locus-tag	class	description
DWB95_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB95_RS00010	COG0592	DNA-directed DNA polymerase activity
DWB95_RS00015	COG2501	S4 domain
DWB95_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB95_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWB95_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWB95_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB95_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DWB95_RS00075	COG0359	binds to the 23S rRNA
DWB95_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
DWB95_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB95_RS00100	COG0745	RESPONSE REGULATOR receiver
DWB95_RS00105	COG5002	protein histidine kinase activity
DWB95_RS00110	COG4863	YycH protein
DWB95_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWB95_RS00130	COG4195	phage-related replication protein
DWB95_RS00135	COG0702	epimerase
DWB95_RS00150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB95_RS00155	COG2819	hydrolase of the alpha beta superfamily
DWB95_RS00195	COG2814	Major facilitator Superfamily
DWB95_RS00245	COG3223	Belongs to the PsiE family
DWB95_RS00255	COG1473	amidohydrolase
DWB95_RS00335	COG2851	Citrate transporter
DWB95_RS00340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB95_RS00345	COG4591	ABC-type transport system involved in lipoprotein release permease component
DWB95_RS00350	COG1136	(ABC) transporter
DWB95_RS00350	COG0577	efflux transmembrane transporter activity
DWB95_RS00370	COG2226	methyltransferase
DWB95_RS00400	COG0110	maltose O-acetyltransferase activity
DWB95_RS00405	COG1114	Component of the transport system for branched-chain amino acids
DWB95_RS00410	COG2814	Major facilitator Superfamily
DWB95_RS00415	COG1335	isochorismatase
DWB95_RS00445	COG1869	D-ribose catabolic process
DWB95_RS00460	COG0604	alcohol dehydrogenase
DWB95_RS00475	COG1131	(ABC) transporter
DWB95_RS00505	COG0601	transmembrane transport
DWB95_RS00515	COG0444	Belongs to the ABC transporter superfamily
DWB95_RS00520	COG1124	(ABC) transporter
DWB95_RS00530	COG1418	mRNA catabolic process
DWB95_RS00545	COG0405	Gamma-glutamyltransferase
DWB95_RS00555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB95_RS00560	COG0601	transmembrane transport
DWB95_RS00570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB95_RS00590	COG2235	arginine
DWB95_RS00595	COG1438	arginine binding
DWB95_RS00605	COG0438	transferase activity, transferring glycosyl groups
DWB95_RS00610	COG0653	protein targeting
DWB95_RS00620	COG1073	alpha beta
DWB95_RS00630	COG0201	protein transport
DWB95_RS00650	COG1686	Belongs to the peptidase S11 family
DWB95_RS00655	COG2910	NAD(P)H-binding
DWB95_RS00660	COG1876	peptidase activity
DWB95_RS00665	COG1882	Formate acetyltransferase
DWB95_RS00670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWB95_RS00680	COG3976	FMN-binding domain protein
DWB95_RS00680	COG1053	succinate dehydrogenase
DWB95_RS00680	COG0431	NADPH-dependent FMN reductase
DWB95_RS00690	COG1288	antiporter activity
DWB95_RS00715	COG1131	(ABC) transporter
DWB95_RS00795	COG1136	(ABC) transporter
DWB95_RS00805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWB95_RS00810	COG4221	oxidoreductase activity
DWB95_RS00815	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB95_RS00820	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DWB95_RS00825	COG2962	Rard protein
DWB95_RS00830	COG0471	metal ion transport
DWB95_RS00845	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWB95_RS00850	COG3711	transcriptional antiterminator
DWB95_RS00855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB95_RS00890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB95_RS00905	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DWB95_RS00910	COG1054	Belongs to the UPF0176 family
DWB95_RS00945	COG1288	antiporter activity
DWB95_RS00970	COG2814	Major facilitator Superfamily
DWB95_RS01000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB95_RS01070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB95_RS01080	COG1309	transcriptional regulator
DWB95_RS01090	COG2113	Glycine betaine
DWB95_RS01095	COG2409	Drug exporters of the RND superfamily
DWB95_RS01100	COG1764	response to oxidative stress
DWB95_RS01110	COG3942	CHAP domain
DWB95_RS01110	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB95_RS01125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB95_RS01135	COG3227	Zinc metalloprotease (Elastase)
DWB95_RS01150	COG3961	Belongs to the TPP enzyme family
DWB95_RS01165	COG1785	Belongs to the alkaline phosphatase family
DWB95_RS01170	COG0745	RESPONSE REGULATOR receiver
DWB95_RS01175	COG2205	protein histidine kinase activity
DWB95_RS01180	COG1136	(ABC) transporter
DWB95_RS01185	COG0577	efflux transmembrane transporter activity
DWB95_RS01210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB95_RS01225	COG3942	CHAP domain
DWB95_RS01230	COG1328	CTP reductase activity
DWB95_RS01235	COG0602	queuosine metabolic process
DWB95_RS01240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DWB95_RS01250	COG1510	regulation of RNA biosynthetic process
DWB95_RS01255	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS01260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB95_RS01265	COG1473	amidohydrolase
DWB95_RS01280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB95_RS01285	COG0574	Belongs to the PEP-utilizing enzyme family
DWB95_RS01285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB95_RS01290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB95_RS01295	COG0579	oxidoreductase
DWB95_RS01300	COG2723	6-phospho-beta-galactosidase activity
DWB95_RS01310	COG0583	DNA-binding transcription factor activity
DWB95_RS01325	COG3588	fructose-bisphosphate aldolase
DWB95_RS01330	COG0563	adenylate kinase activity
DWB95_RS01340	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB95_RS01365	COG0531	amino acid
DWB95_RS01375	COG0583	DNA-binding transcription factor activity
DWB95_RS01380	COG0039	L-malate dehydrogenase activity
DWB95_RS01385	COG0028	Belongs to the TPP enzyme family
DWB95_RS01390	COG3527	Alpha-acetolactate decarboxylase
DWB95_RS01400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWB95_RS01405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB95_RS01455	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB95_RS01465	COG0167	dihydroorotate dehydrogenase activity
DWB95_RS01470	COG3001	Fructosamine kinase
DWB95_RS01525	COG1113	amino acid transport
DWB95_RS01530	COG3189	MarR family transcriptional regulator
DWB95_RS01545	COG0741	lytic transglycosylase activity
DWB95_RS01565	COG1562	ergosterol biosynthetic process
DWB95_RS01575	COG0436	Aminotransferase
DWB95_RS01585	COG2608	mercury ion transmembrane transporter activity
DWB95_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS01610	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS01625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB95_RS01630	COG3425	synthase
DWB95_RS01650	COG0583	DNA-binding transcription factor activity
DWB95_RS01655	COG1380	Effector of murein hydrolase LrgA
DWB95_RS01660	COG1346	cytolysis
DWB95_RS01665	COG0028	Belongs to the TPP enzyme family
DWB95_RS01685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB95_RS01690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB95_RS01705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB95_RS01715	COG2843	Capsule synthesis protein
DWB95_RS01740	COG1070	Carbohydrate kinase
DWB95_RS01750	COG1760	l-serine dehydratase
DWB95_RS01755	COG1760	l-serine dehydratase
DWB95_RS01770	COG3764	Sortase (surface protein transpeptidase)
DWB95_RS01780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB95_RS01785	COG0778	Nitroreductase
DWB95_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS01795	COG2514	catechol 2,3-dioxygenase activity
DWB95_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS01810	COG3949	Membrane
DWB95_RS01825	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DWB95_RS01830	COG0586	Pfam SNARE associated Golgi protein
DWB95_RS01835	COG2271	Major facilitator Superfamily
DWB95_RS01850	COG4876	unkown
DWB95_RS01855	COG2357	RelA SpoT domain protein
DWB95_RS01870	COG1070	Carbohydrate kinase
DWB95_RS01875	COG2610	gluconate transmembrane transporter activity
DWB95_RS01880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB95_RS01890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB95_RS01895	COG0438	transferase activity, transferring glycosyl groups
DWB95_RS01900	COG0494	nUDIX hydrolase
DWB95_RS01940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB95_RS01950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWB95_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS01960	COG1363	Peptidase, m42
DWB95_RS01965	COG4808	Protein conserved in bacteria
DWB95_RS01980	COG0069	glutamate synthase activity
DWB95_RS01995	COG2205	protein histidine kinase activity
DWB95_RS02000	COG0745	RESPONSE REGULATOR receiver
DWB95_RS02005	COG2814	Major facilitator Superfamily
DWB95_RS02010	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB95_RS02015	COG0531	amino acid
DWB95_RS02020	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DWB95_RS02045	COG1174	glycine betaine transport
DWB95_RS02050	COG1346	cytolysis
DWB95_RS02055	COG1380	Effector of murein hydrolase LrgA
DWB95_RS02065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB95_RS02080	COG0706	membrane insertase activity
DWB95_RS02085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB95_RS02090	COG0531	amino acid
DWB95_RS02100	COG1113	amino acid transport
