
B5P37_RS01035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5P37_RS01040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5P37_RS01050	COG1187	pseudouridine synthase activity
B5P37_RS01055	COG2244	polysaccharide biosynthetic process
B5P37_RS01060	COG2081	HI0933 family
B5P37_RS01065	COG3344	reverse transcriptase
B5P37_RS01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5P37_RS01080	COG2814	Major facilitator Superfamily
B5P37_RS01085	COG1242	4 iron, 4 sulfur cluster binding
B5P37_RS01090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B5P37_RS01100	COG0039	L-malate dehydrogenase activity
B5P37_RS01105	COG2267	carboxylic ester hydrolase activity
B5P37_RS01115	COG0506	proline dehydrogenase activity
B5P37_RS01120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5P37_RS01125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5P37_RS01125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5P37_RS01135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5P37_RS01135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5P37_RS01145	COG5632	N-Acetylmuramoyl-L-alanine amidase
B5P37_RS01145	COG3266	domain, Protein
B5P37_RS01145	COG4193	domain, Protein
B5P37_RS01170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5P37_RS01180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5P37_RS01185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5P37_RS01190	COG0656	L-ascorbic acid biosynthetic process
B5P37_RS01200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5P37_RS01210	COG1506	peptidase
B5P37_RS01215	COG0494	nUDIX hydrolase
B5P37_RS01220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5P37_RS01245	COG3623	hexulose-6-phosphate isomerase
B5P37_RS01265	COG3037	sugar-specific permease SgaT UlaA
B5P37_RS01375	COG3545	Serine hydrolase
B5P37_RS01380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B5P37_RS01390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5P37_RS01400	COG4473	ABC transporter
B5P37_RS01405	COG1131	(ABC) transporter
B5P37_RS01410	COG0537	adenosine 5'-monophosphoramidase activity
B5P37_RS01420	COG1846	Transcriptional regulator
B5P37_RS01430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5P37_RS01435	COG3481	metal-dependent phosphohydrolase, HD sub domain
B5P37_RS01445	COG0420	3'-5' exonuclease activity
B5P37_RS01450	COG3679	Belongs to the UPF0342 family
B5P37_RS01470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B5P37_RS01475	COG2197	response regulator
B5P37_RS01480	COG2203	Gaf domain
B5P37_RS01480	COG4585	Histidine kinase
B5P37_RS01485	COG0564	pseudouridine synthase activity
B5P37_RS01490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5P37_RS01500	COG0114	fumarate hydratase activity
B5P37_RS01510	COG0363	glucosamine-6-phosphate deaminase activity
B5P37_RS01520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5P37_RS01525	COG1126	abc transporter atp-binding protein
B5P37_RS01530	COG0765	amino acid transport
B5P37_RS01725	COG0735	belongs to the Fur family
B5P37_RS01730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5P37_RS01735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5P37_RS01740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5P37_RS01745	COG4129	membrane
B5P37_RS01750	COG0069	glutamate synthase activity
B5P37_RS01760	COG3557	Belongs to the UPF0374 family
B5P37_RS01765	COG1194	a g-specific adenine glycosylase
B5P37_RS01770	COG1988	membrane-bound metal-dependent
B5P37_RS01780	COG1134	teichoic acid transport
B5P37_RS01780	COG1388	LysM domain
B5P37_RS01790	COG2137	regulation of response to DNA damage stimulus
B5P37_RS01795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5P37_RS01800	COG0028	Belongs to the TPP enzyme family
B5P37_RS01805	COG0693	protein deglycase activity
B5P37_RS01810	COG0535	radical SAM domain protein
B5P37_RS01815	COG1607	acyl-coa hydrolase
B5P37_RS01820	COG2309	aminopeptidase activity
B5P37_RS01825	COG4840	Belongs to the UPF0435 family
B5P37_RS01830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5P37_RS01840	COG1295	ribonuclease BN
B5P37_RS01845	COG0288	reversible hydration of carbon dioxide
B5P37_RS01875	COG4129	membrane
B5P37_RS01880	COG4409	exo-alpha-(2->6)-sialidase activity
B5P37_RS01885	COG2211	Major facilitator Superfamily
B5P37_RS01890	COG0673	inositol 2-dehydrogenase activity
B5P37_RS01905	COG1528	Iron-storage protein
B5P37_RS01915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5P37_RS01925	COG0488	(ABC) transporter
B5P37_RS01950	COG1597	lipid kinase activity
B5P37_RS01955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5P37_RS01965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5P37_RS01970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5P37_RS01975	COG4851	CamS sex pheromone cAM373 precursor
B5P37_RS01980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5P37_RS01985	COG0210	DNA helicase
B5P37_RS01990	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B5P37_RS01995	COG4496	protein, YerC YecD
B5P37_RS02000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5P37_RS02010	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B5P37_RS02015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B5P37_RS02020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B5P37_RS02030	COG0077	Prephenate dehydratase
B5P37_RS02030	COG1605	Chorismate mutase
B5P37_RS02040	COG1335	isochorismatase
B5P37_RS02045	COG1227	inorganic diphosphatase activity
B5P37_RS02050	COG2388	GCN5-related N-acetyl-transferase
B5P37_RS02055	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS02060	COG2706	6-phosphogluconolactonase activity
B5P37_RS02095	COG1131	(ABC) transporter
B5P37_RS02105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5P37_RS02110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5P37_RS02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5P37_RS02125	COG1131	(ABC) transporter
B5P37_RS02130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5P37_RS02180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5P37_RS02200	COG4512	PFAM Accessory gene regulator B
B5P37_RS02220	COG1621	beta-fructofuranosidase activity
B5P37_RS02230	COG0488	(ABC) transporter
B5P37_RS02235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5P37_RS02240	COG0456	acetyltransferase
B5P37_RS02245	COG1214	PFAM Peptidase M22, glycoprotease
B5P37_RS02250	COG0802	atpase or kinase
B5P37_RS02255	COG0129	dihydroxy-acid dehydratase activity
B5P37_RS02260	COG0028	Belongs to the TPP enzyme family
B5P37_RS02270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5P37_RS02275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5P37_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
B5P37_RS02285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5P37_RS02295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5P37_RS02330	COG2183	response to ionizing radiation
B5P37_RS02340	COG1191	sigma factor activity
B5P37_RS02355	COG2208	phosphoserine phosphatase activity
B5P37_RS02360	COG2337	Toxic component of a toxin-antitoxin (TA) module
B5P37_RS02375	COG0736	holo-[acyl-carrier-protein] synthase activity
B5P37_RS02380	COG3402	PFAM membrane-flanked domain
B5P37_RS02400	COG0513	Belongs to the DEAD box helicase family
B5P37_RS02405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5P37_RS02410	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5P37_RS02415	COG0772	Belongs to the SEDS family
B5P37_RS02435	COG2217	Heavy metal translocating P-type atpase
B5P37_RS02440	COG2608	mercury ion transmembrane transporter activity
B5P37_RS02450	COG1937	Protein conserved in bacteria
B5P37_RS02460	COG1418	mRNA catabolic process
B5P37_RS02465	COG0706	membrane insertase activity
B5P37_RS02470	COG0352	thiamine-phosphate diphosphorylase activity
