locus-tag	class	description
BJG88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BJG88_RS00010	COG0592	DNA-directed DNA polymerase activity
BJG88_RS00015	COG2501	S4 domain
BJG88_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BJG88_RS00025	COG0187	DNA topoisomerase II activity
BJG88_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BJG88_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BJG88_RS00040	COG2986	histidine ammonia-lyase
BJG88_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BJG88_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BJG88_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BJG88_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BJG88_RS00075	COG0359	binds to the 23S rRNA
BJG88_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
BJG88_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BJG88_RS00090	COG1819	glycosyl
BJG88_RS00110	COG0477	Major facilitator Superfamily
BJG88_RS00115	COG0745	RESPONSE REGULATOR receiver
BJG88_RS00120	COG5002	protein histidine kinase activity
BJG88_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BJG88_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BJG88_RS00200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BJG88_RS00250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BJG88_RS00255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BJG88_RS00270	COG0640	Transcriptional regulator
BJG88_RS00300	COG0446	pyridine nucleotide-disulphide oxidoreductase
BJG88_RS00395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BJG88_RS00405	COG1653	transport
BJG88_RS00410	COG1175	transmembrane transport
BJG88_RS00415	COG0395	ABC-type sugar transport system, permease component
BJG88_RS00435	COG1846	Transcriptional regulator
BJG88_RS00445	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BJG88_RS00450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BJG88_RS00455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BJG88_RS00460	COG1845	cytochrome c oxidase, subunit III
BJG88_RS00465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BJG88_RS00495	COG1349	DNA-binding transcription factor activity
BJG88_RS00505	COG1070	Carbohydrate kinase
BJG88_RS00510	COG4806	L-rhamnose isomerase
BJG88_RS00515	COG0235	Class ii aldolase
BJG88_RS00520	COG3254	rhamnose metabolic process
BJG88_RS00525	COG2814	Major facilitator Superfamily
BJG88_RS00530	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS00565	COG4565	transcriptional regulatory protein
BJG88_RS00570	COG3493	citrate carrier protein
BJG88_RS00580	COG1846	Transcriptional regulator
BJG88_RS00585	COG3961	Belongs to the TPP enzyme family
BJG88_RS00605	COG1942	4-Oxalocrotonate Tautomerase
BJG88_RS00620	COG1733	regulation of RNA biosynthetic process
BJG88_RS00625	COG1902	pentaerythritol trinitrate reductase activity
BJG88_RS00640	COG1705	Flagellar rod assembly protein muramidase FlgJ
BJG88_RS00640	COG3942	CHAP domain
BJG88_RS00650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BJG88_RS00685	COG0702	epimerase
BJG88_RS00690	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BJG88_RS00725	COG0415	Belongs to the DNA photolyase family
BJG88_RS00730	COG1335	isochorismatase
BJG88_RS00735	COG1522	sequence-specific DNA binding
BJG88_RS00740	COG1733	regulation of RNA biosynthetic process
BJG88_RS00765	COG0583	DNA-binding transcription factor activity
BJG88_RS00770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS00770	COG2190	(PTS) system
BJG88_RS00770	COG1263	PTS System
BJG88_RS00775	COG2723	6-phospho-beta-galactosidase activity
BJG88_RS00790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BJG88_RS00795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BJG88_RS00800	COG1595	DNA-templated transcription, initiation
BJG88_RS00810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BJG88_RS00820	COG1737	Transcriptional regulator
BJG88_RS00825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BJG88_RS00830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BJG88_RS00835	COG1447	Phosphotransferase system cellobiose-specific component IIA
BJG88_RS00855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BJG88_RS00860	COG0471	metal ion transport
BJG88_RS00865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BJG88_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS00875	COG0583	DNA-binding transcription factor activity
BJG88_RS00890	COG3711	transcriptional antiterminator
BJG88_RS00895	COG2190	(PTS) system
BJG88_RS00895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS00895	COG1263	PTS System
BJG88_RS00900	COG0438	transferase activity, transferring glycosyl groups
BJG88_RS00905	COG0438	transferase activity, transferring glycosyl groups
BJG88_RS00910	COG1876	peptidase activity
BJG88_RS00920	COG0402	S-adenosylhomocysteine deaminase activity
BJG88_RS00925	COG2723	6-phospho-beta-galactosidase activity
BJG88_RS00930	COG2723	6-phospho-beta-galactosidase activity
BJG88_RS00935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS00935	COG2190	(PTS) system
BJG88_RS00935	COG1263	PTS System
BJG88_RS00940	COG3711	transcriptional antiterminator
BJG88_RS00945	COG3711	transcriptional antiterminator
BJG88_RS00950	COG1309	transcriptional regulator
BJG88_RS00955	COG1511	domain protein
BJG88_RS00970	COG2207	Transcriptional regulator
BJG88_RS00975	COG2211	Major facilitator Superfamily
BJG88_RS00980	COG3250	beta-galactosidase activity
BJG88_RS00990	COG2271	Major facilitator Superfamily
BJG88_RS01000	COG3655	Transcriptional regulator
BJG88_RS01030	COG0579	oxidoreductase
BJG88_RS01035	COG5295	Hep Hag repeat protein
BJG88_RS01035	COG4932	domain protein
BJG88_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS01060	COG1063	alcohol dehydrogenase
BJG88_RS01065	COG1063	alcohol dehydrogenase
BJG88_RS01070	COG3775	system Galactitol-specific IIC component
BJG88_RS01075	COG3414	Phosphotransferase system galactitol-specific IIB component
BJG88_RS01090	COG0471	metal ion transport
BJG88_RS01105	COG2318	DinB family
BJG88_RS01110	COG1388	LysM domain
BJG88_RS01115	COG0564	pseudouridine synthase activity
BJG88_RS01120	COG1388	LysM domain
BJG88_RS01125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BJG88_RS01135	COG1054	Belongs to the UPF0176 family
BJG88_RS01150	COG1609	Transcriptional regulator
BJG88_RS01160	COG0235	Class ii aldolase
BJG88_RS01185	COG1511	domain protein
BJG88_RS01185	COG1511	domain protein
BJG88_RS01200	COG1917	Cupin 2, conserved barrel domain protein
BJG88_RS01200	COG2207	Transcriptional regulator
BJG88_RS01210	COG1328	CTP reductase activity
BJG88_RS01220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BJG88_RS01225	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BJG88_RS01225	COG3583	domain protein
BJG88_RS01225	COG4932	domain protein
BJG88_RS01230	COG0431	NADPH-dependent FMN reductase
BJG88_RS01235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS01240	COG0346	lactoylglutathione lyase activity
BJG88_RS01245	COG1136	(ABC) transporter
BJG88_RS01275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BJG88_RS01300	COG0477	Major facilitator Superfamily
BJG88_RS01310	COG2814	Major facilitator Superfamily
BJG88_RS01320	COG0584	glycerophosphoryl diester phosphodiesterase
BJG88_RS01330	COG0668	transmembrane transport
BJG88_RS01340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BJG88_RS01350	COG2211	Major facilitator Superfamily
BJG88_RS01355	COG1940	carbohydrate kinase activity
BJG88_RS01355	COG1846	Transcriptional regulator
BJG88_RS01360	COG2115	Belongs to the xylose isomerase family
BJG88_RS01365	COG1070	Carbohydrate kinase
BJG88_RS01370	COG0477	Major facilitator Superfamily
BJG88_RS01370	COG2814	Major facilitator Superfamily
BJG88_RS01380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS01410	COG0673	inositol 2-dehydrogenase activity
BJG88_RS01420	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BJG88_RS01425	COG1691	(AIR) carboxylase
BJG88_RS01430	COG1606	tRNA processing
BJG88_RS01435	COG3875	lactate racemase activity
BJG88_RS01450	COG3835	regulator
BJG88_RS01460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BJG88_RS01480	COG1476	TRANSCRIPTIONal
BJG88_RS01485	COG2807	transmembrane transport
BJG88_RS01495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BJG88_RS01500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BJG88_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS01510	COG0531	amino acid
BJG88_RS01530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BJG88_RS01535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS01540	COG1510	regulation of RNA biosynthetic process
BJG88_RS01545	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS01550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BJG88_RS01555	COG0803	Belongs to the bacterial solute-binding protein 9 family
BJG88_RS01560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BJG88_RS01570	COG0772	Belongs to the SEDS family
BJG88_RS01575	COG0463	Glycosyl transferase, family 2
BJG88_RS01575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BJG88_RS01580	COG0778	Nitroreductase
BJG88_RS01585	COG2843	Capsule synthesis protein
BJG88_RS01590	COG1957	nucleoside hydrolase
BJG88_RS01595	COG0477	Major facilitator Superfamily
BJG88_RS01615	COG1131	(ABC) transporter
BJG88_RS01620	COG2610	gluconate transmembrane transporter activity
BJG88_RS01625	COG1349	DNA-binding transcription factor activity
BJG88_RS01630	COG3842	ATPase activity
BJG88_RS01655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BJG88_RS01660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BJG88_RS01665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BJG88_RS01670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BJG88_RS01680	COG0431	NADPH-dependent FMN reductase
BJG88_RS01690	COG1414	Transcriptional regulator
BJG88_RS01700	COG1063	alcohol dehydrogenase
BJG88_RS01705	COG1620	l-lactate permease
BJG88_RS01710	COG2814	Major facilitator Superfamily
BJG88_RS01720	COG2190	(PTS) system
BJG88_RS01720	COG1263	PTS System
BJG88_RS01720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS01730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BJG88_RS01740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BJG88_RS01765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS01790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BJG88_RS01795	COG1464	Belongs to the NlpA lipoprotein family
BJG88_RS01800	COG0039	L-malate dehydrogenase activity
BJG88_RS01805	COG3711	transcriptional antiterminator
BJG88_RS01805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BJG88_RS01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BJG88_RS01815	COG1482	cell wall glycoprotein biosynthetic process
BJG88_RS01845	COG1309	transcriptional regulator
BJG88_RS01860	COG1309	transcriptional regulator
BJG88_RS01870	COG3949	Membrane
BJG88_RS01880	COG0829	nickel cation binding
BJG88_RS01885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BJG88_RS01890	COG0830	nickel cation binding
BJG88_RS01895	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BJG88_RS01900	COG0804	urea catabolic process
BJG88_RS01905	COG0832	Belongs to the urease beta subunit family
BJG88_RS01910	COG0831	urea catabolic process
BJG88_RS01915	COG4413	Urea transporter
BJG88_RS01920	COG0747	negative chemotaxis
BJG88_RS01945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BJG88_RS01960	COG0561	phosphatase activity