DWB95_RS02105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWB95_RS02120	COG2814	Major facilitator Superfamily
DWB95_RS02130	COG1929	Belongs to the glycerate kinase type-1 family
DWB95_RS02145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWB95_RS02150	COG0741	lytic transglycosylase activity
DWB95_RS02155	COG0588	phosphoglycerate mutase activity
DWB95_RS02165	COG2814	Major facilitator Superfamily
DWB95_RS02170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB95_RS02175	COG0765	amino acid transport
DWB95_RS02180	COG1126	abc transporter atp-binding protein
DWB95_RS02200	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB95_RS02220	COG0454	-acetyltransferase
DWB95_RS02230	COG0747	negative chemotaxis
DWB95_RS02240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB95_RS02245	COG2146	nitrite reductase [NAD(P)H] activity
DWB95_RS02255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB95_RS02260	COG1140	nitrate reductase beta subunit
DWB95_RS02270	COG2181	nitrate reductase activity
DWB95_RS02280	COG4585	Histidine kinase
DWB95_RS02290	COG2223	nitrite transmembrane transporter activity
DWB95_RS02305	COG0778	Nitroreductase
DWB95_RS02340	COG1263	PTS System
DWB95_RS02340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB95_RS02350	COG1309	transcriptional regulator
DWB95_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS02365	COG0583	DNA-binding transcription factor activity
DWB95_RS02370	COG2610	gluconate transmembrane transporter activity
DWB95_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS02410	COG0492	ferredoxin-NADP+ reductase activity
DWB95_RS02415	COG0456	acetyltransferase
DWB95_RS02420	COG0604	alcohol dehydrogenase
DWB95_RS02425	COG2822	iron ion transport
DWB95_RS02430	COG2837	iron assimilation
DWB95_RS02435	COG0672	)-iron permease
DWB95_RS02440	COG0805	protein transport
DWB95_RS02445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB95_RS02455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB95_RS02455	COG0463	Glycosyl transferase, family 2
DWB95_RS02465	COG0463	Glycosyl transferase, family 2
DWB95_RS02465	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB95_RS02470	COG1620	l-lactate permease
DWB95_RS02475	COG0297	glycogen (starch) synthase activity
DWB95_RS02480	COG0579	oxidoreductase
DWB95_RS02505	COG0577	efflux transmembrane transporter activity
DWB95_RS02525	COG4640	response to antibiotic
DWB95_RS02530	COG2814	Major facilitator Superfamily
DWB95_RS02540	COG1566	PFAM secretion protein HlyD family protein
DWB95_RS02545	COG2814	Major facilitator Superfamily
DWB95_RS02570	COG0598	Magnesium transport protein CorA
DWB95_RS02575	COG1304	FMN binding
DWB95_RS02580	COG0786	glutamate:sodium symporter activity
DWB95_RS02585	COG1695	Transcriptional regulator
DWB95_RS02600	COG2094	Belongs to the DNA glycosylase MPG family
DWB95_RS02610	COG1396	sequence-specific DNA binding
DWB95_RS02620	COG1069	ribulokinase activity
DWB95_RS02625	COG4152	abc transporter atp-binding protein
DWB95_RS02630	COG1668	transmembrane transport
DWB95_RS02635	COG1742	UPF0060 membrane protein
DWB95_RS02640	COG2017	converts alpha-aldose to the beta-anomer
DWB95_RS02645	COG2258	MOSC domain
DWB95_RS02650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB95_RS02660	COG1266	CAAX protease self-immunity
DWB95_RS02665	COG0010	Belongs to the arginase family
DWB95_RS02670	COG0583	DNA-binding transcription factor activity
DWB95_RS02690	COG1473	amidohydrolase
DWB95_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS02715	COG1737	Transcriptional regulator
DWB95_RS02720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB95_RS02720	COG1263	PTS System
DWB95_RS02730	COG0385	Bile acid
DWB95_RS02735	COG0546	phosphoglycolate phosphatase activity
DWB95_RS02755	COG1113	amino acid transport
DWB95_RS02760	COG1737	Transcriptional regulator
DWB95_RS02765	COG1263	PTS System
DWB95_RS02765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB95_RS02770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB95_RS02795	COG1316	TRANSCRIPTIONal
DWB95_RS02825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB95_RS02830	COG2076	Multidrug Resistance protein
DWB95_RS02835	COG2076	Multidrug Resistance protein
DWB95_RS02840	COG3942	CHAP domain
DWB95_RS02855	COG1757	Na H antiporter
DWB95_RS02860	COG3942	CHAP domain
DWB95_RS02870	COG1846	Transcriptional regulator
DWB95_RS02885	COG0829	nickel cation binding
DWB95_RS02895	COG0830	nickel cation binding
DWB95_RS02900	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DWB95_RS02905	COG0804	urea catabolic process
DWB95_RS02915	COG0831	urea catabolic process
DWB95_RS02920	COG4413	Urea transporter
DWB95_RS02925	COG0765	amino acid transport
DWB95_RS02930	COG0765	amino acid transport
DWB95_RS02935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB95_RS02940	COG1126	abc transporter atp-binding protein
DWB95_RS02945	COG1960	acyl-CoA dehydrogenase activity
DWB95_RS02950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB95_RS02955	COG1957	nucleoside hydrolase
DWB95_RS02960	COG1268	BioY protein
DWB95_RS02970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWB95_RS02975	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWB95_RS02980	COG4149	molybdate abc transporter
DWB95_RS02985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DWB95_RS02990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB95_RS03000	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB95_RS03030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB95_RS03040	COG2814	Major facilitator Superfamily
DWB95_RS03060	COG2348	transferase activity, transferring amino-acyl groups
DWB95_RS03065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB95_RS03085	COG4975	Glucose uptake
DWB95_RS03095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB95_RS03095	COG0551	DNA topoisomerase type I activity
DWB95_RS03100	COG2252	PERMEase
DWB95_RS03115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB95_RS03120	COG0088	Forms part of the polypeptide exit tunnel
DWB95_RS03125	COG0089	rRNA binding
DWB95_RS03130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB95_RS03135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB95_RS03140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWB95_RS03145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWB95_RS03150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWB95_RS03160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWB95_RS03165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB95_RS03170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB95_RS03180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB95_RS03185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB95_RS03190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWB95_RS03195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWB95_RS03200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB95_RS03205	COG1841	ribosomal large subunit assembly
DWB95_RS03215	COG0201	protein transport
DWB95_RS03220	COG0563	adenylate kinase activity
DWB95_RS03225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWB95_RS03235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWB95_RS03240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB95_RS03245	COG0202	RNA polymerase activity
DWB95_RS03250	COG0203	ribosomal protein L17
DWB95_RS03260	COG1122	ATPase activity
DWB95_RS03270	COG0101	tRNA pseudouridine synthase activity
DWB95_RS03275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWB95_RS03285	COG0789	Transcriptional regulator
DWB95_RS03300	COG0698	ribose 5-phosphate isomerase
DWB95_RS03340	COG2130	NADP-dependent
DWB95_RS03345	COG0604	alcohol dehydrogenase
DWB95_RS03360	COG1302	Protein conserved in bacteria
DWB95_RS03365	COG4264	IucA IucC family
DWB95_RS03370	COG2814	Major facilitator Superfamily
DWB95_RS03375	COG4264	IucA IucC family
DWB95_RS03380	COG3457	Alanine racemase
DWB95_RS03385	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB95_RS03390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS03395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS03400	COG3314	Sporulation integral membrane protein YlbJ
DWB95_RS03405	COG2329	Antibiotic biosynthesis monooxygenase
DWB95_RS03415	COG1988	membrane-bound metal-dependent
DWB95_RS03420	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DWB95_RS03425	COG1272	protein, Hemolysin III
DWB95_RS03440	COG2814	Major facilitator Superfamily
DWB95_RS03445	COG0489	protein tyrosine kinase activity
DWB95_RS03500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DWB95_RS03540	COG0561	phosphatase activity
DWB95_RS03560	COG0640	Transcriptional regulator
DWB95_RS03565	COG0702	epimerase
DWB95_RS03570	COG1482	cell wall glycoprotein biosynthetic process
DWB95_RS03590	COG0783	Belongs to the Dps family
DWB95_RS03595	COG0813	purine-nucleoside phosphorylase activity
DWB95_RS03600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWB95_RS03605	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DWB95_RS03610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DWB95_RS03620	COG1854	S-ribosylhomocysteine lyase activity
DWB95_RS03640	COG5146	pantothenate kinase activity
DWB95_RS03655	COG0504	CTP synthase activity
DWB95_RS03665	COG0191	fructose-bisphosphate aldolase activity
DWB95_RS03670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB95_RS03680	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS03685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWB95_RS03690	COG0254	rRNA binding
DWB95_RS03700	COG1435	thymidine kinase activity