B5P37_RS02475	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B5P37_RS02485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B5P37_RS02500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5P37_RS02510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5P37_RS02530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5P37_RS02540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5P37_RS02550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5P37_RS02555	COG0356	it plays a direct role in the translocation of protons across the membrane
B5P37_RS02565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B5P37_RS02570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5P37_RS02580	COG4475	Protein of unknown function (DUF436)
B5P37_RS02585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5P37_RS02590	COG0009	L-threonylcarbamoyladenylate synthase
B5P37_RS02595	COG2890	protein-(glutamine-N5) methyltransferase activity
B5P37_RS02600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5P37_RS02610	COG0254	rRNA binding
B5P37_RS02615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B5P37_RS02625	COG1733	regulation of RNA biosynthetic process
B5P37_RS02630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5P37_RS02635	COG0191	fructose-bisphosphate aldolase activity
B5P37_RS02640	COG4821	SIS domain
B5P37_RS02645	COG2271	Major facilitator Superfamily
B5P37_RS02660	COG0456	acetyltransferase
B5P37_RS02670	COG5146	pantothenate kinase activity
B5P37_RS02695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B5P37_RS02700	COG0813	purine-nucleoside phosphorylase activity
B5P37_RS02715	COG1482	cell wall glycoprotein biosynthetic process
B5P37_RS02720	COG2186	Transcriptional regulator
B5P37_RS02745	COG3711	transcriptional antiterminator
B5P37_RS02755	COG0246	Mannitol dehydrogenase
B5P37_RS02760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5P37_RS02825	COG0489	protein tyrosine kinase activity
B5P37_RS02830	COG2814	Major facilitator Superfamily
B5P37_RS02845	COG1272	protein, Hemolysin III
B5P37_RS02850	COG4284	Utp--glucose-1-phosphate uridylyltransferase
B5P37_RS02855	COG1988	membrane-bound metal-dependent
B5P37_RS02865	COG3314	Sporulation integral membrane protein YlbJ
B5P37_RS02870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS02875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS02880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B5P37_RS02885	COG3457	Alanine racemase
B5P37_RS02890	COG4264	IucA IucC family
B5P37_RS02895	COG2814	Major facilitator Superfamily
B5P37_RS02900	COG4264	IucA IucC family
B5P37_RS02905	COG2814	Major facilitator Superfamily
B5P37_RS02910	COG1302	Protein conserved in bacteria
B5P37_RS02940	COG1518	maintenance of DNA repeat elements
B5P37_RS02955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B5P37_RS02955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B5P37_RS02965	COG3684	Belongs to the aldolase LacD family
B5P37_RS03050	COG2801	Transposase and inactivated derivatives
B5P37_RS03060	COG5290	Psort location Cytoplasmic, score
B5P37_RS03160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5P37_RS03165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5P37_RS03170	COG0101	tRNA pseudouridine synthase activity
B5P37_RS03180	COG1122	ATPase activity
B5P37_RS03185	COG1122	ATPase activity
B5P37_RS03190	COG0203	ribosomal protein L17
B5P37_RS03195	COG0202	RNA polymerase activity
B5P37_RS03200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5P37_RS03210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5P37_RS03225	COG0201	protein transport
B5P37_RS03235	COG1841	ribosomal large subunit assembly
B5P37_RS03240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5P37_RS03245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5P37_RS03250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5P37_RS03255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5P37_RS03260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5P37_RS03265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5P37_RS03270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5P37_RS03275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5P37_RS03285	COG0255	Belongs to the universal ribosomal protein uL29 family
B5P37_RS03295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5P37_RS03300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5P37_RS03305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5P37_RS03310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5P37_RS03315	COG0089	rRNA binding
B5P37_RS03320	COG0088	Forms part of the polypeptide exit tunnel
B5P37_RS03325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5P37_RS03340	COG2252	PERMEase
B5P37_RS03365	COG0436	Aminotransferase
B5P37_RS03370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5P37_RS03375	COG2348	transferase activity, transferring amino-acyl groups
B5P37_RS03400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5P37_RS03405	COG0746	molybdenum cofactor guanylyltransferase activity
B5P37_RS03415	COG0314	molybdopterin synthase activity
B5P37_RS03425	COG0303	'Molybdopterin
B5P37_RS03435	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5P37_RS03440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5P37_RS03445	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5P37_RS03450	COG4149	molybdate abc transporter
B5P37_RS03455	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5P37_RS03460	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B5P37_RS03465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5P37_RS03470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B5P37_RS03475	COG1609	Transcriptional regulator
B5P37_RS03490	COG1268	BioY protein
B5P37_RS03500	COG2832	Protein of unknown function (DUF454)
B5P37_RS03505	COG1960	acyl-CoA dehydrogenase activity
B5P37_RS03525	COG3942	CHAP domain
B5P37_RS03560	COG1757	Na H antiporter
B5P37_RS03575	COG3942	CHAP domain
B5P37_RS03580	COG2076	Multidrug Resistance protein
B5P37_RS03585	COG2076	Multidrug Resistance protein
B5P37_RS03590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5P37_RS03600	COG0488	(ABC) transporter
B5P37_RS03615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5P37_RS03625	COG4193	domain, Protein
B5P37_RS03640	COG3383	formate dehydrogenase (NAD+) activity
B5P37_RS03645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B5P37_RS03660	COG1316	TRANSCRIPTIONal
B5P37_RS03670	COG2378	regulation of single-species biofilm formation
B5P37_RS03680	COG1113	amino acid transport
B5P37_RS03700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5P37_RS03715	COG0385	Bile acid
B5P37_RS03735	COG1473	amidohydrolase
B5P37_RS03745	COG1228	amidohydrolase
B5P37_RS03750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B5P37_RS03755	COG0583	DNA-binding transcription factor activity
B5P37_RS03760	COG1266	CAAX protease self-immunity
B5P37_RS03775	COG2258	MOSC domain
B5P37_RS03785	COG2017	converts alpha-aldose to the beta-anomer
B5P37_RS03790	COG1742	UPF0060 membrane protein
B5P37_RS03795	COG1668	transmembrane transport
B5P37_RS03800	COG4152	abc transporter atp-binding protein
B5P37_RS03810	COG2094	Belongs to the DNA glycosylase MPG family
B5P37_RS03815	COG1757	Na H antiporter
B5P37_RS03820	COG3250	beta-galactosidase activity
B5P37_RS03825	COG2207	Transcriptional regulator
B5P37_RS03830	COG0786	glutamate:sodium symporter activity
B5P37_RS03835	COG0523	cobalamin synthesis protein
B5P37_RS03840	COG1304	FMN binding
B5P37_RS03870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B5P37_RS03900	COG0577	efflux transmembrane transporter activity
B5P37_RS03925	COG1620	l-lactate permease
B5P37_RS03935	COG0604	alcohol dehydrogenase
B5P37_RS03940	COG2814	Major facilitator Superfamily
B5P37_RS03965	COG1283	sodium-dependent phosphate transmembrane transporter activity
B5P37_RS03995	COG0697	spore germination