BJG88_RS01970	COG0167	dihydroorotate dehydrogenase activity
BJG88_RS01975	COG3001	Fructosamine kinase
BJG88_RS02040	COG1388	LysM domain
BJG88_RS02045	COG0436	Aminotransferase
BJG88_RS02055	COG2608	mercury ion transmembrane transporter activity
BJG88_RS02060	COG2217	Heavy metal translocating P-type atpase
BJG88_RS02065	COG0659	secondary active sulfate transmembrane transporter activity
BJG88_RS02070	COG1136	(ABC) transporter
BJG88_RS02075	COG0577	efflux transmembrane transporter activity
BJG88_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS02095	COG0471	metal ion transport
BJG88_RS02100	COG5505	Protein of unknown function (DUF819)
BJG88_RS02115	COG4336	lyase activity
BJG88_RS02130	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS02140	COG2409	Drug exporters of the RND superfamily
BJG88_RS02155	COG1473	amidohydrolase
BJG88_RS02175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BJG88_RS02180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS02185	COG3425	synthase
BJG88_RS02190	COG0183	Belongs to the thiolase family
BJG88_RS02200	COG3386	PFAM SMP-30 Gluconolaconase
BJG88_RS02205	COG1757	Na H antiporter
BJG88_RS02210	COG0583	DNA-binding transcription factor activity
BJG88_RS02225	COG0028	Belongs to the TPP enzyme family
BJG88_RS02230	COG1288	antiporter activity
BJG88_RS02245	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BJG88_RS02260	COG0657	acetylesterase activity
BJG88_RS02275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BJG88_RS02285	COG2843	Capsule synthesis protein
BJG88_RS02295	COG3949	Membrane
BJG88_RS02315	COG1129	ABC transporter
BJG88_RS02325	COG1609	Transcriptional regulator
BJG88_RS02335	COG1070	Carbohydrate kinase
BJG88_RS02340	COG1063	alcohol dehydrogenase
BJG88_RS02360	COG3764	Sortase (surface protein transpeptidase)
BJG88_RS02365	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BJG88_RS02370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BJG88_RS02380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BJG88_RS02385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BJG88_RS02390	COG0561	phosphatase activity
BJG88_RS02395	COG0778	Nitroreductase
BJG88_RS02405	COG2514	catechol 2,3-dioxygenase activity
BJG88_RS02410	COG1132	(ABC) transporter
BJG88_RS02415	COG1132	(ABC) transporter
BJG88_RS02430	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS02435	COG1846	Transcriptional regulator
BJG88_RS02440	COG0346	lactoylglutathione lyase activity
BJG88_RS02445	COG0346	lactoylglutathione lyase activity
BJG88_RS02450	COG0400	carboxylic ester hydrolase activity
BJG88_RS02455	COG3949	Membrane
BJG88_RS02460	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BJG88_RS02465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BJG88_RS02470	COG0586	Pfam SNARE associated Golgi protein
BJG88_RS02475	COG2271	Major facilitator Superfamily
BJG88_RS02485	COG3527	Alpha-acetolactate decarboxylase
BJG88_RS02490	COG1289	transmembrane transporter activity
BJG88_RS02505	COG4876	unkown
BJG88_RS02510	COG2357	RelA SpoT domain protein
BJG88_RS02515	COG1802	Transcriptional regulator
BJG88_RS02520	COG1070	Carbohydrate kinase
BJG88_RS02525	COG2610	gluconate transmembrane transporter activity
BJG88_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS02535	COG3949	Membrane
BJG88_RS02545	COG2211	Major facilitator Superfamily
BJG88_RS02550	COG3250	beta-galactosidase activity
BJG88_RS02570	COG2211	Major facilitator Superfamily
BJG88_RS02575	COG1904	glucuronate isomerase
BJG88_RS02580	COG1312	Catalyzes the dehydration of D-mannonate
BJG88_RS02600	COG4221	oxidoreductase activity
BJG88_RS02610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BJG88_RS02620	COG0107	imidazoleglycerol-phosphate synthase activity
BJG88_RS02625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BJG88_RS02630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BJG88_RS02635	COG0131	Imidazoleglycerol-phosphate dehydratase
BJG88_RS02640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BJG88_RS02645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BJG88_RS02650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BJG88_RS02660	COG3048	D-serine ammonia-lyase activity
BJG88_RS02665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BJG88_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS02680	COG1363	Peptidase, m42
BJG88_RS02690	COG0069	glutamate synthase activity
BJG88_RS02700	COG4619	ABC transporter
BJG88_RS02705	COG0390	transport system, permease component
BJG88_RS02710	COG2814	Major facilitator Superfamily
BJG88_RS02715	COG2851	Citrate transporter
BJG88_RS02720	COG0531	amino acid
BJG88_RS02725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BJG88_RS02735	COG3246	L-lysine catabolic process to acetate
BJG88_RS02740	COG1250	3-hydroxyacyl-CoA dehydrogenase
BJG88_RS02755	COG1174	glycine betaine transport
BJG88_RS02765	COG1174	glycine betaine transport
BJG88_RS02780	COG4187	Peptidase family M20/M25/M40
BJG88_RS02800	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BJG88_RS02830	COG2814	Major facilitator Superfamily
BJG88_RS02840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BJG88_RS02845	COG1388	LysM domain
BJG88_RS02850	COG0588	phosphoglycerate mutase activity
BJG88_RS02860	COG2814	Major facilitator Superfamily
BJG88_RS02885	COG2353	YceI-like domain
BJG88_RS02895	COG1695	Transcriptional regulator
BJG88_RS02920	COG2116	formate transmembrane transporter activity
BJG88_RS02925	COG0454	-acetyltransferase
BJG88_RS02935	COG1648	precorrin-2 dehydrogenase activity
BJG88_RS02935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BJG88_RS02940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BJG88_RS02945	COG2146	nitrite reductase [NAD(P)H] activity
BJG88_RS02950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BJG88_RS02955	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BJG88_RS02960	COG1140	nitrate reductase beta subunit
BJG88_RS02970	COG2181	nitrate reductase activity
BJG88_RS02980	COG4585	Histidine kinase
BJG88_RS03005	COG1846	Transcriptional regulator
BJG88_RS03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS03045	COG1263	PTS System
BJG88_RS03055	COG1283	sodium-dependent phosphate transmembrane transporter activity
BJG88_RS03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS03065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS03070	COG1288	antiporter activity
BJG88_RS03075	COG1349	DNA-binding transcription factor activity
BJG88_RS03080	COG1063	alcohol dehydrogenase
BJG88_RS03085	COG2376	Dihydroxyacetone kinase
BJG88_RS03095	COG0698	ribose 5-phosphate isomerase
BJG88_RS03115	COG0492	ferredoxin-NADP+ reductase activity
BJG88_RS03125	COG2814	Major facilitator Superfamily
BJG88_RS03130	COG0604	alcohol dehydrogenase
BJG88_RS03145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BJG88_RS03150	COG1620	l-lactate permease
BJG88_RS03155	COG0438	transferase activity, transferring glycosyl groups
BJG88_RS03165	COG5002	protein histidine kinase activity
BJG88_RS03165	COG3850	Histidine kinase
BJG88_RS03170	COG0745	RESPONSE REGULATOR receiver
BJG88_RS03175	COG0577	efflux transmembrane transporter activity
BJG88_RS03180	COG1136	(ABC) transporter
BJG88_RS03195	COG4640	response to antibiotic
BJG88_RS03200	COG2814	Major facilitator Superfamily
BJG88_RS03210	COG1566	PFAM secretion protein HlyD family protein
BJG88_RS03215	COG2814	Major facilitator Superfamily
BJG88_RS03250	COG1304	FMN binding
BJG88_RS03255	COG0786	glutamate:sodium symporter activity
BJG88_RS03260	COG1695	Transcriptional regulator
BJG88_RS03275	COG1757	Na H antiporter
BJG88_RS03280	COG2094	Belongs to the DNA glycosylase MPG family
BJG88_RS03285	COG3152	Membrane
BJG88_RS03290	COG1069	ribulokinase activity
BJG88_RS03295	COG4152	abc transporter atp-binding protein
BJG88_RS03300	COG1668	transmembrane transport
BJG88_RS03305	COG2017	converts alpha-aldose to the beta-anomer
BJG88_RS03310	COG2258	MOSC domain
BJG88_RS03315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BJG88_RS03320	COG1266	CAAX protease self-immunity
BJG88_RS03325	COG0010	Belongs to the arginase family
BJG88_RS03330	COG0583	DNA-binding transcription factor activity
BJG88_RS03340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BJG88_RS03345	COG1228	amidohydrolase
BJG88_RS03350	COG0659	secondary active sulfate transmembrane transporter activity
BJG88_RS03355	COG1473	amidohydrolase
BJG88_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS03365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BJG88_RS03385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS03385	COG1263	PTS System
BJG88_RS03395	COG0385	Bile acid
BJG88_RS03400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BJG88_RS03425	COG1113	amino acid transport
BJG88_RS03430	COG1785	Belongs to the alkaline phosphatase family
BJG88_RS03440	COG1263	PTS System
BJG88_RS03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS03445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BJG88_RS03470	COG0483	inositol monophosphate 1-phosphatase activity
BJG88_RS03475	COG1316	TRANSCRIPTIONal
BJG88_RS03480	COG3383	formate dehydrogenase (NAD+) activity
BJG88_RS03505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BJG88_RS03515	COG2076	Multidrug Resistance protein
BJG88_RS03520	COG3942	CHAP domain
BJG88_RS03535	COG1757	Na H antiporter
BJG88_RS03545	COG3942	CHAP domain
BJG88_RS03570	COG0765	amino acid transport
BJG88_RS03575	COG0765	amino acid transport
BJG88_RS03585	COG1126	abc transporter atp-binding protein
BJG88_RS03590	COG1960	acyl-CoA dehydrogenase activity
BJG88_RS03595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BJG88_RS03600	COG1268	BioY protein
BJG88_RS03610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BJG88_RS03615	COG1609	Transcriptional regulator
BJG88_RS03620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BJG88_RS03625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BJG88_RS03630	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BJG88_RS03635	COG0725	ABC transporter, periplasmic molybdate-binding protein
BJG88_RS03640	COG4149	molybdate abc transporter
BJG88_RS03645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BJG88_RS03655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BJG88_RS03660	COG0521	Mo-molybdopterin cofactor biosynthetic process
BJG88_RS03665	COG0315	cyclic pyranopterin monophosphate synthase activity
BJG88_RS03690	COG0746	molybdenum cofactor guanylyltransferase activity
BJG88_RS03695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BJG88_RS03705	COG2814	Major facilitator Superfamily
BJG88_RS03725	COG2348	transferase activity, transferring amino-acyl groups
BJG88_RS03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BJG88_RS03755	COG4975	Glucose uptake
BJG88_RS03765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BJG88_RS03765	COG0551	DNA topoisomerase type I activity
BJG88_RS03770	COG2252	PERMEase
BJG88_RS03780	COG0051	transcription antitermination factor activity, RNA binding
BJG88_RS03785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BJG88_RS03790	COG0088	Forms part of the polypeptide exit tunnel
BJG88_RS03795	COG0089	rRNA binding
BJG88_RS03800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BJG88_RS03805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BJG88_RS03810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BJG88_RS03815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BJG88_RS03820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BJG88_RS03825	COG0255	Belongs to the universal ribosomal protein uL29 family