DWB95_RS03705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWB95_RS03710	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB95_RS03715	COG0009	L-threonylcarbamoyladenylate synthase
DWB95_RS03720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB95_RS03725	COG4475	Protein of unknown function (DUF436)
DWB95_RS03735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB95_RS03740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB95_RS03765	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB95_RS03785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWB95_RS03795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB95_RS03800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB95_RS03810	COG0629	single-stranded DNA binding
DWB95_RS03820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DWB95_RS03830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWB95_RS03835	COG0352	thiamine-phosphate diphosphorylase activity
DWB95_RS03840	COG0706	membrane insertase activity
DWB95_RS03845	COG1418	mRNA catabolic process
DWB95_RS03850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB95_RS03855	COG1937	Protein conserved in bacteria
DWB95_RS03870	COG0772	Belongs to the SEDS family
DWB95_RS03875	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB95_RS03880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB95_RS03885	COG0513	Belongs to the DEAD box helicase family
DWB95_RS03895	COG3428	Bacterial PH domain
DWB95_RS03900	COG3402	PFAM membrane-flanked domain
DWB95_RS03905	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB95_RS03910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWB95_RS03920	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB95_RS03925	COG2208	phosphoserine phosphatase activity
DWB95_RS03940	COG1191	sigma factor activity
DWB95_RS03945	COG2183	response to ionizing radiation
DWB95_RS03950	COG3091	SprT-like family
DWB95_RS03990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWB95_RS03995	COG0473	3-isopropylmalate dehydrogenase activity
DWB95_RS04000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB95_RS04015	COG0028	Belongs to the TPP enzyme family
DWB95_RS04020	COG0129	dihydroxy-acid dehydratase activity
DWB95_RS04025	COG0802	atpase or kinase
DWB95_RS04030	COG1214	PFAM Peptidase M22, glycoprotease
DWB95_RS04035	COG0456	acetyltransferase
DWB95_RS04040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB95_RS04045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DWB95_RS04050	COG0488	(ABC) transporter
DWB95_RS04055	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DWB95_RS04065	COG2391	methyltransferase activity
DWB95_RS04070	COG0425	Belongs to the sulfur carrier protein TusA family
DWB95_RS04080	COG1609	Transcriptional regulator
DWB95_RS04085	COG1621	beta-fructofuranosidase activity
DWB95_RS04090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB95_RS04100	COG3290	protein histidine kinase activity
DWB95_RS04145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB95_RS04150	COG0459	protein refolding
DWB95_RS04165	COG0436	Aminotransferase
DWB95_RS04175	COG1725	Transcriptional regulator
DWB95_RS04180	COG1131	(ABC) transporter
DWB95_RS04190	COG1131	(ABC) transporter
DWB95_RS04240	COG4974	Belongs to the 'phage' integrase family
DWB95_RS04270	COG3682	Transcriptional regulator
DWB95_RS04280	COG2706	6-phosphogluconolactonase activity
DWB95_RS04285	COG1012	belongs to the aldehyde dehydrogenase family
DWB95_RS04290	COG1227	inorganic diphosphatase activity
DWB95_RS04295	COG1335	isochorismatase
DWB95_RS04305	COG0077	Prephenate dehydratase
DWB95_RS04315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWB95_RS04320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB95_RS04325	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DWB95_RS04335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DWB95_RS04340	COG4496	protein, YerC YecD
DWB95_RS04350	COG0210	DNA helicase
DWB95_RS04355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB95_RS04365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB95_RS04380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB95_RS04390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB95_RS04400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB95_RS04410	COG1528	Iron-storage protein
DWB95_RS04425	COG4129	membrane
DWB95_RS04430	COG0024	Methionine aminopeptidase
DWB95_RS04450	COG2197	response regulator
DWB95_RS04455	COG1295	ribonuclease BN
DWB95_RS04470	COG4840	Belongs to the UPF0435 family
DWB95_RS04475	COG2309	aminopeptidase activity
DWB95_RS04480	COG1607	acyl-coa hydrolase
DWB95_RS04485	COG0535	radical SAM domain protein
DWB95_RS04500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB95_RS04515	COG1134	teichoic acid transport
DWB95_RS04515	COG1388	LysM domain
DWB95_RS04525	COG1988	membrane-bound metal-dependent
DWB95_RS04530	COG1194	a g-specific adenine glycosylase
DWB95_RS04535	COG3557	Belongs to the UPF0374 family
DWB95_RS04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB95_RS04555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB95_RS04560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB95_RS04565	COG0735	belongs to the Fur family
DWB95_RS04730	COG0765	amino acid transport
DWB95_RS04735	COG1126	abc transporter atp-binding protein
DWB95_RS04740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB95_RS04750	COG0363	glucosamine-6-phosphate deaminase activity
DWB95_RS04765	COG0114	fumarate hydratase activity
DWB95_RS04770	COG0564	pseudouridine synthase activity
DWB95_RS04775	COG2203	Gaf domain
DWB95_RS04775	COG4585	Histidine kinase
DWB95_RS04780	COG2197	response regulator
DWB95_RS04790	COG4399	Belongs to the UPF0754 family
DWB95_RS04795	COG3679	Belongs to the UPF0342 family
DWB95_RS04800	COG0420	3'-5' exonuclease activity
DWB95_RS04810	COG3481	metal-dependent phosphohydrolase, HD sub domain
DWB95_RS04820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB95_RS04835	COG0537	adenosine 5'-monophosphoramidase activity
DWB95_RS04840	COG1131	(ABC) transporter
DWB95_RS04845	COG4473	ABC transporter
DWB95_RS04850	COG2329	Antibiotic biosynthesis monooxygenase
DWB95_RS04860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB95_RS04865	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB95_RS04870	COG3545	Serine hydrolase
DWB95_RS04925	COG0318	PFAM AMP-dependent synthetase and ligase
DWB95_RS04945	COG1506	peptidase
DWB95_RS04955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB95_RS04965	COG0656	L-ascorbic acid biosynthetic process
DWB95_RS04970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB95_RS04975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB95_RS04985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB95_RS05000	COG1595	DNA-templated transcription, initiation
DWB95_RS05010	COG4193	domain, Protein
DWB95_RS05010	COG3266	domain, Protein
DWB95_RS05010	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB95_RS05020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB95_RS05020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB95_RS05025	COG0307	riboflavin synthase, alpha
DWB95_RS05030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB95_RS05030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB95_RS05035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB95_RS05040	COG0506	proline dehydrogenase activity
DWB95_RS05045	COG2267	carboxylic ester hydrolase activity
DWB95_RS05055	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DWB95_RS05060	COG1242	4 iron, 4 sulfur cluster binding
DWB95_RS05065	COG2814	Major facilitator Superfamily
DWB95_RS05070	COG0495	leucyl-tRNA aminoacylation
DWB95_RS05075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB95_RS05090	COG2081	HI0933 family
DWB95_RS05095	COG2244	polysaccharide biosynthetic process
DWB95_RS05100	COG1187	pseudouridine synthase activity
DWB95_RS05110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB95_RS05115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB95_RS05120	COG0510	thiamine kinase activity
DWB95_RS05125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB95_RS05130	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DWB95_RS05135	COG2226	methyltransferase
DWB95_RS05140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB95_RS05150	COG1363	Peptidase, m42
DWB95_RS05155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB95_RS05160	COG4848	Belongs to the UPF0354 family
DWB95_RS05165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB95_RS05170	COG1674	ftsk spoiiie
DWB95_RS05175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB95_RS05190	COG1605	Chorismate mutase
DWB95_RS05190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DWB95_RS05195	COG1609	Transcriptional regulator
DWB95_RS05205	COG0454	-acetyltransferase
DWB95_RS05210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB95_RS05220	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DWB95_RS05225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWB95_RS05235	COG0477	Major facilitator Superfamily
DWB95_RS05240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB95_RS05245	COG0204	Acyl-transferase
DWB95_RS05255	COG1263	PTS System
DWB95_RS05255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB95_RS05265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB95_RS05270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWB95_RS05275	COG1764	response to oxidative stress
DWB95_RS05280	COG0584	glycerophosphoryl diester phosphodiesterase
DWB95_RS05285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB95_RS05295	COG1956	GAF domain-containing protein