B5P37_RS04000	COG1363	Peptidase, m42
B5P37_RS04005	COG1473	amidohydrolase
B5P37_RS04010	COG0039	L-malate dehydrogenase activity
B5P37_RS04020	COG4187	Peptidase family M20/M25/M40
B5P37_RS04025	COG2223	nitrite transmembrane transporter activity
B5P37_RS04030	COG2197	response regulator
B5P37_RS04035	COG4585	Histidine kinase
B5P37_RS04045	COG2181	nitrate reductase activity
B5P37_RS04055	COG1140	nitrate reductase beta subunit
B5P37_RS04060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B5P37_RS04075	COG3328	transposase activity
B5P37_RS04080	COG0737	Belongs to the 5'-nucleotidase family
B5P37_RS04085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5P37_RS04085	COG1648	precorrin-2 dehydrogenase activity
B5P37_RS04095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5P37_RS04100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5P37_RS04100	COG1648	precorrin-2 dehydrogenase activity
B5P37_RS04110	COG0454	-acetyltransferase
B5P37_RS04115	COG2116	formate transmembrane transporter activity
B5P37_RS04120	COG0471	metal ion transport
B5P37_RS04150	COG1760	l-serine dehydratase
B5P37_RS04155	COG1760	l-serine dehydratase
B5P37_RS04170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5P37_RS04175	COG0601	transmembrane transport
B5P37_RS04180	COG4608	Belongs to the ABC transporter superfamily
B5P37_RS04185	COG0444	Belongs to the ABC transporter superfamily
B5P37_RS04190	COG0747	negative chemotaxis
B5P37_RS04195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5P37_RS04200	COG0601	transmembrane transport
B5P37_RS04205	COG4608	Belongs to the ABC transporter superfamily
B5P37_RS04210	COG0444	Belongs to the ABC transporter superfamily
B5P37_RS04215	COG4166	transmembrane transport
B5P37_RS04220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5P37_RS04240	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B5P37_RS04245	COG1929	Belongs to the glycerate kinase type-1 family
B5P37_RS04250	COG3764	Sortase (surface protein transpeptidase)
B5P37_RS04255	COG2271	Major facilitator Superfamily
B5P37_RS04260	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B5P37_RS04265	COG1115	amino acid carrier protein
B5P37_RS04270	COG0346	lactoylglutathione lyase activity
B5P37_RS04275	COG1132	(ABC) transporter
B5P37_RS04280	COG1132	(ABC) transporter
B5P37_RS04290	COG0159	tryptophan synthase activity
B5P37_RS04295	COG0133	tryptophan synthase activity
B5P37_RS04300	COG0135	phosphoribosylanthranilate isomerase activity
B5P37_RS04305	COG0134	indole-3-glycerol-phosphate synthase activity
B5P37_RS04315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5P37_RS04315	COG0512	Glutamine amidotransferase of anthranilate synthase
B5P37_RS04320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5P37_RS04325	COG3961	Belongs to the TPP enzyme family
B5P37_RS04335	COG3835	regulator
B5P37_RS04355	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS04370	COG0235	Class ii aldolase
B5P37_RS04375	COG1070	Carbohydrate kinase
B5P37_RS04385	COG1349	DNA-binding transcription factor activity
B5P37_RS04410	COG2226	methyltransferase
B5P37_RS04410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5P37_RS04410	COG0596	Alpha beta hydrolase
B5P37_RS04430	COG2357	RelA SpoT domain protein
B5P37_RS04435	COG2357	RelA SpoT domain protein
B5P37_RS04440	COG0778	Nitroreductase
B5P37_RS04465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B5P37_RS04490	COG0717	Belongs to the dCTP deaminase family
B5P37_RS04495	COG4607	ABC-type enterochelin transport system periplasmic component
B5P37_RS04500	COG4604	ABC transporter, ATP-binding protein
B5P37_RS04505	COG4605	iron ion homeostasis
B5P37_RS04510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS04515	COG0804	urea catabolic process
B5P37_RS04520	COG0832	Belongs to the urease beta subunit family
B5P37_RS04530	COG4413	Urea transporter
B5P37_RS04570	COG0778	Nitroreductase
B5P37_RS04580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5P37_RS04585	COG0463	Glycosyl transferase, family 2
B5P37_RS04585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B5P37_RS04610	COG0747	negative chemotaxis
B5P37_RS04615	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5P37_RS04620	COG2226	methyltransferase
B5P37_RS04630	COG3942	CHAP domain
B5P37_RS04630	COG1705	Flagellar rod assembly protein muramidase FlgJ
B5P37_RS04655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5P37_RS04655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5P37_RS04655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5P37_RS04660	COG0789	Transcriptional regulator
B5P37_RS04660	COG4978	Transcriptional regulator
B5P37_RS04665	COG0596	Alpha beta hydrolase
B5P37_RS04675	COG2824	Alkylphosphonate utilization operon protein PhnA
B5P37_RS04680	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B5P37_RS04685	COG1461	Dihydroxyacetone kinase
B5P37_RS04690	COG2376	Dihydroxyacetone kinase
B5P37_RS04745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B5P37_RS04750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5P37_RS04760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5P37_RS04775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5P37_RS04780	COG0107	imidazoleglycerol-phosphate synthase activity
B5P37_RS04790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5P37_RS04805	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS04810	COG1510	regulation of RNA biosynthetic process
B5P37_RS04835	COG1785	Belongs to the alkaline phosphatase family
B5P37_RS04845	COG1396	sequence-specific DNA binding
B5P37_RS04850	COG2807	transmembrane transport
B5P37_RS04855	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B5P37_RS04860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5P37_RS04865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5P37_RS04885	COG1957	nucleoside hydrolase
B5P37_RS04890	COG3250	beta-galactosidase activity
B5P37_RS04895	COG0477	Major facilitator Superfamily
B5P37_RS04900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B5P37_RS04905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B5P37_RS04910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B5P37_RS04930	COG2271	Major facilitator Superfamily
B5P37_RS04945	COG0191	fructose-bisphosphate aldolase activity
B5P37_RS04950	COG0673	inositol 2-dehydrogenase activity
B5P37_RS04955	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5P37_RS04965	COG0673	inositol 2-dehydrogenase activity
B5P37_RS04970	COG3962	Belongs to the TPP enzyme family
B5P37_RS04975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5P37_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS04990	COG1349	DNA-binding transcription factor activity
B5P37_RS04995	COG3588	fructose-bisphosphate aldolase
B5P37_RS05000	COG0803	Belongs to the bacterial solute-binding protein 9 family
B5P37_RS05010	COG1328	CTP reductase activity
B5P37_RS05015	COG3037	sugar-specific permease SgaT UlaA
B5P37_RS05025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5P37_RS05030	COG3711	transcriptional antiterminator
B5P37_RS05085	COG1879	ABC-type sugar transport system periplasmic component
B5P37_RS05090	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5P37_RS05095	COG1129	ABC transporter
B5P37_RS05100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5P37_RS05105	COG1609	Transcriptional regulator
B5P37_RS05115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5P37_RS05125	COG1116	anion transmembrane transporter activity
B5P37_RS05135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5P37_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
B5P37_RS05155	COG1960	acyl-CoA dehydrogenase activity
B5P37_RS05165	COG0183	Belongs to the thiolase family
B5P37_RS05190	COG1073	alpha beta
B5P37_RS05215	COG3391	amine dehydrogenase activity
B5P37_RS05220	COG0579	oxidoreductase