BJG88_RS03830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BJG88_RS03835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BJG88_RS03840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BJG88_RS03845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BJG88_RS03850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BJG88_RS03855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BJG88_RS03860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BJG88_RS03865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BJG88_RS03870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BJG88_RS03875	COG1841	ribosomal large subunit assembly
BJG88_RS03880	COG0200	Binds to the 23S rRNA
BJG88_RS03885	COG0201	protein transport
BJG88_RS03890	COG0563	adenylate kinase activity
BJG88_RS03900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BJG88_RS03905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BJG88_RS03915	COG0202	RNA polymerase activity
BJG88_RS03920	COG0203	ribosomal protein L17
BJG88_RS03925	COG1122	ATPase activity
BJG88_RS03930	COG1122	ATPase activity
BJG88_RS03940	COG0101	tRNA pseudouridine synthase activity
BJG88_RS03945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BJG88_RS03960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS03965	COG2130	NADP-dependent
BJG88_RS03970	COG0604	alcohol dehydrogenase
BJG88_RS03975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS03990	COG1302	Protein conserved in bacteria
BJG88_RS04005	COG4264	IucA IucC family
BJG88_RS04010	COG3457	Alanine racemase
BJG88_RS04015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BJG88_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BJG88_RS04025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BJG88_RS04030	COG3314	Sporulation integral membrane protein YlbJ
BJG88_RS04035	COG2329	Antibiotic biosynthesis monooxygenase
BJG88_RS04045	COG1988	membrane-bound metal-dependent
BJG88_RS04050	COG4284	Utp--glucose-1-phosphate uridylyltransferase
BJG88_RS04055	COG1272	protein, Hemolysin III
BJG88_RS04070	COG2814	Major facilitator Superfamily
BJG88_RS04075	COG0489	protein tyrosine kinase activity
BJG88_RS04130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BJG88_RS04140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BJG88_RS04145	COG0246	Mannitol dehydrogenase
BJG88_RS04155	COG3711	transcriptional antiterminator
BJG88_RS04160	COG2213	PTS system mannitol-specific
BJG88_RS04175	COG1119	ATPase activity
BJG88_RS04205	COG0702	epimerase
BJG88_RS04210	COG2186	Transcriptional regulator
BJG88_RS04215	COG1482	cell wall glycoprotein biosynthetic process
BJG88_RS04225	COG2855	membrane
BJG88_RS04240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BJG88_RS04245	COG0783	Belongs to the Dps family
BJG88_RS04250	COG0813	purine-nucleoside phosphorylase activity
BJG88_RS04255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BJG88_RS04260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BJG88_RS04265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BJG88_RS04275	COG1854	S-ribosylhomocysteine lyase activity
BJG88_RS04295	COG5146	pantothenate kinase activity
BJG88_RS04300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BJG88_RS04305	COG3343	RNA polymerase activity
BJG88_RS04310	COG0504	CTP synthase activity
BJG88_RS04325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BJG88_RS04335	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS04340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BJG88_RS04345	COG0254	rRNA binding
BJG88_RS04350	COG1435	thymidine kinase activity
BJG88_RS04355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BJG88_RS04360	COG2890	protein-(glutamine-N5) methyltransferase activity
BJG88_RS04365	COG0009	L-threonylcarbamoyladenylate synthase
BJG88_RS04370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BJG88_RS04375	COG4475	Protein of unknown function (DUF436)
BJG88_RS04380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BJG88_RS04385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BJG88_RS04390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BJG88_RS04400	COG0356	it plays a direct role in the translocation of protons across the membrane
BJG88_RS04405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BJG88_RS04410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BJG88_RS04415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BJG88_RS04420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BJG88_RS04425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BJG88_RS04430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BJG88_RS04435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BJG88_RS04445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BJG88_RS04450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BJG88_RS04460	COG0629	single-stranded DNA binding
BJG88_RS04465	COG1388	LysM domain
BJG88_RS04470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BJG88_RS04480	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BJG88_RS04485	COG0352	thiamine-phosphate diphosphorylase activity
BJG88_RS04490	COG0706	membrane insertase activity
BJG88_RS04495	COG1418	mRNA catabolic process
BJG88_RS04505	COG1937	Protein conserved in bacteria
BJG88_RS04525	COG0772	Belongs to the SEDS family
BJG88_RS04530	COG1181	Belongs to the D-alanine--D-alanine ligase family
BJG88_RS04535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BJG88_RS04540	COG0513	Belongs to the DEAD box helicase family
BJG88_RS04550	COG3428	Bacterial PH domain
BJG88_RS04560	COG0736	holo-[acyl-carrier-protein] synthase activity
BJG88_RS04565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BJG88_RS04575	COG2337	Toxic component of a toxin-antitoxin (TA) module
BJG88_RS04580	COG2208	phosphoserine phosphatase activity
BJG88_RS04595	COG1191	sigma factor activity
BJG88_RS04600	COG2183	response to ionizing radiation
BJG88_RS04605	COG3091	SprT-like family
BJG88_RS04635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BJG88_RS04640	COG0066	3-isopropylmalate dehydratase activity
BJG88_RS04645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BJG88_RS04650	COG0473	3-isopropylmalate dehydrogenase activity
BJG88_RS04655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BJG88_RS04660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BJG88_RS04665	COG0440	acetolactate synthase activity
BJG88_RS04670	COG0028	Belongs to the TPP enzyme family
BJG88_RS04675	COG0129	dihydroxy-acid dehydratase activity
BJG88_RS04680	COG0802	atpase or kinase
BJG88_RS04685	COG1214	PFAM Peptidase M22, glycoprotease
BJG88_RS04690	COG0456	acetyltransferase
BJG88_RS04695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BJG88_RS04715	COG0488	(ABC) transporter
BJG88_RS04720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BJG88_RS04725	COG2391	methyltransferase activity
BJG88_RS04730	COG0425	Belongs to the sulfur carrier protein TusA family
BJG88_RS04735	COG1609	Transcriptional regulator
BJG88_RS04740	COG1621	beta-fructofuranosidase activity
BJG88_RS04750	COG3279	Response regulator of the LytR AlgR family
BJG88_RS04755	COG3290	protein histidine kinase activity
BJG88_RS04765	COG4512	PFAM Accessory gene regulator B
BJG88_RS04770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BJG88_RS04790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BJG88_RS04795	COG0459	protein refolding
BJG88_RS04800	COG0582	viral genome integration into host DNA
BJG88_RS04920	COG1725	Transcriptional regulator
BJG88_RS04935	COG1131	(ABC) transporter
BJG88_RS04980	COG2706	6-phosphogluconolactonase activity
BJG88_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS04990	COG1227	inorganic diphosphatase activity
BJG88_RS04995	COG1335	isochorismatase
BJG88_RS05005	COG0471	metal ion transport
BJG88_RS05010	COG0077	Prephenate dehydratase
BJG88_RS05020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BJG88_RS05025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BJG88_RS05030	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BJG88_RS05040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BJG88_RS05045	COG4496	protein, YerC YecD
BJG88_RS05060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BJG88_RS05065	COG4851	CamS sex pheromone cAM373 precursor
BJG88_RS05070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BJG88_RS05075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BJG88_RS05080	COG0154	amidase activity
BJG88_RS05085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BJG88_RS05090	COG1597	lipid kinase activity
BJG88_RS05095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BJG88_RS05105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BJG88_RS05115	COG1528	Iron-storage protein
BJG88_RS05130	COG4129	membrane
BJG88_RS05135	COG0024	Methionine aminopeptidase
BJG88_RS05150	COG4585	Histidine kinase
BJG88_RS05155	COG2197	response regulator
BJG88_RS05160	COG1295	ribonuclease BN
BJG88_RS05170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BJG88_RS05175	COG4840	Belongs to the UPF0435 family
BJG88_RS05180	COG2309	aminopeptidase activity
BJG88_RS05185	COG1607	acyl-coa hydrolase
BJG88_RS05190	COG0535	radical SAM domain protein
BJG88_RS05200	COG0693	protein deglycase activity
BJG88_RS05205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BJG88_RS05210	COG2137	regulation of response to DNA damage stimulus
BJG88_RS05220	COG1134	teichoic acid transport
BJG88_RS05230	COG1988	membrane-bound metal-dependent
BJG88_RS05235	COG1194	a g-specific adenine glycosylase
BJG88_RS05240	COG3557	Belongs to the UPF0374 family
BJG88_RS05250	COG4129	membrane
BJG88_RS05255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BJG88_RS05260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BJG88_RS05270	COG0735	belongs to the Fur family
BJG88_RS05435	COG0765	amino acid transport
BJG88_RS05440	COG1126	abc transporter atp-binding protein
BJG88_RS05445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BJG88_RS05455	COG0363	glucosamine-6-phosphate deaminase activity
BJG88_RS05470	COG0114	fumarate hydratase activity
BJG88_RS05475	COG0564	pseudouridine synthase activity
BJG88_RS05480	COG4585	Histidine kinase
BJG88_RS05480	COG2203	Gaf domain
BJG88_RS05485	COG2197	response regulator
BJG88_RS05490	COG1301	dicarboxylic acid transport
BJG88_RS05505	COG0788	formyltetrahydrofolate deformylase activity
BJG88_RS05515	COG4399	Belongs to the UPF0754 family
BJG88_RS05520	COG3679	Belongs to the UPF0342 family
BJG88_RS05525	COG0420	3'-5' exonuclease activity
BJG88_RS05530	COG4717	serine-type aminopeptidase activity
BJG88_RS05540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BJG88_RS05555	COG0537	adenosine 5'-monophosphoramidase activity
BJG88_RS05560	COG1131	(ABC) transporter
BJG88_RS05565	COG4473	ABC transporter
BJG88_RS05575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BJG88_RS05580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BJG88_RS05585	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BJG88_RS05590	COG3545	Serine hydrolase
BJG88_RS05655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BJG88_RS05665	COG1506	peptidase
BJG88_RS05675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BJG88_RS05680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BJG88_RS05690	COG0656	L-ascorbic acid biosynthetic process