DWB95_RS05300	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DWB95_RS05305	COG1104	cysteine desulfurase activity
DWB95_RS05310	COG0301	tRNA thio-modification
DWB95_RS05325	COG0827	DNA restriction-modification system
DWB95_RS05330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB95_RS05335	COG0589	response to stress
DWB95_RS05340	COG0686	Belongs to the AlaDH PNT family
DWB95_RS05345	COG0006	proline dipeptidase activity
DWB95_RS05350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWB95_RS05360	COG4109	DRTGG domain
DWB95_RS05365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DWB95_RS05370	COG0587	DNA-directed DNA polymerase activity
DWB95_RS05375	COG0281	malic enzyme
DWB95_RS05380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB95_RS05390	COG0205	6-phosphofructokinase activity
DWB95_RS05395	COG0469	pyruvate kinase activity
DWB95_RS05400	COG1113	amino acid transport
DWB95_RS05405	COG0372	Belongs to the citrate synthase family
DWB95_RS05410	COG0538	isocitrate dehydrogenase activity
DWB95_RS05415	COG0745	RESPONSE REGULATOR receiver
DWB95_RS05420	COG5002	protein histidine kinase activity
DWB95_RS05425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB95_RS05425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB95_RS05430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB95_RS05440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB95_RS05445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB95_RS05450	COG3611	Membrane attachment protein
DWB95_RS05455	COG1484	DNA-dependent DNA replication
DWB95_RS05460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB95_RS05465	COG0833	amino acid
DWB95_RS05470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB95_RS05475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB95_RS05480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWB95_RS05485	COG4112	unkown
DWB95_RS05495	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB95_RS05500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWB95_RS05510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB95_RS05515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB95_RS05520	COG0181	hydroxymethylbilane synthase activity
DWB95_RS05530	COG0113	porphobilinogen synthase activity
DWB95_RS05535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB95_RS05540	COG3180	Ammonia monooxygenase
DWB95_RS05545	COG2818	Glycosylase
DWB95_RS05550	COG0525	valine-tRNA ligase activity
DWB95_RS05555	COG0285	dihydrofolate synthase activity
DWB95_RS05565	COG2003	Belongs to the UPF0758 family
DWB95_RS05595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB95_RS05600	COG2868	ribosomal protein
DWB95_RS05605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB95_RS05610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWB95_RS05615	COG4492	Belongs to the UPF0735 family
DWB95_RS05620	COG0632	four-way junction helicase activity
DWB95_RS05630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DWB95_RS05640	COG1862	Preprotein translocase
DWB95_RS05645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB95_RS05645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB95_RS05650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DWB95_RS05650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DWB95_RS05660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB95_RS05670	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB95_RS05680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB95_RS05690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB95_RS05695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB95_RS05700	COG1959	2 iron, 2 sulfur cluster binding
DWB95_RS05710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB95_RS05715	COG1104	cysteine desulfurase activity
DWB95_RS05720	COG0482	sulfurtransferase activity
DWB95_RS05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB95_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWB95_RS05740	COG4472	Bacterial protein of unknown function (DUF965)
DWB95_RS05745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB95_RS05750	COG3906	Belongs to the UPF0473 family
DWB95_RS05755	COG4122	O-methyltransferase activity
DWB95_RS05760	COG0826	peptidase U32
DWB95_RS05765	COG0826	peptidase U32
DWB95_RS05770	COG0572	uridine kinase
DWB95_RS05775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB95_RS05780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB95_RS05785	COG1984	allophanate hydrolase subunit 2
DWB95_RS05790	COG0511	ligase activity, forming carbon-carbon bonds
DWB95_RS05795	COG0439	Biotin carboxylase
DWB95_RS05805	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB95_RS05810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB95_RS05815	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DWB95_RS05820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DWB95_RS05825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWB95_RS05830	COG1534	Rna-binding protein
DWB95_RS05835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWB95_RS05840	COG1713	HD superfamily hydrolase involved in NAD metabolism
DWB95_RS05845	COG0799	negative regulation of ribosome biogenesis
DWB95_RS05850	COG2226	methyltransferase
DWB95_RS05855	COG2183	response to ionizing radiation
DWB95_RS05860	COG2131	deaminase
DWB95_RS05870	COG1466	dna polymerase III delta subunit
DWB95_RS05875	COG0268	Binds directly to 16S ribosomal RNA
DWB95_RS05880	COG0481	GTPase activity
DWB95_RS05885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB95_RS05895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB95_RS05900	COG0443	Heat shock 70 kDa protein
DWB95_RS05905	COG0484	heat shock protein binding
DWB95_RS05915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB95_RS05920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB95_RS05930	COG1030	water channel activity
DWB95_RS05935	COG4864	UPF0365 protein
DWB95_RS05945	COG1702	phosphate starvation-inducible protein PhoH
DWB95_RS05955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DWB95_RS05965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB95_RS05970	COG1381	Involved in DNA repair and RecF pathway recombination
DWB95_RS05975	COG0423	glycine-tRNA ligase activity
DWB95_RS05980	COG0517	IMP dehydrogenase activity
DWB95_RS05985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB95_RS05995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB95_RS06000	COG2384	SAM-dependent methyltransferase
DWB95_RS06005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB95_RS06010	COG0513	Belongs to the DEAD box helicase family
DWB95_RS06015	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWB95_RS06020	COG1121	(ABC) transporter
DWB95_RS06025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB95_RS06040	COG0768	penicillin binding
DWB95_RS06045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB95_RS06050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB95_RS06060	COG4483	Protein conserved in bacteria
DWB95_RS06065	COG1940	carbohydrate kinase activity
DWB95_RS06070	COG0011	TIGRFAM Protein of
DWB95_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB95_RS06080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB95_RS06085	COG1459	type II secretion system
DWB95_RS06090	COG4537	Required for transformation and DNA binding
DWB95_RS06105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB95_RS06110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB95_RS06125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB95_RS06130	COG0095	Lipoate-protein ligase
DWB95_RS06145	COG0006	proline dipeptidase activity
DWB95_RS06150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB95_RS06160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWB95_RS06165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWB95_RS06175	COG0511	ligase activity, forming carbon-carbon bonds
DWB95_RS06180	COG0439	Biotin carboxylase
DWB95_RS06185	COG1302	Protein conserved in bacteria
DWB95_RS06190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB95_RS06200	COG1722	exodeoxyribonuclease VII activity
DWB95_RS06210	COG1438	arginine binding
DWB95_RS06215	COG0497	DNA recombination
DWB95_RS06220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB95_RS06225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DWB95_RS06230	COG0022	dehydrogenase e1 component
DWB95_RS06235	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB95_RS06245	COG4129	membrane
DWB95_RS06250	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB95_RS06255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWB95_RS06260	COG0366	Alpha amylase catalytic
DWB95_RS06270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DWB95_RS06280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB95_RS06285	COG0300	oxidoreductase activity
DWB95_RS06290	COG0667	Aldo Keto reductase
DWB95_RS06295	COG0494	nUDIX hydrolase
DWB95_RS06300	COG0735	belongs to the Fur family
DWB95_RS06305	COG4974	Belongs to the 'phage' integrase family
DWB95_RS06320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB95_RS06325	COG1187	pseudouridine synthase activity
DWB95_RS06330	COG0745	RESPONSE REGULATOR receiver
DWB95_RS06345	COG1141	Ferredoxin
DWB95_RS06355	COG0514	ATP-dependent DNA helicase (RecQ)
DWB95_RS06365	COG0492	ferredoxin-NADP+ reductase activity
DWB95_RS06370	COG0252	asparaginase activity
DWB95_RS06375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB95_RS06380	COG0539	negative regulation of cytoplasmic translation
DWB95_RS06385	COG1160	GTP binding
DWB95_RS06390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWB95_RS06405	COG2226	methyltransferase