B5P37_RS05230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B5P37_RS05235	COG1755	Isoprenylcysteine carboxyl methyltransferase
B5P37_RS05250	COG0431	NADPH-dependent FMN reductase
B5P37_RS05265	COG2814	Major facilitator Superfamily
B5P37_RS05280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5P37_RS05290	COG1136	(ABC) transporter
B5P37_RS05295	COG0577	efflux transmembrane transporter activity
B5P37_RS05310	COG0436	Aminotransferase
B5P37_RS05355	COG0783	Belongs to the Dps family
B5P37_RS05365	COG0753	catalase activity
B5P37_RS05370	COG2318	DinB family
B5P37_RS05380	COG0076	glutamate decarboxylase activity
B5P37_RS05390	COG1309	transcriptional regulator
B5P37_RS05395	COG1335	isochorismatase
B5P37_RS05400	COG2814	Major facilitator Superfamily
B5P37_RS05405	COG2910	NAD(P)H-binding
B5P37_RS05410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B5P37_RS05425	COG0156	8-amino-7-oxononanoate synthase activity
B5P37_RS05430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5P37_RS05435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5P37_RS05440	COG1620	l-lactate permease
B5P37_RS05475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5P37_RS05485	COG3716	PTS system mannose fructose sorbose family IID component
B5P37_RS05490	COG3715	PTS system
B5P37_RS05495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5P37_RS05505	COG3684	Belongs to the aldolase LacD family
B5P37_RS05510	COG1105	Belongs to the carbohydrate kinase PfkB family
B5P37_RS05515	COG2222	sugar isomerase
B5P37_RS05520	COG2188	Transcriptional regulator
B5P37_RS05525	COG0366	Alpha amylase catalytic
B5P37_RS05535	COG3961	Belongs to the TPP enzyme family
B5P37_RS05540	COG0346	lactoylglutathione lyase activity
B5P37_RS05550	COG0490	domain, Protein
B5P37_RS05555	COG0475	glutathione-regulated potassium exporter activity
B5P37_RS05585	COG2814	Major facilitator Superfamily
B5P37_RS05605	COG2188	Transcriptional regulator
B5P37_RS05620	COG1454	alcohol dehydrogenase
B5P37_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS05635	COG3426	butyrate kinase activity
B5P37_RS05640	COG0280	phosphate acetyltransferase
B5P37_RS05685	COG0653	protein targeting
B5P37_RS05695	COG1073	alpha beta
B5P37_RS05705	COG0201	protein transport
B5P37_RS05715	COG1827	regulation of RNA biosynthetic process
B5P37_RS05720	COG1104	cysteine desulfurase activity
B5P37_RS05725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5P37_RS05730	COG0157	Belongs to the NadC ModD family
B5P37_RS05735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5P37_RS05740	COG0586	Pfam SNARE associated Golgi protein
B5P37_RS05745	COG0745	RESPONSE REGULATOR receiver
B5P37_RS05750	COG2205	protein histidine kinase activity
B5P37_RS05760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B5P37_RS05765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B5P37_RS05805	COG1131	(ABC) transporter
B5P37_RS05840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5P37_RS05850	COG4863	YycH protein
B5P37_RS05855	COG5002	protein histidine kinase activity
B5P37_RS05860	COG0745	RESPONSE REGULATOR receiver
B5P37_RS05875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B5P37_RS05880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5P37_RS05885	COG0305	Participates in initiation and elongation during chromosome replication
B5P37_RS05890	COG0359	binds to the 23S rRNA
B5P37_RS05895	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B5P37_RS05900	COG4241	membrane
B5P37_RS05915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B5P37_RS05930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5P37_RS05940	COG0187	DNA topoisomerase II activity
B5P37_RS05945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5P37_RS05950	COG2501	S4 domain
B5P37_RS05960	COG0592	DNA-directed DNA polymerase activity
B5P37_RS05965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5P37_RS05975	COG0594	ribonuclease P activity
B5P37_RS05980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B5P37_RS05985	COG0445	tRNA wobble uridine modification
B5P37_RS05990	COG0357	Ribosomal RNA small subunit methyltransferase G
B5P37_RS05995	COG1475	DNA binding
B5P37_RS06000	COG0400	carboxylic ester hydrolase activity
B5P37_RS06005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B5P37_RS06010	COG0346	lactoylglutathione lyase activity
B5P37_RS06015	COG1846	Transcriptional regulator
B5P37_RS06020	COG2388	GCN5-related N-acetyl-transferase
B5P37_RS06030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B5P37_RS06060	COG0646	methionine synthase
B5P37_RS06060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5P37_RS06065	COG0626	cystathionine gamma-synthase activity
B5P37_RS06070	COG0626	cystathionine gamma-synthase activity
B5P37_RS06080	COG1475	DNA binding
B5P37_RS06085	COG0668	transmembrane transport
B5P37_RS06090	COG4481	Protein conserved in bacteria
B5P37_RS06095	COG0012	GTP binding
B5P37_RS06105	COG4974	Belongs to the 'phage' integrase family
B5P37_RS06160	COG0018	arginyl-trna synthetase
B5P37_RS06180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5P37_RS06205	COG0753	catalase activity
B5P37_RS06215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5P37_RS06230	COG0450	alkyl hydroperoxide reductase
B5P37_RS06235	COG0778	Nitroreductase
B5P37_RS06255	COG0577	efflux transmembrane transporter activity
B5P37_RS06255	COG1136	(ABC) transporter
B5P37_RS06260	COG1823	symporter activity
B5P37_RS06265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5P37_RS06270	COG5183	chlorophyll binding
B5P37_RS06285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5P37_RS06290	COG2233	PERMEase
B5P37_RS06295	COG0516	GMP reductase activity
B5P37_RS06295	COG0517	IMP dehydrogenase activity
B5P37_RS06300	COG0519	Catalyzes the synthesis of GMP from XMP
B5P37_RS06300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5P37_RS06305	COG0582	viral genome integration into host DNA
B5P37_RS06365	COG3620	sequence-specific DNA binding
B5P37_RS06380	COG1525	nuclease
B5P37_RS06390	COG0584	glycerophosphoryl diester phosphodiesterase
B5P37_RS06415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B5P37_RS06440	COG0747	negative chemotaxis
B5P37_RS06445	COG0601	transmembrane transport
B5P37_RS06450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5P37_RS06455	COG0444	Belongs to the ABC transporter superfamily
B5P37_RS06460	COG1124	(ABC) transporter
B5P37_RS06490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B5P37_RS06495	COG3942	CHAP domain
B5P37_RS06495	COG1388	LysM domain
B5P37_RS06570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5P37_RS06570	COG0574	Belongs to the PEP-utilizing enzyme family
B5P37_RS06575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B5P37_RS06585	COG0733	neurotransmitter:sodium symporter activity
B5P37_RS06590	COG2272	Belongs to the type-B carboxylesterase lipase family
B5P37_RS06595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B5P37_RS06600	COG0626	cystathionine gamma-synthase activity
B5P37_RS06630	COG0583	DNA-binding transcription factor activity
B5P37_RS06640	COG0493	'glutamate synthase
B5P37_RS06650	COG1263	PTS System
B5P37_RS06650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5P37_RS06655	COG0366	Alpha amylase catalytic
B5P37_RS06660	COG2188	Transcriptional regulator
B5P37_RS06680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5P37_RS06685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5P37_RS06705	COG1982	Orn Lys Arg decarboxylase major
B5P37_RS06710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5P37_RS06715	COG3870	Protein conserved in bacteria
B5P37_RS06720	COG0470	DNA polymerase III
B5P37_RS06725	COG1774	PSP1 C-terminal conserved region
B5P37_RS06735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B5P37_RS06740	COG2827	Endonuclease containing a URI domain