BJG88_RS05695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BJG88_RS05700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BJG88_RS05710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BJG88_RS05730	COG1595	DNA-templated transcription, initiation
BJG88_RS05755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BJG88_RS05755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BJG88_RS05760	COG0307	riboflavin synthase, alpha
BJG88_RS05765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BJG88_RS05765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BJG88_RS05770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BJG88_RS05780	COG2267	carboxylic ester hydrolase activity
BJG88_RS05785	COG0039	L-malate dehydrogenase activity
BJG88_RS05795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BJG88_RS05800	COG1242	4 iron, 4 sulfur cluster binding
BJG88_RS05805	COG2814	Major facilitator Superfamily
BJG88_RS05810	COG0495	leucyl-tRNA aminoacylation
BJG88_RS05820	COG2081	HI0933 family
BJG88_RS05825	COG2244	polysaccharide biosynthetic process
BJG88_RS05830	COG1187	pseudouridine synthase activity
BJG88_RS05840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BJG88_RS05845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BJG88_RS05850	COG0510	thiamine kinase activity
BJG88_RS05855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BJG88_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BJG88_RS05870	COG1363	Peptidase, m42
BJG88_RS05875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BJG88_RS05880	COG4848	Belongs to the UPF0354 family
BJG88_RS05885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BJG88_RS05890	COG1674	ftsk spoiiie
BJG88_RS05895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BJG88_RS05900	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BJG88_RS05910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BJG88_RS05910	COG1605	Chorismate mutase
BJG88_RS05915	COG1609	Transcriptional regulator
BJG88_RS05920	COG0123	including yeast histone deacetylase and acetoin utilization protein
BJG88_RS05925	COG0454	-acetyltransferase
BJG88_RS05930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BJG88_RS05945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BJG88_RS05950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BJG88_RS05955	COG0204	Acyl-transferase
BJG88_RS05960	COG1263	PTS System
BJG88_RS05960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS05970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BJG88_RS05975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BJG88_RS05980	COG1764	response to oxidative stress
BJG88_RS05985	COG0584	glycerophosphoryl diester phosphodiesterase
BJG88_RS05995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BJG88_RS06000	COG1956	GAF domain-containing protein
BJG88_RS06005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BJG88_RS06010	COG1104	cysteine desulfurase activity
BJG88_RS06015	COG0301	tRNA thio-modification
BJG88_RS06020	COG0730	response to heat
BJG88_RS06025	COG0616	signal peptide processing
BJG88_RS06030	COG1714	RDD family
BJG88_RS06035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BJG88_RS06045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BJG88_RS06055	COG0589	response to stress
BJG88_RS06060	COG0686	Belongs to the AlaDH PNT family
BJG88_RS06065	COG3142	Participates in the control of copper homeostasis
BJG88_RS06070	COG0006	proline dipeptidase activity
BJG88_RS06075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BJG88_RS06085	COG4109	DRTGG domain
BJG88_RS06090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BJG88_RS06100	COG0281	malic enzyme
BJG88_RS06105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BJG88_RS06110	COG0825	malonyl-CoA metabolic process
BJG88_RS06115	COG0205	6-phosphofructokinase activity
BJG88_RS06120	COG0469	pyruvate kinase activity
BJG88_RS06130	COG0372	Belongs to the citrate synthase family
BJG88_RS06135	COG0538	isocitrate dehydrogenase activity
BJG88_RS06140	COG0745	RESPONSE REGULATOR receiver
BJG88_RS06145	COG5002	protein histidine kinase activity
BJG88_RS06155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BJG88_RS06155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BJG88_RS06160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BJG88_RS06165	COG0237	dephospho-CoA kinase activity
BJG88_RS06175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BJG88_RS06185	COG1484	DNA-dependent DNA replication
BJG88_RS06190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BJG88_RS06195	COG0833	amino acid
BJG88_RS06200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BJG88_RS06205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BJG88_RS06215	COG4112	unkown
BJG88_RS06225	COG0544	peptidyl-prolyl cis-trans isomerase activity
BJG88_RS06230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BJG88_RS06235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BJG88_RS06240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BJG88_RS06245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BJG88_RS06250	COG0181	hydroxymethylbilane synthase activity
BJG88_RS06260	COG0113	porphobilinogen synthase activity
BJG88_RS06265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BJG88_RS06275	COG2818	Glycosylase
BJG88_RS06280	COG0525	valine-tRNA ligase activity
BJG88_RS06285	COG0285	dihydrofolate synthase activity
BJG88_RS06295	COG0656	L-ascorbic acid biosynthetic process
BJG88_RS06320	COG2207	Transcriptional regulator
BJG88_RS06320	COG3708	Transcriptional regulator
BJG88_RS06330	COG2003	Belongs to the UPF0758 family
BJG88_RS06360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BJG88_RS06365	COG2868	ribosomal protein
BJG88_RS06370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BJG88_RS06375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BJG88_RS06380	COG4492	Belongs to the UPF0735 family
BJG88_RS06385	COG0632	four-way junction helicase activity
BJG88_RS06390	COG2255	four-way junction helicase activity
BJG88_RS06395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BJG88_RS06400	COG0343	queuine tRNA-ribosyltransferase activity
BJG88_RS06405	COG1862	Preprotein translocase
BJG88_RS06410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BJG88_RS06410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BJG88_RS06415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BJG88_RS06415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BJG88_RS06430	COG1490	D-aminoacyl-tRNA deacylase activity
BJG88_RS06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
BJG88_RS06440	COG0124	histidyl-tRNA synthetase
BJG88_RS06445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BJG88_RS06455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BJG88_RS06460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BJG88_RS06465	COG1959	2 iron, 2 sulfur cluster binding
BJG88_RS06475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BJG88_RS06480	COG0488	(ABC) transporter
BJG88_RS06485	COG1104	cysteine desulfurase activity
BJG88_RS06490	COG0482	sulfurtransferase activity
BJG88_RS06500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BJG88_RS06505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BJG88_RS06510	COG4472	Bacterial protein of unknown function (DUF965)
BJG88_RS06515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BJG88_RS06520	COG3906	Belongs to the UPF0473 family
BJG88_RS06530	COG0826	peptidase U32
BJG88_RS06535	COG0826	peptidase U32
BJG88_RS06540	COG0572	uridine kinase
BJG88_RS06550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BJG88_RS06555	COG1984	allophanate hydrolase subunit 2
BJG88_RS06565	COG0439	Biotin carboxylase
BJG88_RS06570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BJG88_RS06575	COG1914	H( )-stimulated, divalent metal cation uptake system
BJG88_RS06580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BJG88_RS06585	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BJG88_RS06590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BJG88_RS06595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BJG88_RS06600	COG1534	Rna-binding protein
BJG88_RS06605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BJG88_RS06610	COG1713	HD superfamily hydrolase involved in NAD metabolism
BJG88_RS06615	COG0799	negative regulation of ribosome biogenesis
BJG88_RS06625	COG1555	photosystem II stabilization
BJG88_RS06630	COG2131	deaminase
BJG88_RS06640	COG1466	dna polymerase III delta subunit
BJG88_RS06645	COG0268	Binds directly to 16S ribosomal RNA
BJG88_RS06650	COG0481	GTPase activity
BJG88_RS06655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BJG88_RS06660	COG1420	regulation of RNA biosynthetic process
BJG88_RS06665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BJG88_RS06670	COG0443	Heat shock 70 kDa protein
BJG88_RS06675	COG0484	heat shock protein binding
BJG88_RS06680	COG2264	protein methyltransferase activity
BJG88_RS06685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BJG88_RS06690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BJG88_RS06695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BJG88_RS06700	COG1030	water channel activity
BJG88_RS06705	COG4864	UPF0365 protein
BJG88_RS06715	COG1702	phosphate starvation-inducible protein PhoH
BJG88_RS06720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BJG88_RS06735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BJG88_RS06740	COG1381	Involved in DNA repair and RecF pathway recombination
BJG88_RS06745	COG0423	glycine-tRNA ligase activity
BJG88_RS06750	COG0517	IMP dehydrogenase activity
BJG88_RS06755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BJG88_RS06765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BJG88_RS06770	COG2384	SAM-dependent methyltransferase
BJG88_RS06775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BJG88_RS06780	COG0513	Belongs to the DEAD box helicase family
BJG88_RS06785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BJG88_RS06790	COG1121	(ABC) transporter
BJG88_RS06795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BJG88_RS06805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BJG88_RS06810	COG0768	penicillin binding
BJG88_RS06815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BJG88_RS06820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BJG88_RS06825	COG0457	Tetratricopeptide repeat
BJG88_RS06825	COG0705	Rhomboid family
BJG88_RS06830	COG4483	Protein conserved in bacteria
BJG88_RS06835	COG1940	carbohydrate kinase activity
BJG88_RS06840	COG0011	TIGRFAM Protein of
BJG88_RS06845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BJG88_RS06850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BJG88_RS06855	COG1459	type II secretion system
BJG88_RS06860	COG4537	Required for transformation and DNA binding
BJG88_RS06885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BJG88_RS06890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BJG88_RS06895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BJG88_RS06900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BJG88_RS06905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BJG88_RS06910	COG0095	Lipoate-protein ligase
BJG88_RS06925	COG0006	proline dipeptidase activity
BJG88_RS06930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BJG88_RS06935	COG0511	ligase activity, forming carbon-carbon bonds
BJG88_RS06940	COG0439	Biotin carboxylase