DWB95_RS06410	COG0142	geranyltranstransferase activity
DWB95_RS06420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB95_RS06425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB95_RS06430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWB95_RS06440	COG5582	Belongs to the UPF0302 family
DWB95_RS06445	COG4347	Protein of unknown function (DUF1405)
DWB95_RS06450	COG2738	Putative neutral zinc metallopeptidase
DWB95_RS06455	COG1694	Mazg nucleotide pyrophosphohydrolase
DWB95_RS06460	COG0438	transferase activity, transferring glycosyl groups
DWB95_RS06465	COG0617	tRNA 3'-terminal CCA addition
DWB95_RS06475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWB95_RS06475	COG1199	ATP-dependent helicase activity
DWB95_RS06480	COG0017	Asparaginyl-tRNA synthetase
DWB95_RS06485	COG3935	DnaD domain protein
DWB95_RS06490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB95_RS06500	COG4499	WXG100 protein secretion system (Wss), protein YukC
DWB95_RS06500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB95_RS06505	COG3331	DNA recombination
DWB95_RS06520	COG3599	regulation of cell shape
DWB95_RS06530	COG0116	Belongs to the methyltransferase superfamily
DWB95_RS06540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DWB95_RS06545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB95_RS06560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB95_RS06570	COG1413	lyase activity
DWB95_RS06575	COG1413	lyase activity
DWB95_RS06605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB95_RS06610	COG2190	(PTS) system
DWB95_RS06620	COG0793	Belongs to the peptidase S41A family
DWB95_RS06630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB95_RS06635	COG0671	phosphoesterase, PA-phosphatase related
DWB95_RS06640	COG1733	regulation of RNA biosynthetic process
DWB95_RS06655	COG0745	RESPONSE REGULATOR receiver
DWB95_RS06660	COG5002	protein histidine kinase activity
DWB95_RS06665	COG0567	Dehydrogenase, E1 component
DWB95_RS06675	COG1131	(ABC) transporter
DWB95_RS06700	COG0714	Associated with various cellular activities
DWB95_RS06705	COG4548	von Willebrand factor, type A
DWB95_RS06710	COG1114	Component of the transport system for branched-chain amino acids
DWB95_RS06715	COG3853	Toxic anion resistance protein (TelA)
DWB95_RS06725	COG1254	Belongs to the acylphosphatase family
DWB95_RS06735	COG1278	Cold shock
DWB95_RS06745	COG1131	(ABC) transporter
DWB95_RS06765	COG1473	amidohydrolase
DWB95_RS06775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB95_RS06780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB95_RS06785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB95_RS06790	COG0527	aspartate kinase activity
DWB95_RS06795	COG0488	(ABC) transporter
DWB95_RS06800	COG2996	Protein conserved in bacteria
DWB95_RS06805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB95_RS06810	COG0573	inorganic phosphate transmembrane transporter activity
DWB95_RS06815	COG0581	inorganic phosphate transmembrane transporter activity
DWB95_RS06820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB95_RS06825	COG0704	Plays a role in the regulation of phosphate uptake
DWB95_RS06830	COG1164	Oligoendopeptidase f
DWB95_RS06860	COG4607	ABC-type enterochelin transport system periplasmic component
DWB95_RS06865	COG0561	phosphatase activity
DWB95_RS06870	COG2348	transferase activity, transferring amino-acyl groups
DWB95_RS06875	COG2348	transferase activity, transferring amino-acyl groups
DWB95_RS06890	COG0135	phosphoribosylanthranilate isomerase activity
DWB95_RS06895	COG0134	indole-3-glycerol-phosphate synthase activity
DWB95_RS06905	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB95_RS06910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB95_RS06915	COG1363	Peptidase, m42
DWB95_RS06920	COG0287	Prephenate dehydrogenase
DWB95_RS06925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB95_RS06930	COG1942	4-Oxalocrotonate Tautomerase
DWB95_RS06945	COG0392	lysyltransferase activity
DWB95_RS06945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWB95_RS06950	COG0628	permease
DWB95_RS06955	COG3711	transcriptional antiterminator
DWB95_RS06960	COG1115	amino acid carrier protein
DWB95_RS06965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB95_RS06970	COG0187	DNA topoisomerase II activity
DWB95_RS06985	COG0824	Thioesterase
DWB95_RS06990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWB95_RS06995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB95_RS07000	COG1970	mechanosensitive ion channel activity
DWB95_RS07015	COG4846	Membrane protein involved in cytochrome C biogenesis
DWB95_RS07020	COG3763	UPF0154 protein
DWB95_RS07025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DWB95_RS07030	COG4224	UPF0291 protein
DWB95_RS07055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB95_RS07070	COG0833	amino acid
DWB95_RS07085	COG0083	homoserine kinase activity
DWB95_RS07090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB95_RS07095	COG0460	homoserine dehydrogenase
DWB95_RS07100	COG0527	aspartate kinase activity
DWB95_RS07115	COG1525	nuclease
DWB95_RS07175	COG0789	Transcriptional regulator
DWB95_RS07180	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DWB95_RS07185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB95_RS07190	COG0386	Belongs to the glutathione peroxidase family
DWB95_RS07195	COG1923	regulation of RNA biosynthetic process
DWB95_RS07200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWB95_RS07205	COG2267	carboxylic ester hydrolase activity
DWB95_RS07210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB95_RS07220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB95_RS07225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DWB95_RS07230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DWB95_RS07245	COG4550	Control of competence regulator ComK, YlbF/YmcA
DWB95_RS07250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB95_RS07260	COG4195	phage-related replication protein
DWB95_RS07265	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB95_RS07270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB95_RS07270	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB95_RS07275	COG1692	metallophosphoesterase
DWB95_RS07285	COG1418	mRNA catabolic process
DWB95_RS07290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB95_RS07295	COG1546	Belongs to the CinA family
DWB95_RS07295	COG1058	Belongs to the CinA family
DWB95_RS07305	COG1426	Protein conserved in bacteria
DWB95_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS07320	COG0612	Peptidase, M16
DWB95_RS07325	COG0612	Peptidase, M16
DWB95_RS07330	COG2188	Transcriptional regulator
DWB95_RS07335	COG1674	ftsk spoiiie
DWB95_RS07345	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB95_RS07350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWB95_RS07355	COG0196	riboflavin kinase activity
DWB95_RS07365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB95_RS07370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWB95_RS07375	COG1358	cellular component organization or biogenesis
DWB95_RS07380	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DWB95_RS07385	COG0195	Participates in both transcription termination and antitermination
DWB95_RS07390	COG0779	Required for maturation of 30S ribosomal subunits
DWB95_RS07395	COG2176	DNA-directed DNA polymerase activity
DWB95_RS07400	COG0442	prolyl-tRNA aminoacylation
DWB95_RS07415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB95_RS07420	COG0233	cytoplasmic translational termination
DWB95_RS07425	COG0528	UMP kinase activity
DWB95_RS07430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB95_RS07435	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB95_RS07455	COG4974	Belongs to the 'phage' integrase family
DWB95_RS07460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DWB95_RS07465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB95_RS07470	COG0758	DNA mediated transformation
DWB95_RS07485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DWB95_RS07490	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB95_RS07495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB95_RS07505	COG4485	Bacterial membrane protein, YfhO
DWB95_RS07520	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB95_RS07530	COG0228	four-way junction DNA binding
DWB95_RS07535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB95_RS07540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DWB95_RS07545	COG0552	protein localization to endoplasmic reticulum
DWB95_RS07550	COG1196	nuclear chromosome segregation
DWB95_RS07555	COG0571	ribonuclease III activity
DWB95_RS07575	COG0416	fatty acid biosynthetic process
DWB95_RS07580	COG1349	DNA-binding transcription factor activity
DWB95_RS07585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB95_RS07590	COG1461	Dihydroxyacetone kinase
DWB95_RS07595	COG1302	Protein conserved in bacteria
DWB95_RS07600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWB95_RS07605	COG1564	THIamine pyrophosphokinase
DWB95_RS07610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB95_RS07615	COG1162	GTPase activity
DWB95_RS07625	COG0631	protein serine/threonine phosphatase activity
DWB95_RS07630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB95_RS07635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB95_RS07635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB95_RS07640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB95_RS07655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWB95_RS07660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB95_RS07665	COG1758	RNA polymerase activity