B5P37_RS06745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5P37_RS06755	COG0084	hydrolase, TatD family'
B5P37_RS06760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B5P37_RS06770	COG4466	Protein conserved in bacteria
B5P37_RS06775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B5P37_RS06780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5P37_RS06785	COG0251	oxidation-reduction process
B5P37_RS06795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5P37_RS06800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B5P37_RS06810	COG0193	aminoacyl-tRNA hydrolase activity
B5P37_RS06820	COG2244	polysaccharide biosynthetic process
B5P37_RS06825	COG3956	TIGRFAM MazG family protein
B5P37_RS06830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B5P37_RS06840	COG1098	S1 RNA binding domain
B5P37_RS06855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5P37_RS06860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B5P37_RS06880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5P37_RS06885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5P37_RS06985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5P37_RS06990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B5P37_RS06995	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B5P37_RS07020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5P37_RS07025	COG4463	regulation of RNA biosynthetic process
B5P37_RS07030	COG3880	PFAM UvrB UvrC protein
B5P37_RS07035	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B5P37_RS07040	COG0542	response to heat
B5P37_RS07045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B5P37_RS07050	COG4956	integral membrane protein (PIN domain superfamily)
B5P37_RS07055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5P37_RS07065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5P37_RS07070	COG1045	serine acetyltransferase
B5P37_RS07075	COG0215	cysteine-tRNA ligase activity
B5P37_RS07080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B5P37_RS07100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5P37_RS07105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5P37_RS07110	COG0250	Participates in transcription elongation, termination and antitermination
B5P37_RS07115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5P37_RS07125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5P37_RS07135	COG2813	Specifically methylates the guanine in position
B5P37_RS07140	COG0085	RNA polymerase activity
B5P37_RS07145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5P37_RS07155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5P37_RS07160	COG0049	tRNA binding
B5P37_RS07165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5P37_RS07175	COG1473	amidohydrolase
B5P37_RS07185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5P37_RS07200	COG0546	phosphoglycolate phosphatase activity
B5P37_RS07205	COG1428	Deoxynucleoside kinase
B5P37_RS07210	COG1428	Deoxynucleoside kinase
B5P37_RS07225	COG0561	phosphatase activity
B5P37_RS07265	COG0577	efflux transmembrane transporter activity
B5P37_RS07265	COG1136	(ABC) transporter
B5P37_RS07275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B5P37_RS07290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5P37_RS07290	COG2190	(PTS) system
B5P37_RS07290	COG1263	PTS System
B5P37_RS07300	COG0363	glucosamine-6-phosphate deaminase activity
B5P37_RS07305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5P37_RS07310	COG0318	PFAM AMP-dependent synthetase and ligase
B5P37_RS07315	COG0183	Belongs to the thiolase family
B5P37_RS07335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5P37_RS07345	COG2363	Small membrane protein
B5P37_RS07350	COG0531	amino acid
B5P37_RS07365	COG1566	PFAM secretion protein HlyD family protein
B5P37_RS07370	COG2814	Major facilitator Superfamily
B5P37_RS07375	COG0095	Lipoate-protein ligase
B5P37_RS07400	COG0471	metal ion transport
B5P37_RS07440	COG4844	belongs to the
B5P37_RS07450	COG1078	dGTPase activity
B5P37_RS07470	COG0805	protein transport
B5P37_RS07475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5P37_RS07480	COG0672	)-iron permease
B5P37_RS07485	COG2837	iron assimilation
B5P37_RS07490	COG2822	iron ion transport
B5P37_RS07495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5P37_RS07500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS07510	COG0596	Alpha beta hydrolase
B5P37_RS07555	COG0803	Belongs to the bacterial solute-binding protein 9 family
B5P37_RS07565	COG1121	(ABC) transporter
B5P37_RS07575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS07580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5P37_RS07585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5P37_RS07595	COG2423	ornithine cyclodeaminase activity
B5P37_RS07600	COG4264	IucA IucC family
B5P37_RS07605	COG2814	Major facilitator Superfamily
B5P37_RS07610	COG4264	IucA IucC family
B5P37_RS07615	COG4264	IucA IucC family
B5P37_RS07625	COG0019	diaminopimelate decarboxylase activity
B5P37_RS07630	COG1475	DNA binding
B5P37_RS07640	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B5P37_RS07650	COG1682	transport, permease protein
B5P37_RS07655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B5P37_RS07660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B5P37_RS07665	COG1686	Belongs to the peptidase S11 family
B5P37_RS07670	COG1132	(ABC) transporter
B5P37_RS07690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5P37_RS07695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B5P37_RS07700	COG1120	ATPase activity
B5P37_RS07710	COG0477	Major facilitator Superfamily
B5P37_RS07715	COG3949	Membrane
B5P37_RS07730	COG0745	RESPONSE REGULATOR receiver
B5P37_RS07740	COG1136	(ABC) transporter
B5P37_RS07745	COG0577	efflux transmembrane transporter activity
B5P37_RS07750	COG1392	Phosphate transport regulator
B5P37_RS07755	COG0306	phosphate transporter
B5P37_RS07760	COG1388	LysM domain
B5P37_RS07760	COG3942	CHAP domain
B5P37_RS07770	COG0352	thiamine-phosphate diphosphorylase activity
B5P37_RS07780	COG2022	thiamine diphosphate biosynthetic process
B5P37_RS07790	COG0217	transcriptional regulatory protein
B5P37_RS07805	COG0583	DNA-binding transcription factor activity
B5P37_RS07810	COG2814	Major facilitator Superfamily
B5P37_RS07835	COG1611	Belongs to the LOG family
B5P37_RS07845	COG1968	undecaprenyl-diphosphatase activity
B5P37_RS07850	COG4988	ABC transporter
B5P37_RS07855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B5P37_RS07870	COG4989	oxidoreductase activity
B5P37_RS07880	COG0039	L-malate dehydrogenase activity
B5P37_RS07895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B5P37_RS07900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B5P37_RS07905	COG1349	DNA-binding transcription factor activity
B5P37_RS07910	COG1105	Belongs to the carbohydrate kinase PfkB family
B5P37_RS07915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5P37_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5P37_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5P37_RS07920	COG1253	flavin adenine dinucleotide binding
B5P37_RS07925	COG0463	Glycosyl transferase, family 2
B5P37_RS07930	COG2261	transglycosylase associated protein
B5P37_RS07940	COG0602	queuosine metabolic process
B5P37_RS07945	COG0720	synthase
B5P37_RS07955	COG0512	Glutamine amidotransferase of anthranilate synthase
B5P37_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5P37_RS07960	COG0512	Glutamine amidotransferase of anthranilate synthase
B5P37_RS07985	COG1368	sulfuric ester hydrolase activity
B5P37_RS07990	COG0488	(ABC) transporter
B5P37_RS07995	COG0514	ATP-dependent DNA helicase (RecQ)
B5P37_RS08000	COG0517	IMP dehydrogenase activity
B5P37_RS08000	COG1125	glycine betaine transport
B5P37_RS08005	COG1174	glycine betaine transport
B5P37_RS08010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5P37_RS08020	COG3104	oligopeptide transport