BJG88_RS06945	COG1302	Protein conserved in bacteria
BJG88_RS06950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BJG88_RS06955	COG1570	exodeoxyribonuclease VII activity
BJG88_RS06970	COG1438	arginine binding
BJG88_RS06975	COG0497	DNA recombination
BJG88_RS06980	COG0280	phosphate acetyltransferase
BJG88_RS06985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BJG88_RS06990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BJG88_RS06995	COG0022	dehydrogenase e1 component
BJG88_RS07000	COG0508	dehydrogenase complex catalyzes the overall conversion of
BJG88_RS07010	COG4129	membrane
BJG88_RS07015	COG2195	Cleaves the N-terminal amino acid of tripeptides
BJG88_RS07025	COG0366	Alpha amylase catalytic
BJG88_RS07035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BJG88_RS07040	COG1234	tRNA 3'-trailer cleavage
BJG88_RS07045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BJG88_RS07055	COG0667	Aldo Keto reductase
BJG88_RS07060	COG0494	nUDIX hydrolase
BJG88_RS07065	COG0735	belongs to the Fur family
BJG88_RS07070	COG4974	Belongs to the 'phage' integrase family
BJG88_RS07080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BJG88_RS07085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BJG88_RS07090	COG1187	pseudouridine synthase activity
BJG88_RS07095	COG0745	RESPONSE REGULATOR receiver
BJG88_RS07110	COG1141	Ferredoxin
BJG88_RS07120	COG0514	ATP-dependent DNA helicase (RecQ)
BJG88_RS07130	COG0492	ferredoxin-NADP+ reductase activity
BJG88_RS07135	COG0252	asparaginase activity
BJG88_RS07140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BJG88_RS07145	COG0539	negative regulation of cytoplasmic translation
BJG88_RS07150	COG1160	GTP binding
BJG88_RS07155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BJG88_RS07170	COG2226	methyltransferase
BJG88_RS07175	COG0142	geranyltranstransferase activity
BJG88_RS07180	COG0105	UTP biosynthetic process
BJG88_RS07185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BJG88_RS07190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BJG88_RS07195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BJG88_RS07205	COG5582	Belongs to the UPF0302 family
BJG88_RS07210	COG4347	Protein of unknown function (DUF1405)
BJG88_RS07215	COG2738	Putative neutral zinc metallopeptidase
BJG88_RS07220	COG1694	Mazg nucleotide pyrophosphohydrolase
BJG88_RS07225	COG0438	transferase activity, transferring glycosyl groups
BJG88_RS07230	COG0617	tRNA 3'-terminal CCA addition
BJG88_RS07240	COG1199	ATP-dependent helicase activity
BJG88_RS07240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BJG88_RS07245	COG0017	Asparaginyl-tRNA synthetase
BJG88_RS07250	COG3935	DnaD domain protein
BJG88_RS07255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BJG88_RS07265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BJG88_RS07265	COG4499	WXG100 protein secretion system (Wss), protein YukC
BJG88_RS07270	COG3331	DNA recombination
BJG88_RS07280	COG4474	Belongs to the UPF0398 family
BJG88_RS07285	COG3599	regulation of cell shape
BJG88_RS07295	COG0116	Belongs to the methyltransferase superfamily
BJG88_RS07300	COG2962	Rard protein
BJG88_RS07310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BJG88_RS07315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BJG88_RS07320	COG0328	RNA-DNA hybrid ribonuclease activity
BJG88_RS07330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BJG88_RS07340	COG1413	lyase activity
BJG88_RS07345	COG1413	lyase activity
BJG88_RS07355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BJG88_RS07375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BJG88_RS07385	COG4479	Belongs to the UPF0346 family
BJG88_RS07390	COG0793	Belongs to the peptidase S41A family
BJG88_RS07400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BJG88_RS07405	COG0671	phosphoesterase, PA-phosphatase related
BJG88_RS07410	COG0745	RESPONSE REGULATOR receiver
BJG88_RS07415	COG5002	protein histidine kinase activity
BJG88_RS07420	COG0567	Dehydrogenase, E1 component
BJG88_RS07425	COG0508	dehydrogenase complex catalyzes the overall conversion of
BJG88_RS07430	COG1396	sequence-specific DNA binding
BJG88_RS07435	COG4977	sequence-specific DNA binding
BJG88_RS07455	COG0673	inositol 2-dehydrogenase activity
BJG88_RS07475	COG0714	Associated with various cellular activities
BJG88_RS07480	COG4548	von Willebrand factor, type A
BJG88_RS07485	COG1114	Component of the transport system for branched-chain amino acids
BJG88_RS07490	COG3853	Toxic anion resistance protein (TelA)
BJG88_RS07500	COG1254	Belongs to the acylphosphatase family
BJG88_RS07510	COG1278	Cold shock
BJG88_RS07525	COG1473	amidohydrolase
BJG88_RS07535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BJG88_RS07540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BJG88_RS07545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BJG88_RS07550	COG0527	aspartate kinase activity
BJG88_RS07560	COG0488	(ABC) transporter
BJG88_RS07565	COG2996	Protein conserved in bacteria
BJG88_RS07570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BJG88_RS07575	COG0573	inorganic phosphate transmembrane transporter activity
BJG88_RS07580	COG0581	inorganic phosphate transmembrane transporter activity
BJG88_RS07585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BJG88_RS07590	COG0704	Plays a role in the regulation of phosphate uptake
BJG88_RS07595	COG1164	Oligoendopeptidase f
BJG88_RS07605	COG0789	Transcriptional regulator
BJG88_RS07610	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BJG88_RS07615	COG0450	alkyl hydroperoxide reductase
BJG88_RS07625	COG2124	cytochrome p450
BJG88_RS07635	COG1012	belongs to the aldehyde dehydrogenase family
BJG88_RS07640	COG0667	Aldo Keto reductase
BJG88_RS07670	COG1063	alcohol dehydrogenase
BJG88_RS07680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BJG88_RS07690	COG2348	transferase activity, transferring amino-acyl groups
BJG88_RS07705	COG0159	tryptophan synthase activity
BJG88_RS07710	COG0133	tryptophan synthase activity
BJG88_RS07720	COG0134	indole-3-glycerol-phosphate synthase activity
BJG88_RS07725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BJG88_RS07730	COG0512	Glutamine amidotransferase of anthranilate synthase
BJG88_RS07735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BJG88_RS07750	COG0287	Prephenate dehydrogenase
BJG88_RS07755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BJG88_RS07760	COG1942	4-Oxalocrotonate Tautomerase
BJG88_RS07775	COG1879	ABC-type sugar transport system periplasmic component
BJG88_RS07780	COG1172	Belongs to the binding-protein-dependent transport system permease family
BJG88_RS07785	COG1129	ABC transporter
BJG88_RS07790	COG1869	D-ribose catabolic process
BJG88_RS07795	COG1609	Transcriptional regulator
BJG88_RS07805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BJG88_RS07805	COG0392	lysyltransferase activity
BJG88_RS07810	COG0628	permease
BJG88_RS07815	COG1115	amino acid carrier protein
BJG88_RS07820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BJG88_RS07830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BJG88_RS07835	COG4841	protein insertion into membrane
BJG88_RS07840	COG0824	Thioesterase
BJG88_RS07845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BJG88_RS07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS07855	COG1970	mechanosensitive ion channel activity
BJG88_RS07860	COG0419	ATPase involved in DNA repair
BJG88_RS07865	COG0420	3'-5' exonuclease activity
BJG88_RS07870	COG4846	Membrane protein involved in cytochrome C biogenesis
BJG88_RS07930	COG2856	Zn peptidase
BJG88_RS07935	COG0582	viral genome integration into host DNA
BJG88_RS07945	COG3763	UPF0154 protein
BJG88_RS07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BJG88_RS07975	COG0516	GMP reductase activity
BJG88_RS07980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BJG88_RS07985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BJG88_RS07995	COG0753	catalase activity
BJG88_RS08000	COG0833	amino acid
BJG88_RS08010	COG1522	sequence-specific DNA binding
BJG88_RS08015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BJG88_RS08035	COG0561	phosphatase activity
BJG88_RS08040	COG0083	homoserine kinase activity
BJG88_RS08045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BJG88_RS08050	COG0460	homoserine dehydrogenase
BJG88_RS08055	COG0527	aspartate kinase activity
BJG88_RS08075	COG1525	nuclease
BJG88_RS08110	COG0174	glutamine synthetase
BJG88_RS08115	COG0789	Transcriptional regulator
BJG88_RS08120	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BJG88_RS08125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BJG88_RS08130	COG0386	Belongs to the glutathione peroxidase family
BJG88_RS08135	COG1923	regulation of RNA biosynthetic process
BJG88_RS08140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BJG88_RS08150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BJG88_RS08155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BJG88_RS08160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BJG88_RS08165	COG1619	proteins homologs of microcin C7 resistance protein MccF
BJG88_RS08175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BJG88_RS08180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BJG88_RS08190	COG4550	Control of competence regulator ComK, YlbF/YmcA
BJG88_RS08195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BJG88_RS08205	COG0492	ferredoxin-NADP+ reductase activity
BJG88_RS08210	COG1959	2 iron, 2 sulfur cluster binding
BJG88_RS08220	COG1013	pyruvate-flavodoxin oxidoreductase activity
BJG88_RS08225	COG0674	pyruvate-flavodoxin oxidoreductase activity
BJG88_RS08225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BJG88_RS08230	COG1692	metallophosphoesterase
BJG88_RS08240	COG1418	mRNA catabolic process
BJG88_RS08245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BJG88_RS08250	COG1546	Belongs to the CinA family
BJG88_RS08250	COG1058	Belongs to the CinA family
BJG88_RS08270	COG0300	oxidoreductase activity
BJG88_RS08275	COG0612	Peptidase, M16
BJG88_RS08280	COG0612	Peptidase, M16
BJG88_RS08295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BJG88_RS08300	COG1185	polyribonucleotide nucleotidyltransferase activity
BJG88_RS08305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BJG88_RS08310	COG0196	riboflavin kinase activity
BJG88_RS08315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BJG88_RS08320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BJG88_RS08335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BJG88_RS08340	COG1358	cellular component organization or biogenesis
BJG88_RS08345	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BJG88_RS08350	COG0195	Participates in both transcription termination and antitermination
BJG88_RS08355	COG0779	Required for maturation of 30S ribosomal subunits
BJG88_RS08360	COG2176	DNA-directed DNA polymerase activity
BJG88_RS08365	COG0442	prolyl-tRNA aminoacylation
BJG88_RS08375	COG4589	Belongs to the CDS family
BJG88_RS08380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BJG88_RS08385	COG0233	cytoplasmic translational termination
BJG88_RS08390	COG0528	UMP kinase activity
BJG88_RS08395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BJG88_RS08400	COG0052	Belongs to the universal ribosomal protein uS2 family