DWB95_RS07670	COG0194	GDP metabolic process
DWB95_RS07690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB95_RS07695	COG0284	orotidine-5'-phosphate decarboxylase activity
DWB95_RS07700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB95_RS07705	COG0505	Belongs to the CarA family
DWB95_RS07710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB95_RS07715	COG0540	Belongs to the ATCase OTCase family
DWB95_RS07720	COG2233	PERMEase
DWB95_RS07725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB95_RS07730	COG0564	pseudouridine synthase activity
DWB95_RS07735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWB95_RS07740	COG3942	CHAP domain
DWB95_RS07740	COG1388	LysM domain
DWB95_RS07750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB95_RS07755	COG3599	regulation of cell shape
DWB95_RS07765	COG0762	integral membrane protein
DWB95_RS07770	COG1799	cell septum assembly
DWB95_RS07775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB95_RS07780	COG1496	oxidoreductase activity
DWB95_RS07785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB95_RS07790	COG0849	cell division
DWB95_RS07795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWB95_RS07805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB95_RS07810	COG0768	penicillin binding
DWB95_RS07815	COG4839	cell division protein FtsL
DWB95_RS07820	COG0275	rRNA processing
DWB95_RS07830	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DWB95_RS07840	COG1011	Hydrolase
DWB95_RS07870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB95_RS07885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWB95_RS07890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DWB95_RS07895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB95_RS07900	COG1053	succinate dehydrogenase
DWB95_RS07905	COG2009	succinate dehydrogenase
DWB95_RS07910	COG0322	excinuclease ABC activity
DWB95_RS07915	COG3118	belongs to the thioredoxin family
DWB95_RS07920	COG1193	negative regulation of DNA recombination
DWB95_RS07925	COG1796	DNA polymerase
DWB95_RS07925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWB95_RS07935	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWB95_RS07940	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB95_RS07945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB95_RS07945	COG0072	phenylalanine-tRNA ligase activity
DWB95_RS07950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB95_RS07955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB95_RS07965	COG4509	Sortase family
DWB95_RS08000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB95_RS08020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB95_RS08025	COG0742	ribosomal rna small subunit methyltransferase
DWB95_RS08040	COG0584	glycerophosphoryl diester phosphodiesterase
DWB95_RS08050	COG0107	imidazoleglycerol-phosphate synthase activity
DWB95_RS08055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWB95_RS08060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWB95_RS08065	COG0131	Imidazoleglycerol-phosphate dehydratase
DWB95_RS08070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB95_RS08080	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DWB95_RS08085	COG3679	Belongs to the UPF0342 family
DWB95_RS08100	COG0109	protoheme IX farnesyltransferase activity
DWB95_RS08105	COG1612	heme a metabolic process
DWB95_RS08115	COG0772	Belongs to the SEDS family
DWB95_RS08120	COG4838	Belongs to the UPF0358 family
DWB95_RS08125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB95_RS08130	COG4896	Protein conserved in bacteria
DWB95_RS08135	COG1217	gtp-binding protein TYPA
DWB95_RS08145	COG0483	inositol monophosphate 1-phosphatase activity
DWB95_RS08150	COG4493	Belongs to the UPF0637 family
DWB95_RS08175	COG1177	transmembrane transport
DWB95_RS08180	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWB95_RS08195	COG4476	Belongs to the UPF0223 family
DWB95_RS08205	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB95_RS08210	COG0022	dehydrogenase e1 component
DWB95_RS08225	COG0242	peptide deformylase activity
DWB95_RS08230	COG5503	Protein of unknown function (DUF1447)
DWB95_RS08240	COG0569	domain protein
DWB95_RS08245	COG1294	oxidase, subunit
DWB95_RS08250	COG1271	oxidase subunit
DWB95_RS08260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB95_RS08265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB95_RS08275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB95_RS08295	COG1122	ATPase activity
DWB95_RS08300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DWB95_RS08310	COG0151	Belongs to the GarS family
DWB95_RS08315	COG0138	bifunctional purine biosynthesis protein purh
DWB95_RS08325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB95_RS08335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB95_RS08340	COG0047	phosphoribosylformylglycinamidine synthase activity
DWB95_RS08345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB95_RS08355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB95_RS08360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB95_RS08365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB95_RS08365	COG1017	nitric oxide dioxygenase activity
DWB95_RS08375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB95_RS08390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB95_RS08405	COG1316	TRANSCRIPTIONal
DWB95_RS08430	COG3594	Acyltransferase
DWB95_RS08435	COG0436	Aminotransferase
DWB95_RS08440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWB95_RS08450	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DWB95_RS08455	COG1169	isochorismate synthase
DWB95_RS08460	COG1575	Belongs to the MenA family. Type 1 subfamily
DWB95_RS08470	COG2314	TM2 domain
DWB95_RS08475	COG2808	Putative FMN-binding domain
DWB95_RS08480	COG0456	acetyltransferase
DWB95_RS08485	COG1846	Transcriptional regulator
DWB95_RS08520	COG4873	Protein conserved in bacteria
DWB95_RS08530	COG0737	Belongs to the 5'-nucleotidase family
DWB95_RS08535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB95_RS08540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB95_RS08540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB95_RS08545	COG0861	Integral membrane protein TerC family
DWB95_RS08550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DWB95_RS08560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB95_RS08565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB95_RS08570	COG2814	Major facilitator Superfamily
DWB95_RS08575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB95_RS08580	COG2382	esterase
DWB95_RS08585	COG1115	amino acid carrier protein
DWB95_RS08590	COG0628	permease
DWB95_RS08600	COG0475	glutathione-regulated potassium exporter activity
DWB95_RS08600	COG0569	domain protein
DWB95_RS08605	COG2239	Acts as a magnesium transporter
DWB95_RS08610	COG0564	pseudouridine synthase activity
DWB95_RS08615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWB95_RS08620	COG2357	RelA SpoT domain protein
DWB95_RS08635	COG2346	COG2346, Truncated hemoglobins
DWB95_RS08645	COG1164	Oligoendopeptidase f
DWB95_RS08655	COG4862	establishment of competence for transformation
DWB95_RS08660	COG1393	Belongs to the ArsC family
DWB95_RS08665	COG0180	Tryptophanyl-tRNA synthetase
DWB95_RS08675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB95_RS08680	COG0601	transmembrane transport
DWB95_RS08685	COG4608	Belongs to the ABC transporter superfamily
DWB95_RS08690	COG0444	Belongs to the ABC transporter superfamily
DWB95_RS08710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB95_RS08720	COG1881	PFAM PEBP family protein
DWB95_RS08725	COG0542	response to heat
DWB95_RS08740	COG0561	phosphatase activity
DWB95_RS08760	COG1074	ATP-dependent DNA helicase activity
DWB95_RS08780	COG0398	Pfam SNARE associated Golgi protein
DWB95_RS08790	COG0137	argininosuccinate synthase activity
DWB95_RS08795	COG0165	Argininosuccinate lyase
DWB95_RS08800	COG0584	glycerophosphoryl diester phosphodiesterase
DWB95_RS08805	COG0584	glycerophosphoryl diester phosphodiesterase
DWB95_RS08825	COG1902	pentaerythritol trinitrate reductase activity
DWB95_RS08830	COG1098	S1 RNA binding domain
DWB95_RS08845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB95_RS08845	COG2111	Na H antiporter
DWB95_RS08850	COG2111	Na H antiporter
DWB95_RS08860	COG0651	ATP synthesis coupled electron transport
DWB95_RS08870	COG2212	antiporter activity
DWB95_RS08890	COG2050	protein possibly involved in aromatic compounds catabolism
DWB95_RS08895	COG2056	Na+-H+ antiporter family
DWB95_RS08900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB95_RS08910	COG0316	Belongs to the HesB IscA family
DWB95_RS08915	COG4844	belongs to the
DWB95_RS08920	COG1252	NADH dehydrogenase
DWB95_RS08925	COG4837	Protein of unknown function (DUF1462)
DWB95_RS08930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB95_RS08935	COG0583	DNA-binding transcription factor activity
DWB95_RS08945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DWB95_RS08955	COG1696	Membrane protein involved in D-alanine export
DWB95_RS08960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB95_RS08980	COG2445	Protein of unknown function DUF86
DWB95_RS08990	COG4470	Protein conserved in bacteria
DWB95_RS08995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWB95_RS09000	COG0737	Belongs to the 5'-nucleotidase family
DWB95_RS09005	COG0730	response to heat
DWB95_RS09010	COG1801	Protein of unknown function DUF72
DWB95_RS09015	COG2070	2-Nitropropane dioxygenase