B5P37_RS08025	COG3104	oligopeptide transport
B5P37_RS08045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5P37_RS08050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5P37_RS08060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5P37_RS08075	COG3118	belongs to the thioredoxin family
B5P37_RS08080	COG1929	Belongs to the glycerate kinase type-1 family
B5P37_RS08085	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5P37_RS08110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5P37_RS08115	COG1739	Uncharacterized protein family UPF0029
B5P37_RS08125	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B5P37_RS08140	COG0653	protein targeting
B5P37_RS08155	COG1733	regulation of RNA biosynthetic process
B5P37_RS08160	COG0778	Nitroreductase
B5P37_RS08190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B5P37_RS08200	COG0110	maltose O-acetyltransferase activity
B5P37_RS08215	COG1660	Displays ATPase and GTPase activities
B5P37_RS08220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B5P37_RS08225	COG1481	regulation of sporulation
B5P37_RS08235	COG0740	serine-type endopeptidase activity
B5P37_RS08270	COG0126	phosphoglycerate kinase activity
B5P37_RS08275	COG0149	triose-phosphate isomerase activity
B5P37_RS08280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5P37_RS08285	COG0148	phosphopyruvate hydratase activity
B5P37_RS08295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5P37_RS08300	COG1647	Serine aminopeptidase, S33
B5P37_RS08305	COG0557	exoribonuclease II activity
B5P37_RS08310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B5P37_RS08325	COG1396	sequence-specific DNA binding
B5P37_RS08445	COG1764	response to oxidative stress
B5P37_RS08455	COG0710	3-dehydroquinate dehydratase activity
B5P37_RS08465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5P37_RS08470	COG1393	Belongs to the ArsC family
B5P37_RS08480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B5P37_RS08485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5P37_RS08490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5P37_RS08495	COG2011	ABC-type metal ion transport system permease component
B5P37_RS08500	COG1464	Belongs to the NlpA lipoprotein family
B5P37_RS08505	COG1464	Belongs to the NlpA lipoprotein family
B5P37_RS08515	COG0396	ATPase activity
B5P37_RS08520	COG0719	Fe-S assembly protein
B5P37_RS08530	COG0822	iron-sulfur transferase activity
B5P37_RS08535	COG0719	Fe-S assembly protein
B5P37_RS08590	COG1136	(ABC) transporter
B5P37_RS08615	COG1801	Protein of unknown function DUF72
B5P37_RS08620	COG0730	response to heat
B5P37_RS08625	COG0737	Belongs to the 5'-nucleotidase family
B5P37_RS08630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5P37_RS08635	COG4470	Protein conserved in bacteria
B5P37_RS08645	COG2445	Protein of unknown function DUF86
B5P37_RS08650	COG0647	UMP catabolic process
B5P37_RS08655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5P37_RS08660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5P37_RS08665	COG4837	Protein of unknown function (DUF1462)
B5P37_RS08675	COG1252	NADH dehydrogenase
B5P37_RS08680	COG4844	belongs to the
B5P37_RS08685	COG0316	Belongs to the HesB IscA family
B5P37_RS08690	COG1252	NADH dehydrogenase
B5P37_RS08695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5P37_RS08700	COG2056	Na+-H+ antiporter family
B5P37_RS08710	COG1320	monovalent cation:proton antiporter activity
B5P37_RS08715	COG2212	antiporter activity
B5P37_RS08720	COG1863	multisubunit Na H antiporter MnhE subunit
B5P37_RS08725	COG0651	ATP synthesis coupled electron transport
B5P37_RS08730	COG1006	Multisubunit Na H antiporter MnhC subunit
B5P37_RS08735	COG2111	Na H antiporter
B5P37_RS08740	COG2111	Na H antiporter
B5P37_RS08740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5P37_RS08750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5P37_RS08760	COG1278	Cold shock
B5P37_RS08765	COG1098	S1 RNA binding domain
B5P37_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
B5P37_RS08785	COG0584	glycerophosphoryl diester phosphodiesterase
B5P37_RS08795	COG0137	argininosuccinate synthase activity
B5P37_RS08815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B5P37_RS08820	COG1074	ATP-dependent DNA helicase activity
B5P37_RS08825	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5P37_RS08835	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5P37_RS08840	COG0561	phosphatase activity
B5P37_RS08855	COG0542	response to heat
B5P37_RS08860	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B5P37_RS08885	COG0601	transmembrane transport
B5P37_RS08890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5P37_RS08895	COG0444	Belongs to the ABC transporter superfamily
B5P37_RS08900	COG4608	Belongs to the ABC transporter superfamily
B5P37_RS08905	COG4166	transmembrane transport
B5P37_RS08910	COG0180	Tryptophanyl-tRNA synthetase
B5P37_RS08915	COG1393	Belongs to the ArsC family
B5P37_RS08920	COG4862	establishment of competence for transformation
B5P37_RS08930	COG1164	Oligoendopeptidase f
B5P37_RS08980	COG1122	ATPase activity
B5P37_RS08995	COG2346	COG2346, Truncated hemoglobins
B5P37_RS09010	COG2357	RelA SpoT domain protein
B5P37_RS09020	COG0564	pseudouridine synthase activity
B5P37_RS09025	COG2239	Acts as a magnesium transporter
B5P37_RS09030	COG0475	glutathione-regulated potassium exporter activity
B5P37_RS09030	COG0569	domain protein
B5P37_RS09050	COG3279	Response regulator of the LytR AlgR family
B5P37_RS09055	COG0628	permease
B5P37_RS09065	COG2382	esterase
B5P37_RS09070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B5P37_RS09075	COG2814	Major facilitator Superfamily
B5P37_RS09080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5P37_RS09085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5P37_RS09095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B5P37_RS09100	COG0861	Integral membrane protein TerC family
B5P37_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5P37_RS09110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5P37_RS09115	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B5P37_RS09120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5P37_RS09125	COG1696	Membrane protein involved in D-alanine export
B5P37_RS09140	COG0737	Belongs to the 5'-nucleotidase family
B5P37_RS09145	COG4932	domain protein
B5P37_RS09145	COG3266	domain, Protein
B5P37_RS09145	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B5P37_RS09200	COG4873	Protein conserved in bacteria
B5P37_RS09220	COG4619	ABC transporter
B5P37_RS09225	COG0390	transport system, permease component
B5P37_RS09230	COG1575	Belongs to the MenA family. Type 1 subfamily
B5P37_RS09235	COG1169	isochorismate synthase
B5P37_RS09240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B5P37_RS09245	COG2267	carboxylic ester hydrolase activity
B5P37_RS09250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5P37_RS09255	COG0436	Aminotransferase
B5P37_RS09260	COG3594	Acyltransferase
B5P37_RS09285	COG1316	TRANSCRIPTIONal
B5P37_RS09290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5P37_RS09295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5P37_RS09300	COG1682	transport, permease protein
B5P37_RS09305	COG0297	glycogen (starch) synthase activity
B5P37_RS09315	COG1215	transferase activity, transferring glycosyl groups
B5P37_RS09320	COG0438	transferase activity, transferring glycosyl groups
B5P37_RS09340	COG1134	teichoic acid transport
B5P37_RS09345	COG0438	transferase activity, transferring glycosyl groups
B5P37_RS09355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B5P37_RS09360	COG1845	cytochrome c oxidase, subunit III
B5P37_RS09370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5P37_RS09380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5P37_RS09380	COG1017	nitric oxide dioxygenase activity