BJG88_RS08405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BJG88_RS08410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BJG88_RS08415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BJG88_RS08420	COG4974	Belongs to the 'phage' integrase family
BJG88_RS08425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BJG88_RS08430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BJG88_RS08435	COG0758	DNA mediated transformation
BJG88_RS08445	COG0045	succinate-CoA ligase (ADP-forming) activity
BJG88_RS08450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BJG88_RS08460	COG4485	Bacterial membrane protein, YfhO
BJG88_RS08470	COG0335	large ribosomal subunit rRNA binding
BJG88_RS08475	COG0336	Belongs to the RNA methyltransferase TrmD family
BJG88_RS08480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BJG88_RS08485	COG0228	four-way junction DNA binding
BJG88_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS08505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BJG88_RS08510	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BJG88_RS08515	COG0552	protein localization to endoplasmic reticulum
BJG88_RS08520	COG1196	nuclear chromosome segregation
BJG88_RS08525	COG0571	ribonuclease III activity
BJG88_RS08530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BJG88_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS08545	COG0416	fatty acid biosynthetic process
BJG88_RS08550	COG1349	DNA-binding transcription factor activity
BJG88_RS08565	COG1760	l-serine dehydratase
BJG88_RS08570	COG1760	l-serine dehydratase
BJG88_RS08575	COG1461	Dihydroxyacetone kinase
BJG88_RS08580	COG1302	Protein conserved in bacteria
BJG88_RS08585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BJG88_RS08590	COG1564	THIamine pyrophosphokinase
BJG88_RS08595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BJG88_RS08600	COG1162	GTPase activity
BJG88_RS08610	COG0631	protein serine/threonine phosphatase activity
BJG88_RS08615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BJG88_RS08620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BJG88_RS08620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BJG88_RS08625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BJG88_RS08630	COG0242	peptide deformylase activity
BJG88_RS08645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BJG88_RS08650	COG1473	amidohydrolase
BJG88_RS08795	COG0740	serine-type endopeptidase activity
BJG88_RS08910	COG1484	DNA-dependent DNA replication
BJG88_RS08985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BJG88_RS08990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BJG88_RS08995	COG1758	RNA polymerase activity
BJG88_RS09000	COG0194	GDP metabolic process
BJG88_RS09015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BJG88_RS09025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BJG88_RS09030	COG0284	orotidine-5'-phosphate decarboxylase activity
BJG88_RS09035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BJG88_RS09040	COG0505	Belongs to the CarA family
BJG88_RS09050	COG0540	Belongs to the ATCase OTCase family
BJG88_RS09055	COG2233	PERMEase
BJG88_RS09060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BJG88_RS09065	COG0564	pseudouridine synthase activity
BJG88_RS09070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BJG88_RS09080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BJG88_RS09085	COG3599	regulation of cell shape
BJG88_RS09095	COG0762	integral membrane protein
BJG88_RS09100	COG1799	cell septum assembly
BJG88_RS09105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BJG88_RS09110	COG1496	oxidoreductase activity
BJG88_RS09115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BJG88_RS09120	COG0849	cell division
BJG88_RS09125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BJG88_RS09130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BJG88_RS09135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BJG88_RS09140	COG0768	penicillin binding
BJG88_RS09145	COG4839	cell division protein FtsL
BJG88_RS09150	COG0275	rRNA processing
BJG88_RS09155	COG2001	Belongs to the MraZ family
BJG88_RS09160	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BJG88_RS09165	COG0454	-acetyltransferase
BJG88_RS09170	COG1011	Hydrolase
BJG88_RS09190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS09215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BJG88_RS09220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BJG88_RS09225	COG1053	succinate dehydrogenase
BJG88_RS09230	COG2009	succinate dehydrogenase
BJG88_RS09235	COG0322	excinuclease ABC activity
BJG88_RS09240	COG3118	belongs to the thioredoxin family
BJG88_RS09245	COG1193	negative regulation of DNA recombination
BJG88_RS09250	COG1796	DNA polymerase
BJG88_RS09250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BJG88_RS09260	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BJG88_RS09265	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BJG88_RS09270	COG0072	phenylalanine-tRNA ligase activity
BJG88_RS09275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BJG88_RS09280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BJG88_RS09290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BJG88_RS09300	COG1323	Belongs to the UPF0348 family
BJG88_RS09310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BJG88_RS09315	COG0742	ribosomal rna small subunit methyltransferase
BJG88_RS09325	COG4471	UPF0298 protein
BJG88_RS09330	COG0584	glycerophosphoryl diester phosphodiesterase
BJG88_RS09335	COG3679	Belongs to the UPF0342 family
BJG88_RS09350	COG0109	protoheme IX farnesyltransferase activity
BJG88_RS09355	COG1612	heme a metabolic process
BJG88_RS09365	COG0772	Belongs to the SEDS family
BJG88_RS09370	COG4838	Belongs to the UPF0358 family
BJG88_RS09375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BJG88_RS09380	COG4896	Protein conserved in bacteria
BJG88_RS09385	COG1217	gtp-binding protein TYPA
BJG88_RS09395	COG0483	inositol monophosphate 1-phosphatase activity
BJG88_RS09400	COG4493	Belongs to the UPF0637 family
BJG88_RS09410	COG1914	H( )-stimulated, divalent metal cation uptake system
BJG88_RS09430	COG1176	ABC-type spermidine putrescine transport system, permease component I
BJG88_RS09440	COG4476	Belongs to the UPF0223 family
BJG88_RS09460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BJG88_RS09470	COG0242	peptide deformylase activity
BJG88_RS09480	COG5503	Protein of unknown function (DUF1447)
BJG88_RS09485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BJG88_RS09490	COG0569	domain protein
BJG88_RS09495	COG1294	oxidase, subunit
BJG88_RS09500	COG1271	oxidase subunit
BJG88_RS09510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BJG88_RS09515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS09525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BJG88_RS09540	COG4172	Belongs to the ABC transporter superfamily
BJG88_RS09545	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BJG88_RS09550	COG0151	Belongs to the GarS family
BJG88_RS09555	COG0138	bifunctional purine biosynthesis protein purh
BJG88_RS09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BJG88_RS09575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BJG88_RS09580	COG0047	phosphoribosylformylglycinamidine synthase activity
BJG88_RS09585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BJG88_RS09590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BJG88_RS09595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BJG88_RS09600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BJG88_RS09605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BJG88_RS09615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BJG88_RS09620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BJG88_RS09625	COG1845	cytochrome c oxidase, subunit III
BJG88_RS09630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BJG88_RS09645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BJG88_RS09650	COG1316	TRANSCRIPTIONal
BJG88_RS09675	COG3594	Acyltransferase
BJG88_RS09680	COG0436	Aminotransferase
BJG88_RS09690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BJG88_RS09695	COG2267	carboxylic ester hydrolase activity
BJG88_RS09700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BJG88_RS09705	COG1169	isochorismate synthase
BJG88_RS09710	COG1575	Belongs to the MenA family. Type 1 subfamily
BJG88_RS09720	COG2314	TM2 domain
BJG88_RS09750	COG4903	ComK protein
BJG88_RS09765	COG4873	Protein conserved in bacteria
BJG88_RS09775	COG0737	Belongs to the 5'-nucleotidase family
BJG88_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BJG88_RS09785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BJG88_RS09790	COG0861	Integral membrane protein TerC family
BJG88_RS09795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BJG88_RS09805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BJG88_RS09810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BJG88_RS09815	COG2814	Major facilitator Superfamily
BJG88_RS09820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BJG88_RS09825	COG2382	esterase
BJG88_RS09830	COG1115	amino acid carrier protein
BJG88_RS09835	COG0628	permease
BJG88_RS09845	COG0475	glutathione-regulated potassium exporter activity
BJG88_RS09845	COG0569	domain protein
BJG88_RS09850	COG2239	Acts as a magnesium transporter
BJG88_RS09855	COG0564	pseudouridine synthase activity
BJG88_RS09860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BJG88_RS09865	COG2357	RelA SpoT domain protein
BJG88_RS09875	COG4116	CYTH
BJG88_RS09880	COG2346	COG2346, Truncated hemoglobins
BJG88_RS09885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BJG88_RS09890	COG1164	Oligoendopeptidase f
BJG88_RS09900	COG4862	establishment of competence for transformation
BJG88_RS09905	COG1393	Belongs to the ArsC family
BJG88_RS09910	COG0180	Tryptophanyl-tRNA synthetase
BJG88_RS09915	COG4166	transmembrane transport
BJG88_RS09920	COG4608	Belongs to the ABC transporter superfamily
BJG88_RS09925	COG0444	Belongs to the ABC transporter superfamily
BJG88_RS09930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BJG88_RS09935	COG0601	transmembrane transport
BJG88_RS09955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BJG88_RS09995	COG0561	phosphatase activity
BJG88_RS10000	COG0446	pyridine nucleotide-disulphide oxidoreductase
BJG88_RS10020	COG0179	Fumarylacetoacetate (FAA) hydrolase
BJG88_RS10025	COG2311	Membrane
BJG88_RS10030	COG1074	ATP-dependent DNA helicase activity
BJG88_RS10035	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BJG88_RS10050	COG0398	Pfam SNARE associated Golgi protein
BJG88_RS10055	COG0166	Belongs to the GPI family
BJG88_RS10060	COG0137	argininosuccinate synthase activity
BJG88_RS10065	COG0165	Argininosuccinate lyase
BJG88_RS10070	COG0584	glycerophosphoryl diester phosphodiesterase
BJG88_RS10080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BJG88_RS10085	COG1902	pentaerythritol trinitrate reductase activity
BJG88_RS10090	COG1098	S1 RNA binding domain
BJG88_RS10095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BJG88_RS10105	COG2111	Na H antiporter
BJG88_RS10105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BJG88_RS10110	COG2111	Na H antiporter
BJG88_RS10115	COG1006	Multisubunit Na H antiporter MnhC subunit
BJG88_RS10120	COG0651	ATP synthesis coupled electron transport
BJG88_RS10125	COG1863	multisubunit Na H antiporter MnhE subunit
BJG88_RS10130	COG2212	antiporter activity
BJG88_RS10135	COG1320	monovalent cation:proton antiporter activity