DWB95_RS09020	COG1253	flavin adenine dinucleotide binding
DWB95_RS09025	COG0719	Fe-S assembly protein
DWB95_RS09030	COG0822	iron-sulfur transferase activity
DWB95_RS09035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB95_RS09040	COG0719	Fe-S assembly protein
DWB95_RS09045	COG0396	ATPase activity
DWB95_RS09055	COG3237	CsbD-like
DWB95_RS09060	COG1464	Belongs to the NlpA lipoprotein family
DWB95_RS09065	COG2011	ABC-type metal ion transport system permease component
DWB95_RS09070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB95_RS09080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB95_RS09085	COG0509	glycine decarboxylation via glycine cleavage system
DWB95_RS09090	COG1393	Belongs to the ArsC family
DWB95_RS09095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB95_RS09105	COG0710	3-dehydroquinate dehydratase activity
DWB95_RS09110	COG1764	response to oxidative stress
DWB95_RS09120	COG0406	alpha-ribazole phosphatase activity
DWB95_RS09155	COG4195	phage-related replication protein
DWB95_RS09180	COG1278	Cold shock
DWB95_RS09195	COG3433	isochorismatase activity
DWB95_RS09195	COG1535	isochorismatase
DWB95_RS09230	COG0346	lactoylglutathione lyase activity
DWB95_RS09280	COG0557	exoribonuclease II activity
DWB95_RS09285	COG1647	Serine aminopeptidase, S33
DWB95_RS09290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB95_RS09300	COG0148	phosphopyruvate hydratase activity
DWB95_RS09305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DWB95_RS09310	COG0149	triose-phosphate isomerase activity
DWB95_RS09315	COG0126	phosphoglycerate kinase activity
DWB95_RS09350	COG0740	serine-type endopeptidase activity
DWB95_RS09365	COG1388	LysM domain
DWB95_RS09365	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB95_RS09440	COG0740	serine-type endopeptidase activity
DWB95_RS09505	COG1525	nuclease
DWB95_RS09575	COG0629	single-stranded DNA binding
DWB95_RS09625	COG1396	sequence-specific DNA binding
DWB95_RS09665	COG1481	regulation of sporulation
DWB95_RS09670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB95_RS09675	COG1660	Displays ATPase and GTPase activities
DWB95_RS09680	COG0492	ferredoxin-NADP+ reductase activity
DWB95_RS09690	COG0110	maltose O-acetyltransferase activity
DWB95_RS09695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB95_RS09705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB95_RS09710	COG0556	nucleotide-excision repair
DWB95_RS09725	COG1388	LysM domain
DWB95_RS09725	COG3942	CHAP domain
DWB95_RS09735	COG0653	protein targeting
DWB95_RS09740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB95_RS09745	COG1040	competence protein
DWB95_RS09750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DWB95_RS09760	COG1739	Uncharacterized protein family UPF0029
DWB95_RS09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB95_RS09785	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB95_RS09790	COG1929	Belongs to the glycerate kinase type-1 family
DWB95_RS09810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB95_RS09825	COG4604	ABC transporter, ATP-binding protein
DWB95_RS09830	COG4605	iron ion homeostasis
DWB95_RS09835	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS09840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB95_RS09845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB95_RS09850	COG1780	Probably involved in ribonucleotide reductase function
DWB95_RS09865	COG3104	oligopeptide transport
DWB95_RS09870	COG1597	lipid kinase activity
DWB95_RS09880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB95_RS09885	COG1174	glycine betaine transport
DWB95_RS09890	COG0517	IMP dehydrogenase activity
DWB95_RS09890	COG1125	glycine betaine transport
DWB95_RS09895	COG0514	ATP-dependent DNA helicase (RecQ)
DWB95_RS09900	COG0488	(ABC) transporter
DWB95_RS09910	COG1368	sulfuric ester hydrolase activity
DWB95_RS09940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB95_RS09940	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB95_RS09945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DWB95_RS09950	COG0720	synthase
DWB95_RS09965	COG0463	Glycosyl transferase, family 2
DWB95_RS09970	COG0656	L-ascorbic acid biosynthetic process
DWB95_RS09975	COG1253	flavin adenine dinucleotide binding
DWB95_RS09980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB95_RS09985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB95_RS09985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB95_RS09985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB95_RS09990	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB95_RS09995	COG1349	DNA-binding transcription factor activity
DWB95_RS10000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB95_RS10025	COG0415	Belongs to the DNA photolyase family
DWB95_RS10030	COG0471	metal ion transport
DWB95_RS10035	COG0039	L-malate dehydrogenase activity
DWB95_RS10045	COG4989	oxidoreductase activity
DWB95_RS10050	COG0523	cobalamin synthesis protein
DWB95_RS10060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWB95_RS10065	COG4988	ABC transporter
DWB95_RS10070	COG1968	undecaprenyl-diphosphatase activity
DWB95_RS10085	COG1611	Belongs to the LOG family
DWB95_RS10090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB95_RS10115	COG2839	Protein conserved in bacteria
DWB95_RS10120	COG2814	Major facilitator Superfamily
DWB95_RS10125	COG0583	DNA-binding transcription factor activity
DWB95_RS10140	COG0217	transcriptional regulatory protein
DWB95_RS10150	COG2169	Transcriptional regulator
DWB95_RS10160	COG1388	LysM domain
DWB95_RS10160	COG3942	CHAP domain
DWB95_RS10165	COG0306	phosphate transporter
DWB95_RS10170	COG1392	Phosphate transport regulator
DWB95_RS10180	COG0577	efflux transmembrane transporter activity
DWB95_RS10185	COG1136	(ABC) transporter
DWB95_RS10190	COG2205	protein histidine kinase activity
DWB95_RS10195	COG0745	RESPONSE REGULATOR receiver
DWB95_RS10200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB95_RS10210	COG0657	acetylesterase activity
DWB95_RS10215	COG3949	Membrane
DWB95_RS10225	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DWB95_RS10230	COG1461	Dihydroxyacetone kinase
DWB95_RS10235	COG2376	Dihydroxyacetone kinase
DWB95_RS10240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS10250	COG1120	ATPase activity
DWB95_RS10255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB95_RS10260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB95_RS10270	COG1132	(ABC) transporter
DWB95_RS10275	COG1686	Belongs to the peptidase S11 family
DWB95_RS10280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWB95_RS10290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB95_RS10295	COG1682	transport, permease protein
DWB95_RS10300	COG1134	teichoic acid transport
DWB95_RS10305	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DWB95_RS10320	COG1121	(ABC) transporter
DWB95_RS10325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB95_RS10330	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB95_RS10340	COG1320	monovalent cation:proton antiporter activity
DWB95_RS10350	COG1863	multisubunit Na H antiporter MnhE subunit
DWB95_RS10355	COG0651	ATP synthesis coupled electron transport
DWB95_RS10360	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB95_RS10365	COG2111	Na H antiporter
DWB95_RS10370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB95_RS10370	COG2111	Na H antiporter
DWB95_RS10405	COG2267	carboxylic ester hydrolase activity
DWB95_RS10420	COG2267	carboxylic ester hydrolase activity
DWB95_RS10425	COG0546	phosphoglycolate phosphatase activity
DWB95_RS10430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB95_RS10435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB95_RS10440	COG0534	Mate efflux family protein
DWB95_RS10455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB95_RS10460	COG0018	arginyl-trna synthetase
DWB95_RS10480	COG3875	lactate racemase activity
DWB95_RS10485	COG1606	tRNA processing
DWB95_RS10490	COG1691	(AIR) carboxylase
DWB95_RS10495	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DWB95_RS10505	COG1078	dGTPase activity
DWB95_RS10510	COG0519	Catalyzes the synthesis of GMP from XMP
DWB95_RS10515	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWB95_RS10520	COG0667	Aldo Keto reductase
DWB95_RS10535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB95_RS10540	COG4844	belongs to the
DWB95_RS10555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWB95_RS10560	COG0095	Lipoate-protein ligase
DWB95_RS10565	COG0280	phosphate acetyltransferase
DWB95_RS10570	COG3253	May function as heme-dependent peroxidase
DWB95_RS10575	COG2966	Psort location CytoplasmicMembrane, score
DWB95_RS10590	COG2363	Small membrane protein
DWB95_RS10605	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DWB95_RS10615	COG0477	Major facilitator Superfamily
DWB95_RS10630	COG0183	Belongs to the thiolase family
DWB95_RS10635	COG0318	PFAM AMP-dependent synthetase and ligase
DWB95_RS10650	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB95_RS10655	COG0363	glucosamine-6-phosphate deaminase activity
DWB95_RS10665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB95_RS10670	COG1469	GTP cyclohydrolase I activity
DWB95_RS10675	COG2271	Major facilitator Superfamily
DWB95_RS10710	COG0431	NADPH-dependent FMN reductase
DWB95_RS10715	COG0561	phosphatase activity
DWB95_RS10725	COG1428	Deoxynucleoside kinase
DWB95_RS10730	COG1428	Deoxynucleoside kinase
DWB95_RS10735	COG0546	phosphoglycolate phosphatase activity
DWB95_RS10740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB95_RS10760	COG1063	alcohol dehydrogenase