B5P37_RS09385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5P37_RS09390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5P37_RS09395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B5P37_RS09405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5P37_RS09415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5P37_RS09420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5P37_RS09425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5P37_RS09435	COG0138	bifunctional purine biosynthesis protein purh
B5P37_RS09440	COG0151	Belongs to the GarS family
B5P37_RS09450	COG4172	Belongs to the ABC transporter superfamily
B5P37_RS09465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5P37_RS09475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5P37_RS09490	COG1271	oxidase subunit
B5P37_RS09495	COG1294	oxidase, subunit
B5P37_RS09500	COG0569	domain protein
B5P37_RS09505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B5P37_RS09510	COG5503	Protein of unknown function (DUF1447)
B5P37_RS09550	COG4476	Belongs to the UPF0223 family
B5P37_RS09565	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5P37_RS09570	COG1177	transmembrane transport
B5P37_RS09575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5P37_RS09590	COG4493	Belongs to the UPF0637 family
B5P37_RS09595	COG0483	inositol monophosphate 1-phosphatase activity
B5P37_RS09605	COG1217	gtp-binding protein TYPA
B5P37_RS09610	COG1902	pentaerythritol trinitrate reductase activity
B5P37_RS09620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5P37_RS09625	COG4838	Belongs to the UPF0358 family
B5P37_RS09630	COG0772	Belongs to the SEDS family
B5P37_RS09640	COG1612	heme a metabolic process
B5P37_RS09665	COG3679	Belongs to the UPF0342 family
B5P37_RS09670	COG0584	glycerophosphoryl diester phosphodiesterase
B5P37_RS09675	COG4471	UPF0298 protein
B5P37_RS09685	COG0742	ribosomal rna small subunit methyltransferase
B5P37_RS09690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5P37_RS09705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5P37_RS09710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5P37_RS09715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5P37_RS09720	COG0072	phenylalanine-tRNA ligase activity
B5P37_RS09745	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5P37_RS09760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B5P37_RS09760	COG1796	DNA polymerase
B5P37_RS09770	COG3118	belongs to the thioredoxin family
B5P37_RS09775	COG0322	excinuclease ABC activity
B5P37_RS09780	COG2009	succinate dehydrogenase
B5P37_RS09785	COG1053	succinate dehydrogenase
B5P37_RS09790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5P37_RS09830	COG0582	viral genome integration into host DNA
B5P37_RS09860	COG5632	N-Acetylmuramoyl-L-alanine amidase
B5P37_RS09860	COG1388	LysM domain
B5P37_RS09900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5P37_RS09910	COG1011	Hydrolase
B5P37_RS09915	COG0454	-acetyltransferase
B5P37_RS09920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B5P37_RS09925	COG2001	Belongs to the MraZ family
B5P37_RS09930	COG0275	rRNA processing
B5P37_RS09935	COG4839	cell division protein FtsL
B5P37_RS09940	COG0768	penicillin binding
B5P37_RS09955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5P37_RS09965	COG0849	cell division
B5P37_RS09970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5P37_RS09975	COG1496	oxidoreductase activity
B5P37_RS09980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B5P37_RS09985	COG1799	cell septum assembly
B5P37_RS09990	COG0762	integral membrane protein
B5P37_RS10000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5P37_RS10005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5P37_RS10015	COG0673	inositol 2-dehydrogenase activity
B5P37_RS10025	COG3599	regulation of cell shape
B5P37_RS10035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5P37_RS10040	COG0564	pseudouridine synthase activity
B5P37_RS10045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B5P37_RS10050	COG2233	PERMEase
B5P37_RS10065	COG0505	Belongs to the CarA family
B5P37_RS10070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5P37_RS10080	COG0167	dihydroorotate dehydrogenase activity
B5P37_RS10090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5P37_RS10135	COG1758	RNA polymerase activity
B5P37_RS10165	COG3328	transposase activity
B5P37_RS10185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5P37_RS10190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B5P37_RS10200	COG0242	peptide deformylase activity
B5P37_RS10205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5P37_RS10210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5P37_RS10210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5P37_RS10215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5P37_RS10220	COG0631	protein serine/threonine phosphatase activity
B5P37_RS10230	COG2124	cytochrome p450
B5P37_RS10235	COG1162	GTPase activity
B5P37_RS10240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5P37_RS10245	COG1564	THIamine pyrophosphokinase
B5P37_RS10255	COG1302	Protein conserved in bacteria
B5P37_RS10265	COG1760	l-serine dehydratase
B5P37_RS10270	COG1760	l-serine dehydratase
B5P37_RS10275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5P37_RS10280	COG1349	DNA-binding transcription factor activity
B5P37_RS10285	COG0416	fatty acid biosynthetic process
B5P37_RS10300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5P37_RS10305	COG0571	ribonuclease III activity
B5P37_RS10310	COG1196	nuclear chromosome segregation
B5P37_RS10315	COG0552	protein localization to endoplasmic reticulum
B5P37_RS10320	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B5P37_RS10325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5P37_RS10335	COG0228	four-way junction DNA binding
B5P37_RS10340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5P37_RS10345	COG0336	Belongs to the RNA methyltransferase TrmD family
B5P37_RS10375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5P37_RS10385	COG0045	succinate-CoA ligase (ADP-forming) activity
B5P37_RS10395	COG0758	DNA mediated transformation
B5P37_RS10400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5P37_RS10405	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B5P37_RS10410	COG4974	Belongs to the 'phage' integrase family
B5P37_RS10415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5P37_RS10420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5P37_RS10425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B5P37_RS10430	COG0052	Belongs to the universal ribosomal protein uS2 family
B5P37_RS10435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5P37_RS10440	COG0528	UMP kinase activity
B5P37_RS10445	COG0233	cytoplasmic translational termination
B5P37_RS10450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5P37_RS10455	COG4589	Belongs to the CDS family
B5P37_RS10460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5P37_RS10470	COG0442	prolyl-tRNA aminoacylation
B5P37_RS10480	COG0779	Required for maturation of 30S ribosomal subunits
B5P37_RS10485	COG0195	Participates in both transcription termination and antitermination
B5P37_RS10490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B5P37_RS10495	COG1358	cellular component organization or biogenesis
B5P37_RS10500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5P37_RS10515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B5P37_RS10525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B5P37_RS10530	COG1447	Phosphotransferase system cellobiose-specific component IIA
B5P37_RS10535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5P37_RS10540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5P37_RS10545	COG0196	riboflavin kinase activity