BJG88_RS10145	COG2050	protein possibly involved in aromatic compounds catabolism
BJG88_RS10150	COG2056	Na+-H+ antiporter family
BJG88_RS10155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BJG88_RS10160	COG1252	NADH dehydrogenase
BJG88_RS10165	COG0316	Belongs to the HesB IscA family
BJG88_RS10170	COG4844	belongs to the
BJG88_RS10175	COG1252	NADH dehydrogenase
BJG88_RS10180	COG4837	Protein of unknown function (DUF1462)
BJG88_RS10185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BJG88_RS10190	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BJG88_RS10195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BJG88_RS10200	COG1696	Membrane protein involved in D-alanine export
BJG88_RS10205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BJG88_RS10215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BJG88_RS10220	COG0647	UMP catabolic process
BJG88_RS10225	COG2445	Protein of unknown function DUF86
BJG88_RS10235	COG4470	Protein conserved in bacteria
BJG88_RS10240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BJG88_RS10245	COG0737	Belongs to the 5'-nucleotidase family
BJG88_RS10250	COG0730	response to heat
BJG88_RS10255	COG1801	Protein of unknown function DUF72
BJG88_RS10260	COG2070	2-Nitropropane dioxygenase
BJG88_RS10265	COG1253	flavin adenine dinucleotide binding
BJG88_RS10350	COG0739	heme binding
BJG88_RS10470	COG0756	dUTP diphosphatase activity
BJG88_RS10535	COG1484	DNA-dependent DNA replication
BJG88_RS10590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BJG88_RS10600	COG4974	Belongs to the 'phage' integrase family
BJG88_RS10605	COG0719	Fe-S assembly protein
BJG88_RS10610	COG0822	iron-sulfur transferase activity
BJG88_RS10620	COG0719	Fe-S assembly protein
BJG88_RS10625	COG0396	ATPase activity
BJG88_RS10640	COG1464	Belongs to the NlpA lipoprotein family
BJG88_RS10645	COG2011	ABC-type metal ion transport system permease component
BJG88_RS10650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BJG88_RS10655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BJG88_RS10660	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BJG88_RS10665	COG0509	glycine decarboxylation via glycine cleavage system
BJG88_RS10670	COG1393	Belongs to the ArsC family
BJG88_RS10675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BJG88_RS10685	COG0710	3-dehydroquinate dehydratase activity
BJG88_RS10690	COG1764	response to oxidative stress
BJG88_RS10715	COG2314	TM2 domain
BJG88_RS10755	COG0346	lactoylglutathione lyase activity
BJG88_RS10790	COG1288	antiporter activity
BJG88_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS10810	COG0584	glycerophosphoryl diester phosphodiesterase
BJG88_RS10830	COG1051	belongs to the nudix hydrolase family
BJG88_RS10865	COG1525	nuclease
BJG88_RS10965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BJG88_RS10970	COG0557	exoribonuclease II activity
BJG88_RS10975	COG1647	Serine aminopeptidase, S33
BJG88_RS10980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BJG88_RS10990	COG0148	phosphopyruvate hydratase activity
BJG88_RS10995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BJG88_RS11000	COG0149	triose-phosphate isomerase activity
BJG88_RS11005	COG0126	phosphoglycerate kinase activity
BJG88_RS11010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BJG88_RS11035	COG1090	epimerase
BJG88_RS11040	COG0740	serine-type endopeptidase activity
BJG88_RS11055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BJG88_RS11060	COG1481	regulation of sporulation
BJG88_RS11065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BJG88_RS11070	COG1660	Displays ATPase and GTPase activities
BJG88_RS11075	COG0492	ferredoxin-NADP+ reductase activity
BJG88_RS11085	COG0110	maltose O-acetyltransferase activity
BJG88_RS11090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BJG88_RS11095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BJG88_RS11100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BJG88_RS11105	COG0556	nucleotide-excision repair
BJG88_RS11120	COG3942	CHAP domain
BJG88_RS11120	COG1388	LysM domain
BJG88_RS11130	COG0653	protein targeting
BJG88_RS11135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BJG88_RS11140	COG1040	competence protein
BJG88_RS11145	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BJG88_RS11155	COG1739	Uncharacterized protein family UPF0029
BJG88_RS11160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BJG88_RS11165	COG2199	diguanylate cyclase activity
BJG88_RS11180	COG2195	Cleaves the N-terminal amino acid of tripeptides
BJG88_RS11185	COG1929	Belongs to the glycerate kinase type-1 family
BJG88_RS11205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BJG88_RS11220	COG4607	ABC-type enterochelin transport system periplasmic component
BJG88_RS11225	COG4604	ABC transporter, ATP-binding protein
BJG88_RS11230	COG4605	iron ion homeostasis
BJG88_RS11235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BJG88_RS11240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BJG88_RS11245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BJG88_RS11250	COG1780	Probably involved in ribonucleotide reductase function
BJG88_RS11260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BJG88_RS11265	COG3104	oligopeptide transport
BJG88_RS11270	COG3104	oligopeptide transport
BJG88_RS11275	COG1597	lipid kinase activity
BJG88_RS11285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BJG88_RS11290	COG1174	glycine betaine transport
BJG88_RS11300	COG0514	ATP-dependent DNA helicase (RecQ)
BJG88_RS11305	COG0488	(ABC) transporter
BJG88_RS11315	COG1368	sulfuric ester hydrolase activity
BJG88_RS11345	COG0512	Glutamine amidotransferase of anthranilate synthase
BJG88_RS11350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BJG88_RS11355	COG0720	synthase
BJG88_RS11360	COG0602	queuosine metabolic process
BJG88_RS11375	COG0463	Glycosyl transferase, family 2
BJG88_RS11380	COG0656	L-ascorbic acid biosynthetic process
BJG88_RS11385	COG1253	flavin adenine dinucleotide binding
BJG88_RS11390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BJG88_RS11395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BJG88_RS11395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BJG88_RS11395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BJG88_RS11400	COG1105	Belongs to the carbohydrate kinase PfkB family
BJG88_RS11405	COG1349	DNA-binding transcription factor activity
BJG88_RS11410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BJG88_RS11415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BJG88_RS11445	COG0039	L-malate dehydrogenase activity
BJG88_RS11450	COG0586	Pfam SNARE associated Golgi protein
BJG88_RS11460	COG4989	oxidoreductase activity
BJG88_RS11475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BJG88_RS11480	COG4988	ABC transporter
BJG88_RS11485	COG1968	undecaprenyl-diphosphatase activity
BJG88_RS11495	COG1671	Belongs to the UPF0178 family
BJG88_RS11500	COG1611	Belongs to the LOG family
BJG88_RS11505	COG1279	arginine transmembrane transporter activity
BJG88_RS11510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BJG88_RS11540	COG2814	Major facilitator Superfamily
BJG88_RS11545	COG2839	Protein conserved in bacteria
BJG88_RS11550	COG2814	Major facilitator Superfamily
BJG88_RS11555	COG0583	DNA-binding transcription factor activity
BJG88_RS11565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BJG88_RS11575	COG0217	transcriptional regulatory protein
BJG88_RS11585	COG1388	LysM domain
BJG88_RS11585	COG3942	CHAP domain
BJG88_RS11590	COG0306	phosphate transporter
BJG88_RS11595	COG1392	Phosphate transport regulator
BJG88_RS11600	COG2205	protein histidine kinase activity
BJG88_RS11605	COG0745	RESPONSE REGULATOR receiver
BJG88_RS11610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BJG88_RS11625	COG4555	ABC transporter
BJG88_RS11645	COG3949	Membrane
BJG88_RS11655	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BJG88_RS11665	COG2376	Dihydroxyacetone kinase
BJG88_RS11670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BJG88_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BJG88_RS11680	COG1120	ATPase activity
BJG88_RS11685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BJG88_RS11690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BJG88_RS11695	COG1132	(ABC) transporter
BJG88_RS11705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BJG88_RS11715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BJG88_RS11720	COG1682	transport, permease protein
BJG88_RS11725	COG1134	teichoic acid transport
BJG88_RS11730	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BJG88_RS11740	COG1321	iron dependent repressor
BJG88_RS11750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BJG88_RS11755	COG0803	Belongs to the bacterial solute-binding protein 9 family
BJG88_RS11765	COG1320	monovalent cation:proton antiporter activity
BJG88_RS11770	COG2212	antiporter activity
BJG88_RS11775	COG1863	multisubunit Na H antiporter MnhE subunit
BJG88_RS11780	COG0651	ATP synthesis coupled electron transport
BJG88_RS11785	COG1006	Multisubunit Na H antiporter MnhC subunit
BJG88_RS11790	COG2111	Na H antiporter
BJG88_RS11795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BJG88_RS11795	COG2111	Na H antiporter
BJG88_RS11800	COG4974	Belongs to the 'phage' integrase family
BJG88_RS11835	COG0596	Alpha beta hydrolase
BJG88_RS11850	COG2267	carboxylic ester hydrolase activity
BJG88_RS11855	COG0546	phosphoglycolate phosphatase activity
BJG88_RS11860	COG4139	cobalamin transport
BJG88_RS11865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BJG88_RS11870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BJG88_RS11875	COG0018	arginyl-trna synthetase
BJG88_RS11890	COG1078	dGTPase activity
BJG88_RS11895	COG0456	acetyltransferase
BJG88_RS11900	COG0655	NAD(P)H dehydrogenase (quinone) activity
BJG88_RS11905	COG0667	Aldo Keto reductase
BJG88_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS11925	COG4844	belongs to the
BJG88_RS11930	COG1082	Xylose isomerase domain protein TIM barrel
BJG88_RS11935	COG0673	inositol 2-dehydrogenase activity
BJG88_RS11945	COG0673	inositol 2-dehydrogenase activity
BJG88_RS11955	COG1263	PTS System
BJG88_RS11955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS11975	COG0095	Lipoate-protein ligase
BJG88_RS11980	COG0280	phosphate acetyltransferase
BJG88_RS11985	COG3253	May function as heme-dependent peroxidase
BJG88_RS12020	COG2363	Small membrane protein
BJG88_RS12030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BJG88_RS12060	COG0183	Belongs to the thiolase family
BJG88_RS12065	COG0318	PFAM AMP-dependent synthetase and ligase
BJG88_RS12075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BJG88_RS12080	COG0363	glucosamine-6-phosphate deaminase activity
BJG88_RS12090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BJG88_RS12095	COG1469	GTP cyclohydrolase I activity
BJG88_RS12110	COG0431	NADPH-dependent FMN reductase
BJG88_RS12115	COG0561	phosphatase activity
BJG88_RS12125	COG1428	Deoxynucleoside kinase
BJG88_RS12130	COG1428	Deoxynucleoside kinase
BJG88_RS12140	COG0546	phosphoglycolate phosphatase activity
BJG88_RS12145	COG4297	protein containing double-stranded beta helix domain
BJG88_RS12150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BJG88_RS12155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BJG88_RS12165	COG0583	DNA-binding transcription factor activity
BJG88_RS12170	COG2814	Major facilitator Superfamily