DWB95_RS10765	COG2814	Major facilitator Superfamily
DWB95_RS10770	COG1349	DNA-binding transcription factor activity
DWB95_RS10790	COG1473	amidohydrolase
DWB95_RS10795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB95_RS10800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB95_RS10805	COG0049	tRNA binding
DWB95_RS10810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB95_RS10820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB95_RS10825	COG0085	RNA polymerase activity
DWB95_RS10830	COG2813	Specifically methylates the guanine in position
DWB95_RS10840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB95_RS10845	COG0081	regulation of translation
DWB95_RS10850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB95_RS10855	COG0250	Participates in transcription elongation, termination and antitermination
DWB95_RS10865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB95_RS10875	COG3688	RNA-binding protein containing a PIN domain
DWB95_RS10885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DWB95_RS10890	COG0215	cysteine-tRNA ligase activity
DWB95_RS10900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWB95_RS10905	COG4956	integral membrane protein (PIN domain superfamily)
DWB95_RS10910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWB95_RS10915	COG0542	response to heat
DWB95_RS10920	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DWB95_RS10925	COG3880	PFAM UvrB UvrC protein
DWB95_RS10935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB95_RS10940	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWB95_RS10945	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB95_RS10950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB95_RS11035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB95_RS11040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB95_RS11045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWB95_RS11055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB95_RS11065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB95_RS11080	COG1098	S1 RNA binding domain
DWB95_RS11090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWB95_RS11095	COG3956	TIGRFAM MazG family protein
DWB95_RS11100	COG2244	polysaccharide biosynthetic process
DWB95_RS11105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB95_RS11110	COG0193	aminoacyl-tRNA hydrolase activity
DWB95_RS11115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWB95_RS11120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB95_RS11125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB95_RS11130	COG2088	sporulation resulting in formation of a cellular spore
DWB95_RS11135	COG0251	oxidation-reduction process
DWB95_RS11140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB95_RS11145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB95_RS11150	COG4466	Protein conserved in bacteria
DWB95_RS11155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB95_RS11160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB95_RS11165	COG0084	hydrolase, TatD family'
DWB95_RS11170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB95_RS11170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB95_RS11175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWB95_RS11180	COG2827	Endonuclease containing a URI domain
DWB95_RS11185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB95_RS11190	COG4467	Involved in initiation control of chromosome replication
DWB95_RS11195	COG1774	PSP1 C-terminal conserved region
DWB95_RS11200	COG0470	DNA polymerase III
DWB95_RS11205	COG3870	Protein conserved in bacteria
DWB95_RS11215	COG1982	Orn Lys Arg decarboxylase major
DWB95_RS11220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB95_RS11240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB95_RS11250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DWB95_RS11265	COG2188	Transcriptional regulator
DWB95_RS11270	COG0366	Alpha amylase catalytic
DWB95_RS11275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB95_RS11275	COG1263	PTS System
DWB95_RS11285	COG0493	'glutamate synthase
DWB95_RS11290	COG0067	glutamate synthase
DWB95_RS11290	COG0070	glutamate synthase
DWB95_RS11290	COG0069	glutamate synthase activity
DWB95_RS11295	COG0583	DNA-binding transcription factor activity
DWB95_RS11325	COG0438	transferase activity, transferring glycosyl groups
DWB95_RS11340	COG2011	ABC-type metal ion transport system permease component
DWB95_RS11345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB95_RS11350	COG1278	Cold shock
DWB95_RS11355	COG3759	membrane
DWB95_RS11375	COG0626	cystathionine gamma-synthase activity
DWB95_RS11380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB95_RS11395	COG1279	arginine transmembrane transporter activity
DWB95_RS11400	COG0733	neurotransmitter:sodium symporter activity
DWB95_RS11425	COG5609	conserved protein (DUF2294)
DWB95_RS11430	COG3002	Belongs to the UPF0753 family
DWB95_RS11435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB95_RS11445	COG0523	cobalamin synthesis protein
DWB95_RS11450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB95_RS11450	COG0519	Catalyzes the synthesis of GMP from XMP
DWB95_RS11455	COG0517	IMP dehydrogenase activity
DWB95_RS11455	COG0516	GMP reductase activity
DWB95_RS11460	COG2233	PERMEase
DWB95_RS11465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB95_RS11480	COG5183	chlorophyll binding
DWB95_RS11490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB95_RS11495	COG1063	alcohol dehydrogenase
DWB95_RS11505	COG1823	symporter activity
DWB95_RS11515	COG0450	alkyl hydroperoxide reductase
DWB95_RS11520	COG3634	alkyl hydroperoxide reductase activity
DWB95_RS11545	COG1280	lysine exporter protein (LysE YggA)
DWB95_RS11565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB95_RS11575	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB95_RS11590	COG0012	GTP binding
DWB95_RS11595	COG4481	Protein conserved in bacteria
DWB95_RS11600	COG0668	transmembrane transport
DWB95_RS11605	COG1475	DNA binding
DWB95_RS11615	COG0626	cystathionine gamma-synthase activity
DWB95_RS11620	COG0626	cystathionine gamma-synthase activity
DWB95_RS11625	COG0646	methionine synthase
DWB95_RS11625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB95_RS11630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DWB95_RS11660	COG3942	CHAP domain
DWB95_RS11690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB95_RS11710	COG2814	Major facilitator Superfamily
DWB95_RS11740	COG0183	Belongs to the thiolase family
DWB95_RS11745	COG3250	beta-galactosidase activity
DWB95_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
DWB95_RS11755	COG1312	Catalyzes the dehydration of D-mannonate
DWB95_RS11760	COG1904	glucuronate isomerase
DWB95_RS11765	COG2211	Major facilitator Superfamily
DWB95_RS11775	COG0800	Aldolase
DWB95_RS11780	COG2207	Transcriptional regulator
DWB95_RS11805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB95_RS11815	COG1136	(ABC) transporter
DWB95_RS11820	COG0577	efflux transmembrane transporter activity
DWB95_RS11845	COG0300	oxidoreductase activity
DWB95_RS11860	COG0577	efflux transmembrane transporter activity
DWB95_RS11865	COG1136	(ABC) transporter
DWB95_RS11895	COG1475	DNA binding
DWB95_RS11900	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB95_RS11905	COG0445	tRNA wobble uridine modification
DWB95_RS11910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWB95_RS11915	COG0594	ribonuclease P activity
DWB95_RS11945	COG3871	stress protein (general stress protein 26)
DWB95_RS11975	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DWB95_RS12020	COG1002	Type II restriction enzyme, methylase subunits
DWB95_RS12040	COG1063	alcohol dehydrogenase
DWB95_RS12045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB95_RS12045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB95_RS12050	COG4716	Myosin-crossreactive antigen
DWB95_RS12055	COG0579	oxidoreductase
DWB95_RS12070	COG1288	antiporter activity
DWB95_RS12075	COG0693	protein deglycase activity
DWB95_RS12080	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB95_RS12085	COG1733	regulation of RNA biosynthetic process
DWB95_RS12100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB95_RS12105	COG1846	Transcriptional regulator
DWB95_RS12120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB95_RS12130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB95_RS12140	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DWB95_RS12165	COG1609	Transcriptional regulator
DWB95_RS12170	COG0366	Alpha amylase catalytic
DWB95_RS12175	COG0789	Transcriptional regulator
DWB95_RS12185	COG0702	epimerase
DWB95_RS12190	COG2130	NADP-dependent
DWB95_RS12220	COG2814	Major facilitator Superfamily
DWB95_RS12255	COG1192	Involved in chromosome partitioning
DWB95_RS12340	COG1192	Involved in chromosome partitioning
DWB95_RS12375	COG2814	Major facilitator Superfamily
DWB95_RS12405	COG2130	NADP-dependent
DWB95_RS12410	COG0702	epimerase
DWB95_RS12420	COG0789	Transcriptional regulator
DWB95_RS12435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB95_RS12440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB95_RS12445	COG0730	response to heat
DWB95_RS12450	COG1937	Protein conserved in bacteria
DWB95_RS12455	COG2210	Belongs to the sulfur carrier protein TusA family
DWB95_RS12460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB95_RS12470	COG1253	flavin adenine dinucleotide binding
DWB95_RS12480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB95_RS12500	COG1388	LysM domain
DWB95_RS12505	COG2132	Multicopper oxidase