B5P37_RS10555	COG1185	polyribonucleotide nucleotidyltransferase activity
B5P37_RS10560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B5P37_RS10570	COG2188	Transcriptional regulator
B5P37_RS10575	COG0612	Peptidase, M16
B5P37_RS10580	COG0612	Peptidase, M16
B5P37_RS10585	COG0300	oxidoreductase activity
B5P37_RS10610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5P37_RS10615	COG1418	mRNA catabolic process
B5P37_RS10635	COG1692	metallophosphoesterase
B5P37_RS10640	COG0674	pyruvate-flavodoxin oxidoreductase activity
B5P37_RS10640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B5P37_RS10645	COG1013	pyruvate-flavodoxin oxidoreductase activity
B5P37_RS10655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5P37_RS10660	COG4550	Control of competence regulator ComK, YlbF/YmcA
B5P37_RS10675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5P37_RS10680	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B5P37_RS10685	COG1619	proteins homologs of microcin C7 resistance protein MccF
B5P37_RS10690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5P37_RS10700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5P37_RS10710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5P37_RS10715	COG1923	regulation of RNA biosynthetic process
B5P37_RS10720	COG0386	Belongs to the glutathione peroxidase family
B5P37_RS10725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5P37_RS10730	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B5P37_RS10735	COG0789	Transcriptional regulator
B5P37_RS10775	COG0488	(ABC) transporter
B5P37_RS10790	COG1116	anion transmembrane transporter activity
B5P37_RS10795	COG0584	glycerophosphoryl diester phosphodiesterase
B5P37_RS10825	COG1525	nuclease
B5P37_RS10850	COG0460	homoserine dehydrogenase
B5P37_RS10855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5P37_RS10860	COG0083	homoserine kinase activity
B5P37_RS10865	COG0561	phosphatase activity
B5P37_RS10875	COG0833	amino acid
B5P37_RS10885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5P37_RS10890	COG0516	GMP reductase activity
B5P37_RS10895	COG2340	Cysteine-rich secretory protein family
B5P37_RS10910	COG4224	UPF0291 protein
B5P37_RS10920	COG3763	UPF0154 protein
B5P37_RS10930	COG4846	Membrane protein involved in cytochrome C biogenesis
B5P37_RS10935	COG0420	3'-5' exonuclease activity
B5P37_RS10940	COG0419	ATPase involved in DNA repair
B5P37_RS10945	COG3328	transposase activity
B5P37_RS10950	COG1970	mechanosensitive ion channel activity
B5P37_RS10955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5P37_RS10965	COG0824	Thioesterase
B5P37_RS10970	COG4841	protein insertion into membrane
B5P37_RS10975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B5P37_RS10985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5P37_RS10990	COG1115	amino acid carrier protein
B5P37_RS10995	COG3711	transcriptional antiterminator
B5P37_RS11005	COG0628	permease
B5P37_RS11035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5P37_RS11045	COG1363	Peptidase, m42
B5P37_RS11075	COG2996	Protein conserved in bacteria
B5P37_RS11080	COG0488	(ABC) transporter
B5P37_RS11085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5P37_RS11090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5P37_RS11095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5P37_RS11100	COG2171	N-acyltransferase activity
B5P37_RS11105	COG1473	amidohydrolase
B5P37_RS11120	COG1278	Cold shock
B5P37_RS11140	COG3853	Toxic anion resistance protein (TelA)
B5P37_RS11145	COG1114	Component of the transport system for branched-chain amino acids
B5P37_RS11150	COG4548	von Willebrand factor, type A
B5P37_RS11155	COG0714	Associated with various cellular activities
B5P37_RS11175	COG0567	Dehydrogenase, E1 component
B5P37_RS11180	COG5002	protein histidine kinase activity
B5P37_RS11190	COG0671	phosphoesterase, PA-phosphatase related
B5P37_RS11195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5P37_RS11205	COG0793	Belongs to the peptidase S41A family
B5P37_RS11210	COG4479	Belongs to the UPF0346 family
B5P37_RS11250	COG1413	lyase activity
B5P37_RS11260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B5P37_RS11270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5P37_RS11275	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B5P37_RS11280	COG2962	Rard protein
B5P37_RS11285	COG0116	Belongs to the methyltransferase superfamily
B5P37_RS11295	COG3599	regulation of cell shape
B5P37_RS11300	COG4474	Belongs to the UPF0398 family
B5P37_RS11310	COG3331	DNA recombination
B5P37_RS11315	COG4499	WXG100 protein secretion system (Wss), protein YukC
B5P37_RS11315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5P37_RS11325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5P37_RS11330	COG3935	DnaD domain protein
B5P37_RS11335	COG0017	Asparaginyl-tRNA synthetase
B5P37_RS11345	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B5P37_RS11345	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B5P37_RS11350	COG0617	tRNA 3'-terminal CCA addition
B5P37_RS11355	COG0438	transferase activity, transferring glycosyl groups
B5P37_RS11360	COG1694	Mazg nucleotide pyrophosphohydrolase
B5P37_RS11365	COG2738	Putative neutral zinc metallopeptidase
B5P37_RS11370	COG4347	Protein of unknown function (DUF1405)
B5P37_RS11375	COG5582	Belongs to the UPF0302 family
B5P37_RS11385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5P37_RS11390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5P37_RS11395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5P37_RS11400	COG0105	UTP biosynthetic process
B5P37_RS11405	COG0142	geranyltranstransferase activity
B5P37_RS11410	COG2226	methyltransferase
B5P37_RS11435	COG0539	negative regulation of cytoplasmic translation
B5P37_RS11445	COG0252	asparaginase activity
B5P37_RS11470	COG0492	ferredoxin-NADP+ reductase activity
B5P37_RS11480	COG0514	ATP-dependent DNA helicase (RecQ)
B5P37_RS11490	COG1141	Ferredoxin
B5P37_RS11500	COG5002	protein histidine kinase activity
B5P37_RS11505	COG0745	RESPONSE REGULATOR receiver
B5P37_RS11510	COG1187	pseudouridine synthase activity
B5P37_RS11515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5P37_RS11520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B5P37_RS11535	COG0735	belongs to the Fur family
B5P37_RS11540	COG0494	nUDIX hydrolase
B5P37_RS11545	COG0667	Aldo Keto reductase
B5P37_RS11550	COG4221	oxidoreductase activity
B5P37_RS11555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5P37_RS11560	COG1234	tRNA 3'-trailer cleavage
B5P37_RS11565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5P37_RS11580	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5P37_RS11590	COG4129	membrane
B5P37_RS11600	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5P37_RS11605	COG0022	dehydrogenase e1 component
B5P37_RS11610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5P37_RS11615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5P37_RS11620	COG3426	butyrate kinase activity
B5P37_RS11625	COG0280	phosphate acetyltransferase
B5P37_RS11630	COG0497	DNA recombination
B5P37_RS11635	COG1438	arginine binding
B5P37_RS11650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5P37_RS11670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5P37_RS11675	COG1302	Protein conserved in bacteria
B5P37_RS11680	COG0439	Biotin carboxylase
B5P37_RS11685	COG0511	ligase activity, forming carbon-carbon bonds
B5P37_RS11690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5P37_RS11695	COG0006	proline dipeptidase activity
B5P37_RS11710	COG0095	Lipoate-protein ligase
B5P37_RS11715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5P37_RS11720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5P37_RS11735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5P37_RS11760	COG1609	Transcriptional regulator