BJG88_RS12185	COG0010	Belongs to the arginase family
BJG88_RS12190	COG1914	H( )-stimulated, divalent metal cation uptake system
BJG88_RS12195	COG3949	Membrane
BJG88_RS12205	COG1132	(ABC) transporter
BJG88_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS12215	COG1312	Catalyzes the dehydration of D-mannonate
BJG88_RS12220	COG1904	glucuronate isomerase
BJG88_RS12245	COG0800	Aldolase
BJG88_RS12255	COG0583	DNA-binding transcription factor activity
BJG88_RS12285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BJG88_RS12310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BJG88_RS12315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BJG88_RS12335	COG1473	amidohydrolase
BJG88_RS12340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BJG88_RS12345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BJG88_RS12350	COG0049	tRNA binding
BJG88_RS12355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BJG88_RS12365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BJG88_RS12370	COG0085	RNA polymerase activity
BJG88_RS12375	COG2813	Specifically methylates the guanine in position
BJG88_RS12380	COG0222	ribosome binding
BJG88_RS12385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BJG88_RS12395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BJG88_RS12400	COG0250	Participates in transcription elongation, termination and antitermination
BJG88_RS12405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BJG88_RS12410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BJG88_RS12425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BJG88_RS12430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BJG88_RS12435	COG0215	cysteine-tRNA ligase activity
BJG88_RS12440	COG1045	serine acetyltransferase
BJG88_RS12445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BJG88_RS12450	COG4956	integral membrane protein (PIN domain superfamily)
BJG88_RS12455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BJG88_RS12460	COG0542	response to heat
BJG88_RS12465	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BJG88_RS12470	COG3880	PFAM UvrB UvrC protein
BJG88_RS12475	COG4463	regulation of RNA biosynthetic process
BJG88_RS12480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BJG88_RS12485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BJG88_RS12490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BJG88_RS12495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BJG88_RS12580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BJG88_RS12585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BJG88_RS12605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BJG88_RS12610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BJG88_RS12625	COG1098	S1 RNA binding domain
BJG88_RS12635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BJG88_RS12640	COG3956	TIGRFAM MazG family protein
BJG88_RS12645	COG2244	polysaccharide biosynthetic process
BJG88_RS12650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BJG88_RS12655	COG0193	aminoacyl-tRNA hydrolase activity
BJG88_RS12660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BJG88_RS12665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BJG88_RS12670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BJG88_RS12675	COG2088	sporulation resulting in formation of a cellular spore
BJG88_RS12680	COG0251	oxidation-reduction process
BJG88_RS12685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BJG88_RS12690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BJG88_RS12695	COG4466	Protein conserved in bacteria
BJG88_RS12700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BJG88_RS12705	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BJG88_RS12710	COG0084	hydrolase, TatD family'
BJG88_RS12715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BJG88_RS12715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BJG88_RS12720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BJG88_RS12725	COG2827	Endonuclease containing a URI domain
BJG88_RS12730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BJG88_RS12735	COG4467	Involved in initiation control of chromosome replication
BJG88_RS12740	COG1774	PSP1 C-terminal conserved region
BJG88_RS12745	COG0470	DNA polymerase III
BJG88_RS12750	COG3870	Protein conserved in bacteria
BJG88_RS12755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BJG88_RS12760	COG1982	Orn Lys Arg decarboxylase major
BJG88_RS12780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BJG88_RS12785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BJG88_RS12790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BJG88_RS12805	COG2188	Transcriptional regulator
BJG88_RS12810	COG0366	Alpha amylase catalytic
BJG88_RS12815	COG1263	PTS System
BJG88_RS12815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BJG88_RS12825	COG0493	'glutamate synthase
BJG88_RS12830	COG0067	glutamate synthase
BJG88_RS12830	COG0069	glutamate synthase activity
BJG88_RS12830	COG0070	glutamate synthase
BJG88_RS12855	COG0753	catalase activity
BJG88_RS12865	COG1316	TRANSCRIPTIONal
BJG88_RS12875	COG0772	Belongs to the SEDS family
BJG88_RS12880	COG1051	belongs to the nudix hydrolase family
BJG88_RS12890	COG3942	CHAP domain
BJG88_RS12890	COG1388	LysM domain
BJG88_RS12900	COG0129	dihydroxy-acid dehydratase activity
BJG88_RS12910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BJG88_RS12915	COG0733	neurotransmitter:sodium symporter activity
BJG88_RS12920	COG1114	Component of the transport system for branched-chain amino acids
BJG88_RS12925	COG5646	InterPro IPR014922
BJG88_RS12930	COG1647	Serine aminopeptidase, S33
BJG88_RS12935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BJG88_RS12940	COG2807	transmembrane transport
BJG88_RS12955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BJG88_RS12960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BJG88_RS12965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BJG88_RS12970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BJG88_RS12975	COG3257	ureidoglycine aminohydrolase activity
BJG88_RS12980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BJG88_RS12990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BJG88_RS12995	COG0406	alpha-ribazole phosphatase activity
BJG88_RS13000	COG1115	amino acid carrier protein
BJG88_RS13005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BJG88_RS13010	COG1953	Uracil, thiamine, allantoin
BJG88_RS13015	COG2508	Transcriptional regulator
BJG88_RS13020	COG2814	Major facilitator Superfamily
BJG88_RS13025	COG2814	Major facilitator Superfamily
BJG88_RS13045	COG2140	Oxalate decarboxylase
BJG88_RS13050	COG0405	Gamma-glutamyltransferase
BJG88_RS13055	COG2233	PERMEase
BJG88_RS13095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BJG88_RS13095	COG0519	Catalyzes the synthesis of GMP from XMP
BJG88_RS13100	COG0517	IMP dehydrogenase activity
BJG88_RS13100	COG0516	GMP reductase activity
BJG88_RS13105	COG2233	PERMEase
BJG88_RS13110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BJG88_RS13125	COG5183	chlorophyll binding
BJG88_RS13130	COG1823	symporter activity
BJG88_RS13140	COG0778	Nitroreductase
BJG88_RS13145	COG0753	catalase activity
BJG88_RS13155	COG3279	Response regulator of the LytR AlgR family
BJG88_RS13170	COG0450	alkyl hydroperoxide reductase
BJG88_RS13175	COG3634	alkyl hydroperoxide reductase activity
BJG88_RS13190	COG0588	phosphoglycerate mutase activity
BJG88_RS13205	COG2076	Multidrug Resistance protein
BJG88_RS13210	COG2076	Multidrug Resistance protein
BJG88_RS13220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BJG88_RS13235	COG4195	phage-related replication protein
BJG88_RS13280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BJG88_RS13290	COG0360	Binds together with S18 to 16S ribosomal RNA
BJG88_RS13300	COG1695	Transcriptional regulator
BJG88_RS13305	COG3479	Phenolic acid decarboxylase
BJG88_RS13310	COG0012	GTP binding
BJG88_RS13315	COG4481	Protein conserved in bacteria
BJG88_RS13320	COG0668	transmembrane transport
BJG88_RS13325	COG5609	conserved protein (DUF2294)
BJG88_RS13330	COG3002	Belongs to the UPF0753 family
BJG88_RS13335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BJG88_RS13345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BJG88_RS13355	COG2814	Major facilitator Superfamily
BJG88_RS13375	COG1388	LysM domain
BJG88_RS13400	COG1131	(ABC) transporter
BJG88_RS13440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BJG88_RS13445	COG2210	Belongs to the sulfur carrier protein TusA family
BJG88_RS13450	COG1937	Protein conserved in bacteria
BJG88_RS13455	COG0730	response to heat
BJG88_RS13465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BJG88_RS13475	COG3559	Exporter of polyketide antibiotics
BJG88_RS13480	COG1131	(ABC) transporter
BJG88_RS13510	COG0772	Belongs to the SEDS family
BJG88_RS13540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BJG88_RS13550	COG0529	Catalyzes the synthesis of activated sulfate
BJG88_RS13555	COG2046	Belongs to the sulfate adenylyltransferase family
BJG88_RS13560	COG0730	response to heat
BJG88_RS13575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BJG88_RS13580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BJG88_RS13585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BJG88_RS13590	COG0175	sulfate reduction
BJG88_RS13595	COG3620	sequence-specific DNA binding
BJG88_RS13635	COG2311	Membrane
BJG88_RS13645	COG2188	Transcriptional regulator
BJG88_RS13650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BJG88_RS13665	COG3964	amidohydrolase
BJG88_RS13670	COG1017	nitric oxide dioxygenase activity
BJG88_RS13670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BJG88_RS13680	COG1475	DNA binding
BJG88_RS13690	COG0626	cystathionine gamma-synthase activity
BJG88_RS13695	COG0626	cystathionine gamma-synthase activity
BJG88_RS13700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BJG88_RS13700	COG0646	methionine synthase
BJG88_RS13705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BJG88_RS13715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BJG88_RS13735	COG0183	Belongs to the thiolase family
BJG88_RS13740	COG1024	Enoyl-CoA hydratase
BJG88_RS13740	COG1250	3-hydroxyacyl-CoA dehydrogenase
BJG88_RS13745	COG1960	acyl-CoA dehydrogenase activity
BJG88_RS13750	COG0318	PFAM AMP-dependent synthetase and ligase
BJG88_RS13770	COG4175	Glycine betaine
BJG88_RS13770	COG3448	diguanylate cyclase activity
BJG88_RS13775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BJG88_RS13790	COG0561	phosphatase activity
BJG88_RS13795	COG1917	Cupin 2, conserved barrel domain protein
BJG88_RS13795	COG2207	Transcriptional regulator
BJG88_RS13800	COG0697	spore germination
BJG88_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
BJG88_RS13815	COG2239	Acts as a magnesium transporter
BJG88_RS13825	COG0531	amino acid
BJG88_RS13850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BJG88_RS13860	COG1285	pathogenesis
BJG88_RS13875	COG3181	Tripartite tricarboxylate transporter family receptor
BJG88_RS13880	COG2271	Major facilitator Superfamily
BJG88_RS13890	COG1966	Carbon starvation protein
BJG88_RS13895	COG1475	DNA binding
BJG88_RS13900	COG0357	Ribosomal RNA small subunit methyltransferase G
BJG88_RS13905	COG0445	tRNA wobble uridine modification
BJG88_RS13910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BJG88_RS13915	COG0594	ribonuclease P activity